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Conserved domains on  [gi|12232479|ref|NP_073623|]
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protein ARV1 isoform 2 [Homo sapiens]

Protein Classification

ARV1 family protein( domain architecture ID 10514454)

ARV1 (ARE2 required for viability) family protein functions as a mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes, and also regulates sphingolipid metabolism

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arv1 pfam04161
Arv1-like family; Arv1 is a transmembrane protein with potential zinc-binding motifs. ARV1 is ...
 33-223 1.46e-69

Arv1-like family; Arv1 is a transmembrane protein with potential zinc-binding motifs. ARV1 is a novel mediator of eukaryotic sterol homeostasis.


:

Pssm-ID: 461202  Cd Length: 204  Bit Score: 213.26  E-value: 1.46e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12232479    33 RCIECNQEAKELYRDYNHGVLKITICKSCQKPVDKYIEYDPVIILINAILCKAQAYRHILFNT---------QINIHGKL 103
Cdd:pfam04161   1 ICIECGHPVKSLYTQYSNGNIRLTICPNCKKVADKYIEFDFVILFIDLLLLKPQAYRHLLFNSlerelnwflKYRSLWRL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12232479   104 CIFCLLCEAYLRWWQL----QDSNQNTAPDDLIRYAKEWDFYRMFAI-AALEQTAYFIGIFTFLWVERPMTAkKKPNFIL 178
Cdd:pfam04161  81 WLLLLLFEVYLTWAREekdtSGSSSLSISAIVLLSLKPLDQYLFFLLlCLLETVVFHLSILLLLRLLSWFGW-FKYRPNA 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 12232479   179 LLKALLLSSYGKLLLIPAVIWEHDYTSVCLKLIKVFVLTSNFQAI 223
Cdd:pfam04161 160 LSLALLLSSYAKLFPILMLIWPYDPPSLSTFIIKWLVLLSNVEAL 204
 
Name Accession Description Interval E-value
Arv1 pfam04161
Arv1-like family; Arv1 is a transmembrane protein with potential zinc-binding motifs. ARV1 is ...
 33-223 1.46e-69

Arv1-like family; Arv1 is a transmembrane protein with potential zinc-binding motifs. ARV1 is a novel mediator of eukaryotic sterol homeostasis.


Pssm-ID: 461202  Cd Length: 204  Bit Score: 213.26  E-value: 1.46e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12232479    33 RCIECNQEAKELYRDYNHGVLKITICKSCQKPVDKYIEYDPVIILINAILCKAQAYRHILFNT---------QINIHGKL 103
Cdd:pfam04161   1 ICIECGHPVKSLYTQYSNGNIRLTICPNCKKVADKYIEFDFVILFIDLLLLKPQAYRHLLFNSlerelnwflKYRSLWRL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12232479   104 CIFCLLCEAYLRWWQL----QDSNQNTAPDDLIRYAKEWDFYRMFAI-AALEQTAYFIGIFTFLWVERPMTAkKKPNFIL 178
Cdd:pfam04161  81 WLLLLLFEVYLTWAREekdtSGSSSLSISAIVLLSLKPLDQYLFFLLlCLLETVVFHLSILLLLRLLSWFGW-FKYRPNA 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 12232479   179 LLKALLLSSYGKLLLIPAVIWEHDYTSVCLKLIKVFVLTSNFQAI 223
Cdd:pfam04161 160 LSLALLLSSYAKLFPILMLIWPYDPPSLSTFIIKWLVLLSNVEAL 204
ARV1 COG5254
Predicted membrane protein [Function unknown];
32-240 1.03e-14

Predicted membrane protein [Function unknown];


Pssm-ID: 227579  Cd Length: 239  Bit Score: 71.47  E-value: 1.03e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12232479  32 YRCIECNQEAKELYRDYNHGVLKITICKSCQKPVDKYIEYDPVIILINAILCKAQAYRHILFNT-QINIHGKLC------ 104
Cdd:COG5254   1 MVCIECGSRVDSLYTRYSTSAIQLSRCPSCNRKMDKYFELDGVLKLIDLLLLKRRIYRHLLFNSlRARTFTNDVlcmlav 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12232479 105 -IFC-------LLCEAYLRWWQLQDSNQN---TAPDDLIRYAKE---------WDFYRMFAIAALEQTAYFiGIFTFLWV 164
Cdd:COG5254  81 rMFCepilqlhEAFGLLLSWGPGEGVSIAemaTICRDVPESLMEtslilrlvfSMQYLHAGFVCLSSALLL-SSFYYLFM 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12232479 165 ERPMTAKKKPnfILLLKALLLSSYGKLLLIPAVIWEHDyTSVCLKLIKVFVLTSNFQAIRVTLNINRKLSFLAVLS 240
Cdd:COG5254 160 FIMTMWKYQC--EESLLVIELSCVACNSPVIMEIWLYD-NEIALGCIYWVKFAAGLVCLRILTTIRLNFFLSGCST 232
 
Name Accession Description Interval E-value
Arv1 pfam04161
Arv1-like family; Arv1 is a transmembrane protein with potential zinc-binding motifs. ARV1 is ...
 33-223 1.46e-69

Arv1-like family; Arv1 is a transmembrane protein with potential zinc-binding motifs. ARV1 is a novel mediator of eukaryotic sterol homeostasis.


Pssm-ID: 461202  Cd Length: 204  Bit Score: 213.26  E-value: 1.46e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12232479    33 RCIECNQEAKELYRDYNHGVLKITICKSCQKPVDKYIEYDPVIILINAILCKAQAYRHILFNT---------QINIHGKL 103
Cdd:pfam04161   1 ICIECGHPVKSLYTQYSNGNIRLTICPNCKKVADKYIEFDFVILFIDLLLLKPQAYRHLLFNSlerelnwflKYRSLWRL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12232479   104 CIFCLLCEAYLRWWQL----QDSNQNTAPDDLIRYAKEWDFYRMFAI-AALEQTAYFIGIFTFLWVERPMTAkKKPNFIL 178
Cdd:pfam04161  81 WLLLLLFEVYLTWAREekdtSGSSSLSISAIVLLSLKPLDQYLFFLLlCLLETVVFHLSILLLLRLLSWFGW-FKYRPNA 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 12232479   179 LLKALLLSSYGKLLLIPAVIWEHDYTSVCLKLIKVFVLTSNFQAI 223
Cdd:pfam04161 160 LSLALLLSSYAKLFPILMLIWPYDPPSLSTFIIKWLVLLSNVEAL 204
ARV1 COG5254
Predicted membrane protein [Function unknown];
32-240 1.03e-14

Predicted membrane protein [Function unknown];


Pssm-ID: 227579  Cd Length: 239  Bit Score: 71.47  E-value: 1.03e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12232479  32 YRCIECNQEAKELYRDYNHGVLKITICKSCQKPVDKYIEYDPVIILINAILCKAQAYRHILFNT-QINIHGKLC------ 104
Cdd:COG5254   1 MVCIECGSRVDSLYTRYSTSAIQLSRCPSCNRKMDKYFELDGVLKLIDLLLLKRRIYRHLLFNSlRARTFTNDVlcmlav 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12232479 105 -IFC-------LLCEAYLRWWQLQDSNQN---TAPDDLIRYAKE---------WDFYRMFAIAALEQTAYFiGIFTFLWV 164
Cdd:COG5254  81 rMFCepilqlhEAFGLLLSWGPGEGVSIAemaTICRDVPESLMEtslilrlvfSMQYLHAGFVCLSSALLL-SSFYYLFM 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12232479 165 ERPMTAKKKPnfILLLKALLLSSYGKLLLIPAVIWEHDyTSVCLKLIKVFVLTSNFQAIRVTLNINRKLSFLAVLS 240
Cdd:COG5254 160 FIMTMWKYQC--EESLLVIELSCVACNSPVIMEIWLYD-NEIALGCIYWVKFAAGLVCLRILTTIRLNFFLSGCST 232
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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