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Conserved domains on  [gi|156139127|ref|NP_079218|]
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ATPase PAAT [Homo sapiens]

Protein Classification

DUF4506 domain-containing protein( domain architecture ID 10633141)

DUF4506 domain-containing protein similar to Homo sapiens ATPase PAAT, a novel ATPase and trans-regulator of mitochondrial ABC transporters, which is critically involved in the maintenance of mitochondrial homeostasis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAAT-like pfam14958
ATPase PAAT-like; This family is found in eukaryotes. It represents the ATPase protein ...
 59-198 1.07e-79

ATPase PAAT-like; This family is found in eukaryotes. It represents the ATPase protein associated with ABC transporters (PAAT) and related proteins. PAAT is formed of a nucleotide-binding domain (NBD)-like domain and a signal for intramitochondrial sorting. PAAT interacts with the mitochondrial inner membrane ABC proteins: ABCB7, ABCB8 and ABCB10. It is involved in maintenance of mitochondrial homeostasis and cell survival.


:

Pssm-ID: 464404  Cd Length: 141  Bit Score: 242.95  E-value: 1.07e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139127   59 VILKRNHNNKDENPCFLYLRCGPDGGEEIASIGILSSARNMEVYLG-EEYCGTSRGKNVCTVLDDSEHEKIILYKKNLKL 137
Cdd:pfam14958   1 VVLLSSNSEDDEEPCELTLQCKPRGGEEIVALGIVSSARNMEVYLGgEEYCGTSRGERVETVGDDSEEEKIRLYRKDLKL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 156139127  138 ESSTHACKIKLLSFGERQCVFISKVVVHMRSVFANSSTSSPALGSRIDLDKVQTIMESMGS 198
Cdd:pfam14958  81 ESSTAACELKLLSLGEKQCVYGSKLVVALRPNSATTQPSLPALGSRIDLQKVQTLLESMGS 141
 
Name Accession Description Interval E-value
PAAT-like pfam14958
ATPase PAAT-like; This family is found in eukaryotes. It represents the ATPase protein ...
 59-198 1.07e-79

ATPase PAAT-like; This family is found in eukaryotes. It represents the ATPase protein associated with ABC transporters (PAAT) and related proteins. PAAT is formed of a nucleotide-binding domain (NBD)-like domain and a signal for intramitochondrial sorting. PAAT interacts with the mitochondrial inner membrane ABC proteins: ABCB7, ABCB8 and ABCB10. It is involved in maintenance of mitochondrial homeostasis and cell survival.


Pssm-ID: 464404  Cd Length: 141  Bit Score: 242.95  E-value: 1.07e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139127   59 VILKRNHNNKDENPCFLYLRCGPDGGEEIASIGILSSARNMEVYLG-EEYCGTSRGKNVCTVLDDSEHEKIILYKKNLKL 137
Cdd:pfam14958   1 VVLLSSNSEDDEEPCELTLQCKPRGGEEIVALGIVSSARNMEVYLGgEEYCGTSRGERVETVGDDSEEEKIRLYRKDLKL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 156139127  138 ESSTHACKIKLLSFGERQCVFISKVVVHMRSVFANSSTSSPALGSRIDLDKVQTIMESMGS 198
Cdd:pfam14958  81 ESSTAACELKLLSLGEKQCVYGSKLVVALRPNSATTQPSLPALGSRIDLQKVQTLLESMGS 141
 
Name Accession Description Interval E-value
PAAT-like pfam14958
ATPase PAAT-like; This family is found in eukaryotes. It represents the ATPase protein ...
 59-198 1.07e-79

ATPase PAAT-like; This family is found in eukaryotes. It represents the ATPase protein associated with ABC transporters (PAAT) and related proteins. PAAT is formed of a nucleotide-binding domain (NBD)-like domain and a signal for intramitochondrial sorting. PAAT interacts with the mitochondrial inner membrane ABC proteins: ABCB7, ABCB8 and ABCB10. It is involved in maintenance of mitochondrial homeostasis and cell survival.


Pssm-ID: 464404  Cd Length: 141  Bit Score: 242.95  E-value: 1.07e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139127   59 VILKRNHNNKDENPCFLYLRCGPDGGEEIASIGILSSARNMEVYLG-EEYCGTSRGKNVCTVLDDSEHEKIILYKKNLKL 137
Cdd:pfam14958   1 VVLLSSNSEDDEEPCELTLQCKPRGGEEIVALGIVSSARNMEVYLGgEEYCGTSRGERVETVGDDSEEEKIRLYRKDLKL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 156139127  138 ESSTHACKIKLLSFGERQCVFISKVVVHMRSVFANSSTSSPALGSRIDLDKVQTIMESMGS 198
Cdd:pfam14958  81 ESSTAACELKLLSLGEKQCVYGSKLVVALRPNSATTQPSLPALGSRIDLQKVQTLLESMGS 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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