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Conserved domains on  [gi|134053952|ref|NP_082239|]
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cilia- and flagella-associated protein 52 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
291-614 4.54e-44

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.39  E-value: 4.54e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 291 GGITSITLRGEGHQFFVGTEESHIYRVNFTDFKETLIATCHFEAVQDIVF-PFGTAeLFATCAKKDIRVWHTMSKRELLR 369
Cdd:COG2319   79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFsPDGKT-LASGSADGTVRLWDLATGKLLRT 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 370 ITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTInSAHRIGVTAIATTSDCKRIISGGGEGEVRVWQVgcQ 449
Cdd:COG2319  158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL--A 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 450 TQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLRRNQMILANT-LFQCVCYHPEEFQIITSGTDRKIAY 528
Cdd:COG2319  235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSgGVNSVAFSPDGKLLASGSDDGTVRL 314

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 529 WEVFDGSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWDYNEGEVTHVGVGHSGNIMAMRISPGNQYIVSVSAD 608
Cdd:COG2319  315 WDLATGKLLRTLTGH-TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393


                 ....*.
gi 134053952 609 GAILRW 614
Cdd:COG2319  394 GTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
10-188 4.45e-16

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.73  E-value: 4.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952  10 DVAELELQAVIGFNGHVPNGLKCHPDQEHLIypLGC---TVLIQAINTNEQ-NFLHGHGNNVSCVTISKEGDYIASGqvt 85
Cdd:COG2319  232 DLATGKLLRTLTGHSGSVRSVAFSPDGRLLA--SGSadgTVRLWDLATGELlRTLTGHSGGVNSVAFSPDGKLLASG--- 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952  86 fmGFKADIILWDFKKRELIARLSLHKGKIEALAFSPNDLYLVSlgGPDDGSVVVWSIAkrDAICGSPAAGlNVGNATSVV 165
Cdd:COG2319  307 --SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLA--TGELLRTLTG-HTGAVTSVA 379

                        170       180
                 ....*....|....*....|....
gi 134053952 166 FSRcRDEMFVTAG-NGTIRVWELD 188
Cdd:COG2319  380 FSP-DGRTLASGSaDGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
291-614 4.54e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.39  E-value: 4.54e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 291 GGITSITLRGEGHQFFVGTEESHIYRVNFTDFKETLIATCHFEAVQDIVF-PFGTAeLFATCAKKDIRVWHTMSKRELLR 369
Cdd:COG2319   79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFsPDGKT-LASGSADGTVRLWDLATGKLLRT 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 370 ITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTInSAHRIGVTAIATTSDCKRIISGGGEGEVRVWQVgcQ 449
Cdd:COG2319  158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL--A 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 450 TQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLRRNQMILANT-LFQCVCYHPEEFQIITSGTDRKIAY 528
Cdd:COG2319  235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSgGVNSVAFSPDGKLLASGSDDGTVRL 314

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 529 WEVFDGSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWDYNEGEVTHVGVGHSGNIMAMRISPGNQYIVSVSAD 608
Cdd:COG2319  315 WDLATGKLLRTLTGH-TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393


                 ....*.
gi 134053952 609 GAILRW 614
Cdd:COG2319  394 GTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 346-615 1.77e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.85  E-value: 1.77e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 346 ELFATCAK-KDIRVWHTMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTINSaHRIGVTAIA 424
Cdd:cd00200   22 KLLATGSGdGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTG-HTSYVSSVA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 425 TTSDCKRIISGGGEGEVRVWQVgcQTQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLRRNQMILANTL 504
Cdd:cd00200  101 FSPDGRILSSSSRDKTIKVWDV--ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 505 F-QCVCYHPEEFQIITSGTDRKIAYWEVFDGSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWDYNEGEVTHVG 583
Cdd:cd00200  179 EvNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL 257

                        250       260       270
                 ....*....|....*....|....*....|..
gi 134053952 584 VGHSGNIMAMRISPGNQYIVSVSADGAILRWK 615
Cdd:cd00200  258 SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
10-188 4.45e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.73  E-value: 4.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952  10 DVAELELQAVIGFNGHVPNGLKCHPDQEHLIypLGC---TVLIQAINTNEQ-NFLHGHGNNVSCVTISKEGDYIASGqvt 85
Cdd:COG2319  232 DLATGKLLRTLTGHSGSVRSVAFSPDGRLLA--SGSadgTVRLWDLATGELlRTLTGHSGGVNSVAFSPDGKLLASG--- 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952  86 fmGFKADIILWDFKKRELIARLSLHKGKIEALAFSPNDLYLVSlgGPDDGSVVVWSIAkrDAICGSPAAGlNVGNATSVV 165
Cdd:COG2319  307 --SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLA--TGELLRTLTG-HTGAVTSVA 379

                        170       180
                 ....*....|....*....|....
gi 134053952 166 FSRcRDEMFVTAG-NGTIRVWELD 188
Cdd:COG2319  380 FSP-DGRTLASGSaDGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 30-399 2.44e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.99  E-value: 2.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952  30 LKCHPDQEHLIypLGC---TVLIQAINTNEQNF-LHGHGNNVSCVTISKEGDYIASGqvtfmGFKADIILWDFKKRELIA 105
Cdd:cd00200   15 VAFSPDGKLLA--TGSgdgTIKVWDLETGELLRtLKGHTGPVRDVAASADGTYLASG-----SSDKTIRLWDLETGECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 106 RLSLHKGKIEALAFSPNDLYLVSlgGPDDGSVVVWSIAKRDaiCGSPAAGLNvGNATSVVFSrcRDEMFVTAG--NGTIR 183
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSS--SSRDKTIKVWDVETGK--CLTTLRGHT-DWVNSVAFS--PDGTFVASSsqDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 184 VWELdlpnrkiwptecqtgqmkrivlstgmadddsffylgtttgdilkmnpktklladtgpvkdkfslgvSALRCLKmgg 263
Cdd:cd00200  161 LWDL------------------------------------------------------------------RTGKCVA--- 171

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 264 LLVGSgagllifckspsykpikkvqlQGGITSITLRGEGHQFFVGTEESHIYRVNFTDFKETLIATCHFEAVQDIVfpFG 343
Cdd:cd00200  172 TLTGH---------------------TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVA--FS 228

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 134053952 344 TAELFATCAKKD--IRVWHTMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDDGKIR 399
Cdd:cd00200  229 PDGYLLASGSEDgtIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIR 286
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 450-489 8.77e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 8.77e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 134053952   450 TQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWD 489
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 100-141 2.08e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 2.08e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 134053952   100 KRELIARLSLHKGKIEALAFSPNDLYLVSLGgpDDGSVVVWS 141
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGS--DDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
457-489 3.60e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 3.60e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 134053952  457 LKEHKSSVSCIRVKKNNEECVTASTDGTCIIWD 489
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 78-142 9.57e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.38  E-value: 9.57e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 134053952  78 YIASgQVTFMGFKADIILWDFKKRELIARLSLHKGKIEALAFSPNDLYLVSlGGPDDGSVVVWSI 142
Cdd:PLN00181 543 YIKS-QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLA-SGSDDGSVKLWSI 605
WD40 pfam00400
WD domain, G-beta repeat;
101-141 8.49e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 8.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 134053952  101 RELIARLSLHKGKIEALAFSPNDLYLVSlGGpDDGSVVVWS 141
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLAS-GS-DDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
291-614 4.54e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.39  E-value: 4.54e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 291 GGITSITLRGEGHQFFVGTEESHIYRVNFTDFKETLIATCHFEAVQDIVF-PFGTAeLFATCAKKDIRVWHTMSKRELLR 369
Cdd:COG2319   79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFsPDGKT-LASGSADGTVRLWDLATGKLLRT 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 370 ITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTInSAHRIGVTAIATTSDCKRIISGGGEGEVRVWQVgcQ 449
Cdd:COG2319  158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL--A 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 450 TQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLRRNQMILANT-LFQCVCYHPEEFQIITSGTDRKIAY 528
Cdd:COG2319  235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSgGVNSVAFSPDGKLLASGSDDGTVRL 314

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 529 WEVFDGSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWDYNEGEVTHVGVGHSGNIMAMRISPGNQYIVSVSAD 608
Cdd:COG2319  315 WDLATGKLLRTLTGH-TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393


                 ....*.
gi 134053952 609 GAILRW 614
Cdd:COG2319  394 GTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
316-614 3.46e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.00  E-value: 3.46e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 316 RVNFTDFKETLIATCHFEAVQDIVFPFGTAELFATCAKKDIRVWHTMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDD 395
Cdd:COG2319   62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAD 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 396 GKIRAFAPESGRLMYTInSAHRIGVTAIATTSDCKRIISGGGEGEVRVWQVgcQTQKLEEALKEHKSSVSCIRVKKNNEE 475
Cdd:COG2319  142 GTVRLWDLATGKLLRTL-TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKL 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 476 CVTASTDGTCIIWDLVRLRRNQMILANTLF-QCVCYHPEEFQIITSGTDRKIAYWEVFDGSVIRELEGSlSGSINGMDIT 554
Cdd:COG2319  219 LASGSADGTVRLWDLATGKLLRTLTGHSGSvRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH-SGGVNSVAFS 297

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 555 QEGGHFVTGGHDHLVKVWDYNEGEVTHVGVGHSGNIMAMRISPGNQYIVSVSADGAILRW 614
Cdd:COG2319  298 PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
331-614 3.20e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.13  E-value: 3.20e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 331 HFEAVQDIVFPFGTAELFATCAKKDIRVWHTMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMY 410
Cdd:COG2319   35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 411 TINsAHRIGVTAIATTSDCKRIISGGGEGEVRVWQVgcQTQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDL 490
Cdd:COG2319  115 TLT-GHTGAVRSVAFSPDGKTLASGSADGTVRLWDL--ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 491 VRLRRNQMILANTLF-QCVCYHPEEFQIITSGTDRKIAYWEVFDGSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLV 569
Cdd:COG2319  192 ATGKLLRTLTGHTGAvRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH-SGSVRSVAFSPDGRLLASGSADGTV 270

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 134053952 570 KVWDYNEGEVTHVGVGHSGNIMAMRISPGNQYIVSVSADGAILRW 614
Cdd:COG2319  271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 346-615 1.77e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.85  E-value: 1.77e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 346 ELFATCAK-KDIRVWHTMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTINSaHRIGVTAIA 424
Cdd:cd00200   22 KLLATGSGdGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTG-HTSYVSSVA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 425 TTSDCKRIISGGGEGEVRVWQVgcQTQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLRRNQMILANTL 504
Cdd:cd00200  101 FSPDGRILSSSSRDKTIKVWDV--ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 505 F-QCVCYHPEEFQIITSGTDRKIAYWEVFDGSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWDYNEGEVTHVG 583
Cdd:cd00200  179 EvNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL 257

                        250       260       270
                 ....*....|....*....|....*....|..
gi 134053952 584 VGHSGNIMAMRISPGNQYIVSVSADGAILRWK 615
Cdd:cd00200  258 SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 380-614 2.37e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 134.77  E-value: 2.37e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 380 IDFMRDGKSIISAWDDGKIRAFAPESGRLMYTiNSAHRIGVTAIATTSDCKRIISGGGEGEVRVWQVgcQTQKLEEALKE 459
Cdd:cd00200   15 VAFSPDGKLLATGSGDGTIKVWDLETGELLRT-LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL--ETGECVRTLTG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 460 HKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLRRNQMILANTLF-QCVCYHPEEFQIITSGTDRKIAYWEVFDGSVIR 538
Cdd:cd00200   92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWvNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA 171

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 134053952 539 ELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWDYNEGEVTHVGVGHSGNIMAMRISPGNQYIVSVSADGAILRW 614
Cdd:cd00200  172 TLTGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
290-573 3.85e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.57  E-value: 3.85e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 290 QGGITSITLRGEGHQFFVGTEESHIYRVNFTDFKETLIATCHFEAVQDIVF-PFGTAeLFATCAKKDIRVWHTMSKRELL 368
Cdd:COG2319  120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFsPDGKL-LASGSDDGTVRLWDLATGKLLR 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 369 RITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTINsAHRIGVTAIATTSDCKRIISGGGEGEVRVWQVgc 448
Cdd:COG2319  199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT-GHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-- 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 449 QTQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLRRNQMILANT-LFQCVCYHPEEFQIITSGTDRKIA 527
Cdd:COG2319  276 ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTgAVRSVAFSPDGKTLASGSDDGTVR 355

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 134053952 528 YWEVFDGSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWD 573
Cdd:COG2319  356 LWDLATGELLRTLTGH-TGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 416-614 1.32e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.29  E-value: 1.32e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 416 HRIGVTAIATTSDCKRIISGGGEGEVRVWQVgcQTQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLvrlrr 495
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDL--ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL----- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 496 NQMILANTLFQ------CVCYHPEEFQIITSGTDRKIAYWEVFDGSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLV 569
Cdd:cd00200   81 ETGECVRTLTGhtsyvsSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 134053952 570 KVWDYNEGEVTHVGVGHSGNIMAMRISPGNQYIVSVSADGAILRW 614
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
46-490 6.23e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.25  E-value: 6.23e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952  46 TVLIQAINTNEQNFLHGHGNNVSCVTISKEGDYIASGqvtfmGFKADIILWDFKKRELIARLSLHKGKIEALAFSPNDLY 125
Cdd:COG2319   60 LLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASA-----SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKT 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 126 LVSlgGPDDGSVVVWSIAKrdaicGSPAAGLNVGNA--TSVVFSRcrD-EMFVTAG-NGTIRVWELDlpnrkiwptecqt 201
Cdd:COG2319  135 LAS--GSADGTVRLWDLAT-----GKLLRTLTGHSGavTSVAFSP--DgKLLASGSdDGTVRLWDLA------------- 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 202 gqmkrivlstgmadddsffylgttTGDILKmnpktKLLADTGPVKD-KFSLGvsalrclkmGGLLVGSGAGllifcksps 280
Cdd:COG2319  193 ------------------------TGKLLR-----TLTGHTGAVRSvAFSPD---------GKLLASGSAD--------- 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 281 ykpiKKVQL---QGGITSITLRGeghqffvgteeshiyrvnftdfketliatcHFEAVQDIVF-PFGTAeLFATCAKKDI 356
Cdd:COG2319  226 ----GTVRLwdlATGKLLRTLTG------------------------------HSGSVRSVAFsPDGRL-LASGSADGTV 270

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 357 RVWHTMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTInSAHRIGVTAIATTSDCKRIISGG 436
Cdd:COG2319  271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKTLASGS 349

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 134053952 437 GEGEVRVWQVgcQTQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDL 490
Cdd:COG2319  350 DDGTVRLWDL--ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
339-614 5.42e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 5.42e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 339 VFPFGTAELFATCAKKDIRVWHTMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTInSAHRI 418
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATL-LGHTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 419 GVTAIATTSDCKRIISGGGEGEVRVWQVgcQTQKLEEALKEHKSSVSCIRVkknneecvtaSTDGTciiwdlvrlrrnqm 498
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDL--ATGLLLRTLTGHTGAVRSVAF----------SPDGK-------------- 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 499 ilantlfqcvcyhpeefQIITSGTDRKIAYWEVFDGSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWDYNEGE 578
Cdd:COG2319  134 -----------------TLASGSADGTVRLWDLATGKLLRTLTGH-SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 134053952 579 VTHVGVGHSGNIMAMRISPGNQYIVSVSADGAILRW 614
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 457-614 3.55e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.24  E-value: 3.55e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 457 LKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDL--VRLRRNQMILANTLFQCVCYHPEEfQIITSGTDRKIAYWEVFDG 534
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLetGELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 535 SVIRELEGSLSGsINGMDITQEGGHFVTGGHDHLVKVWDYNEGEVTHVGVGHSGNIMAMRISPGNQYIVSVSADGAILRW 614
Cdd:cd00200   84 ECVRTLTGHTSY-VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 103-530 2.29e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.93  E-value: 2.29e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 103 LIARLSLHKGKIEALAFSPNDLYLVSLGGpdDGSVVVWSIAKRDAICGSPAAGLNVgnaTSVVFSRCRDEMFVTAGNGTI 182
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSG--DGTIKVWDLETGELLRTLKGHTGPV---RDVAASADGTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 183 RVWELdlpnrkiwptecQTGQMKRIVlsTGmadddsffylgtttgdilkmnpktklladtgpvkdkFSLGVSALRCLKMG 262
Cdd:cd00200   76 RLWDL------------ETGECVRTL--TG------------------------------------HTSYVSSVAFSPDG 105

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 263 GLLVGSGagllifckspsykpikkvqlqggitsitlrgeghqffvgteeshiyrvnftdfketliatchfeavQDivfpf 342
Cdd:cd00200  106 RILSSSS------------------------------------------------------------------RD----- 114

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 343 gtaelfatcakKDIRVWHTMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTInSAHRIGVTA 422
Cdd:cd00200  115 -----------KTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNS 182

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 423 IATTSDCKRIISGGGEGEVRVWQVgcQTQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLRRNQMILA- 501
Cdd:cd00200  183 VAFSPDGEKLLSSSSDGTIKLWDL--STGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGh 260

                        410       420
                 ....*....|....*....|....*....
gi 134053952 502 NTLFQCVCYHPEEFQIITSGTDRKIAYWE 530
Cdd:cd00200  261 TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
10-188 4.45e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.73  E-value: 4.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952  10 DVAELELQAVIGFNGHVPNGLKCHPDQEHLIypLGC---TVLIQAINTNEQ-NFLHGHGNNVSCVTISKEGDYIASGqvt 85
Cdd:COG2319  232 DLATGKLLRTLTGHSGSVRSVAFSPDGRLLA--SGSadgTVRLWDLATGELlRTLTGHSGGVNSVAFSPDGKLLASG--- 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952  86 fmGFKADIILWDFKKRELIARLSLHKGKIEALAFSPNDLYLVSlgGPDDGSVVVWSIAkrDAICGSPAAGlNVGNATSVV 165
Cdd:COG2319  307 --SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLA--TGELLRTLTG-HTGAVTSVA 379

                        170       180
                 ....*....|....*....|....
gi 134053952 166 FSRcRDEMFVTAG-NGTIRVWELD 188
Cdd:COG2319  380 FSP-DGRTLASGSaDGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 30-399 2.44e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.99  E-value: 2.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952  30 LKCHPDQEHLIypLGC---TVLIQAINTNEQNF-LHGHGNNVSCVTISKEGDYIASGqvtfmGFKADIILWDFKKRELIA 105
Cdd:cd00200   15 VAFSPDGKLLA--TGSgdgTIKVWDLETGELLRtLKGHTGPVRDVAASADGTYLASG-----SSDKTIRLWDLETGECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 106 RLSLHKGKIEALAFSPNDLYLVSlgGPDDGSVVVWSIAKRDaiCGSPAAGLNvGNATSVVFSrcRDEMFVTAG--NGTIR 183
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSS--SSRDKTIKVWDVETGK--CLTTLRGHT-DWVNSVAFS--PDGTFVASSsqDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 184 VWELdlpnrkiwptecqtgqmkrivlstgmadddsffylgtttgdilkmnpktklladtgpvkdkfslgvSALRCLKmgg 263
Cdd:cd00200  161 LWDL------------------------------------------------------------------RTGKCVA--- 171

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 264 LLVGSgagllifckspsykpikkvqlQGGITSITLRGEGHQFFVGTEESHIYRVNFTDFKETLIATCHFEAVQDIVfpFG 343
Cdd:cd00200  172 TLTGH---------------------TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVA--FS 228

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 134053952 344 TAELFATCAKKD--IRVWHTMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDDGKIR 399
Cdd:cd00200  229 PDGYLLASGSEDgtIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIR 286
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-188 2.11e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 2.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952  15 ELQAVIGFNGHVpNGLKCHPDQeHLIypLGC----TVLIQAINTNEQNF-LHGHGNNVSCVTISKEGDYIASGqvtfmgf 89
Cdd:cd00200   85 CVRTLTGHTSYV-SSVAFSPDG-RIL--SSSsrdkTIKVWDVETGKCLTtLRGHTDWVNSVAFSPDGTFVASS------- 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952  90 KAD--IILWDFKKRELIARLSLHKGKIEALAFSPNDLYLVSlgGPDDGSVVVWSIAKRDAIC---GSPAAglnvgnATSV 164
Cdd:cd00200  154 SQDgtIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLS--SSSDGTIKLWDLSTGKCLGtlrGHENG------VNSV 225

                        170       180
                 ....*....|....*....|....
gi 134053952 165 VFSRCRDEMFVTAGNGTIRVWELD 188
Cdd:cd00200  226 AFSPDGYLLASGSEDGTIRVWDLR 249
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 60-186 2.19e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 2.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952  60 LHGHGNNVSCVTISKEGDYIASGqvtfmGFKADIILWDFKKRELIARLSLHKGKIEALAFSPNDLYLVSlgGPDDGSVVV 139
Cdd:cd00200  173 LTGHTGEVNSVAFSPDGEKLLSS-----SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS--GSEDGTIRV 245

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 134053952 140 WSIAKRDaiCGSPAAGLNvGNATSVVFSRCRDEMFVTAGNGTIRVWE 186
Cdd:cd00200  246 WDLRTGE--CVQTLSGHT-NSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 537-616 5.72e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.89  E-value: 5.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 537 IRELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWDYNEGEVTHVGVGHSGNIMAMRISPGNQYIVSVSADGAILRWKY 616
Cdd:cd00200    2 RRTLKGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 450-489 8.77e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 8.77e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 134053952   450 TQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWD 489
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 100-141 2.08e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 2.08e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 134053952   100 KRELIARLSLHKGKIEALAFSPNDLYLVSLGgpDDGSVVVWS 141
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGS--DDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 533-573 3.48e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.48e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 134053952   533 DGSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWD 573
Cdd:smart00320   1 SGELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
457-489 3.60e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 3.60e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 134053952  457 LKEHKSSVSCIRVKKNNEECVTASTDGTCIIWD 489
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 78-142 9.57e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.38  E-value: 9.57e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 134053952  78 YIASgQVTFMGFKADIILWDFKKRELIARLSLHKGKIEALAFSPNDLYLVSlGGPDDGSVVVWSI 142
Cdd:PLN00181 543 YIKS-QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLA-SGSDDGSVKLWSI 605
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 577-615 1.17e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.17e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 134053952   577 GEVTHVGVGHSGNIMAMRISPGNQYIVSVSADGAILRWK 615
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
534-573 3.93e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.93e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 134053952  534 GSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWD 573
Cdd:pfam00400   1 GKLLKTLEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 452-520 5.19e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 39.28  E-value: 5.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952  452 KLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLR--------------RNQMILANTLFQCVCYHPEefqI 517
Cdd:pfam20426 115 RMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRssekrsrntqtefpRKDHVIAETPFHILCGHDD---I 191


                  ...
gi 134053952  518 ITS 520
Cdd:pfam20426 192 ITC 194
WD40 pfam00400
WD domain, G-beta repeat;
577-614 7.62e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 7.62e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134053952  577 GEVTHVGVGHSGNIMAMRISPGNQYIVSVSADGAILRW 614
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
101-141 8.49e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 8.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 134053952  101 RELIARLSLHKGKIEALAFSPNDLYLVSlGGpDDGSVVVWS 141
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLAS-GS-DDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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