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Conserved domains on  [gi|291219898|ref|NP_112237|]
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keratin-associated protein 9-9 isoform KRTAP9.5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 12-168 2.69e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 69.05  E-value: 2.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291219898   12 TCCRTTCWKPTTVTTCSS--TPCCQPSCCVSSCCQP-CCRPACCQNTCCRTTCCQPTClTSCCQPSCCSTTCCQPICCGS 88
Cdd:pfam01500   2 ACCGTSFCGFPTCSTGGTcgSGCCQPCCCQSSCCRPsCCQTSCCQPTTFQSSCCRPTC-QPCCQTSCCQPTCCQTSSCQT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291219898   89 SCCGQTSCGSSCGQSSSCAPVYCRRTCYYPTTVCLPGCLNQSCGSSCCQ------PCCRPACCETTCCrttcfQPTCVSS 162
Cdd:pfam01500  81 GCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQlhhaqaSCCRPSYCGQSCC-----RPACCCQ 155


                  ....*.
gi 291219898  163 CCQPSC 168
Cdd:pfam01500 156 CSEPTC 161
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 12-168 2.69e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 69.05  E-value: 2.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291219898   12 TCCRTTCWKPTTVTTCSS--TPCCQPSCCVSSCCQP-CCRPACCQNTCCRTTCCQPTClTSCCQPSCCSTTCCQPICCGS 88
Cdd:pfam01500   2 ACCGTSFCGFPTCSTGGTcgSGCCQPCCCQSSCCRPsCCQTSCCQPTTFQSSCCRPTC-QPCCQTSCCQPTCCQTSSCQT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291219898   89 SCCGQTSCGSSCGQSSSCAPVYCRRTCYYPTTVCLPGCLNQSCGSSCCQ------PCCRPACCETTCCrttcfQPTCVSS 162
Cdd:pfam01500  81 GCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQlhhaqaSCCRPSYCGQSCC-----RPACCCQ 155


                  ....*.
gi 291219898  163 CCQPSC 168
Cdd:pfam01500 156 CSEPTC 161
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
32-86 2.21e-03

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 37.61  E-value: 2.21e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 291219898  32 CCQPSCCVSSCCQPCCRPACCQNTCCRTTCCQPTCLTSCCQPSCCSTTCCQPICC 86
Cdd:COG3901  628 RRRRRECCCGCCCCCCKCCCIVIIIDGIIIINECCCCCCLCCRRCQDDPLCPPRI 682
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 12-168 2.69e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 69.05  E-value: 2.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291219898   12 TCCRTTCWKPTTVTTCSS--TPCCQPSCCVSSCCQP-CCRPACCQNTCCRTTCCQPTClTSCCQPSCCSTTCCQPICCGS 88
Cdd:pfam01500   2 ACCGTSFCGFPTCSTGGTcgSGCCQPCCCQSSCCRPsCCQTSCCQPTTFQSSCCRPTC-QPCCQTSCCQPTCCQTSSCQT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291219898   89 SCCGQTSCGSSCGQSSSCAPVYCRRTCYYPTTVCLPGCLNQSCGSSCCQ------PCCRPACCETTCCrttcfQPTCVSS 162
Cdd:pfam01500  81 GCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQlhhaqaSCCRPSYCGQSCC-----RPACCCQ 155


                  ....*.
gi 291219898  163 CCQPSC 168
Cdd:pfam01500 156 CSEPTC 161
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
32-76 6.29e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 49.30  E-value: 6.29e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 291219898   32 CCQPSCCVSSCCQP-CCRPACCQNTCCRTTCCQPtcltSCCQPSCC 76
Cdd:pfam13885   1 CCQPSCCQPSCCQPsCCQPSCCQPSCCQPSCCRP----SCCRSSCC 42
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
27-70 1.18e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.53  E-value: 1.18e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 291219898   27 CSSTPCCQPSCCVSSCCQP-CCRPACCQNTCCRTTCCQPTCLTSC 70
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPsCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
8-65 6.81e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 46.61  E-value: 6.81e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 291219898    8 CCQPTCCRTTCwkpttvttcsstpcCQPSCCVSSCCQP-CCRPACCQNTCCRTTCCQPT 65
Cdd:pfam13885   1 CCQPSCCQPSC--------------CQPSCCQPSCCQPsCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
51-91 2.51e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 45.07  E-value: 2.51e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 291219898   51 CCQNTCCRTTCCQPtcltSCCQPSCCSTTCCQPICCGSSCC 91
Cdd:pfam13885   1 CCQPSCCQPSCCQP----SCCQPSCCQPSCCQPSCCRPSCC 37
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
75-119 1.01e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 35.44  E-value: 1.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 291219898   75 CCSTTCCQPICCGSSCCGQTSCGSSCGQSSSCAPVYCRRTCYYPT 119
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
4-46 1.73e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 34.67  E-value: 1.73e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 291219898    4 CCSPCCQPTCCRTTCWKPTtvttcsstpCCQPSCCVSSCCQPC 46
Cdd:pfam13885  12 CQPSCCQPSCCQPSCCQPS---------CCRPSCCRSSCCQPT 45
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
32-86 2.21e-03

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 37.61  E-value: 2.21e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 291219898  32 CCQPSCCVSSCCQPCCRPACCQNTCCRTTCCQPTCLTSCCQPSCCSTTCCQPICC 86
Cdd:COG3901  628 RRRRRECCCGCCCCCCKCCCIVIIIDGIIIINECCCCCCLCCRRCQDDPLCPPRI 682
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 4-66 4.62e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 35.92  E-value: 4.62e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 291219898    4 CCSPCCQPTCCRTTCWKPTTVTTCSS-TPCCQPSCCVSSCCQPCCrpaCCQntccrttCCQPTC 66
Cdd:pfam01500 108 RVEGTCLPPCCVVSCTPPTCCQLHHAqASCCRPSYCGQSCCRPAC---CCQ-------CSEPTC 161
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 1-133 6.43e-03

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 35.56  E-value: 6.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291219898    1 MTHCCSPCCQPTCCRTTCwkptTVTTCSSTPCCQPSCCVSSCCQPccRPACCQNTCCRTTCCQPTCLTSCCQPSCCSTTC 80
Cdd:pfam05287  53 RDNCQETCGEPTSCQTSS----CEPCTSSTSYCVPSPCQRSCYSP--RTSCVCSPCQTTSAGSLGFGSSSCQSLGYGSNS 126

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 291219898   81 CQPICCGSSCCGQTSCGSSCGQSSSCAPVYCRRTCyYPTTVCLPGCLNQSCGS 133
Cdd:pfam05287 127 CQPLGCGSSGFRPLGCLSKGFQSLGYGSSFCRPSY-VSSRSYQPSCFRPSCGS 178
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
1-91 6.85e-03

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 36.16  E-value: 6.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291219898   1 MTHCCSPCCQPTCCRTTC---WKPTTVTTCSSTPCCQPSCCVSSCCQPCCRPACCQNTCCRTTCCQPTCLTSCCQPSCCS 77
Cdd:COG4624    6 RACCCCCIEEGDELLLLEeaeRVLRIIILEALLPEHVDDDSACSCCPRCCLCCCCCCRCCVAISCIQVRGIIIIDKRGPS 85

                         90
                 ....*....|....
gi 291219898  78 TTCCQPICCGSSCC 91
Cdd:COG4624   86 IIRDKEKCKNCYPC 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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