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Conserved domains on  [gi|298493214|ref|NP_113753|]
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carboxylesterase 1E precursor [Rattus norvegicus]

Protein Classification

carboxylesterase/lipase family protein( domain architecture ID 10444481)

carboxylesterase/lipase family protein similar to carboxylesterase, which catalyzes the hydrolysis of a carboxylic ester to form an alcohol and a carboxylate, and lipase, which hydrolyzes triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids

CATH:  3.40.50.1820
EC:  3.1.1.-
PubMed:  8453375|3163407|8280778|9704093|11099800
SCOP:  3000102

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
24-545 0e+00

Carboxylesterase family;


:

Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 627.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214   24 PVVDTLQGKVLGKYVSLEGfTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDPVAGQivndlltn 103
Cdd:pfam00135   3 PVVTTSLGRVRGKRLKVDG-GKPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTS-------- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  104 rEENISLQFSEDCLYLNIYTPADLTKRD-RLPVMVWIHGGGLVLGGASTYDGLALSTHENVVVVVIQYRLGIWGFFSTGD 182
Cdd:pfam00135  74 -PGSSGLEGSEDCLYLNVYTPKELKENKnKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLSTGD 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  183 EHSRGNWGHLDQVAALHWVQDNIDNFGGDPGSVTIFGESAGGESVSVLVLSPLAKNLFHKAISESGVALTAGLVKKNTRP 262
Cdd:pfam00135 153 DEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNARQ 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  263 LAEKIAVVSGCKSTTSAAMVHCLRQKTEEELLETTLKLnlfsldLHGDSRQSYPFVPTVlDGVVLPKMPEEILAEKDFNT 342
Cdd:pfam00135 233 RAKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKL------LVYGSVPFVPFGPVV-DGDFLPEHPEELLKSGNFPK 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  343 VPYIVGINKQEFGWILPTMMNYPPSDMKLDPMTATSLLKKSSFLLN--LPEEAIPVAVEKYLR--HTDDPDRNKDQLLEL 418
Cdd:pfam00135 306 VPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLvdLPEEISAALREEYLDwgDRDDPETSRRALVEL 385

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  419 IGDVIFGVPSVIVSRGHRDAGARTYMYEFQYRPSFSskMKPSTVVGDHGDEIYSVFGAPILRGGT-SKEEINLSKMMMKF 497
Cdd:pfam00135 386 LTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSL--RYPKWVGVDHGDELPYVFGTPFVGALLfTEEDEKLSRKMMTY 463

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 298493214  498 WANFARNGNPNGQ-GLPHWPEY-DQKEGYLQIGATTQQAQKLKEKEVAFW 545
Cdd:pfam00135 464 WTNFAKTGNPNGPeGLPKWPPYtDENGQYLSIDLEPRVKQGLKAERCAFW 513
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
24-545 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 627.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214   24 PVVDTLQGKVLGKYVSLEGfTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDPVAGQivndlltn 103
Cdd:pfam00135   3 PVVTTSLGRVRGKRLKVDG-GKPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTS-------- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  104 rEENISLQFSEDCLYLNIYTPADLTKRD-RLPVMVWIHGGGLVLGGASTYDGLALSTHENVVVVVIQYRLGIWGFFSTGD 182
Cdd:pfam00135  74 -PGSSGLEGSEDCLYLNVYTPKELKENKnKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLSTGD 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  183 EHSRGNWGHLDQVAALHWVQDNIDNFGGDPGSVTIFGESAGGESVSVLVLSPLAKNLFHKAISESGVALTAGLVKKNTRP 262
Cdd:pfam00135 153 DEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNARQ 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  263 LAEKIAVVSGCKSTTSAAMVHCLRQKTEEELLETTLKLnlfsldLHGDSRQSYPFVPTVlDGVVLPKMPEEILAEKDFNT 342
Cdd:pfam00135 233 RAKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKL------LVYGSVPFVPFGPVV-DGDFLPEHPEELLKSGNFPK 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  343 VPYIVGINKQEFGWILPTMMNYPPSDMKLDPMTATSLLKKSSFLLN--LPEEAIPVAVEKYLR--HTDDPDRNKDQLLEL 418
Cdd:pfam00135 306 VPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLvdLPEEISAALREEYLDwgDRDDPETSRRALVEL 385

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  419 IGDVIFGVPSVIVSRGHRDAGARTYMYEFQYRPSFSskMKPSTVVGDHGDEIYSVFGAPILRGGT-SKEEINLSKMMMKF 497
Cdd:pfam00135 386 LTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSL--RYPKWVGVDHGDELPYVFGTPFVGALLfTEEDEKLSRKMMTY 463

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 298493214  498 WANFARNGNPNGQ-GLPHWPEY-DQKEGYLQIGATTQQAQKLKEKEVAFW 545
Cdd:pfam00135 464 WTNFAKTGNPNGPeGLPKWPPYtDENGQYLSIDLEPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 25-536 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 574.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  25 VVDTLQGKVLGKYVSlegftqPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDpvagqivnDLLTNR 104
Cdd:cd00312    1 LVVTPNGKVRGVDEG------GVYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQW--------DQLGGG 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 105 EENISLQFSEDCLYLNIYTPADLTKRDRLPVMVWIHGGGLVLGGASTYDGLALS-THENVVVVVIQYRLGIWGFFSTGDE 183
Cdd:cd00312   67 LWNAKLPGSEDCLYLNVYTPKNTKPGNSLPVMVWIHGGGFMFGSGSLYPGDGLArEGDNVIVVSINYRLGVLGFLSTGDI 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 184 HSRGNWGHLDQVAALHWVQDNIDNFGGDPGSVTIFGESAGGESVSVLVLSPLAKNLFHKAISESGVALTAGLVKKNTRPL 263
Cdd:cd00312  147 ELPGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQENARGR 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 264 AEKIAVVSGCKSTTSAAMVHCLRQKTEEELLETTLKLNLFSLDLhgdsrqSYPFVPtVLDGVVLPKMPEEILAEKDFNTV 343
Cdd:cd00312  227 AKRLARLLGCNDTSSAELLDCLRSKSAEELLDATRKLLLFSYSP------FLPFGP-VVDGDFIPDDPEELIKEGKFAKV 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 344 PYIVGINKQEFGWILPTMMNYPPSDMKLdpmTATSLLKKSSFLLN-LPEEAIPVAVEKYLRHTDDPDRNKDQLLELIGDV 422
Cdd:cd00312  300 PLIIGVTKDEGGYFAAMLLNFDAKLIIE---TNDRWLELLPYLLFyADDALADKVLEKYPGDVDDSVESRKNLSDMLTDL 376

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 423 IFGVPSVIVSRGHRDA-GARTYMYEFQYRPSFSSKMKPSTVVGDHGDEIYSVFGAPILRGGTSKEEINLSKMMMKFWANF 501
Cdd:cd00312  377 LFKCPARYFLAQHRKAgGSPVYAYVFDHRSSLSVGRWPPWLGTVHGDEIFFVFGNPLLKEGLREEEEKLSRTMMKYWANF 456

                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 298493214 502 ARNGNPNG-QGLPHWPEYD-QKEGYLQIGATTQQAQK 536
Cdd:cd00312  457 AKTGNPNTeGNLVVWPAYTsESEKYLDINIEGTEIKQ 493
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
16-548 1.03e-147

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 434.32  E-value: 1.03e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  16 AGGHPSSLPVVDTLQGKVLGkyVSLEGftqpVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDPVAGQ 95
Cdd:COG2272    5 LAAAAAAAPVVRTEAGRVRG--VVEGG----VRVFLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPPRPGD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  96 IVNdlltnreeniSLQFSEDCLYLNIYTPADLTKRdRLPVMVWIHGGGLVLGGAST--YDGLALSThENVVVVVIQYRLG 173
Cdd:COG2272   79 PGG----------PAPGSEDCLYLNVWTPALAAGA-KLPVMVWIHGGGFVSGSGSEplYDGAALAR-RGVVVVTINYRLG 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 174 IWGFF-----STGDEHSRGNWGHLDQVAALHWVQDNIDNFGGDPGSVTIFGESAGGESVSVLVLSPLAKNLFHKAISESG 248
Cdd:COG2272  147 ALGFLalpalSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSG 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 249 VALTAglvkkNTRPLAEKIAV----VSGCKSTTSAamvhCLRQKTEEELLETtlklnlfSLDLHGDSRQSYPFVPtVLDG 324
Cdd:COG2272  227 AGLSV-----LTLAEAEAVGAafaaALGVAPATLA----ALRALPAEELLAA-------QAALAAEGPGGLPFGP-VVDG 289

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 325 VVLPKMPEEILAEKDFNTVPYIVGINKQEFGWilptmmnYPPSDMKLDPMTATSLLKKssfLLNLPEEAIPVAVEKYlrh 404
Cdd:COG2272  290 DVLPEDPLEAFAAGRAADVPLLIGTNRDEGRL-------FAALLGDLGPLTAADYRAA---LRRRFGDDADEVLAAY--- 356

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 405 tdDPDRNKDQLLELIGDVIFGVPSVIVSRGHRDAGARTYMYEFQYRPSFSSKMKPSTVvgdHGDEIYSVFG---APILRG 481
Cdd:COG2272  357 --PAASPAEALAALATDRVFRCPARRLAEAHAAAGAPVYLYRFDWRSPPLRGFGLGAF---HGAELPFVFGnldAPALTG 431

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 298493214 482 GTsKEEINLSKMMMKFWANFARNGNPNGQGLPHWPEYDQKEG-YLQIGATTQQAQKLKEKE-VAFWSEL 548
Cdd:COG2272  432 LT-PADRALSDQMQAYWVNFARTGDPNGPGLPEWPAYDPEDRaVMVFDAEPRVVNDPDAEErLDLWDGV 499
PRK10162 PRK10162
acetyl esterase;
135-223 2.75e-03

acetyl esterase;


Pssm-ID: 236660 [Multi-domain]  Cd Length: 318  Bit Score: 40.09  E-value: 2.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 135 VMVWIHGGGLVLGGASTYDGLA--LSTHENVVVVVIQYRLGIWGFFSTGDEHSrgnwghldqVAALHWVQDNIDNFGGDP 212
Cdd:PRK10162  83 TLFYLHGGGFILGNLDTHDRIMrlLASYSGCTVIGIDYTLSPEARFPQAIEEI---------VAVCCYFHQHAEDYGINM 153

                         90
                 ....*....|.
gi 298493214 213 GSVTIFGESAG 223
Cdd:PRK10162 154 SRIGFAGDSAG 164
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
24-545 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 627.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214   24 PVVDTLQGKVLGKYVSLEGfTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDPVAGQivndlltn 103
Cdd:pfam00135   3 PVVTTSLGRVRGKRLKVDG-GKPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTS-------- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  104 rEENISLQFSEDCLYLNIYTPADLTKRD-RLPVMVWIHGGGLVLGGASTYDGLALSTHENVVVVVIQYRLGIWGFFSTGD 182
Cdd:pfam00135  74 -PGSSGLEGSEDCLYLNVYTPKELKENKnKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLSTGD 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  183 EHSRGNWGHLDQVAALHWVQDNIDNFGGDPGSVTIFGESAGGESVSVLVLSPLAKNLFHKAISESGVALTAGLVKKNTRP 262
Cdd:pfam00135 153 DEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNARQ 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  263 LAEKIAVVSGCKSTTSAAMVHCLRQKTEEELLETTLKLnlfsldLHGDSRQSYPFVPTVlDGVVLPKMPEEILAEKDFNT 342
Cdd:pfam00135 233 RAKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKL------LVYGSVPFVPFGPVV-DGDFLPEHPEELLKSGNFPK 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  343 VPYIVGINKQEFGWILPTMMNYPPSDMKLDPMTATSLLKKSSFLLN--LPEEAIPVAVEKYLR--HTDDPDRNKDQLLEL 418
Cdd:pfam00135 306 VPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLvdLPEEISAALREEYLDwgDRDDPETSRRALVEL 385

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  419 IGDVIFGVPSVIVSRGHRDAGARTYMYEFQYRPSFSskMKPSTVVGDHGDEIYSVFGAPILRGGT-SKEEINLSKMMMKF 497
Cdd:pfam00135 386 LTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSL--RYPKWVGVDHGDELPYVFGTPFVGALLfTEEDEKLSRKMMTY 463

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 298493214  498 WANFARNGNPNGQ-GLPHWPEY-DQKEGYLQIGATTQQAQKLKEKEVAFW 545
Cdd:pfam00135 464 WTNFAKTGNPNGPeGLPKWPPYtDENGQYLSIDLEPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 25-536 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 574.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  25 VVDTLQGKVLGKYVSlegftqPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDpvagqivnDLLTNR 104
Cdd:cd00312    1 LVVTPNGKVRGVDEG------GVYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQW--------DQLGGG 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 105 EENISLQFSEDCLYLNIYTPADLTKRDRLPVMVWIHGGGLVLGGASTYDGLALS-THENVVVVVIQYRLGIWGFFSTGDE 183
Cdd:cd00312   67 LWNAKLPGSEDCLYLNVYTPKNTKPGNSLPVMVWIHGGGFMFGSGSLYPGDGLArEGDNVIVVSINYRLGVLGFLSTGDI 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 184 HSRGNWGHLDQVAALHWVQDNIDNFGGDPGSVTIFGESAGGESVSVLVLSPLAKNLFHKAISESGVALTAGLVKKNTRPL 263
Cdd:cd00312  147 ELPGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQENARGR 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 264 AEKIAVVSGCKSTTSAAMVHCLRQKTEEELLETTLKLNLFSLDLhgdsrqSYPFVPtVLDGVVLPKMPEEILAEKDFNTV 343
Cdd:cd00312  227 AKRLARLLGCNDTSSAELLDCLRSKSAEELLDATRKLLLFSYSP------FLPFGP-VVDGDFIPDDPEELIKEGKFAKV 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 344 PYIVGINKQEFGWILPTMMNYPPSDMKLdpmTATSLLKKSSFLLN-LPEEAIPVAVEKYLRHTDDPDRNKDQLLELIGDV 422
Cdd:cd00312  300 PLIIGVTKDEGGYFAAMLLNFDAKLIIE---TNDRWLELLPYLLFyADDALADKVLEKYPGDVDDSVESRKNLSDMLTDL 376

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 423 IFGVPSVIVSRGHRDA-GARTYMYEFQYRPSFSSKMKPSTVVGDHGDEIYSVFGAPILRGGTSKEEINLSKMMMKFWANF 501
Cdd:cd00312  377 LFKCPARYFLAQHRKAgGSPVYAYVFDHRSSLSVGRWPPWLGTVHGDEIFFVFGNPLLKEGLREEEEKLSRTMMKYWANF 456

                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 298493214 502 ARNGNPNG-QGLPHWPEYD-QKEGYLQIGATTQQAQK 536
Cdd:cd00312  457 AKTGNPNTeGNLVVWPAYTsESEKYLDINIEGTEIKQ 493
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
16-548 1.03e-147

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 434.32  E-value: 1.03e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  16 AGGHPSSLPVVDTLQGKVLGkyVSLEGftqpVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDPVAGQ 95
Cdd:COG2272    5 LAAAAAAAPVVRTEAGRVRG--VVEGG----VRVFLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPPRPGD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  96 IVNdlltnreeniSLQFSEDCLYLNIYTPADLTKRdRLPVMVWIHGGGLVLGGAST--YDGLALSThENVVVVVIQYRLG 173
Cdd:COG2272   79 PGG----------PAPGSEDCLYLNVWTPALAAGA-KLPVMVWIHGGGFVSGSGSEplYDGAALAR-RGVVVVTINYRLG 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 174 IWGFF-----STGDEHSRGNWGHLDQVAALHWVQDNIDNFGGDPGSVTIFGESAGGESVSVLVLSPLAKNLFHKAISESG 248
Cdd:COG2272  147 ALGFLalpalSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSG 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 249 VALTAglvkkNTRPLAEKIAV----VSGCKSTTSAamvhCLRQKTEEELLETtlklnlfSLDLHGDSRQSYPFVPtVLDG 324
Cdd:COG2272  227 AGLSV-----LTLAEAEAVGAafaaALGVAPATLA----ALRALPAEELLAA-------QAALAAEGPGGLPFGP-VVDG 289

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 325 VVLPKMPEEILAEKDFNTVPYIVGINKQEFGWilptmmnYPPSDMKLDPMTATSLLKKssfLLNLPEEAIPVAVEKYlrh 404
Cdd:COG2272  290 DVLPEDPLEAFAAGRAADVPLLIGTNRDEGRL-------FAALLGDLGPLTAADYRAA---LRRRFGDDADEVLAAY--- 356

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 405 tdDPDRNKDQLLELIGDVIFGVPSVIVSRGHRDAGARTYMYEFQYRPSFSSKMKPSTVvgdHGDEIYSVFG---APILRG 481
Cdd:COG2272  357 --PAASPAEALAALATDRVFRCPARRLAEAHAAAGAPVYLYRFDWRSPPLRGFGLGAF---HGAELPFVFGnldAPALTG 431

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 298493214 482 GTsKEEINLSKMMMKFWANFARNGNPNGQGLPHWPEYDQKEG-YLQIGATTQQAQKLKEKE-VAFWSEL 548
Cdd:COG2272  432 LT-PADRALSDQMQAYWVNFARTGDPNGPGLPEWPAYDPEDRaVMVFDAEPRVVNDPDAEErLDLWDGV 499
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
121-224 1.84e-19

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 86.85  E-value: 1.84e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 121 IYTPADLTkrDRLPVMVWIHGGGLVLGGASTYDGLA--LSTHENVVVVVIQYRLGiwgffstgDEHSrgnW-GHLDQV-A 196
Cdd:COG0657    3 VYRPAGAK--GPLPVVVYFHGGGWVSGSKDTHDPLArrLAARAGAAVVSVDYRLA--------PEHP---FpAALEDAyA 69

                         90       100
                 ....*....|....*....|....*...
gi 298493214 197 ALHWVQDNIDNFGGDPGSVTIFGESAGG 224
Cdd:COG0657   70 ALRWLRANAAELGIDPDRIAVAGDSAGG 97
Abhydrolase_3 pfam07859
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 136-224 4.31e-14

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 400284 [Multi-domain]  Cd Length: 208  Bit Score: 71.47  E-value: 4.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  136 MVWIHGGGLVLGGASTYDGLA--LSTHENVVVVVIQYRLgiwgffstGDEHSrgnW--GHLDQVAALHWVQDNIDNFGGD 211
Cdd:pfam07859   1 LVYFHGGGFVLGSADTHDRLCrrLAAEAGAVVVSVDYRL--------APEHP---FpaAYDDAYAALRWLAEQAAELGAD 69

                          90
                  ....*....|...
gi 298493214  212 PGSVTIFGESAGG 224
Cdd:pfam07859  70 PSRIAVAGDSAGG 82
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
121-250 1.16e-08

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 55.79  E-value: 1.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 121 IYTPADLTKRdrlPVMVWIHGGGLVLGGASTYDGLALsTHENVVVVVIQYRlgiwgffstGDEHSRGNWGHL---DQVAA 197
Cdd:COG1506   14 LYLPADGKKY---PVVVYVHGGPGSRDDSFLPLAQAL-ASRGYAVLAPDYR---------GYGESAGDWGGDevdDVLAA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 298493214 198 LHWVqdnIDNFGGDPGSVTIFGESAGGesVSVLVLSPLAKNLFHKAISESGVA 250
Cdd:COG1506   81 IDYL---AARPYVDPDRIGIYGHSYGG--YMALLAAARHPDRFKAAVALAGVS 128
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
 119-224 1.15e-06

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 49.49  E-value: 1.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  119 LNIYTPADLTKRdrLPVMVWIHGGGLVLGGASTYDGLALSTHENV-----VVVVIQYRLgiwgffsTGDEHSRgnwghlD 193
Cdd:pfam20434   1 LDIYLPKNAKGP--YPVVIWIHGGGWNSGDKEADMGFMTNTVKALlkagyAVASINYRL-------STDAKFP------A 65

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 298493214  194 QV----AALHWVQDNIDNFGGDPGSVTIFGESAGG 224
Cdd:pfam20434  66 QIqdvkAAIRFLRANAAKYGIDTNKIALMGFSAGG 100
COG4099 COG4099
Predicted peptidase [General function prediction only];
93-224 2.24e-04

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 43.03  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  93 AGQIVNDLLTNREENISLQFsedclylNIYTPADLTKRDRLPVMVWIHGGG-------LVLG-GASTYDGLALSTHENVV 164
Cdd:COG4099   16 QDGFEARTFTDPSDGDTLPY-------RLYLPKGYDPGKKYPLVLFLHGAGergtdneKQLThGAPKFINPENQAKFPAI 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 298493214 165 VVVIQYRLGIWgffstgdehsrgnWGHLDQVAALH-WVQDNIDNFGGDPGSVTIFGESAGG 224
Cdd:COG4099   89 VLAPQCPEDDY-------------WSDTKALDAVLaLLDDLIAEYRIDPDRIYLTGLSMGG 136
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 121-224 8.89e-04

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 41.53  E-value: 8.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 121 IYTPADLTKRDRLPVMVWIHGGGlvlGGASTYD---GL-ALSTHENVVVV----VIQYRLGIWGFFSTGDEHSRGnwGHL 192
Cdd:COG3509   41 LYVPAGYDGGAPLPLVVALHGCG---GSAADFAagtGLnALADREGFIVVypegTGRAPGRCWNWFDGRDQRRGR--DDV 115

                         90       100       110
                 ....*....|....*....|....*....|..
gi 298493214 193 DQVAALhwVQDNIDNFGGDPGSVTIFGESAGG 224
Cdd:COG3509  116 AFIAAL--VDDLAARYGIDPKRVYVTGLSAGG 145
PRK10162 PRK10162
acetyl esterase;
135-223 2.75e-03

acetyl esterase;


Pssm-ID: 236660 [Multi-domain]  Cd Length: 318  Bit Score: 40.09  E-value: 2.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214 135 VMVWIHGGGLVLGGASTYDGLA--LSTHENVVVVVIQYRLGIWGFFSTGDEHSrgnwghldqVAALHWVQDNIDNFGGDP 212
Cdd:PRK10162  83 TLFYLHGGGFILGNLDTHDRIMrlLASYSGCTVIGIDYTLSPEARFPQAIEEI---------VAVCCYFHQHAEDYGINM 153

                         90
                 ....*....|.
gi 298493214 213 GSVTIFGESAG 223
Cdd:PRK10162 154 SRIGFAGDSAG 164
Esterase pfam00756
Putative esterase; This family contains Esterase D. However it is not clear if all members of ...
 119-248 4.46e-03

Putative esterase; This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.


Pssm-ID: 395613 [Multi-domain]  Cd Length: 246  Bit Score: 38.98  E-value: 4.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298493214  119 LNIYTPADLTKRDRLPVMVWIHGGGLV-LGGA-STYDGLALSTHENVVVVViqyrlgiwgFFSTGDEHSR-GNWGHLDQV 195
Cdd:pfam00756  10 VQVYLPEDYPPGRKYPVLYLLDGTGWFqNGPAkEGLDRLAASGEIPPVIIV---------GSPRGGEVSFySDWDRGLNA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 298493214  196 AALHWVQDNID------------NFGGDPGSVTIFGESAGGesVSVLVLSPLAKNLFHKAISESG 248
Cdd:pfam00756  81 TEGPGAYAYETfltqelpplldaNFPTAPDGRALAGQSMGG--LGALYLALKYPDLFGSVSSFSP 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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