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Conserved domains on  [gi|1937896878|ref|NP_113887|]
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claudin-1 [Rattus norvegicus]

Protein Classification

PMP-22/EMP/MP20 family protein( domain architecture ID 10467089)

PMP-22/EMP/MP20 family tetraspan membrane protein similar to human claudin-9 (hCLDN-9) which is highly expressed in the inner ear, essential for hearing and a high-affinity receptor of CpE

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
5-182 2.99e-51

PMP-22/EMP/MP20/Claudin family;


:

Pssm-ID: 395662  Cd Length: 162  Bit Score: 162.93  E-value: 2.99e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937896878   5 GLQLLGFILASLGWIGSIVSTALP-QWKIYSYAGdnivtaQAIYEGLWMSCVSQS-TGQIQCKVFdsllNLNSTLQATRA 82
Cdd:pfam00822   2 LVLLLGFIVSHIAWVILLFVATIPdQWKVSRYVG------AAASAGLWRNCTTQScTGQISCKVL----ELNDALQAVQA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937896878  83 LMVIGILLGLIAIFVSTIGMKCMRCLEDDEVqkmwmaviGGIIFVISGLATLVATAWYGNRIVQEFYDPMTPvNARYEFG 162
Cdd:pfam00822  72 LMILSIILGIISLIVFFFQLFTMRKGGRFKL--------AGIIFLVSGLCVLVGASIYTSRIATDFGNPFTP-NRKYSFG 142

                         170       180
                  ....*....|....*....|
gi 1937896878 163 QALFTGWAAASLCLLGGALL 182
Cdd:pfam00822 143 YSFILGWVAFALAFIGGVLY 162
 
Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
5-182 2.99e-51

PMP-22/EMP/MP20/Claudin family;


Pssm-ID: 395662  Cd Length: 162  Bit Score: 162.93  E-value: 2.99e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937896878   5 GLQLLGFILASLGWIGSIVSTALP-QWKIYSYAGdnivtaQAIYEGLWMSCVSQS-TGQIQCKVFdsllNLNSTLQATRA 82
Cdd:pfam00822   2 LVLLLGFIVSHIAWVILLFVATIPdQWKVSRYVG------AAASAGLWRNCTTQScTGQISCKVL----ELNDALQAVQA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937896878  83 LMVIGILLGLIAIFVSTIGMKCMRCLEDDEVqkmwmaviGGIIFVISGLATLVATAWYGNRIVQEFYDPMTPvNARYEFG 162
Cdd:pfam00822  72 LMILSIILGIISLIVFFFQLFTMRKGGRFKL--------AGIIFLVSGLCVLVGASIYTSRIATDFGNPFTP-NRKYSFG 142

                         170       180
                  ....*....|....*....|
gi 1937896878 163 QALFTGWAAASLCLLGGALL 182
Cdd:pfam00822 143 YSFILGWVAFALAFIGGVLY 162
 
Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
5-182 2.99e-51

PMP-22/EMP/MP20/Claudin family;


Pssm-ID: 395662  Cd Length: 162  Bit Score: 162.93  E-value: 2.99e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937896878   5 GLQLLGFILASLGWIGSIVSTALP-QWKIYSYAGdnivtaQAIYEGLWMSCVSQS-TGQIQCKVFdsllNLNSTLQATRA 82
Cdd:pfam00822   2 LVLLLGFIVSHIAWVILLFVATIPdQWKVSRYVG------AAASAGLWRNCTTQScTGQISCKVL----ELNDALQAVQA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937896878  83 LMVIGILLGLIAIFVSTIGMKCMRCLEDDEVqkmwmaviGGIIFVISGLATLVATAWYGNRIVQEFYDPMTPvNARYEFG 162
Cdd:pfam00822  72 LMILSIILGIISLIVFFFQLFTMRKGGRFKL--------AGIIFLVSGLCVLVGASIYTSRIATDFGNPFTP-NRKYSFG 142

                         170       180
                  ....*....|....*....|
gi 1937896878 163 QALFTGWAAASLCLLGGALL 182
Cdd:pfam00822 143 YSFILGWVAFALAFIGGVLY 162
Claudin_2 pfam13903
PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight ...
 16-183 1.06e-05

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight junctions between cells.


Pssm-ID: 372799 [Multi-domain]  Cd Length: 191  Bit Score: 44.34  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937896878  16 LGWIGSIVSTALPQWKIYSYAGDNIVTAQAI--YEGLWMSC--------------VSQSTGQIQCKVFDSLLNLNSTLQA 79
Cdd:pfam13903   2 LAFALLLIAFATDYWLVLDVALTGINNYTCLfaHLGLWRHCfksevdvdsdnqtrFFGCLNQVPNPFPTFEEEIVSFSVT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937896878  80 TR-ALMVIGILLGLIAIFVSTIGMKCMRCLEDDEVQKMWMAviGGIIFVISGLATLVATAWY---GNRIVQEFYDPMTPV 155
Cdd:pfam13903  82 SLpGLTRFVQAFAILSLVLIVCGVVCGLLALPKQSVFLLLA--AGILFLLSGVLGLLGVIVFgqsVKLVFEEYFRQWMPE 159

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1937896878 156 ---NARYEFGQALFTGWAAASLCLLGGALLS 183
Cdd:pfam13903 160 hqnNVRISFGWSFALAWAGVVLSLLAGLLFL 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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