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Conserved domains on  [gi|21312544|ref|NP_081596|]
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interferon-induced 35 kDa protein homolog [Mus musculus]

Protein Classification

IFP_35_N and NID domain-containing protein( domain architecture ID 10935432)

IFP_35_N and NID domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NID pfam07292
Nmi/IFP 35 domain (NID); This family represents a domain of approximately 90 residues that is ...
 81-171 7.95e-36

Nmi/IFP 35 domain (NID); This family represents a domain of approximately 90 residues that is tandemly repeated within interferon-induced 35 kDa protein (IFP 35) and the homologous N-myc-interactor (Nmi). This domain mediates Nmi-Nmi protein interactions and subcellular localization.


:

Pssm-ID: 462137  Cd Length: 90  Bit Score: 123.71  E-value: 7.95e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312544    81 ALVTFEDPKVVDRLLQQKEHRVNLEDCRLRVQVQPLELPVVTNIQVSSQPDNHRVLVSGFPAGLRlSEEELLDKLEIFFG 160
Cdd:pfam07292   1 ALITFEEEGVAQRILKKKKHPVPLEKSCVRVKVSPVTLGHLVKFQVFSGVSKRTVLLSGIPDVLE-DEEELQDKLEIHFQ 79

                          90
                  ....*....|.
gi 21312544   161 KAKNGGGDVET 171
Cdd:pfam07292  80 KPSNGGGEVES 90
NID pfam07292
Nmi/IFP 35 domain (NID); This family represents a domain of approximately 90 residues that is ...
 179-267 2.35e-35

Nmi/IFP 35 domain (NID); This family represents a domain of approximately 90 residues that is tandemly repeated within interferon-induced 35 kDa protein (IFP 35) and the homologous N-myc-interactor (Nmi). This domain mediates Nmi-Nmi protein interactions and subcellular localization.


:

Pssm-ID: 462137  Cd Length: 90  Bit Score: 122.17  E-value: 2.35e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312544   179 VMLGFADEEVAQHLCQIGQFRVPLDRQQVLLRVSPYVSGEIQKAEIKFQQAPHSVLVTNIPDVMDAQE-LHDILEIHFQK 257
Cdd:pfam07292   1 ALITFEEEGVAQRILKKKKHPVPLEKSCVRVKVSPVTLGHLVKFQVFSGVSKRTVLLSGIPDVLEDEEeLQDKLEIHFQK 80

                          90
                  ....*....|
gi 21312544   258 PTRGGGEVEA 267
Cdd:pfam07292  81 PSNGGGEVES 90
IFP_35_N super family cl06392
Interferon-induced 35 kDa protein (IFP 35) N-terminus; This family represents the N-terminus ...
 8-80 9.19e-14

Interferon-induced 35 kDa protein (IFP 35) N-terminus; This family represents the N-terminus of interferon-induced 35 kDa protein (IFP 35) (approximately 80 residues long), which contains a leucine zipper motif in an alpha helical configuration. This family also includes N-myc-interactor (Nmi), a homologous interferon-induced protein.


The actual alignment was detected with superfamily member pfam07334:

Pssm-ID: 284696  Cd Length: 76  Bit Score: 64.96  E-value: 9.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312544     8 VLYSLQEEQARLKMRLQ----ELQQLKRE---RTGSPGAKIPFSVPEVPlvfqGQTKQGRQVPKFVVSNLKVCCPLPEGS 80
Cdd:pfam07334   1 LIYEITKENIQLKEEIQkleaELQETTREfqiKEDIPETKIKFTSVETP----EDDSQFSNISCSFQVSSKIPYELQKGQ 76
 
Name Accession Description Interval E-value
NID pfam07292
Nmi/IFP 35 domain (NID); This family represents a domain of approximately 90 residues that is ...
 81-171 7.95e-36

Nmi/IFP 35 domain (NID); This family represents a domain of approximately 90 residues that is tandemly repeated within interferon-induced 35 kDa protein (IFP 35) and the homologous N-myc-interactor (Nmi). This domain mediates Nmi-Nmi protein interactions and subcellular localization.


Pssm-ID: 462137  Cd Length: 90  Bit Score: 123.71  E-value: 7.95e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312544    81 ALVTFEDPKVVDRLLQQKEHRVNLEDCRLRVQVQPLELPVVTNIQVSSQPDNHRVLVSGFPAGLRlSEEELLDKLEIFFG 160
Cdd:pfam07292   1 ALITFEEEGVAQRILKKKKHPVPLEKSCVRVKVSPVTLGHLVKFQVFSGVSKRTVLLSGIPDVLE-DEEELQDKLEIHFQ 79

                          90
                  ....*....|.
gi 21312544   161 KAKNGGGDVET 171
Cdd:pfam07292  80 KPSNGGGEVES 90
NID pfam07292
Nmi/IFP 35 domain (NID); This family represents a domain of approximately 90 residues that is ...
 179-267 2.35e-35

Nmi/IFP 35 domain (NID); This family represents a domain of approximately 90 residues that is tandemly repeated within interferon-induced 35 kDa protein (IFP 35) and the homologous N-myc-interactor (Nmi). This domain mediates Nmi-Nmi protein interactions and subcellular localization.


Pssm-ID: 462137  Cd Length: 90  Bit Score: 122.17  E-value: 2.35e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312544   179 VMLGFADEEVAQHLCQIGQFRVPLDRQQVLLRVSPYVSGEIQKAEIKFQQAPHSVLVTNIPDVMDAQE-LHDILEIHFQK 257
Cdd:pfam07292   1 ALITFEEEGVAQRILKKKKHPVPLEKSCVRVKVSPVTLGHLVKFQVFSGVSKRTVLLSGIPDVLEDEEeLQDKLEIHFQK 80

                          90
                  ....*....|
gi 21312544   258 PTRGGGEVEA 267
Cdd:pfam07292  81 PSNGGGEVES 90
RRM_IN35 cd12545
RNA recognition motif in interferon-induced 35 kDa protein (IFP 35) and similar proteins; This ...
 133-211 3.42e-30

RNA recognition motif in interferon-induced 35 kDa protein (IFP 35) and similar proteins; This subgroup corresponds to the RRM in IFP 35, an interferon-induced leucine zipper protein that can specifically form homodimers. Distinct from known bZIP proteins, IFP 35 lacks a basic domain critical for DNA binding. IFP 35 may negatively regulate other bZIP transcription factors by protein-protein interaction. For instance, it can form heterodimers with B-ATF, a member of the AP1 transcription factor family. IFP 35 contains one RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain).


Pssm-ID: 409961  Cd Length: 79  Bit Score: 108.70  E-value: 3.42e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312544 133 HRVLVSGFPAGLrlSEEELLDKLEIFFGKAKNGGGDVETREMLQ--GTVMLGFADEEVAQHLCQIGQFRVPLDRQQVLLR 210
Cdd:cd12545   1 RRILVSNLPIEE--PEERILDKLEIFFGKTRNGGGEVDEREFLDdcGSVVLTFVEDGVAKRLTDKGQFEVPFGKRKYKVK 78


                .
gi 21312544 211 V 211
Cdd:cd12545  79 V 79
IFP_35_N pfam07334
Interferon-induced 35 kDa protein (IFP 35) N-terminus; This family represents the N-terminus ...
 8-80 9.19e-14

Interferon-induced 35 kDa protein (IFP 35) N-terminus; This family represents the N-terminus of interferon-induced 35 kDa protein (IFP 35) (approximately 80 residues long), which contains a leucine zipper motif in an alpha helical configuration. This family also includes N-myc-interactor (Nmi), a homologous interferon-induced protein.


Pssm-ID: 284696  Cd Length: 76  Bit Score: 64.96  E-value: 9.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312544     8 VLYSLQEEQARLKMRLQ----ELQQLKRE---RTGSPGAKIPFSVPEVPlvfqGQTKQGRQVPKFVVSNLKVCCPLPEGS 80
Cdd:pfam07334   1 LIYEITKENIQLKEEIQkleaELQETTREfqiKEDIPETKIKFTSVETP----EDDSQFSNISCSFQVSSKIPYELQKGQ 76
RRM_NMI cd12544
RNA recognition motif in N-myc-interactor (Nmi) and similar proteins; This subgroup ...
 235-283 3.67e-07

RNA recognition motif in N-myc-interactor (Nmi) and similar proteins; This subgroup corresponds to the RRM.in Nmi, also termed N-myc and STAT interactor, an interferon inducible protein that interacts with c-Myc, N-Myc, Max and c-Fos, and other transcription factors containing bHLH-ZIP, bHLH or ZIP domains. In addition to binding Myc proteins, Nmi also associates with all the Stat family of transcription factors except Stat2. In response to cytokines (e.g. IL-2 and IFN-gamma) stimulation, Nmi can enhance Stat-mediated transcriptional activity through recruiting the Stat1 and Stat5 transcriptional coactivators, CREB-binding protein (CBP) and p300. Nmi contains one RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain).


Pssm-ID: 409960  Cd Length: 81  Bit Score: 47.02  E-value: 3.67e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 21312544 235 VTNIPDVMDAQELHDILEIHFQKPTRGGGEVEALTVVPSGQQGLAIFTS 283
Cdd:cd12544   5 VSNIPDPLPDERMRDKLELSFSKPSRGGGEVEDVHYDRESGTAVITFLE 53
 
Name Accession Description Interval E-value
NID pfam07292
Nmi/IFP 35 domain (NID); This family represents a domain of approximately 90 residues that is ...
 81-171 7.95e-36

Nmi/IFP 35 domain (NID); This family represents a domain of approximately 90 residues that is tandemly repeated within interferon-induced 35 kDa protein (IFP 35) and the homologous N-myc-interactor (Nmi). This domain mediates Nmi-Nmi protein interactions and subcellular localization.


Pssm-ID: 462137  Cd Length: 90  Bit Score: 123.71  E-value: 7.95e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312544    81 ALVTFEDPKVVDRLLQQKEHRVNLEDCRLRVQVQPLELPVVTNIQVSSQPDNHRVLVSGFPAGLRlSEEELLDKLEIFFG 160
Cdd:pfam07292   1 ALITFEEEGVAQRILKKKKHPVPLEKSCVRVKVSPVTLGHLVKFQVFSGVSKRTVLLSGIPDVLE-DEEELQDKLEIHFQ 79

                          90
                  ....*....|.
gi 21312544   161 KAKNGGGDVET 171
Cdd:pfam07292  80 KPSNGGGEVES 90
NID pfam07292
Nmi/IFP 35 domain (NID); This family represents a domain of approximately 90 residues that is ...
 179-267 2.35e-35

Nmi/IFP 35 domain (NID); This family represents a domain of approximately 90 residues that is tandemly repeated within interferon-induced 35 kDa protein (IFP 35) and the homologous N-myc-interactor (Nmi). This domain mediates Nmi-Nmi protein interactions and subcellular localization.


Pssm-ID: 462137  Cd Length: 90  Bit Score: 122.17  E-value: 2.35e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312544   179 VMLGFADEEVAQHLCQIGQFRVPLDRQQVLLRVSPYVSGEIQKAEIKFQQAPHSVLVTNIPDVMDAQE-LHDILEIHFQK 257
Cdd:pfam07292   1 ALITFEEEGVAQRILKKKKHPVPLEKSCVRVKVSPVTLGHLVKFQVFSGVSKRTVLLSGIPDVLEDEEeLQDKLEIHFQK 80

                          90
                  ....*....|
gi 21312544   258 PTRGGGEVEA 267
Cdd:pfam07292  81 PSNGGGEVES 90
RRM_IN35 cd12545
RNA recognition motif in interferon-induced 35 kDa protein (IFP 35) and similar proteins; This ...
 133-211 3.42e-30

RNA recognition motif in interferon-induced 35 kDa protein (IFP 35) and similar proteins; This subgroup corresponds to the RRM in IFP 35, an interferon-induced leucine zipper protein that can specifically form homodimers. Distinct from known bZIP proteins, IFP 35 lacks a basic domain critical for DNA binding. IFP 35 may negatively regulate other bZIP transcription factors by protein-protein interaction. For instance, it can form heterodimers with B-ATF, a member of the AP1 transcription factor family. IFP 35 contains one RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain).


Pssm-ID: 409961  Cd Length: 79  Bit Score: 108.70  E-value: 3.42e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312544 133 HRVLVSGFPAGLrlSEEELLDKLEIFFGKAKNGGGDVETREMLQ--GTVMLGFADEEVAQHLCQIGQFRVPLDRQQVLLR 210
Cdd:cd12545   1 RRILVSNLPIEE--PEERILDKLEIFFGKTRNGGGEVDEREFLDdcGSVVLTFVEDGVAKRLTDKGQFEVPFGKRKYKVK 78


                .
gi 21312544 211 V 211
Cdd:cd12545  79 V 79
IFP_35_N pfam07334
Interferon-induced 35 kDa protein (IFP 35) N-terminus; This family represents the N-terminus ...
 8-80 9.19e-14

Interferon-induced 35 kDa protein (IFP 35) N-terminus; This family represents the N-terminus of interferon-induced 35 kDa protein (IFP 35) (approximately 80 residues long), which contains a leucine zipper motif in an alpha helical configuration. This family also includes N-myc-interactor (Nmi), a homologous interferon-induced protein.


Pssm-ID: 284696  Cd Length: 76  Bit Score: 64.96  E-value: 9.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312544     8 VLYSLQEEQARLKMRLQ----ELQQLKRE---RTGSPGAKIPFSVPEVPlvfqGQTKQGRQVPKFVVSNLKVCCPLPEGS 80
Cdd:pfam07334   1 LIYEITKENIQLKEEIQkleaELQETTREfqiKEDIPETKIKFTSVETP----EDDSQFSNISCSFQVSSKIPYELQKGQ 76
RRM1_2_PAR10_like cd12301
RNA recognition motif 1 and 2 in poly [ADP-ribose] polymerase PARP-10, RNA recognition motif 2 ...
 134-211 1.15e-12

RNA recognition motif 1 and 2 in poly [ADP-ribose] polymerase PARP-10, RNA recognition motif 2 in PARP-14, RNA recognition motif in N-myc-interactor (Nmi), interferon-induced 35 kDa protein (IFP 35), RNA-binding protein 43 (RBM43) and similar proteins; This subfamily corresponds to the RRM1 and RRM2 of PARP-10, RRM2 of PARP-14, RRM of N-myc-interactor (Nmi), interferon-induced 35 kDa protein (IFP 35) and RNA-binding protein 43 (RBM43). PARP-10 is a novel oncoprotein c-Myc-interacting protein with poly(ADP-ribose) polymerase activity. It is localized to the nuclear and cytoplasmic compartments. In addition to PARP activity, PARP-10 is also involved in the control of cell proliferation by inhibiting c-Myc- and E1A-mediated cotransformation of primary cells. PARP-10 may also play a role in nuclear processes including the regulation of chromatin, gene transcription, and nuclear/cytoplasmic transport. PARP-10 contains two N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), two overlapping C-terminal domains composed of a glycine-rich region and a region with homology to catalytic domains of PARP enzymes (PARP domain). In addition, PARP-10 contains two ubiquitin-interacting motifs (UIM). PARP-14, also termed aggressive lymphoma protein 2, is a member of the B aggressive lymphoma (BAL) family of macrodomain-containing PARPs. Like PARP-10, PARP-14 also includes two RRMs at the N-terminus. Nmi, also termed N-myc and STAT interactor, is an interferon inducible protein that interacts with c-Myc, N-Myc, Max and c-Fos, and other transcription factors containing bHLH-ZIP, bHLH or ZIP domains. Besides binding Myc proteins, Nmi also associates with all the Stat family of transcription factors except Stat2. In response to cytokine (e.g. IL-2 and IFN-gamma) stimulation, Nmi can enhance Stat-mediated transcriptional activity through recruiting the Stat1 and Stat5 transcriptional coactivators, CREB-binding protein (CBP) and p300. IFP 35 is an interferon-induced leucine zipper protein that can specifically form homodimers. Distinct from known bZIP proteins, IFP 35 lacks a basic domain critical for DNA binding. In addition, IFP 35 may negatively regulate other bZIP transcription factors by protein-protein interaction. For instance, it can form heterodimers with B-ATF, a member of the AP1 transcription factor family. Both Nmi and IFP35 harbor one RRM. RBM43 is a putative RNA-binding protein containing one RRM, but its biological function remains unclear.


Pssm-ID: 409742 [Multi-domain]  Cd Length: 74  Bit Score: 61.97  E-value: 1.15e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312544 134 RVLVSGFPAGlrlseEELLDKLEIFFGKAKNGGGDVETREML--QGTVMLGFADEEVAQHLCQIGQfrVPLDRQQVLLRV 211
Cdd:cd12301   2 SVLVTGLPEA-----EALDDKLELYFENSRSGGGDVEDVEYLgeKGSAVVTFKDHKVAQRVLAQKK--HPLNGMQLSVRP 74
RRM_RBM43 cd12546
RNA recognition motif in vertebrate RNA-binding protein 43 (RBM43); This subgroup corresponds ...
 135-215 9.09e-10

RNA recognition motif in vertebrate RNA-binding protein 43 (RBM43); This subgroup corresponds to the RRM of RBM43, a putative RNA-binding protein containing one RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain). Although its biological function remains unclear, RBM43 shows high sequence homology to poly [ADP-ribose] polymerase 10 (PARP-10), which is a novel oncoprotein c-Myc-interacting protein with poly(ADP-ribose) polymerase activity.


Pssm-ID: 409962 [Multi-domain]  Cd Length: 77  Bit Score: 53.97  E-value: 9.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312544 135 VLVSGFPAGLRlsEEELLDKLEIFFGKAKNGGGDVET---REMLQGTVMLGFADEEVAQHLcqigqfrvpLDRQQVLLRV 211
Cdd:cd12546   3 IVVSGLPDDLF--EGALKDKLEIHFQRRKNGGGDVETvtyPTNTKGVAYVTFEEEEVAQNV---------LEKEQVLEDK 71


                ....
gi 21312544 212 SPYV 215
Cdd:cd12546  72 VLEV 75
RRM_NMI cd12544
RNA recognition motif in N-myc-interactor (Nmi) and similar proteins; This subgroup ...
 235-283 3.67e-07

RNA recognition motif in N-myc-interactor (Nmi) and similar proteins; This subgroup corresponds to the RRM.in Nmi, also termed N-myc and STAT interactor, an interferon inducible protein that interacts with c-Myc, N-Myc, Max and c-Fos, and other transcription factors containing bHLH-ZIP, bHLH or ZIP domains. In addition to binding Myc proteins, Nmi also associates with all the Stat family of transcription factors except Stat2. In response to cytokines (e.g. IL-2 and IFN-gamma) stimulation, Nmi can enhance Stat-mediated transcriptional activity through recruiting the Stat1 and Stat5 transcriptional coactivators, CREB-binding protein (CBP) and p300. Nmi contains one RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain).


Pssm-ID: 409960  Cd Length: 81  Bit Score: 47.02  E-value: 3.67e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 21312544 235 VTNIPDVMDAQELHDILEIHFQKPTRGGGEVEALTVVPSGQQGLAIFTS 283
Cdd:cd12544   5 VSNIPDPLPDERMRDKLELSFSKPSRGGGEVEDVHYDRESGTAVITFLE 53
RRM_RBM43 cd12546
RNA recognition motif in vertebrate RNA-binding protein 43 (RBM43); This subgroup corresponds ...
 232-285 4.83e-07

RNA recognition motif in vertebrate RNA-binding protein 43 (RBM43); This subgroup corresponds to the RRM of RBM43, a putative RNA-binding protein containing one RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain). Although its biological function remains unclear, RBM43 shows high sequence homology to poly [ADP-ribose] polymerase 10 (PARP-10), which is a novel oncoprotein c-Myc-interacting protein with poly(ADP-ribose) polymerase activity.


Pssm-ID: 409962 [Multi-domain]  Cd Length: 77  Bit Score: 46.65  E-value: 4.83e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 21312544 232 SVLVTNIPDVMDAQELHDILEIHFQKPTRGGGEVEALTvVPSGQQGLAIFTSES 285
Cdd:cd12546   2 TIVVSGLPDDLFEGALKDKLEIHFQRRKNGGGDVETVT-YPTNTKGVAYVTFEE 54
RRM_IN35 cd12545
RNA recognition motif in interferon-induced 35 kDa protein (IFP 35) and similar proteins; This ...
 231-282 1.61e-05

RNA recognition motif in interferon-induced 35 kDa protein (IFP 35) and similar proteins; This subgroup corresponds to the RRM in IFP 35, an interferon-induced leucine zipper protein that can specifically form homodimers. Distinct from known bZIP proteins, IFP 35 lacks a basic domain critical for DNA binding. IFP 35 may negatively regulate other bZIP transcription factors by protein-protein interaction. For instance, it can form heterodimers with B-ATF, a member of the AP1 transcription factor family. IFP 35 contains one RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain).


Pssm-ID: 409961  Cd Length: 79  Bit Score: 42.45  E-value: 1.61e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 21312544 231 HSVLVTNIPDVMDAQELHDILEIHFQKPTRGGGEVEALTVVPSGQQGLAIFT 282
Cdd:cd12545   1 RRILVSNLPIEEPEERILDKLEIFFGKTRNGGGEVDEREFLDDCGSVVLTFV 52
RRM_NMI cd12544
RNA recognition motif in N-myc-interactor (Nmi) and similar proteins; This subgroup ...
 134-192 2.16e-04

RNA recognition motif in N-myc-interactor (Nmi) and similar proteins; This subgroup corresponds to the RRM.in Nmi, also termed N-myc and STAT interactor, an interferon inducible protein that interacts with c-Myc, N-Myc, Max and c-Fos, and other transcription factors containing bHLH-ZIP, bHLH or ZIP domains. In addition to binding Myc proteins, Nmi also associates with all the Stat family of transcription factors except Stat2. In response to cytokines (e.g. IL-2 and IFN-gamma) stimulation, Nmi can enhance Stat-mediated transcriptional activity through recruiting the Stat1 and Stat5 transcriptional coactivators, CREB-binding protein (CBP) and p300. Nmi contains one RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain).


Pssm-ID: 409960  Cd Length: 81  Bit Score: 39.32  E-value: 2.16e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21312544 134 RVLVSGFPAglRLSEEELLDKLEIFFGKAKNGGGDVE--TREMLQGTVMLGFADEEVAQHL 192
Cdd:cd12544   2 KINVSNIPD--PLPDERMRDKLELSFSKPSRGGGEVEdvHYDRESGTAVITFLESGVAERI 60
RRM1_2_PAR10_like cd12301
RNA recognition motif 1 and 2 in poly [ADP-ribose] polymerase PARP-10, RNA recognition motif 2 ...
 232-281 3.69e-04

RNA recognition motif 1 and 2 in poly [ADP-ribose] polymerase PARP-10, RNA recognition motif 2 in PARP-14, RNA recognition motif in N-myc-interactor (Nmi), interferon-induced 35 kDa protein (IFP 35), RNA-binding protein 43 (RBM43) and similar proteins; This subfamily corresponds to the RRM1 and RRM2 of PARP-10, RRM2 of PARP-14, RRM of N-myc-interactor (Nmi), interferon-induced 35 kDa protein (IFP 35) and RNA-binding protein 43 (RBM43). PARP-10 is a novel oncoprotein c-Myc-interacting protein with poly(ADP-ribose) polymerase activity. It is localized to the nuclear and cytoplasmic compartments. In addition to PARP activity, PARP-10 is also involved in the control of cell proliferation by inhibiting c-Myc- and E1A-mediated cotransformation of primary cells. PARP-10 may also play a role in nuclear processes including the regulation of chromatin, gene transcription, and nuclear/cytoplasmic transport. PARP-10 contains two N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), two overlapping C-terminal domains composed of a glycine-rich region and a region with homology to catalytic domains of PARP enzymes (PARP domain). In addition, PARP-10 contains two ubiquitin-interacting motifs (UIM). PARP-14, also termed aggressive lymphoma protein 2, is a member of the B aggressive lymphoma (BAL) family of macrodomain-containing PARPs. Like PARP-10, PARP-14 also includes two RRMs at the N-terminus. Nmi, also termed N-myc and STAT interactor, is an interferon inducible protein that interacts with c-Myc, N-Myc, Max and c-Fos, and other transcription factors containing bHLH-ZIP, bHLH or ZIP domains. Besides binding Myc proteins, Nmi also associates with all the Stat family of transcription factors except Stat2. In response to cytokine (e.g. IL-2 and IFN-gamma) stimulation, Nmi can enhance Stat-mediated transcriptional activity through recruiting the Stat1 and Stat5 transcriptional coactivators, CREB-binding protein (CBP) and p300. IFP 35 is an interferon-induced leucine zipper protein that can specifically form homodimers. Distinct from known bZIP proteins, IFP 35 lacks a basic domain critical for DNA binding. In addition, IFP 35 may negatively regulate other bZIP transcription factors by protein-protein interaction. For instance, it can form heterodimers with B-ATF, a member of the AP1 transcription factor family. Both Nmi and IFP35 harbor one RRM. RBM43 is a putative RNA-binding protein containing one RRM, but its biological function remains unclear.


Pssm-ID: 409742 [Multi-domain]  Cd Length: 74  Bit Score: 38.47  E-value: 3.69e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 21312544 232 SVLVTNIPDvmdAQELHDILEIHFQKPTRGGGEVEALTVVPSGQQGLAIF 281
Cdd:cd12301   2 SVLVTGLPE---AEALDDKLELYFENSRSGGGDVEDVEYLGEKGSAVVTF 48
RRM1_2_PAR10_like cd12301
RNA recognition motif 1 and 2 in poly [ADP-ribose] polymerase PARP-10, RNA recognition motif 2 ...
 75-100 7.05e-04

RNA recognition motif 1 and 2 in poly [ADP-ribose] polymerase PARP-10, RNA recognition motif 2 in PARP-14, RNA recognition motif in N-myc-interactor (Nmi), interferon-induced 35 kDa protein (IFP 35), RNA-binding protein 43 (RBM43) and similar proteins; This subfamily corresponds to the RRM1 and RRM2 of PARP-10, RRM2 of PARP-14, RRM of N-myc-interactor (Nmi), interferon-induced 35 kDa protein (IFP 35) and RNA-binding protein 43 (RBM43). PARP-10 is a novel oncoprotein c-Myc-interacting protein with poly(ADP-ribose) polymerase activity. It is localized to the nuclear and cytoplasmic compartments. In addition to PARP activity, PARP-10 is also involved in the control of cell proliferation by inhibiting c-Myc- and E1A-mediated cotransformation of primary cells. PARP-10 may also play a role in nuclear processes including the regulation of chromatin, gene transcription, and nuclear/cytoplasmic transport. PARP-10 contains two N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), two overlapping C-terminal domains composed of a glycine-rich region and a region with homology to catalytic domains of PARP enzymes (PARP domain). In addition, PARP-10 contains two ubiquitin-interacting motifs (UIM). PARP-14, also termed aggressive lymphoma protein 2, is a member of the B aggressive lymphoma (BAL) family of macrodomain-containing PARPs. Like PARP-10, PARP-14 also includes two RRMs at the N-terminus. Nmi, also termed N-myc and STAT interactor, is an interferon inducible protein that interacts with c-Myc, N-Myc, Max and c-Fos, and other transcription factors containing bHLH-ZIP, bHLH or ZIP domains. Besides binding Myc proteins, Nmi also associates with all the Stat family of transcription factors except Stat2. In response to cytokine (e.g. IL-2 and IFN-gamma) stimulation, Nmi can enhance Stat-mediated transcriptional activity through recruiting the Stat1 and Stat5 transcriptional coactivators, CREB-binding protein (CBP) and p300. IFP 35 is an interferon-induced leucine zipper protein that can specifically form homodimers. Distinct from known bZIP proteins, IFP 35 lacks a basic domain critical for DNA binding. In addition, IFP 35 may negatively regulate other bZIP transcription factors by protein-protein interaction. For instance, it can form heterodimers with B-ATF, a member of the AP1 transcription factor family. Both Nmi and IFP35 harbor one RRM. RBM43 is a putative RNA-binding protein containing one RRM, but its biological function remains unclear.


Pssm-ID: 409742 [Multi-domain]  Cd Length: 74  Bit Score: 37.32  E-value: 7.05e-04
                        10        20
                ....*....|....*....|....*.
gi 21312544  75 PLPEGSALVTFEDPKVVDRLLQQKEH 100
Cdd:cd12301  38 LGEKGSAVVTFKDHKVAQRVLAQKKH 63
RRM2_hnRNPA3 cd12582
RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) ...
 79-110 3.86e-03

RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins; This subgroup corresponds to the RRM2 of hnRNP A3, a novel RNA trafficking response element-binding protein that interacts with the hnRNP A2 response element (A2RE) independently of hnRNP A2 and participates in the trafficking of A2RE-containing RNA. hnRNP A3 can shuttle between the nucleus and the cytoplasm. It contains two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), followed by a long glycine-rich region at the C-terminus.


Pssm-ID: 409996 [Multi-domain]  Cd Length: 80  Bit Score: 35.70  E-value: 3.86e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 21312544  79 GSALVTFEDPKVVDRLLQQKEHRVNLEDCRLR 110
Cdd:cd12582  43 GFAFVTFDDHDTVDKIVVQKYHTINGHNCEVK 74
RRM2_hnRNPA1 cd12580
RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) ...
 79-110 8.25e-03

RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins; This subgroup corresponds to the RRM2 of hnRNP A1, also termed helix-destabilizing protein, or single-strand RNA-binding protein, or hnRNP core protein A1, an abundant eukaryotic nuclear RNA-binding protein that may modulate splice site selection in pre-mRNA splicing. hnRNP A1 has been characterized as a splicing silencer, often acting in opposition to an activating hnRNP H. It silences exons when bound to exonic elements in the alternatively spliced transcripts of c-src, HIV, GRIN1, and beta-tropomyosin. hnRNP A1 can shuttle between the nucleus and the cytoplasm. Thus, it may be involved in transport of cellular RNAs, including the packaging of pre-mRNA into hnRNP particles and transport of poly A+ mRNA from the nucleus to the cytoplasm. The cytoplasmic hnRNP A1 has high affinity with AU-rich elements, whereas the nuclear hnRNP A1 has high affinity with a polypyrimidine stretch bordered by AG at the 3' ends of introns. hnRNP A1 is also involved in the replication of an RNA virus, such as mouse hepatitis virus (MHV), through an interaction with the transcription-regulatory region of viral RNA. Moreover, hnRNP A1, together with the scaffold protein septin 6, serves as host proteins to form a complex with NS5b and viral RNA, and further play important roles in the replication of Hepatitis C virus (HCV). hnRNP A1 contains two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), followed by a long glycine-rich region at the C-terminus. The RRMs of hnRNP A1 play an important role in silencing the exon and the glycine-rich domain is responsible for protein-protein interactions.


Pssm-ID: 409994 [Multi-domain]  Cd Length: 77  Bit Score: 34.56  E-value: 8.25e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 21312544  79 GSALVTFEDPKVVDRLLQQKEHRVNLEDCRLR 110
Cdd:cd12580  43 GFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVR 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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