NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|46560565|ref|NP_081411|]
View 

protein transport protein Sec24D [Mus musculus]

Protein Classification

SEC24 family transport protein( domain architecture ID 1001573)

SEC24 family transport protein is a component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5028 super family cl34873
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 116-1027 1.67e-165

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5028:

Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 508.56  E-value: 1.67e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  116 TQLGSQFSSMQINSYGVGATPQSQGPP-----GPQSAGAFQGPPQPAQPSILQPGHQ----VPPPPPTALNGPGASPMSP 186
Cdd:COG5028    2 SQHKKGVYPQAQSQVHTGAASSKKSARphrayANFSAGQMGMPPYTTPPLQQQSRRQidqaATAMHNTGANNPAPSVMSP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  187 pthrqdglpgpaplnaqyqpppppgqtlgpgYPPQQatnygpqmggaqMSYPGGFPGGPAQMAGPAPQLQrkldpdSIPS 266
Cdd:COG5028   82 -------------------------------AFQSQ------------QKFSSPYGGSMADGTAPKPTNP------LVPV 112

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  267 piqVIENDRATRGGQVYTTnTRGQVPPLvTTECVIQDQGHSSPRYIRCTTYCFPCTSDMAKQAQIPLAAVIKPFADIPPN 346
Cdd:COG5028  113 ---DLFEDQPPPISDLFLP-PPPIVPPL-TTNFVGSEQSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYPE 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  347 ETPLYLVNHGEsgPVRCNRCKAYMCPFMQFIEGGRRYQCGFCSCVNEVPPFYFQHLDHIGRRLDHYEKPELSLGSYEYVA 426
Cdd:COG5028  188 EDPVPLVEDGS--IVRCRRCRSYINPFVQFIEQGRKWRCNICRSKNDVPEGFDNPSGPNDPRSDRYSRPELKSGVVDFLA 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  427 TLDYcrKNKPPSPPAFIFMIDVSYSNIKNGLVKLICEELKTALKRLPkeEHEETSaiRVGFITYNKVLHFFNVKSNLaQP 506
Cdd:COG5028  266 PKEY--SLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILENLDQIP--NFDPRT--KIAIICFDSSLHFFKLSPDL-DE 338

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  507 QMMVVTDVGEVFVPLLDG-FLVNYEESQSVIHNLLDQIPEMFADSNENETVFAPviqagmeALKAA-----ECPGKLFIF 580
Cdd:COG5028  339 QMLIVSDLDEPFLPFPSGlFVLPLKSCKQIIETLLDRVPRIFQDNKSPKNALGP-------ALKAAksligGTGGKIIVF 411

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  581 HSSLPTAeAPGKLKNRDDKklvntdkEKILFQPQTAVYESLAKDCVANSCSVTLFLFPSQFVDVASLGLVPLLTGGTLYK 660
Cdd:COG5028  412 LSTLPNM-GIGKLQLREDK-------ESSLLSCKDSFYKEFAIECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYF 483

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  661 YNVFQIHS--DSQRFLTDLRNDIEKKIGFDAIMRVRTSTGFRATDFFGGIFMNNTTDVEMAAIDCDKAVTVEFKHDDKLS 738
Cdd:COG5028  484 YPNFSATRpnDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNRSSDLCAFSTMPRDTSLLVEFSIDEKLM 563

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  739 EDvGALIQCAVLYTTISGQRRLRIHNLALNCSTQLADLYKSCETDALINFFAKSAFKAVLNQPLKAIREILVNQTAHMLA 818
Cdd:COG5028  564 TS-DVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAKKASTKALNSSLKEARVLINKSMVDILK 642

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  819 CYRKHCASPSAASQLILPDSMKVLPVYMNSLLKNcVLLSRSEISPDERAYQRQLVMTMGVADSQLFFYPLLLPIHTL--- 895
Cdd:COG5028  643 AYKKELVKSNTSTQLPLPANLKLLPLLMLALLKS-SAFRSGSTPSDIRISALNRLTSLPLKQLMRNIYPTLYALHDMpie 721

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  896 ----DVKSAALPPAVRCSESRLSEEGIFLLANGLNMFLWFGVGSPPELIQGIFNVPSFAHINTDMTSLPEVGSPHSQQLR 971
Cdd:COG5028  722 aglpDEGLLVLPSPINATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDLFGVDSLSDIPSGKFTLPPTGNEFNERVR 801

                        890       900       910       920       930
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 46560565  972 MIMNNIQQKKPYS-MKLIVVKQ--REQREMAFRQFLVEDKgLYGGSSYVDFLCCVHKEI 1027
Cdd:COG5028  802 NIIGELRSVNDDStLPLVLVRGggDPSLRLWFFSTLVEDK-TLNIPSYLDYLQILHEKI 859
 
Name Accession Description Interval E-value
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 116-1027 1.67e-165

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 508.56  E-value: 1.67e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  116 TQLGSQFSSMQINSYGVGATPQSQGPP-----GPQSAGAFQGPPQPAQPSILQPGHQ----VPPPPPTALNGPGASPMSP 186
Cdd:COG5028    2 SQHKKGVYPQAQSQVHTGAASSKKSARphrayANFSAGQMGMPPYTTPPLQQQSRRQidqaATAMHNTGANNPAPSVMSP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  187 pthrqdglpgpaplnaqyqpppppgqtlgpgYPPQQatnygpqmggaqMSYPGGFPGGPAQMAGPAPQLQrkldpdSIPS 266
Cdd:COG5028   82 -------------------------------AFQSQ------------QKFSSPYGGSMADGTAPKPTNP------LVPV 112

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  267 piqVIENDRATRGGQVYTTnTRGQVPPLvTTECVIQDQGHSSPRYIRCTTYCFPCTSDMAKQAQIPLAAVIKPFADIPPN 346
Cdd:COG5028  113 ---DLFEDQPPPISDLFLP-PPPIVPPL-TTNFVGSEQSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYPE 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  347 ETPLYLVNHGEsgPVRCNRCKAYMCPFMQFIEGGRRYQCGFCSCVNEVPPFYFQHLDHIGRRLDHYEKPELSLGSYEYVA 426
Cdd:COG5028  188 EDPVPLVEDGS--IVRCRRCRSYINPFVQFIEQGRKWRCNICRSKNDVPEGFDNPSGPNDPRSDRYSRPELKSGVVDFLA 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  427 TLDYcrKNKPPSPPAFIFMIDVSYSNIKNGLVKLICEELKTALKRLPkeEHEETSaiRVGFITYNKVLHFFNVKSNLaQP 506
Cdd:COG5028  266 PKEY--SLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILENLDQIP--NFDPRT--KIAIICFDSSLHFFKLSPDL-DE 338

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  507 QMMVVTDVGEVFVPLLDG-FLVNYEESQSVIHNLLDQIPEMFADSNENETVFAPviqagmeALKAA-----ECPGKLFIF 580
Cdd:COG5028  339 QMLIVSDLDEPFLPFPSGlFVLPLKSCKQIIETLLDRVPRIFQDNKSPKNALGP-------ALKAAksligGTGGKIIVF 411

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  581 HSSLPTAeAPGKLKNRDDKklvntdkEKILFQPQTAVYESLAKDCVANSCSVTLFLFPSQFVDVASLGLVPLLTGGTLYK 660
Cdd:COG5028  412 LSTLPNM-GIGKLQLREDK-------ESSLLSCKDSFYKEFAIECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYF 483

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  661 YNVFQIHS--DSQRFLTDLRNDIEKKIGFDAIMRVRTSTGFRATDFFGGIFMNNTTDVEMAAIDCDKAVTVEFKHDDKLS 738
Cdd:COG5028  484 YPNFSATRpnDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNRSSDLCAFSTMPRDTSLLVEFSIDEKLM 563

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  739 EDvGALIQCAVLYTTISGQRRLRIHNLALNCSTQLADLYKSCETDALINFFAKSAFKAVLNQPLKAIREILVNQTAHMLA 818
Cdd:COG5028  564 TS-DVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAKKASTKALNSSLKEARVLINKSMVDILK 642

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  819 CYRKHCASPSAASQLILPDSMKVLPVYMNSLLKNcVLLSRSEISPDERAYQRQLVMTMGVADSQLFFYPLLLPIHTL--- 895
Cdd:COG5028  643 AYKKELVKSNTSTQLPLPANLKLLPLLMLALLKS-SAFRSGSTPSDIRISALNRLTSLPLKQLMRNIYPTLYALHDMpie 721

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  896 ----DVKSAALPPAVRCSESRLSEEGIFLLANGLNMFLWFGVGSPPELIQGIFNVPSFAHINTDMTSLPEVGSPHSQQLR 971
Cdd:COG5028  722 aglpDEGLLVLPSPINATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDLFGVDSLSDIPSGKFTLPPTGNEFNERVR 801

                        890       900       910       920       930
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 46560565  972 MIMNNIQQKKPYS-MKLIVVKQ--REQREMAFRQFLVEDKgLYGGSSYVDFLCCVHKEI 1027
Cdd:COG5028  802 NIIGELRSVNDDStLPLVLVRGggDPSLRLWFFSTLVEDK-TLNIPSYLDYLQILHEKI 859
Sec24-like cd01479
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
 437-696 6.07e-114

Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238756 [Multi-domain]  Cd Length: 244  Bit Score: 351.58  E-value: 6.07e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  437 PSPPAFIFMIDVSYSNIKNGLVKLICEELKTALKRLPKEEheetSAIRVGFITYNKVLHFFNVKSNLAQPQMMVVTDVGE 516
Cdd:cd01479    1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDD----PRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDD 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  517 VFVPLLDGFLVNYEESQSVIHNLLDQIPEMFADSNENETVFAPVIQAGMEALKaaECPGKLFIFHSSLPTAEApGKLKNR 596
Cdd:cd01479   77 PFLPLPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLK--ETGGKIIVFQSSLPTLGA-GKLKSR 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  597 DDKKLVNTDKEKILFQPQTAVYESLAKDCVANSCSVTLFLFPSQFVDVASLGLVPLLTGGTLYKYnvfqihsdsQRFLTD 676
Cdd:cd01479  154 EDPKLLSTDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYY---------PSFNFS 224

                        250       260
                 ....*....|....*....|
gi 46560565  677 LRNDIEKKIGFDAIMRVRTS 696
Cdd:cd01479  225 APNDVEKLVNELARYLTRKI 244
Sec23_trunk pfam04811
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 437-681 9.06e-107

Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.


Pssm-ID: 398467 [Multi-domain]  Cd Length: 241  Bit Score: 332.29  E-value: 9.06e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565    437 PSPPAFIFMIDVSYSNIKNGLVKLICEELKTALKRLPKEEHeetsaIRVGFITYNKVLHFFNVKSNLAQPQMMVVTDVGE 516
Cdd:pfam04811    1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPR-----ARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQD 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565    517 VFVPLLDGFLVNYEESQSVIHNLLDQIPEMFADSNENETVFAPVIQAGMEALKAAECPGKLFIFHSSLPTAEAPGKLKNR 596
Cdd:pfam04811   76 MFLPLPDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLKAAFTGGKIMVFQGGLPTVGPGGKLKSR 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565    597 DDKKLVNTDKEKILFQPQT-AVYESLAKDCVANSCSVTLFLFPSQFVDVASLGLVPLLTGGTLYKYNVFQIHSDSQRFLT 675
Cdd:pfam04811  156 LDESHHGTDKEKAKLVKKAdKFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADVDGSKFKQ 235


                   ....*.
gi 46560565    676 DLRNDI 681
Cdd:pfam04811  236 DLQRYF 241
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 439-1025 2.79e-48

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 187.97  E-value: 2.79e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565   439 PPAFIFMIDVSYSNIKNGLVKLICEELKTALK--RLPKeeheetsaIRVGFITYNKVLHFFNVKSNLAQP---------- 506
Cdd:PTZ00395  952 PPYFVFVVECSYNAIYNNITYTILEGIRYAVQnvKCPQ--------TKIAIITFNSSIYFYHCKGGKGVSgeegdggggs 1023

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565   507 ---QMMVVTDVGEVFVPL-LDGFLVNYEESQSVIHNLLDQIPEMFADSNENETVFAPVIQAGMEALKAAECPGKLFIFHS 582
Cdd:PTZ00395 1024 gnhQVIVMSDVDDPFLPLpLEDLFFGCVEEIDKINTLIDTIKSVSTTMQSYGSCGNSALKIAMDMLKERNGLGSICMFYT 1103

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565   583 SLPTAeAPGKLKnrddkKLVNTDKEKILFQPQTAVYESLAKDCVANSCSVTLFLFPSQFVDVA--SLGLVPLLTGGTLYK 660
Cdd:PTZ00395 1104 TTPNC-GIGAIK-----ELKKDLQENFLEVKQKIFYDSLLLDLYAFNISVDIFIISSNNVRVCvpSLQYVAQNTGGKILF 1177

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565   661 YNVFQIHSDSQRFLTDLRNDI-EKKIGFDAIMRVRTSTG------FRATDFFGGIFMNNTtdVEMAAIDCDKAVTVEFKH 733
Cdd:PTZ00395 1178 VENFLWQKDYKEIYMNIMDTLtSEDIAYCCELKLRYSHHmsvkklFCCNNNFNSIISVDT--IKIPKIRHDQTFAFLLNY 1255

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565   734 DDKLSEDVGALIQCAVLYTTISGQRRLRIHNLALNCSTQLADLYKSCETDALINFFAKSAFKAVLNQplKAIREILVNQT 813
Cdd:PTZ00395 1256 SDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFRYTDAEALMNILIKQLCTNILHN--DNYSKIIIDNL 1333

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565   814 AHMLACYRKHCASPSAASQLILPDSMKVLPVYMNSLLKNCVllSRSEISPDERAYQRQLVMTMGVADSQLFFYPLLLPIH 893
Cdd:PTZ00395 1334 AAILFSYRINCASSAHSGQLILPDTLKLLPLFTSSLLKHNV--TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYVIH 1411

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565   894 ---------TLDVKSAA-LPPAVRCSESRLSEEGIFLLANGLNMFLWFGVGSPPELIQGIF-NVPSfahiNTDMTSLPEV 962
Cdd:PTZ00395 1412 ikgktneidSMDVDDDLfIPKTIPSSAEKIYSNGIYLLDACTHFYLYFGFHSDANFAKEIVgDIPT----EKNAHELNLT 1487

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46560565   963 GSPHSQQLRMIMNNIQQKKPYS--MKLIVVKQREQREMAFRQFLVEDKGlYGGSSYVDFLCCVHK 1025
Cdd:PTZ00395 1488 DTPNAQKVQRIIKNLSRIHHFNkyVPLVMVAPKSNEEEHLISLCVEDKA-DKEYSYVNFLCFIHK 1551
 
Name Accession Description Interval E-value
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 116-1027 1.67e-165

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 508.56  E-value: 1.67e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  116 TQLGSQFSSMQINSYGVGATPQSQGPP-----GPQSAGAFQGPPQPAQPSILQPGHQ----VPPPPPTALNGPGASPMSP 186
Cdd:COG5028    2 SQHKKGVYPQAQSQVHTGAASSKKSARphrayANFSAGQMGMPPYTTPPLQQQSRRQidqaATAMHNTGANNPAPSVMSP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  187 pthrqdglpgpaplnaqyqpppppgqtlgpgYPPQQatnygpqmggaqMSYPGGFPGGPAQMAGPAPQLQrkldpdSIPS 266
Cdd:COG5028   82 -------------------------------AFQSQ------------QKFSSPYGGSMADGTAPKPTNP------LVPV 112

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  267 piqVIENDRATRGGQVYTTnTRGQVPPLvTTECVIQDQGHSSPRYIRCTTYCFPCTSDMAKQAQIPLAAVIKPFADIPPN 346
Cdd:COG5028  113 ---DLFEDQPPPISDLFLP-PPPIVPPL-TTNFVGSEQSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYPE 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  347 ETPLYLVNHGEsgPVRCNRCKAYMCPFMQFIEGGRRYQCGFCSCVNEVPPFYFQHLDHIGRRLDHYEKPELSLGSYEYVA 426
Cdd:COG5028  188 EDPVPLVEDGS--IVRCRRCRSYINPFVQFIEQGRKWRCNICRSKNDVPEGFDNPSGPNDPRSDRYSRPELKSGVVDFLA 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  427 TLDYcrKNKPPSPPAFIFMIDVSYSNIKNGLVKLICEELKTALKRLPkeEHEETSaiRVGFITYNKVLHFFNVKSNLaQP 506
Cdd:COG5028  266 PKEY--SLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILENLDQIP--NFDPRT--KIAIICFDSSLHFFKLSPDL-DE 338

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  507 QMMVVTDVGEVFVPLLDG-FLVNYEESQSVIHNLLDQIPEMFADSNENETVFAPviqagmeALKAA-----ECPGKLFIF 580
Cdd:COG5028  339 QMLIVSDLDEPFLPFPSGlFVLPLKSCKQIIETLLDRVPRIFQDNKSPKNALGP-------ALKAAksligGTGGKIIVF 411

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  581 HSSLPTAeAPGKLKNRDDKklvntdkEKILFQPQTAVYESLAKDCVANSCSVTLFLFPSQFVDVASLGLVPLLTGGTLYK 660
Cdd:COG5028  412 LSTLPNM-GIGKLQLREDK-------ESSLLSCKDSFYKEFAIECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYF 483

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  661 YNVFQIHS--DSQRFLTDLRNDIEKKIGFDAIMRVRTSTGFRATDFFGGIFMNNTTDVEMAAIDCDKAVTVEFKHDDKLS 738
Cdd:COG5028  484 YPNFSATRpnDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNRSSDLCAFSTMPRDTSLLVEFSIDEKLM 563

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  739 EDvGALIQCAVLYTTISGQRRLRIHNLALNCSTQLADLYKSCETDALINFFAKSAFKAVLNQPLKAIREILVNQTAHMLA 818
Cdd:COG5028  564 TS-DVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAKKASTKALNSSLKEARVLINKSMVDILK 642

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  819 CYRKHCASPSAASQLILPDSMKVLPVYMNSLLKNcVLLSRSEISPDERAYQRQLVMTMGVADSQLFFYPLLLPIHTL--- 895
Cdd:COG5028  643 AYKKELVKSNTSTQLPLPANLKLLPLLMLALLKS-SAFRSGSTPSDIRISALNRLTSLPLKQLMRNIYPTLYALHDMpie 721

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  896 ----DVKSAALPPAVRCSESRLSEEGIFLLANGLNMFLWFGVGSPPELIQGIFNVPSFAHINTDMTSLPEVGSPHSQQLR 971
Cdd:COG5028  722 aglpDEGLLVLPSPINATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDLFGVDSLSDIPSGKFTLPPTGNEFNERVR 801

                        890       900       910       920       930
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 46560565  972 MIMNNIQQKKPYS-MKLIVVKQ--REQREMAFRQFLVEDKgLYGGSSYVDFLCCVHKEI 1027
Cdd:COG5028  802 NIIGELRSVNDDStLPLVLVRGggDPSLRLWFFSTLVEDK-TLNIPSYLDYLQILHEKI 859
Sec24-like cd01479
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
 437-696 6.07e-114

Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238756 [Multi-domain]  Cd Length: 244  Bit Score: 351.58  E-value: 6.07e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  437 PSPPAFIFMIDVSYSNIKNGLVKLICEELKTALKRLPKEEheetSAIRVGFITYNKVLHFFNVKSNLAQPQMMVVTDVGE 516
Cdd:cd01479    1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDD----PRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDD 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  517 VFVPLLDGFLVNYEESQSVIHNLLDQIPEMFADSNENETVFAPVIQAGMEALKaaECPGKLFIFHSSLPTAEApGKLKNR 596
Cdd:cd01479   77 PFLPLPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLK--ETGGKIIVFQSSLPTLGA-GKLKSR 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  597 DDKKLVNTDKEKILFQPQTAVYESLAKDCVANSCSVTLFLFPSQFVDVASLGLVPLLTGGTLYKYnvfqihsdsQRFLTD 676
Cdd:cd01479  154 EDPKLLSTDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYY---------PSFNFS 224

                        250       260
                 ....*....|....*....|
gi 46560565  677 LRNDIEKKIGFDAIMRVRTS 696
Cdd:cd01479  225 APNDVEKLVNELARYLTRKI 244
Sec23_trunk pfam04811
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 437-681 9.06e-107

Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.


Pssm-ID: 398467 [Multi-domain]  Cd Length: 241  Bit Score: 332.29  E-value: 9.06e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565    437 PSPPAFIFMIDVSYSNIKNGLVKLICEELKTALKRLPKEEHeetsaIRVGFITYNKVLHFFNVKSNLAQPQMMVVTDVGE 516
Cdd:pfam04811    1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPR-----ARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQD 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565    517 VFVPLLDGFLVNYEESQSVIHNLLDQIPEMFADSNENETVFAPVIQAGMEALKAAECPGKLFIFHSSLPTAEAPGKLKNR 596
Cdd:pfam04811   76 MFLPLPDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLKAAFTGGKIMVFQGGLPTVGPGGKLKSR 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565    597 DDKKLVNTDKEKILFQPQT-AVYESLAKDCVANSCSVTLFLFPSQFVDVASLGLVPLLTGGTLYKYNVFQIHSDSQRFLT 675
Cdd:pfam04811  156 LDESHHGTDKEKAKLVKKAdKFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADVDGSKFKQ 235


                   ....*.
gi 46560565    676 DLRNDI 681
Cdd:pfam04811  236 DLQRYF 241
trunk_domain cd01468
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ...
 437-677 6.69e-95

trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.


Pssm-ID: 238745 [Multi-domain]  Cd Length: 239  Bit Score: 300.70  E-value: 6.69e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  437 PSPPAFIFMIDVSYSNIKNGLVKLICEELKTALKRLPKEEHeetsaIRVGFITYNKVLHFFNVKSNLAQPQMMVVTDVGE 516
Cdd:cd01468    1 PQPPVFVFVIDVSYEAIKEGLLQALKESLLASLDLLPGDPR-----ARVGLITYDSTVHFYNLSSDLAQPKMYVVSDLKD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  517 VFVPLLDGFLVNYEESQSVIHNLLDQIPEMFAD--SNENETVFAPVIQAGMEALKAAECPGKLFIFHSSLPTAEaPGKLK 594
Cdd:cd01468   76 VFLPLPDRFLVPLSECKKVIHDLLEQLPPMFWPvpTHRPERCLGPALQAAFLLLKGTFAGGRIIVFQGGLPTVG-PGKLK 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  595 NRDDKKLVNTDKEKILFQPQTAVYESLAKDCVANSCSVTLFLFPSQFVDVASLGLVPLLTGGTLYKYNVFQIHSDSQRFL 674
Cdd:cd01468  155 SREDKEPIRSHDEAQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVDVATLKQLAKSTGGQVYLYDSFQAPNDGSKFK 234


                 ...
gi 46560565  675 TDL 677
Cdd:cd01468  235 QDL 237
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 439-1025 2.79e-48

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 187.97  E-value: 2.79e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565   439 PPAFIFMIDVSYSNIKNGLVKLICEELKTALK--RLPKeeheetsaIRVGFITYNKVLHFFNVKSNLAQP---------- 506
Cdd:PTZ00395  952 PPYFVFVVECSYNAIYNNITYTILEGIRYAVQnvKCPQ--------TKIAIITFNSSIYFYHCKGGKGVSgeegdggggs 1023

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565   507 ---QMMVVTDVGEVFVPL-LDGFLVNYEESQSVIHNLLDQIPEMFADSNENETVFAPVIQAGMEALKAAECPGKLFIFHS 582
Cdd:PTZ00395 1024 gnhQVIVMSDVDDPFLPLpLEDLFFGCVEEIDKINTLIDTIKSVSTTMQSYGSCGNSALKIAMDMLKERNGLGSICMFYT 1103

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565   583 SLPTAeAPGKLKnrddkKLVNTDKEKILFQPQTAVYESLAKDCVANSCSVTLFLFPSQFVDVA--SLGLVPLLTGGTLYK 660
Cdd:PTZ00395 1104 TTPNC-GIGAIK-----ELKKDLQENFLEVKQKIFYDSLLLDLYAFNISVDIFIISSNNVRVCvpSLQYVAQNTGGKILF 1177

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565   661 YNVFQIHSDSQRFLTDLRNDI-EKKIGFDAIMRVRTSTG------FRATDFFGGIFMNNTtdVEMAAIDCDKAVTVEFKH 733
Cdd:PTZ00395 1178 VENFLWQKDYKEIYMNIMDTLtSEDIAYCCELKLRYSHHmsvkklFCCNNNFNSIISVDT--IKIPKIRHDQTFAFLLNY 1255

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565   734 DDKLSEDVGALIQCAVLYTTISGQRRLRIHNLALNCSTQLADLYKSCETDALINFFAKSAFKAVLNQplKAIREILVNQT 813
Cdd:PTZ00395 1256 SDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFRYTDAEALMNILIKQLCTNILHN--DNYSKIIIDNL 1333

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565   814 AHMLACYRKHCASPSAASQLILPDSMKVLPVYMNSLLKNCVllSRSEISPDERAYQRQLVMTMGVADSQLFFYPLLLPIH 893
Cdd:PTZ00395 1334 AAILFSYRINCASSAHSGQLILPDTLKLLPLFTSSLLKHNV--TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYVIH 1411

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565   894 ---------TLDVKSAA-LPPAVRCSESRLSEEGIFLLANGLNMFLWFGVGSPPELIQGIF-NVPSfahiNTDMTSLPEV 962
Cdd:PTZ00395 1412 ikgktneidSMDVDDDLfIPKTIPSSAEKIYSNGIYLLDACTHFYLYFGFHSDANFAKEIVgDIPT----EKNAHELNLT 1487

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46560565   963 GSPHSQQLRMIMNNIQQKKPYS--MKLIVVKQREQREMAFRQFLVEDKGlYGGSSYVDFLCCVHK 1025
Cdd:PTZ00395 1488 DTPNAQKVQRIIKNLSRIHHFNkyVPLVMVAPKSNEEEHLISLCVEDKA-DKEYSYVNFLCFIHK 1551
Sec23_helical pfam04815
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ...
 783-883 1.88e-34

Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.


Pssm-ID: 461441 [Multi-domain]  Cd Length: 103  Bit Score: 127.23  E-value: 1.88e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565    783 DALINFFAKSAFKAVLNQPLKAIREILVNQTAHMLACYRKHCASPSAASQLILPDSMKVLPVYMNSLLKNCVLLSRSEIS 862
Cdd:pfam04815    3 EAIAVLLAKKAVEKALSSSLSDAREALDNKLVDILAAYRKYCASSSSPGQLILPESLKLLPLYMLALLKSPALRGGNSSP 82

                           90       100
                   ....*....|....*....|.
gi 46560565    863 PDERAYQRQLVMTMGVADSQL 883
Cdd:pfam04815   83 SDERAYARHLLLSLPVEELLL 103
Sec23_BS pfam08033
Sec23/Sec24 beta-sandwich domain;
686-770 9.27e-30

Sec23/Sec24 beta-sandwich domain;


Pssm-ID: 429794 [Multi-domain]  Cd Length: 86  Bit Score: 113.02  E-value: 9.27e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565    686 GFDAIMRVRTSTGFRATDFFGGIFMNNTTD-VEMAAIDCDKAVTVEFKHDDKLSEDVGALIQCAVLYTTISGQRRLRIHN 764
Cdd:pfam08033    1 GFNAVLRVRTSKGLKVSGFIGNFVSRSSGDtWKLPSLDPDTSYAFEFDIDEPLPNGSNAYIQFALLYTHSSGERRIRVTT 80


                   ....*.
gi 46560565    765 LALNCS 770
Cdd:pfam08033   81 VALPVT 86
SEC23 COG5047
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
312-896 4.54e-22

Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];


Pssm-ID: 227380 [Multi-domain]  Cd Length: 755  Bit Score: 102.65  E-value: 4.54e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  312 IRCTTYCFPCTSDMAKQAQIPLAAVIKPFadippNETPLYLVNHGEsgPVRCNR-CKAYMCPFMQFIEGGRRYQCGFCSC 390
Cdd:COG5047   12 IRLTWNVFPATRGDATRTVIPIACLYTPL-----HEDDALTVNYYE--PVKCTApCKAVLNPYCHIDERNQSWICPFCNQ 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  391 VNEVPPFYfqhldhigRRLDHYEKPELSLGSYeyvATLDYCRKNKPPSPPAFIFMIDVSYSNIKNGLVKlicEELKTALK 470
Cdd:COG5047   85 RNTLPPQY--------RDISNANLPLELLPQS---STIEYTLSKPVILPPVFFFVVDACCDEEELTALK---DSLIVSLS 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  471 RLPKEeheetsAIrVGFITYNKVLHFFNV------KSNLAQP----QMMVVTDVGEVFVPLLDG---------------- 524
Cdd:COG5047  151 LLPPE------AL-VGLITYGTSIQVHELnaenhrRSYVFSGnkeyTKENLQELLALSKPTKSGgfeskisgigqfassr 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  525 FLVNYEESQSVIHNLLDQIPEmfaDSNENETVFAPVIQAGMeALKAA---------ECPGKLFIFHSSlPTAEAPGKLKN 595
Cdd:COG5047  224 FLLPTQQCEFKLLNILEQLQP---DPWPVPAGKRPLRCTGS-ALNIAsslleqcfpNAGCHIVLFAGG-PCTVGPGTVVS 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  596 RDDKK------LVNTDKEKiLFQPQTAVYESLAKDCVANSCSVTLFLfpSQFVDVASLGLVPLL--TGGTLYKYNVF--Q 665
Cdd:COG5047  299 TELKEpmrshhDIESDSAQ-HSKKATKFYKGLAERVANQGHALDIFA--GCLDQIGIMEMEPLTtsTGGALVLSDSFttS 375

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  666 IHSDSQRFLTDLRNDIEKKIGFDAIMRVRTSTGFRATDFFG---------------GIFMNNTTDVEMAAID--CDKAVT 728
Cdd:COG5047  376 IFKQSFQRIFNRDSEGYLKMGFNANMEVKTSKNLKIKGLIGhavsvkkkannisdsEIGIGATNSWKMASLSpkSNYALY 455

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  729 VEFKHDDKLSEDVG---ALIQCAVLYTTISGQRRLRIHNLALNCSTQLADL-YKSCETDALINFFAK-SAFKAVLNQPLK 803
Cdd:COG5047  456 FEIALGAASGSAQRpaeAYIQFITTYQHSSGTYRIRVTTVARMFTDGGLPKiNRSFDQEAAAVFMARiAAFKAETEDIID 535

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565  804 AIREI---LVNQTAHmLACYRKhcaspSAASQLILPDSMKVLPVYMNSLLKNcVLLSRSEISPDERAYQRQLVMTMGVAD 880
Cdd:COG5047  536 VFRWIdrnLIRLCQK-FADYRK-----DDPSSFRLDPNFTLYPQFMYHLRRS-PFLSVFNNSPDETAFYRHMLNNADVND 608

                        650
                 ....*....|....*.
gi 46560565  881 SQLFFYPLLLPIHTLD 896
Cdd:COG5047  609 SLIMIQPTLQSYSFEK 624
zf-Sec23_Sec24 pfam04810
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 360-396 2.27e-15

Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.


Pssm-ID: 461437 [Multi-domain]  Cd Length: 38  Bit Score: 70.55  E-value: 2.27e-15
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 46560565    360 PVRCNRCKAYMCPFMQFIEGGRRYQCGFCSCVNEVPP 396
Cdd:pfam04810    1 PVRCRRCRAYLNPFCQFDFGGKKWTCNFCGTRNPVPP 37
PLN00162 PLN00162
transport protein sec23; Provisional
 312-490 2.76e-10

transport protein sec23; Provisional


Pssm-ID: 215083 [Multi-domain]  Cd Length: 761  Bit Score: 64.58  E-value: 2.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565   312 IRCTTYCFPCTSDMAKQAQIPLAAVIKPFADIPPNETPLYlvnhgesGPVRCNRCKAYMCPFMQFIEGGRRYQCGFCSCV 391
Cdd:PLN00162   12 VRMSWNVWPSSKIEASKCVIPLAALYTPLKPLPELPVLPY-------DPLRCRTCRAVLNPYCRVDFQAKIWICPFCFQR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565   392 NEVPPFYFQhldhIGrrlDHYEKPELslgsYEYVATLDY---CRKNKPPSPPAFIFMIDVSysniknglvkLICEEL--- 465
Cdd:PLN00162   85 NHFPPHYSS----IS---ETNLPAEL----FPQYTTVEYtlpPGSGGAPSPPVFVFVVDTC----------MIEEELgal 143

                         170       180
                  ....*....|....*....|....*....
gi 46560565   466 KTALKR----LPkeeheETSaiRVGFITY 490
Cdd:PLN00162  144 KSALLQaialLP-----ENA--LVGLITF 165
Gelsolin pfam00626
Gelsolin repeat;
902-974 3.18e-10

Gelsolin repeat;


Pssm-ID: 395501 [Multi-domain]  Cd Length: 76  Bit Score: 57.32  E-value: 3.18e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46560565    902 LPPAVRCSESRLSEEGIFLLANGLNMFLWFGVGSppELIQGIFNVPSFAHINTDM-TSLPEVG-SPHSQQLRMIM 974
Cdd:pfam00626    4 LPPPVPLSQESLNSGDCYLLDNGFTIFLWVGKGS--SLLEKLFAALLAAQLDDDErFPLPEVIrVPQGKEPARFL 76
PHA03378 PHA03378
EBNA-3B; Provisional
 90-267 9.57e-06

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 49.68  E-value: 9.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565    90 SVAPSYASGQTL-PQ-SSYPGPGSTSS--------------VTQLGSQFSSMQINSYGVGATPQSQGPPgpqsagafQGP 153
Cdd:PHA03378  587 SSAPSYAQTPWPvPHpSQTPEPPTTQShipetsaprqwpmpLRPIPMRPLRMQPITFNVLVFPTPHQPP--------QVE 658

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565   154 PQPAQPSILQPGHQVPPPPPTALN-------------------GPGASPMSPPTHRQ--DGLPGPAPLNAQYQPPPPPGQ 212
Cdd:PHA03378  659 ITPYKPTWTQIGHIPYQPSPTGANtmlpiqwapgtmqppprapTPMRPPAAPPGRAQrpAAATGRARPPAAAPGRARPPA 738

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 46560565   213 TLGPGYPPQQATNYG---PQMGGAQMSYPGGFPGGPAQM----AGPAPQLQRKLDPDSIPSP 267
Cdd:PHA03378  739 AAPGRARPPAAAPGRarpPAAAPGRARPPAAAPGAPTPQpppqAPPAPQQRPRGAPTPQPPP 800
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 1-327 5.48e-04

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 43.84  E-value: 5.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565      1 MSQQGYVATP--PYSQSQPGMGISPPHYGHYGDPSHASSPP--GVMKPLGPSAAPSGMLPpgplppgppQFGPNGAHTPG 76
Cdd:pfam09606  162 SSGQPGSGTPnqMGPNGGPGQGQAGGMNGGQQGPMGGQMPPqmGVPGMPGPADAGAQMGQ---------QAQANGGMNPQ 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565     77 HPPQrfpgpppvnsvapsyASGQTLPQSSYPGPGSTSSvtQLGSQFSSMQINSYGVG-----ATPQSQGPPGPQSAGAFQ 151
Cdd:pfam09606  233 QMGG---------------APNQVAMQQQQPQQQGQQS--QLGMGINQMQQMPQGVGggagqGGPGQPMGPPGQQPGAMP 295

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565    152 GPPQPAQPSILQPGHQVPPPPPTALNGPGASPMSPPTHRQDGLPGPAPLNAQYQPPPPPGQTLGPGYPPQQATNygPQMG 231
Cdd:pfam09606  296 NVMSIGDQNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGNFGGLGANPMQRGQ--PGMM 373

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565    232 GAQMSYPGG--------------------FPGGPAQMAGPAPQLQRKLDPDSIPSPI-QVIENDRATRGGQVYT----TN 286
Cdd:pfam09606  374 SSPSPVPGQqvrqvtpnqfmrqspqpsvpSPQGPGSQPPQSHPGGMIPSPALIPSPSpQMSQQPAQQRTIGQDSpggsLN 453

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 46560565    287 TRGQVPplVTTECVIQDQGHSSPRYIRCTTYCFPCTSDMAK 327
Cdd:pfam09606  454 TPGQSA--VNSPLNPQEEQLYREKYRQLTKYIEPLKRMIAK 492
PHA03247 PHA03247
large tegument protein UL36; Provisional
 8-293 1.33e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565     8 ATPPYSQSQPGmgiSPPHYGHYGDP-------SHASSPPGVMKPLGPsAAPSGMLPPGPLPPGPPQFGPNGAHTPGHPPQ 80
Cdd:PHA03247 2699 ADPPPPPPTPE---PAPHALVSATPlppgpaaARQASPALPAAPAPP-AVPAGPATPGGPARPARPPTTAGPPAPAPPAA 2774

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565    81 RFPGPPPVNSVAPSYASGQTLPqsSYPGPGSTSSVTQLGSQFSSMQINSygvgATPQSQGPPGPQSAGAFQGPPQPAQPS 160
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRE--SLPSPWDPADPPAAVLAPAAALPPA----ASPAGPLPPPTSAQPTAPPPPPGPPPP 2848

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565   161 ILQPGHQVPPPPPTALNGPG----ASPMSPPTHRQDGLPGPAPLNAQYQPPPPPGQTLGPGyPPQQATNYGPQMGGAQMS 236
Cdd:PHA03247 2849 SLPLGGSVAPGGDVRRRPPSrspaAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPP-QPQAPPPPQPQPQPPPPP 2927

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 46560565   237 YPGGFPGGPAQmagPAPQLQRKLDPDSIPSPIQVIENDRATRGGQVYTTNTRGQVPP 293
Cdd:PHA03247 2928 QPQPPPPPPPR---PQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQ 2981
PHA03378 PHA03378
EBNA-3B; Provisional
 28-270 1.47e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.75  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565    28 HYGDPSHASSPPGVMKPLgPSAAPSGMLPPGPLPPGPPQFGPNGAHTPGHPPQRFPGPPPVNSVAPSYASGQtlpqssyP 107
Cdd:PHA03378  605 TPEPPTTQSHIPETSAPR-QWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQ-------P 676

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565   108 GPGSTSSVTQLGSQFSSMQINSYGVGATPQSQGPPGPQSAGafQGPPQPAQPSILQPGhqvPPPPPTALNGPGASPMSPP 187
Cdd:PHA03378  677 SPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRP--AAATGRARPPAAAPG---RARPPAAAPGRARPPAAAP 751

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565   188 T--HRQDGLPGPAPLNAQYQPPPPpgqtlgpgypPQQAtnygPQMGGAQMSYPGGfpggpaqmaGPAPQLQrkldPDSIP 265
Cdd:PHA03378  752 GraRPPAAAPGRARPPAAAPGAPT----------PQPP----PQAPPAPQQRPRG---------APTPQPP----PQAGP 804


                  ....*
gi 46560565   266 SPIQV 270
Cdd:PHA03378  805 TSMQL 809
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 3-271 2.28e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 2.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565      3 QQGYVATPPYSQSQPGMGI--SPPHYGHYGDPSHASSPPGVMKPLGPSAAPSGMLPPGPLPPG-------PPQFGPNGAH 73
Cdd:pfam03154  164 QQILQTQPPVLQAQSGAASppSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAphtliqqTPTLHPQRLP 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565     74 TPGHPPQRFPGPPPVNSVAPsyasgQTLPQSSYPGPGS-TSSVTQLGSQFSSMQINSYGVGATP---QSQGPPGPQSAGa 149
Cdd:pfam03154  244 SPHPPLQPMTQPPPPSQVSP-----QPLPQPSLHGQMPpMPHSLQTGPSHMQHPVPPQPFPLTPqssQSQVPPGPSPAA- 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565    150 fqgpPQPAQPSILQPGHQvppppptalngPGASPMSPPthRQDGLPgPAPLnaQYQPPPPPGQTLGPGYPPQQATNYGPQ 229
Cdd:pfam03154  318 ----PGQSQQRIHTPPSQ-----------SQLQSQQPP--REQPLP-PAPL--SMPHIKPPPTTPIPQLPNPQSHKHPPH 377

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 46560565    230 MGG-AQMSYPGGFPGGPAqmAGPAPQLQRKLDPDSIPSPIQVI 271
Cdd:pfam03154  378 LSGpSPFQMNSNLPPPPA--LKPLSSLSTHHPPSAHPPPLQLM 418
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 1-256 8.79e-03

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 39.99  E-value: 8.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565      1 MSQQGYVATPPYSQSQ--PGMGISPPHYGhygdpshaSSPPGvmkPLGPSAAPSGmlppgplppgppqfGPNGAHTPGHP 78
Cdd:pfam09606   72 MGGGQQGMPDPINALQnlAGQGTRPQMMG--------PMGPG---PGGPMGQQMG--------------GPGTASNLLAS 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565     79 PQRFPGPPPVNSVAPSYASGQTLPQSSYPGPGSTSSVTQLGSQFSSmQINSYGVGATPQSQGPPGPQsagafQGPPQPAQ 158
Cdd:pfam09606  127 LGRPQMPMGGAGFPSQMSRVGRMQPGGQAGGMMQPSSGQPGSGTPN-QMGPNGGPGQGQAGGMNGGQ-----QGPMGGQM 200

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46560565    159 PSilQPGHQvppppptalNGPGasPMSPPTHRQDGLPGPAPLNAQYQPPPppgqtlgpgyPPQQATNYGPQMGGAQMSYP 238
Cdd:pfam09606  201 PP--QMGVP---------GMPG--PADAGAQMGQQAQANGGMNPQQMGGA----------PNQVAMQQQQPQQQGQQSQL 257

                          250
                   ....*....|....*...
gi 46560565    239 GGFPGGPAQMAGPAPQLQ 256
Cdd:pfam09606  258 GMGINQMQQMPQGVGGGA 275
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH