NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|226443057|ref|NP_081665|]
View 

GON-4-like protein isoform 2 [Mus musculus]

Protein Classification

PAH and CASP8AP2 domain-containing protein( domain architecture ID 10496266)

PAH and CASP8AP2 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CASP8AP2 cd12202
Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of ...
 2144-2209 2.27e-35

Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of Caspase 8-associated protein 2 (CASP8AP2) / GON-4 like proteins. CASP8AP2 (aka Flice-Associated Huge Protein (FLASH)) is implicated in numerous gene regulatory roles including roles in embryogenesis, oncogenesis, down-regulation of replication-dependent histone genes, regulation of Caspase 8 activity at the death-inducing signaling complex (DISC), and as a useful marker in leukemia prognosis. Gon-4 is critical in Caenorhabditis elegans gonadogenesis. Danio rerio GON4 is a regulator of gene expression in hematopoietic development, possibly by repressing expression. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


:

Pssm-ID: 213401  Cd Length: 66  Bit Score: 129.41  E-value: 2.27e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226443057 2144 NSKVSSTGEKVVLWTREADRVILTMCQEQGAQPHTFSVISQQLGNKTPVEVSHRFRELMQLFHTAC 2209
Cdd:cd12202     1 NNVIKSKGEKVVLWTRDADRVILTACQEKGASPKTFAALASKLGKKTPQEVSERFRQLMKLFHKSC 66
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 1654-1699 5.94e-07

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


:

Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 47.80  E-value: 5.94e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 226443057  1654 KYEDFLQIIYEFesSTQMHSAVDLFKSLQTLLQDWPQLLKDFAAFL 1699
Cdd:pfam02671    2 VYDEFLKILNDY--KQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 974-1240 2.50e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 2.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443057  974 PGSKRFSRKAWRQKRPL-----VQKPLLIQPSPSVQPVFNPGKMATWPTQSEVPPSNTVVQIPHLIQPAAVLQTLPGFPS 1048
Cdd:PHA03247 2658 PGRVSRPRRARRLGRAAqasspPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPA 2737

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443057 1049 VGV--------------------RGEDGFESPTAlPAMPCGSEARTTFPLSETQSAPPSCSAPKLMLPSLAPSKFRKPYV 1108
Cdd:PHA03247 2738 APAppavpagpatpggparparpPTTAGPPAPAP-PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAA 2816

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443057 1109 RRKPTRRKGAKVSPCVKPAPIIHPTPVIFTVPATTVKVVSIGGGCNMIQPVSAAVAPSPQTipittllvnPTTFPCS-LN 1187
Cdd:PHA03247 2817 ALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAA---------PARPPVRrLA 2887

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 226443057 1188 QPLVASSISPLIVSSNPLT------LPVTSIPEDKAQVKLDVAEGKNAPQNPESKLKPQ 1240
Cdd:PHA03247 2888 RPAVSRSTESFALPPDQPErppqpqAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPT 2946
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 1754-1780 6.59e-04

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


:

Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 39.33  E-value: 6.59e-04
                           10        20
                   ....*....|....*....|....*..
gi 226443057  1754 DIAELKTQMWQLLRGHDHLQDEFSIFF 1780
Cdd:pfam02671   19 DIAEVIARVSELLKGHPDLLEGFNTFL 45
 
Name Accession Description Interval E-value
CASP8AP2 cd12202
Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of ...
 2144-2209 2.27e-35

Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of Caspase 8-associated protein 2 (CASP8AP2) / GON-4 like proteins. CASP8AP2 (aka Flice-Associated Huge Protein (FLASH)) is implicated in numerous gene regulatory roles including roles in embryogenesis, oncogenesis, down-regulation of replication-dependent histone genes, regulation of Caspase 8 activity at the death-inducing signaling complex (DISC), and as a useful marker in leukemia prognosis. Gon-4 is critical in Caenorhabditis elegans gonadogenesis. Danio rerio GON4 is a regulator of gene expression in hematopoietic development, possibly by repressing expression. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 213401  Cd Length: 66  Bit Score: 129.41  E-value: 2.27e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226443057 2144 NSKVSSTGEKVVLWTREADRVILTMCQEQGAQPHTFSVISQQLGNKTPVEVSHRFRELMQLFHTAC 2209
Cdd:cd12202     1 NNVIKSKGEKVVLWTRDADRVILTACQEKGASPKTFAALASKLGKKTPQEVSERFRQLMKLFHKSC 66
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 1654-1699 5.94e-07

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 47.80  E-value: 5.94e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 226443057  1654 KYEDFLQIIYEFesSTQMHSAVDLFKSLQTLLQDWPQLLKDFAAFL 1699
Cdd:pfam02671    2 VYDEFLKILNDY--KQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
PHA03247 PHA03247
large tegument protein UL36; Provisional
 974-1240 2.50e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 2.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443057  974 PGSKRFSRKAWRQKRPL-----VQKPLLIQPSPSVQPVFNPGKMATWPTQSEVPPSNTVVQIPHLIQPAAVLQTLPGFPS 1048
Cdd:PHA03247 2658 PGRVSRPRRARRLGRAAqasspPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPA 2737

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443057 1049 VGV--------------------RGEDGFESPTAlPAMPCGSEARTTFPLSETQSAPPSCSAPKLMLPSLAPSKFRKPYV 1108
Cdd:PHA03247 2738 APAppavpagpatpggparparpPTTAGPPAPAP-PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAA 2816

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443057 1109 RRKPTRRKGAKVSPCVKPAPIIHPTPVIFTVPATTVKVVSIGGGCNMIQPVSAAVAPSPQTipittllvnPTTFPCS-LN 1187
Cdd:PHA03247 2817 ALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAA---------PARPPVRrLA 2887

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 226443057 1188 QPLVASSISPLIVSSNPLT------LPVTSIPEDKAQVKLDVAEGKNAPQNPESKLKPQ 1240
Cdd:PHA03247 2888 RPAVSRSTESFALPPDQPErppqpqAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPT 2946
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 1754-1780 6.59e-04

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 39.33  E-value: 6.59e-04
                           10        20
                   ....*....|....*....|....*..
gi 226443057  1754 DIAELKTQMWQLLRGHDHLQDEFSIFF 1780
Cdd:pfam02671   19 DIAEVIARVSELLKGHPDLLEGFNTFL 45
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 986-1285 9.69e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.37  E-value: 9.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443057   986 QKRPLVQKPLLIQPSPSVQPVFNPGKMATWPTQSEVPPS--NTVVQIPHLIQ--PAAVLQTLP--GFPSVGVRGEdGFES 1059
Cdd:pfam03154  232 QQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhGQMPPMPHSLQtgPSHMQHPVPpqPFPLTPQSSQ-SQVP 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443057  1060 PTALPAMPCGSEARTTFPLSetQSAPPSCSAPKLMlpSLAPSKFRKPYVRRKPTrrkgAKVSPCVKPAPIIHPTPVIFTV 1139
Cdd:pfam03154  311 PGPSPAAPGQSQQRIHTPPS--QSQLQSQQPPREQ--PLPPAPLSMPHIKPPPT----TPIPQLPNPQSHKHPPHLSGPS 382

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443057  1140 PATtvkvvsigggcnmiqpVSAAVAPSPQTIPITTLLVN--PTTFPCSL-----NQPLVASSISPLIVSSNPlTLPVTSI 1212
Cdd:pfam03154  383 PFQ----------------MNSNLPPPPALKPLSSLSTHhpPSAHPPPLqlmpqSQQLPPPPAQPPVLTQSQ-SLPPPAA 445

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226443057  1213 PEDKAQVKLDVAEGKNAPQNPESKLKPQELTPLCTtvfskeePKSWHSSADTGSQEAFSESSACSWAVVKTES 1285
Cdd:pfam03154  446 SHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSG-------PPTSTSSAMPGIQPPSSASVSSSGPVPAAVS 511
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
2157-2201 7.58e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 36.43  E-value: 7.58e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 226443057   2157 WTREADRVILTMCQEQGaqPHTFSVISQQLGNKTPVEVSHRFREL 2201
Cdd:smart00717    4 WTEEEDELLIELVKKYG--KNNWEKIAKELPGRTAEQCRERWRNL 46
 
Name Accession Description Interval E-value
CASP8AP2 cd12202
Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of ...
 2144-2209 2.27e-35

Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of Caspase 8-associated protein 2 (CASP8AP2) / GON-4 like proteins. CASP8AP2 (aka Flice-Associated Huge Protein (FLASH)) is implicated in numerous gene regulatory roles including roles in embryogenesis, oncogenesis, down-regulation of replication-dependent histone genes, regulation of Caspase 8 activity at the death-inducing signaling complex (DISC), and as a useful marker in leukemia prognosis. Gon-4 is critical in Caenorhabditis elegans gonadogenesis. Danio rerio GON4 is a regulator of gene expression in hematopoietic development, possibly by repressing expression. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 213401  Cd Length: 66  Bit Score: 129.41  E-value: 2.27e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226443057 2144 NSKVSSTGEKVVLWTREADRVILTMCQEQGAQPHTFSVISQQLGNKTPVEVSHRFRELMQLFHTAC 2209
Cdd:cd12202     1 NNVIKSKGEKVVLWTRDADRVILTACQEKGASPKTFAALASKLGKKTPQEVSERFRQLMKLFHKSC 66
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 1654-1699 5.94e-07

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 47.80  E-value: 5.94e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 226443057  1654 KYEDFLQIIYEFesSTQMHSAVDLFKSLQTLLQDWPQLLKDFAAFL 1699
Cdd:pfam02671    2 VYDEFLKILNDY--KQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
PHA03247 PHA03247
large tegument protein UL36; Provisional
 974-1240 2.50e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 2.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443057  974 PGSKRFSRKAWRQKRPL-----VQKPLLIQPSPSVQPVFNPGKMATWPTQSEVPPSNTVVQIPHLIQPAAVLQTLPGFPS 1048
Cdd:PHA03247 2658 PGRVSRPRRARRLGRAAqasspPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPA 2737

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443057 1049 VGV--------------------RGEDGFESPTAlPAMPCGSEARTTFPLSETQSAPPSCSAPKLMLPSLAPSKFRKPYV 1108
Cdd:PHA03247 2738 APAppavpagpatpggparparpPTTAGPPAPAP-PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAA 2816

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443057 1109 RRKPTRRKGAKVSPCVKPAPIIHPTPVIFTVPATTVKVVSIGGGCNMIQPVSAAVAPSPQTipittllvnPTTFPCS-LN 1187
Cdd:PHA03247 2817 ALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAA---------PARPPVRrLA 2887

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 226443057 1188 QPLVASSISPLIVSSNPLT------LPVTSIPEDKAQVKLDVAEGKNAPQNPESKLKPQ 1240
Cdd:PHA03247 2888 RPAVSRSTESFALPPDQPErppqpqAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPT 2946
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 1754-1780 6.59e-04

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 39.33  E-value: 6.59e-04
                           10        20
                   ....*....|....*....|....*..
gi 226443057  1754 DIAELKTQMWQLLRGHDHLQDEFSIFF 1780
Cdd:pfam02671   19 DIAEVIARVSELLKGHPDLLEGFNTFL 45
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 986-1285 9.69e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.37  E-value: 9.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443057   986 QKRPLVQKPLLIQPSPSVQPVFNPGKMATWPTQSEVPPS--NTVVQIPHLIQ--PAAVLQTLP--GFPSVGVRGEdGFES 1059
Cdd:pfam03154  232 QQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhGQMPPMPHSLQtgPSHMQHPVPpqPFPLTPQSSQ-SQVP 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443057  1060 PTALPAMPCGSEARTTFPLSetQSAPPSCSAPKLMlpSLAPSKFRKPYVRRKPTrrkgAKVSPCVKPAPIIHPTPVIFTV 1139
Cdd:pfam03154  311 PGPSPAAPGQSQQRIHTPPS--QSQLQSQQPPREQ--PLPPAPLSMPHIKPPPT----TPIPQLPNPQSHKHPPHLSGPS 382

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443057  1140 PATtvkvvsigggcnmiqpVSAAVAPSPQTIPITTLLVN--PTTFPCSL-----NQPLVASSISPLIVSSNPlTLPVTSI 1212
Cdd:pfam03154  383 PFQ----------------MNSNLPPPPALKPLSSLSTHhpPSAHPPPLqlmpqSQQLPPPPAQPPVLTQSQ-SLPPPAA 445

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226443057  1213 PEDKAQVKLDVAEGKNAPQNPESKLKPQELTPLCTtvfskeePKSWHSSADTGSQEAFSESSACSWAVVKTES 1285
Cdd:pfam03154  446 SHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSG-------PPTSTSSAMPGIQPPSSASVSSSGPVPAAVS 511
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
2157-2201 7.58e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 36.43  E-value: 7.58e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 226443057   2157 WTREADRVILTMCQEQGaqPHTFSVISQQLGNKTPVEVSHRFREL 2201
Cdd:smart00717    4 WTEEEDELLIELVKKYG--KNNWEKIAKELPGRTAEQCRERWRNL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 2157-2202 7.90e-03

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 36.40  E-value: 7.90e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 226443057 2157 WTREADRVILTMCQEQGaqPHTFSVISQQLGNKTPVEVSHRFRELM 2202
Cdd:cd00167     2 WTEEEDELLLEAVKKYG--KNNWEKIAKELPGRTPKQCRERWRNLL 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH