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Conserved domains on  [gi|93204885|ref|NP_112195|]
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testicular spindle-associated protein SHCBP1L isoform 1 [Homo sapiens]

Protein Classification

right-handed parallel beta-helix repeat-containing protein( domain architecture ID 12131601)

right-handed parallel beta-helix repeat-containing protein that may share some similarity with pectate lyases, similar to Bacteroides thetaiotaomicron alpha-1,3-galactosidase B that removes both branched alpha-1,3-linked galactose residues of blood group B antigens and linear alpha-1,3-linked galactose structures

PubMed:  38767844

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 486-653 2.69e-15

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


:

Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 73.60  E-value: 2.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93204885   486 DGIVVVESGHMTLENC-ILKCEGTGVCVLTGAALTITDSEITGAQGAGVELYPGSIAILERNEIHHCNNlrtsnsskstl 564
Cdd:pfam13229   1 SGILLNGSSNATIKNNtISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNNTISNNTISNNGG----------- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93204885   565 GGVnmKVLPAPKLKMTNNHIYSNKGYGVSILQpmEQFFIVAEEALNKRASSGdkkddkmlFKVMQN-LNLEMNNNKIEAN 643
Cdd:pfam13229  70 GGI--ALRGSSNNLIENNTISNNGGAGIYLSD--SSNNTIENNIIHNNGGSG--------IVIEDSsNNVTISNNTVTNN 137

                         170
                  ....*....|
gi 93204885   644 VKGDIRIVTS 653
Cdd:pfam13229 138 KGAGILIVGG 147
 
Name Accession Description Interval E-value
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 486-653 2.69e-15

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 73.60  E-value: 2.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93204885   486 DGIVVVESGHMTLENC-ILKCEGTGVCVLTGAALTITDSEITGAQGAGVELYPGSIAILERNEIHHCNNlrtsnsskstl 564
Cdd:pfam13229   1 SGILLNGSSNATIKNNtISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNNTISNNTISNNGG----------- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93204885   565 GGVnmKVLPAPKLKMTNNHIYSNKGYGVSILQpmEQFFIVAEEALNKRASSGdkkddkmlFKVMQN-LNLEMNNNKIEAN 643
Cdd:pfam13229  70 GGI--ALRGSSNNLIENNTISNNGGAGIYLSD--SSNNTIENNIIHNNGGSG--------IVIEDSsNNVTISNNTVTNN 137

                         170
                  ....*....|
gi 93204885   644 VKGDIRIVTS 653
Cdd:pfam13229 138 KGAGILIVGG 147
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 405-594 6.58e-10

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 61.09  E-value: 6.58e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93204885 405 QQHGDLDLALDNCYSGDTVIIFPGEYqAANLaLLTDDIIIKGVGKreeIMITSEPSRDSFVVsKADNVKLMHLSLIQQGT 484
Cdd:COG3420  19 APGDSLQAAIDAAPPGDTIEVPPGTY-EGNI-VIDKPLTLIGEGG---AVIDGGGKGTVITI-TADNVTVRGLTITGSGD 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93204885 485 VD-----GIVVVESGHMTLENCILKCEGTGVCVLTGAALTITDSEITGAQ------GAGVELY--PGSI----------- 540
Cdd:COG3420  93 SLtdddaGIYVRGADNAVIENNRIENNLFGIYLEGSDNNVIRNNTISGNRdlradrGNGIHLWnsPGNViegntisggrd 172

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 93204885 541 ---------AILERNEIHHC----------NNLRTSNSSKSTLGGVnmKVLPAPKLKMTNNHIYSNKGYGVSI 594
Cdd:COG3420 173 giylefsdnNVIRNNTIRNLrygihymysnDNLVEGNTFRDNGAGI--ALMYSKGNTVRGNTILGNSGYGILL 243
 
Name Accession Description Interval E-value
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 486-653 2.69e-15

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 73.60  E-value: 2.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93204885   486 DGIVVVESGHMTLENC-ILKCEGTGVCVLTGAALTITDSEITGAQGAGVELYPGSIAILERNEIHHCNNlrtsnsskstl 564
Cdd:pfam13229   1 SGILLNGSSNATIKNNtISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNNTISNNTISNNGG----------- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93204885   565 GGVnmKVLPAPKLKMTNNHIYSNKGYGVSILQpmEQFFIVAEEALNKRASSGdkkddkmlFKVMQN-LNLEMNNNKIEAN 643
Cdd:pfam13229  70 GGI--ALRGSSNNLIENNTISNNGGAGIYLSD--SSNNTIENNIIHNNGGSG--------IVIEDSsNNVTISNNTVTNN 137

                         170
                  ....*....|
gi 93204885   644 VKGDIRIVTS 653
Cdd:pfam13229 138 KGAGILIVGG 147
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 405-594 6.58e-10

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 61.09  E-value: 6.58e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93204885 405 QQHGDLDLALDNCYSGDTVIIFPGEYqAANLaLLTDDIIIKGVGKreeIMITSEPSRDSFVVsKADNVKLMHLSLIQQGT 484
Cdd:COG3420  19 APGDSLQAAIDAAPPGDTIEVPPGTY-EGNI-VIDKPLTLIGEGG---AVIDGGGKGTVITI-TADNVTVRGLTITGSGD 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93204885 485 VD-----GIVVVESGHMTLENCILKCEGTGVCVLTGAALTITDSEITGAQ------GAGVELY--PGSI----------- 540
Cdd:COG3420  93 SLtdddaGIYVRGADNAVIENNRIENNLFGIYLEGSDNNVIRNNTISGNRdlradrGNGIHLWnsPGNViegntisggrd 172

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 93204885 541 ---------AILERNEIHHC----------NNLRTSNSSKSTLGGVnmKVLPAPKLKMTNNHIYSNKGYGVSI 594
Cdd:COG3420 173 giylefsdnNVIRNNTIRNLrygihymysnDNLVEGNTFRDNGAGI--ALMYSKGNTVRGNTILGNSGYGILL 243
NosD pfam05048
Periplasmic copper-binding protein (NosD); NosD is a periplasmic protein which is thought to ...
 414-595 4.29e-09

Periplasmic copper-binding protein (NosD); NosD is a periplasmic protein which is thought to insert copper into the exported reductase apoenzyme (NosZ). This region forms a parallel beta helix domain.


Pssm-ID: 428281 [Multi-domain]  Cd Length: 215  Bit Score: 57.04  E-value: 4.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93204885   414 LDNCYSGDTVIIFPGEYqaanlalLTDDIIIKGVGKREEIMITSEPSRDSFVVSKADNVKLMHLSLiqQGTVDGIVVVES 493
Cdd:pfam05048   1 VNNAISGDTIGIYNGLS-------RGNGIQLWNTEGNVISNNDIINSRDGIYLDASNNNTITGNRI--SNLRYGIHLMNS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93204885   494 GHMTLENCILKCEGTGVCVLTGAALTITDSEITGAQGAGVELYPGSIAILERNEIHHCNN--LRTSNSSKSTLggvnmkv 571
Cdd:pfam05048  72 NDNTISDNVFSGNTAGIALMSSSNNTLENNTISGNTNYGILLSDSSNNTISNNTISNNNGkgIFLYNSDYNTI------- 144

                         170       180
                  ....*....|....*....|....
gi 93204885   572 lpapklkmTNNHIYSNkGYGVSIL 595
Cdd:pfam05048 145 --------TGNRITSN-GIGIHFL 159
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 460-594 1.28e-04

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 44.52  E-value: 1.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93204885 460 SRDSFVVSKADNvklmhlSLIQQGTVD----GIVVVESGHMTLENCILKCEGTGVCVLTGAALTITDSEITGAQGAGVEL 535
Cdd:COG3420 170 GRDGIYLEFSDN------NVIRNNTIRnlryGIHYMYSNDNLVEGNTFRDNGAGIALMYSKGNTVRGNTILGNSGYGILL 243

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 93204885 536 YPGSIAILERNEIHHCNN-LRTSNSSKSTLggvnmkvlpapklkmTNNHIYSNkGYGVSI 594
Cdd:COG3420 244 KESSDSVIEGNTISGNGKgIFIYNSNRNTI---------------RGNLFAGN-GIGIHL 287
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 486-548 4.42e-04

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 41.24  E-value: 4.42e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 93204885   486 DGIVVVESGHMTLENCILK-CEGTGVCVLTGAA-LTITDSEITGAQGAGVELYPGS-IAILERNEI 548
Cdd:pfam13229  93 AGIYLSDSSNNTIENNIIHnNGGSGIVIEDSSNnVTISNNTVTNNKGAGILIVGGSsNNTVENNTF 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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