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Conserved domains on  [gi|255683353|ref|NP_080590|]
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dynein axonemal assembly factor 4 isoform 1 [Mus musculus]

Protein Classification

p23_DYX1C1_like and 3a0801s09 domain-containing protein( domain architecture ID 12950641)

protein containing domains p23_DYX1C1_like, PTZ00121, and 3a0801s09

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
p23_DYX1C1_like cd06469
p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) ...
 10-87 1.90e-36

p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) protein, DYX1C1. The human gene encoding this protein is a positional candidate gene for developmental dyslexia (DD), it is located on 15q21.3 by the DYX1 DD susceptibility locus (15q15-21). Independent association studies have reported conflicting results. However, association of short-term memory, which plays a role in DD, with a variant within the DYX1C1 gene has been reported. Most proteins belonging to this group contain a C-terminal tetratricopeptide repeat (TPR) protein binding region.


:

Pssm-ID: 107226  Cd Length: 78  Bit Score: 128.16  E-value: 1.90e-36
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255683353  10 WQQTPATIFLSLPLRGVCVRDADVFCGESYLKVNFPPFLFELFLYAPIDDGKSKAKIGNDTILFTLYKKEPVLWDSLS 87
Cdd:cd06469    1 WSQTDEDVKISVPLKGVKTSKVDIFCSDLYLKVNFPPYLFELDLAAPIDDEKSSAKIGNGVLVFTLVKKEPGIWEALC 78
3a0801s09 super family cl36792
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 250-394 3.19e-12

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


The actual alignment was detected with superfamily member TIGR00990:

Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 68.09  E-value: 3.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353  250 RESQVAEEEEWLHKQAEARRAMS----TDLPEF-----FDLKEEERN--PDWLKDKGNKLFATENYLAAVDAYNLAIRLN 318
Cdd:TIGR00990  78 KQAEKETEGKTEEKKSTAPKNAPvepaDELPEIdessvANLSEEERKkyAAKLKEKGNKAYRNKDFNKAIKLYSKAIECK 157

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 255683353  319 cKIPLLYLNRAACHLKLKNLHKAIEDSSKALELltppvadnANARMKAHVRRGTAFCQLELYVEGLQDYEAALKID 394
Cdd:TIGR00990 158 -PDPVYYSNRAACHNALGDWEKVVEDTTAALEL--------DPDYSKALNRRANAYDGLGKYADALLDLTASCIID 224
PTZ00121 super family cl31754
MAEBL; Provisional
 106-270 6.48e-04

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 6.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353  106 QAQEKAKEATEAKAVAKREDQRYALGEMMKIEEEERKKIEDMKENERKKATSELEAWKECQKKADGQKRVQRKEKPLEGK 185
Cdd:PTZ00121 1461 EAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAK 1540

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353  186 QAEETKALKPRglpRKAPPTRLPTRGRNWENifPEKLKEDRVPAPRSAGSIQISFTPRVfptalRESQVAEEEEWLHKQA 265
Cdd:PTZ00121 1541 KAEEKKKADEL---KKAEELKKAEEKKKAEE--AKKAEEDKNMALRKAEEAKKAEEARI-----EEVMKLYEEEKKMKAE 1610


                  ....*
gi 255683353  266 EARRA 270
Cdd:PTZ00121 1611 EAKKA 1615
 
Name Accession Description Interval E-value
p23_DYX1C1_like cd06469
p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) ...
 10-87 1.90e-36

p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) protein, DYX1C1. The human gene encoding this protein is a positional candidate gene for developmental dyslexia (DD), it is located on 15q21.3 by the DYX1 DD susceptibility locus (15q15-21). Independent association studies have reported conflicting results. However, association of short-term memory, which plays a role in DD, with a variant within the DYX1C1 gene has been reported. Most proteins belonging to this group contain a C-terminal tetratricopeptide repeat (TPR) protein binding region.


Pssm-ID: 107226  Cd Length: 78  Bit Score: 128.16  E-value: 1.90e-36
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255683353  10 WQQTPATIFLSLPLRGVCVRDADVFCGESYLKVNFPPFLFELFLYAPIDDGKSKAKIGNDTILFTLYKKEPVLWDSLS 87
Cdd:cd06469    1 WSQTDEDVKISVPLKGVKTSKVDIFCSDLYLKVNFPPYLFELDLAAPIDDEKSSAKIGNGVLVFTLVKKEPGIWEALC 78
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 250-394 3.19e-12

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 68.09  E-value: 3.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353  250 RESQVAEEEEWLHKQAEARRAMS----TDLPEF-----FDLKEEERN--PDWLKDKGNKLFATENYLAAVDAYNLAIRLN 318
Cdd:TIGR00990  78 KQAEKETEGKTEEKKSTAPKNAPvepaDELPEIdessvANLSEEERKkyAAKLKEKGNKAYRNKDFNKAIKLYSKAIECK 157

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 255683353  319 cKIPLLYLNRAACHLKLKNLHKAIEDSSKALELltppvadnANARMKAHVRRGTAFCQLELYVEGLQDYEAALKID 394
Cdd:TIGR00990 158 -PDPVYYSNRAACHNALGDWEKVVEDTTAALEL--------DPDYSKALNRRANAYDGLGKYADALLDLTASCIID 224
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
295-395 1.45e-10

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 60.70  E-value: 1.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353 295 GNKLFATENYLAAVDAYNLAIRLNCKIPLLYLNRAACHLKLKNLHKAIEDSSKALELltppvaDNANARmkAHVRRGTAF 374
Cdd:COG4785   80 GVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALEL------DPDYAY--AYLNRGIAL 151

                         90       100
                 ....*....|....*....|.
gi 255683353 375 CQLELYVEGLQDYEAALKIDP 395
Cdd:COG4785  152 YYLGRYELAIADLEKALELDP 172
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 291-393 1.62e-10

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 62.11  E-value: 1.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353 291 LKDKGNKLFATENYLAAVDAYNLAIRLNCKIPLLYLNRAACHLKLKNLHKAIEDSSKALElLTPPVAdnanarmKAHVRR 370
Cdd:PLN03088   5 LEDKAKEAFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIE-LDPSLA-------KAYLRK 76

                         90       100
                 ....*....|....*....|...
gi 255683353 371 GTAFCQLELYveglQDYEAALKI 393
Cdd:PLN03088  77 GTACMKLEEY----QTAKAALEK 95
CS pfam04969
CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans ...
 7-77 2.20e-07

CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies. Two CS domains are found at the N-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2.


Pssm-ID: 461503  Cd Length: 76  Bit Score: 48.02  E-value: 2.20e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 255683353    7 EFSWQQTPATIFLSLPLRGVCVRDADVFC--GESYLKVNFP--PFLFELFLYAPIDDGKSKAKIGNDTILFTLYK 77
Cdd:pfam04969   2 RYDWYQTLDEVTITIPVKGAGIKKKDVKVniKPRSLKVKIKggYELIDGELFHPIDPEESSWTIEGKKVEITLKK 76
PTZ00121 PTZ00121
MAEBL; Provisional
 106-270 6.48e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 6.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353  106 QAQEKAKEATEAKAVAKREDQRYALGEMMKIEEEERKKIEDMKENERKKATSELEAWKECQKKADGQKRVQRKEKPLEGK 185
Cdd:PTZ00121 1461 EAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAK 1540

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353  186 QAEETKALKPRglpRKAPPTRLPTRGRNWENifPEKLKEDRVPAPRSAGSIQISFTPRVfptalRESQVAEEEEWLHKQA 265
Cdd:PTZ00121 1541 KAEEKKKADEL---KKAEELKKAEEKKKAEE--AKKAEEDKNMALRKAEEAKKAEEARI-----EEVMKLYEEEKKMKAE 1610


                  ....*
gi 255683353  266 EARRA 270
Cdd:PTZ00121 1611 EAKKA 1615
TPR_1 pfam00515
Tetratricopeptide repeat;
322-351 3.78e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 34.70  E-value: 3.78e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 255683353  322 PLLYLNRAACHLKLKNLHKAIEDSSKALEL 351
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALEL 30
 
Name Accession Description Interval E-value
p23_DYX1C1_like cd06469
p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) ...
 10-87 1.90e-36

p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) protein, DYX1C1. The human gene encoding this protein is a positional candidate gene for developmental dyslexia (DD), it is located on 15q21.3 by the DYX1 DD susceptibility locus (15q15-21). Independent association studies have reported conflicting results. However, association of short-term memory, which plays a role in DD, with a variant within the DYX1C1 gene has been reported. Most proteins belonging to this group contain a C-terminal tetratricopeptide repeat (TPR) protein binding region.


Pssm-ID: 107226  Cd Length: 78  Bit Score: 128.16  E-value: 1.90e-36
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255683353  10 WQQTPATIFLSLPLRGVCVRDADVFCGESYLKVNFPPFLFELFLYAPIDDGKSKAKIGNDTILFTLYKKEPVLWDSLS 87
Cdd:cd06469    1 WSQTDEDVKISVPLKGVKTSKVDIFCSDLYLKVNFPPYLFELDLAAPIDDEKSSAKIGNGVLVFTLVKKEPGIWEALC 78
p23_like cd06463
Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) ...
 10-86 3.60e-15

Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis. Both p23 and Sba1p can regulate telomerase activity. This group includes domains similar to the C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1). Sgt1 interacts with multiple protein complexes and has the features of a co-chaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has been shown to bind Hsp90 through its CS domain. Saccharomyces cerevisiae (Sc) Sgt1 is a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Sgt1 is required for pathogen resistance in plants. This group also includes the p23_like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). hB-ind1 plays a role in the signaling pathway mediated by the small GTPase Rac1, NUDC is needed for nuclear movement, Melusin interacts with two splice variants of beta1 integrin, and NCB5OR plays a part in maintaining viable pancreatic beta cells.


Pssm-ID: 107220  Cd Length: 84  Bit Score: 70.39  E-value: 3.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353  10 WQQTPATIFLSLPLRGVCVRDADVFCGESYLKVNF-----PPFLFELFLYAPIDDGKSKAKIGNDTILFTLYKKEP-VLW 83
Cdd:cd06463    1 WYQTLDEVTITIPLKDVTKKDVKVEFTPKSLTVSVkggggKEYLLEGELFGPIDPEESKWTVEDRKIEITLKKKEPgEWW 80


                 ...
gi 255683353  84 DSL 86
Cdd:cd06463   81 PRL 83
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 250-394 3.19e-12

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 68.09  E-value: 3.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353  250 RESQVAEEEEWLHKQAEARRAMS----TDLPEF-----FDLKEEERN--PDWLKDKGNKLFATENYLAAVDAYNLAIRLN 318
Cdd:TIGR00990  78 KQAEKETEGKTEEKKSTAPKNAPvepaDELPEIdessvANLSEEERKkyAAKLKEKGNKAYRNKDFNKAIKLYSKAIECK 157

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 255683353  319 cKIPLLYLNRAACHLKLKNLHKAIEDSSKALELltppvadnANARMKAHVRRGTAFCQLELYVEGLQDYEAALKID 394
Cdd:TIGR00990 158 -PDPVYYSNRAACHNALGDWEKVVEDTTAALEL--------DPDYSKALNRRANAYDGLGKYADALLDLTASCIID 224
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
295-395 1.45e-10

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 60.70  E-value: 1.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353 295 GNKLFATENYLAAVDAYNLAIRLNCKIPLLYLNRAACHLKLKNLHKAIEDSSKALELltppvaDNANARmkAHVRRGTAF 374
Cdd:COG4785   80 GVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALEL------DPDYAY--AYLNRGIAL 151

                         90       100
                 ....*....|....*....|.
gi 255683353 375 CQLELYVEGLQDYEAALKIDP 395
Cdd:COG4785  152 YYLGRYELAIADLEKALELDP 172
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 291-393 1.62e-10

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 62.11  E-value: 1.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353 291 LKDKGNKLFATENYLAAVDAYNLAIRLNCKIPLLYLNRAACHLKLKNLHKAIEDSSKALElLTPPVAdnanarmKAHVRR 370
Cdd:PLN03088   5 LEDKAKEAFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIE-LDPSLA-------KAYLRK 76

                         90       100
                 ....*....|....*....|...
gi 255683353 371 GTAFCQLELYveglQDYEAALKI 393
Cdd:PLN03088  77 GTACMKLEEY----QTAKAALEK 95
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
285-402 8.82e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.86  E-value: 8.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353 285 ERNPDW---LKDKGNKLFATENYLAAVDAYNLAIRLNCKIPLLYLNRAACHLKLKNLHKAIEDSSKALELltppvaDNAN 361
Cdd:COG0457   36 ELDPDDaeaLYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALEL------DPDD 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 255683353 362 ARmkAHVRRGTAFCQLELYVEGLQDYEAALKIDPANTVVQN 402
Cdd:COG0457  110 AE--ALYNLGLALLELGRYDEAIEAYERALELDPDDADALY 148
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
281-397 9.95e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.86  E-value: 9.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353 281 LKEEERNPDWLKDKGNKLFATENYLAAVDAYNLAIRLNCKIPLLYLNRAACHLKLKNLHKAIEDSSKALELltppvaDNA 360
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALEL------DPD 74

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 255683353 361 NARmkAHVRRGTAFCQLELYVEGLQDYEAALKIDPAN 397
Cdd:COG0457   75 DAE--ALNNLGLALQALGRYEEALEDYDKALELDPDD 109
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 245-397 6.45e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.08  E-value: 6.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353 245 FPTALRESQVAEEEEWLHKQAEARRAMstdlpEFFD--LKEEERNPDWLKDKGNKLFATENYLAAVDAYNLAIRLNCKIP 322
Cdd:COG3914   72 AALLLLAALLELAALLLQALGRYEEAL-----ALYRraLALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFA 146

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 255683353 323 LLYLNRAACHLKLKNLHKAIEDSSKALELLtppvADNANarmkAHVRRGTAFCQLELYVEGLQDYEAALKIDPAN 397
Cdd:COG3914  147 EAYLNLGEALRRLGRLEEAIAALRRALELD----PDNAE----ALNNLGNALQDLGRLEEAIAAYRRALELDPDN 213
p23_CS_SGT1_like cd06466
p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 ...
 10-86 8.02e-09

p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has been shown to bind Hsp90 through its CS domain. Saccharomyces cerevisiae (Sc) Sgt1 is a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Sgt1 is required for pathogen resistance in plants. ScSgt1 is needed for the G1/S and G2/M cell-cycle transitions, and for assembly of the core kinetochore complex (CBF3) via activation of Ctf13, the F-box protein. Binding of Hsp82 (a yeast Hsp90 homologue) to ScSgt1, promotes the binding of Sgt1 to Skp1 and of Skp1 to Ctf13. Some proteins in this group have an SGT1-specific (SGS) domain at the extreme C-terminus. The ScSgt1-SGS domain binds adenylate cyclase. The hSgt1-SGS domain interacts with some S100 family proteins, and studies suggest that the interaction of hSgt1 with Hsp90 and Hsp70 may be regulated by S100A6 in a Ca2+ dependent fashion. This group also includes the p23_like domains of Melusin and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). Melusin is a vertebrate protein which interacts with two splice variants of beta1 integrin, and NCB5OR plays a part in maintaining viable pancreatic beta cells.


Pssm-ID: 107223  Cd Length: 84  Bit Score: 52.20  E-value: 8.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353  10 WQQTPATIFLSLPLRGVCVRDADVFCGESYLKVNFP-----PFLFELFLYAPIDDGKSKAKIGNDTILFTLYKKEPVLWD 84
Cdd:cd06466    2 WYQTDTSVTVTIYAKNVDKEDVKVEFNEQSLSVSIIlpggsEYQLELDLFGPIDPEQSKVSVLPTKVEITLKKAEPGSWP 81


                 ..
gi 255683353  85 SL 86
Cdd:cd06466   82 SL 83
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 248-402 1.39e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 56.93  E-value: 1.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353 248 ALRESQVAEEEEWLHKQAEARRAMSTDLPEFFDLKEEERNPD---WLKDKGNKLFATENYLAAVDAYNLAIRLNCKIPLL 324
Cdd:COG3914   35 AALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLlaaLLELAALLLQALGRYEEALALYRRALALNPDNAEA 114

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255683353 325 YLNRAACHLKLKNLHKAIEDSSKALELltppVADNANarmkAHVRRGTAFCQLELYVEGLQDYEAALKIDPANTVVQN 402
Cdd:COG3914  115 LFNLGNLLLALGRLEEALAALRRALAL----NPDFAE----AYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALN 184
CS pfam04969
CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans ...
 7-77 2.20e-07

CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies. Two CS domains are found at the N-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2.


Pssm-ID: 461503  Cd Length: 76  Bit Score: 48.02  E-value: 2.20e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 255683353    7 EFSWQQTPATIFLSLPLRGVCVRDADVFC--GESYLKVNFP--PFLFELFLYAPIDDGKSKAKIGNDTILFTLYK 77
Cdd:pfam04969   2 RYDWYQTLDEVTITIPVKGAGIKKKDVKVniKPRSLKVKIKggYELIDGELFHPIDPEESSWTIEGKKVEITLKK 76
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
281-396 7.04e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.01  E-value: 7.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353 281 LKEEERNPDWLKDKGNKLFATENYLAAVDAYNLAIRLNCKIPLLYLNRAACHLKLKNLHKAIEDSSKALELltppvaDNA 360
Cdd:COG0457   69 LELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALEL------DPD 142

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 255683353 361 NARmkAHVRRGTAFCQLELYVEGLQDYEAALKIDPA 396
Cdd:COG0457  143 DAD--ALYNLGIALEKLGRYEEALELLEKLEAAALA 176
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 281-412 2.68e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.54  E-value: 2.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353 281 LKEEERNPDWLKDKGNKLFATENYLAAVDAYNLAIRLNCKIPLLYLNRAACHLKLKNLHKAIEDSSKALELltppvaDNA 360
Cdd:COG4235   10 LAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL------DPD 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 255683353 361 NARmkAHVRRGTAFCQLELYVEGLQDYEAALKIDPANTvvqnDAEKIRNIIQ 412
Cdd:COG4235   84 NPE--ALYLLGLAAFQQGDYAEAIAAWQKLLALLPADA----PARLLEASIA 129
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
298-397 4.65e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 47.60  E-value: 4.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353 298 LFATENYLAAVDAYNLAIR---LNCKIPLLYLNRAACHLKLKNLHKAIEDSSKALELltppvaDNANARmkAHVRRGTAF 374
Cdd:COG4785   46 LALAAAALAAAALAAERIDralALPDLAQLYYERGVAYDSLGDYDLAIADFDQALEL------DPDLAE--AYNNRGLAY 117

                         90       100
                 ....*....|....*....|...
gi 255683353 375 CQLELYVEGLQDYEAALKIDPAN 397
Cdd:COG4785  118 LLLGDYDAALEDFDRALELDPDY 140
ACD_sHsps_p23-like cd00298
This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small ...
 10-77 7.30e-06

This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is this ACD. sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps. p23 is a cochaperone of the Hsp90 chaperoning pathway. It binds Hsp90 and participates in the folding of a number of Hsp90 clients including the progesterone receptor. p23 also has a passive chaperoning activity. p23 in addition may act as the cytosolic prostaglandin E2 synthase. Included in this family is the p23-like C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1) and the p23-like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR).


Pssm-ID: 107219  Cd Length: 80  Bit Score: 43.73  E-value: 7.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353  10 WQQTPATIFLSLPLRGVCVRDADVFCGESYLKV------------NFPPFLFELFLYAPIDDGKSKAKIGNDTILFTLYK 77
Cdd:cd00298    1 WYQTDDEVVVTVDLPGVKKEDIKVEVEDNVLTIsgkreeeeererSYGEFERSFELPEDVDPEKSKASLENGVLEITLPK 80
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 281-397 2.59e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.64  E-value: 2.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353 281 LKEEERNPDWLKDKGNKLFATENYLAAVDAYNLAIRLNCKIPLLYLNRAACHLKLKNLHKAIEDSSKALELltppvaDNA 360
Cdd:COG4783   31 LELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKL------DPE 104

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 255683353 361 NARmkAHVRRGTAFCQLELYVEGLQDYEAALKIDPAN 397
Cdd:COG4783  105 HPE--AYLRLARAYRALGRPDEAIAALEKALELDPDD 139
p23_CacyBP cd06468
p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP) ...
 5-86 2.70e-05

p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter two are components of the ubiquitin ligase that regulates beta-catenin degradation. The beta-catenin gene is an oncogene participating in tumorigenesis in many different cancers. Overexpression of CacyBP/SIP, in part through its effect on the expression of beta-catenin, inhibits the proliferation, tumorigenicity, and invasion of gastric cancer cells. CacyBP/SIP is abundant in neurons and neuroblastoma NB2a cells. An extensive re-organization of microtubules accompanies the differentiation of NB2a cells. CacyBP/SIP may contribute to NB2a cell differentiation through binding to and increasing the oligomerization of tubulin. CacyBP/SIP is also implicated in differentiation of erythroid cells, rat neonatal cardiomyocytes, in mouse endometrial events, and in thymocyte development.


Pssm-ID: 107225  Cd Length: 92  Bit Score: 42.64  E-value: 2.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353   5 VSEFSWQQTPATIFLSLPLRGVcvrdadVFCGESYLKVNFPPFLFELF---------------LYAPIDDGKSKAKIGND 69
Cdd:cd06468    1 ITKYAWDQSDKFVKIYITLKGV------HQLPKENIQVEFTERSFELKvhdlngknyrftinrLLKKIDPEKSSFKVKTD 74

                         90
                 ....*....|....*..
gi 255683353  70 TILFTLYKKEPVLWDSL 86
Cdd:cd06468   75 RIVITLAKKKEKKWESL 91
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 243-395 1.15e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.25  E-value: 1.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353 243 RVFPTALRESQVAEEEEWLHKQAEARRAMSTDLPEFFDLKEEERNPDWLKDKGNKLFATENYLAAVDAYNLAIRLNCKIP 322
Cdd:COG5010    9 RLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNP 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 255683353 323 LLYLNRAACHLKLKNLHKAIEDSSKALELltppvaDNANARmkAHVRRGTAFCQLELYVEGLQDYEAALKIDP 395
Cdd:COG5010   89 ELYYNLALLYSRSGDKDEAKEYYEKALAL------SPDNPN--AYSNLAALLLSLGQDDEAKAALQRALGTSP 153
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 281-407 3.01e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.41  E-value: 3.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353 281 LKEEERNPDWLKDKGNKLFATENYLAAVDAYNLAIRLNCKIPLLYLNRAACHLKLKNLHKAIEDSSKALElltppvADNA 360
Cdd:COG2956  103 LELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALK------LDPD 176

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 255683353 361 NARmkAHVRRGTAFCQLELYVEGLQDYEAALKIDPANTVVQNDAEKI 407
Cdd:COG2956  177 CAR--ALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAEL 221
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 286-412 6.08e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.90  E-value: 6.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353 286 RNPDWLKDKGNKLFATENYLAAVDAYNLAIRLNCKIPLLYLNRAACHLKLKNLHKAIEDSSKALELLtppvADNANARM- 364
Cdd:COG3914  144 DFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELD----PDNADAHSn 219

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 255683353 365 ----KAHVRRGTAFCQLELYVEGLQDYEAALKIDPANTVVQNDAEKIRNIIQ 412
Cdd:COG3914  220 llfaLRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDDDPAELLALAR 271
PTZ00121 PTZ00121
MAEBL; Provisional
 106-270 6.48e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 6.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353  106 QAQEKAKEATEAKAVAKREDQRYALGEMMKIEEEERKKIEDMKENERKKATSELEAWKECQKKADGQKRVQRKEKPLEGK 185
Cdd:PTZ00121 1461 EAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAK 1540

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353  186 QAEETKALKPRglpRKAPPTRLPTRGRNWENifPEKLKEDRVPAPRSAGSIQISFTPRVfptalRESQVAEEEEWLHKQA 265
Cdd:PTZ00121 1541 KAEEKKKADEL---KKAEELKKAEEKKKAEE--AKKAEEDKNMALRKAEEAKKAEEARI-----EEVMKLYEEEKKMKAE 1610


                  ....*
gi 255683353  266 EARRA 270
Cdd:PTZ00121 1611 EAKKA 1615
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
281-410 7.45e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.76  E-value: 7.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353 281 LKEEERNPDWLKDKGNKLFATENYLAAVDAYNLAIRLNCKIPLLYLNRAACHLKLKNLHKAIEDSSKALELLTPPVADNA 360
Cdd:COG0457  103 LELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAA 182

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 255683353 361 NARMKAHVRRGTAFCQLELYVEGLQDYEAALKIDPANTVVQNDAEKIRNI 410
Cdd:COG0457  183 LGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLA 232
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 215-397 1.35e-03

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 41.12  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353  215 ENIFPEKL--KEDRVPAPRSAGSIQISFTPRVFPTALRESQVAEEEEWLHKQAEARRAMSTDLPEFFD----LKEEERNP 288
Cdd:TIGR00990 244 ESKAKEILetKPENLPSVTFVGNYLQSFRPKPRPAGLEDSNELDEETGNGQLQLGLKSPESKADESYEeaarAFEKALDL 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353  289 DWLKDK--------GNKLFATENYLAAVDAYNLAIRLNCKIPLLYLNRAACHLKLKNLHKAIEDSSKALELltppvaDNA 360
Cdd:TIGR00990 324 GKLGEKeaialnlrGTFKCLKGKHLEALADLSKSIELDPRVTQSYIKRASMNLELGDPDKAEEDFDKALKL------NSE 397

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 255683353  361 NARMKAHvrRGTAFCQLELYVEGLQDYEAALKIDPAN 397
Cdd:TIGR00990 398 DPDIYYH--RAQLHFIKGEFAQAGKDYQKSIDLDPDF 432
TPR_1 pfam00515
Tetratricopeptide repeat;
322-351 3.78e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 34.70  E-value: 3.78e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 255683353  322 PLLYLNRAACHLKLKNLHKAIEDSSKALEL 351
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALEL 30
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
298-396 3.94e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.30  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353 298 LFATENYLAAVDAYNLAIRLNCKIPLLYLNRAACHLKLKNLHKAIEdSSKALELltppvaDNANARmkAHVRRGTAFCQL 377
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKL------DPNNAE--ALLNLAELLLEL 72

                         90
                 ....*....|....*....
gi 255683353 378 ELYVEGLQDYEAALKIDPA 396
Cdd:COG3063   73 GDYDEALAYLERALELDPS 91
TPR_1 pfam00515
Tetratricopeptide repeat;
365-397 4.25e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 34.70  E-value: 4.25e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 255683353  365 KAHVRRGTAFCQLELYVEGLQDYEAALKIDPAN 397
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
p23_hB-ind1_like cd06465
p23_like domain found in human (h) butyrate-induced transcript 1 (B-ind1) and similar proteins. ...
 7-80 5.43e-03

p23_like domain found in human (h) butyrate-induced transcript 1 (B-ind1) and similar proteins. hB-ind1 participates in signaling by the small GTPase Rac1. It binds to Rac1 and enhances different Rac1 effects including activation of nuclear factor (NF) kappaB and activation of c-Jun N-terminal kinase (JNK). hB-ind1 also plays a part in the RNA replication and particle production of Hepatitis C virus (HCV) through its interaction with heat shock protein Hsp90, HCV nonstructural protein 5A (NS5A), and the immunophilin FKBP8. hB-ind1 is upregulated in the outer layer of Chinese hamster V79 cells grown as multicell spheroids, versus in the same cells grown as monolayers. This group includes the Saccharomyces cerevisiae Sba1, a co-chaperone of the Hsp90. Sba1 has been shown to be is required for telomere length maintenance, and may modulate telomerase DNA-binding activity.


Pssm-ID: 107222 [Multi-domain]  Cd Length: 108  Bit Score: 36.42  E-value: 5.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353   7 EFSWQQTPATIFLSLPLRgvCVRDADVFCGESYLK------VNFPPFLFELFLYAPIDDGKSKAKIGNDTILFTLYKKEP 80
Cdd:cd06465    2 PVLWAQRSDVVYLTIELP--DAKDPKIKLEPTSLSfkakggGGGKKYEFDLEFYKEIDPEESKYKVTGRQIEFVLRKKEA 79
PTZ00121 PTZ00121
MAEBL; Provisional
 102-202 7.12e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 7.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683353  102 KSILQAQEKAKEATEAKAVAKREDQRYALGEMMKIEEEERKKIEDMKENERKKATSELEAWKEcQKKADGQKRVQRKEKP 181
Cdd:PTZ00121 1302 KKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEE-KAEAAEKKKEEAKKKA 1380

                          90       100
                  ....*....|....*....|..
gi 255683353  182 LEG-KQAEETKalKPRGLPRKA 202
Cdd:PTZ00121 1381 DAAkKKAEEKK--KADEAKKKA 1400
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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