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Conserved domains on  [gi|13129092|ref|NP_076997|]
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voltage-gated monoatomic cation channel TMEM109 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BRI3BP super family cl20846
Negative regulator of p53/TP53; This family of transmembrane proteins is found in eukaryotes. ...
 57-231 2.94e-42

Negative regulator of p53/TP53; This family of transmembrane proteins is found in eukaryotes. Proteins in this family are typically between 213 and 245 amino acids in length. It is found in various tissues, including the brain, liver and kidneys. It was first discovered as a functional unknown gene, murine brain I3 (BRI3). This protein is also known as HCCRBP-1 and it plays a role in tumourigenesis, as it binds to an oncogene, HCCR-1, and acts as a negative regulator of p53/TP53 tumour suppressor. BRI3BP induces tumourigenesis by activating protein kinase C (PKC) activity but decreasing the pro-apoptotic PKC-alpha and PKC-delta isoform levels. BRI3BP is over-expressed in many tumours.


The actual alignment was detected with superfamily member pfam14965:

Pssm-ID: 464410  Cd Length: 180  Bit Score: 141.69  E-value: 2.94e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129092    57 IGRSVRGTLDAWIGPETMHLVSESSSQVLWAISSAISVAFFALSGIAAQLLNALGLAGDYLAQGLKLSPGQVQTFLLWGA 136
Cdd:pfam14965   1 LGRGVYQTLESVFGEENVRALLEFLSTLTERFSSGVSSALNTLARIWTDLLDALGIDGSNLFSPLALTPEPVQTVLLWGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129092   137 GALVVYWLLSLLLGLVLALLGRILWGLKLVIFLAGFVALMRSVPDPSTRALLLLALLILY-----ALLSRLTGSRASGAQ 211
Cdd:pfam14965  81 LALLGYWFLSLLLGLLFALLGRVFWLLKVVLFLASFLYILSKYEGPPETAALPLLGLVAVyvllgPLGSYWRSSPSSGAH 160

                         170       180
                  ....*....|....*....|
gi 13129092   212 LEAKVRGLERQVEELRWRQR 231
Cdd:pfam14965 161 LEAKVRHLERQVRELNRRQS 180
 
Name Accession Description Interval E-value
BRI3BP pfam14965
Negative regulator of p53/TP53; This family of transmembrane proteins is found in eukaryotes. ...
 57-231 2.94e-42

Negative regulator of p53/TP53; This family of transmembrane proteins is found in eukaryotes. Proteins in this family are typically between 213 and 245 amino acids in length. It is found in various tissues, including the brain, liver and kidneys. It was first discovered as a functional unknown gene, murine brain I3 (BRI3). This protein is also known as HCCRBP-1 and it plays a role in tumourigenesis, as it binds to an oncogene, HCCR-1, and acts as a negative regulator of p53/TP53 tumour suppressor. BRI3BP induces tumourigenesis by activating protein kinase C (PKC) activity but decreasing the pro-apoptotic PKC-alpha and PKC-delta isoform levels. BRI3BP is over-expressed in many tumours.


Pssm-ID: 464410  Cd Length: 180  Bit Score: 141.69  E-value: 2.94e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129092    57 IGRSVRGTLDAWIGPETMHLVSESSSQVLWAISSAISVAFFALSGIAAQLLNALGLAGDYLAQGLKLSPGQVQTFLLWGA 136
Cdd:pfam14965   1 LGRGVYQTLESVFGEENVRALLEFLSTLTERFSSGVSSALNTLARIWTDLLDALGIDGSNLFSPLALTPEPVQTVLLWGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129092   137 GALVVYWLLSLLLGLVLALLGRILWGLKLVIFLAGFVALMRSVPDPSTRALLLLALLILY-----ALLSRLTGSRASGAQ 211
Cdd:pfam14965  81 LALLGYWFLSLLLGLLFALLGRVFWLLKVVLFLASFLYILSKYEGPPETAALPLLGLVAVyvllgPLGSYWRSSPSSGAH 160

                         170       180
                  ....*....|....*....|
gi 13129092   212 LEAKVRGLERQVEELRWRQR 231
Cdd:pfam14965 161 LEAKVRHLERQVRELNRRQS 180
 
Name Accession Description Interval E-value
BRI3BP pfam14965
Negative regulator of p53/TP53; This family of transmembrane proteins is found in eukaryotes. ...
 57-231 2.94e-42

Negative regulator of p53/TP53; This family of transmembrane proteins is found in eukaryotes. Proteins in this family are typically between 213 and 245 amino acids in length. It is found in various tissues, including the brain, liver and kidneys. It was first discovered as a functional unknown gene, murine brain I3 (BRI3). This protein is also known as HCCRBP-1 and it plays a role in tumourigenesis, as it binds to an oncogene, HCCR-1, and acts as a negative regulator of p53/TP53 tumour suppressor. BRI3BP induces tumourigenesis by activating protein kinase C (PKC) activity but decreasing the pro-apoptotic PKC-alpha and PKC-delta isoform levels. BRI3BP is over-expressed in many tumours.


Pssm-ID: 464410  Cd Length: 180  Bit Score: 141.69  E-value: 2.94e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129092    57 IGRSVRGTLDAWIGPETMHLVSESSSQVLWAISSAISVAFFALSGIAAQLLNALGLAGDYLAQGLKLSPGQVQTFLLWGA 136
Cdd:pfam14965   1 LGRGVYQTLESVFGEENVRALLEFLSTLTERFSSGVSSALNTLARIWTDLLDALGIDGSNLFSPLALTPEPVQTVLLWGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129092   137 GALVVYWLLSLLLGLVLALLGRILWGLKLVIFLAGFVALMRSVPDPSTRALLLLALLILY-----ALLSRLTGSRASGAQ 211
Cdd:pfam14965  81 LALLGYWFLSLLLGLLFALLGRVFWLLKVVLFLASFLYILSKYEGPPETAALPLLGLVAVyvllgPLGSYWRSSPSSGAH 160

                         170       180
                  ....*....|....*....|
gi 13129092   212 LEAKVRGLERQVEELRWRQR 231
Cdd:pfam14965 161 LEAKVRHLERQVRELNRRQS 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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