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Conserved domains on  [gi|13385472|ref|NP_080250|]
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large ribosomal subunit protein eL14 [Mus musculus]

Protein Classification

60S ribosomal protein L14( domain architecture ID 10149547)

60S ribosomal protein L14 is a component of the large ribosomal subunit; the ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
eL14 cd23702
Vairimorpha necatrix ribosomal protein eL14 and similar proteins; eL14 is a component of the ...
 5-123 2.77e-36

Vairimorpha necatrix ribosomal protein eL14 and similar proteins; eL14 is a component of the large subunit (LSU) of the microsporidian ribosome that reveals a prokaryotic-like rRNA core covered with eukaryotic ribosomal proteins.


:

Pssm-ID: 467915 [Multi-domain]  Cd Length: 82  Bit Score: 122.17  E-value: 2.77e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385472   5 RYVEVGRVAYISFGPHAGKLVAIVDVIDQNRALVDGPCTRVRRQAMPFKCMQLTDFILKFPhsarqkyvrkawekadint 84
Cdd:cd23702   1 RFVEVGRVVLINYGPDAGKLAVIVDIIDQNRVLVDGPKTGVKRQVVNLKRLSLTDFVVKIP------------------- 61

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 13385472  85 kwaatrwakkidarerkaKMTDFDRFKVMKAKKMRNRII 123
Cdd:cd23702  62 ------------------NLTDFDRFKVMLAKKKRRKLV 82
 
Name Accession Description Interval E-value
eL14 cd23702
Vairimorpha necatrix ribosomal protein eL14 and similar proteins; eL14 is a component of the ...
 5-123 2.77e-36

Vairimorpha necatrix ribosomal protein eL14 and similar proteins; eL14 is a component of the large subunit (LSU) of the microsporidian ribosome that reveals a prokaryotic-like rRNA core covered with eukaryotic ribosomal proteins.


Pssm-ID: 467915 [Multi-domain]  Cd Length: 82  Bit Score: 122.17  E-value: 2.77e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385472   5 RYVEVGRVAYISFGPHAGKLVAIVDVIDQNRALVDGPCTRVRRQAMPFKCMQLTDFILKFPhsarqkyvrkawekadint 84
Cdd:cd23702   1 RFVEVGRVVLINYGPDAGKLAVIVDIIDQNRVLVDGPKTGVKRQVVNLKRLSLTDFVVKIP------------------- 61

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 13385472  85 kwaatrwakkidarerkaKMTDFDRFKVMKAKKMRNRII 123
Cdd:cd23702  62 ------------------NLTDFDRFKVMLAKKKRRKLV 82
Ribosomal_L14e pfam01929
Ribosomal protein L14; This family includes the eukaryotic ribosomal protein L14.
 47-120 4.60e-34

Ribosomal protein L14; This family includes the eukaryotic ribosomal protein L14.


Pssm-ID: 460388  Cd Length: 74  Bit Score: 116.45  E-value: 4.60e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13385472    47 RQAMPFKCMQLTDFILKFPHSARQKYVRKAWEKADINTKWAATRWAKKIDARERKAKMTDFDRFKVMKAKKMRN 120
Cdd:pfam01929   1 RQVIPLKRLHLTKFVIKLPRGARTGAVKKAWEKADVDEKWAESAWAKKLAAREKRANLTDFDRFKVMVAKKQRR 74
PTZ00065 PTZ00065
60S ribosomal protein L14; Provisional
 2-128 8.73e-33

60S ribosomal protein L14; Provisional


Pssm-ID: 240252 [Multi-domain]  Cd Length: 130  Bit Score: 114.86  E-value: 8.73e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385472    2 VFRRYVEVGRVAYISFGPHAGKLVAIVDVIDQNRALVDGP-CTRVRRQAMPFKCMQLTDFILKFPHSARQKYVRKAWEKA 80
Cdd:PTZ00065   3 LFKRFVEPGRLCLIQYGPDAGKLCFIVDIVTPTRVLVDGAfITGVKRQSIPLKRLKLTDEKIKINRGARTGTLKKALKKD 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 13385472   81 DINTKWAATRWAKKIDARERKAKMTDFDRFKVMKAKKMRNRIIKTEVK 128
Cdd:PTZ00065  83 NALEEFNKTSLGKKLIIKEKRANMTDFERFKLMVAKKERRKLMKSLKK 130
 
Name Accession Description Interval E-value
eL14 cd23702
Vairimorpha necatrix ribosomal protein eL14 and similar proteins; eL14 is a component of the ...
 5-123 2.77e-36

Vairimorpha necatrix ribosomal protein eL14 and similar proteins; eL14 is a component of the large subunit (LSU) of the microsporidian ribosome that reveals a prokaryotic-like rRNA core covered with eukaryotic ribosomal proteins.


Pssm-ID: 467915 [Multi-domain]  Cd Length: 82  Bit Score: 122.17  E-value: 2.77e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385472   5 RYVEVGRVAYISFGPHAGKLVAIVDVIDQNRALVDGPCTRVRRQAMPFKCMQLTDFILKFPhsarqkyvrkawekadint 84
Cdd:cd23702   1 RFVEVGRVVLINYGPDAGKLAVIVDIIDQNRVLVDGPKTGVKRQVVNLKRLSLTDFVVKIP------------------- 61

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 13385472  85 kwaatrwakkidarerkaKMTDFDRFKVMKAKKMRNRII 123
Cdd:cd23702  62 ------------------NLTDFDRFKVMLAKKKRRKLV 82
Ribosomal_L14e pfam01929
Ribosomal protein L14; This family includes the eukaryotic ribosomal protein L14.
 47-120 4.60e-34

Ribosomal protein L14; This family includes the eukaryotic ribosomal protein L14.


Pssm-ID: 460388  Cd Length: 74  Bit Score: 116.45  E-value: 4.60e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13385472    47 RQAMPFKCMQLTDFILKFPHSARQKYVRKAWEKADINTKWAATRWAKKIDARERKAKMTDFDRFKVMKAKKMRN 120
Cdd:pfam01929   1 RQVIPLKRLHLTKFVIKLPRGARTGAVKKAWEKADVDEKWAESAWAKKLAAREKRANLTDFDRFKVMVAKKQRR 74
PTZ00065 PTZ00065
60S ribosomal protein L14; Provisional
 2-128 8.73e-33

60S ribosomal protein L14; Provisional


Pssm-ID: 240252 [Multi-domain]  Cd Length: 130  Bit Score: 114.86  E-value: 8.73e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385472    2 VFRRYVEVGRVAYISFGPHAGKLVAIVDVIDQNRALVDGP-CTRVRRQAMPFKCMQLTDFILKFPHSARQKYVRKAWEKA 80
Cdd:PTZ00065   3 LFKRFVEPGRLCLIQYGPDAGKLCFIVDIVTPTRVLVDGAfITGVKRQSIPLKRLKLTDEKIKINRGARTGTLKKALKKD 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 13385472   81 DINTKWAATRWAKKIDARERKAKMTDFDRFKVMKAKKMRNRIIKTEVK 128
Cdd:PTZ00065  83 NALEEFNKTSLGKKLIIKEKRANMTDFERFKLMVAKKERRKLMKSLKK 130
KOW_RPL14 cd06088
KOW motif of Ribosomal Protein L14; RPL14 is a component of the large ribosomal subunit in ...
 7-81 3.99e-27

KOW motif of Ribosomal Protein L14; RPL14 is a component of the large ribosomal subunit in both archaea and eukaryotes with KOW motif at its N terminal. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. Auto-antibodies to RPL14 in humans have been associated with systemic lupus erythematosus . Although RPL14 is well conserved, it is not found in all archaea, and therefore it is presumably not essential.


Pssm-ID: 240512  Cd Length: 76  Bit Score: 98.70  E-value: 3.99e-27
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13385472   7 VEVGRVAYISFGPHAGKLVAIVDVIDQNRALVDGPCTR-VRRQAMPFKCMQLTDFILKFPHSARQKYVRKAWEKAD 81
Cdd:cd06088   1 VEIGRVVLSKAGRDKGKLYVIVDIIDENVVLVDGPLRTgVKPKKKNLKHLQLTDFVIDIPRGARTKGVKKANEKLR 76
PRK04333 PRK04333
50S ribosomal protein L14e; Validated
 7-82 5.69e-09

50S ribosomal protein L14e; Validated


Pssm-ID: 235283  Cd Length: 84  Bit Score: 51.22  E-value: 5.69e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13385472    7 VEVGRVAYISFGPHAGKLVAIVDVIDQNRALVDGP-CTRVRRQAMPFKCMQLTDFILKFPHSARQKYVRKAWEKADI 82
Cdd:PRK04333   4 IEVGRVCVKTAGREAGRKCVIVDIIDKNFVLVTGPsLTGVKRRRCNIKHLEPTDKKVDIEKGASDEEVKKALEAAGL 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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