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Conserved domains on  [gi|62241026|ref|NP_068770|]
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doublesex- and mab-3-related transcription factor 1 isoform 1 [Homo sapiens]

Protein Classification

DMRTA family protein; doublesex- and mab-3-related transcription factor A2( domain architecture ID 10465276)

DMRTA (doublesex- and mab-3-related transcription factor A) family protein, similar to Caenorhabditis elegans doublesex- and mab-3-related transcription factor dmd-4; doublesex- and mab-3-related transcription factor A2 (DMRTA2) may be involved in sexual development

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DM pfam00751
DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single ...
 72-118 6.15e-29

DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerize and bind palindromic DNA.


:

Pssm-ID: 459924  Cd Length: 47  Bit Score: 106.21  E-value: 6.15e-29
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 62241026    72 RLPKCARCRNHGYASPLKGHKRFCMWRDCQCKKCNLIAERQRVMAAQ 118
Cdd:pfam00751   1 RSPKCARCRNHGVRVPLKGHKRYCPYRDCSCPKCLLVAERQRVMAAQ 47
Dmrt1 pfam12374
Double-sex mab3 related transcription factor 1; This domain family is found in eukaryotes, and ...
 130-202 1.90e-22

Double-sex mab3 related transcription factor 1; This domain family is found in eukaryotes, and is typically between 61 and 73 amino acids in length. The family is found in association with pfam00751. This family is a transcription factor involved in sex determination. The proteins in this family contain a zinc finger-like DNA-binding motif, DM domain.


:

Pssm-ID: 463555  Cd Length: 71  Bit Score: 89.81  E-value: 1.90e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62241026   130 ELGISHPIPLPsAAELLVKRENNGSnpCLMTECSGTSQP-PPASVPTTAASEGRMVIQDIPAVTSRGHVENTPD 202
Cdd:pfam12374   1 ELGISSPVPLP-GAEVLVKNEAGAD--CLFSESGSSPTPtSSSTAASSAATGGRSLISDIPSAASRGHLEGTSD 71
 
Name Accession Description Interval E-value
DM pfam00751
DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single ...
 72-118 6.15e-29

DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerize and bind palindromic DNA.


Pssm-ID: 459924  Cd Length: 47  Bit Score: 106.21  E-value: 6.15e-29
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 62241026    72 RLPKCARCRNHGYASPLKGHKRFCMWRDCQCKKCNLIAERQRVMAAQ 118
Cdd:pfam00751   1 RSPKCARCRNHGVRVPLKGHKRYCPYRDCSCPKCLLVAERQRVMAAQ 47
DM smart00301
Doublesex DNA-binding motif;
72-125 4.93e-23

Doublesex DNA-binding motif;


Pssm-ID: 214606  Cd Length: 54  Bit Score: 90.88  E-value: 4.93e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 62241026     72 RLPKCARCRNHGYASPLKGHKRFCMWRDCQCKKCNLIAERQRVMAAQVALRRQQ 125
Cdd:smart00301   1 RIPYCQKCENHGVKVPLKGHKPECPFRDCECEKCTLVEKRRALMALQIKLKREQ 54
Dmrt1 pfam12374
Double-sex mab3 related transcription factor 1; This domain family is found in eukaryotes, and ...
 130-202 1.90e-22

Double-sex mab3 related transcription factor 1; This domain family is found in eukaryotes, and is typically between 61 and 73 amino acids in length. The family is found in association with pfam00751. This family is a transcription factor involved in sex determination. The proteins in this family contain a zinc finger-like DNA-binding motif, DM domain.


Pssm-ID: 463555  Cd Length: 71  Bit Score: 89.81  E-value: 1.90e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62241026   130 ELGISHPIPLPsAAELLVKRENNGSnpCLMTECSGTSQP-PPASVPTTAASEGRMVIQDIPAVTSRGHVENTPD 202
Cdd:pfam12374   1 ELGISSPVPLP-GAEVLVKNEAGAD--CLFSESGSSPTPtSSSTAASSAATGGRSLISDIPSAASRGHLEGTSD 71
 
Name Accession Description Interval E-value
DM pfam00751
DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single ...
 72-118 6.15e-29

DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerize and bind palindromic DNA.


Pssm-ID: 459924  Cd Length: 47  Bit Score: 106.21  E-value: 6.15e-29
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 62241026    72 RLPKCARCRNHGYASPLKGHKRFCMWRDCQCKKCNLIAERQRVMAAQ 118
Cdd:pfam00751   1 RSPKCARCRNHGVRVPLKGHKRYCPYRDCSCPKCLLVAERQRVMAAQ 47
DM smart00301
Doublesex DNA-binding motif;
72-125 4.93e-23

Doublesex DNA-binding motif;


Pssm-ID: 214606  Cd Length: 54  Bit Score: 90.88  E-value: 4.93e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 62241026     72 RLPKCARCRNHGYASPLKGHKRFCMWRDCQCKKCNLIAERQRVMAAQVALRRQQ 125
Cdd:smart00301   1 RIPYCQKCENHGVKVPLKGHKPECPFRDCECEKCTLVEKRRALMALQIKLKREQ 54
Dmrt1 pfam12374
Double-sex mab3 related transcription factor 1; This domain family is found in eukaryotes, and ...
 130-202 1.90e-22

Double-sex mab3 related transcription factor 1; This domain family is found in eukaryotes, and is typically between 61 and 73 amino acids in length. The family is found in association with pfam00751. This family is a transcription factor involved in sex determination. The proteins in this family contain a zinc finger-like DNA-binding motif, DM domain.


Pssm-ID: 463555  Cd Length: 71  Bit Score: 89.81  E-value: 1.90e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62241026   130 ELGISHPIPLPsAAELLVKRENNGSnpCLMTECSGTSQP-PPASVPTTAASEGRMVIQDIPAVTSRGHVENTPD 202
Cdd:pfam12374   1 ELGISSPVPLP-GAEVLVKNEAGAD--CLFSESGSSPTPtSSSTAASSAATGGRSLISDIPSAASRGHLEGTSD 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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