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Conserved domains on  [gi|126723501|ref|NP_068834|]
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zinc finger protein 277 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10579336)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0003677|GO:0008270|GO:0003700
PubMed:  11179890|12665246|11361095|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-C2H2_2 pfam12756
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 175-262 1.72e-19

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


:

Pssm-ID: 463690  Cd Length: 98  Bit Score: 83.10  E-value: 1.72e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126723501  175 CMFCNEEFlGNRSVILNHMAREHAFNIGLPDNIVNCNEFLCTLQKKL-DNLQCLYCEKTFRDKNTLKDHMRKKQHRKINP 253
Cdd:pfam12756   1 CLFCGHTS-STVEENLEHMFKSHGFFIPEREYLVDLEGLLNYLREKIgLGNECLYCGKQFKSLEALRQHMRDKGHCKIPY 79

                          90
                  ....*....|...
gi 126723501  254 KNR----EYDRFY 262
Cdd:pfam12756  80 ESEeewlEIAEFY 92
zf-C2H2_2 pfam12756
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 304-401 4.14e-19

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


:

Pssm-ID: 463690  Cd Length: 98  Bit Score: 81.95  E-value: 4.14e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126723501  304 CLFCEKQAETIEKLYVHMEDAHEFDLLKIKselglNFYQQVKLVNFIRRQVH-QCRCYGCHVKFKSKADLRTHMEETKHT 382
Cdd:pfam12756   1 CLFCGHTSSTVEENLEHMFKSHGFFIPERE-----YLVDLEGLLNYLREKIGlGNECLYCGKQFKSLEALRQHMRDKGHC 75

                          90       100
                  ....*....|....*....|
gi 126723501  383 SLLPDRKT-WDQLEYYFPTY 401
Cdd:pfam12756  76 KIPYESEEeWLEIAEFYDFS 95
 
Name Accession Description Interval E-value
zf-C2H2_2 pfam12756
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 175-262 1.72e-19

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


Pssm-ID: 463690  Cd Length: 98  Bit Score: 83.10  E-value: 1.72e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126723501  175 CMFCNEEFlGNRSVILNHMAREHAFNIGLPDNIVNCNEFLCTLQKKL-DNLQCLYCEKTFRDKNTLKDHMRKKQHRKINP 253
Cdd:pfam12756   1 CLFCGHTS-STVEENLEHMFKSHGFFIPEREYLVDLEGLLNYLREKIgLGNECLYCGKQFKSLEALRQHMRDKGHCKIPY 79

                          90
                  ....*....|...
gi 126723501  254 KNR----EYDRFY 262
Cdd:pfam12756  80 ESEeewlEIAEFY 92
zf-C2H2_2 pfam12756
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 304-401 4.14e-19

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


Pssm-ID: 463690  Cd Length: 98  Bit Score: 81.95  E-value: 4.14e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126723501  304 CLFCEKQAETIEKLYVHMEDAHEFDLLKIKselglNFYQQVKLVNFIRRQVH-QCRCYGCHVKFKSKADLRTHMEETKHT 382
Cdd:pfam12756   1 CLFCGHTSSTVEENLEHMFKSHGFFIPERE-----YLVDLEGLLNYLREKIGlGNECLYCGKQFKSLEALRQHMRDKGHC 75

                          90       100
                  ....*....|....*....|
gi 126723501  383 SLLPDRKT-WDQLEYYFPTY 401
Cdd:pfam12756  76 KIPYESEEeWLEIAEFYDFS 95
 
Name Accession Description Interval E-value
zf-C2H2_2 pfam12756
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 175-262 1.72e-19

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


Pssm-ID: 463690  Cd Length: 98  Bit Score: 83.10  E-value: 1.72e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126723501  175 CMFCNEEFlGNRSVILNHMAREHAFNIGLPDNIVNCNEFLCTLQKKL-DNLQCLYCEKTFRDKNTLKDHMRKKQHRKINP 253
Cdd:pfam12756   1 CLFCGHTS-STVEENLEHMFKSHGFFIPEREYLVDLEGLLNYLREKIgLGNECLYCGKQFKSLEALRQHMRDKGHCKIPY 79

                          90
                  ....*....|...
gi 126723501  254 KNR----EYDRFY 262
Cdd:pfam12756  80 ESEeewlEIAEFY 92
zf-C2H2_2 pfam12756
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 304-401 4.14e-19

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


Pssm-ID: 463690  Cd Length: 98  Bit Score: 81.95  E-value: 4.14e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126723501  304 CLFCEKQAETIEKLYVHMEDAHEFDLLKIKselglNFYQQVKLVNFIRRQVH-QCRCYGCHVKFKSKADLRTHMEETKHT 382
Cdd:pfam12756   1 CLFCGHTSSTVEENLEHMFKSHGFFIPERE-----YLVDLEGLLNYLREKIGlGNECLYCGKQFKSLEALRQHMRDKGHC 75

                          90       100
                  ....*....|....*....|
gi 126723501  383 SLLPDRKT-WDQLEYYFPTY 401
Cdd:pfam12756  76 KIPYESEEeWLEIAEFYDFS 95
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 226-249 4.57e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 34.45  E-value: 4.57e-03
                          10        20
                  ....*....|....*....|....
gi 126723501  226 CLYCEKTFRDKNTLKDHMRKKQHR 249
Cdd:pfam12171   4 CVLCDKYFKSENALQNHLKSKKHK 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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