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Conserved domains on  [gi|26667177|ref|NP_071446|]
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large ribosomal subunit protein mL46 [Homo sapiens]

Protein Classification

MRP-L46 and MRP_L46 domain-containing protein( domain architecture ID 10570399)

MRP-L46 and MRP_L46 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NUDIX_MRP_L46 cd04661
Mitochondrial ribosomal protein L46; Mitochondrial ribosomal protein L46 (MRP L46) is a ...
 136-275 1.87e-54

Mitochondrial ribosomal protein L46; Mitochondrial ribosomal protein L46 (MRP L46) is a component of the large subunit (39S) of the mammalian mitochondrial ribosome and a member of the NUDIX hydrolase superfamily. MRPs are thought to be involved in the maintenance of the mitochondrial DNA. In general, members of the NUDIX hydrolase superfamily require a divalent cation, such as Mg2+ or Mn2+, for activity and contain the NUDIX motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. MRP L46 appears to contain a modified NUDIX motif.


:

Pssm-ID: 467546  Cd Length: 142  Bit Score: 172.80  E-value: 1.87e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26667177 136 RITEADEKNDRTSLNRKLDRNLVLLVREKFGdQDVWILPQAEWQPGETLRGTAERTLATLSENNMEAKFLGNAPCGHYTF 215
Cdd:cd04661  10 RLPEADEKNDRKSLERKLDRTLYLLVKQKKG-KGPWQFPQGDVEEGETLREAAERGLRELGGDNMNTWFVGNAPIGVYKY 88

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 26667177 216 KFPQAMRTEsnlGAKVFFFKALLltgDFSQAGNKGHHVWVTKDELGDYLKPKYLAQVRRF 275
Cdd:cd04661  89 KYPKKTKEF---GYKSFFLKGRF---MPGQKKGVSDFAWLTKEELKEYVDPEYWKSVKKM 142
MRP-L46 pfam11788
39S mitochondrial ribosomal protein L46; This is the L46 subunit of the mammalian ...
 45-141 3.84e-18

39S mitochondrial ribosomal protein L46; This is the L46 subunit of the mammalian mitochondrial ribosome, conserved from plants and fungi.


:

Pssm-ID: 432074  Cd Length: 120  Bit Score: 77.97  E-value: 3.84e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26667177    45 WRLLGALCLQRPPVVSKPLTPLQEEM----ASLLQQIEIERSLYSDHELRALDEnQRLAKKKADLHDEEDEQD-----IL 115
Cdd:pfam11788   1 WKISVGLILSRPPVVTPEPSPFEKEYykyqEELLERLMWEFSRYFYFKKGTLAE-LRFKELQKKPIDRLEEIAfpigkPD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 26667177   116 LAQDLEDMWEQKFLQF---------------KLGARITEAD 141
Cdd:pfam11788  80 LRQDRERNDEQEIGLPksgleeseedverriKPAPRVTEAD 120
 
Name Accession Description Interval E-value
NUDIX_MRP_L46 cd04661
Mitochondrial ribosomal protein L46; Mitochondrial ribosomal protein L46 (MRP L46) is a ...
 136-275 1.87e-54

Mitochondrial ribosomal protein L46; Mitochondrial ribosomal protein L46 (MRP L46) is a component of the large subunit (39S) of the mammalian mitochondrial ribosome and a member of the NUDIX hydrolase superfamily. MRPs are thought to be involved in the maintenance of the mitochondrial DNA. In general, members of the NUDIX hydrolase superfamily require a divalent cation, such as Mg2+ or Mn2+, for activity and contain the NUDIX motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. MRP L46 appears to contain a modified NUDIX motif.


Pssm-ID: 467546  Cd Length: 142  Bit Score: 172.80  E-value: 1.87e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26667177 136 RITEADEKNDRTSLNRKLDRNLVLLVREKFGdQDVWILPQAEWQPGETLRGTAERTLATLSENNMEAKFLGNAPCGHYTF 215
Cdd:cd04661  10 RLPEADEKNDRKSLERKLDRTLYLLVKQKKG-KGPWQFPQGDVEEGETLREAAERGLRELGGDNMNTWFVGNAPIGVYKY 88

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 26667177 216 KFPQAMRTEsnlGAKVFFFKALLltgDFSQAGNKGHHVWVTKDELGDYLKPKYLAQVRRF 275
Cdd:cd04661  89 KYPKKTKEF---GYKSFFLKGRF---MPGQKKGVSDFAWLTKEELKEYVDPEYWKSVKKM 142
MRP-L46 pfam11788
39S mitochondrial ribosomal protein L46; This is the L46 subunit of the mammalian ...
 45-141 3.84e-18

39S mitochondrial ribosomal protein L46; This is the L46 subunit of the mammalian mitochondrial ribosome, conserved from plants and fungi.


Pssm-ID: 432074  Cd Length: 120  Bit Score: 77.97  E-value: 3.84e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26667177    45 WRLLGALCLQRPPVVSKPLTPLQEEM----ASLLQQIEIERSLYSDHELRALDEnQRLAKKKADLHDEEDEQD-----IL 115
Cdd:pfam11788   1 WKISVGLILSRPPVVTPEPSPFEKEYykyqEELLERLMWEFSRYFYFKKGTLAE-LRFKELQKKPIDRLEEIAfpigkPD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 26667177   116 LAQDLEDMWEQKFLQF---------------KLGARITEAD 141
Cdd:pfam11788  80 LRQDRERNDEQEIGLPksgleeseedverriKPAPRVTEAD 120
 
Name Accession Description Interval E-value
NUDIX_MRP_L46 cd04661
Mitochondrial ribosomal protein L46; Mitochondrial ribosomal protein L46 (MRP L46) is a ...
 136-275 1.87e-54

Mitochondrial ribosomal protein L46; Mitochondrial ribosomal protein L46 (MRP L46) is a component of the large subunit (39S) of the mammalian mitochondrial ribosome and a member of the NUDIX hydrolase superfamily. MRPs are thought to be involved in the maintenance of the mitochondrial DNA. In general, members of the NUDIX hydrolase superfamily require a divalent cation, such as Mg2+ or Mn2+, for activity and contain the NUDIX motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. MRP L46 appears to contain a modified NUDIX motif.


Pssm-ID: 467546  Cd Length: 142  Bit Score: 172.80  E-value: 1.87e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26667177 136 RITEADEKNDRTSLNRKLDRNLVLLVREKFGdQDVWILPQAEWQPGETLRGTAERTLATLSENNMEAKFLGNAPCGHYTF 215
Cdd:cd04661  10 RLPEADEKNDRKSLERKLDRTLYLLVKQKKG-KGPWQFPQGDVEEGETLREAAERGLRELGGDNMNTWFVGNAPIGVYKY 88

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 26667177 216 KFPQAMRTEsnlGAKVFFFKALLltgDFSQAGNKGHHVWVTKDELGDYLKPKYLAQVRRF 275
Cdd:cd04661  89 KYPKKTKEF---GYKSFFLKGRF---MPGQKKGVSDFAWLTKEELKEYVDPEYWKSVKKM 142
MRP-L46 pfam11788
39S mitochondrial ribosomal protein L46; This is the L46 subunit of the mammalian ...
 45-141 3.84e-18

39S mitochondrial ribosomal protein L46; This is the L46 subunit of the mammalian mitochondrial ribosome, conserved from plants and fungi.


Pssm-ID: 432074  Cd Length: 120  Bit Score: 77.97  E-value: 3.84e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26667177    45 WRLLGALCLQRPPVVSKPLTPLQEEM----ASLLQQIEIERSLYSDHELRALDEnQRLAKKKADLHDEEDEQD-----IL 115
Cdd:pfam11788   1 WKISVGLILSRPPVVTPEPSPFEKEYykyqEELLERLMWEFSRYFYFKKGTLAE-LRFKELQKKPIDRLEEIAfpigkPD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 26667177   116 LAQDLEDMWEQKFLQF---------------KLGARITEAD 141
Cdd:pfam11788  80 LRQDRERNDEQEIGLPksgleeseedverriKPAPRVTEAD 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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