NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1941084154|ref|NP_071593|]
View 

mannan-binding lectin serine protease 1 precursor [Rattus norvegicus]

Protein Classification

CUB and Tryp_SPc domain-containing protein( domain architecture ID 12870333)

protein containing domains EGF_CA, CUB, CCP, and Tryp_SPc

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 454-699 3.11e-86

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


:

Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 270.69  E-value: 3.11e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 454 IFNGRPAQKGTTPWIAMLSQLNGQPFCGGSLLGSNWVLTAAHCLHHPldpeepilhnshllSPSDFKIIMGKHWRRRSDE 533
Cdd:cd00190     1 IVGGSEAKIGSFPWQVSLQYTGGRHFCGGSLISPRWVLTAAHCVYSS--------------APSNYTVRLGSHDLSSNEG 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 534 DEQHLHVKHIMLHPLYNPSTFENDLGLVELSESPRLNDFVMPVCLPEHPS--TEGTMVIVSGWGK-QFLQRLPENLMEIE 610
Cdd:cd00190    67 GGQVIKVKKVIVHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYnlPAGTTCTVSGWGRtSEGGPLPDVLQEVN 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 611 IPIVNYHTCQEAYtPLGKKVTQDMICAGEKEGGKDACAGDSGGPMVTKDaeRDQWYLVGVVSWGEDCGKKDRYGVYSYIY 690
Cdd:cd00190   147 VPIVSNAECKRAY-SYGGTITDNMLCAGGLEGGKDACQGDSGGPLVCND--NGRGVLVGIVSWGSGCARPNYPGVYTRVS 223


                  ....*....
gi 1941084154 691 PNKDWIQRV 699
Cdd:cd00190   224 SYLDWIQKT 232
CUB pfam00431
CUB domain;
190-299 1.60e-36

CUB domain;


:

Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 132.80  E-value: 1.60e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 190 CSGNlFTQRTGTITSPDYPNPYPKSSECSYTIDLEEGFMVTLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFC 265
Cdd:pfam00431   1 CGGV-LTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRDGpsasSPLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1941084154 266 GEKSPEPISTQSHSIQILFRSDNSGENRGWRLSY 299
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 33-142 4.56e-30

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 114.43  E-value: 4.56e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154  33 FGQIQSPGYPDSYPSDSEVTWNITVPEGFRVQLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGRETTdteqtpg 108
Cdd:cd00041    10 SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgpSTSSPLLGRFCGSTLP------- 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1941084154 109 qEVVLSPGSFMSVTFRSDFSNeeRFTGFDAHYMA 142
Cdd:cd00041    83 -PPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 306-368 3.43e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 55.93  E-value: 3.43e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1941084154 306 CPKLQPPVYGKIEPSQAVYSFKDQVLISCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTCK 368
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSST------ITCTENGGWSPPPPTCE 57
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 158-186 1.86e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.32  E-value: 1.86e-08
                          10        20
                  ....*....|....*....|....*....
gi 1941084154 158 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 186
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
PHA02639 super family cl31493
EEV host range protein; Provisional
 305-438 1.96e-06

EEV host range protein; Provisional


The actual alignment was detected with superfamily member PHA02639:

Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 50.05  E-value: 1.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 305 ECPKLQPPVYGKIEPSQAVYSFKDQVLISCDTGYKV---LKDNEvmdtfQIECLKDGAWSNKIPTCKIVDCGVPAvLKHG 381
Cdd:PHA02639   84 ECNDPPSIINGKIYNKREMYKVGDEIYYVCNEHKGVqysLVGNE-----KITCIQDKSWKPDPPICKMINCRFPA-LQNG 157

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1941084154 382 LVTFSTRNNLTTYKSEIRYSCQQPYYKMLHNTTgvyTCSAHGTWTNevlkrSLPTCL 438
Cdd:PHA02639  158 YINGIPSNKKFYYKTRVGFSCKSGFDLVGEKYS---TCNINATWFP-----SIPTCV 206
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 454-699 3.11e-86

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 270.69  E-value: 3.11e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 454 IFNGRPAQKGTTPWIAMLSQLNGQPFCGGSLLGSNWVLTAAHCLHHPldpeepilhnshllSPSDFKIIMGKHWRRRSDE 533
Cdd:cd00190     1 IVGGSEAKIGSFPWQVSLQYTGGRHFCGGSLISPRWVLTAAHCVYSS--------------APSNYTVRLGSHDLSSNEG 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 534 DEQHLHVKHIMLHPLYNPSTFENDLGLVELSESPRLNDFVMPVCLPEHPS--TEGTMVIVSGWGK-QFLQRLPENLMEIE 610
Cdd:cd00190    67 GGQVIKVKKVIVHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYnlPAGTTCTVSGWGRtSEGGPLPDVLQEVN 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 611 IPIVNYHTCQEAYtPLGKKVTQDMICAGEKEGGKDACAGDSGGPMVTKDaeRDQWYLVGVVSWGEDCGKKDRYGVYSYIY 690
Cdd:cd00190   147 VPIVSNAECKRAY-SYGGTITDNMLCAGGLEGGKDACQGDSGGPLVCND--NGRGVLVGIVSWGSGCARPNYPGVYTRVS 223


                  ....*....
gi 1941084154 691 PNKDWIQRV 699
Cdd:cd00190   224 SYLDWIQKT 232
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 453-696 6.58e-84

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 264.54  E-value: 6.58e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154  453 RIFNGRPAQKGTTPWIAMLSQLNGQPFCGGSLLGSNWVLTAAHCLHHPldpeepilhnshllSPSDFKIIMGKHwRRRSD 532
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQYGGGRHFCGGSLISPRWVLTAAHCVRGS--------------DPSNIRVRLGSH-DLSSG 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154  533 EDEQHLHVKHIMLHPLYNPSTFENDLGLVELSESPRLNDFVMPVCLPEHPST--EGTMVIVSGWGKQFL--QRLPENLME 608
Cdd:smart00020  66 EEGQVIKVSKVIIHPNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSNYNvpAGTTCTVSGWGRTSEgaGSLPDTLQE 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154  609 IEIPIVNYHTCQEAYtPLGKKVTQDMICAGEKEGGKDACAGDSGGPMVTKDaerDQWYLVGVVSWGEDCGKKDRYGVYSY 688
Cdd:smart00020 146 VNVPIVSNATCRRAY-SGGGAITDNMLCAGGLEGGKDACQGDSGGPLVCND---GRWVLVGIVSWGSGCARPGKPGVYTR 221


                   ....*...
gi 1941084154  689 IYPNKDWI 696
Cdd:smart00020 222 VSSYLDWI 229
Trypsin pfam00089
Trypsin;
454-696 3.79e-76

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 243.89  E-value: 3.79e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 454 IFNGRPAQKGTTPWIAMLSQLNGQPFCGGSLLGSNWVLTAAHCLHhpldpeepilhnshllSPSDFKIIMGKHWRRRSDE 533
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQLSSGKHFCGGSLISENWVLTAAHCVS----------------GASDVKVVLGAHNIVLREG 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 534 DEQHLHVKHIMLHPLYNPSTFENDLGLVELSESPRLNDFVMPVCLPEHPST--EGTMVIVSGWGKQFLQRLPENLMEIEI 611
Cdd:pfam00089  65 GEQKFDVEKIIVHPNYNPDTLDNDIALLKLESPVTLGDTVRPICLPDASSDlpVGTTCTVSGWGNTKTLGPSDTLQEVTV 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 612 PIVNYHTCQEAYtplGKKVTQDMICAGekEGGKDACAGDSGGPMVTKDAerdqwYLVGVVSWGEDCGKKDRYGVYSYIYP 691
Cdd:pfam00089 145 PVVSRETCRSAY---GGTVTDTMICAG--AGGKDACQGDSGGPLVCSDG-----ELIGIVSWGYGCASGNYPGVYTPVSS 214


                  ....*
gi 1941084154 692 NKDWI 696
Cdd:pfam00089 215 YLDWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 452-702 3.17e-61

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 206.04  E-value: 3.17e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 452 SRIFNGRPAQKGTTPWIAMLSQLNG--QPFCGGSLLGSNWVLTAAHCLHHPldpeepilhnshllSPSDFKIIMGKHwrR 529
Cdd:COG5640    29 PAIVGGTPATVGEYPWMVALQSSNGpsGQFCGGTLIAPRWVLTAAHCVDGD--------------GPSDLRVVIGST--D 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 530 RSDEDEQHLHVKHIMLHPLYNPSTFENDLGLVELSESPrlnDFVMPVCLP--EHPSTEGTMVIVSGWGK--QFLQRLPEN 605
Cdd:COG5640    93 LSTSGGTVVKVARIVVHPDYDPATPGNDIALLKLATPV---PGVAPAPLAtsADAAAPGTPATVAGWGRtsEGPGSQSGT 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 606 LMEIEIPIVNYHTCQeAYtplGKKVTQDMICAGEKEGGKDACAGDSGGPMVTKDAerDQWYLVGVVSWGEDCGKKDRYGV 685
Cdd:COG5640   170 LRKADVPVVSDATCA-AY---GGFDGGTMLCAGYPEGGKDACQGDSGGPLVVKDG--GGWVLVGVVSWGGGPCAAGYPGV 243

                         250
                  ....*....|....*..
gi 1941084154 686 YSYIYPNKDWIQRVTGV 702
Cdd:COG5640   244 YTRVSAYRDWIKSTAGG 260
CUB pfam00431
CUB domain;
190-299 1.60e-36

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 132.80  E-value: 1.60e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 190 CSGNlFTQRTGTITSPDYPNPYPKSSECSYTIDLEEGFMVTLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFC 265
Cdd:pfam00431   1 CGGV-LTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRDGpsasSPLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1941084154 266 GEKSPEPISTQSHSIQILFRSDNSGENRGWRLSY 299
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 190-301 7.08e-35

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 128.30  E-value: 7.08e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 190 CSGNLFTQRTGTITSPDYPNPYPKSSECSYTIDLEEGFMVTLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFC 265
Cdd:cd00041     1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPN--CSYDYLEIYDGpstsSPLLGRFC 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1941084154 266 GEKSPEPISTQSHSIQILFRSDNSGENRGWRLSYRA 301
Cdd:cd00041    78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 33-142 4.56e-30

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 114.43  E-value: 4.56e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154  33 FGQIQSPGYPDSYPSDSEVTWNITVPEGFRVQLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGRETTdteqtpg 108
Cdd:cd00041    10 SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgpSTSSPLLGRFCGSTLP------- 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1941084154 109 qEVVLSPGSFMSVTFRSDFSNeeRFTGFDAHYMA 142
Cdd:cd00041    83 -PPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 200-299 8.94e-30

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 113.25  E-value: 8.94e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154  200 GTITSPDYPNPYPKSSECSYTIDLEEGFMVTLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFCGEKSPEP-IS 274
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDN--CEYDYVEIYDGpsasSPLLGRFCGSEAPPPvIS 77

                           90       100
                   ....*....|....*....|....*
gi 1941084154  275 TQSHSIQILFRSDNSGENRGWRLSY 299
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 34-140 1.43e-29

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 112.87  E-value: 1.43e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154   34 GQIQSPGYPDSYPSDSEVTWNITVPEGFRVQLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGREttdteqtPGQ 109
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIydgpSASSPLLGRFCGSE-------APP 73

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1941084154  110 EVVLSPGSFMSVTFRSDFSNEERftGFDAHY 140
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKR--GFSARY 102
CUB pfam00431
CUB domain;
28-140 3.06e-22

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 91.97  E-value: 3.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154  28 ELNEMFGQIQSPGYPDSYPSDSEVTWNITVPEGFRVQLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGREttdt 103
Cdd:pfam00431   4 VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIrdgpSASSPLLGRFCGSG---- 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1941084154 104 eqtpGQEVVLSPGSFMSVTFRSDFSNEERftGFDAHY 140
Cdd:pfam00431  80 ----IPEDIVSSSNQMTIKFVSDASVQKR--GFKATY 110
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 306-368 3.43e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 55.93  E-value: 3.43e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1941084154 306 CPKLQPPVYGKIEPSQAVYSFKDQVLISCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTCK 368
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSST------ITCTENGGWSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
306-367 8.58e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 54.81  E-value: 8.58e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1941084154 306 CPKLQPPVYGKIEPSQAVYSFKDQVLISCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTC 367
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPT------ITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 306-367 2.29e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 53.68  E-value: 2.29e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1941084154  306 CPKLQPPVYGKIEPSQAVYSFKDQVLISCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTC 367
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSST------ITCLENGTWSPPPPTC 56
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 158-186 1.86e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.32  E-value: 1.86e-08
                          10        20
                  ....*....|....*....|....*....
gi 1941084154 158 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 186
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
PHA02639 PHA02639
EEV host range protein; Provisional
 305-438 1.96e-06

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 50.05  E-value: 1.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 305 ECPKLQPPVYGKIEPSQAVYSFKDQVLISCDTGYKV---LKDNEvmdtfQIECLKDGAWSNKIPTCKIVDCGVPAvLKHG 381
Cdd:PHA02639   84 ECNDPPSIINGKIYNKREMYKVGDEIYYVCNEHKGVqysLVGNE-----KITCIQDKSWKPDPPICKMINCRFPA-LQNG 157

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1941084154 382 LVTFSTRNNLTTYKSEIRYSCQQPYYKMLHNTTgvyTCSAHGTWTNevlkrSLPTCL 438
Cdd:PHA02639  158 YINGIPSNKKFYYKTRVGFSCKSGFDLVGEKYS---TCNINATWFP-----SIPTCV 206
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 372-437 9.14e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.61  E-value: 9.14e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1941084154 372 CGVPAVLKHGLVTFSTRNnlTTYKSEIRYSCqQPYYKMLHNTTgvYTCSAHGTWTNEVlkrslPTC 437
Cdd:cd00033     1 CPPPPVPENGTVTGSKGS--YSYGSTVTYSC-NEGYTLVGSST--ITCTENGGWSPPP-----PTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
372-437 1.26e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 43.26  E-value: 1.26e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1941084154 372 CGVPAVLKHGLVtfSTRNNLTTYKSEIRYSCQQPYYKMLHNTTgvyTCSAHGTWTNEVlkrslPTC 437
Cdd:pfam00084   1 CPPPPDIPNGKV--SATKNEYNYGASVSYECDPGYRLVGSPTI---TCQEDGTWSPPF-----PEC 56
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 284-387 3.65e-05

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 46.23  E-value: 3.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 284 FRSDNSGENRGWRLSYRAAGNECPKLQPPvYGKIEPSQAVYSFKDQVLISCDTGYkvlkdnEVMDTFQIECLKDgAWsNK 363
Cdd:PHA02954  108 FRCEEKNGNTSWNDTVTCPNAECQPLQLE-HGSCQPVKEKYSFGEHITINCDVGY------EVIGASYISCTAN-SW-NV 178

                          90       100
                  ....*....|....*....|....
gi 1941084154 364 IPTCKiVDCGVPAvLKHGLVTFST 387
Cdd:PHA02954  179 IPSCQ-QKCDIPS-LSNGLISGST 200
EGF_CA smart00179
Calcium-binding EGF-like domain;
144-186 5.44e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 5.44e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1941084154  144 DVDECKEREDeelsCDH--YCHNYIGGYYCSCRFGYilhTDNRTC 186
Cdd:smart00179   1 DIDECASGNP----CQNggTCVNTVGSYRCECPPGY---TDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 144-181 2.12e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 2.12e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1941084154 144 DVDECKEREdeelSCDHY--CHNYIGGYYCSCRFGYILHT 181
Cdd:cd00054     1 DIDECASGN----PCQNGgtCVNTVGSYRCSCPPGYTGRN 36
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 372-437 4.31e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 38.66  E-value: 4.31e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1941084154  372 CGVPAVLKHGLVTFSTRNnlTTYKSEIRYSCQQPYYKMLHNTTgvyTCSAHGTWTNEVlkrslPTC 437
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT--YSYGDTVTYSCDPGYTLIGSSTI---TCLENGTWSPPP-----PTC 56
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 454-699 3.11e-86

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 270.69  E-value: 3.11e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 454 IFNGRPAQKGTTPWIAMLSQLNGQPFCGGSLLGSNWVLTAAHCLHHPldpeepilhnshllSPSDFKIIMGKHWRRRSDE 533
Cdd:cd00190     1 IVGGSEAKIGSFPWQVSLQYTGGRHFCGGSLISPRWVLTAAHCVYSS--------------APSNYTVRLGSHDLSSNEG 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 534 DEQHLHVKHIMLHPLYNPSTFENDLGLVELSESPRLNDFVMPVCLPEHPS--TEGTMVIVSGWGK-QFLQRLPENLMEIE 610
Cdd:cd00190    67 GGQVIKVKKVIVHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYnlPAGTTCTVSGWGRtSEGGPLPDVLQEVN 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 611 IPIVNYHTCQEAYtPLGKKVTQDMICAGEKEGGKDACAGDSGGPMVTKDaeRDQWYLVGVVSWGEDCGKKDRYGVYSYIY 690
Cdd:cd00190   147 VPIVSNAECKRAY-SYGGTITDNMLCAGGLEGGKDACQGDSGGPLVCND--NGRGVLVGIVSWGSGCARPNYPGVYTRVS 223


                  ....*....
gi 1941084154 691 PNKDWIQRV 699
Cdd:cd00190   224 SYLDWIQKT 232
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 453-696 6.58e-84

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 264.54  E-value: 6.58e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154  453 RIFNGRPAQKGTTPWIAMLSQLNGQPFCGGSLLGSNWVLTAAHCLHHPldpeepilhnshllSPSDFKIIMGKHwRRRSD 532
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQYGGGRHFCGGSLISPRWVLTAAHCVRGS--------------DPSNIRVRLGSH-DLSSG 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154  533 EDEQHLHVKHIMLHPLYNPSTFENDLGLVELSESPRLNDFVMPVCLPEHPST--EGTMVIVSGWGKQFL--QRLPENLME 608
Cdd:smart00020  66 EEGQVIKVSKVIIHPNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSNYNvpAGTTCTVSGWGRTSEgaGSLPDTLQE 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154  609 IEIPIVNYHTCQEAYtPLGKKVTQDMICAGEKEGGKDACAGDSGGPMVTKDaerDQWYLVGVVSWGEDCGKKDRYGVYSY 688
Cdd:smart00020 146 VNVPIVSNATCRRAY-SGGGAITDNMLCAGGLEGGKDACQGDSGGPLVCND---GRWVLVGIVSWGSGCARPGKPGVYTR 221


                   ....*...
gi 1941084154  689 IYPNKDWI 696
Cdd:smart00020 222 VSSYLDWI 229
Trypsin pfam00089
Trypsin;
454-696 3.79e-76

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 243.89  E-value: 3.79e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 454 IFNGRPAQKGTTPWIAMLSQLNGQPFCGGSLLGSNWVLTAAHCLHhpldpeepilhnshllSPSDFKIIMGKHWRRRSDE 533
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQLSSGKHFCGGSLISENWVLTAAHCVS----------------GASDVKVVLGAHNIVLREG 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 534 DEQHLHVKHIMLHPLYNPSTFENDLGLVELSESPRLNDFVMPVCLPEHPST--EGTMVIVSGWGKQFLQRLPENLMEIEI 611
Cdd:pfam00089  65 GEQKFDVEKIIVHPNYNPDTLDNDIALLKLESPVTLGDTVRPICLPDASSDlpVGTTCTVSGWGNTKTLGPSDTLQEVTV 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 612 PIVNYHTCQEAYtplGKKVTQDMICAGekEGGKDACAGDSGGPMVTKDAerdqwYLVGVVSWGEDCGKKDRYGVYSYIYP 691
Cdd:pfam00089 145 PVVSRETCRSAY---GGTVTDTMICAG--AGGKDACQGDSGGPLVCSDG-----ELIGIVSWGYGCASGNYPGVYTPVSS 214


                  ....*
gi 1941084154 692 NKDWI 696
Cdd:pfam00089 215 YLDWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 452-702 3.17e-61

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 206.04  E-value: 3.17e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 452 SRIFNGRPAQKGTTPWIAMLSQLNG--QPFCGGSLLGSNWVLTAAHCLHHPldpeepilhnshllSPSDFKIIMGKHwrR 529
Cdd:COG5640    29 PAIVGGTPATVGEYPWMVALQSSNGpsGQFCGGTLIAPRWVLTAAHCVDGD--------------GPSDLRVVIGST--D 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 530 RSDEDEQHLHVKHIMLHPLYNPSTFENDLGLVELSESPrlnDFVMPVCLP--EHPSTEGTMVIVSGWGK--QFLQRLPEN 605
Cdd:COG5640    93 LSTSGGTVVKVARIVVHPDYDPATPGNDIALLKLATPV---PGVAPAPLAtsADAAAPGTPATVAGWGRtsEGPGSQSGT 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 606 LMEIEIPIVNYHTCQeAYtplGKKVTQDMICAGEKEGGKDACAGDSGGPMVTKDAerDQWYLVGVVSWGEDCGKKDRYGV 685
Cdd:COG5640   170 LRKADVPVVSDATCA-AY---GGFDGGTMLCAGYPEGGKDACQGDSGGPLVVKDG--GGWVLVGVVSWGGGPCAAGYPGV 243

                         250
                  ....*....|....*..
gi 1941084154 686 YSYIYPNKDWIQRVTGV 702
Cdd:COG5640   244 YTRVSAYRDWIKSTAGG 260
CUB pfam00431
CUB domain;
190-299 1.60e-36

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 132.80  E-value: 1.60e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 190 CSGNlFTQRTGTITSPDYPNPYPKSSECSYTIDLEEGFMVTLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFC 265
Cdd:pfam00431   1 CGGV-LTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRDGpsasSPLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1941084154 266 GEKSPEPISTQSHSIQILFRSDNSGENRGWRLSY 299
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 190-301 7.08e-35

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 128.30  E-value: 7.08e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 190 CSGNLFTQRTGTITSPDYPNPYPKSSECSYTIDLEEGFMVTLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFC 265
Cdd:cd00041     1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPN--CSYDYLEIYDGpstsSPLLGRFC 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1941084154 266 GEKSPEPISTQSHSIQILFRSDNSGENRGWRLSYRA 301
Cdd:cd00041    78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 33-142 4.56e-30

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 114.43  E-value: 4.56e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154  33 FGQIQSPGYPDSYPSDSEVTWNITVPEGFRVQLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGRETTdteqtpg 108
Cdd:cd00041    10 SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgpSTSSPLLGRFCGSTLP------- 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1941084154 109 qEVVLSPGSFMSVTFRSDFSNeeRFTGFDAHYMA 142
Cdd:cd00041    83 -PPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 200-299 8.94e-30

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 113.25  E-value: 8.94e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154  200 GTITSPDYPNPYPKSSECSYTIDLEEGFMVTLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFCGEKSPEP-IS 274
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDN--CEYDYVEIYDGpsasSPLLGRFCGSEAPPPvIS 77

                           90       100
                   ....*....|....*....|....*
gi 1941084154  275 TQSHSIQILFRSDNSGENRGWRLSY 299
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 34-140 1.43e-29

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 112.87  E-value: 1.43e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154   34 GQIQSPGYPDSYPSDSEVTWNITVPEGFRVQLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGREttdteqtPGQ 109
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIydgpSASSPLLGRFCGSE-------APP 73

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1941084154  110 EVVLSPGSFMSVTFRSDFSNEERftGFDAHY 140
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKR--GFSARY 102
CUB pfam00431
CUB domain;
28-140 3.06e-22

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 91.97  E-value: 3.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154  28 ELNEMFGQIQSPGYPDSYPSDSEVTWNITVPEGFRVQLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGREttdt 103
Cdd:pfam00431   4 VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIrdgpSASSPLLGRFCGSG---- 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1941084154 104 eqtpGQEVVLSPGSFMSVTFRSDFSNEERftGFDAHY 140
Cdd:pfam00431  80 ----IPEDIVSSSNQMTIKFVSDASVQKR--GFKATY 110
eMpr COG3591
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, ...
 468-674 8.60e-12

V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442810 [Multi-domain]  Cd Length: 194  Bit Score: 64.70  E-value: 8.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 468 IAMLSQLNGQPFCGGSLLGSNWVLTAAHCLHHPLDPEepilhnshllSPSDFKIIMGkhwrrRSDEDEQHLHVKHIMLHP 547
Cdd:COG3591     2 VGRLETDGGGGVCTGTLIGPNLVLTAGHCVYDGAGGG----------WATNIVFVPG-----YNGGPYGTATATRFRVPP 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 548 LYNPST-FENDLGLVELSESPRLNDFVMPVCLPEHPSTEGTMVIVS-GWGKQFLQRLPEN--LMEIEIPIVnYHTCqeay 623
Cdd:COG3591    67 GWVASGdAGYDYALLRLDEPLGDTTGWLGLAFNDAPLAGEPVTIIGyPGDRPKDLSLDCSgrVTGVQGNRL-SYDC---- 141

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1941084154 624 tplgkkvtqdmicagekeggkDACAGDSGGPMVTKDAERdqWYLVGVVSWG 674
Cdd:COG3591   142 ---------------------DTTGGSSGSPVLDDSDGG--GRVVGVHSAG 169
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 306-368 3.43e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 55.93  E-value: 3.43e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1941084154 306 CPKLQPPVYGKIEPSQAVYSFKDQVLISCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTCK 368
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSST------ITCTENGGWSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
306-367 8.58e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 54.81  E-value: 8.58e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1941084154 306 CPKLQPPVYGKIEPSQAVYSFKDQVLISCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTC 367
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPT------ITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 306-367 2.29e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 53.68  E-value: 2.29e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1941084154  306 CPKLQPPVYGKIEPSQAVYSFKDQVLISCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTC 367
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSST------ITCLENGTWSPPPPTC 56
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 158-186 1.86e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.32  E-value: 1.86e-08
                          10        20
                  ....*....|....*....|....*....
gi 1941084154 158 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 186
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
PHA02639 PHA02639
EEV host range protein; Provisional
 305-438 1.96e-06

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 50.05  E-value: 1.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 305 ECPKLQPPVYGKIEPSQAVYSFKDQVLISCDTGYKV---LKDNEvmdtfQIECLKDGAWSNKIPTCKIVDCGVPAvLKHG 381
Cdd:PHA02639   84 ECNDPPSIINGKIYNKREMYKVGDEIYYVCNEHKGVqysLVGNE-----KITCIQDKSWKPDPPICKMINCRFPA-LQNG 157

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1941084154 382 LVTFSTRNNLTTYKSEIRYSCQQPYYKMLHNTTgvyTCSAHGTWTNevlkrSLPTCL 438
Cdd:PHA02639  158 YINGIPSNKKFYYKTRVGFSCKSGFDLVGEKYS---TCNINATWFP-----SIPTCV 206
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 372-437 9.14e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.61  E-value: 9.14e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1941084154 372 CGVPAVLKHGLVTFSTRNnlTTYKSEIRYSCqQPYYKMLHNTTgvYTCSAHGTWTNEVlkrslPTC 437
Cdd:cd00033     1 CPPPPVPENGTVTGSKGS--YSYGSTVTYSC-NEGYTLVGSST--ITCTENGGWSPPP-----PTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
372-437 1.26e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 43.26  E-value: 1.26e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1941084154 372 CGVPAVLKHGLVtfSTRNNLTTYKSEIRYSCQQPYYKMLHNTTgvyTCSAHGTWTNEVlkrslPTC 437
Cdd:pfam00084   1 CPPPPDIPNGKV--SATKNEYNYGASVSYECDPGYRLVGSPTI---TCQEDGTWSPPF-----PEC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 311-437 2.61e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 46.09  E-value: 2.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 311 PP--VYGKIEPSQAVYSFKDQVLISCDTGYKVLKDNEVMDTfQIECLKDGAWSNKIPTCKIVDCGVPAvLKHGLVTFSTR 388
Cdd:PHA02817   27 PPsiKNGYIYNKKTEYNIGSNVTFFCGNNTRGVRYTLVGEK-NIICEKDGKWNKEFPVCKIIRCRFPA-LQNGFVNGIPD 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1941084154 389 NNLTTYKSEIRYSCQQPYykmLHNTTGVYTCSAHGTWTNEVlkrslPTC 437
Cdd:PHA02817  105 SKKFYYESEVSFSCKPGF---VLIGTKYSVCGINSSWIPKV-----PIC 145
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 284-387 3.65e-05

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 46.23  E-value: 3.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 284 FRSDNSGENRGWRLSYRAAGNECPKLQPPvYGKIEPSQAVYSFKDQVLISCDTGYkvlkdnEVMDTFQIECLKDgAWsNK 363
Cdd:PHA02954  108 FRCEEKNGNTSWNDTVTCPNAECQPLQLE-HGSCQPVKEKYSFGEHITINCDVGY------EVIGASYISCTAN-SW-NV 178

                          90       100
                  ....*....|....*....|....
gi 1941084154 364 IPTCKiVDCGVPAvLKHGLVTFST 387
Cdd:PHA02954  179 IPSCQ-QKCDIPS-LSNGLISGST 200
EGF_CA smart00179
Calcium-binding EGF-like domain;
144-186 5.44e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 5.44e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1941084154  144 DVDECKEREDeelsCDH--YCHNYIGGYYCSCRFGYilhTDNRTC 186
Cdd:smart00179   1 DIDECASGNP----CQNggTCVNTVGSYRCECPPGY---TDGRNC 38
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 294-455 1.55e-04

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 44.26  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 294 GWRLSYRAAGNECPKLQPPVYGKIEPSQAvySFKDQVLISCDTGYKVLkdNEVMDTFQIECLKDGAWSNKIPTCKIVDCG 373
Cdd:PHA02927   74 GWTLFNQCIKRRCPSPRDIDNGQLDIGGV--DFGSSITYSCNSGYQLI--GESKSYCELGSTGSMVWNPEAPICESVKCQ 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941084154 374 VPAVLKHGlvTFSTRNNLTTYKSEIRYSCQQPYykMLHNTTGVyTCSAhGTWTNEvlkrslPTCLPV-CGLPKFSRKHIS 452
Cdd:PHA02927  150 SPPSISNG--RHNGYEDFYTDGSVVTYSCNSGY--SLIGNSGV-LCSG-GEWSDP------PTCQIVkCPHPTISNGYLS 217


                  ...
gi 1941084154 453 RIF 455
Cdd:PHA02927  218 SGF 220
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 144-181 2.12e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 2.12e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1941084154 144 DVDECKEREdeelSCDHY--CHNYIGGYYCSCRFGYILHT 181
Cdd:cd00054     1 DIDECASGN----PCQNGgtCVNTVGSYRCSCPPGYTGRN 36
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 372-437 4.31e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 38.66  E-value: 4.31e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1941084154  372 CGVPAVLKHGLVTFSTRNnlTTYKSEIRYSCQQPYYKMLHNTTgvyTCSAHGTWTNEVlkrslPTC 437
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT--YSYGDTVTYSCDPGYTLIGSSTI---TCLENGTWSPPP-----PTC 56
EGF_CA pfam07645
Calcium-binding EGF domain;
144-176 4.92e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 34.91  E-value: 4.92e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1941084154 144 DVDECkerEDEELSCDH--YCHNYIGGYYCSCRFG 176
Cdd:pfam07645   1 DVDEC---ATGTHNCPAntVCVNTIGSFECRCPDG 32
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 121-185 5.93e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 38.91  E-value: 5.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1941084154 121 VTFRSDFSNEERFTGFDAHYMAVDVDECKEredEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 185
Cdd:cd01475   163 VFYVEDFSTIEELTKKFQGKICVVPDLCAT---LSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH