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Conserved domains on  [gi|90186267|ref|NP_078945|]
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ankyrin repeat domain-containing protein 55 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11430360)

ankyrin repeat (ANK) domain-containing protein mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

CATH:  1.25.40.20
Gene Ontology:  GO:0005515
PubMed:  33435370|15152081|17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
27-267 3.00e-40

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 148.56  E-value: 3.00e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  27 DLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGW 106
Cdd:COG0666  53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267 107 LEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSniSEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGA 186
Cdd:COG0666 133 LEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAG--ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267 187 DPTLVDKDFKTALHWAVQSGNRILCSIILSHHqgpSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDR 266
Cdd:COG0666 211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAG---ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287


                .
gi 90186267 267 T 267
Cdd:COG0666 288 L 288
Ank_2 pfam12796
Ankyrin repeats (3 copies);
236-317 3.46e-15

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.30  E-value: 3.46e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   236 HIAAAAGFSDIIHELARvPECNLQALDVDDRTPLHWAAAAGKAECVQSLLElGMDSNLRDiNESTPLAYALYCGHTACVK 315
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ..
gi 90186267   316 LL 317
Cdd:pfam12796  79 LL 80
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
27-267 3.00e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 148.56  E-value: 3.00e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  27 DLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGW 106
Cdd:COG0666  53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267 107 LEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSniSEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGA 186
Cdd:COG0666 133 LEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAG--ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267 187 DPTLVDKDFKTALHWAVQSGNRILCSIILSHHqgpSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDR 266
Cdd:COG0666 211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAG---ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287


                .
gi 90186267 267 T 267
Cdd:COG0666 288 L 288
PHA03095 PHA03095
ankyrin-like protein; Provisional
 21-331 2.50e-23

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 103.57  E-value: 2.50e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   21 DSSEEVDLTMVYQAASNGDVNALTAVIREDPSIlECCDSEGCTPL---MHAVSGRQADTVKLLLKMGANINMQDAYGRTS 97
Cdd:PHA03095   8 DIIMEAALYDYLLNASNVTVEEVRRLLAAGADV-NFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTP 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   98 LCLATYLGWLEGCVSLL-RNGAKHNIPDKNGRLPLHA----ATAEPDMrlLTVLLQQsNISeINHQDNEGMTPLH-WAAF 171
Cdd:PHA03095  87 LHLYLYNATTLDVIKLLiKAGADVNAKDKVGRTPLHVylsgFNINPKV--IRLLLRK-GAD-VNALDLYGMTPLAvLLKS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  172 HNQPQHT-QMLLKKGADPTLVDKDFKTALHWAVQS---GNRILCSIIlSHHQGPSIINyddESGKTCVHIAAAAGF---S 244
Cdd:PHA03095 163 RNANVELlRLLIDAGADVYAVDDRFRSLLHHHLQSfkpRARIVRELI-RAGCDPAATD---MLGNTPLHSMATGSSckrS 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  245 DIIHELARVPECNlqALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSqesrte 324
Cdd:PHA03095 239 LVLPLLIAGISIN--ARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAAL------ 310


                 ....*..
gi 90186267  325 PTRPPPS 331
Cdd:PHA03095 311 AKNPSAE 317
Ank_2 pfam12796
Ankyrin repeats (3 copies);
199-295 4.43e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.61  E-value: 4.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   199 LHWAVQSGNRILCSIILSHHQGPsiiNYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQaldVDDRTPLHWAAAAGKA 278
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADA---NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHL 74

                          90
                  ....*....|....*..
gi 90186267   279 ECVQSLLELGMDSNLRD 295
Cdd:pfam12796  75 EIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
236-317 3.46e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.30  E-value: 3.46e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   236 HIAAAAGFSDIIHELARvPECNLQALDVDDRTPLHWAAAAGKAECVQSLLElGMDSNLRDiNESTPLAYALYCGHTACVK 315
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ..
gi 90186267   316 LL 317
Cdd:pfam12796  79 LL 80
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 227-322 5.16e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 49.48  E-value: 5.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  227 DDESGKTCVHIAAAAGFSDIIHELARVpecNLQAlDVDD---RTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLA 303
Cdd:PLN03192 521 DDPNMASNLLTVASTGNAALLEELLKA---KLDP-DIGDskgRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALW 596

                         90
                 ....*....|....*....
gi 90186267  304 YALYCGHTACVKLLSQESR 322
Cdd:PLN03192 597 NAISAKHHKIFRILYHFAS 615
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 60-89 1.57e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.80  E-value: 1.57e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 90186267     60 EGCTPLMHAVSGRQADTVKLLLKMGANINM 89
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 264-293 1.15e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 1.15e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 90186267    264 DDRTPLHWAAAAGKAECVQSLLELGMDSNL 293
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 12-184 7.13e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.23  E-value: 7.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  12 PSVFDQQRGDSSEevdlTMVYQAASNGDVNALTAVIREDPS-ILECCDSE---GCTPLMHAVSGRQADTVKLLLKMGANI 87
Cdd:cd22192  40 PSCDLFQRGALGE----TALHVAALYDNLEAAVVLMEAAPElVNEPMTSDlyqGETALHIAVVNQNLNLVRELIARGADV 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  88 NMQDA--------------YGRTSLCLATYLGwLEGCVSLL-RNGAKHNIPDKNGRLPLHAATAEPDMRLLT----VLLQ 148
Cdd:cd22192 116 VSPRAtgtffrpgpknliyYGEHPLSFAACVG-NEEIVRLLiEHGADIRAQDSLGNTVLHILVLQPNKTFACqmydLILS 194

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 90186267 149 Q---SNISEINH-QDNEGMTPLHWAAFHNQPQHTQMLLKK 184
Cdd:cd22192 195 YdkeDDLQPLDLvPNNQGLTPFKLAAKEGNIVMFQHLVQK 234
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
27-267 3.00e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 148.56  E-value: 3.00e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  27 DLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGW 106
Cdd:COG0666  53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267 107 LEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSniSEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGA 186
Cdd:COG0666 133 LEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAG--ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267 187 DPTLVDKDFKTALHWAVQSGNRILCSIILSHHqgpSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDR 266
Cdd:COG0666 211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAG---ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287


                .
gi 90186267 267 T 267
Cdd:COG0666 288 L 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
58-302 4.58e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.40  E-value: 4.58e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  58 DSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAE 137
Cdd:COG0666  51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267 138 PDMRLLTVLLQqsNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSH 217
Cdd:COG0666 131 GNLEIVKLLLE--AGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267 218 HqgpSIINYDDESGKTCVHIAAAAGFSDIIHELARVPEcNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDIN 297
Cdd:COG0666 209 G---ADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA-DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284


                ....*
gi 90186267 298 ESTPL 302
Cdd:COG0666 285 LLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
77-317 3.26e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.92  E-value: 3.26e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  77 VKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNisEIN 156
Cdd:COG0666   4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGA--DIN 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267 157 HQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHhqGPSiINYDDESGKTCVH 236
Cdd:COG0666  82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA--GAD-VNAQDNDGNTPLH 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267 237 IAAAAGFSDIIHEL----ArvpecNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTA 312
Cdd:COG0666 159 LAAANGNLEIVKLLleagA-----DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233


                ....*
gi 90186267 313 CVKLL 317
Cdd:COG0666 234 IVKLL 238
PHA03095 PHA03095
ankyrin-like protein; Provisional
 21-331 2.50e-23

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 103.57  E-value: 2.50e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   21 DSSEEVDLTMVYQAASNGDVNALTAVIREDPSIlECCDSEGCTPL---MHAVSGRQADTVKLLLKMGANINMQDAYGRTS 97
Cdd:PHA03095   8 DIIMEAALYDYLLNASNVTVEEVRRLLAAGADV-NFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTP 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   98 LCLATYLGWLEGCVSLL-RNGAKHNIPDKNGRLPLHA----ATAEPDMrlLTVLLQQsNISeINHQDNEGMTPLH-WAAF 171
Cdd:PHA03095  87 LHLYLYNATTLDVIKLLiKAGADVNAKDKVGRTPLHVylsgFNINPKV--IRLLLRK-GAD-VNALDLYGMTPLAvLLKS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  172 HNQPQHT-QMLLKKGADPTLVDKDFKTALHWAVQS---GNRILCSIIlSHHQGPSIINyddESGKTCVHIAAAAGF---S 244
Cdd:PHA03095 163 RNANVELlRLLIDAGADVYAVDDRFRSLLHHHLQSfkpRARIVRELI-RAGCDPAATD---MLGNTPLHSMATGSSckrS 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  245 DIIHELARVPECNlqALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSqesrte 324
Cdd:PHA03095 239 LVLPLLIAGISIN--ARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAAL------ 310


                 ....*..
gi 90186267  325 PTRPPPS 331
Cdd:PHA03095 311 AKNPSAE 317
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 68-223 6.50e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 83.18  E-value: 6.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   68 AVSGRQADTVKLLLKMGANINMQDAYGRTSL--CLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATA--EPDMRLL 143
Cdd:PHA03100  80 YNLTDVKEIVKLLLEYGANVNAPDNNGITPLlyAISKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLEsnKIDLKIL 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  144 TVLLQQ--------------SNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRI 209
Cdd:PHA03100 160 KLLIDKgvdinaknrvnyllSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKE 239

                        170
                 ....*....|....
gi 90186267  210 LCSIILSHhqGPSI 223
Cdd:PHA03100 240 IFKLLLNN--GPSI 251
Ank_2 pfam12796
Ankyrin repeats (3 copies);
199-295 4.43e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.61  E-value: 4.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   199 LHWAVQSGNRILCSIILSHHQGPsiiNYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQaldVDDRTPLHWAAAAGKA 278
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADA---NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHL 74

                          90
                  ....*....|....*..
gi 90186267   279 ECVQSLLELGMDSNLRD 295
Cdd:pfam12796  75 EIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
236-317 3.46e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.30  E-value: 3.46e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   236 HIAAAAGFSDIIHELARvPECNLQALDVDDRTPLHWAAAAGKAECVQSLLElGMDSNLRDiNESTPLAYALYCGHTACVK 315
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ..
gi 90186267   316 LL 317
Cdd:pfam12796  79 LL 80
Ank_2 pfam12796
Ankyrin repeats (3 copies);
65-192 4.68e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.92  E-value: 4.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267    65 LMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEgCVSLLrngAKHNIPDKngrlplhaataepdmrllt 144
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLE-IVKLL---LEHADVNL------------------- 57

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 90186267   145 vllqqsniseinhqDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVD 192
Cdd:pfam12796  58 --------------KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 62-317 6.77e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 77.01  E-value: 6.77e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   62 CTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLclatylgwlegcvSLLRNgAKHNIPDkngrlplhaataepDMR 141
Cdd:PHA03100  36 VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPL-------------HYLSN-IKYNLTD--------------VKE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  142 LLTVLLQqsNISEINHQDNEGMTPLHWAAFH--NQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRIL--CSIILSH 217
Cdd:PHA03100  88 IVKLLLE--YGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkiLKLLIDK 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  218 hqGPSI-----INYDDESGktcVHIaaaagfsDIIhelarvpecnlqalDVDDRTPLHWAAAAGKAECVQSLLELGMDSN 292
Cdd:PHA03100 166 --GVDInaknrVNYLLSYG---VPI-------NIK--------------DVYGFTPLHYAVYNNNPEFVKYLLDLGANPN 219

                        250       260
                 ....*....|....*....|....*
gi 90186267  293 LRDINESTPLAYALYCGHTACVKLL 317
Cdd:PHA03100 220 LVNKYGDTPLHIAILNNNKEIFKLL 244
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 37-306 5.24e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 74.61  E-value: 5.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   37 NGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLG-------WLEG 109
Cdd:PHA02874  11 SGDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGahdiiklLIDN 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  110 CV----------------SLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSniSEINHQDNEGMTPLHWAAFHN 173
Cdd:PHA02874  91 GVdtsilpipciekdmikTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYG--ADVNIEDDNGCYPIHIAIKHN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  174 QPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHhqGPSIINyDDESGKTCVHIAaaagfsdIIHELARV 253
Cdd:PHA02874 169 FFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDH--GNHIMN-KCKNGFTPLHNA-------IIHNRSAI 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 90186267  254 P----ECNLQALDVDDRTPLHWA-AAAGKAECVQSLLELGMDSNLRDINESTPLAYAL 306
Cdd:PHA02874 239 EllinNASINDQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIKDNKGENPIDTAF 296
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 11-305 4.69e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 72.02  E-value: 4.69e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   11 TPSVFDQQRGDSsEEVDLTMVYQAasngDVNALTAvirEDPSILECcdsegctplmhAVSGRQADTVKLLLKMGANINMQ 90
Cdd:PHA02876 180 TPIHYAAERGNA-KMVNLLLSYGA----DVNIIAL---DDLSVLEC-----------AVDSKNIDTIKAIIDNRSNINKN 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   91 DaygrTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDM-RLLTVLLQQSniSEINHQDNEGMTPLHWA 169
Cdd:PHA02876 241 D----LSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLsRLVPKLLERG--ADVNAKNIKGETPLYLM 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  170 AFHN-QPQHTQMLLKKGADPTLVDKDFKTALHWAvQSGNRILCSIILSHHQGPSIiNYDDESGKTCVHIAAAAGFSDIIH 248
Cdd:PHA02876 315 AKNGyDTENIRTLIMLGADVNAADRLYITPLHQA-STLDRNKDIVITLLELGANV-NARDYCDKTPIHYAAVRNNVVIIN 392

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 90186267  249 ELARVpECNLQALDVDDRTPLHWA-AAAGKAECVQSLLELGMDSNLRDINESTPLAYA 305
Cdd:PHA02876 393 TLLDY-GADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYA 449
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 65-293 1.67e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 66.55  E-value: 1.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   65 LMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLT 144
Cdd:PHA02875   6 LCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  145 VLLQQSN-ISEINHQDneGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHqgpSI 223
Cdd:PHA02875  86 ELLDLGKfADDVFYKD--GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHK---AC 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 90186267  224 INYDDESGKTCVHIAAAAGFSDIIHELARvPECNLQALDVD-DRTPLHWAAAAGKAECVQSLLELGMDSNL 293
Cdd:PHA02875 161 LDIEDCCGCTPLIIAMAKGDIAICKMLLD-SGANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRGADCNI 230
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 63-317 5.38e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 65.47  E-value: 5.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   63 TPLMHAVSGRQ-ADTVKLLLKMGANINMQDAYGRTSLCLATYLGW-LEGCVSLLRNGAKHNIPDKNGRLPLH-AATAEPD 139
Cdd:PHA02876 275 TPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHqASTLDRN 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  140 MRLLTVLLQQSniSEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILcsiilshhq 219
Cdd:PHA02876 355 KDIVITLLELG--ANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYM--------- 423

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  220 gpsiinyddeSGKTCVHIAAaagfsdiihelarvpecNLQALDVDDRTPLHWAAAAG-KAECVQSLLELGMDSNLRDINE 298
Cdd:PHA02876 424 ----------SVKTLIDRGA-----------------NVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQN 476

                        250
                 ....*....|....*....
gi 90186267  299 STPLAYALycGHTACVKLL 317
Cdd:PHA02876 477 QYPLLIAL--EYHGIVNIL 493
Ank_2 pfam12796
Ankyrin repeats (3 copies);
269-317 1.01e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.59  E-value: 1.01e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 90186267   269 LHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL 49
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 73-225 1.14e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 64.13  E-value: 1.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   73 QADTVKLLLKMGANINMQDAY-GRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQqsN 151
Cdd:PHA02878 146 EAEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLE--N 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  152 ISEINHQDNEGMTPLHWA------------------------------AFH---NQPQHTQMLLKKGADPTLVDKDFKTA 198
Cdd:PHA02878 224 GASTDARDKCGNTPLHISvgyckdydilklllehgvdvnaksyilgltALHssiKSERKLKLLLEYGADINSLNSYKLTP 303

                        170       180       190
                 ....*....|....*....|....*....|...
gi 90186267  199 LHWAVQS------GNRILCSIILSHHQGPSIIN 225
Cdd:PHA02878 304 LSSAVKQylciniGRILISNICLLKRIKPDIKN 336
Ank_2 pfam12796
Ankyrin repeats (3 copies);
131-217 2.22e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.43  E-value: 2.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   131 LHAATAEPDMRLLTVLLQqsNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKgADPTLVDKDfKTALHWAVQSGNRIL 210
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE--NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEI 76


                  ....*..
gi 90186267   211 CSIILSH 217
Cdd:pfam12796  77 VKLLLEK 83
Ank_4 pfam13637
Ankyrin repeats (many copies);
266-317 3.87e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.74  E-value: 3.87e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 90186267   266 RTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 31-191 1.96e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 60.00  E-value: 1.96e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   31 VYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGC 110
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGI 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  111 VSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQ-SNISEINHqdNEGMTPLHWAAFHNQPQHTQMLLKKGADPT 189
Cdd:PHA02875 152 ELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSgANIDYFGK--NGCVAALCYAIENNKIDIVRLFIKRGADCN 229


                 ..
gi 90186267  190 LV 191
Cdd:PHA02875 230 IM 231
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 62-318 9.62e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 57.97  E-value: 9.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   62 CTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSL---CLA--------------------TYLGWLEGC-------- 110
Cdd:PHA02878  38 FIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLhiiCKEpnklgmkemirsinkcsvfyTLVAIKDAFnnrnveif 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  111 VSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSniSEINHQD-NEGMTPLHWAAFHNQPQHTQMLLKKGADPT 189
Cdd:PHA02878 118 KIILTNRYKNIQTIDLVYIDKKSKDDIIEAEITKLLLSYG--ADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVN 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  190 LVDKDFKTALHWAVQSGNRILCSIILshhQGPSIINYDDESGKTCVHIAAAAGFS-DIIHELARVPEC-NLQAlDVDDRT 267
Cdd:PHA02878 196 IPDKTNNSPLHHAVKHYNKPIVHILL---ENGASTDARDKCGNTPLHISVGYCKDyDILKLLLEHGVDvNAKS-YILGLT 271

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 90186267  268 PLHwaAAAGKAECVQSLLELGMDSNLRDINESTPLAYAL--YCGHTACVKLLS 318
Cdd:PHA02878 272 ALH--SSIKSERKLKLLLEYGADINSLNSYKLTPLSSAVkqYLCINIGRILIS 322
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 23-302 1.10e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 58.15  E-value: 1.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   23 SEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEgCTPLMHAV--SGRQADTVkLLLKMGANINMQDAYgrTSLCL 100
Cdd:PHA02876  37 NESIPFTAIHQALQLRQIDIVEEIIQQNPELIYITDHK-CHSTLHTIciIPNVMDIV-ISLTLDCDIILDIKY--ASIIL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  101 ATY-LGwlEGCVSLLRNGAKHN------IPDKNGRLPLHAATAEPDMRLLTVLLQQSNIsEINHQDNEGMTPLHWAAFHN 173
Cdd:PHA02876 113 NKHkLD--EACIHILKEAISGNdihydkINESIEYMKLIKERIQQDELLIAEMLLEGGA-DVNAKDIYCITPIHYAAERG 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  174 QPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHqgpSIINYDDESGKTCVH--------IAAAAGFSd 245
Cdd:PHA02876 190 NAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNR---SNINKNDLSLLKAIRnedletslLLYDAGFS- 265

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 90186267  246 iihelarvpecnLQALDVDDRTPLHWAAAAGK-AECVQSLLELGMDSNLRDINESTPL 302
Cdd:PHA02876 266 ------------VNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPL 311
Ank_5 pfam13857
Ankyrin repeats (many copies);
256-305 9.05e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 48.88  E-value: 9.05e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 90186267   256 CNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYA 305
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_2 pfam12796
Ankyrin repeats (3 copies);
21-91 1.18e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 49.73  E-value: 1.18e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 90186267    21 DSSEEVDLTMVYQAASNGDVNALTAVIREDPSileCCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQD 91
Cdd:pfam12796  24 NLQDKNGRTALHLAAKNGHLEIVKLLLEHADV---NLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_4 pfam13637
Ankyrin repeats (many copies);
162-207 3.53e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.27  E-value: 3.53e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 90186267   162 GMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN 207
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGN 46
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 130-219 1.09e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.82  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  130 PLHAATAEPDM-----RLLTVLLQQSNIS--------------EINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTL 190
Cdd:PTZ00322  64 PDHNLTTEEVIdpvvaHMLTVELCQLAASgdavgarilltggaDPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTL 143

                         90       100
                 ....*....|....*....|....*....
gi 90186267  191 VDKDFKTALHWAVQSGNRILCSIILSHHQ 219
Cdd:PTZ00322 144 LDKDGKTPLELAEENGFREVVQLLSRHSQ 172
Ank_4 pfam13637
Ankyrin repeats (many copies);
127-182 1.48e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.34  E-value: 1.48e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 90186267   127 GRLPLHAATAEPDMRLLTVLLQQSNisEINHQDNEGMTPLHWAAFHNQPQHTQMLL 182
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGA--DINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
47-101 1.84e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.42  E-value: 1.84e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 90186267    47 IREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLA 101
Cdd:pfam13857   2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02946 PHA02946
ankyin-like protein; Provisional
 156-315 2.57e-06

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 50.05  E-value: 2.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  156 NHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGktCV 235
Cdd:PHA02946  66 NETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIERINLLVQYGAKINNSVDEEG--CG 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  236 HIAAAAGFSDIIheLARVPECNLQALDVD----DRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLayalycgHT 311
Cdd:PHA02946 144 PLLACTDPSERV--FKKIMSIGFEARIVDkfgkNHIHRHLMSDNPKASTISWMMKLGISPSKPDHDGNTPL-------HI 214


                 ....
gi 90186267  312 ACVK 315
Cdd:PHA02946 215 VCSK 218
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 227-322 5.16e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 49.48  E-value: 5.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  227 DDESGKTCVHIAAAAGFSDIIHELARVpecNLQAlDVDD---RTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLA 303
Cdd:PLN03192 521 DDPNMASNLLTVASTGNAALLEELLKA---KLDP-DIGDskgRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALW 596

                         90
                 ....*....|....*....
gi 90186267  304 YALYCGHTACVKLLSQESR 322
Cdd:PLN03192 597 NAISAKHHKIFRILYHFAS 615
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 156-317 6.32e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.83  E-value: 6.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  156 NHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDesGKTCV 235
Cdd:PHA02875  29 NFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKD--GMTPL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  236 HIAAAAGFSDIIHEL-ARVPECNLQalDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACV 314
Cdd:PHA02875 107 HLATILKKLDIMKLLiARGADPDIP--NTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAIC 184


                 ...
gi 90186267  315 KLL 317
Cdd:PHA02875 185 KML 187
Ank_5 pfam13857
Ankyrin repeats (many copies);
146-202 6.51e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.87  E-value: 6.51e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 90186267   146 LLQQSNISeINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWA 202
Cdd:pfam13857   1 LLEHGPID-LNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 20-194 6.56e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 49.48  E-value: 6.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   20 GDSSEE-VDLTM---VYQAASNGDVNALTAVIR--EDPSIlecCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAY 93
Cdd:PLN03192 514 GDNGGEhDDPNMasnLLTVASTGNAALLEELLKakLDPDI---GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDAN 590

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   94 GRTSLCLATYLGWLEgCVSLLRNGAKHNIPDKNGRLpLHAATAEPDMRLLTVLLQQSniSEINHQDNEGMTPLHWAAFHN 173
Cdd:PLN03192 591 GNTALWNAISAKHHK-IFRILYHFASISDPHAAGDL-LCTAAKRNDLTAMKELLKQG--LNVDSEDHQGATALQVAMAED 666

                        170       180
                 ....*....|....*....|.
gi 90186267  174 QPQHTQMLLKKGADPTLVDKD 194
Cdd:PLN03192 667 HVDMVRLLIMNGADVDKANTD 687
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 60-89 1.57e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.80  E-value: 1.57e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 90186267     60 EGCTPLMHAVSGRQADTVKLLLKMGANINM 89
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 181-317 4.96e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 46.40  E-value: 4.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  181 LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGpsiINYDDESGKTCVHIAAAAGFS---DIIHELARVPECN 257
Cdd:PLN03192 544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACN---VHIRDANGNTALWNAISAKHHkifRILYHFASISDPH 620

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  258 LqALDVddrtpLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
Cdd:PLN03192 621 A-AGDL-----LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLL 674
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 262-336 5.30e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.43  E-value: 5.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  262 DVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQ--------ESRTEP---TRPPP 330
Cdd:PTZ00322 112 DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRhsqchfelGANAKPdsfTGKPP 191


                 ....*.
gi 90186267  331 SQSSRP 336
Cdd:PTZ00322 192 SLEDSP 197
PHA02798 PHA02798
ankyrin-like protein; Provisional
 75-214 7.03e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 45.60  E-value: 7.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   75 DTVKLLLKMGANINMQDAYGRTSLC-----LATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAataepdmrlltvLLQQ 149
Cdd:PHA02798  52 DIVKLFINLGANVNGLDNEYSTPLCtilsnIKDYKHMLDIVKILIENGADINKKNSDGETPLYC------------LLSN 119

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 90186267  150 SNIseinhqdnegmtplhwaafhNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSII 214
Cdd:PHA02798 120 GYI--------------------NNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHIDIEII 164
PHA03095 PHA03095
ankyrin-like protein; Provisional
 58-201 7.82e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.40  E-value: 7.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   58 DSEGCTPL-MHAVSGR-QADTVKLLLKMGANINMQDAYGRTSL-CLATYLGWLEGCVS-LLRNGAKHNIPDKNGRLPLHA 133
Cdd:PHA03095 184 DDRFRSLLhHHLQSFKpRARIVRELIRAGCDPAATDMLGNTPLhSMATGSSCKRSLVLpLLIAGISINARNRYGQTPLHY 263

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 90186267  134 ATAEPDMRLLTVLLQQSniSEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHW 201
Cdd:PHA03095 264 AAVFNNPRACRRLIALG--ADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVAATLNTASVA 329
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 60-91 8.20e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 8.20e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 90186267    60 EGCTPLMHAV-SGRQADTVKLLLKMGANINMQD 91
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 161-193 8.28e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 8.28e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 90186267   161 EGMTPLHWAAFH-NQPQHTQMLLKKGADPTLVDK 193
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 161-190 2.61e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.34  E-value: 2.61e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 90186267    161 EGMTPLHWAAFHNQPQHTQMLLKKGADPTL 190
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 264-295 3.31e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.42  E-value: 3.31e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 90186267   264 DDRTPLHWAAA-AGKAECVQSLLELGMDSNLRD 295
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 161-188 4.35e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.01  E-value: 4.35e-04
                          10        20
                  ....*....|....*....|....*...
gi 90186267   161 EGMTPLHWAAFHNQPQHTQMLLKKGADP 188
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 22-150 6.30e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 42.34  E-value: 6.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   22 SSEEVDLTMVYQAASNG-DVNALTAV---IREDPSILECcDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTS 97
Cdd:PHA03100 150 ESNKIDLKILKLLIDKGvDINAKNRVnylLSYGVPINIK-DVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTP 228

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 90186267   98 LCLATYLGWLEGCVSLLRNGAkhNIPDKNGRLPLHAATaEPDMRLLTVLLQQS 150
Cdd:PHA03100 229 LHIAILNNNKEIFKLLLNNGP--SIKTIIETLLYFKDK-DLNTITKIKMLKKS 278
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 60-89 1.02e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.85  E-value: 1.02e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 90186267    60 EGCTPLMHAVSGRQADTVKLLLKMGANINM 89
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 179-260 1.05e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.19  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  179 QMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIInydDESGKTCVHIAAAAGFSDIIHELARVPECNL 258
Cdd:PTZ00322  99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLL---DKDGKTPLELAEENGFREVVQLLSRHSQCHF 175


                 ..
gi 90186267  259 QA 260
Cdd:PTZ00322 176 EL 177
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 264-293 1.15e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 1.15e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 90186267    264 DDRTPLHWAAAAGKAECVQSLLELGMDSNL 293
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
63-114 1.45e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 1.45e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 90186267    63 TPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEgCVSLL 114
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVE-VLKLL 53
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 22-156 1.66e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.42  E-value: 1.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267   22 SSEEVDLTMVYQAASNGDVnaltavireDPSILECCDSEGCTplmHAVSGrqaDTV--KLLLKMGANINMQDAYGRTSLC 99
Cdd:PTZ00322  56 ATENKDATPDHNLTTEEVI---------DPVVAHMLTVELCQ---LAASG---DAVgaRILLTGGADPNCRDYDGRTPLH 120

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 90186267  100 LATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAAtAEPDMRLLTVLLQQSNISEIN 156
Cdd:PTZ00322 121 IACANGHVQVVRVLLEFGADPTLLDKDGKTPLELA-EENGFREVVQLLSRHSQCHFE 176
PHA02791 PHA02791
ankyrin-like protein; Provisional
 124-207 2.28e-03

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 40.41  E-value: 2.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  124 DKNGRLPLHAATAEPDMRLLTVLLQQSNISeiNHQDNEgmTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAV 203
Cdd:PHA02791  27 DVHGHSALYYAIADNNVRLVCTLLNAGALK--NLLENE--FPLHQAATLEDTKIVKILLFSGMDDSQFDDKGNTALYYAV 102


                 ....
gi 90186267  204 QSGN 207
Cdd:PHA02791 103 DSGN 106
Ank_4 pfam13637
Ankyrin repeats (many copies);
197-250 3.57e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.10  E-value: 3.57e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 90186267   197 TALHWAVQSGNRILCSIILSHhqgPSIINYDDESGKTCVHIAAAAGFSDIIHEL 250
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEK---GADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 264-292 6.07e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.54  E-value: 6.07e-03
                          10        20
                  ....*....|....*....|....*....
gi 90186267   264 DDRTPLHWAAAAGKAECVQSLLELGMDSN 292
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 181-317 6.21e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 39.20  E-value: 6.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  181 LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPsiiNYDDESGKTCVHIAAAAGFSDIIHELArvpECNLQA 260
Cdd:PHA02875  21 LLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIP---DVKYPDIESELHDAVEEGDVKAVEELL---DLGKFA 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  261 LDV---DDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
Cdd:PHA02875  95 DDVfykDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELL 154
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 12-184 7.13e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.23  E-value: 7.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  12 PSVFDQQRGDSSEevdlTMVYQAASNGDVNALTAVIREDPS-ILECCDSE---GCTPLMHAVSGRQADTVKLLLKMGANI 87
Cdd:cd22192  40 PSCDLFQRGALGE----TALHVAALYDNLEAAVVLMEAAPElVNEPMTSDlyqGETALHIAVVNQNLNLVRELIARGADV 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90186267  88 NMQDA--------------YGRTSLCLATYLGwLEGCVSLL-RNGAKHNIPDKNGRLPLHAATAEPDMRLLT----VLLQ 148
Cdd:cd22192 116 VSPRAtgtffrpgpknliyYGEHPLSFAACVG-NEEIVRLLiEHGADIRAQDSLGNTVLHILVLQPNKTFACqmydLILS 194

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 90186267 149 Q---SNISEINH-QDNEGMTPLHWAAFHNQPQHTQMLLKK 184
Cdd:cd22192 195 YdkeDDLQPLDLvPNNQGLTPFKLAAKEGNIVMFQHLVQK 234
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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