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Conserved domains on  [gi|13775238|ref|NP_112600|]
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plasmalemma vesicle-associated protein [Homo sapiens]

Protein Classification

PV-1 domain-containing protein( domain architecture ID 12071456)

PV-1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PV-1 pfam06637
PV-1 protein (PLVAP); This family consists of several PV-1 (PLVAP) proteins which seem to be ...
 2-440 0e+00

PV-1 protein (PLVAP); This family consists of several PV-1 (PLVAP) proteins which seem to be specific to mammals. PV-1 is a novel protein component of the endothelial fenestral and stomatal diaphragms. The function of this family is unknown.


:

Pssm-ID: 461970 [Multi-domain]  Cd Length: 439  Bit Score: 834.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238     2 GLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQ 81
Cdd:pfam06637   1 GLAMEHGGAYARAGGSPRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQVVGLTASQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238    82 SNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFML 161
Cdd:pfam06637  81 ANLSKELNLTARAKDAIMQMLLSARRDLDRINASFRQCQGDRVIYINNQRYMAAIILSEKQCQEQLKEANKSCDALLLML 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   162 NQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLW 241
Cdd:pfam06637 161 GQKAKTLEVELAKEKAVCTKDKESLLLSKRVAEEQLAECGKAREQQQQERQLAEDRLQKVQSLCLPLDKDKFETDLRNLW 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   242 RDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEA 321
Cdd:pfam06637 241 RDSIIPRTLDTLGYNLYHPLGSELASIRRTCDSLPSIMSTKVEELARSLRAGIERVARENSDLQRQKLEAEQSLRASQEA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   322 KQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVS 401
Cdd:pfam06637 321 KEKVEKEAQAREAKLQAECARQTQLALEEKAVLRKERDNLAKELEEKKREVEQLKMQLAVRNSALDTCIKAKSQPAIPLP 400

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 13775238   402 RPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPS 440
Cdd:pfam06637 401 RPVGPVPNPPPIDPASLEEFKKRILESQRPPAGNPAASS 439
 
Name Accession Description Interval E-value
PV-1 pfam06637
PV-1 protein (PLVAP); This family consists of several PV-1 (PLVAP) proteins which seem to be ...
 2-440 0e+00

PV-1 protein (PLVAP); This family consists of several PV-1 (PLVAP) proteins which seem to be specific to mammals. PV-1 is a novel protein component of the endothelial fenestral and stomatal diaphragms. The function of this family is unknown.


Pssm-ID: 461970 [Multi-domain]  Cd Length: 439  Bit Score: 834.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238     2 GLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQ 81
Cdd:pfam06637   1 GLAMEHGGAYARAGGSPRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQVVGLTASQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238    82 SNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFML 161
Cdd:pfam06637  81 ANLSKELNLTARAKDAIMQMLLSARRDLDRINASFRQCQGDRVIYINNQRYMAAIILSEKQCQEQLKEANKSCDALLLML 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   162 NQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLW 241
Cdd:pfam06637 161 GQKAKTLEVELAKEKAVCTKDKESLLLSKRVAEEQLAECGKAREQQQQERQLAEDRLQKVQSLCLPLDKDKFETDLRNLW 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   242 RDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEA 321
Cdd:pfam06637 241 RDSIIPRTLDTLGYNLYHPLGSELASIRRTCDSLPSIMSTKVEELARSLRAGIERVARENSDLQRQKLEAEQSLRASQEA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   322 KQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVS 401
Cdd:pfam06637 321 KEKVEKEAQAREAKLQAECARQTQLALEEKAVLRKERDNLAKELEEKKREVEQLKMQLAVRNSALDTCIKAKSQPAIPLP 400

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 13775238   402 RPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPS 440
Cdd:pfam06637 401 RPVGPVPNPPPIDPASLEEFKKRILESQRPPAGNPAASS 439
PTZ00121 PTZ00121
MAEBL; Provisional
 140-382 3.41e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.84  E-value: 3.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   140 EKQCRDQFK----DMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVllNKRVAEE--QLVECVKTRELQHQERQL 213
Cdd:PTZ00121 1481 EAKKADEAKkkaeEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAE--EAKKADEakKAEEKKKADELKKAEELK 1558

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   214 AKEQLQKVQalclplDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEEL--ARSLR 291
Cdd:PTZ00121 1559 KAEEKKKAE------EAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELkkAEEEK 1632

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   292 ADIERVARENSDLQRQ-----KLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELE 366
Cdd:PTZ00121 1633 KKVEQLKKKEAEEKKKaeelkKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEA 1712

                         250
                  ....*....|....*.
gi 13775238   367 EKKREAEQLRMELAIR 382
Cdd:PTZ00121 1713 EEKKKAEELKKAEEEN 1728
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 281-376 3.13e-06

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 49.07  E-value: 3.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   281 SKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLA------LEEKAVL 354
Cdd:TIGR02794  71 KKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKAKQAAEAKAKAEaeaerkAKEEAAK 150

                          90       100
                  ....*....|....*....|..
gi 13775238   355 RKERDNLAKELEEKKREAEQLR 376
Cdd:TIGR02794 151 QAEEEAKAKAAAEAKKKAEEAK 172
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 171-387 7.24e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.39  E-value: 7.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238 171 EIAKEKTIctKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRnlwrdsiiprsL 250
Cdd:COG1196 217 ELKEELKE--LEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELE-----------L 283

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238 251 DNLGYNLYHpLGSELASIRRACDHmpslmsskVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQ 330
Cdd:COG1196 284 EEAQAEEYE-LLAELARLEQDIAR--------LEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELE 354

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 13775238 331 AREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALD 387
Cdd:COG1196 355 EAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEA 411
 
Name Accession Description Interval E-value
PV-1 pfam06637
PV-1 protein (PLVAP); This family consists of several PV-1 (PLVAP) proteins which seem to be ...
 2-440 0e+00

PV-1 protein (PLVAP); This family consists of several PV-1 (PLVAP) proteins which seem to be specific to mammals. PV-1 is a novel protein component of the endothelial fenestral and stomatal diaphragms. The function of this family is unknown.


Pssm-ID: 461970 [Multi-domain]  Cd Length: 439  Bit Score: 834.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238     2 GLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQ 81
Cdd:pfam06637   1 GLAMEHGGAYARAGGSPRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQVVGLTASQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238    82 SNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFML 161
Cdd:pfam06637  81 ANLSKELNLTARAKDAIMQMLLSARRDLDRINASFRQCQGDRVIYINNQRYMAAIILSEKQCQEQLKEANKSCDALLLML 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   162 NQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLW 241
Cdd:pfam06637 161 GQKAKTLEVELAKEKAVCTKDKESLLLSKRVAEEQLAECGKAREQQQQERQLAEDRLQKVQSLCLPLDKDKFETDLRNLW 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   242 RDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEA 321
Cdd:pfam06637 241 RDSIIPRTLDTLGYNLYHPLGSELASIRRTCDSLPSIMSTKVEELARSLRAGIERVARENSDLQRQKLEAEQSLRASQEA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   322 KQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVS 401
Cdd:pfam06637 321 KEKVEKEAQAREAKLQAECARQTQLALEEKAVLRKERDNLAKELEEKKREVEQLKMQLAVRNSALDTCIKAKSQPAIPLP 400

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 13775238   402 RPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPS 440
Cdd:pfam06637 401 RPVGPVPNPPPIDPASLEEFKKRILESQRPPAGNPAASS 439
PTZ00121 PTZ00121
MAEBL; Provisional
 140-382 3.41e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.84  E-value: 3.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   140 EKQCRDQFK----DMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVllNKRVAEE--QLVECVKTRELQHQERQL 213
Cdd:PTZ00121 1481 EAKKADEAKkkaeEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAE--EAKKADEakKAEEKKKADELKKAEELK 1558

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   214 AKEQLQKVQalclplDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEEL--ARSLR 291
Cdd:PTZ00121 1559 KAEEKKKAE------EAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELkkAEEEK 1632

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   292 ADIERVARENSDLQRQ-----KLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELE 366
Cdd:PTZ00121 1633 KKVEQLKKKEAEEKKKaeelkKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEA 1712

                         250
                  ....*....|....*.
gi 13775238   367 EKKREAEQLRMELAIR 382
Cdd:PTZ00121 1713 EEKKKAEELKKAEEEN 1728
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 281-376 3.13e-06

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 49.07  E-value: 3.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   281 SKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLA------LEEKAVL 354
Cdd:TIGR02794  71 KKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKAKQAAEAKAKAEaeaerkAKEEAAK 150

                          90       100
                  ....*....|....*....|..
gi 13775238   355 RKERDNLAKELEEKKREAEQLR 376
Cdd:TIGR02794 151 QAEEEAKAKAAAEAKKKAEEAK 172
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 171-387 7.24e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.39  E-value: 7.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238 171 EIAKEKTIctKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRnlwrdsiiprsL 250
Cdd:COG1196 217 ELKEELKE--LEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELE-----------L 283

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238 251 DNLGYNLYHpLGSELASIRRACDHmpslmsskVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQ 330
Cdd:COG1196 284 EEAQAEEYE-LLAELARLEQDIAR--------LEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELE 354

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 13775238 331 AREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALD 387
Cdd:COG1196 355 EAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEA 411
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 144-380 1.71e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.36  E-value: 1.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238    144 RDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQA 223
Cdd:TIGR02168  707 LEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEE 786

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238    224 LCLPLDKDKFEMDLrnlwrdsiIPRSLDNLGyNLYHPLGSELASIRRACDHMPSLMSSK------VEELARSLRADIERV 297
Cdd:TIGR02168  787 LEAQIEQLKEELKA--------LREALDELR-AELTLLNEEAANLRERLESLERRIAATerrledLEEQIEELSEDIESL 857

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238    298 ARENSDLQRQKLEAQQGLRASQEAKQKVekEAQAREAKLQAECSRQTQLALEEKAV-LRKERDNLAKELEEKKREAEQLR 376
Cdd:TIGR02168  858 AAEIEELEELIEELESELEALLNERASL--EEALALLRSELEELSEELRELESKRSeLRRELEELREKLAQLELRLEGLE 935


                   ....
gi 13775238    377 MELA 380
Cdd:TIGR02168  936 VRID 939
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
282-374 2.12e-04

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 43.32  E-value: 2.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238 282 KVEELARSLRADIERVARENSDLQRQKLEAQQglrasQEAKQKVEKEAQAREAKLQAEcsRQTQLALEekaVLRKERDNL 361
Cdd:COG2268 224 EEAELEQEREIETARIAEAEAELAKKKAEERR-----EAETARAEAEAAYEIAEANAE--REVQRQLE---IAEREREIE 293

                        90
                ....*....|...
gi 13775238 362 AKELEEKKREAEQ 374
Cdd:COG2268 294 LQEKEAEREEAEL 306
PTZ00121 PTZ00121
MAEBL; Provisional
 282-378 4.57e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 4.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   282 KVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVE----KEAQAREA----KLQAECSRQTQLALEEKAV 353
Cdd:PTZ00121 1648 KAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEalkkEAEEAKKAeelkKKEAEEKKKAEELKKAEEE 1727

                          90       100
                  ....*....|....*....|....*
gi 13775238   354 LRKERDNLAKELEEKKREAEQLRME 378
Cdd:PTZ00121 1728 NKIKAEEAKKEAEEDKKKAEEAKKD 1752
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 282-373 5.77e-04

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 42.10  E-value: 5.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238  282 KVEELARSLRadiERVAREnsdLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLaleEKAVLRKERDNL 361
Cdd:PRK09510  84 KEQQQAEELQ---QKQAAE---QERLKQLEKERLAAQEQKKQAEEAAKQAALKQKQAEEAAAKAA---AAAKAKAEAEAK 154

                         90
                 ....*....|..
gi 13775238  362 AKELEEKKREAE 373
Cdd:PRK09510 155 RAAAAAKKAAAE 166
PTZ00121 PTZ00121
MAEBL; Provisional
 282-376 7.33e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 7.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   282 KVEELARSLRAD------IERVARENSDLQRQKLEAQQgLRASQEAKQKVEKEAQAREAKLQAECSRQTQLA-------- 347
Cdd:PTZ00121 1392 KADEAKKKAEEDkkkadeLKKAAAAKKKADEAKKKAEE-KKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAkkkaeeak 1470

                          90       100       110
                  ....*....|....*....|....*....|...
gi 13775238   348 ----LEEKAVLRKERDNLAKELEEKKREAEQLR 376
Cdd:PTZ00121 1471 kadeAKKKAEEAKKADEAKKKAEEAKKKADEAK 1503
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
281-380 9.49e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 41.38  E-value: 9.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238 281 SKVEELARSLRADIERVARENSDLQRQKLEAqqglrasqeakqkvEKEAQAREAKLQAECSRQTQLALEEKAVLRKER-- 358
Cdd:COG2433 409 TEEEEEIRRLEEQVERLEAEVEELEAELEEK--------------DERIERLERELSEARSEERREIRKDREISRLDRei 474

                        90       100
                ....*....|....*....|..
gi 13775238 359 DNLAKELEEKKREAEQLRMELA 380
Cdd:COG2433 475 ERLERELEEERERIEELKRKLE 496
PTZ00121 PTZ00121
MAEBL; Provisional
 282-376 1.23e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   282 KVEELARslRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNL 361
Cdd:PTZ00121 1458 KAEEAKK--KAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKK 1535

                          90
                  ....*....|....*..
gi 13775238   362 AKELE--EKKREAEQLR 376
Cdd:PTZ00121 1536 ADEAKkaEEKKKADELK 1552
PTZ00121 PTZ00121
MAEBL; Provisional
 282-376 1.25e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   282 KVEELARSlrADIERVARENSDLQRQKLEAQQGlRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNL 361
Cdd:PTZ00121 1426 KAEEKKKA--DEAKKKAEEAKKADEAKKKAEEA-KKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEA 1502

                          90
                  ....*....|....*
gi 13775238   362 AKELEEKKReAEQLR 376
Cdd:PTZ00121 1503 KKAAEAKKK-ADEAK 1516
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 282-376 1.29e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.26  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   282 KVEELARslRADIERVARENSDLQRQKLEAQQGLRASQEAKQK----VEKEAQAREAKLQAEC-----------SRQTQL 346
Cdd:pfam17380 452 RLEEQER--QQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQrrkiLEKELEERKQAMIEEErkrkllekemeERQKAI 529

                          90       100       110
                  ....*....|....*....|....*....|
gi 13775238   347 ALEEKAVLRKERDNLAKELEEKKREAEQLR 376
Cdd:pfam17380 530 YEEERRREAEEERRKQQEMEERRRIQEQMR 559
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 155-430 1.33e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.21  E-value: 1.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238    155 DALLFMLNQKVKTLEVEI-AKEKTICTKDKESVLLNKRVAEEQlvecVKTRELQhQERQLAKEQLQKVQALC--LPLDKD 231
Cdd:TIGR02169  701 ENRLDELSQELSDASRKIgEIEKEIEQLEQEEEKLKERLEELE----EDLSSLE-QEIENVKSELKELEARIeeLEEDLH 775

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238    232 KFEMDLRNLwRDSIIPRSLDNLGyNLYHPLGSELASIRRACDHMPSLMSSK--VEELARSLRADIERVAREnSDLQRQKL 309
Cdd:TIGR02169  776 KLEEALNDL-EARLSHSRIPEIQ-AELSKLEEEVSRIEARLREIEQKLNRLtlEKEYLEKEIQELQEQRID-LKEQIKSI 852

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238    310 EAQQ-GLRASQEAKQKVEKEAQAREAKLQaecsrqtqlalEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDT 388
Cdd:TIGR02169  853 EKEIeNLNGKKEELEEELEELEAALRDLE-----------SRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSE 921

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 13775238    389 CIKTKSQPMMPVSRPMGPVPNPQPIDPA--SLEEFKRKILESQR 430
Cdd:TIGR02169  922 LKAKLEALEEELSEIEDPKGEDEEIPEEelSLEDVQAELQRVEE 965
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 281-374 1.56e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 40.60  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   281 SKVEELARSLRADIERVAREN----SDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAEcsrqtQLALEEKAVLRK 356
Cdd:TIGR02794  46 GAVAQQANRIQQQKKPAAKKEqerqKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAE-----QAAKQAEEKQKQ 120

                          90
                  ....*....|....*...
gi 13775238   357 ERDNLAKELEEKKREAEQ 374
Cdd:TIGR02794 121 AEEAKAKQAAEAKAKAEA 138
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 187-379 1.60e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.82  E-value: 1.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238    187 LLNKRVAEEQLVECvkTRELQHQERQLAK--EQLQKVQALCLPLDKDKFEMDLRnlwrdsiiprsLDNLGYNLYHPLGSE 264
Cdd:TIGR02169  229 LKEKEALERQKEAI--ERQLASLEEELEKltEEISELEKRLEEIEQLLEELNKK-----------IKDLGEEEQLRVKEK 295

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238    265 LASI---RRACDHMPSLMSSKVEELARSLR---ADIERVARENSDLQRQkLEAQQGLRAsqeakqKVEKEAQAREAKLQA 338
Cdd:TIGR02169  296 IGELeaeIASLERSIAEKERELEDAEERLAkleAEIDKLLAEIEELERE-IEEERKRRD------KLTEEYAELKEELED 368

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 13775238    339 ECSRQTQLAlEEKAVLRKERDNLAKELEEKKREAEQLRMEL 379
Cdd:TIGR02169  369 LRAELEEVD-KEFAETRDELKDYREKLEKLKREINELKREL 408
PTZ00121 PTZ00121
MAEBL; Provisional
 308-376 1.77e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 1.77e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13775238   308 KLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKReAEQLR 376
Cdd:PTZ00121 1370 EKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKK-ADEAK 1437
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 263-387 1.88e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 39.52  E-value: 1.88e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238 263 SELASIRRACDHMPSLMSSKVEELARsLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVE---------KEAQARE 333
Cdd:COG1579  17 SELDRLEHRLKELPAELAELEDELAA-LEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEeqlgnvrnnKEYEALQ 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238 334 AKLQAECSRQTQL------ALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALD 387
Cdd:COG1579  96 KEIESLKRRISDLedeileLMERIEELEEELAELEAELAELEAELEEKKAELDEELAELE 155
PTZ00121 PTZ00121
MAEBL; Provisional
 282-376 2.20e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 2.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   282 KVEELARSlrADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQlALEEKAVLRKERDNL 361
Cdd:PTZ00121 1386 KAEEKKKA--DEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKAD-EAKKKAEEAKKAEEA 1462

                          90
                  ....*....|....*
gi 13775238   362 AKELEEKKReAEQLR 376
Cdd:PTZ00121 1463 KKKAEEAKK-ADEAK 1476
PTZ00121 PTZ00121
MAEBL; Provisional
 282-371 2.29e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   282 KVEElARslRADIERVARENSdlQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNL 361
Cdd:PTZ00121 1273 KAEE-AR--KADELKKAEEKK--KADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEA 1347

                          90
                  ....*....|
gi 13775238   362 AKELEEKKRE 371
Cdd:PTZ00121 1348 AKAEAEAAAD 1357
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 305-378 2.62e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.11  E-value: 2.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   305 QRQKLEAQQGLRASQEAKQK---VEKEAQAREAKL--QAECSRQTQL-ALEEKAVLRKERDNLAKELEEKKREAEQLRME 378
Cdd:pfam17380 289 QQEKFEKMEQERLRQEKEEKareVERRRKLEEAEKarQAEMDRQAAIyAEQERMAMERERELERIRQEERKRELERIRQE 368
PTZ00121 PTZ00121
MAEBL; Provisional
 282-385 3.18e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 3.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   282 KVEEL---------ARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQARE-----AKLQAECSRQTQLA 347
Cdd:PTZ00121 1303 KADEAkkkaeeakkADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEekaeaAEKKKEEAKKKADA 1382

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 13775238   348 LEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSA 385
Cdd:PTZ00121 1383 AKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKA 1420
PTZ00121 PTZ00121
MAEBL; Provisional
 282-376 3.26e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 3.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   282 KVEELARSlrADIERVARENSDLQRQKLEAQQGlRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNL 361
Cdd:PTZ00121 1439 KAEEAKKA--DEAKKKAEEAKKAEEAKKKAEEA-KKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEA 1515

                          90
                  ....*....|....*
gi 13775238   362 AKelEEKKREAEQLR 376
Cdd:PTZ00121 1516 KK--AEEAKKADEAK 1528
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 284-372 4.72e-03

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 39.55  E-value: 4.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   284 EELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAecsrqtqlALEEKAVLRKERDNLAK 363
Cdd:PRK11448  141 ENLLHALQQEVLTLKQQLELQAREKAQSQALAEAQQQELVALEGLAAELEEKQQE--------LEAQLEQLQEKAAETSQ 212


                  ....*....
gi 13775238   364 ELEEKKREA 372
Cdd:PRK11448  213 ERKQKRKEI 221
PRK09173 PRK09173
F0F1 ATP synthase subunit B; Validated
 286-390 4.74e-03

F0F1 ATP synthase subunit B; Validated


Pssm-ID: 169691 [Multi-domain]  Cd Length: 159  Bit Score: 37.80  E-value: 4.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238  286 LARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQA------REAK-LQAECSRQTqlaleEKAVLRkeR 358
Cdd:PRK09173  27 IARSLDARADRIKNELAEARRLREEAQQLLAEYQRKRKEAEKEAADivaaaeREAEaLTAEAKRKT-----EEYVAR--R 99

                         90       100       110
                 ....*....|....*....|....*....|..
gi 13775238  359 DNLAkelEEKKREAEQLRMElAIRNSALDTCI 390
Cdd:PRK09173 100 NKLA---EQKIAQAETDAIN-AVRSSAVDLAI 127
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 285-380 5.65e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 39.16  E-value: 5.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   285 ELARSLRADIERVAR---ENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEekavlRKERDNL 361
Cdd:pfam15709 369 ERAEKMREELELEQQrrfEEIRLRKQRLEEERQRQEEEERKQRLQLQAAQERARQQQEEFRRKLQELQ-----RKKQQEE 443

                          90
                  ....*....|....*....
gi 13775238   362 AKELEEKKREAEQLRMELA 380
Cdd:pfam15709 444 AERAEAEKQRQKELEMQLA 462
TolA COG3064
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
282-376 6.35e-03

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442298 [Multi-domain]  Cd Length: 485  Bit Score: 38.87  E-value: 6.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238 282 KVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLAleEKAVLRKERDnL 361
Cdd:COG3064  17 RLEQAEAEKRAAAEAEQKAKEEAEEERLAELEAKRQAEEEAREAKAEAEQRAAELAAEAAKKLAEA--EKAAAEAEKK-A 93

                        90
                ....*....|....*
gi 13775238 362 AKELEEKKREAEQLR 376
Cdd:COG3064  94 AAEKAKAAKEAEAAA 108
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 175-387 6.68e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 38.87  E-value: 6.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238    175 EKTICTKDKESVLLNKRVAE-EQLVECVKTRELQHQERQLAKEQLqkVQALCLPLDKDKFEmdlrnlwRDSIIPRSLDNL 253
Cdd:TIGR00606  325 QRELEKLNKERRLLNQEKTElLVEQGRLQLQADRHQEHIRARDSL--IQSLATRLELDGFE-------RGPFSERQIKNF 395

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238    254 GYNLYHPLGSELASIRRACDHMPSLMSSKVEE----------LARSLRADIERVARENSDLQRQKLEAQQGLRAS----- 318
Cdd:TIGR00606  396 HTLVIERQEDEAKTAAQLCADLQSKERLKQEQadeirdekkgLGRTIELKKEILEKKQEELKFVIKELQQLEGSSdrile 475

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13775238    319 -QEAKQKVEKEAQAREAKLQAECSRQTQLALE-EKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALD 387
Cdd:TIGR00606  476 lDQELRKAERELSKAEKNSLTETLKKEVKSLQnEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMD 546
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 287-374 7.83e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 38.29  E-value: 7.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775238   287 ARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAEcsRQTQLALEEKAVLRKER------DN 360
Cdd:TIGR02794  63 AKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAE--EKQKQAEEAKAKQAAEAkakaeaEA 140

                          90
                  ....*....|....
gi 13775238   361 LAKELEEKKREAEQ 374
Cdd:TIGR02794 141 ERKAKEEAAKQAEE 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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