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Conserved domains on  [gi|13027410|ref|NP_076483|]
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taste receptor type 2 member 119 [Rattus norvegicus]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor( domain architecture ID 11606641)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters; olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_TAS2R1 cd15016
mammalian taste receptor 2, subtype 1, member of the seven-transmembrane G protein-coupled ...
7-287 4.22e-136

mammalian taste receptor 2, subtype 1, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 1, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


:

Pssm-ID: 320144  Cd Length: 283  Bit Score: 387.73  E-value: 4.22e-136
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410   7 LFFFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIILQLCILFAQLCLFSLVRHTLFEDNITFVF 86
Cdd:cd15016   1 IIHLLFAVIQFLTGIFANGFIVVVNGIDLIKQRKMAPLDLLLSCLATSRICLQLFIFYLNLAVLSLIKFSVFAENFVIFM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410  87 IINELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYVIITTFIHSRETSAILKPIFISLF-PKNAT 165
Cdd:cd15016  81 FVNELGLWFATWLGVFYCAKIATIAHPLFLWLKMRISKLVPWLILGSLLYASITSVFHSKYTWPISQKLLLSFFsSNATT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410 166 QVGTGHATLLSVLVLGLTLPLFIFTVAVLLLIYSLWNYSRQMR-TMVGTREYSGHAHISAMLSILSFLILYLSHYMVAVL 244
Cdd:cd15016 161 QIKEISALQLSLLIFELSLPLLIFLVAVLLLIFSLGRHTRQMRtTAAGTRDPSRSAHISALLSILSFLILYLSHYMAAAL 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 13027410 245 ISTQVLYLGSRTFVFCLLVIGMYPSIHSIVLILGNPKLKRNAK 287
Cdd:cd15016 241 LSSQIFQFGSLFFLFCILVIGAYPSGHSIILILGNPKLKQNAK 283
 
Name Accession Description Interval E-value
7tm_TAS2R1 cd15016
mammalian taste receptor 2, subtype 1, member of the seven-transmembrane G protein-coupled ...
7-287 4.22e-136

mammalian taste receptor 2, subtype 1, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 1, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320144  Cd Length: 283  Bit Score: 387.73  E-value: 4.22e-136
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410   7 LFFFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIILQLCILFAQLCLFSLVRHTLFEDNITFVF 86
Cdd:cd15016   1 IIHLLFAVIQFLTGIFANGFIVVVNGIDLIKQRKMAPLDLLLSCLATSRICLQLFIFYLNLAVLSLIKFSVFAENFVIFM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410  87 IINELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYVIITTFIHSRETSAILKPIFISLF-PKNAT 165
Cdd:cd15016  81 FVNELGLWFATWLGVFYCAKIATIAHPLFLWLKMRISKLVPWLILGSLLYASITSVFHSKYTWPISQKLLLSFFsSNATT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410 166 QVGTGHATLLSVLVLGLTLPLFIFTVAVLLLIYSLWNYSRQMR-TMVGTREYSGHAHISAMLSILSFLILYLSHYMVAVL 244
Cdd:cd15016 161 QIKEISALQLSLLIFELSLPLLIFLVAVLLLIFSLGRHTRQMRtTAAGTRDPSRSAHISALLSILSFLILYLSHYMAAAL 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 13027410 245 ISTQVLYLGSRTFVFCLLVIGMYPSIHSIVLILGNPKLKRNAK 287
Cdd:cd15016 241 LSSQIFQFGSLFFLFCILVIGAYPSGHSIILILGNPKLKQNAK 283
TAS2R pfam05296
Taste receptor protein (TAS2R); This family consists of several forms of eukaryotic taste ...
1-294 1.64e-81

Taste receptor protein (TAS2R); This family consists of several forms of eukaryotic taste receptor proteins (TAS2Rs). TAS2Rs are G protein-coupled receptors expressed in subsets of taste receptor cells of the tongue and palate epithelia in humans and mice, and are organized in the genome in clusters. The proteins are genetically linked to loci that influence bitter perception in mice and humans.


Pssm-ID: 283059  Cd Length: 303  Bit Score: 249.88  E-value: 1.64e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410     1 MMEGHILFFFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIILQLCILFAQLCLFSLVRHTLFED 80
Cdd:pfam05296   1 MLSALEGIFLIVAVVEFLLGILGNGFIVLVNCIDWVKKRKLSSIDLILTSLAISRICLQWLILLDNFIIVFFPNTYLSGK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410    81 NITFVFI----INELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYV--IITTFIHSRETSAILKP 154
Cdd:pfam05296  81 LLRIISLfwtfLNHLSLWFATCLSVFYCLKIANFSHPIFLWLKWRISKVVPWLLLGSLLISflNTVQIPNSIKASIDPEL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410   155 IFislFPKNAT-QVGTGHATLLSVLVL---GLTLPLFIFTVAVLLLIYSLWNYSRQMR-TMVGTREYSGHAHISAMLSIL 229
Cdd:pfam05296 161 IK---YKRNTTwDLRVSKFELFSSLVLlnlGSLLPFIVFLISFLLLIFSLWRHTRQMQlNSTGFRDPSTEAHVRALKSLI 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13027410   230 SFLILYLSHYMVAVL-ISTQVLYLGSRTFVFCLLVIGMYPSIHSIVLILGNPKLKRNAKMFIVHCK 294
Cdd:pfam05296 238 SFLILYISYFLSFLIsIISFLLPKNKLAFIFGEIVTYLYPSGHSFILILGNPKLKQAFLKILLKLK 303
 
Name Accession Description Interval E-value
7tm_TAS2R1 cd15016
mammalian taste receptor 2, subtype 1, member of the seven-transmembrane G protein-coupled ...
7-287 4.22e-136

mammalian taste receptor 2, subtype 1, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 1, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320144  Cd Length: 283  Bit Score: 387.73  E-value: 4.22e-136
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410   7 LFFFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIILQLCILFAQLCLFSLVRHTLFEDNITFVF 86
Cdd:cd15016   1 IIHLLFAVIQFLTGIFANGFIVVVNGIDLIKQRKMAPLDLLLSCLATSRICLQLFIFYLNLAVLSLIKFSVFAENFVIFM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410  87 IINELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYVIITTFIHSRETSAILKPIFISLF-PKNAT 165
Cdd:cd15016  81 FVNELGLWFATWLGVFYCAKIATIAHPLFLWLKMRISKLVPWLILGSLLYASITSVFHSKYTWPISQKLLLSFFsSNATT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410 166 QVGTGHATLLSVLVLGLTLPLFIFTVAVLLLIYSLWNYSRQMR-TMVGTREYSGHAHISAMLSILSFLILYLSHYMVAVL 244
Cdd:cd15016 161 QIKEISALQLSLLIFELSLPLLIFLVAVLLLIFSLGRHTRQMRtTAAGTRDPSRSAHISALLSILSFLILYLSHYMAAAL 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 13027410 245 ISTQVLYLGSRTFVFCLLVIGMYPSIHSIVLILGNPKLKRNAK 287
Cdd:cd15016 241 LSSQIFQFGSLFFLFCILVIGAYPSGHSIILILGNPKLKQNAK 283
TAS2R pfam05296
Taste receptor protein (TAS2R); This family consists of several forms of eukaryotic taste ...
1-294 1.64e-81

Taste receptor protein (TAS2R); This family consists of several forms of eukaryotic taste receptor proteins (TAS2Rs). TAS2Rs are G protein-coupled receptors expressed in subsets of taste receptor cells of the tongue and palate epithelia in humans and mice, and are organized in the genome in clusters. The proteins are genetically linked to loci that influence bitter perception in mice and humans.


Pssm-ID: 283059  Cd Length: 303  Bit Score: 249.88  E-value: 1.64e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410     1 MMEGHILFFFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIILQLCILFAQLCLFSLVRHTLFED 80
Cdd:pfam05296   1 MLSALEGIFLIVAVVEFLLGILGNGFIVLVNCIDWVKKRKLSSIDLILTSLAISRICLQWLILLDNFIIVFFPNTYLSGK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410    81 NITFVFI----INELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYV--IITTFIHSRETSAILKP 154
Cdd:pfam05296  81 LLRIISLfwtfLNHLSLWFATCLSVFYCLKIANFSHPIFLWLKWRISKVVPWLLLGSLLISflNTVQIPNSIKASIDPEL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410   155 IFislFPKNAT-QVGTGHATLLSVLVL---GLTLPLFIFTVAVLLLIYSLWNYSRQMR-TMVGTREYSGHAHISAMLSIL 229
Cdd:pfam05296 161 IK---YKRNTTwDLRVSKFELFSSLVLlnlGSLLPFIVFLISFLLLIFSLWRHTRQMQlNSTGFRDPSTEAHVRALKSLI 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13027410   230 SFLILYLSHYMVAVL-ISTQVLYLGSRTFVFCLLVIGMYPSIHSIVLILGNPKLKRNAKMFIVHCK 294
Cdd:pfam05296 238 SFLILYISYFLSFLIsIISFLLPKNKLAFIFGEIVTYLYPSGHSFILILGNPKLKQAFLKILLKLK 303
7tm_TAS2R cd13950
mammalian taste receptors type 2, member of the seven-transmembrane G protein-coupled receptor ...
8-287 5.19e-69

mammalian taste receptors type 2, member of the seven-transmembrane G protein-coupled receptor superfamily; This group represents a family of mammalian taste receptors (TAS2Rs), which function as bitter taste receptors. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320088  Cd Length: 288  Bit Score: 217.05  E-value: 5.19e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410   8 FFFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIILQlCILFAQLCLFSLVRHTLFEDNITFVFI 87
Cdd:cd13950   1 IFLIIIVGEFLIGILGNGFIVLVNCIDWIKSRKLSSIDFILTSLAISRIGLL-WTIILNSILSVFYPDIYLSGNVLRTLD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410  88 I-----NELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYVIITTFIHSRETSAIlkPIFISLFPK 162
Cdd:cd13950  80 IlwmflNHSSLWFATCLSVFYCLKIANFSHPFFLWLKWRINRVVPWLLLGSLLISLLISLPIVWVIYSV--YQNNSKEES 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410 163 NATQ----VGTGHATLLSVLVLGLTLPLFIFTVAVLLLIYSLWNYSRQMR-TMVGTREYSGHAHISAMLSILSFLILYLS 237
Cdd:cd13950 158 NNTSkfqvKKTSYFYSFILLNLGSLIPFILSLISFFLLIFSLWRHTRQMQlNATGSRDPSTEAHIRAMKSMISFLILFII 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 13027410 238 HYMVAVLISTQVLYLGSRTFV-FCLLVIGMYPSIHSIVLILGNPKLKRNAK 287
Cdd:cd13950 238 YFLALIITILSYSFLENKLAVlFCEVLMALYPSGHSFILILGNPKLKQAFL 288
7tm_TAS2R40-like cd15908
taste receptor 2, subtypes 39 and 40, and similar receptors, member of the seven-transmembrane ...
8-284 1.40e-51

taste receptor 2, subtypes 39 and 40, and similar receptors, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtypes 39 and 40, which function as bitter taste receptors. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (taste of glutamate MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320574  Cd Length: 289  Bit Score: 172.26  E-value: 1.40e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410   8 FFFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIILQLC----ILFAQLCLFSLVRHTLFEDNIT 83
Cdd:cd15908   1 FYLVILGIESIIGILGNGFIVAINLTEWVRSKRLSTSDRILIFLSLSRLCLQSWmmleNVCSLFFPSFYNEDNVYKTFKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410  84 FVFIINELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYVIITTFIHSRETSAILKPIFISLFPKN 163
Cdd:cd15908  81 IFMFLNYSSLWFAAWLSVFYCVKIANFTHPLFLWLKWRITSLMPWLLILSVLISFSTSLPFSWDVYNVYCNSSIPLPSSN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410 164 ATQVGTGHATLLSVLVL----GLTLPLFIFTVAVLLLIYSLWNYSRQMRT-MVGTREYSGHAHISAMLSILSFLILYLSH 238
Cdd:cd15908 161 STKKKYIKETNLVNLIFlynvGIFLPLIMFILSATLLILSLKRHTLQMQNnATGSRDPSMEAHMGAIKAISSFLILYIFN 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 13027410 239 YMVAVLISTQVLYLGSRTFVFCLLVIGMYPSIHSIVLILGNPKLKR 284
Cdd:cd15908 241 FVALILTLSNIFDTNSTWNILCKIIMAAYPAGHSILLILGNPKLRR 286
7tm_TAS2R16 cd15017
mammalian taste receptor 2, subtype 16, member of the seven-transmembrane G protein-coupled ...
7-287 4.31e-40

mammalian taste receptor 2, subtype 16, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 16, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320145  Cd Length: 285  Bit Score: 142.43  E-value: 4.31e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410   7 LFFFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIILQLCILFAQLCLFSLVRHTLFEDNITFVF 86
Cdd:cd15017   1 LFFMIIFVLESLAAIVQNGFIVTVLGREWVRCRRLPPGDMILACLGISRFCLQWISILNNFLSYFDFNYVFWYFGIIWDF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410  87 IiNELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYVIITTFIHSRETSAILKPIFISLFPKNATQ 166
Cdd:cd15017  81 F-NTLTFWLTSLLAVFYCVKISSFTHPIFLWLKWRISRLVPWLLLGSLIISCLSIIPSIVGNYIQAQLITSGNSSGNSTL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410 167 VGTGHAT----LLSVLVLGLTLPLFIFTVAVLLLIYSLWNYSRQMRT-MVGTREYSGHAHISAMLSILSFLILYLSHYMV 241
Cdd:cd15017 160 IYRLQAFqqyyFIPHQMVMLSIPFLLFLVSIILLMFSLCQHLGQMRHhSPGPCDPSTQAHTTALKSLAFFLIFFTSYFLT 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 13027410 242 AVLISTQVLYLGSRTFVFCLLVIGMYPSIHSIVLILGNPKLKRNAK 287
Cdd:cd15017 240 LIISIIKIIFVKNSWFWAWEAVIYAGISIHSTSLMLSSPKLRKALK 285
7tm_TAS2R42 cd15024
mammalian taste receptor 2, subtype 42, member of the seven-transmembrane G protein-coupled ...
9-286 4.54e-37

mammalian taste receptor 2, subtype 42, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 42, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320152  Cd Length: 288  Bit Score: 134.39  E-value: 4.54e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410   9 FFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIIlQLCILFAQLCLFSLVRHTLFEDNITFVFII 88
Cdd:cd15024   2 FLILAIGEFIIGMLGNGFIGLVNCSDWVKNRKISLADCILTCLAISRIG-QLLVILFDSFILVLWPHLYGTYKLAKVVSI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410  89 -----NELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYVI-----ITTFIHSRETSAILKPIFIS 158
Cdd:cd15024  81 lwtltNHLTTWFATCLSIFYFLKIANFSHPLFLWLKWRISRVLLVLLLGSLFLLFfdfllLETFSDFWLNIYTIDEGNLT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410 159 LFPKNATqvgTGHATLLSVLVLGLTLPLFIFTVAVLLLIYSLWNYSRQMRTM-VGTREYSGHAHISAMLSILSFLILYLS 237
Cdd:cd15024 161 LSSEESK---TLYVKSLILFSLIYLIPFLLSLTSLLLLFLSLVRHTRNLQLNsLGSRDSSTEAHKRAMKMVMSFLLLFII 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 13027410 238 HYMVAVLIS-TQVLYLGSRTFVFCLLVIGMYPSIHSIVLILGNPKLKRNA 286
Cdd:cd15024 238 HFFSIQLAGwIFFFLWKKQAILFVMLTSNIFPSGHSFILILGNSKLRQTA 287
7tm_TAS2R3 cd15020
mammalian taste receptor 2, subtype 3, member of the seven-transmembrane G protein-coupled ...
7-283 1.28e-36

mammalian taste receptor 2, subtype 3, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 3, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320148  Cd Length: 290  Bit Score: 133.29  E-value: 1.28e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410   7 LFFFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIILQlCILFAQLCLFSLVRHTLFEDNITFVF 86
Cdd:cd15020   1 IVFLVLTITEFILGIWVNGFIGLVNCIHWIKSKKISLSDFIITNLALSRIILL-CIIITDSLLLVFYPHFHDSGIIMQII 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410  87 II-----NELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYVIITTFIHSRE---TSAILKPIFIS 158
Cdd:cd15020  80 DIfwtfaNHLSIWLVTCLSVFYCLKIANFSHPAFLWLKWRVSRVVVWILLGSVLFSFFSTAALIKKfkiYSALRQMRLTE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410 159 LFPKNATQVGTGHATLLSVLVLGLTLPLFIFTVAVLLLIYSLWNYSRQM-RTMVGTREYSGHAHISAMLSILSFLILYLS 237
Cdd:cd15020 160 NCTEDIRRKEIEYYVAHILGALWSVIPFIVSLISYLLLILSLRRHTQQMqHHTTGSRDPSTEAHVRATKIILSFLLLFIF 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 13027410 238 HYMVAVLISTQVLYLGSRTFVFCLLVIGM-YPSIHSIVLILGNPKLK 283
Cdd:cd15020 240 YFVAFFIGSSSFFLPDTKLAIMIGELITAaYPSVHSFILILQNNKLK 286
7tm_TAS2R41-like cd15018
mammalian taste receptor 2, subtype 41, member of the seven-transmembrane G protein-coupled ...
6-283 2.07e-35

mammalian taste receptor 2, subtype 41, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 41, which functions as a bitter taste receptor. Also included is the closely related TAS2R60. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320146  Cd Length: 290  Bit Score: 130.23  E-value: 2.07e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410   6 ILFFFLVVMVqfvtGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIILQLCILFAQLclFSLVRHTLFEDNITFV 85
Cdd:cd15018   4 VLILFLLCLV----AIVGNGFIVVALGREWLLRRTLLPCDKLLVSLGASRFCLQWVVMGKNI--YVFLHPVAFPYNPVLQ 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410  86 FI------INELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYVIITTFIHSRETSAILKPIFISL 159
Cdd:cd15018  78 FLsfhwdfLNSATLWFCTWLSVFYCVKIATFTHPVFLWLKWRFSGWVPWLLLGSVGISSLTTILFFIGNHSIYQNYLRRG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410 160 FPKNATQVGTGHAT----LLSVLVLGLTLPLFIFTVAVLLLIYSLWNYSRQM-RTMVGTREYSGHAHISAMLSILSFLIL 234
Cdd:cd15018 158 LSSNNTTYNWRRSLekfyFFSLKLITWSIPTSVFLISMVLLINSLRRHTKKMlHNLSSLQDPSTQAHIKALKALISFLIL 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 13027410 235 YLSHYMVAVLISTQVLYLGSRTFVFCLLVIGMYPSIHSIVLILGNPKLK 283
Cdd:cd15018 238 FASYFLSLVLSAAGVFPSQEVRYWVWQIVIYLCIAVHPFILLFSNPKLR 286
7tm_TAS2R43-like cd15027
mammalian taste receptor 2, subtype 43, and related proteins, member of the ...
8-284 5.71e-35

mammalian taste receptor 2, subtype 43, and related proteins, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (T2R) subtype 43, which functions as a bitter taste receptor. Also included are the closely related taste receptors TAS2R19, TAS2R20, TAS2R30, TAS2R31, TAS2R45 and TAS2R50. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320155  Cd Length: 292  Bit Score: 128.85  E-value: 5.71e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410   8 FFFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIILqLCILFAQLC--LFSLVRHTLfEDNITFV 85
Cdd:cd15027   6 ILSILVMAEFVLGNFANGFIALVNCIDWVKRQKISSVDQILTALAVSRIGL-LWVILINWYatVFNPALYSL-EVRIIIH 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410  86 F---IINELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYVIITTFIHSretsaILKPIFISLFPK 162
Cdd:cd15027  84 IawaVTNHFSTWLATSLSIFYLLKIANFSNLIFLYLKRRVKSVILVILLGSLVFLVFHLAVVN-----IDENVWVNEYEG 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410 163 NATQ----VGTGHATLLSVLVLGLTLPLFIFTVAVLLLIYSLWNYSRQMR-TMVGTREYSGHAHISAMLSILSFLILYLS 237
Cdd:cd15027 159 NVTWktklRDIIHLSNMTVFTLANFIPFTMSLISFLLLIFSLCKHLKKMQlHGKGSQDPSTKVHIKALQTVISFLLLFAI 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 13027410 238 hYMVAVLIStqVLYLGS----RTFVFCLLVIGMYPSIHSIVLILGNPKLKR 284
Cdd:cd15027 239 -YFLSLIIS--VWSSNRlqnkPVLLLCQAIGILYPSSHSFILIWGNKKLKQ 286
7tm_TAS2R40 cd15014
mammalian taste receptor 2, subtype 40, member of the seven-transmembrane G-protein coupled ...
7-284 1.60e-34

mammalian taste receptor 2, subtype 40, member of the seven-transmembrane G-protein coupled receptor superfamily; This group includes the mammalian taste receptor 2 (T2R) subtype 40, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (taste of glutamate MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320142  Cd Length: 290  Bit Score: 127.75  E-value: 1.60e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410   7 LFFFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIILQLCILFAQLclFSLVRHTLFEDNITFVF 86
Cdd:cd15014   1 IIPFVVSTIECIVGIIGNGFITVIYGTEWVRSKRLPTGERLMLMLSFSRLLLQIWMMVEIT--YSLLFPIIYNHNAMYKL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410  87 I------INELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYVIITTFIHSRETSAILKPIFISLF 160
Cdd:cd15014  79 FkvisvfLNYCNLWFAAWLNVFYCLKIVNFAHPLFLLMKQKIIVLMPRLLSLSVLVSLSLSSFFSKDIFNVYVNTSVPIP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410 161 PKNATQVG----TGHATLLSVLVLGLTLPLFIFTVAVLLLIYSLWNYSRQM-RTMVGTREYSGHAHISAMLSILSFLILY 235
Cdd:cd15014 159 SSNSTKMKyffeTNVLNLAFLYYMGIFVPLFMFIMAATLLITSLKRHTLHMeSSTTGSRDSSMEAHIGAIKSTSYSLILY 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 13027410 236 LSHYMVAVLISTQVLYLGSRTFVFCLLVIGMYPSIHSIVLILGNPKLKR 284
Cdd:cd15014 239 IINALALFISMSNIFGAYSSWNSLCKIIMTAYPAGQSVHLILRNPGLRR 287
7tm_TAS2R14-like cd15019
mammalian taste receptor 2, subtype 14, member of the seven-transmembrane G protein-coupled ...
8-284 1.68e-32

mammalian taste receptor 2, subtype 14, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 14, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320147  Cd Length: 290  Bit Score: 122.25  E-value: 1.68e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410   8 FFFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIILqLCILFAQLCLFSLVRHTLFEDNITFVFI 87
Cdd:cd15019   1 IFTIILSVEFIIGNLGNGFIALVNCMDWVKRRKISSVDQILTALAISRIGL-LWLVFISWLISVLYPALLMTEKMLRIIN 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410  88 I-----NELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYVIITTFIHSRETSailkpIFISLFPK 162
Cdd:cd15019  80 IswtvtNHFSIWLATCLSIFYFLKIANFSNSIFLYLKWRVKKVVSVTLLVSLVLLFLNIVLINTHID-----VWIDGYKR 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410 163 NATQ--VGTGHATLLSVLVLGLTLPLFI-FTV---AVLLLIYSLWNYSRQM-RTMVGTREYSGHAHISAMLSILSFLILY 235
Cdd:cd15019 155 NMSYssSSSNSAQFSKLLLFTNTMFTFIpFTVsltTFLLLIFSLWKHLKKMqHNAKGSRDASTTAHIKALQTVIAFLLLY 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 13027410 236 LSHYMVAVLISTQVLYLGSRTFVFCLLVIGM-YPSIHSIVLILGNPKLKR 284
Cdd:cd15019 235 TIFFLSLLVQVWSSELLEKNLIILFCQVIGIaFPSGHSCVLILGNSKLRQ 284
7tm_TAS2R10 cd15021
mammalian taste receptor 2, subtype 10, member of the seven-transmembrane G protein-coupled ...
8-284 3.56e-32

mammalian taste receptor 2, subtype 10, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 10, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320149  Cd Length: 285  Bit Score: 121.34  E-value: 3.56e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410   8 FFFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRI-ILQLCILFAQLCLFSLvrHTLFEDNIT--- 83
Cdd:cd15021   2 ILLFVVTSEAVLGVLGNGFIALVNCIDYARNKKLSKIGFILTGLAISRIfLIWIIILDAYVKLFSP--HMLASGNLIeyi 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410  84 --FVFIINELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLIlgsvLYVIITTFIHSRETSAILKPIFIsLFP 161
Cdd:cd15021  80 syIWVIINHLSVWFATSLSIFYFLKIANFSHYIFLWLKRRIDVVFIFLI----GCLLISWLISFPQVAKIINDIKM-KYR 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410 162 KNATQVGTGHATLLSVLVLGLTLPLFIFTVAV---LLLIYSLWNYSRQMRTMV-GTREYSGHAHISAMLSILSFLILYLS 237
Cdd:cd15021 155 NTSWQLHLEKSEFFINYVFTNLGVIFFFMVALitcFLLIISLWRHNRQMQSNVsGFRDLNTEAHVKAMKVLISFIILFIL 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 13027410 238 HYM-VAVLISTQVLYLGSRTFVFCLLVIGMYPSIHSIVLILGNPKLKR 284
Cdd:cd15021 235 YFIgISIETLCFFLPENKLLFIFGLTTACMYPCCHSFILILANSQLKQ 282
7tm_TAS2R8 cd15022
mammalian taste receptor 2, subtype 8, member of the seven-transmembrane G protein-coupled ...
9-284 6.63e-32

mammalian taste receptor 2, subtype 8, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 8, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320150  Cd Length: 292  Bit Score: 120.65  E-value: 6.63e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410   9 FFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIILqLCILFAQLCLFSLVRHTLFEDNITFVF-- 86
Cdd:cd15022   3 FIILITGEFIIGILGNGYIALVNWIDWIKKKKISSIDYILTSLAISRICL-ISVIVVNGIVIVLYPDVYENDKLQIVIst 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410  87 ---IINELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYVIITTFIHSRETSAILKPIFISLFPKN 163
Cdd:cd15022  82 fwtFANYLSMWFATCLNVFYLLKIANFSHPLFLWLKWRIDRVVHWILLGCFAISLLVSLILAIVLSDDYRFHAIAKHKRN 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410 164 ATQV----GTGHATLLSVLVLGLTLPLFIFTVAVLLLIYSLWNYSRQMRTMV-GTREYSGHAHISAMLSILSFLILYLSH 238
Cdd:cd15022 162 ITEMfhvsKIQYFEPLTLFNLFAIVPFTVSLISFFLLIRSLWRHTKQMKLSAtGGRDPSTEAHVRAIKTVTSFLFFFFLY 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 13027410 239 YMVAVLISTQVLYLGSRTFV-FCLLVIGMYPSIHSIVLILGNPKLKR 284
Cdd:cd15022 242 YLSSLLVTFSYLMTEYKLAMmFGEIVAILYPLGHSLILIIGNNKLRQ 288
7tm_TAS2R7-like cd15023
mammalian taste receptor 2, subtypes 7 and 9, member of the seven-transmembrane G ...
9-284 1.29e-31

mammalian taste receptor 2, subtypes 7 and 9, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtypes 7 and 9, which function as bitter taste receptors. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320151  Cd Length: 291  Bit Score: 119.88  E-value: 1.29e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410   9 FFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIILQLCILFAQ--LCLFSLVRHTLFEDNITFVF 86
Cdd:cd15023   3 YMILIAGELTIGIWGNGFIVLVNCIGWLKRRDIALIDIILISLAISRICLLCVISLDGfiMVLFPDTYGNGKLMSIIDVF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410  87 --IINELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYVIITTFIHSRETSAILKPIFISLFPKNA 164
Cdd:cd15023  83 wtFTNHSSIWFTSCLSIFYLLKIANISHPLFLWLKWRINKVILAILLGSLVLSLIISVPKTENLWDDFRKCVKTKHEENI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410 165 TQ----VGTGHATLLSVLVLGLTLPLFIFTVAVLLLIYSLWNYSRQMRTMV-GTREYSGHAHISAMLSILSFLILYLSHY 239
Cdd:cd15023 163 TLkfkvSKTQGASKQVFLNLGVLVPFILSLISFLLLLFSLVRHTKQMQLHAtGFRDPSTEAHMRAIKAVIIFLLLLIVYY 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 13027410 240 MvAVLISTQVLYLGSRTFV--FCLLVIGMYPSIHSIVLILGNPKLKR 284
Cdd:cd15023 243 L-AFLVATSSYLIPQGKLVvmFGEIITLIFPSSHSFILIMGNSKLRE 288
7tm_TAS2R13 cd15026
mammalian taste receptor 2, subtype 13, member of the seven-transmembrane G protein-coupled ...
8-284 1.44e-30

mammalian taste receptor 2, subtype 13, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 13, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320154  Cd Length: 287  Bit Score: 117.20  E-value: 1.44e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410   8 FFFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIIL----QLCILFAQLCLFSLVRHTLFEdNIT 83
Cdd:cd15026   2 ILTLIIIAEFIFGNLSNGFIVLINCIDWVKKRKLSSIDKILLILAISRIGLiwetLVYWFKAQYYSSFFITGTELR-IIV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410  84 FVFII-NELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYV---IITTFIHSREtsailkpiFISL 159
Cdd:cd15026  81 FSWILsNHFSLWLATILSIFYLLKIANFSWPIFLYLKWRIKKVILMMLLGSLVFLflnLIQINIHIED--------WFYQ 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410 160 FPKNAT--QVGTGHATLLSVLVLGLTL-PLFIFTVAV---LLLIYSLWNYSRQMRTMV-GTREYSGHAHISAMLSILSFL 232
Cdd:cd15026 153 YERNTTwnSMESDFAKFSELVLFNMTMfSVIPFTVALisfLLLIFSLWKHLQKMQLNSrGHRDPSTKAHRNALRIMVSFL 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 13027410 233 ILYLSHYMVAVLISTQVLYLGSRTFVFCLLVIGMYPSIHSIVLILGNPKLKR 284
Cdd:cd15026 233 LLYASYFLSLLISWIAQKHQSELAYIICIITGLFYPSSHSFILILGNSKLRQ 284
7tm_TAS2R38 cd15025
mammalian taste receptor 2, subtype 38, member of the seven-transmembrane G protein-coupled ...
6-284 5.22e-28

mammalian taste receptor 2, subtype 38, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (T2R) subtype 38, which functions as a bitter taste receptor. Genetic variants of human TAS2R38 influence the ability to taste synthetic compounds 6-n-propylthiouracil (PROP) and phenylthiocarbamide (PTC). Thus, sensitivity to the bitter taste of PROP is often used as a marker for individual differences in taste perception that can affect food preferences and intake. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320153  Cd Length: 293  Bit Score: 110.31  E-value: 5.22e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410   6 ILFFFLVVMvQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIILQLCILFA--QLCLFSLVRHTL---FED 80
Cdd:cd15025   1 ITFLFLSVL-EFAVGILANAFIVLVNFWDVVKRQPLNNCDIVLLCLSITRLFLQGLLFLDaiQLTHFQQMKDPLshsYQA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410  81 NITFVFIINELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYVIITTFIHSRETSAILKPIFISLF 160
Cdd:cd15025  80 IIMLWMIANQVSLWLAACLSLLYCSKIARFSHTFLLCLASWVSRRIPQMLLGSLLFSCICTVLCVWDFFSRSHSTVTSSL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410 161 PKNATQVGTGHATLLSVLV-----LGLTLPLFIFTVAVLLLIYSLWNYSRQMRTMV-GTREYSGHAHISAMLSILSFLIL 234
Cdd:cd15025 160 HMNNTELNLQIEKLNFFYSflfcnVGSVPPFLLFLVSSGVLIISLGRHMRTMKAQTsGSRDPSLEAHIRALKSLVSFLCF 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 13027410 235 YLSHYMVAVLISTQVLYLGSRTFVF-CLLVIGMYPSIHSIVLILGNPKLKR 284
Cdd:cd15025 240 YVVSFCAALISVPLLLLWHNKIGVMvCVGIMAACPSGHAAILISGNAKLRR 290
7tm_TAS2R39 cd15015
mammalian taste receptor 2, subtype 39, member of the seven-transmembrane G protein-coupled ...
12-287 7.25e-28

mammalian taste receptor 2, subtype 39, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (T2R) subtype 39, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (taste of glutamate MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320143  Cd Length: 289  Bit Score: 110.00  E-value: 7.25e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410  12 VVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIILQLCILF---AQLCLFSLVRHTLFE-DNITFVFI 87
Cdd:cd15015   6 LVATECTIGIIASGIIMAVNAVSWVQKKAVSITTRILLLLSVSRIGLQSIMLIeitSSIFNLSFYNSVLYRvSKVSFVFL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410  88 iNELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYVIITTFIHSRETSAILKPIFISLFPKNATQ- 166
Cdd:cd15015  86 -NYCSLWFAALLSFFHFVKIANFSYPLFFKLKWRISELMPWLLWLSVFISFSSSMFFINHKTTVCNNSSLSSNICNFTMk 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410 167 ---VGTGHATLLSVLVLGLTLPLFIFTVAVLLLIYSLWNYSRQMRT-MVGTREYSGHAHISAMLSILSFLILYLSHYMVA 242
Cdd:cd15015 165 lyvSEINVVNVAFLFNLGILPPLTMFIATATLLIFSLRRHTLHMRNnATGSRNPSMEAHMQAIKETSCFLFLYILNAAAL 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 13027410 243 VLISTQVLYLGSRTFVFCLLVIGMYPSIHSIVLILGNPKLKRNAK 287
Cdd:cd15015 245 FLSTSNIFDASLFWSNVCRIILPVYPAGHSVLLIQDNPGLRRTWK 289
7tm_TAS2R4 cd15013
mammalian taste receptor 2, subtype 4, member of the seven-transmembrane G protein-coupled ...
8-287 1.26e-24

mammalian taste receptor 2, subtype 4, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 4, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320141  Cd Length: 286  Bit Score: 101.04  E-value: 1.26e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410   8 FFFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIIL--QLCILFAQLCLFSLVRHTLFEDNITFV 85
Cdd:cd15013   2 FVFIASVVFNFVGIVANLFIIVVNCKTWVKSHRISSSDRILFSLAITRFLMlgLFLLNTIYIATFPGSRSVYFSTFFLLC 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410  86 FI-INELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYVIITTFIHSRETSAILKPIFISLFPKNA 164
Cdd:cd15013  82 WKfLDSNSLWFVTLLNILYCVKITNFQHSVFLLLKRNLSPKTPWLLLACLLISAFTTLLYIVLSQISPFPEHIIGRNNTS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027410 165 TQVGTGHATLLSVLVLGLTLPLFIFTVAVLLLIYSLWNYSRQM-RTMVGTREYSGHAHISAMLSILSFLILYLShYMVAV 243
Cdd:cd15013 162 FDISDGILTLVASLILSSSLQFILNVTSASLLIHSLRRHIQKMqKNATSFWNPQTEAHVGAMKLMIYFLILYIP-YSIAT 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 13027410 244 LISTQVLYLGS--RTFVFCLLVIGMYPSIHSIVLILGNPKLKRNAK 287
Cdd:cd15013 241 LLYFLPSYMGKnlRAQSICMIFTTLYSPGHSVLIIITHPKLKAKAK 286
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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