NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|21728372|ref|NP_079718|]
View 

dolichyl-phosphate beta-glucosyltransferase [Mus musculus]

Protein Classification

dolichyl-phosphate beta-glucosyltransferase( domain architecture ID 10135784)

dolichyl-phosphate beta-glucosyltransferase is a glycosyltransferase family 2 protein that catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate

CAZY:  GT2
EC:  2.4.1.117
Gene Ontology:  GO:0004581|GO:0006486
PubMed:  12200473|10521532|12691742|9445404
SCOP:  3000077

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 69-289 1.05e-123

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


:

Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 353.03  E-value: 1.05e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  69 VVVPSYNEEKRLPVMMDEALNYLEKRQKhdctFTYEVIVVDDGSEDQTSKVALKYCQKYGSDkVRVITLVRNRGKGGAVR 148
Cdd:cd04188   1 VVIPAYNEEKRLPPTLEEAVEYLEERPS----FSYEIIVVDDGSKDGTAEVARKLARKNPAL-IRVLTLPKNRGKGGAVR 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372 149 MGVFSSRGEKILMADADGATKFPDVEKLEKglsdlQPWPEQMAIACGSRAHLEKESIAQRSYFRTFLMYGFHFLVWFLCV 228
Cdd:cd04188  76 AGMLAARGDYILFADADLATPFEELEKLEE-----ALKTSGYDIAIGSRAHLASAAVVKRSWLRNLLGRGFNFLVRLLLG 150

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21728372 229 KGIRDTQCGFKLLTREAAARTFSSLHIERWAFDVELLYIAQCLQIPIAEVAVNWTEIEGSK 289
Cdd:cd04188 151 LGIKDTQCGFKLFTRDAARRLFPRLHLERWAFDVELLVLARRLGYPIEEVPVRWVEIPGSK 211
 
Name Accession Description Interval E-value
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 69-289 1.05e-123

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 353.03  E-value: 1.05e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  69 VVVPSYNEEKRLPVMMDEALNYLEKRQKhdctFTYEVIVVDDGSEDQTSKVALKYCQKYGSDkVRVITLVRNRGKGGAVR 148
Cdd:cd04188   1 VVIPAYNEEKRLPPTLEEAVEYLEERPS----FSYEIIVVDDGSKDGTAEVARKLARKNPAL-IRVLTLPKNRGKGGAVR 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372 149 MGVFSSRGEKILMADADGATKFPDVEKLEKglsdlQPWPEQMAIACGSRAHLEKESIAQRSYFRTFLMYGFHFLVWFLCV 228
Cdd:cd04188  76 AGMLAARGDYILFADADLATPFEELEKLEE-----ALKTSGYDIAIGSRAHLASAAVVKRSWLRNLLGRGFNFLVRLLLG 150

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21728372 229 KGIRDTQCGFKLLTREAAARTFSSLHIERWAFDVELLYIAQCLQIPIAEVAVNWTEIEGSK 289
Cdd:cd04188 151 LGIKDTQCGFKLFTRDAARRLFPRLHLERWAFDVELLVLARRLGYPIEEVPVRWVEIPGSK 211
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 66-318 2.87e-119

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 346.75  E-value: 2.87e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372   66 QLSVVVPSYNEEKRLPVMMDEALNYLEKRQKHDCTFTYEVIVVDDGSEDQTSKVALKYCQKYGSDKV--RVITLVRNRGK 143
Cdd:PTZ00260  71 DLSIVIPAYNEEDRLPKMLKETIKYLESRSRKDPKFKYEIIIVNDGSKDKTLKVAKDFWRQNINPNIdiRLLSLLRNKGK 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  144 GGAVRMGVFSSRGEKILMADADGATKFPDVEKLEKGLsdLQPWPEQMAIACGSRAHLEK-ESIAQRSYFRTFLMYGFHFL 222
Cdd:PTZ00260 151 GGAVRIGMLASRGKYILMVDADGATDIDDFDKLEDIM--LKIEQNGLGIVFGSRNHLVDsDVVAKRKWYRNILMYGFHFI 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  223 VWFLCVKGIRDTQCGFKLLTREAAARTFSSLHIERWAFDVELLYIAQCLQIPIAEVAVNWTEIEGSKLVPFWSWLQMGKD 302
Cdd:PTZ00260 229 VNTICGTNLKDTQCGFKLFTRETARIIFPSLHLERWAFDIEIVMIAQKLNLPIAEVPVNWTEVEGSKLNVISASIQMARD 308

                        250
                 ....*....|....*.
gi 21728372  303 LLFIRLRYLTGAWRLK 318
Cdd:PTZ00260 309 ILLVRSFYLLGIWKVK 324
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 64-288 3.61e-32

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 119.04  E-value: 3.61e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  64 TKQLSVVVPSYNEEKRLPVMMDEALNYLekrqkhdcTFTYEVIVVDDGSEDQTSKVALKYCQKYgsDKVRVITLVRNRGK 143
Cdd:COG0463   1 MPLVSVVIPTYNEEEYLEEALESLLAQT--------YPDFEIIVVDDGSTDGTAEILRELAAKD--PRIRVIRLERNRGK 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372 144 GGAVRMGVFSSRGEKILMADADGatkFPDVEKLEKGLSDLQPWPEqmAIACGSRAHLEKESIaqrsyFRTFLMYGFHFLV 223
Cdd:COG0463  71 GAARNAGLAAARGDYIAFLDADD---QLDPEKLEELVAALEEGPA--DLVYGSRLIREGESD-----LRRLGSRLFNLVR 140

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21728372 224 WFLCvkgIRDTQCGFKLLTREAAARTFSSlhiERWAFDVELLYIAQcLQIPIAEVAVNWTEIEGS 288
Cdd:COG0463 141 LLTN---LPDSTSGFRLFRREVLEELGFD---EGFLEDTELLRALR-HGFRIAEVPVRYRAGESK 198
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 68-245 1.04e-25

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 100.55  E-value: 1.04e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372    68 SVVVPSYNEEKRLPVMMDEALNylekrQKHDctfTYEVIVVDDGSEDQTSKVALKYCQKYgsDKVRVITLVRNRGKGGAV 147
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLN-----QTYP---NFEIIVVDDGSTDGTVEIAEEYAKKD--PRVRVIRLPENRGKAGAR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372   148 RMGVFSSRGEKILMADADGATKFPDVEKLEKGLSDLQPwpeqmAIACGSRAHLEKESIAQRSYFRTFLMYGFHFLVWFLC 227
Cdd:pfam00535  71 NAGLRAATGDYIAFLDADDEVPPDWLEKLVEALEEDGA-----DVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLL 145

                         170
                  ....*....|....*...
gi 21728372   228 VKGIRDTQCGFKLLTREA 245
Cdd:pfam00535 146 GLNLPFLIGGFALYRREA 163
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 67-182 2.86e-09

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 56.37  E-value: 2.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372    67 LSVVVPSYNEEKRLPvmmdEALNYLeKRQKHDCtftyEVIVVDDGSEDQTSKVAlkycqkyGSDKVRVITLVRNRgkggA 146
Cdd:TIGR04283   1 LSIIIPVLNEAATLP----ELLADL-QALRGDA----EVIVVDGGSTDGTVEIA-------RSLGAKVIHSPKGR----A 60

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 21728372   147 VRM--GVFSSRGEKILMADADgaTKFPD--VEKLEKGLSD 182
Cdd:TIGR04283  61 RQMnaGAALAKGDILLFLHAD--TRLPKdfLEAIRRALAK 98
EPS_HpsE NF038302
hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;
67-124 2.27e-06

hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;


Pssm-ID: 439602 [Multi-domain]  Cd Length: 307  Bit Score: 48.25  E-value: 2.27e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372   67 LSVVVPSYNEEKRLPVMMDeALnyleKRQKHDCTFTYEVIVVDDGSEDQTSKV------------ALKYC 124
Cdd:NF038302   3 FTVAIPTYNGANRLPEVLE-RL----RSQIGTESLSWEIIVVDNNSTDNTAQVvqeyqknwpspyPLRYC 67
 
Name Accession Description Interval E-value
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 69-289 1.05e-123

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 353.03  E-value: 1.05e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  69 VVVPSYNEEKRLPVMMDEALNYLEKRQKhdctFTYEVIVVDDGSEDQTSKVALKYCQKYGSDkVRVITLVRNRGKGGAVR 148
Cdd:cd04188   1 VVIPAYNEEKRLPPTLEEAVEYLEERPS----FSYEIIVVDDGSKDGTAEVARKLARKNPAL-IRVLTLPKNRGKGGAVR 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372 149 MGVFSSRGEKILMADADGATKFPDVEKLEKglsdlQPWPEQMAIACGSRAHLEKESIAQRSYFRTFLMYGFHFLVWFLCV 228
Cdd:cd04188  76 AGMLAARGDYILFADADLATPFEELEKLEE-----ALKTSGYDIAIGSRAHLASAAVVKRSWLRNLLGRGFNFLVRLLLG 150

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21728372 229 KGIRDTQCGFKLLTREAAARTFSSLHIERWAFDVELLYIAQCLQIPIAEVAVNWTEIEGSK 289
Cdd:cd04188 151 LGIKDTQCGFKLFTRDAARRLFPRLHLERWAFDVELLVLARRLGYPIEEVPVRWVEIPGSK 211
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 66-318 2.87e-119

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 346.75  E-value: 2.87e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372   66 QLSVVVPSYNEEKRLPVMMDEALNYLEKRQKHDCTFTYEVIVVDDGSEDQTSKVALKYCQKYGSDKV--RVITLVRNRGK 143
Cdd:PTZ00260  71 DLSIVIPAYNEEDRLPKMLKETIKYLESRSRKDPKFKYEIIIVNDGSKDKTLKVAKDFWRQNINPNIdiRLLSLLRNKGK 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  144 GGAVRMGVFSSRGEKILMADADGATKFPDVEKLEKGLsdLQPWPEQMAIACGSRAHLEK-ESIAQRSYFRTFLMYGFHFL 222
Cdd:PTZ00260 151 GGAVRIGMLASRGKYILMVDADGATDIDDFDKLEDIM--LKIEQNGLGIVFGSRNHLVDsDVVAKRKWYRNILMYGFHFI 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  223 VWFLCVKGIRDTQCGFKLLTREAAARTFSSLHIERWAFDVELLYIAQCLQIPIAEVAVNWTEIEGSKLVPFWSWLQMGKD 302
Cdd:PTZ00260 229 VNTICGTNLKDTQCGFKLFTRETARIIFPSLHLERWAFDIEIVMIAQKLNLPIAEVPVNWTEVEGSKLNVISASIQMARD 308

                        250
                 ....*....|....*.
gi 21728372  303 LLFIRLRYLTGAWRLK 318
Cdd:PTZ00260 309 ILLVRSFYLLGIWKVK 324
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 69-268 5.42e-59

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 187.40  E-value: 5.42e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  69 VVVPSYNEEKRLPVMMDEALNYLEKrqkhdcTFTYEVIVVDDGSEDQTSKVALKYCQKYGsdKVRVITLVRNRGKGGAVR 148
Cdd:cd04179   1 VVIPAYNEEENIPELVERLLAVLEE------GYDYEIIVVDDGSTDGTAEIARELAARVP--RVRVIRLSRNFGKGAAVR 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372 149 MGVFSSRGEKILMADADGATKFPDVEKLEKGLsdlqpWPEQMAIACGSRAHleKESIAQRSYFRTFLMYGFHFLVWFLCV 228
Cdd:cd04179  73 AGFKAARGDIVVTMDADLQHPPEDIPKLLEKL-----LEGGADVVIGSRFV--RGGGAGMPLLRRLGSRLFNFLIRLLLG 145

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 21728372 229 KGIRDTQCGFKLLTREAAARTFSSLHIERWAFDVELLYIA 268
Cdd:cd04179 146 VRISDTQSGFRLFRREVLEALLSLLESNGFEFGLELLVGA 185
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 64-288 3.61e-32

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 119.04  E-value: 3.61e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  64 TKQLSVVVPSYNEEKRLPVMMDEALNYLekrqkhdcTFTYEVIVVDDGSEDQTSKVALKYCQKYgsDKVRVITLVRNRGK 143
Cdd:COG0463   1 MPLVSVVIPTYNEEEYLEEALESLLAQT--------YPDFEIIVVDDGSTDGTAEILRELAAKD--PRIRVIRLERNRGK 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372 144 GGAVRMGVFSSRGEKILMADADGatkFPDVEKLEKGLSDLQPWPEqmAIACGSRAHLEKESIaqrsyFRTFLMYGFHFLV 223
Cdd:COG0463  71 GAARNAGLAAARGDYIAFLDADD---QLDPEKLEELVAALEEGPA--DLVYGSRLIREGESD-----LRRLGSRLFNLVR 140

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21728372 224 WFLCvkgIRDTQCGFKLLTREAAARTFSSlhiERWAFDVELLYIAQcLQIPIAEVAVNWTEIEGS 288
Cdd:COG0463 141 LLTN---LPDSTSGFRLFRREVLEELGFD---EGFLEDTELLRALR-HGFRIAEVPVRYRAGESK 198
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 68-245 1.04e-25

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 100.55  E-value: 1.04e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372    68 SVVVPSYNEEKRLPVMMDEALNylekrQKHDctfTYEVIVVDDGSEDQTSKVALKYCQKYgsDKVRVITLVRNRGKGGAV 147
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLN-----QTYP---NFEIIVVDDGSTDGTVEIAEEYAKKD--PRVRVIRLPENRGKAGAR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372   148 RMGVFSSRGEKILMADADGATKFPDVEKLEKGLSDLQPwpeqmAIACGSRAHLEKESIAQRSYFRTFLMYGFHFLVWFLC 227
Cdd:pfam00535  71 NAGLRAATGDYIAFLDADDEVPPDWLEKLVEALEEDGA-----DVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLL 145

                         170
                  ....*....|....*...
gi 21728372   228 VKGIRDTQCGFKLLTREA 245
Cdd:pfam00535 146 GLNLPFLIGGFALYRREA 163
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 69-317 1.16e-21

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 91.44  E-value: 1.16e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  69 VVVPSYNEEKRLPVMMDEALNYLEKrqkhdctFTYEVIVVDDGSEDQTSKVALKYCQKYGsdKVRVITLVRNRGKGGAVR 148
Cdd:cd06442   1 IIIPTYNERENIPELIERLDAALKG-------IDYEIIVVDDNSPDGTAEIVRELAKEYP--RVRLIVRPGKRGLGSAYI 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372 149 MGVFSSRGEKILMADADG--ATKF-PD-VEKLEKGLSDlqpwpeqmaIACGSRaHLEKESIAQRSYFRTFLMYGFHFLVW 224
Cdd:cd06442  72 EGFKAARGDVIVVMDADLshPPEYiPElLEAQLEGGAD---------LVIGSR-YVEGGGVEGWGLKRKLISRGANLLAR 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372 225 FLCVKGIRDTQCGFKLLTREAAARTFSSLHIERWAFDVELLYIAQCLQIPIAEVAVNWTE-IEG-SKLvpfwSWLQMgkd 302
Cdd:cd06442 142 LLLGRKVSDPTSGFRAYRREVLEKLIDSLVSKGYKFQLELLVRARRLGYRIVEVPITFVDrEHGeSKL----GGKEI--- 214

                       250
                ....*....|....*
gi 21728372 303 llfirLRYLTGAWRL 317
Cdd:cd06442 215 -----VEYLKGLLRL 224
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 69-246 4.66e-18

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 80.21  E-value: 4.66e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  69 VVVPSYNEEKRLPVMMDEALNYLEKRqkhdcTFTYEVIVVDDGSEDQTSKVALKYCQKYgsDKVRVITLVRNRGKGGAVR 148
Cdd:cd04187   1 IVVPVYNEEENLPELYERLKAVLESL-----GYDYEIIFVDDGSTDRTLEILRELAARD--PRVKVIRLSRNFGQQAALL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372 149 MGVFSSRGEKILMADADG---ATKFPD-VEKLEKGLSdlqpwpeqmaIACGSRAHlEKESIaqrsyFRTFLMYGFHFLVW 224
Cdd:cd04187  74 AGLDHARGDAVITMDADLqdpPELIPEmLAKWEEGYD----------VVYGVRKN-RKESW-----LKRLTSKLFYRLIN 137

                       170       180
                ....*....|....*....|..
gi 21728372 225 FLCVKGIRDTQCGFKLLTREAA 246
Cdd:cd04187 138 KLSGVDIPDNGGDFRLMDRKVV 159
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 61-165 7.48e-18

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 82.48  E-value: 7.48e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  61 DSPTKQLSVVVPSYNEEKRLPvmmdEALNYLeKRQKHDcTFTYEVIVVDDGSEDQTSKVALKYCQKYgsDKVRVITLVRN 140
Cdd:COG1215  25 PADLPRVSVIIPAYNEEAVIE----ETLRSL-LAQDYP-KEKLEVIVVDDGSTDETAEIARELAAEY--PRVRVIERPEN 96

                        90       100
                ....*....|....*....|....*
gi 21728372 141 RGKGGAVRMGVFSSRGEKILMADAD 165
Cdd:COG1215  97 GGKAAALNAGLKAARGDIVVFLDAD 121
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 69-165 9.76e-18

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 78.70  E-value: 9.76e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  69 VVVPSYNEEKRLPVMMDEALNYLEKRqkhdctftYEVIVVDDGSEDQTSKVALKYCQKYgsDKVRVITLVRNRGKGGAVR 148
Cdd:cd00761   1 VIIPAYNEEPYLERCLESLLAQTYPN--------FEVIVVDDGSTDGTLEILEEYAKKD--PRVIRVINEENQGLAAARN 70

                        90
                ....*....|....*..
gi 21728372 149 MGVFSSRGEKILMADAD 165
Cdd:cd00761  71 AGLKAARGEYILFLDAD 87
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 68-278 1.62e-14

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 72.04  E-value: 1.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372   68 SVVVPSYNEEKRLPVMMdealnYLEKRQKHDCTfTYEVIVVDDGSEDQTSKVALKYCQKYGSDKVRVITLVRNRGKGGAV 147
Cdd:PLN02726  12 SIIVPTYNERLNIALIV-----YLIFKALQDVK-DFEIIVVDDGSPDGTQDVVKQLQKVYGEDRILLRPRPGKLGLGTAY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  148 RMGVFSSRGEKILMADADGA--TKF-PDV--EKLEKGLSdlqpwpeqmaIACGSRaHLEKESIAQRSYFRTFLMYGFHFL 222
Cdd:PLN02726  86 IHGLKHASGDFVVIMDADLShhPKYlPSFikKQRETGAD----------IVTGTR-YVKGGGVHGWDLRRKLTSRGANVL 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 21728372  223 VWFLCVKGIRDTQCGFKLLTREAAARTFSSLHIERWAFDVELLYIAQCLQIPIAEV 278
Cdd:PLN02726 155 AQTLLWPGVSDLTGSFRLYKRSALEDLVSSVVSKGYVFQMEIIVRASRKGYRIEEV 210
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 69-165 2.70e-14

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 69.95  E-value: 2.70e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  69 VVVPSYNEEKRLPvmmdEALNYLeKRQKHDctfTYEVIVVDDGSEDQTSKVALKYCQKYGSDKVRVITLvRNRGKGGAVR 148
Cdd:cd06423   1 IIVPAYNEEAVIE----RTIESL-LALDYP---KLEVIVVDDGSTDDTLEILEELAALYIRRVLVVRDK-ENGGKAGALN 71

                        90
                ....*....|....*..
gi 21728372 149 MGVFSSRGEKILMADAD 165
Cdd:cd06423  72 AGLRHAKGDIVVVLDAD 88
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
63-165 8.92e-13

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 66.17  E-value: 8.92e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  63 PTKQLSVVVPSYNEEKRLpvmmDEALNYLEKRQKHDctftYEVIVVDDGSEDQTskvaLKYCQKYGSDKVRVITLVRNRG 142
Cdd:COG1216   1 MRPKVSVVIPTYNRPELL----RRCLESLLAQTYPP----FEVIVVDNGSTDGT----AELLAALAFPRVRVIRNPENLG 68

                        90       100
                ....*....|....*....|...
gi 21728372 143 KGGAVRMGVFSSRGEKILMADAD 165
Cdd:COG1216  69 FAAARNLGLRAAGGDYLLFLDDD 91
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 49-165 9.13e-12

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 64.14  E-value: 9.13e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  49 AKGQKEALPSIwdsptkqlSVVVPSYNEEKRLPVMMDE--ALNYLEKRqkhdctftYEVIVVDDGSEDQTSKVAlkycQK 126
Cdd:cd06439  21 SLPDPAYLPTV--------TIIIPAYNEEAVIEAKLENllALDYPRDR--------LEIIVVSDGSTDGTAEIA----RE 80

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 21728372 127 YGSDKVRVITLVRNRGKGGAVRMGVFSSRGEKILMADAD 165
Cdd:cd06439  81 YADKGVKLLRFPERRGKAAALNRALALATGEIVVFTDAN 119
PRK10714 PRK10714
undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional
 63-165 6.85e-11

undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional


Pssm-ID: 182669 [Multi-domain]  Cd Length: 325  Bit Score: 62.45  E-value: 6.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372   63 PTKQLSVVVPSYNEEKRLPVMMDEALNYLEKRQKhdctfTYEVIVVDDGSEDQTSKVALKYCQKYGSDKVRVItLVRNRG 142
Cdd:PRK10714   4 PIKKVSVVIPVYNEQESLPELIRRTTAACESLGK-----EYEILLIDDGSSDNSAEMLVEAAQAPDSHIVAIL-LNRNYG 77

                         90       100
                 ....*....|....*....|...
gi 21728372  143 KGGAVRMGVFSSRGEKILMADAD 165
Cdd:PRK10714  78 QHSAIMAGFSHVTGDLIITLDAD 100
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 67-182 2.86e-09

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 56.37  E-value: 2.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372    67 LSVVVPSYNEEKRLPvmmdEALNYLeKRQKHDCtftyEVIVVDDGSEDQTSKVAlkycqkyGSDKVRVITLVRNRgkggA 146
Cdd:TIGR04283   1 LSIIIPVLNEAATLP----ELLADL-QALRGDA----EVIVVDGGSTDGTVEIA-------RSLGAKVIHSPKGR----A 60

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 21728372   147 VRM--GVFSSRGEKILMADADgaTKFPD--VEKLEKGLSD 182
Cdd:TIGR04283  61 RQMnaGAALAKGDILLFLHAD--TRLPKdfLEAIRRALAK 98
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 61-165 3.47e-09

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 56.98  E-value: 3.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372   61 DSPTKQLSVVVPSYNEEKRLPVMMDEALnylekRQKHDctfTYEVIVVDDGSEDQTSKVALKYCQKYGsdKVRVITLvRN 140
Cdd:PRK10073   2 MNSTPKLSIIIPLYNAGKDFRAFMESLI-----AQTWT---ALEIIIVNDGSTDNSVEIAKHYAENYP--HVRLLHQ-AN 70

                         90       100
                 ....*....|....*....|....*
gi 21728372  141 RGKGGAVRMGVFSSRGEKILMADAD 165
Cdd:PRK10073  71 AGVSVARNTGLAVATGKYVAFPDAD 95
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 69-165 3.69e-09

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 56.14  E-value: 3.69e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  69 VVVPSYNEEKRLPVMMD--EALNYlEKRQkhdctftYEVIVVDDGSEDQTSKVaLKYCQKYGSDKVRVITLVR--NRGKG 144
Cdd:cd04192   1 VVIAARNEAENLPRLLQslSALDY-PKEK-------FEVILVDDHSTDGTVQI-LEFAAAKPNFQLKILNNSRvsISGKK 71

                        90       100
                ....*....|....*....|.
gi 21728372 145 GAVRMGVFSSRGEKILMADAD 165
Cdd:cd04192  72 NALTTAIKAAKGDWIVTTDAD 92
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 68-166 1.33e-08

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 54.55  E-value: 1.33e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  68 SVVVPSYNEEKRLPVMMDEALN--YLEKRqkhdctftYEVIVVDDGSEDQTSKVALKYCQKYGSdkvrvITLVRNRGK-- 143
Cdd:cd02525   3 SIIIPVRNEEKYIEELLESLLNqsYPKDL--------IEIIVVDGGSTDGTREIVQEYAAKDPR-----IRLIDNPKRiq 69

                        90       100
                ....*....|....*....|...
gi 21728372 144 GGAVRMGVFSSRGEKILMADADG 166
Cdd:cd02525  70 SAGLNIGIRNSRGDIIIRVDAHA 92
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 67-165 7.86e-08

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 52.37  E-value: 7.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372    67 LSVVVPSYNEEKRLPVMMDEALNYLEKRqkhdctftYEVIVVDDGSEDQTSKVALKYCQKYGSDKVRVITLVRNRGKGGA 146
Cdd:pfam13641   4 VSVVVPAFNEDSVLGRVLEAILAQPYPP--------VEVVVVVNPSDAETLDVAEEIAARFPDVRLRVIRNARLLGPTGK 75

                          90       100
                  ....*....|....*....|..
gi 21728372   147 VRM--GVFSS-RGEKILMADAD 165
Cdd:pfam13641  76 SRGlnHGFRAvKSDLVVLHDDD 97
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 67-143 1.10e-07

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 51.80  E-value: 1.10e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21728372  67 LSVVVPSYNEEKRLPvmmdEALNYLEKRQKHDCtftyEVIVVDDGSEDQTSKVAlkycQKYGsdkVRVITLVRNRGK 143
Cdd:cd02522   1 LSIIIPTLNEAENLP----RLLASLRRLNPLPL----EIIVVDGGSTDGTVAIA----RSAG---VVVISSPKGRAR 62
EPS_HpsE NF038302
hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;
67-124 2.27e-06

hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;


Pssm-ID: 439602 [Multi-domain]  Cd Length: 307  Bit Score: 48.25  E-value: 2.27e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372   67 LSVVVPSYNEEKRLPVMMDeALnyleKRQKHDCTFTYEVIVVDDGSEDQTSKV------------ALKYC 124
Cdd:NF038302   3 FTVAIPTYNGANRLPEVLE-RL----RSQIGTESLSWEIIVVDNNSTDNTAQVvqeyqknwpspyPLRYC 67
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 68-148 1.25e-05

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 45.31  E-value: 1.25e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  68 SVVVPSYNEEKrlpvmmdealnYLEK------RQKHDCTftyEVIVVDDGSEDQTSKVALKYCQKYGsdkvRVITLVRNR 141
Cdd:cd04196   1 AVLMATYNGEK-----------YLREqldsilAQTYKND---ELIISDDGSTDGTVEIIKEYIDKDP----FIIILIRNG 62


                ....*..
gi 21728372 142 GKGGAVR 148
Cdd:cd04196  63 KNLGVAR 69
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 67-165 1.08e-04

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 42.66  E-value: 1.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  67 LSVVVPSYNEEKRLPvmmdEALNYLEKrqkhdctFTYEVIVVDDGSEDQTskVALkyCQKYGsdkVRVITlVRNRGKGGA 146
Cdd:cd02511   2 LSVVIITKNEERNIE----RCLESVKW-------AVDEIIVVDSGSTDRT--VEI--AKEYG---AKVYQ-RWWDGFGAQ 62

                        90
                ....*....|....*....
gi 21728372 147 VRMGVFSSRGEKILMADAD 165
Cdd:cd02511  63 RNFALELATNDWVLSLDAD 81
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 69-183 2.20e-04

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 41.01  E-value: 2.20e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  69 VVVPSYNEEKRLPvmmdEALNYLEKRQKHDctftYEVIVVDDGSEDQTSKVALKYcqkygSDKVRVITLVRNRGKGGAVR 148
Cdd:cd04186   1 IIIVNYNSLEYLK----ACLDSLLAQTYPD----FEVIVVDNASTDGSVELLREL-----FPEVRLIRNGENLGFGAGNN 67

                        90       100       110
                ....*....|....*....|....*....|....*
gi 21728372 149 MGVFSSRGEKILMADadgatkfPDVEKLEKGLSDL 183
Cdd:cd04186  68 QGIREAKGDYVLLLN-------PDTVVEPGALLEL 95
PRK13915 PRK13915
putative glucosyl-3-phosphoglycerate synthase; Provisional
 68-165 4.12e-04

putative glucosyl-3-phosphoglycerate synthase; Provisional


Pssm-ID: 237556 [Multi-domain]  Cd Length: 306  Bit Score: 41.44  E-value: 4.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372   68 SVVVPSYNEEKRLPVMMDEALNYLEKrqkhdcTFTYEVIVVDDGSEDQTSKVAlkycQKYGSdkvRVIT-------LVRN 140
Cdd:PRK13915  34 SVVLPALNEEETVGKVVDSIRPLLME------PLVDELIVIDSGSTDATAERA----AAAGA---RVVSreeilpeLPPR 100

                         90       100
                 ....*....|....*....|....*
gi 21728372  141 RGKGGAVRMGVFSSRGEKILMADAD 165
Cdd:PRK13915 101 PGKGEALWRSLAATTGDIVVFVDAD 125
pp-GalNAc-T cd02510
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide ...
 104-142 5.27e-04

pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferases (pp-GalNAc-T) initiate the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to hydroxyl groups of Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-a-1-O-Ser/Thr). These enzymes are type II membrane proteins with a GT-A type catalytic domain and a lectin domain located on the lumen side of the Golgi apparatus. In human, there are 15 isozymes of pp-GalNAc-Ts, representing the largest of all glycosyltransferase families. Each isozyme has unique but partially redundant substrate specificity for glycosylation sites on acceptor proteins.


Pssm-ID: 133004 [Multi-domain]  Cd Length: 299  Bit Score: 41.04  E-value: 5.27e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 21728372 104 EVIVVDDGSEDQTSKVALKYCQKYGSDKVRVITLVRNRG 142
Cdd:cd02510  32 EIILVDDFSDKPELKLLLEEYYKKYLPKVKVLRLKKREG 70
Glyco_tranf_2_2 pfam10111
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 68-184 1.15e-03

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 313356 [Multi-domain]  Cd Length: 276  Bit Score: 39.95  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372    68 SVVVPSYNEEKRlPVMMDEALNyleKRQKHDCTFtyEVIVVDDGSEDQTSKVALKYCQ-------KYGSDKVRVITLVRN 140
Cdd:pfam10111   1 SVVIPVYNGEKT-HWIQERILN---QTFQYDPEF--ELIIINDGSTDKTLEEVSSIKDhnlqvyyPNAPDTTYSLAASRN 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 21728372   141 RGKGGAVrmgvfssrGEKILMADADgatKFPDVEKLEKGLSDLQ 184
Cdd:pfam10111  75 RGTSHAI--------GEYISFIDGD---CLWSPDKFEKQLKIAT 107
CESA_NdvC_like cd06435
NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; ...
 68-165 8.38e-03

NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase. Bradyrhizobium japonicum synthesizes periplasmic cyclic beta-(1,3),beta-(1,6)-D-glucans during growth under hypoosmotic conditions. Two genes (ndvB, ndvC) are involved in the beta-(1, 3), beta-(1,6)-glucan synthesis. The ndvC mutant strain resulted in synthesis of altered cyclic beta-glucans composed almost entirely of beta-(1, 3)-glycosyl linkages. The periplasmic cyclic beta-(1,3),beta-(1,6)-D-glucans function for osmoregulation. The ndvC mutation also affects the ability of the bacteria to establish a successful symbiotic interaction with host plant. Thus, the beta-glucans may function as suppressors of a host defense response.


Pssm-ID: 133057 [Multi-domain]  Cd Length: 236  Bit Score: 36.99  E-value: 8.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728372  68 SVVVPSYNEEkrlPVMMDEALNYLEKRQKHDctftYEVIVVDDGSEDQTSKVALK-YCQKYGsDKVRVITLVRNRG-KGG 145
Cdd:cd06435   1 SIHVPCYEEP---PEMVKETLDSLAALDYPN----FEVIVIDNNTKDEALWKPVEaHCAQLG-ERFRFFHVEPLPGaKAG 72

                        90       100
                ....*....|....*....|..
gi 21728372 146 AVR--MGVFSSRGEKILMADAD 165
Cdd:cd06435  73 ALNyaLERTAPDAEIIAVIDAD 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH