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Conserved domains on  [gi|13129116|ref|NP_077011|]
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zinc finger protein 426 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
42-98 1.18e-29

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 110.76  E-value: 1.18e-29
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 13129116     42 VTFDDVAVDFTQEEWTLLDSTQRSLYSDVMLENYKNLATVGGQIIKPSLISWLEQEE 98
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGE 57
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
334-486 1.88e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.88e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 334 KPYVCKECGKAFTQYSGLSMHVRS--HSG--DKPYECKE--CGKSFLTSSRLIQHIRTHTGEKPFVCV--ECGKAFAVSS 405
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 406 NLSGHLRTH-------TEEKACECKICGKVFGYPSCLNNHMRTHSAQKPYTCK--ECGKAFNYSTHLKIHMRIHTGEKPY 476
Cdd:COG5048 368 NNEPPQSLQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170
                ....*....|
gi 13129116 477 ECKQCGKAFS 486
Cdd:COG5048 448 LCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-319 2.36e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.36e-05
                          10        20
                  ....*....|....*....|....*.
gi 13129116   294 YLSIHMRTHTGEKPYECKECGKAFNY 319
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
490-515 1.61e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.61e-04
                          10        20
                  ....*....|....*....|....*.
gi 13129116   490 SFQIHERTHTGEKPYECKECGKAFTC 515
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 224-246 6.79e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 6.79e-04
                          10        20
                  ....*....|....*....|...
gi 13129116   224 FECSHCGKSFINESYLQAHMRTH 246
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
518-543 3.65e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.65e-03
                          10        20
                  ....*....|....*....|....*.
gi 13129116   518 SFRIHEKTHTEEKPYKCQQCGKAYSH 543
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
42-98 1.18e-29

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 110.76  E-value: 1.18e-29
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 13129116     42 VTFDDVAVDFTQEEWTLLDSTQRSLYSDVMLENYKNLATVGGQIIKPSLISWLEQEE 98
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGE 57
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 41-82 2.60e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.53  E-value: 2.60e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 13129116    41 SVTFDDVAVDFTQEEWTLLDSTQRSLYSDVMLENYKNLATVG 82
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 42-79 8.56e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 8.56e-18
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 13129116  42 VTFDDVAVDFTQEEWTLLDSTQRSLYSDVMLENYKNLA 79
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
334-486 1.88e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.88e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 334 KPYVCKECGKAFTQYSGLSMHVRS--HSG--DKPYECKE--CGKSFLTSSRLIQHIRTHTGEKPFVCV--ECGKAFAVSS 405
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 406 NLSGHLRTH-------TEEKACECKICGKVFGYPSCLNNHMRTHSAQKPYTCK--ECGKAFNYSTHLKIHMRIHTGEKPY 476
Cdd:COG5048 368 NNEPPQSLQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170
                ....*....|
gi 13129116 477 ECKQCGKAFS 486
Cdd:COG5048 448 LCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
462-487 6.92e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 6.92e-06
                          10        20
                  ....*....|....*....|....*.
gi 13129116   462 HLKIHMRIHTGEKPYECKQCGKAFSH 487
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-319 2.36e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.36e-05
                          10        20
                  ....*....|....*....|....*.
gi 13129116   294 YLSIHMRTHTGEKPYECKECGKAFNY 319
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
490-515 1.61e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.61e-04
                          10        20
                  ....*....|....*....|....*.
gi 13129116   490 SFQIHERTHTGEKPYECKECGKAFTC 515
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 224-246 6.79e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 6.79e-04
                          10        20
                  ....*....|....*....|...
gi 13129116   224 FECSHCGKSFINESYLQAHMRTH 246
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 278-361 2.15e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 278 KPYKCK--ECGKGYRYPAYLSIHMRT-HTGEKPYECKECGKafnySNSFQIHgrthtgEKPYVCKECGKAFTQYSGLSMH 354
Cdd:COG5189 348 KPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----MNIFSAK------DKPYRCEVCDKRYKNLNGLKYH 417


                ....*..
gi 13129116 355 vRSHSGD 361
Cdd:COG5189 418 -RKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
518-543 3.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.65e-03
                          10        20
                  ....*....|....*....|....*.
gi 13129116   518 SFRIHEKTHTEEKPYKCQQCGKAYSH 543
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
42-98 1.18e-29

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 110.76  E-value: 1.18e-29
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 13129116     42 VTFDDVAVDFTQEEWTLLDSTQRSLYSDVMLENYKNLATVGGQIIKPSLISWLEQEE 98
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGE 57
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 41-82 2.60e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.53  E-value: 2.60e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 13129116    41 SVTFDDVAVDFTQEEWTLLDSTQRSLYSDVMLENYKNLATVG 82
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 42-79 8.56e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 8.56e-18
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 13129116  42 VTFDDVAVDFTQEEWTLLDSTQRSLYSDVMLENYKNLA 79
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
334-486 1.88e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.88e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 334 KPYVCKECGKAFTQYSGLSMHVRS--HSG--DKPYECKE--CGKSFLTSSRLIQHIRTHTGEKPFVCV--ECGKAFAVSS 405
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 406 NLSGHLRTH-------TEEKACECKICGKVFGYPSCLNNHMRTHSAQKPYTCK--ECGKAFNYSTHLKIHMRIHTGEKPY 476
Cdd:COG5048 368 NNEPPQSLQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170
                ....*....|
gi 13129116 477 ECKQCGKAFS 486
Cdd:COG5048 448 LCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
148-539 3.45e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 3.45e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 148 CEQCGEVFSEHSCLKTHVRTQSTGNTHDCNQYGKDflTLCEKTSTGEKLSEFNQSEKIFSLTPNIVYQR--TSTQEKSFE 225
Cdd:COG5048  36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCD--KSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNskASSSSLSSS 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 226 CSHCGKSFINESYLQAHMR----THNGEKLYEWRNYG-PGFIdsTSLSVLIETLNAKKPYKCKECGKGYRYPAYLSIHMR 300
Cdd:COG5048 114 SSNSNDNNLLSSHSLPPSSrdpqLPDLLSISNLRNNPlPGNN--SSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 301 THTGEKPYECKECGKAFN-YSNSFQIHGRTHTgEKPYVCKECGKAFTQYSGLSMHVRSHSGDKPYECKECGKSFLTSSRL 379
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYsIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 380 IQHIRTHTGE-------KPFVCVECGKAFAVSSNLSGHLRT--HTEEKA----CECKICGKVFGYPSCLNNHMRTHSAQK 446
Cdd:COG5048 271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLkpfsCPYSLCGKLFSRNDALKRHILLHTSIS 350

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 447 PYTCKEC------GKAFNYSTHLKIHMR-IHTGEKPYEC--KQCGKAFSHSSSFQIHERTHTGEKPYECK--ECGKAFTC 515
Cdd:COG5048 351 PAKEKLLnssskfSPLLNNEPPQSLQQYkDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                       410       420
                ....*....|....*....|....
gi 13129116 516 SSSFRIHEKTHTEEKPYKCQQCGK 539
Cdd:COG5048 431 HYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
263-554 3.79e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 3.79e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 263 DSTSLSVLIETLNAKKPYKCKECGKGYRYPAYLSIHMRTHTGEKPYECKECGKAFNYSN--SFQIHGRTHTGEKPYVCKE 340
Cdd:COG5048  17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSK 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 341 CGKAFTQYSGLSMHVRSHSGDkPYECKECGKSFLTSSRLIQHI----RTHTGEKPF---------------------VCV 395
Cdd:COG5048  97 SLPLSNSKASSSSLSSSSSNS-NDNNLLSSHSLPPSSRDPQLPdllsISNLRNNPLpgnnsssvntpqsnslhpplpANS 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 396 ECGKAFAVSSNLSGHLRTHTEEKACECKICGKVFGYPSCLNNHMRTHS-----AQKPYTCKECGKAFNYSTHLKIHMRIH 470
Cdd:COG5048 176 LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSssslpLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 471 TGEKPYECKQCGKAFSHSSSFQIHERTHTG-EKPYECKECGKAFTCSSSFRIHEKT--HTEE--KPYKC--QQCGKAYSH 543
Cdd:COG5048 256 SASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSR 335

                       330
                ....*....|.
gi 13129116 544 PRSLRRHEQIH 554
Cdd:COG5048 336 NDALKRHILLH 346
zf-H2C2_2 pfam13465
Zinc-finger double domain;
462-487 6.92e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 6.92e-06
                          10        20
                  ....*....|....*....|....*.
gi 13129116   462 HLKIHMRIHTGEKPYECKQCGKAFSH 487
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-319 2.36e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.36e-05
                          10        20
                  ....*....|....*....|....*.
gi 13129116   294 YLSIHMRTHTGEKPYECKECGKAFNY 319
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
490-515 1.61e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.61e-04
                          10        20
                  ....*....|....*....|....*.
gi 13129116   490 SFQIHERTHTGEKPYECKECGKAFTC 515
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
435-459 3.93e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.93e-04
                          10        20
                  ....*....|....*....|....*
gi 13129116   435 LNNHMRTHSAQKPYTCKECGKAFNY 459
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
218-521 6.64e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 6.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 218 STQEKSFECSHCGKSFINESYLQAHMRTHNGEKLYEWRNYG--PGFIDSTSLSVLIETLNAKKPYKC-KECGKGYRYPAY 294
Cdd:COG5048  28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGcdKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASS 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 295 LSIHMRTHTGEKPYECKECGKAFNYSNSFQIHGRTHT---GEKPYVCKECGKAFTQYSGLSMHVRSHSGDKPyecKECGK 371
Cdd:COG5048 108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKD---PSSNL 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 372 SFLTSSRLIQHIRTHT----------------------GEKPFVCVECGKAFAVSSNLSGHLRTHTEEKACECKICG--- 426
Cdd:COG5048 185 SLLISSNVSTSIPSSSensplsssysipssssdqnlenSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrss 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 427 ---KVFGYPSCLNNHMRTHSAQ-KPYTCKECGKAFNYSTHLKIHMR--IHTGE--KPYEC--KQCGKAFSHSSSFQIHER 496
Cdd:COG5048 265 lptASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                       330       340
                ....*....|....*....|....*
gi 13129116 497 THTGEKPYECKECgkafTCSSSFRI 521
Cdd:COG5048 345 LHTSISPAKEKLL----NSSSKFSP 365
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 224-246 6.79e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 6.79e-04
                          10        20
                  ....*....|....*....|...
gi 13129116   224 FECSHCGKSFINESYLQAHMRTH 246
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
351-375 7.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.15e-04
                          10        20
                  ....*....|....*....|....*
gi 13129116   351 LSMHVRSHSGDKPYECKECGKSFLT 375
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 448-470 1.98e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.98e-03
                          10        20
                  ....*....|....*....|...
gi 13129116   448 YTCKECGKAFNYSTHLKIHMRIH 470
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 278-361 2.15e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129116 278 KPYKCK--ECGKGYRYPAYLSIHMRT-HTGEKPYECKECGKafnySNSFQIHgrthtgEKPYVCKECGKAFTQYSGLSMH 354
Cdd:COG5189 348 KPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----MNIFSAK------DKPYRCEVCDKRYKNLNGLKYH 417


                ....*..
gi 13129116 355 vRSHSGD 361
Cdd:COG5189 418 -RKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
518-543 3.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.65e-03
                          10        20
                  ....*....|....*....|....*.
gi 13129116   518 SFRIHEKTHTEEKPYKCQQCGKAYSH 543
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
378-402 3.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.80e-03
                          10        20
                  ....*....|....*....|....*
gi 13129116   378 RLIQHIRTHTGEKPFVCVECGKAFA 402
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
322-347 5.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 13129116   322 SFQIHGRTHTGEKPYVCKECGKAFTQ 347
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 476-498 8.21e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.21e-03
                          10        20
                  ....*....|....*....|...
gi 13129116   476 YECKQCGKAFSHSSSFQIHERTH 498
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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