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Conserved domains on  [gi|56119214|ref|NP_078987|]
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GTPase IMAP family member 6 isoform 1 [Homo sapiens]

Protein Classification

GTPase IMAP family protein( domain architecture ID 10111261)

GTPase immunity-associated protein (IMAP) family protein may function as regulator of lymphocyte survival and homeostasis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 41-241 1.71e-102

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


:

Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 297.52  E-value: 1.71e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214  41 LRLILMGKTGSGKSATGNSILGRDVFESKLSTRPVTKTSQRRSREWAGKELEVIDTPNILSPQVSPE-VADAICQAIVLS 119
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEqLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214 120 APGPHAVLLVTQLGRFTDEDQQVVRRLQEVFGVGVLGHTILVFTRKEDLAGGSLEDYVREtNNQALAWLDVTLARRHCGF 199
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLED-SCEALKRLLEKCGGRYVAF 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 56119214 200 NNRAQGEEQEAQLRELMEKVEAIMWENEGDYYSNKAYQYTQQ 241
Cdd:cd01852 160 NNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAEE 201
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 41-241 1.71e-102

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 297.52  E-value: 1.71e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214  41 LRLILMGKTGSGKSATGNSILGRDVFESKLSTRPVTKTSQRRSREWAGKELEVIDTPNILSPQVSPE-VADAICQAIVLS 119
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEqLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214 120 APGPHAVLLVTQLGRFTDEDQQVVRRLQEVFGVGVLGHTILVFTRKEDLAGGSLEDYVREtNNQALAWLDVTLARRHCGF 199
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLED-SCEALKRLLEKCGGRYVAF 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 56119214 200 NNRAQGEEQEAQLRELMEKVEAIMWENEGDYYSNKAYQYTQQ 241
Cdd:cd01852 160 NNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAEE 201
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 41-249 7.29e-93

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 273.33  E-value: 7.29e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214    41 LRLILMGKTGSGKSATGNSILGRDVFESKLSTRPVTKTSQRRSREWAGKELEVIDTPNILSPQVSpevADAICQAIV--- 117
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVS---NDFISKEIIrcl 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214   118 -LSAPGPHAVLLVTQLGRFTDEDQQVVRRLQEVFGVGVLGHTILVFTRKEDLAGGSLEDYVRETNNQALAWLDVTlarrh 196
Cdd:pfam04548  78 lLAEPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDGCPEFLKEVLRT----- 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 56119214   197 cgfnnrAQGEEQEAQLRELMEKVEAIMWENEGDYYSNKAYQYTQQN-FRLKELQ 249
Cdd:pfam04548 153 ------ADGEEKEEQVQQLLALVEAIVKENGGKPYTNDLYEKIKEEgERLREQQ 200
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
 11-163 2.27e-11

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 63.38  E-value: 2.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214    11 QENPPEelSQDPVLELSGGLREKEQKTprrLRLILMGKTGSGKSATGNSILGRDV-----FESKlSTRPVTKtsqrrSRE 85
Cdd:TIGR00991  14 QQFPPA--TQTKLLELLGKLKEEDVSS---LTILVMGKGGVGKSSTVNSIIGERIatvsaFQSE-GLRPMMV-----SRT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214    86 WAGKELEVIDTPNILSPQVSPEVADAICQAIVLSAPgPHAVLLVTQLG--RFTDEDQQVVRRLQEVFGVGVLGHTILVFT 163
Cdd:TIGR00991  83 RAGFTLNIIDTPGLIEGGYINDQAVNIIKRFLLGKT-IDVLLYVDRLDayRVDTLDGQVIRAITDSFGKDIWRKSLVVLT 161
YeeP COG3596
Predicted GTPase [General function prediction only];
31-148 4.28e-08

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 53.62  E-value: 4.28e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214  31 REKEQKTPRRLRLILMGKTGSGKSATGNSILGRDVFESKLsTRPVTKTSQR-RSREWAGKELEVIDTPNIlspqVSPEVA 109
Cdd:COG3596  30 LERLLVELPPPVIALVGKTGAGKSSLINALFGAEVAEVGV-GRPCTREIQRyRLESDGLPGLVLLDTPGL----GEVNER 104

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 56119214 110 DAICQAIVLSAPGPHAVLLVTQ-LGRFTDEDQQVVRRLQE 148
Cdd:COG3596 105 DREYRELRELLPEADLILWVVKaDDRALATDEEFLQALRA 144
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 41-241 1.71e-102

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 297.52  E-value: 1.71e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214  41 LRLILMGKTGSGKSATGNSILGRDVFESKLSTRPVTKTSQRRSREWAGKELEVIDTPNILSPQVSPE-VADAICQAIVLS 119
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEqLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214 120 APGPHAVLLVTQLGRFTDEDQQVVRRLQEVFGVGVLGHTILVFTRKEDLAGGSLEDYVREtNNQALAWLDVTLARRHCGF 199
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLED-SCEALKRLLEKCGGRYVAF 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 56119214 200 NNRAQGEEQEAQLRELMEKVEAIMWENEGDYYSNKAYQYTQQ 241
Cdd:cd01852 160 NNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAEE 201
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 41-249 7.29e-93

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 273.33  E-value: 7.29e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214    41 LRLILMGKTGSGKSATGNSILGRDVFESKLSTRPVTKTSQRRSREWAGKELEVIDTPNILSPQVSpevADAICQAIV--- 117
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVS---NDFISKEIIrcl 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214   118 -LSAPGPHAVLLVTQLGRFTDEDQQVVRRLQEVFGVGVLGHTILVFTRKEDLAGGSLEDYVRETNNQALAWLDVTlarrh 196
Cdd:pfam04548  78 lLAEPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDGCPEFLKEVLRT----- 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 56119214   197 cgfnnrAQGEEQEAQLRELMEKVEAIMWENEGDYYSNKAYQYTQQN-FRLKELQ 249
Cdd:pfam04548 153 ------ADGEEKEEQVQQLLALVEAIVKENGGKPYTNDLYEKIKEEgERLREQQ 200
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
 24-163 1.73e-15

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 74.28  E-value: 1.73e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214  24 LELSGGLREKEQKTprrLRLILMGKTGSGKSATGNSILGrdvfESKLST---RPVTKTSQRRSREWAGKELEVIDTPNIL 100
Cdd:cd01853  18 HELEAKLKKELDFS---LTILVLGKTGVGKSSTINSIFG----ERKVSVsafQSETLRPREVSRTVDGFKLNIIDTPGLL 90

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56119214 101 sPQVSPEVADAICQAI--VLSAPGPHAVLLVTQLG--RFTDEDQQVVRRLQEVFGVGVLGHTILVFT 163
Cdd:cd01853  91 -ESQDQRVNRKILSIIkrFLKKKTIDVVLYVDRLDmyRVDNLDVPLLRAITDSFGPSIWRNAIVVLT 156
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
 11-163 2.27e-11

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 63.38  E-value: 2.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214    11 QENPPEelSQDPVLELSGGLREKEQKTprrLRLILMGKTGSGKSATGNSILGRDV-----FESKlSTRPVTKtsqrrSRE 85
Cdd:TIGR00991  14 QQFPPA--TQTKLLELLGKLKEEDVSS---LTILVMGKGGVGKSSTVNSIIGERIatvsaFQSE-GLRPMMV-----SRT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214    86 WAGKELEVIDTPNILSPQVSPEVADAICQAIVLSAPgPHAVLLVTQLG--RFTDEDQQVVRRLQEVFGVGVLGHTILVFT 163
Cdd:TIGR00991  83 RAGFTLNIIDTPGLIEGGYINDQAVNIIKRFLLGKT-IDVLLYVDRLDayRVDTLDGQVIRAITDSFGKDIWRKSLVVLT 161
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 45-177 2.44e-08

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 52.46  E-value: 2.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214  45 LMGKTGSGKSATGNSILGRDVFEsKLSTRPVTKTSQRRSREWAGKE--LEVIDTPNILSPQVSPEVADAIcqaivLSAPG 122
Cdd:cd00882   2 VVGRGGVGKSSLLNALLGGEVGE-VSDVPGTTRDPDVYVKELDKGKvkLVLVDTPGLDEFGGLGREELAR-----LLLRG 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56119214 123 PHAVLLVTQLGRFTDEDQQVVRRLQEVFGVGVlgHTILVFTrKEDLAGGSLEDYV 177
Cdd:cd00882  76 ADLILLVVDSTDRESEEDAKLLILRRLRKEGI--PIILVGN-KIDLLEEREVEEL 127
YeeP COG3596
Predicted GTPase [General function prediction only];
31-148 4.28e-08

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 53.62  E-value: 4.28e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214  31 REKEQKTPRRLRLILMGKTGSGKSATGNSILGRDVFESKLsTRPVTKTSQR-RSREWAGKELEVIDTPNIlspqVSPEVA 109
Cdd:COG3596  30 LERLLVELPPPVIALVGKTGAGKSSLINALFGAEVAEVGV-GRPCTREIQRyRLESDGLPGLVLLDTPGL----GEVNER 104

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 56119214 110 DAICQAIVLSAPGPHAVLLVTQ-LGRFTDEDQQVVRRLQE 148
Cdd:COG3596 105 DREYRELRELLPEADLILWVVKaDDRALATDEEFLQALRA 144
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 41-163 8.02e-06

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 47.25  E-value: 8.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214    41 LRLILMGKTGSGKSATGNSILGrdvfESKLST---RPVTKTSQRRSREWAGKELEVIDTPNILSP---QVSPEVADAICQ 114
Cdd:TIGR00993 119 LNILVLGKSGVGKSATINSIFG----EVKFSTdafGMGTTSVQEIEGLVQGVKIRVIDTPGLKSSasdQSKNEKILSSVK 194

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 56119214   115 AIVLSAPgPHAVLLVTQLGRFTDE--DQQVVRRLQEVFGVGVLGHTILVFT 163
Cdd:TIGR00993 195 KFIKKNP-PDIVLYVDRLDMQTRDsnDLPLLRTITDVLGPSIWFNAIVTLT 244
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
 47-148 7.88e-04

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 39.15  E-value: 7.88e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214  47 GKTGSGKSATGNSILGRDVFESklSTRP-VTKTSQRRSREWAGK-ELEVIDTPNILSPQVS-PEVADAICQAIVLSapgp 123
Cdd:cd00880   4 GRPNVGKSSLLNALLGQNVGIV--SPIPgTTRDPVRKEWELLPLgPVVLIDTPGLDEEGGLgRERVEEARQVADRA---- 77

                        90       100
                ....*....|....*....|....*
gi 56119214 124 HAVLLVTQLGRFTDEDQQVVRRLQE 148
Cdd:cd00880  78 DLVLLVVDSDLTPVEEEAKLGLLRE 102
YfjP cd11383
YfjP GTPase; The Era (E. coli Ras-like protein)-like YfjP subfamily includes several ...
 45-130 2.74e-03

YfjP GTPase; The Era (E. coli Ras-like protein)-like YfjP subfamily includes several uncharacterized bacterial GTPases that are similar to Era. They generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain.


Pssm-ID: 206743 [Multi-domain]  Cd Length: 140  Bit Score: 37.32  E-value: 2.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119214  45 LMGKTGSGKSATGNSILGRDVFESKlSTRPVTKTSQRRSREWAGKELEVIDTPNILSPQVSPEVADAICQAIVlsaPGPH 124
Cdd:cd11383   2 LMGKTGAGKSSLCNALFGTEVAAVG-DRRPTTRAAQAYVWQTGGDGLVLLDLPGVGERGRRDREYEELYRRLL---PEAD 77


                ....*.
gi 56119214 125 AVLLVT 130
Cdd:cd11383  78 LVLWLL 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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