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Conserved domains on  [gi|21361933|ref|NP_110417|]
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T-cell immunomodulatory protein isoform 1 precursor [Homo sapiens]

Protein Classification

FG-GAP repeat domain-containing protein( domain architecture ID 10608042)

FG-GAP (VCBS) repeat domain-containing protein characterized by a repeat region that is found in up to seven copies in alpha integrins and related proteins. It forms a 7-fold repeat that adopts a beta-propeller structure

PubMed:  33416871

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 55-118 1.22e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


:

Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 42.98  E-value: 1.22e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21361933    55 DLNSDKQTDLFVLReRNDLIVFLADQNAPyFKPKVKVSFkNHSALITSVVPGDYDGDSQMDVLL 118
Cdd:pfam13517   1 DLDGDGKLDLVVAN-DGGLRLYLNNGDGT-FTFITSVSL-GGGGGGLSVAVGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 266-349 5.59e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


:

Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 35.66  E-value: 5.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361933   266 DFDGDGHMDhllpgcedkncqkstIYLVRSGMKQWVpvlqDFSNKGTLWgfvpFVDEQQPTEIPIPITLHIGDYNMDGYP 345
Cdd:pfam13517   1 DLDGDGKLD---------------LVVANDGGLRLY----LNNGDGTFT----FITSVSLGGGGGGLSVAVGDLDGDGRL 57


                  ....
gi 21361933   346 DALV 349
Cdd:pfam13517  58 DLLV 61
 
Name Accession Description Interval E-value
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 55-118 1.22e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 42.98  E-value: 1.22e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21361933    55 DLNSDKQTDLFVLReRNDLIVFLADQNAPyFKPKVKVSFkNHSALITSVVPGDYDGDSQMDVLL 118
Cdd:pfam13517   1 DLDGDGKLDLVVAN-DGGLRLYLNNGDGT-FTFITSVSL-GGGGGGLSVAVGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 266-349 5.59e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 35.66  E-value: 5.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361933   266 DFDGDGHMDhllpgcedkncqkstIYLVRSGMKQWVpvlqDFSNKGTLWgfvpFVDEQQPTEIPIPITLHIGDYNMDGYP 345
Cdd:pfam13517   1 DLDGDGKLD---------------LVVANDGGLRLY----LNNGDGTFT----FITSVSLGGGGGGLSVAVGDLDGDGRL 57


                  ....
gi 21361933   346 DALV 349
Cdd:pfam13517  58 DLLV 61
 
Name Accession Description Interval E-value
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 55-118 1.22e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 42.98  E-value: 1.22e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21361933    55 DLNSDKQTDLFVLReRNDLIVFLADQNAPyFKPKVKVSFkNHSALITSVVPGDYDGDSQMDVLL 118
Cdd:pfam13517   1 DLDGDGKLDLVVAN-DGGLRLYLNNGDGT-FTFITSVSL-GGGGGGLSVAVGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 266-349 5.59e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 35.66  E-value: 5.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361933   266 DFDGDGHMDhllpgcedkncqkstIYLVRSGMKQWVpvlqDFSNKGTLWgfvpFVDEQQPTEIPIPITLHIGDYNMDGYP 345
Cdd:pfam13517   1 DLDGDGKLD---------------LVVANDGGLRLY----LNNGDGTFT----FITSVSLGGGGGGLSVAVGDLDGDGRL 57


                  ....
gi 21361933   346 DALV 349
Cdd:pfam13517  58 DLLV 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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