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Conserved domains on  [gi|110815800|ref|NP_077321|]
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DDB1- and CUL4-associated factor 10 isoform a [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11457048)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
168-334 1.62e-22

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 1.62e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 168 HGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKV 246
Cdd:COG2319  162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLAT-GKLL 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 247 CTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRYTedgCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILH 326
Cdd:COG2319  240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLW 315


                 ....*...
gi 110815800 327 DLDLTKSL 334
Cdd:COG2319  316 DLATGKLL 323
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 517-555 5.67e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 5.67e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 110815800   517 PLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLY 555
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
168-334 1.62e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 1.62e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 168 HGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKV 246
Cdd:COG2319  162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLAT-GKLL 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 247 CTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRYTedgCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILH 326
Cdd:COG2319  240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLW 315


                 ....*...
gi 110815800 327 DLDLTKSL 334
Cdd:COG2319  316 DLATGKLL 323
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 164-319 3.28e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 3.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 164 STRTH-GAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRK 241
Cdd:cd00200  130 TLRGHtDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLST 208

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 110815800 242 LnTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDtnryTEDGCPHKKFF-HTRFLMRMRLTPDcSKMLISTSS 319
Cdd:cd00200  209 G-KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSgHTNSVTSLAWSPD-GKRLASGSA 281
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 244-281 3.81e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.81e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 110815800   244 TKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 281
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
243-281 1.38e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.38e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 110815800  243 NTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 281
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 224-281 1.25e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 1.25e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 110815800 224 LFATCSDDTTIALWDLRKLNTKV-------CTLHGHTSWVKNIEYD-TNTRLLVTSGFDGNVIIWD 281
Cdd:PTZ00420  89 ILASGSEDLTIRVWEIPHNDESVkeikdpqCILKGHKKKISIIDWNpMNYYIMCSSGFDSFVNIWD 154
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 517-555 5.67e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 5.67e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 110815800   517 PLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLY 555
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
168-334 1.62e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 1.62e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 168 HGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKV 246
Cdd:COG2319  162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLAT-GKLL 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 247 CTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRYTedgCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILH 326
Cdd:COG2319  240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLW 315


                 ....*...
gi 110815800 327 DLDLTKSL 334
Cdd:COG2319  316 DLATGKLL 323
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 164-319 3.28e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 3.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 164 STRTH-GAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRK 241
Cdd:cd00200  130 TLRGHtDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLST 208

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 110815800 242 LnTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDtnryTEDGCPHKKFF-HTRFLMRMRLTPDcSKMLISTSS 319
Cdd:cd00200  209 G-KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSgHTNSVTSLAWSPD-GKRLASGSA 281
WD40 COG2319
WD40 repeat [General function prediction only];
168-558 4.08e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.67  E-value: 4.08e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 168 HGAVFNLEYSPDGSVLTVACEQTEVLLFDpISSKHIKTLSEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKV 246
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVRLWD-LATGLLLRTLTGHTGAVRSVAFSpDGKTLASGSADGTVRLWDLAT-GKLL 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 247 CTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTnryTEDGCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILH 326
Cdd:COG2319  156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL---ATGKLLRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVRLW 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 327 DLDLTKSLEVGSypilrarrttsssdlttsssssgprvsgspcHHSDSNSS------EKHMsrASqregVSPRNSL---E 397
Cdd:COG2319  232 DLATGKLLRTLT-------------------------------GHSGSVRSvafspdGRLL--AS----GSADGTVrlwD 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 398 VVTPEVLGE-SDHGNCITSLQLHPKGwATLLrcSSNSDDEecTCVYEFQEGAPVRPVSPRcslrlthyieeanvgRGYIK 476
Cdd:COG2319  275 LATGELLRTlTGHSGGVNSVAFSPDG-KLLA--SGSDDGT--VRLWDLATGKLLRTLTGH---------------TGAVR 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 477 ELCFSPDGRMI-SSPHGYGIRLLgfdkqcselvdclpkEASPLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLY 555
Cdd:COG2319  335 SVAFSPDGKTLaSGSDDGTVRLW---------------DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399


                 ...
gi 110815800 556 QPK 558
Cdd:COG2319  400 DLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 169-319 1.33e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.32  E-value: 1.33e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 169 GAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVC 247
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASaDGTYLASGSSDKTIRLWDLET-GECVR 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 110815800 248 TLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRYTEDGCPHkkfFHTRFLMRMRLTPDcsKMLISTSS 319
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR---GHTDWVNSVAFSPD--GTFVASSS 154
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 169-336 5.18e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.61  E-value: 5.18e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 169 GAVFNLEYSPDG-SVLTVACEQTeVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKV 246
Cdd:cd00200   52 GPVRDVAASADGtYLASGSSDKT-IRLWDLETGECVRTL-TGHTSYVSSVAFSpDGRILSSSSRDKTIKVWDVET-GKCL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 247 CTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNrytedGCPHKKFF--HTRFLMRMRLTPDcSKMLISTSSGYLLI 324
Cdd:cd00200  129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR-----TGKCVATLtgHTGEVNSVAFSPD-GEKLLSSSSDGTIK 202

                        170
                 ....*....|..
gi 110815800 325 LHDLDLTKSLEV 336
Cdd:cd00200  203 LWDLSTGKCLGT 214
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 169-281 4.78e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.92  E-value: 4.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 169 GAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVC 247
Cdd:cd00200  178 GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL-RGHENGVNSVAFSpDGYLLASGSEDGTIRVWDLRT-GECVQ 255

                         90       100       110
                 ....*....|....*....|....*....|....
gi 110815800 248 TLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 281
Cdd:cd00200  256 TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
163-558 4.76e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.10  E-value: 4.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 163 LSTRTHGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLSeAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRK 241
Cdd:COG2319   31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL-GHTAAVLSVAFSpDGRLLASASADGTVRLWDLAT 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 242 lNTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDtnryTEDG-CPHKKFFHTRFLMRMRLTPDcSKMLISTSSG 320
Cdd:COG2319  110 -GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD----LATGkLLRTLTGHSGAVTSVAFSPD-GKLLASGSDD 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 321 YLLILHDLD---LTKSLEVGSYPILRARrttsssdlttsssssgprvsgspchhsdsnssekhmsrasqregVSPRNSL- 396
Cdd:COG2319  184 GTVRLWDLAtgkLLRTLTGHTGAVRSVA--------------------------------------------FSPDGKLl 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 397 ------------EVVTPEVLGE-SDHGNCITSLQLHPKGwATLLrcsSNSDDEEcTCVYEFQEGAPVRpvsprcslRLTH 463
Cdd:COG2319  220 asgsadgtvrlwDLATGKLLRTlTGHSGSVRSVAFSPDG-RLLA---SGSADGT-VRLWDLATGELLR--------TLTG 286

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 464 yieeanvGRGYIKELCFSPDGRMI-SSPHGYGIRLLgfdkqcselvdclpkEASPLRVIRSLYSHNDVVLTTKFSPTHCQ 542
Cdd:COG2319  287 -------HSGGVNSVAFSPDGKLLaSGSDDGTVRLW---------------DLATGKLLRTLTGHTGAVRSVAFSPDGKT 344

                        410
                 ....*....|....*.
gi 110815800 543 IASGCLSGRVSLYQPK 558
Cdd:COG2319  345 LASGSDDGTVRLWDLA 360
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 244-281 3.81e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.81e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 110815800   244 TKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 281
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
243-281 1.38e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.38e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 110815800  243 NTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 281
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 224-281 1.25e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 1.25e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 110815800 224 LFATCSDDTTIALWDLRKLNTKV-------CTLHGHTSWVKNIEYD-TNTRLLVTSGFDGNVIIWD 281
Cdd:PTZ00420  89 ILASGSEDLTIRVWEIPHNDESVkeikdpqCILKGHKKKISIIDWNpMNYYIMCSSGFDSFVNIWD 154
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 246-334 2.03e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 2.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815800 246 VCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTnryteDGCPHKKFF--HTRFLMRMRLTPDcSKMLISTSSGYLL 323
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-----ETGELLRTLkgHTGPVRDVAASAD-GTYLASGSSDKTI 75

                         90
                 ....*....|.
gi 110815800 324 ILHDLDLTKSL 334
Cdd:cd00200   76 RLWDLETGECV 86
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 199-238 3.29e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.29e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 110815800   199 SSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWD 238
Cdd:smart00320   1 SGELLKTL-KGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
200-238 1.76e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.76e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 110815800  200 SKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWD 238
Cdd:pfam00400   1 GKLLKTL-EGHTGSVTSLAFSpDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 517-555 5.67e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 5.67e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 110815800   517 PLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLY 555
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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