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Conserved domains on  [gi|48255953|ref|NP_068768|]
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plasma membrane calcium-transporting ATPase 3 isoform 3a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ATPase-IIB_Ca super family cl36924
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
27-1061 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


The actual alignment was detected with superfamily member TIGR01517:

Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1346.74  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953     27 FGCTLAELRTLMELRGAEALQK---IEEAYGDVSGLCRRLKTSPTEGLADNTNDLEKRRQIYGQNFIPPKQPKTFLQLVW 103
Cdd:TIGR01517   13 NFTDGFDVGVSILTDLTDIFKKampLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELPEKPPKSFLQIVW 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    104 EALQDVTLIILEVAAIVSLGLSFYAP-PGEeseacgnvsggaeDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQF 182
Cdd:TIGR01517   93 AALSDQTLILLSVAAVVSLVLGLYVPsVGE-------------DKADTETGWIEGVAILVSVILVVLVTAVNDYKKELQF 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    183 RGLQsRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLKIDESSLTGESDHVRKSADKDPMLL 262
Cdd:TIGR01517  160 RQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIKKGPVQDPFLL 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    263 SGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGaggeeeekkdkkgkqqdgamessqtkakkqdgavamemqplksaEGGEm 342
Cdd:TIGR01517  239 SGTVVNEGSGRMLVTAVGVNSFGGKLMMELR--------------------------------------------QAGE- 273
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    343 eerekkkanapkkEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFVVEGRTwlaECTPVYVQYFVKFFIIGV 422
Cdd:TIGR01517  274 -------------EETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEEDAQTFLDHFIIAV 337
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    423 TVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIPAps 502
Cdd:TIGR01517  338 TIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQRFNVRDE-- 415
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    503 aLTPKILDLLVHAISINSAYTTKILPPEKE-GALPRQVGNKTECALLGFVLDLKRDFQPVREQIPEDKLYKVYTFNSVRK 581
Cdd:TIGR01517  416 -IVLRNLPAAVRNILVEGISLNSSSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKIYPFNSERK 494
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    582 SMSTVIRMPDGGFRLFSKGASEILLKKCTNILNSNGELRGFRPrDRDDMVRKIIEPMACDGLRTICIAYRDFSAGQEPDW 661
Cdd:TIGR01517  495 FMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISE-DDKDRCADVIEPLASDALRTICLAYRDFAPEEFPRK 573
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    662 DNENevvGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEdfLCLEGKEFNRRIR 741
Cdd:TIGR01517  574 DYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEGKEFRSLVY 648
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    742 NEkgeieqerLDKVWPKLRVLARSSPTDKHTLVKGIIDsttgeQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKE 821
Cdd:TIGR01517  649 EE--------MDPILPKLRVLARSSPLDKQLLVLMLKD-----MGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVAKE 715
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    822 ASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQMLWVNLIMDTFASLAL 899
Cdd:TIGR01517  716 ASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIMDTLAALAL 795
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    900 ATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVYQLAIIFTLLFVGELFFDIDSGRNAPlHSPPSEHYTIIFNTFVMM 979
Cdd:TIGR01517  796 ATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTIVFNTFVLL 874
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    980 QLFNEINARKIHGERNVFDGIFSNPIFCTIVLGTFGIQIVIVQFGGKPFSCSPLSTEQWLWCLFVGVGELVWGQVIATIP 1059
Cdd:TIGR01517  875 QLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIFGVLLRLIP 954

                   ..
gi 48255953   1060 TS 1061
Cdd:TIGR01517  955 VE 956
ATP_Ca_trans_C super family cl13811
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1100-1145 1.19e-08

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


The actual alignment was detected with superfamily member pfam12424:

Pssm-ID: 463575  Cd Length: 47  Bit Score: 52.02  E-value: 1.19e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 48255953   1100 GQILWFRGLNRIQTQMEVVSTFkRSGSVQGAvrRRSSVLSQLHDVT 1145
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAF-QSSLREGI--QKPYLRNSIHSFM 43
 
Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
27-1061 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1346.74  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953     27 FGCTLAELRTLMELRGAEALQK---IEEAYGDVSGLCRRLKTSPTEGLADNTNDLEKRRQIYGQNFIPPKQPKTFLQLVW 103
Cdd:TIGR01517   13 NFTDGFDVGVSILTDLTDIFKKampLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELPEKPPKSFLQIVW 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    104 EALQDVTLIILEVAAIVSLGLSFYAP-PGEeseacgnvsggaeDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQF 182
Cdd:TIGR01517   93 AALSDQTLILLSVAAVVSLVLGLYVPsVGE-------------DKADTETGWIEGVAILVSVILVVLVTAVNDYKKELQF 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    183 RGLQsRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLKIDESSLTGESDHVRKSADKDPMLL 262
Cdd:TIGR01517  160 RQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIKKGPVQDPFLL 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    263 SGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGaggeeeekkdkkgkqqdgamessqtkakkqdgavamemqplksaEGGEm 342
Cdd:TIGR01517  239 SGTVVNEGSGRMLVTAVGVNSFGGKLMMELR--------------------------------------------QAGE- 273
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    343 eerekkkanapkkEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFVVEGRTwlaECTPVYVQYFVKFFIIGV 422
Cdd:TIGR01517  274 -------------EETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEEDAQTFLDHFIIAV 337
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    423 TVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIPAps 502
Cdd:TIGR01517  338 TIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQRFNVRDE-- 415
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    503 aLTPKILDLLVHAISINSAYTTKILPPEKE-GALPRQVGNKTECALLGFVLDLKRDFQPVREQIPEDKLYKVYTFNSVRK 581
Cdd:TIGR01517  416 -IVLRNLPAAVRNILVEGISLNSSSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKIYPFNSERK 494
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    582 SMSTVIRMPDGGFRLFSKGASEILLKKCTNILNSNGELRGFRPrDRDDMVRKIIEPMACDGLRTICIAYRDFSAGQEPDW 661
Cdd:TIGR01517  495 FMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISE-DDKDRCADVIEPLASDALRTICLAYRDFAPEEFPRK 573
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    662 DNENevvGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEdfLCLEGKEFNRRIR 741
Cdd:TIGR01517  574 DYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEGKEFRSLVY 648
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    742 NEkgeieqerLDKVWPKLRVLARSSPTDKHTLVKGIIDsttgeQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKE 821
Cdd:TIGR01517  649 EE--------MDPILPKLRVLARSSPLDKQLLVLMLKD-----MGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVAKE 715
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    822 ASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQMLWVNLIMDTFASLAL 899
Cdd:TIGR01517  716 ASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIMDTLAALAL 795
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    900 ATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVYQLAIIFTLLFVGELFFDIDSGRNAPlHSPPSEHYTIIFNTFVMM 979
Cdd:TIGR01517  796 ATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTIVFNTFVLL 874
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    980 QLFNEINARKIHGERNVFDGIFSNPIFCTIVLGTFGIQIVIVQFGGKPFSCSPLSTEQWLWCLFVGVGELVWGQVIATIP 1059
Cdd:TIGR01517  875 QLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIFGVLLRLIP 954

                   ..
gi 48255953   1060 TS 1061
Cdd:TIGR01517  955 VE 956
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
78-925 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1331.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   78 LEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYAPPGEeseacgnvsggaedeGEAEAGWIEG 157
Cdd:cd02081    1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGE---------------GEGKTGWIEG 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  158 AAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEqEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDL 237
Cdd:cd02081   66 VAILVAVILVVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDL 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  238 KIDESSLTGESDHVRKSAD---KDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGgeeeekkdkkgkqqdgame 314
Cdd:cd02081  145 KIDESSLTGESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAE------------------- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  315 ssqtkakkqdgavamemqplksaeggemeerekkkanapKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIET 394
Cdd:cd02081  206 ---------------------------------------NEEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLIIRFIIDG 246
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  395 FVVEGRtwlaECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 474
Cdd:cd02081  247 FVNDGK----SFSAEDLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 322
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  475 TGTLTTNRMTVVQSYlgdthykeipapsaltpkildllvhaisinsayttkilppekegalprqVGNKTECALLGFVLDL 554
Cdd:cd02081  323 TGTLTQNRMTVVQGY-------------------------------------------------IGNKTECALLGFVLEL 353
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  555 KRDFQpVREQIPEDKLYKVYTFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNILNSNGElRGFRPRDRDDMVRKI 634
Cdd:cd02081  354 GGDYR-YREKRPEEKVLKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLKKCSYILNSDGE-VVFLTSEKKEEIKRV 431
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  635 IEPMACDGLRTICIAYRDFSAGQEP----DWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNIN 710
Cdd:cd02081  432 IEPMASDSLRTIGLAYRDFSPDEEPtaerDWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNIN 511
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  711 TARAIAAKCGIIQPGEDFLCLEGKEFNRRIRNEKGEIEQERLDKVWPKLRVLARSSPTDKHTLVKGIIDSttgeqRQVVA 790
Cdd:cd02081  512 TARAIARECGILTEGEDGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-----GEVVA 586
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  791 VTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 870
Cdd:cd02081  587 VTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAFIG 666
                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 48255953  871 ACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLISRTM 925
Cdd:cd02081  667 AVVTKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISRTM 721
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
55-1055 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 706.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   55 DVSGLCRRLKTSPtEGLadNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLsfyappgees 134
Cdd:COG0474   12 SAEEVLAELGTSE-EGL--SSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALL---------- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  135 eacgnvsggaedeGEaeagWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQeqKFTVIRNGQLLQVPVAALVVG 214
Cdd:COG0474   79 -------------GD----WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAP--TARVLRDGKWVEIPAEELVPG 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  215 DIAQVKYGDLLPADGVLIQANDLKIDESSLTGESDHVRKSA----------DKDPMLLSGTHVMEGSGRMVVTAVGVNSQ 284
Cdd:COG0474  140 DIVLLEAGDRVPADLRLLEAKDLQVDESALTGESVPVEKSAdplpedaplgDRGNMVFMGTLVTSGRGTAVVVATGMNTE 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  285 TGIIFTLLGAGgeeeekkdkkgkqqdgamessqtkakkqdgavamemqplksaeggemeerekkkanapKKEKSVLQGKL 364
Cdd:COG0474  220 FGKIAKLLQEA----------------------------------------------------------EEEKTPLQKQL 241
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  365 TKLAVQIGKAGLVMSAITVIILVLYfvietfvveGRTWLAectpvyvqyfvkFFIIGVTVLVVAVPEGLPLAVTISLAYS 444
Cdd:COG0474  242 DRLGKLLAIIALVLAALVFLIGLLR---------GGPLLE------------ALLFAVALAVAAIPEGLPAVVTITLALG 300
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  445 VKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYkeipAPSALTPKILDLLVHAISINSAYTt 524
Cdd:COG0474  301 AQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTY----EVTGEFDPALEELLRAAALCSDAQ- 375
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  525 kiLPPEKEgalprqVGNKTECALLGFVLDLKRDFQPVREQIPedkLYKVYTFNSVRKSMSTVIRMPDGGFRLFSKGASEI 604
Cdd:COG0474  376 --LEEETG------LGDPTEGALLVAAAKAGLDVEELRKEYP---RVDEIPFDSERKRMSTVHEDPDGKRLLIVKGAPEV 444
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  605 LLKKCTNILnSNGELRGFRPRDRDDmVRKIIEPMACDGLRTICIAYRDFSAGQEPDwdnENEVVGDLTCIAVVGIEDPVR 684
Cdd:COG0474  445 VLALCTRVL-TGGGVVPLTEEDRAE-ILEAVEELAAQGLRVLAVAYKELPADPELD---SEDDESDLTFLGLVGMIDPPR 519
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  685 PEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEDflCLEGKEFNRrirnekgeIEQERLDKVWPKLRVLAR 764
Cdd:COG0474  520 PEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR--VLTGAELDA--------MSDEELAEAVEDVDVFAR 589
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  765 SSPTDKHTLVKGIidsttgeQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWG 842
Cdd:COG0474  590 VSPEHKLRIVKAL-------QANghVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEG 662
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  843 RNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLIS 922
Cdd:COG0474  663 RRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILS 742
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  923 RTMMKNILGHAVYQLAIIFTLLFVGelffdIDSGRNAPLHSppsehyTIIFNTFVMMQLFNEINARKIHgeRNVFD-GIF 1001
Cdd:COG0474  743 RFLLLRILLLGLLIAIFTLLTFALA-----LARGASLALAR------TMAFTTLVLSQLFNVFNCRSER--RSFFKsGLF 809
                        970       980       990      1000      1010
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 48255953 1002 SNPIFCTIVLGTFGIQIVIVQ--FGGKPFSCSPLSTEQWLWCLFVGVGELVWGQVI 1055
Cdd:COG0474  810 PNRPLLLAVLLSLLLQLLLIYvpPLQALFGTVPLPLSDWLLILGLALLYLLLVELV 865
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
55-867 1.55e-51

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 196.83  E-value: 1.55e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    55 DVSGLCRRLKTSPtEGLadNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSlglsfYAppgees 134
Cdd:PRK10517   53 PEEELWKTFDTHP-EGL--NEAEVESAREQHGENELPAQKPLPWWVHLWVCYRNPFNILLTILGAIS-----YA------ 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   135 eacgnvsggAEDEGeaeagwiegAAILLSVIcVVLVTAFNDWSKEKQFRG---LQSRIEQeqKFTVIRNG------QLLQ 205
Cdd:PRK10517  119 ---------TEDLF---------AAGVIALM-VAISTLLNFIQEARSTKAadaLKAMVSN--TATVLRVIndkgenGWLE 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   206 VPVAALVVGDIAQVKYGDLLPADGVLIQANDLKIDESSLTGESDHVRKSA-----------DKDPMLLSGTHVMEGSGRM 274
Cdd:PRK10517  178 IPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKFAttrqpehsnplECDTLCFMGTNVVSGTAQA 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   275 VVTAVGVNSQTGiifTLLGaggeeeekkdkkgkqQDGAMESSQTKAKKQDGAVAMemqplksaeggemeerekkkanapk 354
Cdd:PRK10517  258 VVIATGANTWFG---QLAG---------------RVSEQDSEPNAFQQGISRVSW------------------------- 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   355 keksvlqgKLTKLAvqigkagLVMSAItviilVLYfvIETFVvEGRTWLAectpvyvqyfvkfFIIGVTVLVVAVPEGLP 434
Cdd:PRK10517  295 --------LLIRFM-------LVMAPV-----VLL--INGYT-KGDWWEA-------------ALFALSVAVGLTPEMLP 338
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   435 LAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQsylgdtHYKEIPAPSaltpkilDLLVH 514
Cdd:PRK10517  339 MIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKIVLEN------HTDISGKTS-------ERVLH 405
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   515 AISINSAYTTKIlppekEGALPRQVgnkTECALLGFVLDLKRDFQPVREqIPedklykvytFNSVRKSMSTVIRMPDGGF 594
Cdd:PRK10517  406 SAWLNSHYQTGL-----KNLLDTAV---LEGVDEESARSLASRWQKIDE-IP---------FDFERRRMSVVVAENTEHH 467
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   595 RLFSKGASEILLKKCTNILNsNGELRGFRPrDRDDMVRKIIEPMACDGLRTICIAYRDFSAGQEpDWDNENEvvGDLTCI 674
Cdd:PRK10517  468 QLICKGALEEILNVCSQVRH-NGEIVPLDD-IMLRRIKRVTDTLNRQGLRVVAVATKYLPAREG-DYQRADE--SDLILE 542
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   675 AVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNintaRAIAAKcgiiqpgedfLCLE-GKEFNRRIRNekGEIEQ---E 750
Cdd:PRK10517  543 GYIAFLDPPKETTAPALKALKASGVTVKILTGDS----ELVAAK----------VCHEvGLDAGEVLIG--SDIETlsdD 606
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   751 RLDKVWPKLRVLARSSPTDKHTLVKGIIDsttgeQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDD 830
Cdd:PRK10517  607 ELANLAERTTLFARLTPMHKERIVTLLKR-----EGHVVGFMGDGINDAPALRAADIGISVD-GAVDIAREAADIILLEK 680
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|..
gi 48255953   831 NFTSIVKAVMWGRNVYDSISKFLqfQLTV-----NVVAVIVA 867
Cdd:PRK10517  681 SLMVLEEGVIEGRRTFANMLKYI--KMTAssnfgNVFSVLVA 720
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
877-1055 7.21e-51

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 177.05  E-value: 7.21e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    877 SPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVYQLAIIFTLLFVGELFFDIDSG 956
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISES 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    957 RNAplhsppsehYTIIFNTFVMMQLFNEINARKIHGERNVFdGIFSNPIFCTIVLGTFGIQIVIVQ--FGGKPFSCSPLS 1034
Cdd:pfam00689   82 QNA---------QTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYvpPLQAVFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 48255953   1035 TEQWLWCLFVGVGELVWGQVI 1055
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
59-124 4.19e-11

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 59.90  E-value: 4.19e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 48255953      59 LCRRLKTSPTEGLadNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGL 124
Cdd:smart00831   12 VLERLQTDLEKGL--SSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1100-1145 1.19e-08

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 52.02  E-value: 1.19e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 48255953   1100 GQILWFRGLNRIQTQMEVVSTFkRSGSVQGAvrRRSSVLSQLHDVT 1145
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAF-QSSLREGI--QKPYLRNSIHSFM 43
 
Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
27-1061 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1346.74  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953     27 FGCTLAELRTLMELRGAEALQK---IEEAYGDVSGLCRRLKTSPTEGLADNTNDLEKRRQIYGQNFIPPKQPKTFLQLVW 103
Cdd:TIGR01517   13 NFTDGFDVGVSILTDLTDIFKKampLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELPEKPPKSFLQIVW 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    104 EALQDVTLIILEVAAIVSLGLSFYAP-PGEeseacgnvsggaeDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQF 182
Cdd:TIGR01517   93 AALSDQTLILLSVAAVVSLVLGLYVPsVGE-------------DKADTETGWIEGVAILVSVILVVLVTAVNDYKKELQF 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    183 RGLQsRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLKIDESSLTGESDHVRKSADKDPMLL 262
Cdd:TIGR01517  160 RQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIKKGPVQDPFLL 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    263 SGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGaggeeeekkdkkgkqqdgamessqtkakkqdgavamemqplksaEGGEm 342
Cdd:TIGR01517  239 SGTVVNEGSGRMLVTAVGVNSFGGKLMMELR--------------------------------------------QAGE- 273
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    343 eerekkkanapkkEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFVVEGRTwlaECTPVYVQYFVKFFIIGV 422
Cdd:TIGR01517  274 -------------EETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEEDAQTFLDHFIIAV 337
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    423 TVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIPAps 502
Cdd:TIGR01517  338 TIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQRFNVRDE-- 415
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    503 aLTPKILDLLVHAISINSAYTTKILPPEKE-GALPRQVGNKTECALLGFVLDLKRDFQPVREQIPEDKLYKVYTFNSVRK 581
Cdd:TIGR01517  416 -IVLRNLPAAVRNILVEGISLNSSSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKIYPFNSERK 494
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    582 SMSTVIRMPDGGFRLFSKGASEILLKKCTNILNSNGELRGFRPrDRDDMVRKIIEPMACDGLRTICIAYRDFSAGQEPDW 661
Cdd:TIGR01517  495 FMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISE-DDKDRCADVIEPLASDALRTICLAYRDFAPEEFPRK 573
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    662 DNENevvGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEdfLCLEGKEFNRRIR 741
Cdd:TIGR01517  574 DYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEGKEFRSLVY 648
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    742 NEkgeieqerLDKVWPKLRVLARSSPTDKHTLVKGIIDsttgeQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKE 821
Cdd:TIGR01517  649 EE--------MDPILPKLRVLARSSPLDKQLLVLMLKD-----MGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVAKE 715
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    822 ASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQMLWVNLIMDTFASLAL 899
Cdd:TIGR01517  716 ASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIMDTLAALAL 795
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    900 ATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVYQLAIIFTLLFVGELFFDIDSGRNAPlHSPPSEHYTIIFNTFVMM 979
Cdd:TIGR01517  796 ATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTIVFNTFVLL 874
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    980 QLFNEINARKIHGERNVFDGIFSNPIFCTIVLGTFGIQIVIVQFGGKPFSCSPLSTEQWLWCLFVGVGELVWGQVIATIP 1059
Cdd:TIGR01517  875 QLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIFGVLLRLIP 954

                   ..
gi 48255953   1060 TS 1061
Cdd:TIGR01517  955 VE 956
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
78-925 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1331.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   78 LEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYAPPGEeseacgnvsggaedeGEAEAGWIEG 157
Cdd:cd02081    1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGE---------------GEGKTGWIEG 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  158 AAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEqEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDL 237
Cdd:cd02081   66 VAILVAVILVVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDL 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  238 KIDESSLTGESDHVRKSAD---KDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGgeeeekkdkkgkqqdgame 314
Cdd:cd02081  145 KIDESSLTGESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAE------------------- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  315 ssqtkakkqdgavamemqplksaeggemeerekkkanapKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIET 394
Cdd:cd02081  206 ---------------------------------------NEEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLIIRFIIDG 246
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  395 FVVEGRtwlaECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 474
Cdd:cd02081  247 FVNDGK----SFSAEDLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 322
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  475 TGTLTTNRMTVVQSYlgdthykeipapsaltpkildllvhaisinsayttkilppekegalprqVGNKTECALLGFVLDL 554
Cdd:cd02081  323 TGTLTQNRMTVVQGY-------------------------------------------------IGNKTECALLGFVLEL 353
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  555 KRDFQpVREQIPEDKLYKVYTFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNILNSNGElRGFRPRDRDDMVRKI 634
Cdd:cd02081  354 GGDYR-YREKRPEEKVLKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLKKCSYILNSDGE-VVFLTSEKKEEIKRV 431
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  635 IEPMACDGLRTICIAYRDFSAGQEP----DWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNIN 710
Cdd:cd02081  432 IEPMASDSLRTIGLAYRDFSPDEEPtaerDWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNIN 511
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  711 TARAIAAKCGIIQPGEDFLCLEGKEFNRRIRNEKGEIEQERLDKVWPKLRVLARSSPTDKHTLVKGIIDSttgeqRQVVA 790
Cdd:cd02081  512 TARAIARECGILTEGEDGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-----GEVVA 586
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  791 VTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 870
Cdd:cd02081  587 VTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAFIG 666
                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 48255953  871 ACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLISRTM 925
Cdd:cd02081  667 AVVTKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISRTM 721
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
55-1055 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 706.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   55 DVSGLCRRLKTSPtEGLadNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLsfyappgees 134
Cdd:COG0474   12 SAEEVLAELGTSE-EGL--SSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALL---------- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  135 eacgnvsggaedeGEaeagWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQeqKFTVIRNGQLLQVPVAALVVG 214
Cdd:COG0474   79 -------------GD----WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAP--TARVLRDGKWVEIPAEELVPG 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  215 DIAQVKYGDLLPADGVLIQANDLKIDESSLTGESDHVRKSA----------DKDPMLLSGTHVMEGSGRMVVTAVGVNSQ 284
Cdd:COG0474  140 DIVLLEAGDRVPADLRLLEAKDLQVDESALTGESVPVEKSAdplpedaplgDRGNMVFMGTLVTSGRGTAVVVATGMNTE 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  285 TGIIFTLLGAGgeeeekkdkkgkqqdgamessqtkakkqdgavamemqplksaeggemeerekkkanapKKEKSVLQGKL 364
Cdd:COG0474  220 FGKIAKLLQEA----------------------------------------------------------EEEKTPLQKQL 241
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  365 TKLAVQIGKAGLVMSAITVIILVLYfvietfvveGRTWLAectpvyvqyfvkFFIIGVTVLVVAVPEGLPLAVTISLAYS 444
Cdd:COG0474  242 DRLGKLLAIIALVLAALVFLIGLLR---------GGPLLE------------ALLFAVALAVAAIPEGLPAVVTITLALG 300
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  445 VKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYkeipAPSALTPKILDLLVHAISINSAYTt 524
Cdd:COG0474  301 AQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTY----EVTGEFDPALEELLRAAALCSDAQ- 375
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  525 kiLPPEKEgalprqVGNKTECALLGFVLDLKRDFQPVREQIPedkLYKVYTFNSVRKSMSTVIRMPDGGFRLFSKGASEI 604
Cdd:COG0474  376 --LEEETG------LGDPTEGALLVAAAKAGLDVEELRKEYP---RVDEIPFDSERKRMSTVHEDPDGKRLLIVKGAPEV 444
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  605 LLKKCTNILnSNGELRGFRPRDRDDmVRKIIEPMACDGLRTICIAYRDFSAGQEPDwdnENEVVGDLTCIAVVGIEDPVR 684
Cdd:COG0474  445 VLALCTRVL-TGGGVVPLTEEDRAE-ILEAVEELAAQGLRVLAVAYKELPADPELD---SEDDESDLTFLGLVGMIDPPR 519
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  685 PEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEDflCLEGKEFNRrirnekgeIEQERLDKVWPKLRVLAR 764
Cdd:COG0474  520 PEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR--VLTGAELDA--------MSDEELAEAVEDVDVFAR 589
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  765 SSPTDKHTLVKGIidsttgeQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWG 842
Cdd:COG0474  590 VSPEHKLRIVKAL-------QANghVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEG 662
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  843 RNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLIS 922
Cdd:COG0474  663 RRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILS 742
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  923 RTMMKNILGHAVYQLAIIFTLLFVGelffdIDSGRNAPLHSppsehyTIIFNTFVMMQLFNEINARKIHgeRNVFD-GIF 1001
Cdd:COG0474  743 RFLLLRILLLGLLIAIFTLLTFALA-----LARGASLALAR------TMAFTTLVLSQLFNVFNCRSER--RSFFKsGLF 809
                        970       980       990      1000      1010
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 48255953 1002 SNPIFCTIVLGTFGIQIVIVQ--FGGKPFSCSPLSTEQWLWCLFVGVGELVWGQVI 1055
Cdd:COG0474  810 PNRPLLLAVLLSLLLQLLLIYvpPLQALFGTVPLPLSDWLLILGLALLYLLLVELV 865
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
70-913 1.40e-169

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 516.78  E-value: 1.40e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   70 GLadNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLsfyappgeeseacgnvsggaedege 149
Cdd:cd02089    1 GL--SEEEAERRLAKYGPNELVEKKKRSPWKKFLEQFKDFMVIVLLAAAVISGVL------------------------- 53
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  150 aeAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRieQEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADG 229
Cdd:cd02089   54 --GEYVDAIVIIAIVILNAVLGFVQEYKAEKALAALKKM--SAPTAKVLRDGKKQEIPARELVPGDIVLLEAGDYVPADG 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  230 VLIQANDLKIDESSLTGESDHVRKSADKDP-----------MLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLgaggee 298
Cdd:cd02089  130 RLIESASLRVEESSLTGESEPVEKDADTLLeedvplgdrknMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLL------ 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  299 eekkdkkgkqqdgamessqtkakkqdgavamemqplksaeggemeerekkkaNAPKKEKSVLQGKLTKLAVQIGKAGLVM 378
Cdd:cd02089  204 ----------------------------------------------------EETEEEKTPLQKRLDQLGKRLAIAALII 231
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  379 SAITVIILVLYfvietfvveGRTWLAEctpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHL 458
Cdd:cd02089  232 CALVFALGLLR---------GEDLLDM------------LLTAVSLAVAAIPEGLPAIVTIVLALGVQRMAKRNAIIRKL 290
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  459 DACETMGNATAICSDKTGTLTTNRMTVVQSY-LGDthykeiPAPSALtpkildllvhaisINSAYTTKILPPEKEGALPR 537
Cdd:cd02089  291 PAVETLGSVSVICSDKTGTLTQNKMTVEKIYtIGD------PTETAL-------------IRAARKAGLDKEELEKKYPR 351
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  538 QvgnktecallgfvldlkrdfqpvrEQIPedklykvytFNSVRKSMSTVIRMPDGgFRLFSKGASEILLKKCTNILNsNG 617
Cdd:cd02089  352 I------------------------AEIP---------FDSERKLMTTVHKDAGK-YIVFTKGAPDVLLPRCTYIYI-NG 396
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  618 ELRGFRPRDRDDmVRKIIEPMACDGLRTICIAYRDFSAGQEPDWDnenEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRA 697
Cdd:cd02089  397 QVRPLTEEDRAK-ILAVNEEFSEEALRVLAVAYKPLDEDPTESSE---DLENDLIFLGLVGMIDPPRPEVKDAVAECKKA 472
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  698 GITVRMVTGDNINTARAIAAKCGIIQPGEdfLCLEGKEFNrrirnekgEIEQERLDKVWPKLRVLARSSPTDKHTLVKGI 777
Cdd:cd02089  473 GIKTVMITGDHKLTARAIAKELGILEDGD--KALTGEELD--------KMSDEELEKKVEQISVYARVSPEHKLRIVKAL 542
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  778 idsttgeQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQF 855
Cdd:cd02089  543 -------QRKgkIVAMTGDGVNDAPALKAADIGVAMGITGTDVAKEAADMILTDDNFATIVAAVEEGRTIYDNIRKFIRY 615
                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 48255953  856 QLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKP 913
Cdd:cd02089  616 LLSGNVGEILTMLLAPLLGWPVPLLPIQLLWINLLTDGLPALALGVEPAEPDIMDRKP 673
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
79-1046 3.86e-150

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 470.98  E-value: 3.86e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   79 EKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFyappgeeseacgnvsggaedegeaeagWIEGA 158
Cdd:cd02080    8 AERLERYGPNRLPEKKTKSPLLRFLRQFNNPLIYILLAAAVVTAFLGH---------------------------WVDAI 60
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  159 AILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQkfTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLK 238
Cdd:cd02080   61 VIFGVVLINAIIGYIQEGKAEKALAAIKNMLSPEA--TVLRDGKKLTIDAEELVPGDIVLLEAGDKVPADLRLIEARNLQ 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  239 IDESSLTGESDHVRKS----------ADKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGgeeeekkdkkgkq 308
Cdd:cd02080  139 IDESALTGESVPVEKQegpleedtplGDRKNMAYSGTLVTAGSATGVVVATGADTEIGRINQLLAEV------------- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  309 qdgamESSQTkakkqdgavamemqplksaeggemeerekkkanaPkkeksvLQGKLTKLAVQIGKAGLVMSAITVIIlvl 388
Cdd:cd02080  206 -----EQLAT----------------------------------P------LTRQIAKFSKALLIVILVLAALTFVF--- 237
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  389 yfvieTFVVEGRTWlaectpvyvqyfVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNAT 468
Cdd:cd02080  238 -----GLLRGDYSL------------VELFMAVVALAVAAIPEGLPAVITITLAIGVQRMAKRNAIIRRLPAVETLGSVT 300
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  469 AICSDKTGTLTTNRMTVVQSYLgdthykeipapsaltpkildllvhaiSINSAYttkiLPPEKEGAlpRQVGNKTECALL 548
Cdd:cd02080  301 VICSDKTGTLTRNEMTVQAIVT--------------------------LCNDAQ----LHQEDGHW--KITGDPTEGALL 348
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  549 GFVLDLKRDFQPVREQIPE-DKLykvyTFNSVRKSMSTVIRMpDGGFRLFSKGASEILLKKCTNILNSNGElrgfRPRDR 627
Cdd:cd02080  349 VLAAKAGLDPDRLASSYPRvDKI----PFDSAYRYMATLHRD-DGQRVIYVKGAPERLLDMCDQELLDGGV----SPLDR 419
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  628 DdMVRKIIEPMACDGLRTICIAYRDFsaGQEPDWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGD 707
Cdd:cd02080  420 A-YWEAEAEDLAKQGLRVLAFAYREV--DSEVEEIDHADLEGGLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKMITGD 496
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  708 NINTARAIAAKCGIIQPGEdflCLEGKEFNRrirnekgeIEQERLDKVWPKLRVLARSSPTDKHTLVKGIidSTTGEqrq 787
Cdd:cd02080  497 HAETARAIGAQLGLGDGKK---VLTGAELDA--------LDDEELAEAVDEVDVFARTSPEHKLRLVRAL--QARGE--- 560
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  788 VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNV---VAV 864
Cdd:cd02080  561 VVAMTGDGVNDAPALKQADIGIAMGIKGTEVAKEAADMVLADDNFATIAAAVEEGRRVYDNLKKFILFTLPTNLgegLVI 640
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  865 IVA-FTGACItqdsPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVYQLAIIFtL 943
Cdd:cd02080  641 IVAiLFGVTL----PLTPVQILWINMVTAITLGLALAFEPAEPGIMKRPPRDPSEPLLSRELIWRILLVSLLMLGGAF-G 715
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  944 LFVGELF--FDIDSGRnaplhsppsehyTIIFNTFVMMQLFNEINARKIHgeRNVFD-GIFSNPIFCTIVLGTFGIQIVI 1020
Cdd:cd02080  716 LFLWALDrgYSLETAR------------TMAVNTIVVAQIFYLFNCRSLH--RSILKlGVFSNKILFLGIGALILLQLAF 781
                        970       980
                 ....*....|....*....|....*...
gi 48255953 1021 VQ--FGGKPFSCSPLSTEQWLWCLFVGV 1046
Cdd:cd02080  782 TYlpFMNSLFGTAPIDLVDWAIILLVGI 809
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
160-899 2.54e-147

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 454.08  E-value: 2.54e-147
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    160 ILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRNGQLlQVPVAALVVGDIAQVKYGDLLPADGVLIQaNDLKI 239
Cdd:TIGR01494    2 ILFLVLLFVLLEVKQKLKAEDALRSLKDSLVNTATVLVLRNGWK-EISSKDLVPGDVVLVKSGDTVPADGVLLS-GSAFV 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    240 DESSLTGESDHVRKSADKDP-MLLSGTHVMEGSGRMVVTAVGVNSQTGIIftllgaggeeeekkdkkgkqqdgamessqt 318
Cdd:TIGR01494   80 DESSLTGESLPVLKTALPDGdAVFAGTINFGGTLIVKVTATGILTTVGKI------------------------------ 129
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    319 kakkqdgAVAMEmqplksaEGGEmeerekkkanapkkEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFvve 398
Cdd:TIGR01494  130 -------AVVVY-------TGFS--------------TKTPLQSKADKFENFIFILFLLLLALAVFLLLPIGGWDGN--- 178
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    399 grtwlaectpvyvqYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTL 478
Cdd:TIGR01494  179 --------------SIYKAILRALAVLVIAIPCALPLAVSVALAVGDARMAKKGILVKNLNALEELGKVDVICFDKTGTL 244
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    479 TTNRMTVVQSYLGDTHYKEIPAPSALTpkildllvhaisinsayttkilppekeGALPRQVGNKTECALLGFVldlKRDF 558
Cdd:TIGR01494  245 TTNKMTLQKVIIIGGVEEASLALALLA---------------------------ASLEYLSGHPLERAIVKSA---EGVI 294
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    559 QpVREQIPEDKLYKVYTFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNILNSNgelrgfrprdrddmvrKIIEPM 638
Cdd:TIGR01494  295 K-SDEINVEYKILDVFPFSSVLKRMGVIVEGANGSDLLFVKGAPEFVLERCNNENDYD----------------EKVDEY 357
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    639 ACDGLRTICIAYRDFSagqepdwdnenevvGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAK 718
Cdd:TIGR01494  358 ARQGLRVLAFASKKLP--------------DDLEFLGLLTFEDPLRPDAKETIEALRKAGIKVVMLTGDNVLTAKAIAKE 423
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    719 CGIIqpgedflclegkefnrrirnekgeieqerldkvwpklrVLARSSPTDKHTLVKGIIdsttgEQRQVVAVTGDGTND 798
Cdd:TIGR01494  424 LGID--------------------------------------VFARVKPEEKAAIVEALQ-----EKGRTVAMTGDGVND 460
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    799 GPALKKADVGFAMGIAgtDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACItqdsp 878
Cdd:TIGR01494  461 APALKKADVGIAMGSG--DVAKAAADIVLLDDDLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLIVI----- 533
                          730       740
                   ....*....|....*....|.
gi 48255953    879 lkavqmlwvNLIMDTFASLAL 899
Cdd:TIGR01494  534 ---------ILLPPLLAALAL 545
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
55-922 2.88e-141

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 452.13  E-value: 2.88e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   55 DVSGLCRRLKTSPTEGLADNtnDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYappgees 134
Cdd:cd02083    4 TVEEVLAYFGVDPTRGLSDE--QVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALF------- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  135 eacgnvsggaEDEGEAEAGWIEGAAILLSVIC--VVLVtafndWskekQFRGLQSRIEQEQKF-----TVIRNGQLLQ-V 206
Cdd:cd02083   75 ----------EEGEEGVTAFVEPFVILLILIAnaVVGV-----W----QERNAEKAIEALKEYepemaKVLRNGKGVQrI 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  207 PVAALVVGDIAQVKYGDLLPADG--VLIQANDLKIDESSLTGESDHVRKSAD--KDP---------MLLSGTHVMEGSGR 273
Cdd:cd02083  136 RARELVPGDIVEVAVGDKVPADIriIEIKSTTLRVDQSILTGESVSVIKHTDvvPDPravnqdkknMLFSGTNVAAGKAR 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  274 MVVTAVGVNSQTGIIFTllgaggeeeekkdkkgkqqdgamessqtkakkqdgavamemqplksaeggEMEEREKkkanap 353
Cdd:cd02083  216 GVVVGTGLNTEIGKIRD--------------------------------------------------EMAETEE------ 239
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  354 kkEKSVLQGKLTKLAVQIGKAglvmsaITVIILVLYFV-IETFV--VEGRTWLAECtpVYvqyfvkFFIIGVTVLVVAVP 430
Cdd:cd02083  240 --EKTPLQQKLDEFGEQLSKV------ISVICVAVWAInIGHFNdpAHGGSWIKGA--IY------YFKIAVALAVAAIP 303
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  431 EGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTV-----VQSYLGDTHYKEIP------ 499
Cdd:cd02083  304 EGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVsrmfiLDKVEDDSSLNEFEvtgsty 383
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  500 --------APSALTPKILDLLVHAISINSAYTTKILPPEKEGALPRQVGNKTECALLGFV------------LDLKRDFQ 559
Cdd:cd02083  384 apegevfkNGKKVKAGQYDGLVELATICALCNDSSLDYNESKGVYEKVGEATETALTVLVekmnvfntdksgLSKRERAN 463
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  560 PVREQIpEDKLYKVYT--FNSVRKSMSTVIR--MPDGGFRLFSKGASEILLKKCTNILNSNGELRGFRPRDRDDMVRKII 635
Cdd:cd02083  464 ACNDVI-EQLWKKEFTleFSRDRKSMSVYCSptKASGGNKLFVKGAPEGVLERCTHVRVGGGKVVPLTAAIKILILKKVW 542
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  636 EpMACDGLRTICIAYRDFSAGQEP----DWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINT 711
Cdd:cd02083  543 G-YGTDTLRCLALATKDTPPKPEDmdleDSTKFYKYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGT 621
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  712 ARAIAAKCGIIQPGEDFlclEGKEFNRRIRNEKGEIEQErldKVWPKLRVLARSSPTDKHTLVKGIidsttGEQRQVVAV 791
Cdd:cd02083  622 AEAICRRIGIFGEDEDT---TGKSYTGREFDDLSPEEQR---EACRRARLFSRVEPSHKSKIVELL-----QSQGEITAM 690
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  792 TGDGTNDGPALKKADVGFAMGIaGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGA 871
Cdd:cd02083  691 TGDGVNDAPALKKAEIGIAMGS-GTAVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTA 769
                        890       900       910       920       930
                 ....*....|....*....|....*....|....*....|....*....|.
gi 48255953  872 CITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLIS 922
Cdd:cd02083  770 ALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMKKPPRKPDEPLIS 820
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
102-1044 1.89e-128

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 416.11  E-value: 1.89e-128
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    102 VWEALQDVTLIILEVAAIVSLGLSFYappgeeseacgnvsggaEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQ 181
Cdd:TIGR01116    1 VLEQFEDLLVRILLLAACVSFVLAWF-----------------EEGEETVTAFVEPFVILLILVANAIVGVWQERNAEKA 63
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    182 FRGLQSrIEQEQKfTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLKIDESSLTGESDHVRKSA------ 255
Cdd:TIGR01116   64 IEALKE-YESEHA-KVLRDGRWSVIKAKDLVPGDIVELAVGDKVPADIRVLSLKTLRVDQSILTGESVSVNKHTesvpde 141
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    256 -----DKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIftllgaggeeeekkdkkgkqqdgamessqtkakkQDgavame 330
Cdd:TIGR01116  142 ravnqDKKNMLFSGTLVVAGKARGVVVRTGMSTEIGKI----------------------------------RD------ 181
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    331 mqplksaeggEMEEREKkkanapkkEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFviETFVVEGRtwlaectpvY 410
Cdd:TIGR01116  182 ----------EMRAAEQ--------EDTPLQKKLDEFGELLSKVIGLICILVWVINIGHF--NDPALGGG---------W 232
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    411 VQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTV----- 485
Cdd:TIGR01116  233 IQGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTTVICSDKTGTLTTNQMSVckvva 312
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    486 -------VQSY-LGDTHYKEIPA----PSALTPKILDLLVHAISINSAYTTKILPPEKEGALPRQVGNKTECALLGFV-- 551
Cdd:TIGR01116  313 ldpssssLNEFcVTGTTYAPEGGvikdDGPVAGGQDAGLEELATIAALCNDSSLDFNERKGVYEKVGEATEAALKVLVek 392
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    552 ---LDLKRDFQPVRE------QIPEDKLYKVYT--FNSVRKSMStVIRMPDGGFRLFSKGASEILLKKCTNILNSNGELR 620
Cdd:TIGR01116  393 mglPATKNGVSSKRRpalgcnSVWNDKFKKLATleFSRDRKSMS-VLCKPSTGNKLFVKGAPEGVLERCTHILNGDGRAV 471
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    621 GFRPRDRDDMVRKIIEPMACDGLRTICIAYRDFSAGQE----PDWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQR 696
Cdd:TIGR01116  472 PLTDKMKNTILSVIKEMGTTKALRCLALAFKDIPDPREedllSDPANFEAIESDLTFIGVVGMLDPPRPEVADAIEKCRT 551
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    697 AGITVRMVTGDNINTARAIAAKCGIIQPGED--FLCLEGKEFNrrirnekgEIEQERLDKVWPKLRVLARSSPTDKHTLV 774
Cdd:TIGR01116  552 AGIRVIMITGDNKETAEAICRRIGIFSPDEDvtFKSFTGREFD--------EMGPAKQRAACRSAVLFSRVEPSHKSELV 623
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    775 KgiidsTTGEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQ 854
Cdd:TIGR01116  624 E-----LLQEQGEIVAMTGDGVNDAPALKKADIGIAMG-SGTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIR 697
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    855 FQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLIS-----RTMMKNI 929
Cdd:TIGR01116  698 YMISSNIGEVVCIFLTAALGIPEGLIPVQLLWVNLVTDGLPATALGFNPPDKDIMWKPPRRPDEPLITgwlffRYLVVGV 777
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    930 LGHAVYQLAIIFTLLFVGELFFDIDSGRNAP--------LHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFdGIF 1001
Cdd:TIGR01116  778 YVGLATVGGFVWWYLLTHFTGCDEDSFTTCPdfedpdcyVFEGKQPARTISLSVLVVIEMFNALNALSEDQSLLRM-PPW 856
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....*
gi 48255953   1002 SNPIFCTIVLGTFGIQIVI--VQFGGKPFSCSPLSTEQWLWCLFV 1044
Cdd:TIGR01116  857 VNKWLIGAICLSMALHFLIlyVPFLSRIFGVTPLSLTDWLMVLKL 901
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
81-1023 9.22e-122

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 394.84  E-value: 9.22e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   81 RRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLglsfyappgeeseacgnVSGGAEDegeaeagwieGAAI 160
Cdd:cd02085    1 RRKLHGPNEFKVEDEEPLWKKYLEQFKNPLILLLLGSAVVSV-----------------VMKQYDD----------AVSI 53
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  161 LLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEqkFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLKID 240
Cdd:cd02085   54 TVAILIVVTVAFVQEYRSEKSLEALNKLVPPE--CHCLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLSID 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  241 ESSLTGESDHVRKS------------ADKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFtllgaggeeeekkdkkgkq 308
Cdd:cd02085  132 ESSLTGETEPCSKTtevipkasngdlTTRSNIAFMGTLVRCGHGKGIVIGTGENSEFGEVF------------------- 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  309 qdgamessqtkakkqdgavamemqplksaeggemeerekKKANAPKKEKSVLQGKLTKLAVQigkaglvMSAITVIILVL 388
Cdd:cd02085  193 ---------------------------------------KMMQAEEAPKTPLQKSMDKLGKQ-------LSLYSFIIIGV 226
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  389 YFVIETFvvEGRTWLaectpvyvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNAT 468
Cdd:cd02085  227 IMLIGWL--QGKNLL------------EMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVN 292
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  469 AICSDKTGTLTTNRMTVVQsylgdthykeipapsaltpkildlLVHAISINSAYTTKILPPekegalprqvGNKTECALL 548
Cdd:cd02085  293 VICSDKTGTLTKNEMTVTK------------------------IVTGCVCNNAVIRNNTLM----------GQPTEGALI 338
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  549 gfVLDLKRDFQPVREQIpedKLYKVYTFNSVRKSMSTVIRMPDGGFR---LFSKGASEILLKKCTNILNSNGELRGFRPR 625
Cdd:cd02085  339 --ALAMKMGLSDIRETY---IRKQEIPFSSEQKWMAVKCIPKYNSDNeeiYFMKGALEQVLDYCTTYNSSDGSALPLTQQ 413
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  626 DRDdMVRKIIEPMACDGLRTICIAyrdfsAGQEpdwdnenevVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVT 705
Cdd:cd02085  414 QRS-EINEEEKEMGSKGLRVLALA-----SGPE---------LGDLTFLGLVGINDPPRPGVREAIQILLESGVRVKMIT 478
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  706 GDNINTARAIAAKCGIIQPGEdfLCLEGKEFNRrirnekgeIEQERLDKVWPKLRVLARSSPTDKHTLVKGIidSTTGEq 785
Cdd:cd02085  479 GDAQETAIAIGSSLGLYSPSL--QALSGEEVDQ--------MSDSQLASVVRKVTVFYRASPRHKLKIVKAL--QKSGA- 545
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  786 rqVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVI 865
Cdd:cd02085  546 --VVAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEEGKGIFYNIKNFVRFQLSTSIAALS 623
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  866 VAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAvyqlAIIF--TL 943
Cdd:cd02085  624 LIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPILTRSLILNVLLSA----AIIVsgTL 699
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  944 -LFVGELFFDIDSGRNAplhsppsehyTIIFNTFVMMQLFNEINARkiHGERNVFD-GIFSNPIFCTIVLGTFGIQIVIV 1021
Cdd:cd02085  700 wVFWKEMSDDNVTPRDT----------TMTFTCFVFFDMFNALSCR--SQTKSIFEiGFFSNRMFLYAVGGSLIGQLLVI 767

                 ..
gi 48255953 1022 QF 1023
Cdd:cd02085  768 YF 769
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
154-1020 4.31e-117

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 385.66  E-value: 4.31e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  154 WIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKftVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQ 233
Cdd:cd02086   56 WIEGGVIAAVIALNVIVGFIQEYKAEKTMDSLRNLSSPNAH--VIRSGKTETISSKDVVPGDIVLLKVGDTVPADLRLIE 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  234 ANDLKIDESSLTGESDHVRKSA-------------DKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLgaggeeee 300
Cdd:cd02086  134 TKNFETDEALLTGESLPVIKDAelvfgkeedvsvgDRLNLAYSSSTVTKGRAKGIVVATGMNTEIGKIAKAL-------- 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  301 kkdkkgkqqdgamessQTKAKKQDgavameMQPLKSAEGGEMEEREKKKANA-PKKEKSVLQGKLTKLAVqigkaglVMS 379
Cdd:cd02086  206 ----------------RGKGGLIS------RDRVKSWLYGTLIVTWDAVGRFlGTNVGTPLQRKLSKLAY-------LLF 256
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  380 AITVIILVLYFVIETFVVEGRTwlaectpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLD 459
Cdd:cd02086  257 FIAVILAIIVFAVNKFDVDNEV----------------IIYAIALAISMIPESLVAVLTITMAVGAKRMVKRNVIVRKLD 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  460 ACETMGNATAICSDKTGTLTTNRMTVVQSYLgdthykeipaPSALTpkildllvhaisiNSAYTTKilppEKEGALPRQV 539
Cdd:cd02086  321 ALEALGAVTDICSDKTGTLTQGKMVVRQVWI----------PAALC-------------NIATVFK----DEETDCWKAH 373
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  540 GNKTECALLGFV--LDLKRDFQPVREQiPEDKLYKVYTFNSVRKSMSTVIRMPDGGFR-LFSKGASEILLKKCTNILNSN 616
Cdd:cd02086  374 GDPTEIALQVFAtkFDMGKNALTKGGS-AQFQHVAEFPFDSTVKRMSVVYYNNQAGDYyAYMKGAVERVLECCSSMYGKD 452
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  617 GELrgfrPRDRDDM--VRKIIEPMACDGLRTICIAYRDFSAGQEpdWDNENEVVG--------DLTCIAVVGIEDPVRPE 686
Cdd:cd02086  453 GII----PLDDEFRktIIKNVESLASQGLRVLAFASRSFTKAQF--NDDQLKNITlsradaesDLTFLGLVGIYDPPRNE 526
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  687 VPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGE--------DFLCLEGKEFNRRIRNEKGEIEQERLdkvwpk 758
Cdd:cd02086  527 SAGAVEKCHQAGITVHMLTGDHPGTAKAIAREVGILPPNSyhysqeimDSMVMTASQFDGLSDEEVDALPVLPL------ 600
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  759 lrVLARSSPTDKHTLVKGIidsttGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKA 838
Cdd:cd02086  601 --VIARCSPQTKVRMIEAL-----HRRKKFCAMTGDGVNDSPSLKMADVGIAMGLNGSDVAKDASDIVLTDDNFASIVNA 673
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  839 VMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDS-----PLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKP 913
Cdd:cd02086  674 IEEGRRMFDNIQKFVLHLLAENVAQVILLLIGLAFKDEDglsvfPLSPVEILWINMVTSSFPAMGLGLEKASPDVMQRPP 753
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  914 YGRDKPLISRTMMKNILghaVYQLAIIFTLL--FVGELFF----DIDSGRNAPLHSPPSEHY---TIIFNTFVMMQLF-- 982
Cdd:cd02086  754 HDLKVGIFTRELIIDTF---VYGTFMGVLCLasFTLVIYGigngDLGSDCNESYNSSCEDVFrarAAVFATLTWCALIla 830
                        890       900       910       920
                 ....*....|....*....|....*....|....*....|....*....
gi 48255953  983 -NEINARK----IHGE-----RNVFDGIFSNP-IFCTIVLGTFGIQIVI 1020
Cdd:cd02086  831 wEVVDMRRsffnMHPDtdspvKSFFKTLWKNKfLFWSVVLGFVSVFPTL 879
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
470-899 1.56e-97

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 313.23  E-value: 1.56e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  470 ICSDKTGTLTTNRMTVVqsylgDTHYKEIPapsaltpkildllvhaisinsayttkilppekegalprqvgnktecallg 549
Cdd:cd01431    2 ICSDKTGTLTKNGMTVT-----KLFIEEIP-------------------------------------------------- 26
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  550 fvldlkrdfqpvreqipedklykvytFNSVRKSMSTVIRMPdGGFRLFSKGASEILLKKCTNILnsngelrgfrPRDRDD 629
Cdd:cd01431   27 --------------------------FNSTRKRMSVVVRLP-GRYRAIVKGAPETILSRCSHAL----------TEEDRN 69
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  630 MVRKIIEPMACDGLRTICIAYRDFSAGQepdwdNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNI 709
Cdd:cd01431   70 KIEKAQEESAREGLRVLALAYREFDPET-----SKEAVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNP 144
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  710 NTARAIAAKCGIIQPGEDFLCLEgkefnrrirnEKGEIEQERLDKVWPKLRVLARSSPTDKHTLVKGIIDSTtgeqrQVV 789
Cdd:cd01431  145 LTAIAIAREIGIDTKASGVILGE----------EADEMSEEELLDLIAKVAVFARVTPEQKLRIVKALQARG-----EVV 209
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  790 AVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFT 869
Cdd:cd01431  210 AMTGDGVNDAPALKQADVGIAMGSTGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDNIKKNITYLLANNVAEVFAIAL 289
                        410       420       430
                 ....*....|....*....|....*....|
gi 48255953  870 GACITQDSPLKAVQMLWVNLIMDTFASLAL 899
Cdd:cd01431  290 ALFLGGPLPLLAFQILWINLVTDLIPALAL 319
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
79-936 6.15e-96

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 320.54  E-value: 6.15e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   79 EKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLsfyappgeeseacgnvsggaedeGEAEagwiEGA 158
Cdd:cd07538    8 RRRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALIYFVL-----------------------GDPR----EGL 60
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  159 AILLSVICVVLVTAFNDWSKEKQFRGLqsRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLK 238
Cdd:cd07538   61 ILLIFVVVIIAIEVVQEWRTERALEAL--KNLSSPRATVIRDGRERRIPSRELVPGDLLILGEGERIPADGRLLENDDLG 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  239 IDESSLTGESDHVRKSAD----------KDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIftllgaggeeeekkdkkgKQ 308
Cdd:cd07538  139 VDESTLTGESVPVWKRIDgkamsapggwDKNFCYAGTLVVRGRGVAKVEATGSRTELGKI------------------GK 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  309 QDGAMESSQTKAKKQdgavamemqplksaeggemeerekkkanapkkeksvlQGKLTKLavqIGKAGLVMSAITVIilvL 388
Cdd:cd07538  201 SLAEMDDEPTPLQKQ-------------------------------------TGRLVKL---CALAALVFCALIVA---V 237
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  389 YFVIETFVVEGrtwlaectpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNAT 468
Cdd:cd07538  238 YGVTRGDWIQA------------------ILAGITLAMAMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAVETLGSIT 299
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  469 AICSDKTGTLTTNRMTVVQSYLgdthykeipapsaltpkildllvhaisinsayttkilppekegalprqvgnktecall 548
Cdd:cd07538  300 VLCVDKTGTLTKNQMEVVELTS---------------------------------------------------------- 321
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  549 gfvldlkrdfqPVREqipedklykvYTFNSVRKSMSTVIRMPDGGFrLFSKGASEILLKKCTnilnsngelrgFRPRDRD 628
Cdd:cd07538  322 -----------LVRE----------YPLRPELRMMGQVWKRPEGAF-AAAKGSPEAIIRLCR-----------LNPDEKA 368
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  629 DMVRKIIEpMACDGLRTICIAYRDFSAGQEPD--WDNENEVVGdltciaVVGIEDPVRPEVPEAIRKCQRAGITVRMVTG 706
Cdd:cd07538  369 AIEDAVSE-MAGEGLRVLAVAACRIDESFLPDdlEDAVFIFVG------LIGLADPLREDVPEAVRICCEAGIRVVMITG 441
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  707 DNINTARAIAAKCGI-----IQPGEDFLCLEGKEFNRRIRNekgeieqerldkvwpkLRVLARSSPTDKHTLVKGIidST 781
Cdd:cd07538  442 DNPATAKAIAKQIGLdntdnVITGQELDAMSDEELAEKVRD----------------VNIFARVVPEQKLRIVQAF--KA 503
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  782 TGEqrqVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNV 861
Cdd:cd07538  504 NGE---IVAMTGDGVNDAPALKAAHIGIAMGKRGTDVAREASDIVLLDDNFSSIVSTIRLGRRIYDNLKKAITYVFAIHV 580
                        810       820       830       840       850       860       870
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 48255953  862 VAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLISrtmmKNILGHAVYQ 936
Cdd:cd07538  581 PIAGLALLPPLLGLPPLLFPVHVVLLELIIDPTCSIVFEAEPAERDIMRRPPRPPDEPLFG----PRLVIKAILQ 651
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
159-946 3.49e-95

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 325.07  E-value: 3.49e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  159 AILLSVicVVLVTAFNDWSKEKQfrglQSRIEQE------QKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLI 232
Cdd:cd02608   72 GIVLAA--VVIVTGCFSYYQEAK----SSKIMDSfknmvpQQALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRII 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  233 QANDLKIDESSLTGESDHVRKSAD---KDPM------LLSgTHVMEGSGRMVVTAVGVNSQTGIIFTLlgaggeeeekkd 303
Cdd:cd02608  146 SAHGCKVDNSSLTGESEPQTRSPEfthENPLetkniaFFS-TNCVEGTARGIVINTGDRTVMGRIATL------------ 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  304 kkgkqqdgamessqtkakkqdgavamemqplksAEGGEMEErekkkanapkkeksvlqgklTKLAVQIGKAGLVMSAITV 383
Cdd:cd02608  213 ---------------------------------ASGLEVGK--------------------TPIAREIEHFIHIITGVAV 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  384 IILVLYFVIEtfVVEGRTWLAECtpvyvqyfvkFFIIGVtvlVVA-VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACE 462
Cdd:cd02608  240 FLGVSFFILS--LILGYTWLEAV----------IFLIGI---IVAnVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVE 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  463 TMGNATAICSDKTGTLTTNRMTVV----------------QSylGDTHYKEIPAPSALTpKILDLlvhaisINSAyttKI 526
Cdd:cd02608  305 TLGSTSTICSDKTGTLTQNRMTVAhmwfdnqiheadttedQS--GASFDKSSATWLALS-RIAGL------CNRA---EF 372
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  527 LPPEKEGALPRQV--GNKTECALLGF-------VLDLKRDFQPVREqIPedklykvytFNSVRK---SMSTVIRMPDGGF 594
Cdd:cd02608  373 KAGQENVPILKRDvnGDASESALLKCielscgsVMEMRERNPKVAE-IP---------FNSTNKyqlSIHENEDPGDPRY 442
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  595 RLFSKGASEILLKKCTNILNSNGELrgfrprDRDDMVRKIIEP--MACDGLRTICIAYRD-------FSAGQEPDWDNEN 665
Cdd:cd02608  443 LLVMKGAPERILDRCSTILINGKEQ------PLDEEMKEAFQNayLELGGLGERVLGFCHlylpddkFPEGFKFDTDEVN 516
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  666 EVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIqpgedflclegkefnrrirnekg 745
Cdd:cd02608  517 FPTENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGII----------------------- 573
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  746 eieqerldkvwpklrVLARSSPTDKHTLVKGIidsttgeQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEAS 823
Cdd:cd02608  574 ---------------VFARTSPQQKLIIVEGC-------QRQgaIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAA 631
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  824 DIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNvVAVIVAFTgACITQDSPLK--AVQMLWVNLIMDTFASLALAT 901
Cdd:cd02608  632 DMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSN-IPEITPFL-IFIIANIPLPlgTITILCIDLGTDMVPAISLAY 709
                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|
gi 48255953  902 EPPTESLLLRKPygRDkPLISRTMMKNILGHAVYQLAII-----FTLLFV 946
Cdd:cd02608  710 EKAESDIMKRQP--RN-PKTDKLVNERLISMAYGQIGMIqalagFFTYFV 756
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
193-935 5.27e-91

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 315.58  E-value: 5.27e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    193 QKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLKIDESSLTGESDHVRKSAD---KDPM-----LLSG 264
Cdd:TIGR01106  141 QQALVIRDGEKMSINAEQVVVGDLVEVKGGDRIPADLRIISAQGCKVDNSSLTGESEPQTRSPEfthENPLetrniAFFS 220
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    265 THVMEGSGRMVVTAVGVNSQTGIIFTLlgaggeeeekkdkkgkqqdgamessqtkakkqdgavamemqplksAEGgemee 344
Cdd:TIGR01106  221 TNCVEGTARGIVVNTGDRTVMGRIASL---------------------------------------------ASG----- 250
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    345 rekkkanapkkeksvLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIEtfVVEGRTWLAECtpvyvqyfvkFFIIGVtv 424
Cdd:TIGR01106  251 ---------------LENGKTPIAIEIEHFIHIITGVAVFLGVSFFILS--LILGYTWLEAV----------IFLIGI-- 301
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    425 LVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYL-------------- 490
Cdd:TIGR01106  302 IVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFdnqiheadttedqs 381
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    491 GDTHYKEIPAPSALTpKILDLLVHAIsinsayttkiLPPEKEGA--LPRQV-GNKTECALLGF-------VLDLKRDFQP 560
Cdd:TIGR01106  382 GVSFDKSSATWLALS-RIAGLCNRAV----------FKAGQENVpiLKRAVaGDASESALLKCielclgsVMEMRERNPK 450
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    561 VREqIPedklykvytFNSVRKSMSTVIRMPDGG---FRLFSKGASEILLKKCTNILNSNGELrgfrPRDRDdmVRKIIEP 637
Cdd:TIGR01106  451 VVE-IP---------FNSTNKYQLSIHENEDPRdprHLLVMKGAPERILERCSSILIHGKEQ----PLDEE--LKEAFQN 514
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    638 --MACDGL--RTI--CIAY---RDFSAGQEPDWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDN 708
Cdd:TIGR01106  515 ayLELGGLgeRVLgfCHLYlpdEQFPEGFQFDTDDVNFPTDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDH 594
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    709 INTARAIAAKCGIIQPG----EDF---LCLEGKEFNRRIRN-------EKGEIEQERLDKVwpkLR-----VLARSSPTD 769
Cdd:TIGR01106  595 PITAKAIAKGVGIISEGnetvEDIaarLNIPVSQVNPRDAKacvvhgsDLKDMTSEQLDEI---LKyhteiVFARTSPQQ 671
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    770 KHTLVKGIidsttgeQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYD 847
Cdd:TIGR01106  672 KLIIVEGC-------QRQgaIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFD 744
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    848 SISKFLQFQLTVNV--VAVIVAFTGACITQdsPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYG--RDK----P 919
Cdd:TIGR01106  745 NLKKSIAYTLTSNIpeITPFLIFIIANIPL--PLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQPRNpkTDKlvneR 822
                          810       820
                   ....*....|....*....|.
gi 48255953    920 LISRT-----MMKNILGHAVY 935
Cdd:TIGR01106  823 LISMAygqigMIQALGGFFTY 843
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
158-902 5.60e-91

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 306.26  E-value: 5.60e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  158 AAILLSVICV-VLVTAFNDWSKEKQFRGLqsRIEQEQKFTVIR--NGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQA 234
Cdd:cd07539   60 AVLIVGVLTVnAVIGGVQRLRAERALAAL--LAQQQQPARVVRapAGRTQTVPAESLVPGDVIELRAGEVVPADARLLEA 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  235 NDLKIDESSLTGESDHVRKS---------ADKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAggeeeekkdkk 305
Cdd:cd07539  138 DDLEVDESALTGESLPVDKQvaptpgaplADRACMLYEGTTVVSGQGRAVVVATGPHTEAGRAQSLVAP----------- 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  306 gkqqdgamESSQTKAKKQDGAVAMEMQPLKSAEGGemeerekkkanapkkeksvlqgKLTKLAVQIGKAGLVMSAItvii 385
Cdd:cd07539  207 --------VETATGVQAQLRELTSQLLPLSLGGGA----------------------AVTGLGLLRGAPLRQAVAD---- 252
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  386 lvlyfvietfvvegrtwlaectpvyvqyfvkffiiGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMG 465
Cdd:cd07539  253 -----------------------------------GVSLAVAAVPEGLPLVATLAQLAAARRLSRRGVLVRSPRTVEALG 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  466 NATAICSDKTGTLTTNRMTVVQsylgdthykeipapsaltpkildllvhaisinsayttkilppekegalprqvgnktec 545
Cdd:cd07539  298 RVDTICFDKTGTLTENRLRVVQ---------------------------------------------------------- 319
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  546 allgfvldlkrdFQPVREQIPedklykvytFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNILnSNGELRGFRPR 625
Cdd:cd07539  320 ------------VRPPLAELP---------FESSRGYAAAIGRTGGGIPLLAVKGAPEVVLPRCDRRM-TGGQVVPLTEA 377
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  626 DRDdMVRKIIEPMACDGLRTICIAYRDFSAGQEPDWDNeneVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVT 705
Cdd:cd07539  378 DRQ-AIEEVNELLAGQGLRVLAVAYRTLDAGTTHAVEA---VVDDLELLGLLGLADTARPGAAALIAALHDAGIDVVMIT 453
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  706 GDNINTARAIAAKCGIIQPGEdflCLEGKEFNRrirnekgeIEQERLDKVWPKLRVLARSSPTDKHTLVKGIIDSTTgeq 785
Cdd:cd07539  454 GDHPITARAIAKELGLPRDAE---VVTGAELDA--------LDEEALTGLVADIDVFARVSPEQKLQIVQALQAAGR--- 519
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  786 rqVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVI 865
Cdd:cd07539  520 --VVAMTGDGANDAAAIRAADVGIGVGARGSDAAREAADLVLTDDDLETLLDAVVEGRTMWQNVRDAVHVLLGGNLGEVM 597
                        730       740       750
                 ....*....|....*....|....*....|....*..
gi 48255953  866 VAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATE 902
Cdd:cd07539  598 FTLIGTAIGGGAPLNTRQLLLVNLLTDMFPALALAVE 634
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
63-957 2.04e-83

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 294.61  E-value: 2.04e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953     63 LKTSPTEGLADNtnDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSfyappgeeseacgnvsg 142
Cdd:TIGR01523   19 IGTSIPEGLTHD--EAQHRLKEVGENRLEADSGIDAKAMLLHQVCNAMCMVLIIAAAISFAMH----------------- 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    143 gaedegeaeaGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKftVIRNGQLLQVPVAALVVGDIAQVKYG 222
Cdd:TIGR01523   80 ----------DWIEGGVISAIIALNILIGFIQEYKAEKTMDSLKNLASPMAH--VIRNGKSDAIDSHDLVPGDICLLKTG 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    223 DLLPADGVLIQANDLKIDESSLTGESDHVRKSA-------------DKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIf 289
Cdd:TIGR01523  148 DTIPADLRLIETKNFDTDEALLTGESLPVIKDAhatfgkeedtpigDRINLAFSSSAVTKGRAKGICIATALNSEIGAI- 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    290 tllgaggeeeekkdkkgkqqdgamessqTKAKKQDGAVamemqpLKSAEGGEMEEREKKKANAPKKEKSV---------- 359
Cdd:TIGR01523  227 ----------------------------AAGLQGDGGL------FQRPEKDDPNKRRKLNKWILKVTKKVtgaflglnvg 272
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    360 --LQGKLTKLAVqigkaglVMSAITVIILVLYFVIETFVVEGRTwlaectpvyvqyfvkfFIIGVTVLVVAVPEGLPLAV 437
Cdd:TIGR01523  273 tpLHRKLSKLAV-------ILFCIAIIFAIIVMAAHKFDVDKEV----------------AIYAICLAISIIPESLIAVL 329
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    438 TISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIP-APSALTPK------ILD 510
Cdd:TIGR01523  330 SITMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMIARQIWIPRFGTISIDnSDDAFNPNegnvsgIPR 409
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    511 LLVHAISINSAYTTKILPPEK----EGALPRQV--------------------------------GNKTECALLGFV--L 552
Cdd:TIGR01523  410 FSPYEYSHNEAADQDILKEFKdelkEIDLPEDIdmdlfiklletaalaniatvfkddatdcwkahGDPTEIAIHVFAkkF 489
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    553 DLKRDFQPVREQI--------------------PEDKLYKVYTFNSVRKSMSTVIRMPDG-GFRLFSKGASEILLKKCTN 611
Cdd:TIGR01523  490 DLPHNALTGEEDLlksnendqsslsqhnekpgsAQFEFIAEFPFDSEIKRMASIYEDNHGeTYNIYAKGAFERIIECCSS 569
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    612 ILNSNG-ELRGFRPRDRDdMVRKIIEPMACDGLRTICIAYRDFSAGQEPDWDNENEVV------GDLTCIAVVGIEDPVR 684
Cdd:TIGR01523  570 SNGKDGvKISPLEDCDRE-LIIANMESLAAEGLRVLAFASKSFDKADNNDDQLKNETLnrataeSDLEFLGLIGIYDPPR 648
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    685 PEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGII--------QPGEDFLCLEGKEFNrrirnekgEIEQERLDKVW 756
Cdd:TIGR01523  649 NESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGIIppnfihdrDEIMDSMVMTGSQFD--------ALSDEEVDDLK 720
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    757 PKLRVLARSSPTDKHTLVKGIidsttGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIV 836
Cdd:TIGR01523  721 ALCLVIARCAPQTKVKMIEAL-----HRRKAFCAMTGDGVNDSPSLKMANVGIAMGINGSDVAKDASDIVLSDDNFASIL 795
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    837 KAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDS-----PLKAVQMLWVNLIMDTFASLALATEPPTESLLLR 911
Cdd:TIGR01523  796 NAIEEGRRMFDNIMKFVLHLLAENVAEAILLIIGLAFRDENgksvfPLSPVEILWCIMITSCFPAMGLGLEKAAPDLMDR 875
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....*.
gi 48255953    912 KPYGRDKPLISRTMMKNILGHAVYqLAIIFTLLFVGELfFDIDSGR 957
Cdd:TIGR01523  876 LPHDNEVGIFQKELIIDMFAYGFF-LGGSCLASFTGIL-YGFGSGN 919
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
74-913 3.57e-79

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 276.82  E-value: 3.57e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   74 NTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYAPPGEESeacgnvsggaedegeaeag 153
Cdd:cd02077    3 TNEEAEERLEKYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSFFTDVLLAPGEFD------------------- 63
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  154 wIEGAAILLS-VICVVLVTAFNDWSKEKQFRGLQSRIEQeqKFTVIRNGQL-LQVPVAALVVGDIAQVKYGDLLPADGVL 231
Cdd:cd02077   64 -LVGALIILLmVLISGLLDFIQEIRSLKAAEKLKKMVKN--TATVIRDGSKyMEIPIDELVPGDIVYLSAGDMIPADVRI 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  232 IQANDLKIDESSLTGESDHVRKSA-----------DKDPMLLSGTHVMEGSGRMVVTAVGVNsqtgiifTLLGaggeeee 300
Cdd:cd02077  141 IQSKDLFVSQSSLTGESEPVEKHAtakktkdesilELENICFMGTNVVSGSALAVVIATGND-------TYFG------- 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  301 kkdkkgkqqdgamessqTKAKKqdgavAMEMQPLKSAEGGEMeerekkkanapkkeksvlqgKLTKLavqigkaglVMSA 380
Cdd:cd02077  207 -----------------SIAKS-----ITEKRPETSFDKGIN--------------------KVSKL---------LIRF 235
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  381 ITVIILVLYFVIetfVVEGRTWLaectpvyvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDA 460
Cdd:cd02077  236 MLVMVPVVFLIN---GLTKGDWL------------EALLFALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIVKNLNA 300
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  461 CETMGNATAICSDKTGTLTTNRMTVVQSYlgDTHYKEipapsalTPKILDLLVhaisINSAYTTKILPPekegaLPRQVG 540
Cdd:cd02077  301 IQNFGAMDILCTDKTGTLTQDKIVLERHL--DVNGKE-------SERVLRLAY----LNSYFQTGLKNL-----LDKAII 362
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  541 NKTECALLGFvldLKRDFQPVREqIPedklykvytFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNIlNSNGELR 620
Cdd:cd02077  363 DHAEEANANG---LIQDYTKIDE-IP---------FDFERRRMSVVVKDNDGKHLLITKGAVEEILNVCTHV-EVNGEVV 428
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  621 GFRPRDRdDMVRKIIEPMACDGLRTICIAYRDFSAgqePDWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGIT 700
Cdd:cd02077  429 PLTDTLR-EKILAQVEELNREGLRVLAIAYKKLPA---PEGEYSVKDEKELILIGFLAFLDPPKESAAQAIKALKKNGVN 504
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  701 VRMVTGDNINTARAIAAKCGiIQPGEdflCLEGKEFNrrirnekgEIEQERLDKVWPKLRVLARSSPTDKHTlvkgIIDS 780
Cdd:cd02077  505 VKILTGDNEIVTKAICKQVG-LDINR---VLTGSEIE--------ALSDEELAKIVEETNIFAKLSPLQKAR----IIQA 568
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  781 TTgEQRQVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVN 860
Cdd:cd02077  569 LK-KNGHVVGFMGDGINDAPALRQADVGISVDSA-VDIAKEAADIILLEKDLMVLEEGVIEGRKTFGNILKYIKMTASSN 646
                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 48255953  861 ---VVAVIVAftgACITQDSPLKAVQMLWVNLIMDtFASLALATEPPTESlLLRKP 913
Cdd:cd02077  647 fgnVFSVLVA---SAFLPFLPMLPIQLLLQNLLYD-FSQLAIPFDNVDEE-FLKKP 697
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
75-1051 4.64e-78

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 274.11  E-value: 4.64e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   75 TNDLEKRRQIYGQNFIPPKQP---KTFLQLVWEALQdvtlIILEVAAIVSLGLsfyappgeeseacgnvsggaedegeae 151
Cdd:cd02076    4 SEEAAKRLKEYGPNELPEKKEnpiLKFLSFFWGPIP----WMLEAAAILAAAL--------------------------- 52
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  152 AGWIEGAAILLsvicVVLVTAFNDWSKEKQFRGLQSRIEQ--EQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADG 229
Cdd:cd02076   53 GDWVDFAIILL----LLLINAGIGFIEERQAGNAVAALKKslAPKARVLRDGQWQEIDAKELVPGDIVSLKIGDIVPADA 128
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  230 VLIQANDLKIDESSLTGESDHVRKSadKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGaggeeeekkdkkgkqq 309
Cdd:cd02076  129 RLLTGDALQVDQSALTGESLPVTKH--PGDEAYSGSIVKQGEMLAVVTATGSNTFFGKTAALVA---------------- 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  310 dgamessqtkakkqdgavamemqplkSAEGgemeerekkkanapkkeksvlQGKLTKLAVQIGKAGLVMSAITV--IILV 387
Cdd:cd02076  191 --------------------------SAEE---------------------QGHLQKVLNKIGNFLILLALILVliIVIV 223
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  388 LYFVIETFVvegrtwlaectpvyvqYFVKFFIIgvtVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNA 467
Cdd:cd02076  224 ALYRHDPFL----------------EILQFVLV---LLIASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSAIEELAGV 284
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  468 TAICSDKTGTLTTNRMTVVQSYLGDTHYKEipapsaltpkilDLLVHAisinsAYTTKilpPEKEGALPRqvgnktecAL 547
Cdd:cd02076  285 DILCSDKTGTLTLNKLSLDEPYSLEGDGKD------------ELLLLA-----ALASD---TENPDAIDT--------AI 336
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  548 LGFVLDLKRDfqpvreqIPEDKLYKVYTFNSVRK-SMSTVIRmPDGGFRLFSKGASEILLKKCTNilnsngelrgfrPRD 626
Cdd:cd02076  337 LNALDDYKPD-------LAGYKQLKFTPFDPVDKrTEATVED-PDGERFKVTKGAPQVILELVGN------------DEA 396
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  627 RDDMVRKIIEPMACDGLRTICIAYRDfsagQEPDWdnenEVVGDLTCIavvgieDPVRPEVPEAIRKCQRAGITVRMVTG 706
Cdd:cd02076  397 IRQAVEEKIDELASRGYRSLGVARKE----DGGRW----ELLGLLPLF------DPPRPDSKATIARAKELGVRVKMITG 462
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  707 DNINTARAIAAKCGI---IQPGEDFLCLEGKefnrriRNEKGEIEQERLDKVwpklRVLARSSPTDKHTLVKGIidsttg 783
Cdd:cd02076  463 DQLAIAKETARQLGMgtnILSAERLKLGGGG------GGMPGSELIEFIEDA----DGFAEVFPEHKYRIVEAL------ 526
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  784 EQR-QVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVnVV 862
Cdd:cd02076  527 QQRgHLVGMTGDGVNDAPALKKADVGIAVSGA-TDAARAAADIVLTAPGLSVIIDAIKTSRQIFQRMKSYVIYRIAE-TL 604
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  863 AVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEppteslllRKPYgRDKPLISRtmMKNILGHAVYqLAIIFT 942
Cdd:cd02076  605 RILVFFTLGILILNFYPLPLIMIVLIAILNDGATLTIAYD--------NVPP-SPRPVRWN--MPELLGIATV-LGVVLT 672
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  943 LLFVGELFFDIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDG-IFSNPIFCTIVLGTFgiqivIV 1021
Cdd:cd02076  673 ISSFLLLWLLDDQGWFEDIVLSAGELQTILYLQLSISGHLTIFVTRTRGPFWRPRPSpLLFIAVVLTQILATL-----LA 747
                        970       980       990
                 ....*....|....*....|....*....|
gi 48255953 1022 QFGgkPFSCSPLSteqWLWCLFVGVGELVW 1051
Cdd:cd02076  748 VYG--WFMFAGIG---WGWALLVWIYALVW 772
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
194-908 2.80e-64

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 231.40  E-value: 2.80e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  194 KFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLKIDESSLTGESDHVRKSADKDpmLLSGTHVMEGSGR 273
Cdd:cd02609   93 KVTVIRDGQEVKIPPEELVLDDILILKPGEQIPADGEVVEGGGLEVDESLLTGESDLIPKKAGDK--LLSGSFVVSGAAY 170
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  274 MVVTAVGvnsqtgiiftllgaggeeeekkdkkgkqqdgamesSQTKAKKqdgavamemqplksaeggeMEEREKKKanap 353
Cdd:cd02609  171 ARVTAVG-----------------------------------AESYAAK-------------------LTLEAKKH---- 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  354 KKEKSVLQGKLTKLAVqigkaglVMSAITVIILVLYFViETFVVEGRTWLAEctpvyvqyfvkffIIG-VTVLVVAVPEG 432
Cdd:cd02609  193 KLINSELLNSINKILK-------FTSFIIIPLGLLLFV-EALFRRGGGWRQA-------------VVStVAALLGMIPEG 251
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  433 LPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIpapsalTPKILDLL 512
Cdd:cd02609  252 LVLLTSVALAVGAIRLAKKKVLVQELYSIETLARVDVLCLDKTGTITEGKMKVERVEPLDEANEAE------AAAALAAF 325
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  513 VHAISINsayttkilppekegalprqvgNKTECALLGFVLDLKRdfQPVREQIPedklykvytFNSVRKSMStvIRMPDG 592
Cdd:cd02609  326 VAASEDN---------------------NATMQAIRAAFFGNNR--FEVTSIIP---------FSSARKWSA--VEFRDG 371
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  593 GfrLFSKGASEILLkkctnilnsngelrgfrpRDRDDMVRKIIEPMACDGLRTICIAYrdfsAGQEPDWDnenEVVGDLT 672
Cdd:cd02609  372 G--TWVLGAPEVLL------------------GDLPSEVLSRVNELAAQGYRVLLLAR----SAGALTHE---QLPVGLE 424
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  673 CIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGiiqpgedflcLEGKEFNRRIRNEKGEieqERL 752
Cdd:cd02609  425 PLALILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAIAKRAG----------LEGAESYIDASTLTTD---EEL 491
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  753 DKVWPKLRVLARSSPTDKHTLVKgiidsTTGEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNF 832
Cdd:cd02609  492 AEAVENYTVFGRVTPEQKRQLVQ-----ALQALGHTVAMTGDGVNDVLALKEADCSIAMA-SGSDATRQVAQVVLLDSDF 565
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 48255953  833 TSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESL 908
Cdd:cd02609  566 SALPDVVFEGRRVVNNIERVASLFLVKTIYSVLLALICVITALPFPFLPIQITLISLFTIGIPSFFLALEPNKRRI 641
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
196-870 4.61e-55

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 205.38  E-value: 4.61e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  196 TVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLI--QANdlkIDESSLTGESDHVRKSADkDPmLLSGTHVMEGSGR 273
Cdd:COG2217  216 RVLRDGEEVEVPVEELRVGDRVLVRPGERIPVDGVVLegESS---VDESMLTGESLPVEKTPG-DE-VFAGTINLDGSLR 290
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  274 MVVTAVGVNSQ-TGIIftllgaggeeeekkdkkgkqqdgamessqtkakkqdgavamEMqplksaeggeMEEREKKKAna 352
Cdd:COG2217  291 VRVTKVGSDTTlARII-----------------------------------------RL----------VEEAQSSKA-- 317
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  353 pkkeksvlqgKLTKLAVQIgkaglvmSAI-TVIILVLYFVieTFVVegrtWLaectpVYVQYFVKFFIIGVTVLVVAVPE 431
Cdd:COG2217  318 ----------PIQRLADRI-------ARYfVPAVLAIAAL--TFLV----WL-----LFGGDFSTALYRAVAVLVIACPC 369
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  432 GLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSylgdthykeIPAPSALTPKILDL 511
Cdd:COG2217  370 ALGLATPTAIMVGTGRAARRGILIKGGEALERLAKVDTVVFDKTGTLTEGKPEVTDV---------VPLDGLDEDELLAL 440
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  512 LV-------HAIS--INSAYttkilppEKEGALPRQVGNKTECALLGfvldlkrdfqpVREQIpEDKLYKVytfnsvrks 582
Cdd:COG2217  441 AAaleqgseHPLAraIVAAA-------KERGLELPEVEDFEAIPGKG-----------VEATV-DGKRVLV--------- 492
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  583 mstvirmpdGGFRLFSKGASEIllkkctnilnsngelrgfrprdrDDMVRKIIEPMACDGLRTICIAyrdfsagqepdWD 662
Cdd:COG2217  493 ---------GSPRLLEEEGIDL-----------------------PEALEERAEELEAEGKTVVYVA-----------VD 529
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  663 NEnevvgdltCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIqpgedflclegkefnrrirn 742
Cdd:COG2217  530 GR--------LLGLIALADTLRPEAAEAIAALKALGIRVVMLTGDNERTAEAVARELGID-------------------- 581
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  743 ekgeieqerldkvwpklRVLARSSPTDKHTLVKGIIdsttgEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEA 822
Cdd:COG2217  582 -----------------EVRAEVLPEDKAAAVRELQ-----AQGKKVAMVGDGINDAPALAAADVGIAMG-SGTDVAIEA 638
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*...
gi 48255953  823 SDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 870
Cdd:COG2217  639 ADIVLMRDDLRGVPDAIRLSRATMRIIRQNLFWAFGYNVIGIPLAAGG 686
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
55-867 1.55e-51

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 196.83  E-value: 1.55e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    55 DVSGLCRRLKTSPtEGLadNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSlglsfYAppgees 134
Cdd:PRK10517   53 PEEELWKTFDTHP-EGL--NEAEVESAREQHGENELPAQKPLPWWVHLWVCYRNPFNILLTILGAIS-----YA------ 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   135 eacgnvsggAEDEGeaeagwiegAAILLSVIcVVLVTAFNDWSKEKQFRG---LQSRIEQeqKFTVIRNG------QLLQ 205
Cdd:PRK10517  119 ---------TEDLF---------AAGVIALM-VAISTLLNFIQEARSTKAadaLKAMVSN--TATVLRVIndkgenGWLE 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   206 VPVAALVVGDIAQVKYGDLLPADGVLIQANDLKIDESSLTGESDHVRKSA-----------DKDPMLLSGTHVMEGSGRM 274
Cdd:PRK10517  178 IPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKFAttrqpehsnplECDTLCFMGTNVVSGTAQA 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   275 VVTAVGVNSQTGiifTLLGaggeeeekkdkkgkqQDGAMESSQTKAKKQDGAVAMemqplksaeggemeerekkkanapk 354
Cdd:PRK10517  258 VVIATGANTWFG---QLAG---------------RVSEQDSEPNAFQQGISRVSW------------------------- 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   355 keksvlqgKLTKLAvqigkagLVMSAItviilVLYfvIETFVvEGRTWLAectpvyvqyfvkfFIIGVTVLVVAVPEGLP 434
Cdd:PRK10517  295 --------LLIRFM-------LVMAPV-----VLL--INGYT-KGDWWEA-------------ALFALSVAVGLTPEMLP 338
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   435 LAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQsylgdtHYKEIPAPSaltpkilDLLVH 514
Cdd:PRK10517  339 MIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKIVLEN------HTDISGKTS-------ERVLH 405
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   515 AISINSAYTTKIlppekEGALPRQVgnkTECALLGFVLDLKRDFQPVREqIPedklykvytFNSVRKSMSTVIRMPDGGF 594
Cdd:PRK10517  406 SAWLNSHYQTGL-----KNLLDTAV---LEGVDEESARSLASRWQKIDE-IP---------FDFERRRMSVVVAENTEHH 467
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   595 RLFSKGASEILLKKCTNILNsNGELRGFRPrDRDDMVRKIIEPMACDGLRTICIAYRDFSAGQEpDWDNENEvvGDLTCI 674
Cdd:PRK10517  468 QLICKGALEEILNVCSQVRH-NGEIVPLDD-IMLRRIKRVTDTLNRQGLRVVAVATKYLPAREG-DYQRADE--SDLILE 542
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   675 AVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNintaRAIAAKcgiiqpgedfLCLE-GKEFNRRIRNekGEIEQ---E 750
Cdd:PRK10517  543 GYIAFLDPPKETTAPALKALKASGVTVKILTGDS----ELVAAK----------VCHEvGLDAGEVLIG--SDIETlsdD 606
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   751 RLDKVWPKLRVLARSSPTDKHTLVKGIIDsttgeQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDD 830
Cdd:PRK10517  607 ELANLAERTTLFARLTPMHKERIVTLLKR-----EGHVVGFMGDGINDAPALRAADIGISVD-GAVDIAREAADIILLEK 680
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|..
gi 48255953   831 NFTSIVKAVMWGRNVYDSISKFLqfQLTV-----NVVAVIVA 867
Cdd:PRK10517  681 SLMVLEEGVIEGRRTFANMLKYI--KMTAssnfgNVFSVLVA 720
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
877-1055 7.21e-51

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 177.05  E-value: 7.21e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    877 SPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVYQLAIIFTLLFVGELFFDIDSG 956
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISES 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    957 RNAplhsppsehYTIIFNTFVMMQLFNEINARKIHGERNVFdGIFSNPIFCTIVLGTFGIQIVIVQ--FGGKPFSCSPLS 1034
Cdd:pfam00689   82 QNA---------QTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYvpPLQAVFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 48255953   1035 TEQWLWCLFVGVGELVWGQVI 1055
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
175-870 3.64e-49

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 184.37  E-value: 3.64e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    175 DWSKEKQFRGLQSRIEQ--EQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLkIDESSLTGESDHVR 252
Cdd:TIGR01525   36 ERAKSRASDALSALLALapSTARVLQGDGSEEEVPVEELQVGDIVIVRPGERIPVDGVVISGESE-VDESALTGESMPVE 114
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    253 KSADKDpmLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLlgaggeeeekkdkkgkqqdgaMESSQTkakkqdgavamemq 332
Cdd:TIGR01525  115 KKEGDE--VFAGTINGDGSLTIRVTKLGEDSTLAQIVEL---------------------VEEAQS-------------- 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    333 plksaeggemeerekkkanapkkEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFVvegrtwlaectpvyvq 412
Cdd:TIGR01525  158 -----------------------SKAPIQRLADRIASYYVPAVLAIALLTFVVWLALGALWREA---------------- 198
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    413 yfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQ-SYLG 491
Cdd:TIGR01525  199 -----LYRALTVLVVACPCALGLATPVAILVAIGAAARRGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTVVDiEPLD 273
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    492 DTHYKEIPAPSALTPKILDllvHAISInsayttkilppekegALPRQVgNKTECALLGfvldlkRDFQPVreqipedkly 571
Cdd:TIGR01525  274 DASEEELLALAAALEQSSS---HPLAR---------------AIVRYA-KERGLELPP------EDVEEV---------- 318
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    572 kvytfnsvrksmstvirmPDGGFRLFSKGASEILLKKCTNILNSngELRGFRPRDRDDMVRKIIEpmacdGLRTICIAYR 651
Cdd:TIGR01525  319 ------------------PGKGVEATVDGGREVRIGNPRFLGNR--ELAIEPISASPDLLNEGES-----QGKTVVFVAV 373
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    652 DfsagqepdwdneNEVVGdltciaVVGIEDPVRPEVPEAIRKCQRAG-ITVRMVTGDNINTARAIAAKCGIiqpgedflc 730
Cdd:TIGR01525  374 D------------GELLG------VIALRDQLRPEAKEAIAALKRAGgIKLVMLTGDNRSAAEAVAAELGI--------- 426
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    731 legkefnrrirnekgeiEQErldkvwpklrVLARSSPTDKHTLVKGIIdsttgEQRQVVAVTGDGTNDGPALKKADVGFA 810
Cdd:TIGR01525  427 -----------------DDE----------VHAELLPEDKLAIVKKLQ-----EEGGPVAMVGDGINDAPALAAADVGIA 474
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    811 MGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 870
Cdd:TIGR01525  475 MG-SGSDVAIEAADIVLLNDDLRSLPTAIDLSRKTRRIIKQNLAWALGYNLVAIPLAAGG 533
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
196-839 3.30e-45

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 174.20  E-value: 3.30e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  196 TVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLkIDESSLTGESDHVRKSADkDPmLLSGTHVMEGSGRMV 275
Cdd:cd02094  142 RVIRDGKEVEVPIEEVQVGDIVRVRPGEKIPVDGVVVEGESS-VDESMLTGESLPVEKKPG-DK-VIGGTINGNGSLLVR 218
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  276 VTAVGVNSQTGIIFTLlgaggeeeekkdkkgkqqdgaMESSQT-KAKKQdgavamemqplksaeggemeerekkkanapk 354
Cdd:cd02094  219 ATRVGADTTLAQIIRL---------------------VEEAQGsKAPIQ------------------------------- 246
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  355 keksvlqgkltKLAVQIgkaglvmSAITV-IILVLyfVIETFVVegrtWLAECTPVYVQYFVKFFIigvTVLVVAVPEGL 433
Cdd:cd02094  247 -----------RLADRV-------SGVFVpVVIAI--AILTFLV----WLLLGPEPALTFALVAAV---AVLVIACPCAL 299
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  434 PLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqsylgdthyKEIPAPSALTPKILDLlV 513
Cdd:cd02094  300 GLATPTAIMVGTGRAAELGILIKGGEALERAHKVDTVVFDKTGTLTEGKPEVT---------DVVPLPGDDEDELLRL-A 369
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  514 HAISINSayttkilppekEGALPRQVgnKTECALLGFVLDLKRDFQPVreqipedklykvytfnsVRKSMSTVIrmpdGG 593
Cdd:cd02094  370 ASLEQGS-----------EHPLAKAI--VAAAKEKGLELPEVEDFEAI-----------------PGKGVRGTV----DG 415
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  594 FRLFSkGASEILLKKCTNILNSNGElrgfrprdrddmvrkiIEPMACDGLRTICIAYrdfsagqepdwdnENEVVGdltc 673
Cdd:cd02094  416 RRVLV-GNRRLMEENGIDLSALEAE----------------ALALEEEGKTVVLVAV-------------DGELAG---- 461
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  674 iaVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIiqpgedflclegkefnrrirnekgeieqerlD 753
Cdd:cd02094  462 --LIAVADPLKPDAAEAIEALKKMGIKVVMLTGDNRRTARAIAKELGI-------------------------------D 508
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  754 KVWpklrvlARSSPTDKHTLVKGIidsttGEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFT 833
Cdd:cd02094  509 EVI------AEVLPEDKAEKVKKL-----QAQGKKVAMVGDGINDAPALAQADVGIAIG-SGTDVAIESADIVLMRGDLR 576

                 ....*.
gi 48255953  834 SIVKAV 839
Cdd:cd02094  577 GVVTAI 582
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
175-870 1.01e-44

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 172.40  E-value: 1.01e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  175 DWSKEKQFRGLQSRIEQEQKF-TVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLkIDESSLTGESDHVRK 253
Cdd:cd02079  106 ERARSRARSALKALLSLAPETaTVLEDGSTEEVPVDDLKVGDVVLVKPGERIPVDGVVVSGESS-VDESSLTGESLPVEK 184
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  254 SADkDPmLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLlgaggeeeekkdkkgkqqdgaMESSQtkakkqdgavamemqp 333
Cdd:cd02079  185 GAG-DT-VFAGTINLNGPLTIEVTKTGEDTTLAKIIRL---------------------VEEAQ---------------- 225
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  334 lksaeggemeerekkkanapkKEKSVLQGKLTKLAVQIGKAGLVMSAITVIIlvlyfvietfvvegrtwlaecTPVYVQY 413
Cdd:cd02079  226 ---------------------SSKPPLQRLADRFARYFTPAVLVLAALVFLF---------------------WPLVGGP 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  414 FVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTV--VQSYLG 491
Cdd:cd02079  264 PSLALYRALAVLVVACPCALGLATPTAIVAGIGRAARKGILIKGGDVLETLAKVDTVAFDKTGTLTEGKPEVteIEPLEG 343
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  492 DTHYKEIPAPSAL---TPKILdllvhAISINSAYTTKILPPEKEGALprqvgnktecallgfvldlkrdfqpvrEQIPed 568
Cdd:cd02079  344 FSEDELLALAAALeqhSEHPL-----ARAIVEAAEEKGLPPLEVEDV---------------------------EEIP-- 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  569 klykvytfnsvrksmstvirmpdgGFRLFSKGASEILLkkctniLNSNGELRGFRPRDRDDMVRKIiepmacdGLRTICI 648
Cdd:cd02079  390 ------------------------GKGISGEVDGREVL------IGSLSFAEEEGLVEAADALSDA-------GKTSAVY 432
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  649 AYRDfsagqepdwdneNEVVGdltciaVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIiqpgedf 728
Cdd:cd02079  433 VGRD------------GKLVG------LFALEDQLRPEAKEVIAELKSGGIKVVMLTGDNEAAAQAVAKELGI------- 487
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  729 lclegkefnrrirnekgeieqerldkvwpkLRVLARSSPTDKHTLVKGIidsttGEQRQVVAVTGDGTNDGPALKKADVG 808
Cdd:cd02079  488 ------------------------------DEVHAGLLPEDKLAIVKAL-----QAEGGPVAMVGDGINDAPALAQADVG 532
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 48255953  809 FAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 870
Cdd:cd02079  533 IAMG-SGTDVAIETADIVLLSNDLSKLPDAIRLARRTRRIIKQNLAWALGYNAIALPLAALG 593
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
154-870 1.17e-42

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 164.80  E-value: 1.17e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    154 WIEGAAILLSVIcvvLVTAFNDWSKEKQFRGLQSRIEQE-QKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLI 232
Cdd:TIGR01512   18 YLEGALLLLLFS---IGETLEEYASGRARRALKALMELApDTARRLQGDSLEEVAVEELKVGDVVVVKPGERVPVDGEVL 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    233 QANDLkIDESSLTGESDHVRKSADKDpmLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLlgaggeeeekkdkkgkqqdga 312
Cdd:TIGR01512   95 SGTSS-VDESALTGESVPVEKAPGDE--VFAGAINLDGVLTIEVTKLPADSTIAKIVNL--------------------- 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    313 messqtkakkqdgavamemqplksaeggeMEEREKKKAnapkkeksvlqgKLTKLAVQIGK--AGLVMSAITVIILVLYF 390
Cdd:TIGR01512  151 -----------------------------VEEAQSRKA------------PTQRFIDRFARyyTPAVLAIALAAALVPPL 189
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    391 VietfvvegRTWLaectpvyvqyFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAI 470
Cdd:TIGR01512  190 L--------GAGP----------FLEWIYRALVLLVVASPCALVISAPAAYLSAISAAARHGILIKGGAALEALAKIKTV 251
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    471 CSDKTGTLTTNRMTVVQSYLGDTH-----YKEIPAPSALTPKILdllvhAISINSAYTTKILPPEKEgalprqvgnktec 545
Cdd:TIGR01512  252 AFDKTGTLTTGKPKVTDVHPADGHsesevLRLAAAAEQGSTHPL-----ARAIVDYARARELAPPVE------------- 313
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    546 allgfvldlkrDFQPVreqipedklykvytfnsvrksmstvirmPDGGFRLFSKGaseillkkctnilnsnGELRGFRPR 625
Cdd:TIGR01512  314 -----------DVEEV----------------------------PGEGVRAVVDG----------------GEVRIGNPR 338
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    626 DRDDMVRKIIEPMaCDGLRTICIAYRDfsagqepdwdnenevvGDLtcIAVVGIEDPVRPEVPEAIRKCQRAGI-TVRMV 704
Cdd:TIGR01512  339 SLSEAVGASIAVP-ESAGKTIVLVARD----------------GTL--LGYIALSDELRPDAAEAIAELKALGIkRLVML 399
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    705 TGDNINTARAIAAKCGIIQpgedflclegkefnrrirnekgeieqerldkvwpklrVLARSSPTDKHTLVKGIIdsttgE 784
Cdd:TIGR01512  400 TGDRRAVAEAVARELGIDE-------------------------------------VHAELLPEDKLEIVKELR-----E 437
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    785 QRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAV 864
Cdd:TIGR01512  438 KAGPVAMVGDGINDAPALAAADVGIAMGASGSDVALETADVVLLNDDLSRLPQAIRLARRTRRIIKQNVVIALGIILVLI 517

                   ....*.
gi 48255953    865 IVAFTG 870
Cdd:TIGR01512  518 LLALFG 523
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
161-941 2.88e-41

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 164.27  E-value: 2.88e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  161 LLSVICVVLVTA----FNDWSKEKQFRGLQSRieqeqKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQAND 236
Cdd:cd02073   52 LLPLLFVLGVTAikegYEDIRRHKSDNEVNNR-----PVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLLSSSE 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  237 LK----IDESSLTGESDH-VRKSADKDPMLLSGTHVMEGSGRMVVtavgvnsqtgiiftllgaggeeeekkdkkgkqqdg 311
Cdd:cd02073  127 PDglcyVETANLDGETNLkIRQALPETALLLSEEDLARFSGEIEC----------------------------------- 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  312 amESSQTKAKKQDGAvaMEMQPLK----SAEggEMEEREKKKANAPKKEKSVL-QGKLTKLAVQIGKAGLVMSAIT---- 382
Cdd:cd02073  172 --EQPNNDLYTFNGT--LELNGGRelplSPD--NLLLRGCTLRNTEWVYGVVVyTGHETKLMLNSGGTPLKRSSIEkkmn 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  383 --VIILVLYFVIETFV--VEGRTWLAECTP------------VYVQYFVKF--FIIgvtVLVVAVPegLPLAVTISLAYS 444
Cdd:cd02073  246 rfIIAIFCILIVMCLIsaIGKGIWLSKHGRdlwyllpkeersPALEFFFDFltFII---LYNNLIP--ISLYVTIEVVKF 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  445 V--------KKMMKDNN----LVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIPAPSaltpkildlL 512
Cdd:cd02073  321 LqsffinwdLDMYDEETdtpaEARTSNLNEELGQVEYIFSDKTGTLTENIMEFKKCSINGVDYGFFLALA---------L 391
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  513 VHAISINSAYTTKILP-----PEkEGALPRQvgnkteCALLGFVLdLKRDFQPV-REQIPEDKLYK---VYTFNSVRKSM 583
Cdd:cd02073  392 CHTVVPEKDDHPGQLVyqassPD-EAALVEA------ARDLGFVF-LSRTPDTVtINALGEEEEYEilhILEFNSDRKRM 463
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  584 STVIRMPDGGFRLFSKGASEILLKKCTNilnSNGELRgfrprdrdDMVRKIIEPMACDGLRTICIAYRDFSAGQEPDWDN 663
Cdd:cd02073  464 SVIVRDPDGRILLYCKGADSVIFERLSP---SSLELV--------EKTQEHLEDFASEGLRTLCLAYREISEEEYEEWNE 532
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  664 E-------------------NEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQP 724
Cdd:cd02073  533 KydeastalqnreelldevaEEIEKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDKQETAINIGYSCRLLSE 612
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  725 G-EDF-LCLEGKEFNrrirnekgEIEQERLDKVWPKLRVLA------RSSPTDKHTLVKGIIDSTTGeqrqVVAVTGDGT 796
Cdd:cd02073  613 DmENLaLVIDGKTLT--------YALDPELERLFLELALKCkaviccRVSPLQKALVVKLVKKSKKA----VTLAIGDGA 680
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  797 NDGPALKKADVGfaMGIAGtdvaKE------ASDIILTddNFTSIVKAVM-WGRNVYDSISKFLQFQLTVNVVAVIV--- 866
Cdd:cd02073  681 NDVSMIQEAHVG--VGISG----QEgmqaarASDYAIA--QFRFLRRLLLvHGRWSYQRLAKLILYFFYKNIAFYLTqfw 752
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  867 --AFTGAciTQDSPLKAVQMLWVNLImdtFASLalatePP----------TESLLLRKP--YgrdKPLISRTM--MKNIL 930
Cdd:cd02073  753 yqFFNGF--SGQTLYDSWYLTLYNVL---FTSL-----PPlvigifdqdvSAETLLRYPelY---KPGQLNELfnWKVFL 819
                        890
                 ....*....|....
gi 48255953  931 G---HAVYQLAIIF 941
Cdd:cd02073  820 YwilDGIYQSLIIF 833
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
200-867 7.97e-38

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 150.50  E-value: 7.97e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    200 NGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDlKIDESSLTGESDHVRKSADkDPmLLSGTHVMEGSGRMVVTAV 279
Cdd:TIGR01511   99 DGSIEEVPVALLQPGDIVKVLPGEKIPVDGTVIEGES-EVDESLVTGESLPVPKKVG-DP-VIAGTVNGTGSLVVRATAT 175
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    280 GVNSQTGIIFTLLGaggeeeekkdkkgkqqdgamESSQTKAKKQDgavamemqplksaeggemeerekkkanapkkeksv 359
Cdd:TIGR01511  176 GEDTTLAQIVRLVR--------------------QAQQSKAPIQR----------------------------------- 200
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    360 LQGKLTKLavqigkagLVMSAITVIILvlyfvieTFVVegrtWLAEctpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVTI 439
Cdd:TIGR01511  201 LADKVAGY--------FVPVVIAIALI-------TFVI----WLFA------------LEFAVTVLIIACPCALGLATPT 249
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    440 SLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQ-SYLGDTHYKEIPA-PSALTPKILDLLVHAIs 517
Cdd:TIGR01511  250 VIAVATGLAAKNGVLIKDGDALERAANIDTVVFDKTGTLTQGKPTVTDvHVFGDRDRTELLAlAAALEAGSEHPLAKAI- 328
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    518 INSAyttkilppEKEGALPRQVGNKTECALLGfvldLKRDFQPVREQIPEDKLYKVYT--FNSVRKSMSTVIrmpdggfr 595
Cdd:TIGR01511  329 VSYA--------KEKGITLVTVSDFKAIPGIG----VEGTVEGTKIQLGNEKLLGENAikIDGKAGQGSTVV-------- 388
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    596 lfskgaseillkkctnILNSNGELRGfrprdrddmvrkiiepmacdglrticiayrdfsagqepdwdnenevvgdltcia 675
Cdd:TIGR01511  389 ----------------LVAVNGELAG------------------------------------------------------ 398
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    676 VVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIiqpgedflclegkefnrrirnekgeieqerldkv 755
Cdd:TIGR01511  399 VFALEDQLRPEAKEVIQALKRRGIEPVMLTGDNRKTAKAVAKELGI---------------------------------- 444
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    756 wpklRVLARSSPTDKHTLVKGIIdsttgEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSI 835
Cdd:TIGR01511  445 ----DVRAEVLPDDKAALIKKLQ-----EKGPVVAMVGDGINDAPALAQADVGIAIG-AGTDVAIEAADVVLLRNDLNDV 514
                          650       660       670
                   ....*....|....*....|....*....|..
gi 48255953    836 VKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA 867
Cdd:TIGR01511  515 ATAIDLSRKTLRRIKQNLLWAFGYNVIAIPIA 546
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
196-926 5.77e-37

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 150.95  E-value: 5.77e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   196 TVIR------NGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLKIDESSLTGES---------DHVR-KSADKDP 259
Cdd:PRK15122  151 TVLRrghagaEPVRREIPMRELVPGDIVHLSAGDMIPADVRLIESRDLFISQAVLTGEAlpvekydtlGAVAgKSADALA 230
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   260 -----------MLLSGTHVMEGSGRMVVTAVGvnsqtgiiftllgaggeeeekkdkkgkqqdgamessqtkAKKQDGAVA 328
Cdd:PRK15122  231 ddegslldlpnICFMGTNVVSGTATAVVVATG---------------------------------------SRTYFGSLA 271
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   329 memqplksaeggemeerekkkanapkkeKSVLqGKLTKLAVQIGkaglVMSaitVIILVLYFVIetfvvegrtwlaectp 408
Cdd:PRK15122  272 ----------------------------KSIV-GTRAQTAFDRG----VNS---VSWLLIRFML---------------- 299
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   409 vyVQYFVKFFIIGVT----------VLVVAV---PEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKT 475
Cdd:PRK15122  300 --VMVPVVLLINGFTkgdwleallfALAVAVgltPEMLPMIVSSNLAKGAIAMARRKVVVKRLNAIQNFGAMDVLCTDKT 377
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   476 GTLTTNRMTVVQSYlgDTHYKEipapsalTPKILDLlvhaISINSAYttkilppekegalprQVG--NKTECALLGFVlD 553
Cdd:PRK15122  378 GTLTQDRIILEHHL--DVSGRK-------DERVLQL----AWLNSFH---------------QSGmkNLMDQAVVAFA-E 428
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   554 LKRDFQPVREQIPEDKLykvyTFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNILNsNGELRGFRPRDRDDMVRK 633
Cdd:PRK15122  429 GNPEIVKPAGYRKVDEL----PFDFVRRRLSVVVEDAQGQHLLICKGAVEEMLAVATHVRD-GDTVRPLDEARRERLLAL 503
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   634 IIEPMAcDGLRTICIAYRDFSAGQEPDW---DNENEVV--GDLTCIavvgieDPVRPEVPEAIRKCQRAGITVRMVTGDN 708
Cdd:PRK15122  504 AEAYNA-DGFRVLLVATREIPGGESRAQystADERDLVirGFLTFL------DPPKESAAPAIAALRENGVAVKVLTGDN 576
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   709 -INTARaIAAKCGIiQPGEDflcLEGKEFNRrirnekgeIEQERLDKVWPKLRVLARSSPTDKHTLVKGIidSTTGeqrQ 787
Cdd:PRK15122  577 pIVTAK-ICREVGL-EPGEP---LLGTEIEA--------MDDAALAREVEERTVFAKLTPLQKSRVLKAL--QANG---H 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   788 VVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLqfQLTV-----NVV 862
Cdd:PRK15122  639 TVGFLGDGINDAPALRDADVGISVD-SGADIAKESADIILLEKSLMVLEEGVIKGRETFGNIIKYL--NMTAssnfgNVF 715
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 48255953   863 AVIVAftGACITQdSPLKAVQMLWVNLIMDtFASLALatepPTESL---LLRKPYGRDKPLISRTMM 926
Cdd:PRK15122  716 SVLVA--SAFIPF-LPMLAIHLLLQNLMYD-ISQLSL----PWDKMdkeFLRKPRKWDAKNIGRFML 774
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
167-868 1.51e-34

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 143.68  E-value: 1.51e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    167 VVLVT----AFNDWSkekqfRGLQSRIEQEQKFTVIRN-GQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLK--- 238
Cdd:TIGR01652   60 VLIVTaikeAIEDIR-----RRRRDKEVNNRLTEVLEGhGQFVEIPWKDLRVGDIVKVKKDERIPADLLLLSSSEPDgvc 134
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    239 -IDESSLTGESD-HVRKSADKDPMLLSGTHVMEGSGRmvVTAVGVNSQtgiIFTLLGaggeeeekKDKKGKQQDGAMESS 316
Cdd:TIGR01652  135 yVETANLDGETNlKLRQALEETQKMLDEDDIKNFSGE--IECEQPNAS---LYSFQG--------NMTINGDRQYPLSPD 201
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    317 Q-----TKAKKQDGAVAMEMqplksAEGGEMeeREKKKANAPKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLY-- 389
Cdd:TIGR01652  202 NillrgCTLRNTDWVIGVVV-----YTGHDT--KLMRNATQAPSKRSRLEKELNFLIIILFCLLFVLCLISSVGAGIWnd 274
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    390 ------FVIEtFVVEGRTWLAEctpvyvqYFVKFFIIgVTVLVVAVPegLPLAVTISLAYSVKKMMKDNNL--------- 454
Cdd:TIGR01652  275 ahgkdlWYIR-LDVSERNAAAN-------GFFSFLTF-LILFSSLIP--ISLYVSLELVKSVQAYFINSDLqmyhektdt 343
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    455 ---VRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIP--------------------------APSALT 505
Cdd:TIGR01652  344 pasVRTSNLNEELGQVEYIFSDKTGTLTQNIMEFKKCSIAGVSYGDGFteikdgirerlgsyvenensmlveskGFTFVD 423
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    506 PKILDLL----VHAISINSAYTT-----KILP---PEKEGALPRQVGNKTECAL------LGFVLdLKRDFQPVREQIP- 566
Cdd:TIGR01652  424 PRLVDLLktnkPNAKRINEFFLAlalchTVVPefnDDGPEEITYQAASPDEAALvkaardVGFVF-FERTPKSISLLIEm 502
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    567 --EDKLYK---VYTFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKkctnILNSNGelrgfrpRDRDDMVRKIIEPMACD 641
Cdd:TIGR01652  503 hgETKEYEilnVLEFNSDRKRMSVIVRNPDGRIKLLCKGADTVIFK----RLSSGG-------NQVNEETKEHLENYASE 571
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    642 GLRTICIAYRDFSAGQEPDW-----------DNENEVVG--------DLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVR 702
Cdd:TIGR01652  572 GLRTLCIAYRELSEEEYEEWneeyneastalTDREEKLDvvaesiekDLILLGATAIEDKLQEGVPETIELLRQAGIKIW 651
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    703 MVTGDNINTARAIAAKCGIIQPGEDFL---------CLEGKEFNRRIRNEKGEIEQERLDK---------------VWPK 758
Cdd:TIGR01652  652 VLTGDKVETAINIGYSCRLLSRNMEQIvitsdsldaTRSVEAAIKFGLEGTSEEFNNLGDSgnvalvidgkslgyaLDEE 731
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    759 LR------------VLA-RSSPTDKHTLVKGIIDSTtgeQRQVVAVtGDGTNDGPALKKADVGfaMGIAGTD--VAKEAS 823
Cdd:TIGR01652  732 LEkeflqlalkckaVICcRVSPSQKADVVRLVKKST---GKTTLAI-GDGANDVSMIQEADVG--VGISGKEgmQAVMAS 805
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*.
gi 48255953    824 DIILTddNFTSIVKAVMW-GRNVYDSISKFLQFQLTVNVVAVIVAF 868
Cdd:TIGR01652  806 DFAIG--QFRFLTKLLLVhGRWSYKRISKMILYFFYKNLIFAIIQF 849
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
69-947 3.68e-34

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 142.50  E-value: 3.68e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953     69 EGLAdnTNDLEKRRQIYGQNFIPPKQPkTFLQLVW-EALQdvTLIILEVAAIVSLGLSFYappgeeseacgnvsggaede 147
Cdd:TIGR01657  138 NGLT--TGDIAQRKAKYGKNEIEIPVP-SFLELLKeEVLH--PFYVFQVFSVILWLLDEY-------------------- 192
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    148 geaeagWIEGAAILL-SVICVVLVTafndWSKEKQFRGLQSRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKY--GDL 224
Cdd:TIGR01657  193 ------YYYSLCIVFmSSTSISLSV----YQIRKQMQRLRDMVHKPQSVIVIRNGKWVTIASDELVPGDIVSIPRpeEKT 262
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    225 LPADGVLIqANDLKIDESSLTGESDHVRKSADKDpmllsgthvmEGSGRMVVTAVGVNSqtgiIFTLLGAGGEEeekkdk 304
Cdd:TIGR01657  263 MPCDSVLL-SGSCIVNESMLTGESVPVLKFPIPD----------NGDDDEDLFLYETSK----KHVLFGGTKIL------ 321
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    305 kgkqqdgamessQTKA-KKQDGAVAMEMQP-LKSAEGGEMeerekkkanapkkeKSVLQGKL--TKLAVQIGKAGLVMSA 380
Cdd:TIGR01657  322 ------------QIRPyPGDTGCLAIVVRTgFSTSKGQLV--------------RSILYPKPrvFKFYKDSFKFILFLAV 375
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    381 ITVIILVlyFVIETFVVEGRTwlaectpvyvqyfVKFFIIGVT-VLVVAVPEGLPLAVTISLAYSVKKmmkdnnLVRHLD 459
Cdd:TIGR01657  376 LALIGFI--YTIIELIKDGRP-------------LGKIILRSLdIITIVVPPALPAELSIGINNSLAR------LKKKGI 434
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    460 AC---ETMGNATAI---CSDKTGTLTTNRMTV--VQSYLGD-THYKEIPAPSALTPKILdllVHAISINSAyTTKIlppe 530
Cdd:TIGR01657  435 FCtspFRINFAGKIdvcCFDKTGTLTEDGLDLrgVQGLSGNqEFLKIVTEDSSLKPSIT---HKALATCHS-LTKL---- 506
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    531 kEGALprqVGNKTECALLGFV-LDLKRD---------FQPVREQIPEDKLY--KVYTFNSVRKSMSTVIRMPDGGFR-LF 597
Cdd:TIGR01657  507 -EGKL---VGDPLDKKMFEATgWTLEEDdesaeptsiLAVVRTDDPPQELSiiRRFQFSSALQRMSVIVSTNDERSPdAF 582
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    598 SKGASEILLKKCtnilnSNGELrgfrPRDRDDMVRKIIEpmacDGLRTICIAYRD-----FSAGQEPDWDnenEVVGDLT 672
Cdd:TIGR01657  583 VKGAPETIQSLC-----SPETV----PSDYQEVLKSYTR----EGYRVLALAYKElpkltLQKAQDLSRD---AVESNLT 646
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    673 CIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQP---------------------------- 724
Cdd:TIGR01657  647 FLGFIVFENPLKPDTKEVIKELKRASIRTVMITGDNPLTAVHVARECGIVNPsntlilaeaeppesgkpnqikfevidsi 726
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    725 ------------------GEDF-----LCLEGKEFNRRIRNEKgeieqERLDKVWPKLRVLARSSPTDKHTLVKgiidsT 781
Cdd:TIGR01657  727 pfastqveipyplgqdsvEDLLasryhLAMSGKAFAVLQAHSP-----ELLLRLLSHTTVFARMAPDQKETLVE-----L 796
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    782 TGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAkeASdiiltddnFTSIVKAVmwgRNVYDSIskfLQFQLT-VN 860
Cdd:TIGR01657  797 LQKLDYTVGMCGDGANDCGALKQADVGISLSEAEASVA--AP--------FTSKLASI---SCVPNVI---REGRCAlVT 860
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    861 VVAVIVAFTGACITQ----------DSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRdkpLISRTMMKNIL 930
Cdd:TIGR01657  861 SFQMFKYMALYSLIQfysvsilyliGSNLGDGQFLTIDLLLIFPVALLMSRNKPLKKLSKERPPSN---LFSVYILTSVL 937
                          970
                   ....*....|....*..
gi 48255953    931 GhavyQLAIIFTLLFVG 947
Cdd:TIGR01657  938 I----QFVLHILSQVYL 950
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
197-867 2.37e-32

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 134.74  E-value: 2.37e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  197 VIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLkIDESSLTGESDHVRKSADKDpmLLSGTHVMEGSGRMVV 276
Cdd:cd07552  135 LVTDGSIEDVPVSELKVGDVVLVRAGEKIPADGTILEGESS-VNESMVTGESKPVEKKPGDE--VIGGSVNGNGTLEVKV 211
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  277 TAVGVNSQTGIIFTLLGaggeeeekkdkkgkqqdgamESSQTKAKKQDGA--VAmemqplksaeggemeerekkkanapk 354
Cdd:cd07552  212 TKTGEDSYLSQVMELVA--------------------QAQASKSRAENLAdkVA-------------------------- 245
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  355 keksvlqGKLTKLAVQIGkaglvmsAITVIIlvlyfvietfvvegrtWLaectpvYVQYFVKFFIIGVTVLVVAVPEGL- 433
Cdd:cd07552  246 -------GWLFYIALGVG-------IIAFII----------------WL------ILGDLAFALERAVTVLVIACPHALg 289
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  434 ---PLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEipapsaltpKILD 510
Cdd:cd07552  290 laiPLVVARSTSIAAKNGL----LIRNREALERARDIDVVLFDKTGTLTEGKFGVTDVITFDEYDED---------EILS 356
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  511 LLVhAISINSAYttkilppekegalPRQVGNKTECALLGFVLDLKRDFQPVR----EQIPEDKLYKVYTFNSVRKSmstv 586
Cdd:cd07552  357 LAA-ALEAGSEH-------------PLAQAIVSAAKEKGIRPVEVENFENIPgvgvEGTVNGKRYQVVSPKYLKEL---- 418
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  587 irmpdgGFRLfskgaSEILLKkctnilnsngelrgfRPRDRDDMVRKIIEpmacdglrticiayrdfsagqepdwdnENE 666
Cdd:cd07552  419 ------GLKY-----DEELVK---------------RLAQQGNTVSFLIQ---------------------------DGE 445
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  667 VVGdltciaVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIqpgedflclegkefnrrirnekge 746
Cdd:cd07552  446 VIG------AIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAEELGID------------------------ 495
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  747 ieqerldkvwpklRVLARSSPTDKHTLVKGIIDsttgeQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDII 826
Cdd:cd07552  496 -------------EYFAEVLPEDKAKKVKELQA-----EGKKVAMVGDGVNDAPALAQADVGIAIG-AGTDVAIESADVV 556
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|.
gi 48255953  827 LTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA 867
Cdd:cd07552  557 LVKSDPRDIVDFLELAKATYRKMKQNLWWGAGYNVIAIPLA 597
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
77-946 9.58e-32

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 133.91  E-value: 9.58e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   77 DLEKRRQIYGQNFIPPKQPKTFLQLVWEALQdvTLIILEVAAIVSLGLSFYAppgeeseacgnvsggaedegeaeagWIE 156
Cdd:cd07542    2 EQSDRRLIYGPNEIDVPLKSILKLLFKEVLN--PFYVFQLFSVILWSSDDYY-------------------------YYA 54
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  157 GAAILLSVICVVLVTafndWSKEKQFRGLQSRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKY-GDLLPADGVLIqAN 235
Cdd:cd07542   55 ACIVIISVISIFLSL----YETRKQSKRLREMVHFTCPVRVIRDGEWQTISSSELVPGDILVIPDnGTLLPCDAILL-SG 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  236 DLKIDESSLTGESDHVRKSA--DKDPMLLSGTHVMEGSGRMVVTavgvnSQTGIIftllgaggeeeekkdkkgkqqdgam 313
Cdd:cd07542  130 SCIVNESMLTGESVPVTKTPlpDESNDSLWSIYSIEDHSKHTLF-----CGTKVI------------------------- 179
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  314 essQTKAKKQDGAVAMEMQPLKSAEGGEMEerekkkanapkkeKSVLQGKLTK----------LAVQIGKAGLVMsAITV 383
Cdd:cd07542  180 ---QTRAYEGKPVLAVVVRTGFNTTKGQLV-------------RSILYPKPVDfkfyrdsmkfILFLAIIALIGF-IYTL 242
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  384 IILVLYFVietfvvegrtwlaectpvyvqYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKmmkdnnLVRHLDAC-- 461
Cdd:cd07542  243 IILILNGE---------------------SLGEIIIRALDIITIVVPPALPAALTVGIIYAQSR------LKKKGIFCis 295
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  462 -ETMGNATAI---CSDKTGTLTTNRMTV--VQSYLGDTHYKEIPAPSALTPKILDLLVHAISinSAYTTKILppekegal 535
Cdd:cd07542  296 pQRINICGKInlvCFDKTGTLTEDGLDLwgVRPVSGNNFGDLEVFSLDLDLDSSLPNGPLLR--AMATCHSL-------- 365
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  536 pRQVGNKtecaLLGFVLDLKRdFQPVREQIpedKLYKVYTFNSVRKSMSTVIRMP-DGGFRLFSKGASEILLKKC-TNIL 613
Cdd:cd07542  366 -TLIDGE----LVGDPLDLKM-FEFTGWSL---EILRQFPFSSALQRMSVIVKTPgDDSMMAFTKGAPEMIASLCkPETV 436
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  614 nsngelrgfrPRDRDDMVRKiiepMACDGLRTICIAYRDFsagQEPDWDNEN----EVVGDLTCIAVVGIEDPVRPEVPE 689
Cdd:cd07542  437 ----------PSNFQEVLNE----YTKQGFRVIALAYKAL---ESKTWLLQKlsreEVESDLEFLGLIVMENRLKPETAP 499
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  690 AIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEDFLCLEGKEfnrrirnEKGEIEQERLDKVWPKLRVLARSSPTD 769
Cdd:cd07542  500 VINELNRANIRTVMVTGDNLLTAISVARECGMISPSKKVILIEAVK-------PEDDDSASLTWTLLLKGTVFARMSPDQ 572
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  770 KHTLVKGI--IDSTtgeqrqvVAVTGDGTNDGPALKKADVGFAMGIAGTDVAkeASdiiltddnFTSIVKAVmwgRNVYD 847
Cdd:cd07542  573 KSELVEELqkLDYT-------VGMCGDGANDCGALKAADVGISLSEAEASVA--AP--------FTSKVPDI---SCVPT 632
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  848 SISK--------FLQFQLTvnVVAVIVAFTGACI--TQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRd 917
Cdd:cd07542  633 VIKEgraalvtsFSCFKYM--ALYSLIQFISVLIlySINSNLGDFQFLFIDLVIITPIAVFMSRTGAYPKLSSKRPPAS- 709
                        890       900
                 ....*....|....*....|....*....
gi 48255953  918 kpLISRTMMKNILGHAVYQLAIIFTLLFV 946
Cdd:cd07542  710 --LVSPPVLVSLLGQIVLILLFQVIGFLI 736
E1-E2_ATPase pfam00122
E1-E2 ATPase;
196-450 4.10e-31

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 120.75  E-value: 4.10e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    196 TVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLkIDESSLTGESDHVRKsaDKDPMLLSGTHVMEGSGRMV 275
Cdd:pfam00122    8 TVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSAS-VDESLLTGESLPVEK--KKGDMVYSGTVVVSGSAKAV 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    276 VTAVGVNSQTGIIFTLLgaggeeeekkdkkgkqqdgamessqtkakkqdgavamemqplksaeggemeerekkkaNAPKK 355
Cdd:pfam00122   85 VTATGEDTELGRIARLV----------------------------------------------------------EEAKS 106
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    356 EKSVLQGKLTKLAVQIGKAGLVMSAITVIILvlyfvietFVVEGRTWLAectpvyvqyfvkfFIIGVTVLVVAVPEGLPL 435
Cdd:pfam00122  107 KKTPLQRLLDRLGKYFSPVVLLIALAVFLLW--------LFVGGPPLRA-------------LLRALAVLVAACPCALPL 165
                          250
                   ....*....|....*
gi 48255953    436 AVTISLAYSVKKMMK 450
Cdd:pfam00122  166 ATPLALAVGARRLAK 180
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
199-870 9.44e-29

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 123.13  E-value: 9.44e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  199 RNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDlKIDESSLTGESDHVRKSADKDpmLLSGTHVMEGSGRMVVTA 278
Cdd:cd07551  119 RDGEIEEVPVEELQIGDRVQVRPGERVPADGVILSGSS-SIDEASITGESIPVEKTPGDE--VFAGTINGSGALTVRVTK 195
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  279 vgvnsqtgiiftllgaggeeeekkdkkgkqqdgamESSQTkakkqdgAVAMEMQPLKSAEGgemeerekkkanapkkEKS 358
Cdd:cd07551  196 -----------------------------------LSSDT-------VFAKIVQLVEEAQS----------------EKS 217
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  359 VLQGKLTKLavQIGKAGLVMSAITVIILVLYFVIetfvveGRTWLAEctpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVT 438
Cdd:cd07551  218 PTQSFIERF--ERIYVKGVLLAVLLLLLLPPFLL------GWTWADS------------FYRAMVFLVVASPCALVASTP 277
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  439 ISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYlgdthykeiPAPSALTPKILDLLVhAISI 518
Cdd:cd07551  278 PATLSAIANAARQGVLFKGGVHLENLGSVKAIAFDKTGTLTEGKPRVTDVI---------PAEGVDEEELLQVAA-AAES 347
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  519 NS------AYTTKILPPEKEGALPRQVGNKTECALLGFVldlkrdfqpvreqipedklykvytfnsvrksmstvirmpDG 592
Cdd:cd07551  348 QSehplaqAIVRYAEERGIPRLPAIEVEAVTGKGVTATV---------------------------------------DG 388
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  593 GFRLFSKGASeillkkctnilnsngelrgFRPRDRDDMVRKIIEPMACDGlRTICIAYRDfsagqepdwdnenEVVgdlt 672
Cdd:cd07551  389 QTYRIGKPGF-------------------FGEVGIPSEAAALAAELESEG-KTVVYVARD-------------DQV---- 431
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  673 cIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIiqpgedflclegkefnrrirnekgeieqerl 752
Cdd:cd07551  432 -VGLIALMDTPRPEAKEAIAALRLGGIKTIMLTGDNERTAEAVAKELGI------------------------------- 479
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  753 DKVWPKLRvlarssPTDKHTLVKgiidsttgEQRQ---VVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTD 829
Cdd:cd07551  480 DEVVANLL------PEDKVAIIR--------ELQQeygTVAMVGDGINDAPALANADVGIAMG-AGTDVALETADVVLMK 544
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|.
gi 48255953  830 DNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 870
Cdd:cd07551  545 DDLSKLPYAIRLSRKMRRIIKQNLIFALAVIALLIVANLFG 585
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
175-870 6.33e-28

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 120.46  E-value: 6.33e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  175 DWSKEKQFRGL-QSRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLkIDESSLTGESDHVRK 253
Cdd:cd07550   81 DYTARKSEKALlDLLSPQERTVWVERDGVEVEVPADEVQPGDTVVVGAGDVIPVDGTVLSGEAL-IDQASLTGESLPVEK 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  254 SADKdpMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLlgaggeeeekkdkkgkqqdgamessqtkakkqdgavamemqp 333
Cdd:cd07550  160 REGD--LVFASTVVEEGQLVIRAERVGRETRAARIAEL------------------------------------------ 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  334 lksaeggeMEEREKKKANApkkeksvlQGKLTKLAVQigkaglvmsaitviiLVLYfvieTFVVEGRTWLaectpvyvqy 413
Cdd:cd07550  196 --------IEQSPSLKARI--------QNYAERLADR---------------LVPP----TLGLAGLVYA---------- 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  414 FVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSylgdt 493
Cdd:cd07550  231 LTGDISRAAAVLLVDFSCGIRLSTPVAVLSALNHAARHGILVKGGRALELLAKVDTVVFDKTGTLTEGEPEVTAI----- 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  494 hykeIPAPSALTPKilDLLVHAISINSAYTtkiLPpekegaLPRQVGNKTEcallgfvldlkrdfqpvREQIPEDKLYKV 573
Cdd:cd07550  306 ----ITFDGRLSEE--DLLYLAASAEEHFP---HP------VARAIVREAE-----------------ERGIEHPEHEEV 353
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  574 YTFnsVRKSMSTVIrmpdggfrlfskGASEILLkkctnilnsnGELRGFRPRDRDDM--VRKIIEPMACDGLRTICIAYr 651
Cdd:cd07550  354 EYI--VGHGIASTV------------DGKRIRV----------GSRHFMEEEEIILIpeVDELIEDLHAEGKSLLYVAI- 408
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  652 dfsagqepdwdnENEVVGdltciaVVGIEDPVRPEVPEAIRKCQRAG-ITVRMVTGDNINTARAIAAKCGIiqpgedflc 730
Cdd:cd07550  409 ------------DGRLIG------VIGLSDPLRPEAAEVIARLRALGgKRIIMLTGDHEQRARALAEQLGI--------- 461
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  731 legkefnrrirnekgeieqerlDkvwpklRVLARSSPTDKHTLVKGIidsttgeQRQ--VVAVTGDGTNDGPALKKADVG 808
Cdd:cd07550  462 ----------------------D------RYHAEALPEDKAEIVEKL-------QAEgrTVAFVGDGINDSPALSYADVG 506
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 48255953  809 FAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 870
Cdd:cd07550  507 ISMR-GGTDIARETADVVLLEDDLRGLAEAIELARETMALIKRNIALVVGPNTAVLAGGVFG 567
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
154-897 4.44e-27

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 117.91  E-value: 4.44e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  154 WIEGAAIllsVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKF-TVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLI 232
Cdd:cd07545   59 WPEAAMV---VFLFAISEALEAYSMDRARRSIRSLMDIAPKTaLVRRDGQEREVPVAEVAVGDRMIVRPGERIAMDGIIV 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  233 QANDLkIDESSLTGESDHVRKSADKDpmLLSGThvMEGSGrmvvtavgvnsqtgiiftllgaggeeeekkdkkgkqqdgA 312
Cdd:cd07545  136 RGESS-VNQAAITGESLPVEKGVGDE--VFAGT--LNGEG---------------------------------------A 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  313 MESSQTKAKkQDGAVAMEMQPLKSAEGgemeerekkkanapkkEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVI 392
Cdd:cd07545  172 LEVRVTKPA-EDSTIARIIHLVEEAQA----------------ERAPTQAFVDRFARYYTPVVMAIAALVAIVPPLFFGG 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  393 ETFvvegrTWLAEctpvyvqyfvkffiiGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICS 472
Cdd:cd07545  235 AWF-----TWIYR---------------GLALLVVACPCALVISTPVSIVSAIGNAARKGVLIKGGVYLEELGRLKTVAF 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  473 DKTGTLTTNRMTVVQSY-LGDTHYKEIPA-PSALTPKILDLLVHAIsINSAyttkilppEKEGALPRQVGNKTecALLGf 550
Cdd:cd07545  295 DKTGTLTKGKPVVTDVVvLGGQTEKELLAiAAALEYRSEHPLASAI-VKKA--------EQRGLTLSAVEEFT--ALTG- 362
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  551 vldlkrdfQPVREQIPEDKLYKvytfnsvrksmstvirmpdGGFRLFS-KGASEIL-LKKCTNILNSNGElrgfrprdrd 628
Cdd:cd07545  363 --------RGVRGVVNGTTYYI-------------------GSPRLFEeLNLSESPaLEAKLDALQNQGK---------- 405
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  629 dmvrkiiEPMacdglrticiayrdfsagqepdwdneneVVGDLTCI-AVVGIEDPVRPEVPEAIRKCQRAGI--TVrMVT 705
Cdd:cd07545  406 -------TVM----------------------------ILGDGERIlGVIAVADQVRPSSRNAIAALHQLGIkqTV-MLT 449
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  706 GDNINTARAIAAKCGIiqpgedflclegkefnrrirnekGEIEQERLdkvwpklrvlarssPTDKHTLVKGIIdsttgEQ 785
Cdd:cd07545  450 GDNPQTAQAIAAQVGV-----------------------SDIRAELL--------------PQDKLDAIEALQ-----AE 487
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  786 RQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVI 865
Cdd:cd07545  488 GGRVAMVGDGVNDAPALAAADVGIAMGAAGTDTALETADIALMGDDLRKLPFAVRLSRKTLAIIKQNIAFALGIKLIALL 567
                        730       740       750
                 ....*....|....*....|....*....|..
gi 48255953  866 VAFTGacitqdsplkaVQMLWVNLIMDTFASL 897
Cdd:cd07545  568 LVIPG-----------WLTLWMAVFADMGASL 588
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
193-870 1.22e-24

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 110.10  E-value: 1.22e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  193 QKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLkIDESSLTGESDHVRKSADKDpmLLSGTHVMEGSG 272
Cdd:cd07544  110 RIAHRLVGGQLEEVPVEEVTVGDRLLVRPGEVVPVDGEVVSGTAT-LDESSLTGESKPVSKRPGDR--VMSGAVNGDSAL 186
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  273 RMVVTAVGVNSQTGIIFTLlgaggeeeekkdkkgkqqdgamessqtkakkqdgavamemqplksaeggeMEEREKKKAna 352
Cdd:cd07544  187 TMVATKLAADSQYAGIVRL--------------------------------------------------VKEAQANPA-- 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  353 pkkeksvlqgKLTKLAVQIGkaglvmsaitviilvLYFVIETFVVEGRTWLAECTPVYVqyfvkffiigVTVLVVAVPEG 432
Cdd:cd07544  215 ----------PFVRLADRYA---------------VPFTLLALAIAGVAWAVSGDPVRF----------AAVLVVATPCP 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  433 LPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQsylgdthykeipapsaltpkildll 512
Cdd:cd07544  260 LILAAPVAIVSGMSRSSRRGILVKDGGVLEKLARAKTVAFDKTGTLTYGQPKVVD------------------------- 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  513 VHAISinsayttkilppekegalprqvgNKTECALLGFVldlkrdfqpvreqipedklykvytfNSVRKSMSTVIRmpdg 592
Cdd:cd07544  315 VVPAP-----------------------GVDADEVLRLA-------------------------ASVEQYSSHVLA---- 342
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  593 gfRLFSKGASE--ILLKKCTNILNSNGE-LRGFrprdrddmvrkiiepmaCDGlRTICIAYRDF-SAGQEPDWDNENEVV 668
Cdd:cd07544  343 --RAIVAAAREreLQLSAVTELTEVPGAgVTGT-----------------VDG-HEVKVGKLKFvLARGAWAPDIRNRPL 402
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  669 GDLTC--------IAVVGIEDPVRPEVPEAIRKCQRAGIT-VRMVTGDNINTARAIAAKCGIIQpgedflclegkefnrr 739
Cdd:cd07544  403 GGTAVyvsvdgkyAGAITLRDEVRPEAKETLAHLRKAGVErLVMLTGDRRSVAEYIASEVGIDE---------------- 466
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  740 irnekgeieqerldkvwpklrVLARSSPTDKHTLVKGIidsttgEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVA 819
Cdd:cd07544  467 ---------------------VRAELLPEDKLAAVKEA------PKAGPTIMVGDGVNDAPALAAADVGIAMGARGSTAA 519
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....
gi 48255953  820 KEASDIILTDDNFTSIVKAVMWGRnvyDSISKFLQFQL---TVNVVAVIVAFTG 870
Cdd:cd07544  520 SEAADVVILVDDLDRVVDAVAIAR---RTRRIALQSVLigmALSIIGMLIAAFG 570
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
416-811 1.61e-24

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 110.94  E-value: 1.61e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  416 KFFIIGVTVLVVAVPEGLP----LAVTISLAYSVKKMMKDNNLVR-----HLDACetmgnataiCSDKTGTLTTNRMtVV 486
Cdd:cd07543  260 KLFLECTLILTSVVPPELPmelsLAVNTSLIALAKLYIFCTEPFRipfagKVDIC---------CFDKTGTLTSDDL-VV 329
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  487 QSYLGDTHYKE-IPAPSALTPKILDLLVHAISinsayttkiLPPEKEGALprqVGNKTECALLGFV---LDLKRDFQPVR 562
Cdd:cd07543  330 EGVAGLNDGKEvIPVSSIEPVETILVLASCHS---------LVKLDDGKL---VGDPLEKATLEAVdwtLTKDEKVFPRS 397
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  563 EQIPEDKLYKVYTFNSVRKSMSTVI---RMPDGGFRLFS--KGASEILLKKCTNIlnsngelrgfrPRDRDDMVRKiiep 637
Cdd:cd07543  398 KKTKGLKIIQRFHFSSALKRMSVVAsykDPGSTDLKYIVavKGAPETLKSMLSDV-----------PADYDEVYKE---- 462
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  638 MACDGLRTICIAYRDF---SAGQEPDWDNENeVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARA 714
Cdd:cd07543  463 YTRQGSRVLALGYKELghlTKQQARDYKRED-VESDLTFAGFIVFSCPLKPDSKETIKELNNSSHRVVMITGDNPLTACH 541
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  715 IAAKCGIIQpgedflclegkefNRRIRNEKGEIEQERLDKVWPKLRVLARSSPTDKHTLVkgiidSTTGEQRQVVAVTGD 794
Cdd:cd07543  542 VAKELGIVD-------------KPVLILILSEEGKSNEWKLIPHVKVFARVAPKQKEFII-----TTLKELGYVTLMCGD 603
                        410
                 ....*....|....*..
gi 48255953  795 GTNDGPALKKADVGFAM 811
Cdd:cd07543  604 GTNDVGALKHAHVGVAL 620
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
416-819 5.38e-24

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 109.22  E-value: 5.38e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  416 KFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMtVVQSYLGDTHY 495
Cdd:cd02082  252 FIAFEFLDILTYSVPPGLPMLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKL-DLIGYQLKGQN 330
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  496 KEIPAPSALTPKILDLLVHAISINSAyTTKIlppekEGALprqVGNKTECALLGFV-LDLKRDFQpvREQIPED------ 568
Cdd:cd02082  331 QTFDPIQCQDPNNISIEHKLFAICHS-LTKI-----NGKL---LGDPLDVKMAEAStWDLDYDHE--AKQHYSKsgtkrf 399
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  569 KLYKVYTFNSVRKSMSTVIRMPDGGFR-----LFSKGASEILLKKCTNIlnsngelrgfrPRDRDDMVRKIIEpmacDGL 643
Cdd:cd02082  400 YIIQVFQFHSALQRMSVVAKEVDMITKdfkhyAFIKGAPEKIQSLFSHV-----------PSDEKAQLSTLIN----EGY 464
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  644 RTICIAYRDFsaGQEPDWDNEN----EVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKC 719
Cdd:cd02082  465 RVLALGYKEL--PQSEIDAFLDlsreAQEANVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTALKVAQEL 542
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  720 GIIQPGEDFLCLEGKEfnrrIRNEKGEIEQERLdkvWPKLRVLARSSPTDKHTLVKGIidsttGEQRQVVAVTGDGTNDG 799
Cdd:cd02082  543 EIINRKNPTIIIHLLI----PEIQKDNSTQWIL---IIHTNVFARTAPEQKQTIIRLL-----KESDYIVCMCGDGANDC 610
                        410       420
                 ....*....|....*....|
gi 48255953  800 PALKKADVGFAMGIAGTDVA 819
Cdd:cd02082  611 GALKEADVGISLAEADASFA 630
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
196-901 7.83e-24

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 107.88  E-value: 7.83e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  196 TVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDlKIDESSLTGESDHVRKSA-DKdpmLLSGTHVMEGSGRM 274
Cdd:cd07546  102 LREENGERREVPADSLRPGDVIEVAPGGRLPADGELLSGFA-SFDESALTGESIPVEKAAgDK---VFAGSINVDGVLRI 177
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  275 VVTAVGVNSQTGIIFTLLgaggeeeekkdkkgkqqdgamessqtkakkqdgavamemqplksaeggemEEREKKKAnaPk 354
Cdd:cd07546  178 RVTSAPGDNAIDRILHLI--------------------------------------------------EEAEERRA--P- 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  355 keksvLQGKLTKLAVQIGKAGLVMSAITVIILVLYFvietfvveGRTWLaecTPVYVqyfvkffiiGVTVLVVAVPEGL- 433
Cdd:cd07546  205 -----IERFIDRFSRWYTPAIMAVALLVIVVPPLLF--------GADWQ---TWIYR---------GLALLLIGCPCALv 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  434 ---PLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqsylgdthykEIPAPSALTPKILD 510
Cdd:cd07546  260 istPAAITSGLAAAARRGA----LIKGGAALEQLGRVTTVAFDKTGTLTRGKPVVT----------DVVPLTGISEAELL 325
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  511 LLVHAISINSAY---TTKILPPEKEGALPRQVGNKTecALLGFVLDLKRDFQPVREQIPedklykvytfnsvrksmstvi 587
Cdd:cd07546  326 ALAAAVEMGSSHplaQAIVARAQAAGLTIPPAEEAR--ALVGRGIEGQVDGERVLIGAP--------------------- 382
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  588 RMPDGGFRLFSKGASEILlkkctnilnsngELRGfrprdrddmvrkiiepmacdglRTICIAYRdfsagqepdwdneNEV 667
Cdd:cd07546  383 KFAADRGTLEVQGRIAAL------------EQAG----------------------KTVVVVLA-------------NGR 415
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  668 VgdltcIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIiqpgeDFlclegkefnrrirneKGEI 747
Cdd:cd07546  416 V-----LGLIALRDELRPDAAEAVAELNALGIKALMLTGDNPRAAAAIAAELGL-----DF---------------RAGL 470
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  748 EQErlDKVwpklrvlarssptdkhtlvkGIIDSTTgeQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIIL 827
Cdd:cd07546  471 LPE--DKV--------------------KAVRELA--QHGPVAMVGDGINDAPAMKAASIGIAMG-SGTDVALETADAAL 525
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 48255953  828 TDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGacitqdsplkaVQMLWVNLIMDTFASlALAT 901
Cdd:cd07546  526 THNRLGGVAAMIELSRATLANIRQNITIALGLKAVFLVTTLLG-----------ITGLWLAVLADTGAT-VLVT 587
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
192-866 3.89e-22

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 103.06  E-value: 3.89e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  192 EQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLK----IDESSLTGESD-HVRKSADKDPMLLSGTH 266
Cdd:cd07536   82 KKQLYSKLTGRKVQIKSSDIQVGDIVIVEKNQRIPSDMVLLRTSEPQgscyVETAQLDGETDlKLRVAVSCTQQLPALGD 161
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  267 VMEGSGRMV--VTAVGVNSQTGIiFTLLGAGGEEEEKKDKKGKQqdgaMESSQTKAKKQDGAVamemqplkSAEGGEMEE 344
Cdd:cd07536  162 LMKISAYVEcqKPQMDIHSFEGN-FTLEDSDPPIHESLSIENTL----LRASTLRNTGWVIGV--------VVYTGKETK 228
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  345 REKKKANAPKKeKSVLQGKLTKLAVQIGKAGLVMSAITVIILVlyFVIETFVVEGRTWLAECTPVYVQYFVKF-FIIGVT 423
Cdd:cd07536  229 LVMNTSNAKNK-VGLLDLELNRLTKALFLALVVLSLVMVTLQG--FWGPWYGEKNWYIKKMDTTSDNFGRNLLrFLLLFS 305
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  424 VLVvavpeglPLAVTISL----AYSVKKMMKDNNL----------VRHLDACETMGNATAICSDKTGTLTTNRMTVVQSY 489
Cdd:cd07536  306 YII-------PISLRVNLdmvkAVYAWFIMWDENMyyigndtgtvARTSTIPEELGQVVYLLTDKTGTLTQNEMIFKRCH 378
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  490 LGDTHYkeipAPSALTPKILDLLvhaisinsayttkilppekegalprqvgnktecallgfvldlkrdfqpvreqipedk 569
Cdd:cd07536  379 IGGVSY----GGQVLSFCILQLL--------------------------------------------------------- 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  570 lykvyTFNSVRKSMSTVIRMPDGG-FRLFSKGASEILLKKCTnilnsngelRGFRPRDRDDMVrkiiEPMACDGLRTICI 648
Cdd:cd07536  398 -----EFTSDRKRMSVIVRDESTGeITLYMKGADVAISPIVS---------KDSYMEQYNDWL----EEECGEGLRTLCV 459
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  649 AYRDFSAGQEPDW------------DNENEVVG-------DLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNI 709
Cdd:cd07536  460 AKKALTENEYQEWesryteaslslhDRSLRVAEvveslerELELLGLTAIEDRLQAGVPETIETLRKAGIKIWMLTGDKQ 539
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  710 NTARAIAAKCGIIQP-------------GED-----FLCLEGKEFNRR------IRNEKGEIEQERLDKVWPKLRVLA-- 763
Cdd:cd07536  540 ETAICIAKSCHLVSRtqdihllrqdtsrGERaaitqHAHLELNAFRRKhdvalvIDGDSLEVALKYYRHEFVELACQCpa 619
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  764 ----RSSPTDKHTLVKgIIDSTTGeqRQVVAVtGDGTNDGPALKKADVGfaMGIAGTD--VAKEASDIILTddNFTSIVK 837
Cdd:cd07536  620 viccRVSPTQKARIVT-LLKQHTG--RRTLAI-GDGGNDVSMIQAADCG--VGISGKEgkQASLAADYSIT--QFRHLGR 691
                        730       740       750
                 ....*....|....*....|....*....|
gi 48255953  838 AVM-WGRNVYDSISKFLQFQLTVNVVAVIV 866
Cdd:cd07536  692 LLLvHGRNSYNRSAALGQYVFYKGLIISTI 721
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
519-612 3.43e-20

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 86.12  E-value: 3.43e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    519 NSAyttkILPPEKEGALPRQVGNKTECALLGFVLDLKRDFQPVREQIPedKLyKVYTFNSVRKSMSTVIRMP-DGGFRLF 597
Cdd:pfam13246    4 NSA----AFDENEEKGKWEIVGDPTESALLVFAEKMGIDVEELRKDYP--RV-AEIPFNSDRKRMSTVHKLPdDGKYRLF 76
                           90
                   ....*....|....*
gi 48255953    598 SKGASEILLKKCTNI 612
Cdd:pfam13246   77 VKGAPEIILDRCTTI 91
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
200-843 1.96e-19

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 94.25  E-value: 1.96e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  200 NGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANdLKIDESSLTGESDHV-RKSADKDPMLLSGTHVMegSGRMVVTa 278
Cdd:cd02078  103 DGKIEKVPATDLKKGDIVLVEAGDIIPADGEVIEGV-ASVDESAITGESAPViRESGGDRSSVTGGTKVL--SDRIKVR- 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  279 vgVNSQTGIIFTllgaggeeeekkdkkgkqqdgamessqtkakkqDGAVAMemqplksAEGGEmeeREKkkanAPkkeks 358
Cdd:cd02078  179 --ITANPGETFL---------------------------------DRMIAL-------VEGAS---RQK----TP----- 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  359 vlqgklTKLAVQIGKAGLvmSAITVIILVLYFVIETFVVegrtwlaecTPVYVqyfvkffIIGVTVLVVAVPE---GLPL 435
Cdd:cd02078  205 ------NEIALTILLVGL--TLIFLIVVATLPPFAEYSG---------APVSV-------TVLVALLVCLIPTtigGLLS 260
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  436 AVTISlaySVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTT-NRMTVvqsylgdthyKEIPAPSAlTPKILdllvh 514
Cdd:cd02078  261 AIGIA---GMDRLLRFNVIAKSGRAVEAAGDVDTLLLDKTGTITLgNRQAT----------EFIPVGGV-DEKEL----- 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  515 aisINSAYTTKILPPEKEG----ALPRQVGNKtecallgfvldlKRDFQPvreqipedKLYKVYTFnSVRKSMSTViRMP 590
Cdd:cd02078  322 ---ADAAQLASLADETPEGrsivILAKQLGGT------------ERDLDL--------SGAEFIPF-SAETRMSGV-DLP 376
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  591 DGgfRLFSKGASEILLKKctnILNSNGELrgfrprdrDDMVRKIIEPMACDGLRTICIAyrdfsagqepdwdNENEVVGd 670
Cdd:cd02078  377 DG--TEIRKGAVDAIRKY---VRSLGGSI--------PEELEAIVEEISKQGGTPLVVA-------------EDDRVLG- 429
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  671 ltciaVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIiqpgEDFLclegkefnrrirnekgeieqe 750
Cdd:cd02078  430 -----VIYLKDIIKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEAGV----DDFL--------------------- 479
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  751 rldkvwpklrvlARSSPTDKHTLVKgiidsTTGEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDD 830
Cdd:cd02078  480 ------------AEAKPEDKLELIR-----KEQAKGKLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEAGNMVDLDS 541
                        650
                 ....*....|...
gi 48255953  831 NFTSIVKAVMWGR 843
Cdd:cd02078  542 DPTKLIEVVEIGK 554
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
435-855 2.17e-18

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 90.93  E-value: 2.17e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  435 LAVTISLAYSV--KKMMKDNNL----VRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIPapsaLTPKI 508
Cdd:cd07541  288 LRVNLDMAKIVysWQIEHDKNIpgtvVRTSTIPEELGRIEYLLSDKTGTLTQNEMVFKKLHLGTVSYGGQN----LNYEI 363
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  509 LdllvhaisinsayttkilppekegalprqvgnktecallgfvldlkrdfqpvreqipedklyKVYTFNSVRKSMSTVIR 588
Cdd:cd07541  364 L--------------------------------------------------------------QIFPFTSESKRMGIIVR 381
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  589 MP-DGGFRLFSKGASEILlkkcTNILNSNgelrgfrprdrdDMVRKIIEPMACDGLRTICIAYRDFSAGQEPDWDNE--- 664
Cdd:cd07541  382 EEkTGEITFYMKGADVVM----SKIVQYN------------DWLEEECGNMAREGLRTLVVAKKKLSEEEYQAFEKRyna 445
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  665 ------------NEVVG----DLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEDF 728
Cdd:cd07541  446 aklsihdrdlkvAEVVEslerELELLCLTGVEDKLQEDVKPTLELLRNAGIKIWMLTGDKLETATCIAKSSKLVSRGQYI 525
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  729 -----LCLEGKEFN-----RRIRNEK------------GEIEQERLDKVWPKLRVLA-RSSPTDKHTLVKGIIDSTtgeQ 785
Cdd:cd07541  526 hvfrkVTTREEAHLelnnlRRKHDCAlvidgeslevclKYYEHEFIELACQLPAVVCcRCSPTQKAQIVRLIQKHT---G 602
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 48255953  786 RQVVAVtGDGTNDGPALKKADVGfaMGIAGTDvAKEAS---DIILTDdnFTSIVKAVMW-GRNVYDSISKFLQF 855
Cdd:cd07541  603 KRTCAI-GDGGNDVSMIQAADVG--VGIEGKE-GKQASlaaDFSITQ--FSHIGRLLLWhGRNSYKRSAKLAQF 670
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
196-843 5.20e-17

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 86.14  E-value: 5.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  196 TVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLkIDESSLTGESdhVRKSADKDPMLLSGThvmegsgrmv 275
Cdd:cd07548  112 NLKRNNELKDVKPEEVQIGDIIVVKPGEKIPLDGVVLKGESF-LDTSALTGES--VPVEVKEGSSVLAGF---------- 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  276 vtavgVNsQTGIIftllgaggeeeekkdkkgkqqdgameSSQTKAKKQDGAVAMEMQPLKSAEGgemeerekkkanapkk 355
Cdd:cd07548  179 -----IN-LNGVL--------------------------EIKVTKPFKDSAVAKILELVENASA---------------- 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  356 EKSVLQGKLTKLAvqigkagLVMSAITVIILVLYFVIETFVVEG---RTWLAEctpvyvqyfvkffiiGVTVLVVAVPEG 432
Cdd:cd07548  211 RKAPTEKFITKFA-------RYYTPIVVFLALLLAVIPPLFSPDgsfSDWIYR---------------ALVFLVISCPCA 268
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  433 LPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqsylgdthyKEIPAPSALTPKILDLL 512
Cdd:cd07548  269 LVISIPLGYFGGIGAASRKGILIKGSNYLEALSQVKTVVFDKTGTLTKGVFKVT---------EIVPAPGFSKEELLKLA 339
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  513 VH---------AISINSAYTTKILPPEkegalprqVGNKTECALLGfvldlkrdfqpVREQIPEDKLYKvytfnsvrksm 583
Cdd:cd07548  340 ALaesnsnhpiARSIQKAYGKMIDPSE--------IEDYEEIAGHG-----------IRAVVDGKEILV----------- 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  584 stvirmpdGGFRLFSKgaseillkkcTNILNSNGELRGfrprdrddmvrkiiepmacdglRTICIAYrdfsagqepdwdn 663
Cdd:cd07548  390 --------GNEKLMEK----------FNIEHDEDEIEG----------------------TIVHVAL------------- 416
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  664 ENEVVGdltCIAvvgIEDPVRPEVPEAIRKCQRAGIT-VRMVTGDNINTARAIAAKCGIiqpgedflclegkefnrrirn 742
Cdd:cd07548  417 DGKYVG---YIV---ISDEIKEDAKEAIKGLKELGIKnLVMLTGDRKSVAEKVAKKLGI--------------------- 469
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  743 ekgeieqerlDKVWPKLrvlarsSPTDKHTLVKGIIDSTTGEqrqvVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEA 822
Cdd:cd07548  470 ----------DEVYAEL------LPEDKVEKVEELKAESKGK----VAFVGDGINDAPVLARADVGIAMGGLGSDAAIEA 529
                        650       660
                 ....*....|....*....|.
gi 48255953  823 SDIILTDDNFTSIVKAVMWGR 843
Cdd:cd07548  530 ADVVLMNDEPSKVAEAIKIAR 550
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
196-828 6.89e-16

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 82.73  E-value: 6.89e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   196 TVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQAnDLKIDESSLTGESDHV-RKSADKdpmllsgthVMEGSgrM 274
Cdd:PRK11033  246 TRLRDGEREEVAIADLRPGDVIEVAAGGRLPADGKLLSP-FASFDESALTGESIPVeRATGEK---------VPAGA--T 313
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   275 VVtavgvnsqtgiiftllgaggeeeekkdkkgkqqdgamessqtkakkqDGAVAMEMqplkSAEGGE---------MEER 345
Cdd:PRK11033  314 SV-----------------------------------------------DRLVTLEV----LSEPGAsaidrilhlIEEA 342
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   346 EKKKAnaPkkeksvLQGKLTKLAVQIGKAGLVMSAITVIILVLYFvietfvveGRTWLaecTPVYVqyfvkffiiGVTVL 425
Cdd:PRK11033  343 EERRA--P------IERFIDRFSRIYTPAIMLVALLVILVPPLLF--------AAPWQ---EWIYR---------GLTLL 394
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   426 VVAVPEGL----PLAVTISLAYSVKKmmkdNNLVRHLDACETMGNATAICSDKTGTLT--TNRMTVVQSYLGdthykeIP 499
Cdd:PRK11033  395 LIGCPCALvistPAAITSGLAAAARR----GALIKGGAALEQLGRVTTVAFDKTGTLTegKPQVTDIHPATG------IS 464
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   500 APSALTpkildlLVHAISINSAYttkilppekegALPRQVGNKTECALLGFVLDLKRDFQP---VREQIpEDKLYKVYTf 576
Cdd:PRK11033  465 ESELLA------LAAAVEQGSTH-----------PLAQAIVREAQVRGLAIPEAESQRALAgsgIEGQV-NGERVLICA- 525
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   577 nsvrksmstvirmPDGGFRLFSKGASEILLkkctniLNSNGElrgfrprdrddmvrkiiepmacdglrTICIAYRDfsag 656
Cdd:PRK11033  526 -------------PGKLPPLADAFAGQINE------LESAGK--------------------------TVVLVLRN---- 556
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   657 qepdwdneNEVVGdltciaVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIiqpgeDFlclegkef 736
Cdd:PRK11033  557 --------DDVLG------LIALQDTLRADARQAISELKALGIKGVMLTGDNPRAAAAIAGELGI-----DF-------- 609
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   737 nrrirnekgeieqerldkvwpklrvlaRSS--PTDKhtlVKGIIDSTtgeQRQVVAVTGDGTNDGPALKKADVGFAMGiA 814
Cdd:PRK11033  610 ---------------------------RAGllPEDK---VKAVTELN---QHAPLAMVGDGINDAPAMKAASIGIAMG-S 655
                         650
                  ....*....|....
gi 48255953   815 GTDVAKEASDIILT 828
Cdd:PRK11033  656 GTDVALETADAALT 669
kdpB TIGR01497
K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the ...
667-871 2.27e-15

K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit, while KdpF serves to stabilize the complex. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB). Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130561 [Multi-domain]  Cd Length: 675  Bit Score: 81.08  E-value: 2.27e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    667 VVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIiqpgEDFLclegkefnrrirnekge 746
Cdd:TIGR01497  431 VCEDNRIYGVIYLKDIVKGGIKERFAQLRKMGIKTIMITGDNRLTAAAIAAEAGV----DDFI----------------- 489
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    747 ieqerldkvwpklrvlARSSPTDKHTLVKGIIDsttgeQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDII 826
Cdd:TIGR01497  490 ----------------AEATPEDKIALIRQEQA-----EGKLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEAANMV 547
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 48255953    827 LTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVV---AVI-VAFTGA 871
Cdd:TIGR01497  548 DLDSDPTKLIEVVHIGKQLLITRGALTTFSIANDVAkyfAIIpAIFAAA 596
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
200-881 3.37e-15

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 80.48  E-value: 3.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  200 NGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLkIDESSLTGESDHVRksADKDPMLLSGTHVMEGSGRMVVTAV 279
Cdd:cd02092  134 DGSREYVPVAEIRPGDRVLVAAGERIPVDGTVVSGTSE-LDRSLLTGESAPVT--VAPGDLVQAGAMNLSGPLRLRATAA 210
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  280 GvnsqtgiiftllgaggeeeekkdkkgkqqdgamessqtkakkqDGAVAMEMQPLksaeggeMEEREKKKAnapkkeksv 359
Cdd:cd02092  211 G-------------------------------------------DDTLLAEIARL-------MEAAEQGRS--------- 231
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  360 lqgKLTKLAVQIgkAGLVMSAITVIILVlyfvieTFVVegrtWLAECTPVYVQyfvkfFIIGVTVLVVAVPEGLPLAVTI 439
Cdd:cd02092  232 ---RYVRLADRA--ARLYAPVVHLLALL------TFVG----WVAAGGDWRHA-----LLIAVAVLIITCPCALGLAVPA 291
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  440 SLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIPAPSALTPKildllvHAISIN 519
Cdd:cd02092  292 VQVVASGRLFRRGVLVKDGTALERLAEVDTVVFDKTGTLTLGSPRLVGAHAISADLLALAAALAQASR------HPLSRA 365
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  520 SAYTTkilppekeGALPRQVGNKTECAllGFVLDLKRDFQPVREQIPEdklykvytFNSVRKSMSTvirmpdggfrlfsk 599
Cdd:cd02092  366 LAAAA--------GARPVELDDAREVP--GRGVEGRIDGARVRLGRPA--------WLGASAGVST-------------- 413
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  600 gASEILLKKctnilnsngelrgfrprdrddmvrkiiepmacdglrticiayrdfsAGQEPDWdnenevvgdltciavVGI 679
Cdd:cd02092  414 -ASELALSK----------------------------------------------GGEEAAR---------------FPF 431
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  680 EDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQpgedflclegkefnrrirnekgeieqerldkvwpkl 759
Cdd:cd02092  432 EDRPRPDAREAISALRALGLSVEILSGDREPAVRALARALGIED------------------------------------ 475
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  760 rVLARSSPTDKHTLvkgiIDSTTGEQRQVVAVtGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFTSIVKAV 839
Cdd:cd02092  476 -WRAGLTPAEKVAR----IEELKAQGRRVLMV-GDGLNDAPALAAAHVSMAPASA-VDASRSAADIVFLGDSLAPVPEAI 548
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|..
gi 48255953  840 MWGRNVYDSISKFLQFQLTVNVVAVIVAFTGacitQDSPLKA 881
Cdd:cd02092  549 EIARRARRLIRQNFALAIGYNVIAVPLAIAG----YVTPLIA 586
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
51-120 3.57e-15

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 71.05  E-value: 3.57e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953     51 EAYGDVSGLCRRLKTSPTEGLadNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIV 120
Cdd:pfam00690    1 WHALSVEEVLKKLGTDLEKGL--TEAEAEKRLKKYGPNELPEKKPKSLWKLFLRQFKDPLIIILLIAAIV 68
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
214-881 3.22e-14

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 77.17  E-value: 3.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  214 GDIAQVKYGDLLPADGVLI--QANdlkIDESSLTGESDHVRK-SADKDPmllSGTHVMEGSGRMVVTAVGVNSQTGIIFT 290
Cdd:cd07553  149 GDVYLVASGQRVPVDGKLLseQAS---IDMSWLTGESLPRIVeRGDKVP---AGTSLENQAFEIRVEHSLAESWSGSILQ 222
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  291 llgaggeeeekkdkkgkqqdgamessqtkakkqdgavamemqplksaeggEMEEREKKKAnapkkeksvlqgKLTKLAVQ 370
Cdd:cd07553  223 --------------------------------------------------KVEAQEARKT------------PRDLLADK 240
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  371 IGkaglvmSAITVIILVLYFVIETFvvegrtWLAECTPVYVQYFVkffiigvTVLVVAVPEGLPLAVTISLAYSVKKMMK 450
Cdd:cd07553  241 II------HYFTVIALLIAVAGFGV------WLAIDLSIALKVFT-------SVLIVACPCALALATPFTDEIALARLKK 301
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  451 DNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSylgdthykeipAPSALTpkiLDLLVHAISInsayttkilppe 530
Cdd:cd07553  302 KGVLIKNASSLERLSRVRTIVFDKTGTLTRGKSSFVMV-----------NPEGID---RLALRAISAI------------ 355
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  531 kEGALPRQVGNktecallgfvldLKRDFQPVREqipedklykvytfnSVRKSMSTVIRMPDGGFRLFSKGaSEILLKKCt 610
Cdd:cd07553  356 -EAHSRHPISR------------AIREHLMAKG--------------LIKAGASELVEIVGKGVSGNSSG-SLWKLGSA- 406
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  611 nilnsngelrgfrprdrddmvrkiiePMACDGLRTICIAYRDFSAgqepdwdnenevvgdltcIAVVGIEDPVRPEVPEA 690
Cdd:cd07553  407 --------------------------PDACGIQESGVVIARDGRQ------------------LLDLSFNDLLRPDSNRE 442
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  691 IRKCQRAGITVRMVTGDNINTARAIAAKCGiiqpgedflclegkefnrrirnekgeieqerLDKVwpklRVLARSSPTDK 770
Cdd:cd07553  443 IEELKKGGLSIAILSGDNEEKVRLVGDSLG-------------------------------LDPR----QLFGNLSPEEK 487
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  771 HTLVKgiidstTGEQRQVVAVtGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSIS 850
Cdd:cd07553  488 LAWIE------SHSPENTLMV-GDGANDALALASAFVGIAVA-GEVGVSLEAADIYYAGNGIGGIRDLLTLSKQTIKAIK 559
                        650       660       670
                 ....*....|....*....|....*....|.
gi 48255953  851 KFLQFQLTVNVVAVIVAFTGACitqdSPLKA 881
Cdd:cd07553  560 GLFAFSLLYNLVAIGLALSGWI----SPLVA 586
copA PRK10671
copper-exporting P-type ATPase CopA;
674-839 1.86e-13

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 75.16  E-value: 1.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   674 IAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQpgedflclegkefnrrirnekgeieqerld 753
Cdd:PRK10671  642 AALLAIRDPLRSDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAGIDE------------------------------ 691
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   754 kvwpklrVLARSSPTDKHTLVKgiidsTTGEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFT 833
Cdd:PRK10671  692 -------VIAGVLPDGKAEAIK-----RLQSQGRQVAMVGDGINDAPALAQADVGIAMG-GGSDVAIETAAITLMRHSLM 758

                  ....*.
gi 48255953   834 SIVKAV 839
Cdd:PRK10671  759 GVADAL 764
PLN03190 PLN03190
aminophospholipid translocase; Provisional
418-715 1.28e-11

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 69.16  E-value: 1.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   418 FIIGVTVLVVAVPEGLPLA---VTISLAYSvkkMMKDNNL----------VRHLDACETMGNATAICSDKTGTLTTNRMT 484
Cdd:PLN03190  394 FLMSVIVFQIMIPISLYISmelVRVGQAYF---MIRDDQMydeasnsrfqCRALNINEDLGQIKYVFSDKTGTLTENKME 470
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   485 VVQSYLGDTHYKEIPAPS----------------------ALTPKILDLL-----------VHAISINSAYTTKILP--- 528
Cdd:PLN03190  471 FQCASIWGVDYSDGRTPTqndhagysvevdgkilrpkmkvKVDPQLLELSksgkdteeakhVHDFFLALAACNTIVPivv 550
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   529 ----------PEKEGALPRQVGNKTECALLGFVLDLKRDFQPVREQIPEDKLYKV---YTFNSVRKSMSTVIRMPDGGFR 595
Cdd:PLN03190  551 ddtsdptvklMDYQGESPDEQALVYAAAAYGFMLIERTSGHIVIDIHGERQRFNVlglHEFDSDRKRMSVILGCPDKTVK 630
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   596 LFSKGASEILLKKCTNILNSN------GELRGFrprdrddmvrkiiepmACDGLRTICIAYRDFSAGQEPDWDNENE--- 666
Cdd:PLN03190  631 VFVKGADTSMFSVIDRSLNMNvirateAHLHTY----------------SSLGLRTLVVGMRELNDSEFEQWHFSFEaas 694
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 48255953   667 --VVG--------------DLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAI 715
Cdd:PLN03190  695 taLIGraallrkvasnvenNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISI 759
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
59-124 4.19e-11

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 59.90  E-value: 4.19e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 48255953      59 LCRRLKTSPTEGLadNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGL 124
Cdd:smart00831   12 VLERLQTDLEKGL--SSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
664-861 2.05e-10

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 65.11  E-value: 2.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   664 ENEVVgdltcIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIqpgedflclegkefnrrirne 743
Cdd:PRK14010  428 EDNEI-----LGVIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGVD--------------------- 481
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953   744 kgeieqerldkvwpklRVLARSSPTDKHTLVKgiidsTTGEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEAS 823
Cdd:PRK14010  482 ----------------RFVAECKPEDKINVIR-----EEQAKGHIVAMTGDGTNDAPALAEANVGLAMN-SGTMSAKEAA 539
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 48255953   824 DIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNV 861
Cdd:PRK14010  540 NLIDLDSNPTKLMEVVLIGKQLLMTRGSLTTFSIANDI 577
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1100-1145 1.19e-08

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 52.02  E-value: 1.19e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 48255953   1100 GQILWFRGLNRIQTQMEVVSTFkRSGSVQGAvrRRSSVLSQLHDVT 1145
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAF-QSSLREGI--QKPYLRNSIHSFM 43
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
664-806 5.25e-08

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 54.13  E-value: 5.25e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    664 ENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEDFLCLEGKEFnrrirne 743
Cdd:pfam00702   80 LTVVLVELLGVIALADELKLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYFDVVISGDDVGV------- 152
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 48255953    744 kgeieqerldkvwpklrvlARSSPTDKHTLVKGIidsttGEQRQVVAVTGDGTNDGPALKKAD 806
Cdd:pfam00702  153 -------------------GKPKPEIYLAALERL-----GVKPEEVLMVGDGVNDIPAAKAAG 191
Pglycolate_arch TIGR01487
phosphoglycolate phosphatase, TA0175-type; This group of Archaeal sequences, now known to be ...
685-839 7.19e-06

phosphoglycolate phosphatase, TA0175-type; This group of Archaeal sequences, now known to be phosphoglycolate phosphatases, is most closely related to the sucrose-phosphate phosphatases from plants and cyanobacteria (TIGR01485). Together, these two models comprise a subfamily model (TIGR01482). TIGR01482, in turn, is a member of the IIB subfamily (TIGR01484) of the Haloacid Dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases.


Pssm-ID: 273652 [Multi-domain]  Cd Length: 215  Bit Score: 48.20  E-value: 7.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    685 PEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQP--GED-----------FLCLEGKEFNRRIRNEKGEIeQER 751
Cdd:TIGR01487   21 ERAIEAIRKAEKKGIPVSLVTGNTVPFARALAVLIGTSGPvvAENggvifynkediFLANMEEEWFLDEEKKKRFP-RDR 99
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    752 LDKVWP---------------------KLRVLARSSPTDKHTLVKGI--------IDSTTGEQRQVVAVTGDGTNDGPAL 802
Cdd:TIGR01487  100 LSNEYPraslvimregkdvdevreiikERGLNLVASGFAIHIMKKGVdkgvgvekLKELLGIKPEEVAAIGDSENDIDLF 179
                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 48255953    803 KKADVGFAMGIAgTDVAKEASDIILTDDNFTSIVKAV 839
Cdd:TIGR01487  180 RVVGFKVAVANA-DDQLKEIADYVTSNPYGEGVVEVL 215
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
685-831 7.53e-05

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 44.74  E-value: 7.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  685 PEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPgedFLCLEGKEfnrrIRNEKGE------IEQERLDKVWPK 758
Cdd:COG0561   22 PRTKEALRRLREKGIKVVIATGRPLRSALPLLEELGLDDP---LITSNGAL----IYDPDGEvlyerpLDPEDVREILEL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953  759 LR-------VLARSSPT---------DK----HTLVK--GIidsttgEQRQVVAVtGDGTNDGPALKKADVGFAMGIAgT 816
Cdd:COG0561   95 LRehglhlqVVVRSGPGfleilpkgvSKgsalKKLAErlGI------PPEEVIAF-GDSGNDLEMLEAAGLGVAMGNA-P 166
                        170
                 ....*....|....*
gi 48255953  817 DVAKEASDIIlTDDN 831
Cdd:COG0561  167 PEVKAAADYV-TGSN 180
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
789-831 8.38e-04

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 42.64  E-value: 8.38e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 48255953    789 VAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIIlTDDN 831
Cdd:TIGR00099  207 VIAFGDGMNDIEMLEAAGYGVAMGNA-DEELKALADYV-TDSN 247
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
740-838 1.68e-03

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 41.45  E-value: 1.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    740 IRNEKGEIEQ--ERLDKVWPKLRVLARSSP---------TDKHTLVKGIIDSTTGEQRQVVAVtGDGTNDGPALKKADVG 808
Cdd:pfam08282  147 ILLDEEDLDEleKELKELFGSLITITSSGPgyleimpkgVSKGTALKALAKHLNISLEEVIAF-GDGENDIEMLEAAGLG 225
                           90       100       110
                   ....*....|....*....|....*....|
gi 48255953    809 FAMGIAgTDVAKEASDIILTDDNFTSIVKA 838
Cdd:pfam08282  226 VAMGNA-SPEVKAAADYVTDSNNEDGVAKA 254
HAD-SF-IB TIGR01488
Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; This model ...
682-805 2.67e-03

Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; This model represents a subfamily of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. Subfamily IA, B, C and D are distinguished from the rest of the superfamily by the presence of a variable domain between the first and second conserved catalytic motifs. In subfamilies IA and IB, this domain consists of an alpha-helical bundle. It was necessary to model these two subfamilies separately, breaking them at a an apparent phylogenetic bifurcation, so that the resulting model(s) are not so broadly defined that members of subfamily III (which lack the variable domain) are included. Subfamily IA includes the enzyme phosphoserine phosphatase (TIGR00338) as well as three hypothetical equivalogs. Many members of these hypothetical equivalogs have been annotated as PSPase-like or PSPase-family proteins. In particular, the hypothetical equivalog which appears to be most closely related to PSPase contains only Archaea (while TIGR00338 contains only eukaryotes and bacteria) of which some are annotated as PSPases. Although this is a reasonable conjecture, none of these sequences has sufficient evidence for this assignment. If such should be found, this model should be retired while the PSPase model should be broadened to include these sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273653 [Multi-domain]  Cd Length: 177  Bit Score: 40.03  E-value: 2.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255953    682 PVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIiqpgEDFLC--LEGKEFNRRIRNEKGEIEQERLDKVwPKL 759
Cdd:TIGR01488   73 ALRPGARELISWLKERGIDTVIVSGGFDFFVEPVAEKLGI----DDVFAnrLEFDDNGLLTGPIEGQVNPEGECKG-KVL 147
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 48255953    760 RVLARSSPTDKhtlvkgiidsttgeqRQVVAVtGDGTNDGPALKKA 805
Cdd:TIGR01488  148 KELLEESKITL---------------KKIIAV-GDSVNDLPMLKLA 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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