NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|23503235|ref|NP_076414|]
View 

caprin-2 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Caprin-1_C pfam12287
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ...
620-885 1.03e-141

Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.


:

Pssm-ID: 463522 [Multi-domain]  Cd Length: 320  Bit Score: 428.06  E-value: 1.03e-141
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    620 LQDLMTQIQGTCNFMQESVLDFDKPS-SAIPTSQPPSATP-----GSPVASKEQNLSSQSDFLQEPLQATSSPVTCSSNA 693
Cdd:pfam12287    1 LQDLMAQIQGTYNFMQDSMLDFDKPSdSAIVSAQPPSQSPdlsqmVCPPASPEQRLSQQSDVLQQPEQTQVSPVSPSSNA 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    694 ClvttdqASSGSETEFMTSETPE-------------------------------------------------------VF 718
Cdd:pfam12287   81 C------ASSGSEYQFHTSEPPQpeaidpiqssmslpselappspplspasqpqvfqskpasssginvnaapfqsmqtVF 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    719 NVNAPLPPRKEQEIKE-SPYSPGYNQSFTTASTQTPPQCQLPSIHVEQTVhsqeTANYHPDGTIQVSNGSLAFYPAQTNV 797
Cdd:pfam12287  155 NVNAPVPPRNEQELKEsSQYSSGYNQSFSSQSTQTVPQCQLPSEQLEQTV----VGAYHPDGTIQVSNGHLAFYPAQTNG 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    798 FPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYK-GFDTYRG-LPSISNGNYSQLQFQAREYSGAPYSQRDNFQQCYK 875
Cdd:pfam12287  231 FPRPPQPFYNSRGSPRGGPRGGRGLMNGYRGPNGFKgGFDGYRGpFPNTPNGGYGQLQFQARDYSGTPYSQRDGYQQNYK 310
                          330
                   ....*....|
gi 23503235    876 RGGTSGGPRA 885
Cdd:pfam12287  311 RGGTQSGPRA 320
Caprin-1_dimer pfam18293
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a ...
200-315 4.49e-51

Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a role in many important biological processes, including cellular proliferation, innate immune response and synaptic plasticity. This domain is found in the highly conserved homologous region 1(HR1) and is responsible for the tight homodimerization of Caprin-1.


:

Pssm-ID: 436391  Cd Length: 116  Bit Score: 175.09  E-value: 4.49e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    200 RREHMLKLEAEKKKLRTILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKELDYLIKFSKLTCPERNESLSVEDQMEQSS 279
Cdd:pfam18293    1 KKEAQLKMQAELARLREVLQVQDVLNSLGSEDVRNDFLNGTNGAVKLTEEDLKQLDEFYKLVGPKRDEDTSFADQMQKAA 80
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 23503235    280 LYFWDLLEGSEKAVVGTTYKHLKDLLSKLLNSGYFE 315
Cdd:pfam18293   81 EHLWALLEGKEKPVAGTTYKELKELLDKILNCGYFD 116
C1q pfam00386
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ...
949-1074 6.29e-41

C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.


:

Pssm-ID: 395310 [Multi-domain]  Cd Length: 126  Bit Score: 146.66  E-value: 6.29e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    949 AFSAARTSNLAPGTlDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAvNVPLYVNLMKNEEVLVSAYAND 1028
Cdd:pfam00386    1 AFSAGRTTGLTAPN-EQPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITTVD-GKSLYVSLVKNGQEVVSFYDQP 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 23503235   1029 GAPDHETASNHAILQLFQGDQIWLRLH--RGAIYGSSWKYSTFSGYLL 1074
Cdd:pfam00386   79 QKGSLDVASGSVVLELQRGDEVWLQLTgyNGLYYDGSDTDSTFSGFLL 126
SCP-1 super family cl30946
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
88-510 1.60e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


The actual alignment was detected with superfamily member pfam05483:

Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 48.95  E-value: 1.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235     88 QVNHSQHGESQRaLSPLQSTLSSAASPSQAYEtyiENGLICLKHKIRNIEKKKLKLEDyKDRLKSGEHLNPDQLEA-VEK 166
Cdd:pfam05483  286 ELIEKKDHLTKE-LEDIKMSLQRSMSTQKALE---EDLQIATKTICQLTEEKEAQMEE-LNKAKAAHSFVVTEFEAtTCS 360
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    167 YEEVLHNLEfaKELQKTFSGLSLDLLKAQKKAQRREHMLKL----EAEKKKLRTILQVQYVL--QNLTQEHVQKDFKGG- 239
Cdd:pfam05483  361 LEELLRTEQ--QRLEKNEDQLKIITMELQKKSSELEEMTKFknnkEVELEELKKILAEDEKLldEKKQFEKIAEELKGKe 438
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    240 --LNGAVYLPSKEL-DYLIKFSKLTCPERNESLSVED---QMEQSSLYFWDLLEGSEKAVVGTT--YKHLKDLLSKLLNS 311
Cdd:pfam05483  439 qeLIFLLQAREKEIhDLEIQLTAIKTSEEHYLKEVEDlktELEKEKLKNIELTAHCDKLLLENKelTQEASDMTLELKKH 518
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    312 GyfESIpvpKNAKEKEVPLEEEMLIQSEKKTQL-SKTESVKEseslmEFAQP------EIQPQEFLNRRYMTEVDYSNKQ 384
Cdd:pfam05483  519 Q--EDI---INCKKQEERMLKQIENLEEKEMNLrDELESVRE-----EFIQKgdevkcKLDKSEENARSIEYEVLKKEKQ 588
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    385 GEEQPWEADYARK--PNLPKRWDMLTEPDGQEKKQESFKSWEASGKHQEVSKPAVSLEQRKQDTSKLRSTLPEEQKKQEI 462
Cdd:pfam05483  589 MKILENKCNNLKKqiENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKI 668
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*...
gi 23503235    463 SKSKpspsqwkqdtpkskagyVQEEQKKQETPKLWPVQLQKEQDPKKQ 510
Cdd:pfam05483  669 SEEK-----------------LLEEVEKAKAIADEAVKLQKEIDKRCQ 699
 
Name Accession Description Interval E-value
Caprin-1_C pfam12287
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ...
620-885 1.03e-141

Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.


Pssm-ID: 463522 [Multi-domain]  Cd Length: 320  Bit Score: 428.06  E-value: 1.03e-141
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    620 LQDLMTQIQGTCNFMQESVLDFDKPS-SAIPTSQPPSATP-----GSPVASKEQNLSSQSDFLQEPLQATSSPVTCSSNA 693
Cdd:pfam12287    1 LQDLMAQIQGTYNFMQDSMLDFDKPSdSAIVSAQPPSQSPdlsqmVCPPASPEQRLSQQSDVLQQPEQTQVSPVSPSSNA 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    694 ClvttdqASSGSETEFMTSETPE-------------------------------------------------------VF 718
Cdd:pfam12287   81 C------ASSGSEYQFHTSEPPQpeaidpiqssmslpselappspplspasqpqvfqskpasssginvnaapfqsmqtVF 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    719 NVNAPLPPRKEQEIKE-SPYSPGYNQSFTTASTQTPPQCQLPSIHVEQTVhsqeTANYHPDGTIQVSNGSLAFYPAQTNV 797
Cdd:pfam12287  155 NVNAPVPPRNEQELKEsSQYSSGYNQSFSSQSTQTVPQCQLPSEQLEQTV----VGAYHPDGTIQVSNGHLAFYPAQTNG 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    798 FPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYK-GFDTYRG-LPSISNGNYSQLQFQAREYSGAPYSQRDNFQQCYK 875
Cdd:pfam12287  231 FPRPPQPFYNSRGSPRGGPRGGRGLMNGYRGPNGFKgGFDGYRGpFPNTPNGGYGQLQFQARDYSGTPYSQRDGYQQNYK 310
                          330
                   ....*....|
gi 23503235    876 RGGTSGGPRA 885
Cdd:pfam12287  311 RGGTQSGPRA 320
Caprin-1_dimer pfam18293
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a ...
200-315 4.49e-51

Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a role in many important biological processes, including cellular proliferation, innate immune response and synaptic plasticity. This domain is found in the highly conserved homologous region 1(HR1) and is responsible for the tight homodimerization of Caprin-1.


Pssm-ID: 436391  Cd Length: 116  Bit Score: 175.09  E-value: 4.49e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    200 RREHMLKLEAEKKKLRTILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKELDYLIKFSKLTCPERNESLSVEDQMEQSS 279
Cdd:pfam18293    1 KKEAQLKMQAELARLREVLQVQDVLNSLGSEDVRNDFLNGTNGAVKLTEEDLKQLDEFYKLVGPKRDEDTSFADQMQKAA 80
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 23503235    280 LYFWDLLEGSEKAVVGTTYKHLKDLLSKLLNSGYFE 315
Cdd:pfam18293   81 EHLWALLEGKEKPVAGTTYKELKELLDKILNCGYFD 116
C1q pfam00386
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ...
949-1074 6.29e-41

C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.


Pssm-ID: 395310 [Multi-domain]  Cd Length: 126  Bit Score: 146.66  E-value: 6.29e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    949 AFSAARTSNLAPGTlDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAvNVPLYVNLMKNEEVLVSAYAND 1028
Cdd:pfam00386    1 AFSAGRTTGLTAPN-EQPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITTVD-GKSLYVSLVKNGQEVVSFYDQP 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 23503235   1029 GAPDHETASNHAILQLFQGDQIWLRLH--RGAIYGSSWKYSTFSGYLL 1074
Cdd:pfam00386   79 QKGSLDVASGSVVLELQRGDEVWLQLTgyNGLYYDGSDTDSTFSGFLL 126
C1Q smart00110
Complement component C1q domain; Globular domain found in many collagens and eponymously in ...
943-1077 1.20e-32

Complement component C1q domain; Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tumour necrosis factor.


Pssm-ID: 128420  Cd Length: 135  Bit Score: 123.18  E-value: 1.20e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235     943 PQQMRVAFSAARTSNLAPGtlDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAVNVplYVNLMKNEEVLV 1022
Cdd:smart00110    3 KAQPRSAFSVIRSNRPPPP--GQPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESKGRNV--KVSLMKNGIQVM 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 23503235    1023 SAYANDGAPDHETASNHAILQLFQGDQIWLRLHR--GAIYGSSWKYSTFSGYLLYQD 1077
Cdd:smart00110   79 STYDEYQKGLYDVASGGALLQLRQGDQVWLELPDekNGLYAGEYVDSTFSGFLLFPD 135
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
88-510 1.60e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 48.95  E-value: 1.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235     88 QVNHSQHGESQRaLSPLQSTLSSAASPSQAYEtyiENGLICLKHKIRNIEKKKLKLEDyKDRLKSGEHLNPDQLEA-VEK 166
Cdd:pfam05483  286 ELIEKKDHLTKE-LEDIKMSLQRSMSTQKALE---EDLQIATKTICQLTEEKEAQMEE-LNKAKAAHSFVVTEFEAtTCS 360
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    167 YEEVLHNLEfaKELQKTFSGLSLDLLKAQKKAQRREHMLKL----EAEKKKLRTILQVQYVL--QNLTQEHVQKDFKGG- 239
Cdd:pfam05483  361 LEELLRTEQ--QRLEKNEDQLKIITMELQKKSSELEEMTKFknnkEVELEELKKILAEDEKLldEKKQFEKIAEELKGKe 438
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    240 --LNGAVYLPSKEL-DYLIKFSKLTCPERNESLSVED---QMEQSSLYFWDLLEGSEKAVVGTT--YKHLKDLLSKLLNS 311
Cdd:pfam05483  439 qeLIFLLQAREKEIhDLEIQLTAIKTSEEHYLKEVEDlktELEKEKLKNIELTAHCDKLLLENKelTQEASDMTLELKKH 518
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    312 GyfESIpvpKNAKEKEVPLEEEMLIQSEKKTQL-SKTESVKEseslmEFAQP------EIQPQEFLNRRYMTEVDYSNKQ 384
Cdd:pfam05483  519 Q--EDI---INCKKQEERMLKQIENLEEKEMNLrDELESVRE-----EFIQKgdevkcKLDKSEENARSIEYEVLKKEKQ 588
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    385 GEEQPWEADYARK--PNLPKRWDMLTEPDGQEKKQESFKSWEASGKHQEVSKPAVSLEQRKQDTSKLRSTLPEEQKKQEI 462
Cdd:pfam05483  589 MKILENKCNNLKKqiENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKI 668
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*...
gi 23503235    463 SKSKpspsqwkqdtpkskagyVQEEQKKQETPKLWPVQLQKEQDPKKQ 510
Cdd:pfam05483  669 SEEK-----------------LLEEVEKAKAIADEAVKLQKEIDKRCQ 699
PTZ00121 PTZ00121
MAEBL; Provisional
130-569 3.21e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.13  E-value: 3.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235   130 KHKIRNIEKK---KLKLEDYKDRL---KSGEHLNPDQLEAVEKYEEVLHNLEF---AKELQKTFSGLSLDLLKAQKKAQR 200
Cdd:PTZ00121 1456 AKKAEEAKKKaeeAKKADEAKKKAeeaKKADEAKKKAEEAKKKADEAKKAAEAkkkADEAKKAEEAKKADEAKKAEEAKK 1535
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235   201 REHMLKLEaEKKKLRTILQVQYVLQnltQEHVQKdfkgglngavylpskeldylIKFSKLTCPERNESLSVEDQMEQssl 280
Cdd:PTZ00121 1536 ADEAKKAE-EKKKADELKKAEELKK---AEEKKK--------------------AEEAKKAEEDKNMALRKAEEAKK--- 1588
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235   281 yfwdlLEGSEKAVVGTTYKHLKDLLSKLLNSGYFESIPVPKNAKEKEVPLEEEMLIQSEKKtQLSKTESVKESESLMEFA 360
Cdd:PTZ00121 1589 -----AEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAE-EKKKAEELKKAEEENKIK 1662
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235   361 QPEIQPQEFLNRRYMTEVdySNKQGEEQPWEADYARKPNLPKRWDMLTEPDGQEKKQEsfkswEASGKHQEVSKPAVSLE 440
Cdd:PTZ00121 1663 AAEEAKKAEEDKKKAEEA--KKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKA-----EELKKAEEENKIKAEEA 1735
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235   441 QRK--QDTSKLRSTLPEEQKKQEISKSKPSPSQWKQDTPKSKAGYVQEEQKKQETPKlwpvqlQKEQDPKKQTPKSWTPS 518
Cdd:PTZ00121 1736 KKEaeEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKR------RMEVDKKIKDIFDNFAN 1809
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 23503235   519 MQSEQNTTKSWTTPMCEEQDSKQPETPKS----WENNVESQKHSLTSQSQISPKS 569
Cdd:PTZ00121 1810 IIEGGKEGNLVINDSKEMEDSAIKEVADSknmqLEEADAFEKHKFNKNNENGEDG 1864
 
Name Accession Description Interval E-value
Caprin-1_C pfam12287
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ...
620-885 1.03e-141

Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.


Pssm-ID: 463522 [Multi-domain]  Cd Length: 320  Bit Score: 428.06  E-value: 1.03e-141
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    620 LQDLMTQIQGTCNFMQESVLDFDKPS-SAIPTSQPPSATP-----GSPVASKEQNLSSQSDFLQEPLQATSSPVTCSSNA 693
Cdd:pfam12287    1 LQDLMAQIQGTYNFMQDSMLDFDKPSdSAIVSAQPPSQSPdlsqmVCPPASPEQRLSQQSDVLQQPEQTQVSPVSPSSNA 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    694 ClvttdqASSGSETEFMTSETPE-------------------------------------------------------VF 718
Cdd:pfam12287   81 C------ASSGSEYQFHTSEPPQpeaidpiqssmslpselappspplspasqpqvfqskpasssginvnaapfqsmqtVF 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    719 NVNAPLPPRKEQEIKE-SPYSPGYNQSFTTASTQTPPQCQLPSIHVEQTVhsqeTANYHPDGTIQVSNGSLAFYPAQTNV 797
Cdd:pfam12287  155 NVNAPVPPRNEQELKEsSQYSSGYNQSFSSQSTQTVPQCQLPSEQLEQTV----VGAYHPDGTIQVSNGHLAFYPAQTNG 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    798 FPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYK-GFDTYRG-LPSISNGNYSQLQFQAREYSGAPYSQRDNFQQCYK 875
Cdd:pfam12287  231 FPRPPQPFYNSRGSPRGGPRGGRGLMNGYRGPNGFKgGFDGYRGpFPNTPNGGYGQLQFQARDYSGTPYSQRDGYQQNYK 310
                          330
                   ....*....|
gi 23503235    876 RGGTSGGPRA 885
Cdd:pfam12287  311 RGGTQSGPRA 320
Caprin-1_dimer pfam18293
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a ...
200-315 4.49e-51

Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a role in many important biological processes, including cellular proliferation, innate immune response and synaptic plasticity. This domain is found in the highly conserved homologous region 1(HR1) and is responsible for the tight homodimerization of Caprin-1.


Pssm-ID: 436391  Cd Length: 116  Bit Score: 175.09  E-value: 4.49e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    200 RREHMLKLEAEKKKLRTILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKELDYLIKFSKLTCPERNESLSVEDQMEQSS 279
Cdd:pfam18293    1 KKEAQLKMQAELARLREVLQVQDVLNSLGSEDVRNDFLNGTNGAVKLTEEDLKQLDEFYKLVGPKRDEDTSFADQMQKAA 80
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 23503235    280 LYFWDLLEGSEKAVVGTTYKHLKDLLSKLLNSGYFE 315
Cdd:pfam18293   81 EHLWALLEGKEKPVAGTTYKELKELLDKILNCGYFD 116
C1q pfam00386
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ...
949-1074 6.29e-41

C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.


Pssm-ID: 395310 [Multi-domain]  Cd Length: 126  Bit Score: 146.66  E-value: 6.29e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    949 AFSAARTSNLAPGTlDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAvNVPLYVNLMKNEEVLVSAYAND 1028
Cdd:pfam00386    1 AFSAGRTTGLTAPN-EQPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITTVD-GKSLYVSLVKNGQEVVSFYDQP 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 23503235   1029 GAPDHETASNHAILQLFQGDQIWLRLH--RGAIYGSSWKYSTFSGYLL 1074
Cdd:pfam00386   79 QKGSLDVASGSVVLELQRGDEVWLQLTgyNGLYYDGSDTDSTFSGFLL 126
C1Q smart00110
Complement component C1q domain; Globular domain found in many collagens and eponymously in ...
943-1077 1.20e-32

Complement component C1q domain; Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tumour necrosis factor.


Pssm-ID: 128420  Cd Length: 135  Bit Score: 123.18  E-value: 1.20e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235     943 PQQMRVAFSAARTSNLAPGtlDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAVNVplYVNLMKNEEVLV 1022
Cdd:smart00110    3 KAQPRSAFSVIRSNRPPPP--GQPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESKGRNV--KVSLMKNGIQVM 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 23503235    1023 SAYANDGAPDHETASNHAILQLFQGDQIWLRLHR--GAIYGSSWKYSTFSGYLLYQD 1077
Cdd:smart00110   79 STYDEYQKGLYDVASGGALLQLRQGDQVWLELPDekNGLYAGEYVDSTFSGFLLFPD 135
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
88-510 1.60e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 48.95  E-value: 1.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235     88 QVNHSQHGESQRaLSPLQSTLSSAASPSQAYEtyiENGLICLKHKIRNIEKKKLKLEDyKDRLKSGEHLNPDQLEA-VEK 166
Cdd:pfam05483  286 ELIEKKDHLTKE-LEDIKMSLQRSMSTQKALE---EDLQIATKTICQLTEEKEAQMEE-LNKAKAAHSFVVTEFEAtTCS 360
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    167 YEEVLHNLEfaKELQKTFSGLSLDLLKAQKKAQRREHMLKL----EAEKKKLRTILQVQYVL--QNLTQEHVQKDFKGG- 239
Cdd:pfam05483  361 LEELLRTEQ--QRLEKNEDQLKIITMELQKKSSELEEMTKFknnkEVELEELKKILAEDEKLldEKKQFEKIAEELKGKe 438
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    240 --LNGAVYLPSKEL-DYLIKFSKLTCPERNESLSVED---QMEQSSLYFWDLLEGSEKAVVGTT--YKHLKDLLSKLLNS 311
Cdd:pfam05483  439 qeLIFLLQAREKEIhDLEIQLTAIKTSEEHYLKEVEDlktELEKEKLKNIELTAHCDKLLLENKelTQEASDMTLELKKH 518
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    312 GyfESIpvpKNAKEKEVPLEEEMLIQSEKKTQL-SKTESVKEseslmEFAQP------EIQPQEFLNRRYMTEVDYSNKQ 384
Cdd:pfam05483  519 Q--EDI---INCKKQEERMLKQIENLEEKEMNLrDELESVRE-----EFIQKgdevkcKLDKSEENARSIEYEVLKKEKQ 588
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235    385 GEEQPWEADYARK--PNLPKRWDMLTEPDGQEKKQESFKSWEASGKHQEVSKPAVSLEQRKQDTSKLRSTLPEEQKKQEI 462
Cdd:pfam05483  589 MKILENKCNNLKKqiENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKI 668
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*...
gi 23503235    463 SKSKpspsqwkqdtpkskagyVQEEQKKQETPKLWPVQLQKEQDPKKQ 510
Cdd:pfam05483  669 SEEK-----------------LLEEVEKAKAIADEAVKLQKEIDKRCQ 699
PTZ00121 PTZ00121
MAEBL; Provisional
130-569 3.21e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.13  E-value: 3.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235   130 KHKIRNIEKK---KLKLEDYKDRL---KSGEHLNPDQLEAVEKYEEVLHNLEF---AKELQKTFSGLSLDLLKAQKKAQR 200
Cdd:PTZ00121 1456 AKKAEEAKKKaeeAKKADEAKKKAeeaKKADEAKKKAEEAKKKADEAKKAAEAkkkADEAKKAEEAKKADEAKKAEEAKK 1535
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235   201 REHMLKLEaEKKKLRTILQVQYVLQnltQEHVQKdfkgglngavylpskeldylIKFSKLTCPERNESLSVEDQMEQssl 280
Cdd:PTZ00121 1536 ADEAKKAE-EKKKADELKKAEELKK---AEEKKK--------------------AEEAKKAEEDKNMALRKAEEAKK--- 1588
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235   281 yfwdlLEGSEKAVVGTTYKHLKDLLSKLLNSGYFESIPVPKNAKEKEVPLEEEMLIQSEKKtQLSKTESVKESESLMEFA 360
Cdd:PTZ00121 1589 -----AEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAE-EKKKAEELKKAEEENKIK 1662
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235   361 QPEIQPQEFLNRRYMTEVdySNKQGEEQPWEADYARKPNLPKRWDMLTEPDGQEKKQEsfkswEASGKHQEVSKPAVSLE 440
Cdd:PTZ00121 1663 AAEEAKKAEEDKKKAEEA--KKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKA-----EELKKAEEENKIKAEEA 1735
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503235   441 QRK--QDTSKLRSTLPEEQKKQEISKSKPSPSQWKQDTPKSKAGYVQEEQKKQETPKlwpvqlQKEQDPKKQTPKSWTPS 518
Cdd:PTZ00121 1736 KKEaeEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKR------RMEVDKKIKDIFDNFAN 1809
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 23503235   519 MQSEQNTTKSWTTPMCEEQDSKQPETPKS----WENNVESQKHSLTSQSQISPKS 569
Cdd:PTZ00121 1810 IIEGGKEGNLVINDSKEMEDSAIKEVADSknmqLEEADAFEKHKFNKNNENGEDG 1864
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH