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Conserved domains on  [gi|21313344|ref|NP_080392|]
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Bardet-Biedl syndrome 2 protein homolog [Mus musculus]

Protein Classification

BBS2_N and BBS2_C domain-containing protein( domain architecture ID 11236587)

protein containing domains BBS2_N, BBS2_Mid, and BBS2_C

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BBS2_C pfam14782
Ciliary BBSome complex subunit 2, C-terminal; The BBSome (so-named after the association with ...
 276-715 0e+00

Ciliary BBSome complex subunit 2, C-terminal; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


:

Pssm-ID: 464315  Cd Length: 430  Bit Score: 727.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344   276 TGEVIFKDNFSSAVAGVVEGDYRMDGHVQLICCSVDGEIRGYLPGTAEMKGNLLDTSVEQDLIRELSQKKQNLLLELRNY 355
Cdd:pfam14782   1 TGEVIFKDNLSSPIAGLVVADYRMDGKNQLICCSVDGEVRGYLPTGQEMKGALVDTSVEQELIRELLQKKQNLLLELKNY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344   356 EESTKAelssplNEADGQKGIIPANTRLHTALSVNmgndLQDAHAELGISTSNDTIIRAVLIFAEGIFVGESHVVHPsIH 435
Cdd:pfam14782  81 EENLKR------KKSGETDGTIPANTKLQTSLSVN----LETGHVELVVSTNNDTIIRAVIIFAEGIFEGESHVVHP-NQ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344   436 NLSSSLRVPITPPKDVPVDLHLKTFVGYRSSTQFHVFELTRQLPRFTMYALTSPDAASEPVSYVNFSVAERTQRMVTWLN 515
Cdd:pfam14782 150 NPSSTLRIPLRPPKDVPVDLHIKVFVGSPGSSQFHVFELTRQLPKFSMYLLVKNPEPPEPSSYVTFRINERVQRVVLWLN 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344   516 QNFLLPEDSNVQ-NSPFHVCFTSLRNGGQLYIKMKQSGEITVNTDDIDLAGDIIQSIASFFAIEDLQVEADFPVYFEELR 594
Cdd:pfam14782 230 QNFLLPEEIEDEdESNLELKFISLRDGSPLVISVNASGKVTIRTDDMELAGDIIQSLASFLNITDLESTADFPDEMEELR 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344   595 KVLVKVDEYHSVHQKLSADMADNSNLIRSLLVRAEDARLMRDMKTMKSRYMELYDLNKDLLNGYKIRCNNHTELLGNLKA 674
Cdd:pfam14782 310 EILEKVDELNSVRQKLTAEMADSSNLVKSLIVRAEDARLLGDMKNMRKYYSELMDLNRDLIGEYQKRSNNHNELLSALKE 389

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 21313344   675 VNQAIQRAGRLRVGKPKNQVISACRDAIRSNNINTLFRIMR 715
Cdd:pfam14782 390 VNQMIQKASRLRVGKAKTQVIAACRNAIKNNNINALFKIIR 430
BBS2_N pfam14781
Ciliary BBSome complex subunit 2, N-terminal; The BBSome (so-named after the association with ...
 20-126 8.88e-61

Ciliary BBSome complex subunit 2, N-terminal; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


:

Pssm-ID: 464314  Cd Length: 107  Bit Score: 199.01  E-value: 8.88e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344    20 AIGRYDGTHPCLAAATQAGKVFIHNPHTRSQHFSASRVFQSPLESDVSLLNINQTVSCLGSGVLNPELGYDTLLVGTQTS 99
Cdd:pfam14781   1 TVGKYDGVHPCLTCATTAGKVFIHNPHSRSQKLKSGRLSQSAQDSDVSLLNINQAVTALTAGRLDPDSGRDILLVGTQTN 80

                          90       100
                  ....*....|....*....|....*..
gi 21313344   100 LLAYDIYNNSDLFYREVSDGANAIVLG 126
Cdd:pfam14781  81 LLAYDVENNSDLFYKEVPDGVNAIVFG 107
BBS2_Mid pfam14783
Ciliary BBSome complex subunit 2, middle region; The BBSome (so-named after the association ...
 165-272 1.27e-60

Ciliary BBSome complex subunit 2, middle region; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


:

Pssm-ID: 405473 [Multi-domain]  Cd Length: 108  Bit Score: 198.64  E-value: 1.27e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344   165 SLALCDFDGDGKTELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTARYWRIKSKNHA 244
Cdd:pfam14783   1 ALALADFDGDGENELVVGSDDFDIRVFKGDEIVFEFTETEKVTSLATLSGSRFAYALENGTVGVYDKKQRLWRIKSKNQI 80

                          90       100
                  ....*....|....*....|....*...
gi 21313344   245 MSIHAFDINSDGVCELITGWSNGKVDAR 272
Cdd:pfam14783  81 TALAAYDINGDGVKELIVGWSNGKVDAR 108
 
Name Accession Description Interval E-value
BBS2_C pfam14782
Ciliary BBSome complex subunit 2, C-terminal; The BBSome (so-named after the association with ...
 276-715 0e+00

Ciliary BBSome complex subunit 2, C-terminal; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


Pssm-ID: 464315  Cd Length: 430  Bit Score: 727.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344   276 TGEVIFKDNFSSAVAGVVEGDYRMDGHVQLICCSVDGEIRGYLPGTAEMKGNLLDTSVEQDLIRELSQKKQNLLLELRNY 355
Cdd:pfam14782   1 TGEVIFKDNLSSPIAGLVVADYRMDGKNQLICCSVDGEVRGYLPTGQEMKGALVDTSVEQELIRELLQKKQNLLLELKNY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344   356 EESTKAelssplNEADGQKGIIPANTRLHTALSVNmgndLQDAHAELGISTSNDTIIRAVLIFAEGIFVGESHVVHPsIH 435
Cdd:pfam14782  81 EENLKR------KKSGETDGTIPANTKLQTSLSVN----LETGHVELVVSTNNDTIIRAVIIFAEGIFEGESHVVHP-NQ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344   436 NLSSSLRVPITPPKDVPVDLHLKTFVGYRSSTQFHVFELTRQLPRFTMYALTSPDAASEPVSYVNFSVAERTQRMVTWLN 515
Cdd:pfam14782 150 NPSSTLRIPLRPPKDVPVDLHIKVFVGSPGSSQFHVFELTRQLPKFSMYLLVKNPEPPEPSSYVTFRINERVQRVVLWLN 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344   516 QNFLLPEDSNVQ-NSPFHVCFTSLRNGGQLYIKMKQSGEITVNTDDIDLAGDIIQSIASFFAIEDLQVEADFPVYFEELR 594
Cdd:pfam14782 230 QNFLLPEEIEDEdESNLELKFISLRDGSPLVISVNASGKVTIRTDDMELAGDIIQSLASFLNITDLESTADFPDEMEELR 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344   595 KVLVKVDEYHSVHQKLSADMADNSNLIRSLLVRAEDARLMRDMKTMKSRYMELYDLNKDLLNGYKIRCNNHTELLGNLKA 674
Cdd:pfam14782 310 EILEKVDELNSVRQKLTAEMADSSNLVKSLIVRAEDARLLGDMKNMRKYYSELMDLNRDLIGEYQKRSNNHNELLSALKE 389

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 21313344   675 VNQAIQRAGRLRVGKPKNQVISACRDAIRSNNINTLFRIMR 715
Cdd:pfam14782 390 VNQMIQKASRLRVGKAKTQVIAACRNAIKNNNINALFKIIR 430
BBS2_N pfam14781
Ciliary BBSome complex subunit 2, N-terminal; The BBSome (so-named after the association with ...
 20-126 8.88e-61

Ciliary BBSome complex subunit 2, N-terminal; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


Pssm-ID: 464314  Cd Length: 107  Bit Score: 199.01  E-value: 8.88e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344    20 AIGRYDGTHPCLAAATQAGKVFIHNPHTRSQHFSASRVFQSPLESDVSLLNINQTVSCLGSGVLNPELGYDTLLVGTQTS 99
Cdd:pfam14781   1 TVGKYDGVHPCLTCATTAGKVFIHNPHSRSQKLKSGRLSQSAQDSDVSLLNINQAVTALTAGRLDPDSGRDILLVGTQTN 80

                          90       100
                  ....*....|....*....|....*..
gi 21313344   100 LLAYDIYNNSDLFYREVSDGANAIVLG 126
Cdd:pfam14781  81 LLAYDVENNSDLFYKEVPDGVNAIVFG 107
BBS2_Mid pfam14783
Ciliary BBSome complex subunit 2, middle region; The BBSome (so-named after the association ...
 165-272 1.27e-60

Ciliary BBSome complex subunit 2, middle region; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


Pssm-ID: 405473 [Multi-domain]  Cd Length: 108  Bit Score: 198.64  E-value: 1.27e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344   165 SLALCDFDGDGKTELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTARYWRIKSKNHA 244
Cdd:pfam14783   1 ALALADFDGDGENELVVGSDDFDIRVFKGDEIVFEFTETEKVTSLATLSGSRFAYALENGTVGVYDKKQRLWRIKSKNQI 80

                          90       100
                  ....*....|....*....|....*...
gi 21313344   245 MSIHAFDINSDGVCELITGWSNGKVDAR 272
Cdd:pfam14783  81 TALAAYDINGDGVKELIVGWSNGKVDAR 108
 
Name Accession Description Interval E-value
BBS2_C pfam14782
Ciliary BBSome complex subunit 2, C-terminal; The BBSome (so-named after the association with ...
 276-715 0e+00

Ciliary BBSome complex subunit 2, C-terminal; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


Pssm-ID: 464315  Cd Length: 430  Bit Score: 727.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344   276 TGEVIFKDNFSSAVAGVVEGDYRMDGHVQLICCSVDGEIRGYLPGTAEMKGNLLDTSVEQDLIRELSQKKQNLLLELRNY 355
Cdd:pfam14782   1 TGEVIFKDNLSSPIAGLVVADYRMDGKNQLICCSVDGEVRGYLPTGQEMKGALVDTSVEQELIRELLQKKQNLLLELKNY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344   356 EESTKAelssplNEADGQKGIIPANTRLHTALSVNmgndLQDAHAELGISTSNDTIIRAVLIFAEGIFVGESHVVHPsIH 435
Cdd:pfam14782  81 EENLKR------KKSGETDGTIPANTKLQTSLSVN----LETGHVELVVSTNNDTIIRAVIIFAEGIFEGESHVVHP-NQ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344   436 NLSSSLRVPITPPKDVPVDLHLKTFVGYRSSTQFHVFELTRQLPRFTMYALTSPDAASEPVSYVNFSVAERTQRMVTWLN 515
Cdd:pfam14782 150 NPSSTLRIPLRPPKDVPVDLHIKVFVGSPGSSQFHVFELTRQLPKFSMYLLVKNPEPPEPSSYVTFRINERVQRVVLWLN 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344   516 QNFLLPEDSNVQ-NSPFHVCFTSLRNGGQLYIKMKQSGEITVNTDDIDLAGDIIQSIASFFAIEDLQVEADFPVYFEELR 594
Cdd:pfam14782 230 QNFLLPEEIEDEdESNLELKFISLRDGSPLVISVNASGKVTIRTDDMELAGDIIQSLASFLNITDLESTADFPDEMEELR 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344   595 KVLVKVDEYHSVHQKLSADMADNSNLIRSLLVRAEDARLMRDMKTMKSRYMELYDLNKDLLNGYKIRCNNHTELLGNLKA 674
Cdd:pfam14782 310 EILEKVDELNSVRQKLTAEMADSSNLVKSLIVRAEDARLLGDMKNMRKYYSELMDLNRDLIGEYQKRSNNHNELLSALKE 389

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 21313344   675 VNQAIQRAGRLRVGKPKNQVISACRDAIRSNNINTLFRIMR 715
Cdd:pfam14782 390 VNQMIQKASRLRVGKAKTQVIAACRNAIKNNNINALFKIIR 430
BBS2_N pfam14781
Ciliary BBSome complex subunit 2, N-terminal; The BBSome (so-named after the association with ...
 20-126 8.88e-61

Ciliary BBSome complex subunit 2, N-terminal; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


Pssm-ID: 464314  Cd Length: 107  Bit Score: 199.01  E-value: 8.88e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344    20 AIGRYDGTHPCLAAATQAGKVFIHNPHTRSQHFSASRVFQSPLESDVSLLNINQTVSCLGSGVLNPELGYDTLLVGTQTS 99
Cdd:pfam14781   1 TVGKYDGVHPCLTCATTAGKVFIHNPHSRSQKLKSGRLSQSAQDSDVSLLNINQAVTALTAGRLDPDSGRDILLVGTQTN 80

                          90       100
                  ....*....|....*....|....*..
gi 21313344   100 LLAYDIYNNSDLFYREVSDGANAIVLG 126
Cdd:pfam14781  81 LLAYDVENNSDLFYKEVPDGVNAIVFG 107
BBS2_Mid pfam14783
Ciliary BBSome complex subunit 2, middle region; The BBSome (so-named after the association ...
 165-272 1.27e-60

Ciliary BBSome complex subunit 2, middle region; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


Pssm-ID: 405473 [Multi-domain]  Cd Length: 108  Bit Score: 198.64  E-value: 1.27e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313344   165 SLALCDFDGDGKTELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTARYWRIKSKNHA 244
Cdd:pfam14783   1 ALALADFDGDGENELVVGSDDFDIRVFKGDEIVFEFTETEKVTSLATLSGSRFAYALENGTVGVYDKKQRLWRIKSKNQI 80

                          90       100
                  ....*....|....*....|....*...
gi 21313344   245 MSIHAFDINSDGVCELITGWSNGKVDAR 272
Cdd:pfam14783  81 TALAAYDINGDGVKELIVGWSNGKVDAR 108
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 165-183 8.17e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 34.41  E-value: 8.17e-03
                          10
                  ....*....|....*....
gi 21313344   165 SLALCDFDGDGKTELLVGS 183
Cdd:pfam01839   4 SVAVGDLNGDGYADLAVGA 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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