|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
291-614 |
4.54e-44 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 162.39 E-value: 4.54e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 291 GGITSITLRGEGHQFFVGTEESHIYRVNFTDFKETLIATCHFEAVQDIVF-PFGTAeLFATCAKKDIRVWHTMSKRELLR 369
Cdd:COG2319 79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFsPDGKT-LASGSADGTVRLWDLATGKLLRT 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 370 ITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTInSAHRIGVTAIATTSDCKRIISGGGEGEVRVWQVgcQ 449
Cdd:COG2319 158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL--A 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 450 TQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLRRNQMILANT-LFQCVCYHPEEFQIITSGTDRKIAY 528
Cdd:COG2319 235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSgGVNSVAFSPDGKLLASGSDDGTVRL 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 529 WEVFDGSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWDYNEGEVTHVGVGHSGNIMAMRISPGNQYIVSVSAD 608
Cdd:COG2319 315 WDLATGKLLRTLTGH-TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393
|
....*.
gi 134053952 609 GAILRW 614
Cdd:COG2319 394 GTVRLW 399
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
346-615 |
1.77e-36 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 137.85 E-value: 1.77e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 346 ELFATCAK-KDIRVWHTMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTINSaHRIGVTAIA 424
Cdd:cd00200 22 KLLATGSGdGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTG-HTSYVSSVA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 425 TTSDCKRIISGGGEGEVRVWQVgcQTQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLRRNQMILANTL 504
Cdd:cd00200 101 FSPDGRILSSSSRDKTIKVWDV--ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 505 F-QCVCYHPEEFQIITSGTDRKIAYWEVFDGSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWDYNEGEVTHVG 583
Cdd:cd00200 179 EvNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL 257
|
250 260 270
....*....|....*....|....*....|..
gi 134053952 584 VGHSGNIMAMRISPGNQYIVSVSADGAILRWK 615
Cdd:cd00200 258 SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
10-188 |
4.45e-16 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 80.73 E-value: 4.45e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 10 DVAELELQAVIGFNGHVPNGLKCHPDQEHLIypLGC---TVLIQAINTNEQ-NFLHGHGNNVSCVTISKEGDYIASGqvt 85
Cdd:COG2319 232 DLATGKLLRTLTGHSGSVRSVAFSPDGRLLA--SGSadgTVRLWDLATGELlRTLTGHSGGVNSVAFSPDGKLLASG--- 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 86 fmGFKADIILWDFKKRELIARLSLHKGKIEALAFSPNDLYLVSlgGPDDGSVVVWSIAkrDAICGSPAAGlNVGNATSVV 165
Cdd:COG2319 307 --SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLA--TGELLRTLTG-HTGAVTSVA 379
|
170 180
....*....|....*....|....
gi 134053952 166 FSRcRDEMFVTAG-NGTIRVWELD 188
Cdd:COG2319 380 FSP-DGRTLASGSaDGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
30-399 |
2.44e-15 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 76.99 E-value: 2.44e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 30 LKCHPDQEHLIypLGC---TVLIQAINTNEQNF-LHGHGNNVSCVTISKEGDYIASGqvtfmGFKADIILWDFKKRELIA 105
Cdd:cd00200 15 VAFSPDGKLLA--TGSgdgTIKVWDLETGELLRtLKGHTGPVRDVAASADGTYLASG-----SSDKTIRLWDLETGECVR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 106 RLSLHKGKIEALAFSPNDLYLVSlgGPDDGSVVVWSIAKRDaiCGSPAAGLNvGNATSVVFSrcRDEMFVTAG--NGTIR 183
Cdd:cd00200 88 TLTGHTSYVSSVAFSPDGRILSS--SSRDKTIKVWDVETGK--CLTTLRGHT-DWVNSVAFS--PDGTFVASSsqDGTIK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 184 VWELdlpnrkiwptecqtgqmkrivlstgmadddsffylgtttgdilkmnpktklladtgpvkdkfslgvSALRCLKmgg 263
Cdd:cd00200 161 LWDL------------------------------------------------------------------RTGKCVA--- 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 264 LLVGSgagllifckspsykpikkvqlQGGITSITLRGEGHQFFVGTEESHIYRVNFTDFKETLIATCHFEAVQDIVfpFG 343
Cdd:cd00200 172 TLTGH---------------------TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVA--FS 228
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 134053952 344 TAELFATCAKKD--IRVWHTMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDDGKIR 399
Cdd:cd00200 229 PDGYLLASGSEDgtIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIR 286
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
450-489 |
8.77e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 39.99 E-value: 8.77e-05
10 20 30 40
....*....|....*....|....*....|....*....|
gi 134053952 450 TQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWD 489
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
100-141 |
2.08e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.83 E-value: 2.08e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 134053952 100 KRELIARLSLHKGKIEALAFSPNDLYLVSLGgpDDGSVVVWS 141
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGS--DDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
457-489 |
3.60e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 38.48 E-value: 3.60e-04
10 20 30
....*....|....*....|....*....|...
gi 134053952 457 LKEHKSSVSCIRVKKNNEECVTASTDGTCIIWD 489
Cdd:pfam00400 7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
78-142 |
9.57e-04 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 42.38 E-value: 9.57e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 134053952 78 YIASgQVTFMGFKADIILWDFKKRELIARLSLHKGKIEALAFSPNDLYLVSlGGPDDGSVVVWSI 142
Cdd:PLN00181 543 YIKS-QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLA-SGSDDGSVKLWSI 605
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
101-141 |
8.49e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 34.63 E-value: 8.49e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 134053952 101 RELIARLSLHKGKIEALAFSPNDLYLVSlGGpDDGSVVVWS 141
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLAS-GS-DDGTVKVWD 39
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
291-614 |
4.54e-44 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 162.39 E-value: 4.54e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 291 GGITSITLRGEGHQFFVGTEESHIYRVNFTDFKETLIATCHFEAVQDIVF-PFGTAeLFATCAKKDIRVWHTMSKRELLR 369
Cdd:COG2319 79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFsPDGKT-LASGSADGTVRLWDLATGKLLRT 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 370 ITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTInSAHRIGVTAIATTSDCKRIISGGGEGEVRVWQVgcQ 449
Cdd:COG2319 158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL--A 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 450 TQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLRRNQMILANT-LFQCVCYHPEEFQIITSGTDRKIAY 528
Cdd:COG2319 235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSgGVNSVAFSPDGKLLASGSDDGTVRL 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 529 WEVFDGSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWDYNEGEVTHVGVGHSGNIMAMRISPGNQYIVSVSAD 608
Cdd:COG2319 315 WDLATGKLLRTLTGH-TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393
|
....*.
gi 134053952 609 GAILRW 614
Cdd:COG2319 394 GTVRLW 399
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
316-614 |
3.46e-42 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 157.00 E-value: 3.46e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 316 RVNFTDFKETLIATCHFEAVQDIVFPFGTAELFATCAKKDIRVWHTMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDD 395
Cdd:COG2319 62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAD 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 396 GKIRAFAPESGRLMYTInSAHRIGVTAIATTSDCKRIISGGGEGEVRVWQVgcQTQKLEEALKEHKSSVSCIRVKKNNEE 475
Cdd:COG2319 142 GTVRLWDLATGKLLRTL-TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKL 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 476 CVTASTDGTCIIWDLVRLRRNQMILANTLF-QCVCYHPEEFQIITSGTDRKIAYWEVFDGSVIRELEGSlSGSINGMDIT 554
Cdd:COG2319 219 LASGSADGTVRLWDLATGKLLRTLTGHSGSvRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH-SGGVNSVAFS 297
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 555 QEGGHFVTGGHDHLVKVWDYNEGEVTHVGVGHSGNIMAMRISPGNQYIVSVSADGAILRW 614
Cdd:COG2319 298 PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
331-614 |
3.20e-37 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 143.13 E-value: 3.20e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 331 HFEAVQDIVFPFGTAELFATCAKKDIRVWHTMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMY 410
Cdd:COG2319 35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 411 TINsAHRIGVTAIATTSDCKRIISGGGEGEVRVWQVgcQTQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDL 490
Cdd:COG2319 115 TLT-GHTGAVRSVAFSPDGKTLASGSADGTVRLWDL--ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 491 VRLRRNQMILANTLF-QCVCYHPEEFQIITSGTDRKIAYWEVFDGSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLV 569
Cdd:COG2319 192 ATGKLLRTLTGHTGAvRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH-SGSVRSVAFSPDGRLLASGSADGTV 270
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 134053952 570 KVWDYNEGEVTHVGVGHSGNIMAMRISPGNQYIVSVSADGAILRW 614
Cdd:COG2319 271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
346-615 |
1.77e-36 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 137.85 E-value: 1.77e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 346 ELFATCAK-KDIRVWHTMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTINSaHRIGVTAIA 424
Cdd:cd00200 22 KLLATGSGdGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTG-HTSYVSSVA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 425 TTSDCKRIISGGGEGEVRVWQVgcQTQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLRRNQMILANTL 504
Cdd:cd00200 101 FSPDGRILSSSSRDKTIKVWDV--ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 505 F-QCVCYHPEEFQIITSGTDRKIAYWEVFDGSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWDYNEGEVTHVG 583
Cdd:cd00200 179 EvNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL 257
|
250 260 270
....*....|....*....|....*....|..
gi 134053952 584 VGHSGNIMAMRISPGNQYIVSVSADGAILRWK 615
Cdd:cd00200 258 SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
380-614 |
2.37e-35 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 134.77 E-value: 2.37e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 380 IDFMRDGKSIISAWDDGKIRAFAPESGRLMYTiNSAHRIGVTAIATTSDCKRIISGGGEGEVRVWQVgcQTQKLEEALKE 459
Cdd:cd00200 15 VAFSPDGKLLATGSGDGTIKVWDLETGELLRT-LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL--ETGECVRTLTG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 460 HKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLRRNQMILANTLF-QCVCYHPEEFQIITSGTDRKIAYWEVFDGSVIR 538
Cdd:cd00200 92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWvNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA 171
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 134053952 539 ELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWDYNEGEVTHVGVGHSGNIMAMRISPGNQYIVSVSADGAILRW 614
Cdd:cd00200 172 TLTGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
290-573 |
3.85e-33 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 131.57 E-value: 3.85e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 290 QGGITSITLRGEGHQFFVGTEESHIYRVNFTDFKETLIATCHFEAVQDIVF-PFGTAeLFATCAKKDIRVWHTMSKRELL 368
Cdd:COG2319 120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFsPDGKL-LASGSDDGTVRLWDLATGKLLR 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 369 RITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTINsAHRIGVTAIATTSDCKRIISGGGEGEVRVWQVgc 448
Cdd:COG2319 199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT-GHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-- 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 449 QTQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLRRNQMILANT-LFQCVCYHPEEFQIITSGTDRKIA 527
Cdd:COG2319 276 ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTgAVRSVAFSPDGKTLASGSDDGTVR 355
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 134053952 528 YWEVFDGSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWD 573
Cdd:COG2319 356 LWDLATGELLRTLTGH-TGAVTSVAFSPDGRTLASGSADGTVRLWD 400
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
416-614 |
1.32e-30 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 121.29 E-value: 1.32e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 416 HRIGVTAIATTSDCKRIISGGGEGEVRVWQVgcQTQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLvrlrr 495
Cdd:cd00200 8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDL--ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL----- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 496 NQMILANTLFQ------CVCYHPEEFQIITSGTDRKIAYWEVFDGSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLV 569
Cdd:cd00200 81 ETGECVRTLTGhtsyvsSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDGTFVASSSQDGTI 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 134053952 570 KVWDYNEGEVTHVGVGHSGNIMAMRISPGNQYIVSVSADGAILRW 614
Cdd:cd00200 160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
46-490 |
6.23e-29 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 119.25 E-value: 6.23e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 46 TVLIQAINTNEQNFLHGHGNNVSCVTISKEGDYIASGqvtfmGFKADIILWDFKKRELIARLSLHKGKIEALAFSPNDLY 125
Cdd:COG2319 60 LLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASA-----SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKT 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 126 LVSlgGPDDGSVVVWSIAKrdaicGSPAAGLNVGNA--TSVVFSRcrD-EMFVTAG-NGTIRVWELDlpnrkiwptecqt 201
Cdd:COG2319 135 LAS--GSADGTVRLWDLAT-----GKLLRTLTGHSGavTSVAFSP--DgKLLASGSdDGTVRLWDLA------------- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 202 gqmkrivlstgmadddsffylgttTGDILKmnpktKLLADTGPVKD-KFSLGvsalrclkmGGLLVGSGAGllifcksps 280
Cdd:COG2319 193 ------------------------TGKLLR-----TLTGHTGAVRSvAFSPD---------GKLLASGSAD--------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 281 ykpiKKVQL---QGGITSITLRGeghqffvgteeshiyrvnftdfketliatcHFEAVQDIVF-PFGTAeLFATCAKKDI 356
Cdd:COG2319 226 ----GTVRLwdlATGKLLRTLTG------------------------------HSGSVRSVAFsPDGRL-LASGSADGTV 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 357 RVWHTMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTInSAHRIGVTAIATTSDCKRIISGG 436
Cdd:COG2319 271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKTLASGS 349
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 134053952 437 GEGEVRVWQVgcQTQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDL 490
Cdd:COG2319 350 DDGTVRLWDL--ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
339-614 |
5.42e-23 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 101.53 E-value: 5.42e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 339 VFPFGTAELFATCAKKDIRVWHTMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTInSAHRI 418
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATL-LGHTA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 419 GVTAIATTSDCKRIISGGGEGEVRVWQVgcQTQKLEEALKEHKSSVSCIRVkknneecvtaSTDGTciiwdlvrlrrnqm 498
Cdd:COG2319 80 AVLSVAFSPDGRLLASASADGTVRLWDL--ATGLLLRTLTGHTGAVRSVAF----------SPDGK-------------- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 499 ilantlfqcvcyhpeefQIITSGTDRKIAYWEVFDGSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWDYNEGE 578
Cdd:COG2319 134 -----------------TLASGSADGTVRLWDLATGKLLRTLTGH-SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195
|
250 260 270
....*....|....*....|....*....|....*.
gi 134053952 579 VTHVGVGHSGNIMAMRISPGNQYIVSVSADGAILRW 614
Cdd:COG2319 196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
457-614 |
3.55e-20 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 91.24 E-value: 3.55e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 457 LKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDL--VRLRRNQMILANTLFQCVCYHPEEfQIITSGTDRKIAYWEVFDG 534
Cdd:cd00200 5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLetGELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLETG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 535 SVIRELEGSLSGsINGMDITQEGGHFVTGGHDHLVKVWDYNEGEVTHVGVGHSGNIMAMRISPGNQYIVSVSADGAILRW 614
Cdd:cd00200 84 ECVRTLTGHTSY-VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
103-530 |
2.29e-19 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 88.93 E-value: 2.29e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 103 LIARLSLHKGKIEALAFSPNDLYLVSLGGpdDGSVVVWSIAKRDAICGSPAAGLNVgnaTSVVFSRCRDEMFVTAGNGTI 182
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSG--DGTIKVWDLETGELLRTLKGHTGPV---RDVAASADGTYLASGSSDKTI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 183 RVWELdlpnrkiwptecQTGQMKRIVlsTGmadddsffylgtttgdilkmnpktklladtgpvkdkFSLGVSALRCLKMG 262
Cdd:cd00200 76 RLWDL------------ETGECVRTL--TG------------------------------------HTSYVSSVAFSPDG 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 263 GLLVGSGagllifckspsykpikkvqlqggitsitlrgeghqffvgteeshiyrvnftdfketliatchfeavQDivfpf 342
Cdd:cd00200 106 RILSSSS------------------------------------------------------------------RD----- 114
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 343 gtaelfatcakKDIRVWHTMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTInSAHRIGVTA 422
Cdd:cd00200 115 -----------KTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNS 182
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 423 IATTSDCKRIISGGGEGEVRVWQVgcQTQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLRRNQMILA- 501
Cdd:cd00200 183 VAFSPDGEKLLSSSSDGTIKLWDL--STGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGh 260
|
410 420
....*....|....*....|....*....
gi 134053952 502 NTLFQCVCYHPEEFQIITSGTDRKIAYWE 530
Cdd:cd00200 261 TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
10-188 |
4.45e-16 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 80.73 E-value: 4.45e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 10 DVAELELQAVIGFNGHVPNGLKCHPDQEHLIypLGC---TVLIQAINTNEQ-NFLHGHGNNVSCVTISKEGDYIASGqvt 85
Cdd:COG2319 232 DLATGKLLRTLTGHSGSVRSVAFSPDGRLLA--SGSadgTVRLWDLATGELlRTLTGHSGGVNSVAFSPDGKLLASG--- 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 86 fmGFKADIILWDFKKRELIARLSLHKGKIEALAFSPNDLYLVSlgGPDDGSVVVWSIAkrDAICGSPAAGlNVGNATSVV 165
Cdd:COG2319 307 --SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLA--TGELLRTLTG-HTGAVTSVA 379
|
170 180
....*....|....*....|....
gi 134053952 166 FSRcRDEMFVTAG-NGTIRVWELD 188
Cdd:COG2319 380 FSP-DGRTLASGSaDGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
30-399 |
2.44e-15 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 76.99 E-value: 2.44e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 30 LKCHPDQEHLIypLGC---TVLIQAINTNEQNF-LHGHGNNVSCVTISKEGDYIASGqvtfmGFKADIILWDFKKRELIA 105
Cdd:cd00200 15 VAFSPDGKLLA--TGSgdgTIKVWDLETGELLRtLKGHTGPVRDVAASADGTYLASG-----SSDKTIRLWDLETGECVR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 106 RLSLHKGKIEALAFSPNDLYLVSlgGPDDGSVVVWSIAKRDaiCGSPAAGLNvGNATSVVFSrcRDEMFVTAG--NGTIR 183
Cdd:cd00200 88 TLTGHTSYVSSVAFSPDGRILSS--SSRDKTIKVWDVETGK--CLTTLRGHT-DWVNSVAFS--PDGTFVASSsqDGTIK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 184 VWELdlpnrkiwptecqtgqmkrivlstgmadddsffylgtttgdilkmnpktklladtgpvkdkfslgvSALRCLKmgg 263
Cdd:cd00200 161 LWDL------------------------------------------------------------------RTGKCVA--- 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 264 LLVGSgagllifckspsykpikkvqlQGGITSITLRGEGHQFFVGTEESHIYRVNFTDFKETLIATCHFEAVQDIVfpFG 343
Cdd:cd00200 172 TLTGH---------------------TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVA--FS 228
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 134053952 344 TAELFATCAKKD--IRVWHTMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDDGKIR 399
Cdd:cd00200 229 PDGYLLASGSEDgtIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIR 286
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
15-188 |
2.11e-13 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 71.21 E-value: 2.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 15 ELQAVIGFNGHVpNGLKCHPDQeHLIypLGC----TVLIQAINTNEQNF-LHGHGNNVSCVTISKEGDYIASGqvtfmgf 89
Cdd:cd00200 85 CVRTLTGHTSYV-SSVAFSPDG-RIL--SSSsrdkTIKVWDVETGKCLTtLRGHTDWVNSVAFSPDGTFVASS------- 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 90 KAD--IILWDFKKRELIARLSLHKGKIEALAFSPNDLYLVSlgGPDDGSVVVWSIAKRDAIC---GSPAAglnvgnATSV 164
Cdd:cd00200 154 SQDgtIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLS--SSSDGTIKLWDLSTGKCLGtlrGHENG------VNSV 225
|
170 180
....*....|....*....|....
gi 134053952 165 VFSRCRDEMFVTAGNGTIRVWELD 188
Cdd:cd00200 226 AFSPDGYLLASGSEDGTIRVWDLR 249
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
60-186 |
2.19e-12 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 68.13 E-value: 2.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 60 LHGHGNNVSCVTISKEGDYIASGqvtfmGFKADIILWDFKKRELIARLSLHKGKIEALAFSPNDLYLVSlgGPDDGSVVV 139
Cdd:cd00200 173 LTGHTGEVNSVAFSPDGEKLLSS-----SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS--GSEDGTIRV 245
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 134053952 140 WSIAKRDaiCGSPAAGLNvGNATSVVFSRCRDEMFVTAGNGTIRVWE 186
Cdd:cd00200 246 WDLRTGE--CVQTLSGHT-NSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
537-616 |
5.72e-11 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 63.89 E-value: 5.72e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 537 IRELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWDYNEGEVTHVGVGHSGNIMAMRISPGNQYIVSVSADGAILRWKY 616
Cdd:cd00200 2 RRTLKGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
450-489 |
8.77e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 39.99 E-value: 8.77e-05
10 20 30 40
....*....|....*....|....*....|....*....|
gi 134053952 450 TQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWD 489
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
100-141 |
2.08e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.83 E-value: 2.08e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 134053952 100 KRELIARLSLHKGKIEALAFSPNDLYLVSLGgpDDGSVVVWS 141
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGS--DDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
533-573 |
3.48e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.45 E-value: 3.48e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 134053952 533 DGSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWD 573
Cdd:smart00320 1 SGELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
457-489 |
3.60e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 38.48 E-value: 3.60e-04
10 20 30
....*....|....*....|....*....|...
gi 134053952 457 LKEHKSSVSCIRVKKNNEECVTASTDGTCIIWD 489
Cdd:pfam00400 7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
78-142 |
9.57e-04 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 42.38 E-value: 9.57e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 134053952 78 YIASgQVTFMGFKADIILWDFKKRELIARLSLHKGKIEALAFSPNDLYLVSlGGPDDGSVVVWSI 142
Cdd:PLN00181 543 YIKS-QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLA-SGSDDGSVKLWSI 605
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
577-615 |
1.17e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 36.91 E-value: 1.17e-03
10 20 30
....*....|....*....|....*....|....*....
gi 134053952 577 GEVTHVGVGHSGNIMAMRISPGNQYIVSVSADGAILRWK 615
Cdd:smart00320 2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
534-573 |
3.93e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 35.40 E-value: 3.93e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 134053952 534 GSVIRELEGSlSGSINGMDITQEGGHFVTGGHDHLVKVWD 573
Cdd:pfam00400 1 GKLLKTLEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| NBCH_WD40 |
pfam20426 |
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ... |
452-520 |
5.19e-03 |
|
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.
Pssm-ID: 466575 [Multi-domain] Cd Length: 350 Bit Score: 39.28 E-value: 5.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053952 452 KLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLR--------------RNQMILANTLFQCVCYHPEefqI 517
Cdd:pfam20426 115 RMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRssekrsrntqtefpRKDHVIAETPFHILCGHDD---I 191
|
...
gi 134053952 518 ITS 520
Cdd:pfam20426 192 ITC 194
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
577-614 |
7.62e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 34.63 E-value: 7.62e-03
10 20 30
....*....|....*....|....*....|....*...
gi 134053952 577 GEVTHVGVGHSGNIMAMRISPGNQYIVSVSADGAILRW 614
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
101-141 |
8.49e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 34.63 E-value: 8.49e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 134053952 101 RELIARLSLHKGKIEALAFSPNDLYLVSlGGpDDGSVVVWS 141
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLAS-GS-DDGTVKVWD 39
|
|
|