Bardet-Biedl syndrome 1 protein [Homo sapiens]
Protein Classification
Bardet-Biedl syndrome 1 protein( domain architecture ID 10632206)
Bardet-Biedl syndrome 1 protein is a component of the BBSome complex, which is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| BBS1 | pfam14779 | Ciliary BBSome complex subunit 1; The BBSome (so-named after the association with Bardet-Biedl ... |
23-276 | 4.41e-129 | |||||
Ciliary BBSome complex subunit 1; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS1 predominantly localizes to the basal body and or transitional zone of ciliated cells. It has been found in a heptameric complex with BBS2, BBS5, BBS7, BBS8, and BBS9, termed the BBSome. Mutations in BBS1 can lead to retinal inadequacy. : Pssm-ID: 464312 Cd Length: 254 Bit Score: 378.48 E-value: 4.41e-129
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| Name | Accession | Description | Interval | E-value | |||||
| BBS1 | pfam14779 | Ciliary BBSome complex subunit 1; The BBSome (so-named after the association with Bardet-Biedl ... |
23-276 | 4.41e-129 | |||||
Ciliary BBSome complex subunit 1; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS1 predominantly localizes to the basal body and or transitional zone of ciliated cells. It has been found in a heptameric complex with BBS2, BBS5, BBS7, BBS8, and BBS9, termed the BBSome. Mutations in BBS1 can lead to retinal inadequacy. Pssm-ID: 464312 Cd Length: 254 Bit Score: 378.48 E-value: 4.41e-129
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| Name | Accession | Description | Interval | E-value | |||||
| BBS1 | pfam14779 | Ciliary BBSome complex subunit 1; The BBSome (so-named after the association with Bardet-Biedl ... |
23-276 | 4.41e-129 | |||||
Ciliary BBSome complex subunit 1; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS1 predominantly localizes to the basal body and or transitional zone of ciliated cells. It has been found in a heptameric complex with BBS2, BBS5, BBS7, BBS8, and BBS9, termed the BBSome. Mutations in BBS1 can lead to retinal inadequacy. Pssm-ID: 464312 Cd Length: 254 Bit Score: 378.48 E-value: 4.41e-129
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