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Conserved domains on  [gi|13386136|ref|NP_080924|]
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dynein axonemal assembly factor 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 106-290 4.57e-41

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 148.78  E-value: 4.57e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 106 LYLHFKGFDRIENLEEYTGLRCLWLECNGIQRIENLQAQSELRCLFLQVNLLHKIENLEPLQKLDALNLSNNYIKTIENL 185
Cdd:cd21340   7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 186 SCLPVLNTLQM------------------------------AHNRLETVADIEHLReclRLCVLDLSHNALSD-PEILSV 234
Cdd:cd21340  87 ENLTNLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLAPLR---NLEQLDASNNQISDlEELLDL 163

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13386136 235 LESMPCLRVLNLMGNPVTKhIPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWAR 290
Cdd:cd21340 164 LSSWPSLRELDLTGNPVCK-KPKYRDKIILASKSLEVLDGKEITDTERQFLKRLKA 218
Borrelia_P83 super family cl26956
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 280-479 4.06e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


The actual alignment was detected with superfamily member pfam05262:

Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 39.99  E-value: 4.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136   280 KDRACAEAWARGGYAAEKEERRQWESREHKKITDSLEALAMIKRRA-----EERKKARDRGETPLPDSEGSIPTSPEAEE 354
Cdd:pfam05262 204 KERESQEDAKRAQQLKEELDKKQIDADKAQQKADFAQDNADKQRDEvrqkqQEAKNLPKPADTSSPKEDKQVAENQKREI 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136   355 KQPMGEIQKKMELFVEESFEAKDELFPETPGGEKELHVVVVNGAVENPDLSGSLAHnqtpvvVTPEESTSPVAATDGART 434
Cdd:pfam05262 284 EKAQIEIKKNDEEALKAKDHKAFDLKQESKASEKEAEDKELEAQKKREPVAEDLQK------TKPQVEAQPTSLNEDAID 357

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 13386136   435 EDIEAVAVEIkerlfIDDLPDLEDAEGTDVSVEDQIKETDIPRIQ 479
Cdd:pfam05262 358 SSNPVYGLKV-----VDPITNLSELVLIDLKTEVRLRESAQQTIR 397
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 106-290 4.57e-41

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 148.78  E-value: 4.57e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 106 LYLHFKGFDRIENLEEYTGLRCLWLECNGIQRIENLQAQSELRCLFLQVNLLHKIENLEPLQKLDALNLSNNYIKTIENL 185
Cdd:cd21340   7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 186 SCLPVLNTLQM------------------------------AHNRLETVADIEHLReclRLCVLDLSHNALSD-PEILSV 234
Cdd:cd21340  87 ENLTNLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLAPLR---NLEQLDASNNQISDlEELLDL 163

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13386136 235 LESMPCLRVLNLMGNPVTKhIPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWAR 290
Cdd:cd21340 164 LSSWPSLRELDLTGNPVCK-KPKYRDKIILASKSLEVLDGKEITDTERQFLKRLKA 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-273 3.47e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 3.47e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 105 TLYLHFKGFDRI-ENLEEYTGLRCLWLECNGIQRI-ENLQAQSELRCLFLQVNLLHKI-ENLEPLQKLDALNLSNNYIKT 181
Cdd:COG4886 117 SLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITD 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 182 I-ENLSCLPVLNTLQMAHNRLETVAdiEHLRECLRLCVLDLSHNALSDpeiLSVLESMPCLRVLNLMGNPVTkHIPNyrr 260
Cdd:COG4886 197 LpEPLGNLTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLTD---LPELGNLTNLEELDLSNNQLT-DLPP--- 267

                       170
                ....*....|...
gi 13386136 261 tvTVRLKHLTYLD 273
Cdd:COG4886 268 --LANLTNLKTLD 278
LRR_9 pfam14580
Leucine-rich repeat;
160-296 1.89e-13

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 69.02  E-value: 1.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136   160 IENL-EPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNRLETVAdiEHLRECL-RLCVLDLSHNALSDPEILSVLES 237
Cdd:pfam14580  34 IENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIG--EGLGEALpNLTELILTNNNLQELGDLDPLAS 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 13386136   238 MPCLRVLNLMGNPVTKHiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYAAE 296
Cdd:pfam14580 112 LKKLTFLSLLRNPVTNK-PHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQ 169
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 167-268 2.38e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 2.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136  167 QKLDALNLSNNYIKTI--ENLSCLPVLNTLQMAHNRLETVADIEhLRECLRLCVLDLSHNALSDpEILSVLESMPCLRVL 244
Cdd:PLN00113 475 KRLENLDLSRNQFSGAvpRKLGSLSELMQLKLSENKLSGEIPDE-LSSCKKLVSLDLSHNQLSG-QIPASFSEMPVLSQL 552

                         90       100
                 ....*....|....*....|....*...
gi 13386136  245 NLMGNPVTKHIP----NYRRTVTVRLKH 268
Cdd:PLN00113 553 DLSQNQLSGEIPknlgNVESLVQVNISH 580
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 280-479 4.06e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 39.99  E-value: 4.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136   280 KDRACAEAWARGGYAAEKEERRQWESREHKKITDSLEALAMIKRRA-----EERKKARDRGETPLPDSEGSIPTSPEAEE 354
Cdd:pfam05262 204 KERESQEDAKRAQQLKEELDKKQIDADKAQQKADFAQDNADKQRDEvrqkqQEAKNLPKPADTSSPKEDKQVAENQKREI 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136   355 KQPMGEIQKKMELFVEESFEAKDELFPETPGGEKELHVVVVNGAVENPDLSGSLAHnqtpvvVTPEESTSPVAATDGART 434
Cdd:pfam05262 284 EKAQIEIKKNDEEALKAKDHKAFDLKQESKASEKEAEDKELEAQKKREPVAEDLQK------TKPQVEAQPTSLNEDAID 357

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 13386136   435 EDIEAVAVEIkerlfIDDLPDLEDAEGTDVSVEDQIKETDIPRIQ 479
Cdd:pfam05262 358 SSNPVYGLKV-----VDPITNLSELVLIDLKTEVRLRESAQQTIR 397
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 106-290 4.57e-41

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 148.78  E-value: 4.57e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 106 LYLHFKGFDRIENLEEYTGLRCLWLECNGIQRIENLQAQSELRCLFLQVNLLHKIENLEPLQKLDALNLSNNYIKTIENL 185
Cdd:cd21340   7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 186 SCLPVLNTLQM------------------------------AHNRLETVADIEHLReclRLCVLDLSHNALSD-PEILSV 234
Cdd:cd21340  87 ENLTNLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLAPLR---NLEQLDASNNQISDlEELLDL 163

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13386136 235 LESMPCLRVLNLMGNPVTKhIPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWAR 290
Cdd:cd21340 164 LSSWPSLRELDLTGNPVCK-KPKYRDKIILASKSLEVLDGKEITDTERQFLKRLKA 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-273 3.47e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 3.47e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 105 TLYLHFKGFDRI-ENLEEYTGLRCLWLECNGIQRI-ENLQAQSELRCLFLQVNLLHKI-ENLEPLQKLDALNLSNNYIKT 181
Cdd:COG4886 117 SLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITD 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 182 I-ENLSCLPVLNTLQMAHNRLETVAdiEHLRECLRLCVLDLSHNALSDpeiLSVLESMPCLRVLNLMGNPVTkHIPNyrr 260
Cdd:COG4886 197 LpEPLGNLTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLTD---LPELGNLTNLEELDLSNNQLT-DLPP--- 267

                       170
                ....*....|...
gi 13386136 261 tvTVRLKHLTYLD 273
Cdd:COG4886 268 --LANLTNLKTLD 278
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-252 1.33e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 1.33e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 105 TLYLHFKGFDRI-ENLEEYTGLRCLWLECNGIQRI-ENLQAQSELRCLFLQVNLLHKI-ENLEPLQKLDALNLSNNYIKT 181
Cdd:COG4886 140 ELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTD 219

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13386136 182 I-ENLSCLPVLNTLQMAHNRLETVADIEHLReclRLCVLDLSHNALSDpeiLSVLESMPCLRVLNLMGNPVT 252
Cdd:COG4886 220 LpEPLANLTNLETLDLSNNQLTDLPELGNLT---NLEELDLSNNQLTD---LPPLANLTNLKTLDLSNNQLT 285
LRR_9 pfam14580
Leucine-rich repeat;
160-296 1.89e-13

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 69.02  E-value: 1.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136   160 IENL-EPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNRLETVAdiEHLRECL-RLCVLDLSHNALSDPEILSVLES 237
Cdd:pfam14580  34 IENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIG--EGLGEALpNLTELILTNNNLQELGDLDPLAS 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 13386136   238 MPCLRVLNLMGNPVTKHiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYAAE 296
Cdd:pfam14580 112 LKKLTFLSLLRNPVTNK-PHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQ 169
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-237 1.31e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 1.31e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 105 TLYLHFKGFDRI-ENLEEYTGLRCLWLECNGIQRI-ENLQAQSELRCLFLQVNLLHKI-ENLEPLQKLDALNLSNNYIKT 181
Cdd:COG4886 163 SLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTD 242

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13386136 182 IENLSCLPVLNTLQMAHNRLETVADIEHLReclRLCVLDLSHNALSDPEILSVLES 237
Cdd:COG4886 243 LPELGNLTNLEELDLSNNQLTDLPPLANLT---NLKTLDLSNNQLTDLKLKELELL 295
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-273 2.08e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 2.08e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136  95 KLYVTPALNDTLYLHFKGFDRIENLEEYTGLRCLWLECNGIQRIENLQAQSELRCLFLQVNllhkiENLEPLQKLDALNL 174
Cdd:COG4886  46 LLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDL 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 175 SNNYIKTI-ENLSCLPVLNTLQMAHNRLETVAdiEHLRECLRLCVLDLSHNALSD-PEILSVLESmpcLRVLNLMGNPVT 252
Cdd:COG4886 121 SGNQLTDLpEELANLTNLKELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLTDlPEELGNLTN---LKELDLSNNQIT 195

                       170       180
                ....*....|....*....|.
gi 13386136 253 KhIPNyrrTVTvRLKHLTYLD 273
Cdd:COG4886 196 D-LPE---PLG-NLTNLEELD 211
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-232 1.15e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 1.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 105 TLYLHFKGFDRI-ENLEEYTGLRCLWLECNGIQRI-ENLQAQSELRCLFLQVNLLHKIENLEPLQKLDALNLSNNYIKTI 182
Cdd:COG4886 186 ELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL 265

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 13386136 183 ENLSCLPVLNTLQMAHNRLeTVADIEHLRECLRLCVLDLSHNALSDPEIL 232
Cdd:COG4886 266 PPLANLTNLKTLDLSNNQL-TDLKLKELELLLGLNSLLLLLLLLNLLELL 314
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
101-273 6.29e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.32  E-value: 6.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 101 ALNDTLYLHFKGFDRIENLEEYTGLRCLWLECNGIQRIENLQAQSELRCLFLQVNLLHKIENLEPLQKLDALNLSNNyik 180
Cdd:COG4886  30 LLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN--- 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 181 tiENLSCLPVLNTLQMAHNRLETV-ADIEHLREcLRlcVLDLSHNALSDpeILSVLESMPCLRVLNLMGNPVTkHIPNyr 259
Cdd:COG4886 107 --EELSNLTNLESLDLSGNQLTDLpEELANLTN-LK--ELDLSNNQLTD--LPEPLGNLTNLKSLDLSNNQLT-DLPE-- 176

                       170
                ....*....|....
gi 13386136 260 rtVTVRLKHLTYLD 273
Cdd:COG4886 177 --ELGNLTNLKELD 188
LRR_8 pfam13855
Leucine rich repeat;
145-201 8.20e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 8.20e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13386136   145 SELRCLFLQVNLLHKI--ENLEPLQKLDALNLSNNYIKTIEN--LSCLPVLNTLQMAHNRL 201
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
189-251 6.83e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 6.83e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13386136   189 PVLNTLQMAHNRLETVADiEHLRECLRLCVLDLSHNALS--DPEilsVLESMPCLRVLNLMGNPV 251
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTtlSPG---AFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 116-252 2.76e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.58  E-value: 2.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 116 IENLEEYTGLRCLWLECNGIQ-----RIENLQAQSELRCLFLQVNLL------HKIENLEPLQ-KLDALNLSNNyikTIE 183
Cdd:cd00116  74 LQGLTKGCGLQELDLSDNALGpdgcgVLESLLRSSSLQELKLNNNGLgdrglrLLAKGLKDLPpALEKLVLGRN---RLE 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 184 NLSCLPVLNTLQmAHNRLETV---------ADIEHLRECLR----LCVLDLSHNALSDPEI--LS-VLESMPCLRVLNLM 247
Cdd:cd00116 151 GASCEALAKALR-ANRDLKELnlanngigdAGIRALAEGLKancnLEVLDLNNNGLTDEGAsaLAeTLASLKSLEVLNLG 229


                ....*
gi 13386136 248 GNPVT 252
Cdd:cd00116 230 DNNLT 234
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 167-212 7.29e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.31  E-value: 7.29e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 13386136   167 QKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNRLetVADIEHLRE 212
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK--ITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 215-259 7.51e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.31  E-value: 7.51e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 13386136   215 RLCVLDLSHNALSDpeiLSVLESMPCLRVLNLMGNPVTKHIPNYR 259
Cdd:pfam12799   2 NLEVLDLSNNQITD---IPPLAKLPNLETLDLSGNNKITDLSDLA 43
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 147-186 9.42e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 9.42e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 13386136   147 LRCLFLQVNLLHKIENLEPLQKLDALNLS-NNYIKTIENLS 186
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDLA 43
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 116-253 2.00e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.40  E-value: 2.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 116 IENLEEYTGLRCLWLECNGIQR------IENLQAQSELRCLFLQVNllhkienlePLQKLDALNLsnnyiktIENLSCLP 189
Cdd:COG5238 257 AEALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVN---------RIGDEGAIAL-------AEGLQGNK 320

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 190 VLNTLQMAHNRL---ETVADIEHLRECLRLCVLDLSHNALSDP---EILSVLESMPCLRVLNLMGNPVTK 253
Cdd:COG5238 321 TLHTLNLAYNGIgaqGAIALAKALQENTTLHSLDLSDNQIGDEgaiALAKYLEGNTTLRELNLGKNNIGK 390
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 167-268 2.38e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 2.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136  167 QKLDALNLSNNYIKTI--ENLSCLPVLNTLQMAHNRLETVADIEhLRECLRLCVLDLSHNALSDpEILSVLESMPCLRVL 244
Cdd:PLN00113 475 KRLENLDLSRNQFSGAvpRKLGSLSELMQLKLSENKLSGEIPDE-LSSCKKLVSLDLSHNQLSG-QIPASFSEMPVLSQL 552

                         90       100
                 ....*....|....*....|....*...
gi 13386136  245 NLMGNPVTKHIP----NYRRTVTVRLKH 268
Cdd:PLN00113 553 DLSQNQLSGEIPknlgNVESLVQVNISH 580
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 117-254 2.83e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.63  E-value: 2.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 117 ENLEEYTGLRCLWLECNGIQR------IENLQAQSELRCLFLQVN------LLHKIENLEPLQKLDALNLSNNYIKT--- 181
Cdd:COG5238 202 EALTQNTTVTTLWLKRNPIGDegaeilAEALKGNKSLTTLDLSNNqigdegVIALAEALKNNTTVETLYLSGNQIGAega 281

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136 182 ---IENLSCLPVLNTLQMAHNRLE---TVADIEHLRECLRLCVLDLSHNALSDPE---ILSVLESMPCLRVLNLMGNPVT 252
Cdd:COG5238 282 ialAKALQGNTTLTSLDLSVNRIGdegAIALAEGLQGNKTLHTLNLAYNGIGAQGaiaLAKALQENTTLHSLDLSDNQIG 361


                ..
gi 13386136 253 KH 254
Cdd:COG5238 362 DE 363
PLN03150 PLN03150
hypothetical protein; Provisional
 166-256 5.89e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 5.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136  166 LQKLDALNLSNNYIKTIENLSclpvlntlqmahnrLETVADIEhlreclrlcVLDLSHNAL--SDPEILSVLESmpcLRV 243
Cdd:PLN03150 441 LRHLQSINLSGNSIRGNIPPS--------------LGSITSLE---------VLDLSYNSFngSIPESLGQLTS---LRI 494

                         90
                 ....*....|...
gi 13386136  244 LNLMGNPVTKHIP 256
Cdd:PLN03150 495 LNLNGNSLSGRVP 507
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 280-479 4.06e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 39.99  E-value: 4.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136   280 KDRACAEAWARGGYAAEKEERRQWESREHKKITDSLEALAMIKRRA-----EERKKARDRGETPLPDSEGSIPTSPEAEE 354
Cdd:pfam05262 204 KERESQEDAKRAQQLKEELDKKQIDADKAQQKADFAQDNADKQRDEvrqkqQEAKNLPKPADTSSPKEDKQVAENQKREI 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386136   355 KQPMGEIQKKMELFVEESFEAKDELFPETPGGEKELHVVVVNGAVENPDLSGSLAHnqtpvvVTPEESTSPVAATDGART 434
Cdd:pfam05262 284 EKAQIEIKKNDEEALKAKDHKAFDLKQESKASEKEAEDKELEAQKKREPVAEDLQK------TKPQVEAQPTSLNEDAID 357

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 13386136   435 EDIEAVAVEIkerlfIDDLPDLEDAEGTDVSVEDQIKETDIPRIQ 479
Cdd:pfam05262 358 SSNPVYGLKV-----VDPITNLSELVLIDLKTEVRLRESAQQTIR 397
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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