|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
14-440 |
0e+00 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 643.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 14 DGGWGWVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGL 93
Cdd:TIGR00892 13 DGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGGL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 94 LASAGMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGW 173
Cdd:TIGR00892 93 LASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFGW 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 174 RGGFLLFGGLLLHCCACGAVMRPPPGPQPRPDP-----APPGGRARH----------RQLLDLAVCTDRTFMVYMVTKFL 238
Cdd:TIGR00892 173 RGSFLILGGLLLHCCVCGALMRPVGPSQRVSKSkskegLPPDGSTKKlskkstaekiNRFLDFSLFTHRGFLVYLSGNVI 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 239 MALGLFVPAILLVNYAKDAGVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRPHVPYLFSLALLANGLTDLISARARS 318
Cdd:TIGR00892 253 MFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPHVQYLFSFALLFNGLTHLLCALAGD 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 319 YGTLVAFCIAFGLSYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVL 398
Cdd:TIGR00892 333 YTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVS 412
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 386781535 399 AGVFMAVTTYCCQRCSKDIPPGPSAEGGTSDTEDVEAE-RDSE 440
Cdd:TIGR00892 413 AGLFLAIGNYINYRLLAKEQKAALEREGARDKKDAEGDsRESE 455
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
18-407 |
0e+00 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 601.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 18 GWVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASA 97
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 98 GMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGF 177
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 178 LLFGGLLLHCCACGAVMRPppgpqprpdpappggrarhrqlLDLAVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKDA 257
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRP----------------------LDFSVFRDRGFVIYTIAKFIMVLGLFVPPIFVVNYAKDI 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 258 GVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRPHVPYLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYGMVG 337
Cdd:cd17430 219 GVPDTEAAFLLSILGFIDIFARPACGVVAGLKWVRPRVVYLFSFAMLFNGLTDLCSATAADYGGLVVFCVFFGISYGMVG 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 338 ALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGVFMAVTT 407
Cdd:cd17430 299 ALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALFLALGN 368
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
18-403 |
2.39e-117 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 349.50 E-value: 2.39e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 18 GWVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASA 97
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 98 GMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGF 177
Cdd:cd17427 81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 178 LLFGGLLLHCCACGAVMRpppgpqprpdpaPPGGRARHrqlldlavctdRTFMVYMVTKFLMALGLFVPAILLVNYAKDA 257
Cdd:cd17427 161 LILGGLLLNCCVAGSLMR------------PLGPLFKH-----------RGFLIYLSGNVIMFLGFFAPIVFLAPYAKHM 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 258 GVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRPHVPYLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYGMVG 337
Cdd:cd17427 218 GIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIQYFFSFAVMYNGVCHLLCPLAEDYTGLVIYAVFFGFAFGMVS 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386781535 338 ALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGVFM 403
Cdd:cd17427 298 SVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIWL 363
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
18-405 |
7.46e-108 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 325.29 E-value: 7.46e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 18 GWVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASA 97
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 98 GMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGF 177
Cdd:cd17426 81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 178 LLFGGLLLHCCACGAVMRPPPGpqprpdpappggrarhRQLLDLAVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKDA 257
Cdd:cd17426 161 LILGGLLLNCCVAGSLMRPIGP----------------KPFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSNYAKSK 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 258 GVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRPHVPYLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYGMVG 337
Cdd:cd17426 225 QISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPRIQYFFAASVLYNGVCHLLAPLSTSYVGFCIYAIFFGFAFGWLS 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386781535 338 ALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGVFMAV 405
Cdd:cd17426 305 SVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIYLFI 372
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
18-403 |
2.73e-107 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 323.35 E-value: 2.73e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 18 GWVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASA 97
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 98 GMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGF 177
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 178 LLFGGLLLHCCACGAVMRpppgpqprpdpappggrarhrqlldlaVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKDA 257
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR---------------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 258 GVPDAEAAFLLSIVGFVDIVARPACGALAGlgRLRPHVPYLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYGMVG 337
Cdd:cd17352 214 GIDESDAAFLLSIIGISDIVGRILLGLLAD--KPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYS 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386781535 338 ALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGVFM 403
Cdd:cd17352 292 SLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLL 357
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
18-406 |
8.72e-103 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 312.09 E-value: 8.72e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 18 GWVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASA 97
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 98 GMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGF 177
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 178 LLFGGLLLHCCACGAVMRpppgpqprpdpappggrarhrqlldlAVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKDA 257
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMR--------------------------PFCSNTRYQIYTLGVTWMVLGFVLPLIYLVPYATSN 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 258 GVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRPHVPYLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYGMVG 337
Cdd:cd17425 215 GMDESKAALLLSILGFINIFMRPLAGLLSGLPVFKGRRIYLFSLALLLNGLSNLICAISASFPVLLVYCLLYSISMSGIG 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386781535 338 ALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGVFMAVT 406
Cdd:cd17425 295 SLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALFMGLS 363
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
18-405 |
4.31e-75 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 241.14 E-value: 4.31e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 18 GWVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASA 97
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 98 GMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGF 177
Cdd:cd17423 81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 178 LLFGGLLLHCCACGAVMRPPPGPQPRPDPAPPGGRArhrqlLDLAVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKDA 257
Cdd:cd17423 161 LLLSALSLHLVPCGALLRPLALPGDPPAPPRSLSAA-----FGLSLLTHRAFLRYALATTLINTGYFIPYVHLVAHARAL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 258 GVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRPhvPYLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYGMVG 337
Cdd:cd17423 236 GLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRL--LHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAGALA 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386781535 338 ALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVL-AGVFMAV 405
Cdd:cd17423 314 PLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLgSLILLTL 382
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
18-405 |
2.53e-67 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 220.39 E-value: 2.53e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 18 GWVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASA 97
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 98 GMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGF 177
Cdd:cd17422 81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 178 LLFGGLLLHCCACGAVMRpppgpqprpdpappggrarhrqlldlaVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKDA 257
Cdd:cd17422 161 LVVGALQLNIVVCGALLR---------------------------VLKEPGFICYALFGLFATLGFFAPQLYIIPLSLSL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 258 GVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRPhvPYLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYGMVG 337
Cdd:cd17422 214 GIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIRK--IYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVA 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 338 ALQFEVLM--ATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGVFMAV 405
Cdd:cd17422 292 GTHIPLLAedDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLAL 361
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
18-403 |
1.87e-60 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 202.35 E-value: 1.87e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 18 GWVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASA 97
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 98 GMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGF 177
Cdd:cd17424 81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 178 LLFGGLLLHCCACGAVMRPPPGPqprpdpappggrarhrqlldlavctdrTFMVYMVTKFLMALGLFVPAILLVNYAKDA 257
Cdd:cd17424 161 LILGGFVLNLCVCGALMRFLLMP---------------------------DFLVLAVSVLFLAYGCSPPFVYLVPYALSV 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 258 GVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRPHVPYLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYGMVG 337
Cdd:cd17424 214 GVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLFAVGMDGLCCLFLPILKTFPLLVPFSFTFGYFDGAYV 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386781535 338 ALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGVFM 403
Cdd:cd17424 294 ALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLL 359
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
18-403 |
3.90e-43 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 157.31 E-value: 3.90e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 18 GWVVLGACFVITGFAYGFPKAVSVFFRELKRDFGA-----GYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGG 92
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKlgdpeASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 93 LLASAGMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFG 172
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 173 WRGGFLLFGGLLLHCCACGAVMRpPPGPQPRPDPAPPGGRARH-------RQLLDLAVCTDRTFMVYMVTKFLMALGLFV 245
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYR-PLHPSPEDPKSKPGRRTLHsrinlflRKIFNVEIFKRKRYVIWALGIPLALFGYFV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 246 PAILLVNYAKDAGVPDAEAAFLLSIVGFVDIVARPACGALA----GLGRLrphvpYLFSLALLANGLTDLISARARSYGT 321
Cdd:cd17420 240 PYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIAdmppGVKKM-----YLQVLSFVSIGLMSMMIPLCNSFGI 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 322 LVAFCIAFGLSYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGV 401
Cdd:cd17420 315 LISVCLVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGSS 394
|
..
gi 386781535 402 FM 403
Cdd:cd17420 395 LL 396
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
18-401 |
2.35e-39 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 146.12 E-value: 2.35e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 18 GWVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASA 97
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 98 GMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLStLSPLGQLLGERFGWRGGF 177
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLTFA-LAPFTQLLLDEYDWQGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 178 LLFGGLLLHCCACGAVMRPppgpqprpdpappggrarhrqlLDLAVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKDA 257
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRP----------------------IDFSLLKDPFFCIYTWSFVFSQLAYFIPYFHLVARARTL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 258 GVPDAEAAFLLSIVGFVDIVARPACGALAG---LGRLRPHVPYlfslaLLANGLTDLISARARSYGTLVAFCIAFGLSYG 334
Cdd:cd17421 218 GIDPMDASFIISVAGITETVAQLASGWIADqnwIKKYHYHKAY-----LILCGVTNLLAPLATTYPLLMTYAVFFAIFCG 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 386781535 335 MVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGV 401
Cdd:cd17421 293 GYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSV 359
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
18-406 |
9.49e-38 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 141.88 E-value: 9.49e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 18 GWVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASA 97
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 98 GMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGF 177
Cdd:cd17428 81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 178 LLFGGLLLHCCACGAVMRpppgpqprpdpappggrarhrqlldlaVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKDA 257
Cdd:cd17428 161 LIVGALALNLLACGSLMR---------------------------LFKNRVFSALFIAILLFDIGAFPPSLLMEDVARSE 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 258 GVPDAEAAF-LLSIVGFVDIVARPACGALAGLGRLrpHVPYLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYGMV 336
Cdd:cd17428 214 NIIEEIALIpLVSIIGITTAIGKLILGVLADFKWV--NSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGNW 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 337 GALQFeVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGVFMAVT 406
Cdd:cd17428 292 SIFPY-VTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLLLLA 360
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
18-403 |
1.86e-33 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 130.68 E-value: 1.86e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 18 GWVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSD-----TAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGG 92
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKDDAqmrfkTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 93 LLASAGMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFG 172
Cdd:cd17464 81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 173 WRGGFLLFGGLLLHCCACGAVMRPPPGPQPRPDPAPPGGRARH-RQLLDLAVCTDRTFMVYMVTKFLMALGLFVPAILLV 251
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGKKRKFKCPPlKKIFNFNIWKSTGYRIWAFGIPAALFGYFVPYVHLM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 252 NYAKDAGVPDAEAAFLLSIVGFVDIVARPAcgalagLGRLRPHVP-----YLFSLALLANGLTDLISARARSYGTLVAFC 326
Cdd:cd17464 241 NHVKERFGEDVNKEVLLMCIGITSGIGRLI------FGRVADYIPgvkkvYLQVSSFFFIGLMSMMIPLCHVFGGLIAVC 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 386781535 327 IAFGLSYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGVFM 403
Cdd:cd17464 315 LFMGLFDGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGVPPIIGGIIL 391
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
18-393 |
6.15e-32 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 125.71 E-value: 6.15e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 18 GWVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASA 97
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 98 GMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGF 177
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 178 LLFGGLLLHCCACGAVMRpppgpqprpdpappggrarhrqlldlaVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKDA 257
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR---------------------------LFTNKVFVAFIFWALFAYCSFVIPFIHLPEIVKLY 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 258 GVPDAEAAF-LLSIVGFVDIVARPACGALAGLGRLRphVPYLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYGMV 336
Cdd:cd17429 214 GLSEQNDKFpLTSIIAIVHIFGKVILGIICDLPCIS--VWNVFILANFTLGVCILILPLMHTYTGLAIVCALIGFSSGYF 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 386781535 337 gALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAG 393
Cdd:cd17429 292 -SLMPVVTEDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCG 347
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
19-406 |
5.75e-30 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 120.76 E-value: 5.75e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 19 WVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASAG 98
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 99 MILASFASRlLELYLTAGVLTGLGLALNFQPSLIMLGLYF-ERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGF 177
Cdd:COG2223 84 LLLLALAVS-YWLLLLLGLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 178 LLFGglllhccACGAVMRPPPGPQPRPDPAPPGGRARHRQLLDLAVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKDA 257
Cdd:COG2223 163 LILG-------ILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 258 -GVPDAEAAFLLSIVGFVDIVARPACGALAglGRLRPHVPYLFSLALLANGLTdLISARARSYGTLVAFCIAFGLSYGMV 336
Cdd:COG2223 236 fGLSAATAGLLAALFALLGALGRPLGGWLS--DRIGGRRVLLIVFALMALGLL-LLALALGSLWLFLVLFLLLGLALGGG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 337 GALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGVFMAVT 406
Cdd:COG2223 313 NGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
18-406 |
1.32e-29 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 119.68 E-value: 1.32e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 18 GWVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASA 97
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 98 GMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLY-FERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGG 176
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWwFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 177 FLLFGGLLLHCCACGAVMRPPPGPQPRPDPAPPGGRARHRQLLdLAVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKD 256
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTL-KEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 257 AGVPDAEAAFLLSIVGFVDIVARPACGALAglGRLRPHVPYLFSLALLANGLTDLISARArSYGTLVAFCIAFGLSYGMV 336
Cdd:cd17355 240 RGISPAAAAVALALIGLFNIVGRLLSGWLG--DRYSPRRLLAASYALRALGLALLLLLPF-PPLALLLFAALFGLGWGAT 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 337 GALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGVFMAVT 406
Cdd:cd17355 317 VPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
18-403 |
1.42e-29 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 119.13 E-value: 1.42e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 18 GWVVLGACFVITGFAYGFPKAVSVFFRELKRDFG-----AGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGG 92
Cdd:cd17465 1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEdqkdqAVQFKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 93 LLASAGMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFG 172
Cdd:cd17465 81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 173 wrggfllfgglLLHCCACGAVMRPPPGPQPrpdpappggrarhrqlLDLAVCTDRTFMVYMVTKFLMALGLFVPAILLVN 252
Cdd:cd17465 161 -----------LAHTFQVLSLFMFIQIFLS----------------LTYKVFRRKTYRIWAFGIATAVLGYFVPYVHLMK 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 253 YAKDAGVPDAEAAFLLSIVGFVDIVARPACGAlagLGRLRPHVP--YLFSLALLANGLTDLISARARSYGTLVAFCIAFG 330
Cdd:cd17465 214 YVEEEFKENKREWVLLVCIGASSGIGRLMSGK---IGDLIPGLKkiYLQVASFLLLGIMSMMIPLCQVFEGVIVVCLFLG 290
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386781535 331 LSYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGVFM 403
Cdd:cd17465 291 LCDGCFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPIIGGTVL 363
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-405 |
9.41e-25 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 105.34 E-value: 9.41e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 15 GGWGWVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLL 94
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 95 ASAGMILASFASRLLELYLTAgVLTGLGLALNFQPSLIMLGLYF-ERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGW 173
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 174 RGGFLLFGGLllhcCACGAVMRpppgpqprpdpappggrarhrqlldlavctdrtFMVYMVTKFLMALGLFVPAILLVNY 253
Cdd:COG2271 164 RAAFLILGLP----GLLLALLR---------------------------------FWLLALAYFLVYFALYGFLTWLPTY 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 254 AKDA-GVPDAEAAFLLSIVGFVDIVARPACGALAglGRLRPHVPYLFSLALLANGLTDLISARARSYGTLVAFCIAFGLS 332
Cdd:COG2271 207 LVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLS--DRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFG 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386781535 333 YGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALkNYEIIFYLAGSEVVLAGVFMAV 405
Cdd:COG2271 285 LGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLLAALALLAALLALL 356
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
18-401 |
3.71e-23 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 100.95 E-value: 3.71e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 18 GWVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASA 97
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 98 GMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGF 177
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 178 LLFGGLLLHCCACGAVMRPPPGPQPRPDPAPPGGRARHRqlldLAVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKDA 257
Cdd:cd17314 161 TILGILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTM----GEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 258 GVPDAE-AAFLLSIVGFVDIVARPACGALAGLgRLRPHVPYLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYGMV 336
Cdd:cd17314 237 QLDAPSfVTKLMSIYGLFNAFGRLLWGIVADF-FGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGL 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386781535 337 GALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGV 401
Cdd:cd17314 316 FTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASA 380
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
22-372 |
6.25e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 90.94 E-value: 6.25e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 22 LGACFVITGFAYGFpkAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASAGMIL 101
Cdd:pfam07690 1 LFLAAFLAALGRSL--LGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 102 ASFASRLLELYLtAGVLTGLGLALNFQPSLIMLGLYF-ERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGFLLF 180
Cdd:pfam07690 79 LLFASSLWLLLV-LRVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 181 GGLllhcCACGAVMRPPPGPQPRPDPAPPGGRARHRQLLDLAVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKDAGVP 260
Cdd:pfam07690 158 AIL----SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 261 DAEAAFLLSIVGFVDIVARPACGALAG-LGRLRPHVPYLFSLALLANGLtdLISARARSYGTLVAFCIAFGLSYGMVGAL 339
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDrLGRRRRLLLALLLLILAALGL--LLLSLTLSSLWLLLALLLLGFGFGLVFPA 311
|
330 340 350
....*....|....*....|....*....|...
gi 386781535 340 QFEVLMATVGAPRFPSALGLVLLVEAVAVLIGP 372
Cdd:pfam07690 312 LNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
17-402 |
2.98e-18 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 86.47 E-value: 2.98e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 17 WGWVVLGACFVITGFAYGFP-KAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLA 95
Cdd:COG2807 14 AGRWLLLLAIVLVALNLRPAiTSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 96 SAGMILASFASRLLELYLTAgVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRG 175
Cdd:COG2807 94 AAGLLLRSLAPSVALLLAGT-ALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 176 GFLLFGGLllhcCACGAVMRPPPGPQPRPDPAPPGGRARHRQLLdlavcTDRTFMVYMVTKFLMALGLFVPAILLVNYAK 255
Cdd:COG2807 173 ALAVWALL----ALLALLLWLPLLRRRPAAAAAAPAAASLRSLW-----RSPLAWLLTLFFGLQSLLYYAVVAWLPPILR 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 256 DAGVPDAEAAFLLSIVGFVDIVARPACGALAglGRLRPHVPYLFSLALL-ANGLTDLISARArsyGTLVAFCIAFGLSYG 334
Cdd:COG2807 244 DAGLSAATAGLLLSLFQLAGIPGSLLVPLLA--DRLGDRRPLLLLLGLLgLAGLLGLLLAPG---SLPWLWAVLLGLGQG 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386781535 335 MVGALQFEVLMATVGAPRFPSAL-GLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGVF 402
Cdd:COG2807 319 GLFPLALTLIGLRARTPAEAAALsGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVA 387
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
19-363 |
1.25e-17 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 84.26 E-value: 1.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 19 WVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASAG 98
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 99 MILASFASRLLELYLtAGVLTGLGLALNFQPSLIMLGLYF-ERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGF 177
Cdd:COG2814 89 SLLCALAPSLWLLLA-ARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 178 LLFGGLllhCCACGAVMRPPPGPQPRPDPAPPGGRARHrqlldlaVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKD- 256
Cdd:COG2814 168 LVNAVL---ALLALLLLLRLLPESRPAARARLRGSLRE-------LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEv 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 257 AGVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRPhvpyLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYGMV 336
Cdd:COG2814 238 LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR----LLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLL 313
|
330 340
....*....|....*....|....*..
gi 386781535 337 GALQFEVLMATVGAPRFPSALGLVLLV 363
Cdd:COG2814 314 FPLLQALVAELAPPEARGRASGLYNSA 340
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
22-402 |
2.86e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 80.16 E-value: 2.86e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 22 LGACFVITGFAYGfpkAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASAGMIL 101
Cdd:cd06174 1 LLLGFFLTGLARG---LISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 102 ASFASrLLELYLTAGVLTGLGLALNFQPSLIMLGLYF-ERRRPLANGLAAAGSPVFLSTLSPLGQLLGER--FGWRGGFL 178
Cdd:cd06174 78 FAFAP-SFWLLLLGRFLLGLGSGLIDPAVLALIADLFpERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 179 LFGGLLLHCCACGAVMRPPPGPQPRPDPAPPGGRARHRQLLDLAVctDRTFMVYMVTKFLMALGLFVPAILLVNYAKD-A 257
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLK--NPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDlG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 258 GVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRphvPYLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYGMVG 337
Cdd:cd06174 235 GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGR---KPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLL 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386781535 338 ALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGVF 402
Cdd:cd06174 312 PLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
17-403 |
4.09e-16 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 79.96 E-value: 4.09e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 17 WGWVVLGACFvitGFAYGFpkavSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLAS 96
Cdd:cd17353 7 LGAVLMHLIL---GYQYAW----SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 97 AGMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAG---SPVFlstLSPLGQLLGERFG- 172
Cdd:cd17353 80 LGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGfglGSLI---FSPLIAYLINTVGv 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 173 WRGGFLLFGGLLLHCCACGAVMRPPPGPQPRPDPAPPGGRARH--RQLLDLAVCTDRTFMVYMVTKFLMALGLFVPAILL 250
Cdd:cd17353 157 PTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENspRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 251 VNYAKD-AGVPDAEAAFLLSIVGFVDIVARPACGALAG-LGRLRphvpyLFSLALLANGL-TDLISARARSYGTLVAFCI 327
Cdd:cd17353 237 KPIGQEfAGLDAGIAALAVSILSIFNGGGRPFWGWLSDkIGRKN-----TLSIAFLIQGVaMFLLPFIGSVAVLFVLGVA 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386781535 328 AFGLSYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALkNYEIIFYLAGSEVVLAGVFM 403
Cdd:cd17353 312 LIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTG-GYNAAFIIAAALSLVALALA 386
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
48-405 |
1.32e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 66.06 E-value: 1.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 48 RDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASAGMILASFASRLLELYLTAgVLTGLGLALNF 127
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR-FLQGLASAAVW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 128 QPSLIMLG-LYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGFLLFGGLLlhccACGAVMRPPPGPQPRPDP 206
Cdd:cd17325 103 PAAMALIAdIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA----LLALVLALLLLPEPRPPP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 207 APPGGRARHRQLLDLAVCTDRTFMVYMVTKFL--MALGLFVPAILLvnYAKD-AGVPDAEAAFLLSIVGFVDIVARPACG 283
Cdd:cd17325 179 NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVlaFAFGALEPFLPL--YAAElGGLSPAQIGLLFGAQGLASALSQPPAG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 284 ALA-GLGRLRphvpyLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYGMVGALQFEVLMATVGAPRFPSALGLVLL 362
Cdd:cd17325 257 KLSdRIGRKP-----LILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNT 331
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 386781535 363 VEAVAVLIGPPSAGRLVDALkNYEIIFYLAGSEVVLAGVFMAV 405
Cdd:cd17325 332 AFSLGMVLGPLLGGFLYDAF-GFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
77-404 |
5.06e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 58.02 E-value: 5.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 77 ILVTRFGCRPVMLAGGLLASAGMILASFASRLLELyLTAGVLTGLGLAlNFQP--SLIMLGLYFERRRPLANGLAAAGSP 154
Cdd:cd17475 53 WLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVL-LVLLFLVGAGYG-SVQPggGRAIMRWFPPRERGLAMGIRQTGVP 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 155 VFLSTLSPLGQLLGERFGWRGGFLLFGGLllhCCACGAVmrPPPGPQPRPDPAPPGGRARHRQLLDLAVCTDRTFMVYMV 234
Cdd:cd17475 131 LGGALAAALLPPLALHYGWRAAFVVAGLV---SILAAVL--FWLFYREPPAASAATESASTLLRSLKEVLRNRDVWLIAI 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 235 TKFLMALGLFVPAILLVNYAKDA-GVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRPHVPYLFSLALLANGLTDLIS 313
Cdd:cd17475 206 AGALLVAPQFALLTFLLLFLHDHlGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLS 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 314 ARARS--YGTLVAFCIAFGLSYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYL 391
Cdd:cd17475 286 LLSPGtpLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLA 365
|
330
....*....|...
gi 386781535 392 AGSEVVLAGVFMA 404
Cdd:cd17475 366 LALLLVLAALLLL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
20-412 |
1.02e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 54.09 E-value: 1.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 20 VVLGACFVITGFAYGfpkAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASAGM 99
Cdd:COG0738 11 IAIYLLFFLWGFATA---LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 100 ILASFASRLLeLYLTAGVLTGLGLALnFQPSL--IMLGLYFERRRPL------ANGLAAAGSPVFLSTLSplgqLLGERF 171
Cdd:COG0738 88 LLFALAPSYP-LLLLALFLLGLGLGL-LDVAAnpYVAALGPETAASRlnllhaFFSLGALLGPLLGGLLI----LLGLSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 172 GWRGGFLLFGGLLLhcCACGAVMRPPPGPQPRPDPAPPGGRARHRQLLdlavcTDRTFMVYMVTKFLMALGLFVPAILLV 251
Cdd:COG0738 162 SWHLPYLILAVLLL--LLALLFLRSKLPEIEEEEEEAAGSAASLKSLL-----KNPRLLLGGLAIFLYVGAEGAIGDWLP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 252 NYAKDA-GVPDAEAAFLLSIVGFVDIVARPACGALagLGRLRPHVPYLFSLALLANGLtdLISARARSYGTLVAFCIAFG 330
Cdd:COG0738 235 LYLKDVlGLSEATAALGLSLFWGGMTIGRFLGGFL--LKRFGPVRLLRLSALLAAVGL--LLALLAPGPWLALIGLALVG 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 331 LSYGMVGALQFEVLMATVGAPRfPSALGLVLLVEAVAVLIGPPSAGRLVDALkNYEIIFYLagseVVLAGVFMAVTTYCC 410
Cdd:COG0738 311 LGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAF-GLRAAFLV----PLVCYLLILLLALAL 384
|
..
gi 386781535 411 QR 412
Cdd:COG0738 385 KR 386
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
227-404 |
1.23e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 53.44 E-value: 1.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 227 RTFMVYMVTKFLMALGLFVPAILLVNYAKDAGVPDAEAAFLLSIVGFVDIVARPACGALAG-LGRLRphvpyLFSLALLA 305
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADrFGRRR-----VLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 306 NGLTDLISARARSYGTLVAFCIAFGLSYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALkNY 385
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF-GW 163
|
170
....*....|....*....
gi 386781535 386 EIIFYLAGSEVVLAGVFMA 404
Cdd:COG2814 164 RWVFLVNAVLALLALLLLL 182
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
74-405 |
3.50e-06 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 49.22 E-value: 3.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 74 LSSILVTRFGCRPVMLaGGLLASAGMILASFASRLLELYLTAGVLTGLGLALNFQP-SLIMLGLYFERRRPLANGL--AA 150
Cdd:cd06180 53 LASFLRRRGRARRLIR-GGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFgSNLVLHHATAAGRGHLIGLlfAG 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 151 AGSPVFLSTLSPLGqLLGERFGWRGGFLLFGGLLLHCCACGAVMRPPPGPQPRPDPAPPGGRARHRQLLdlavctdRTFM 230
Cdd:cd06180 132 VGLGIALSGLLVPA-GLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAAESAPGLNRPLW-------RLAL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 231 VYmvtkFLMALGLFVPAILLVNYAKDAGVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRPhvpyLFSLALLANGLTD 310
Cdd:cd06180 204 AY----GLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRR----ALAANLLVQAVGV 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 311 LISARARSYGTLVAFCIAFGLSY-GMVGALQFEVLMatVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIF 389
Cdd:cd06180 276 LLPLLSPGPAGLVLSAVLFGGTFmAITALVMALARE--LAPPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPAL 353
|
330
....*....|....*.
gi 386781535 390 YLAGSEVVLAGVFMAV 405
Cdd:cd06180 354 ILAAAALVVAALLALL 369
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
17-174 |
7.07e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 47.88 E-value: 7.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 17 WGWVVLGACFVITGFAYGfpkAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLAS 96
Cdd:COG0477 14 RALLALALGTFLEGLDFT---IVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386781535 97 AGMILASFASRLLELYLtAGVLTGLGLALNFQPSLIMLGLYF-ERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWR 174
Cdd:COG0477 91 LASLLCGLAPSPELLIA-ARALQGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
19-401 |
8.19e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 47.95 E-value: 8.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 19 WVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASAG 98
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 99 MILASFASRLLELYLtAGVLTGLGLALNFQPSLIMLGLYF-ERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGF 177
Cdd:cd17319 82 TALTGFATSLTSLYV-LRFLLGVAEAGFFPGAIKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 178 LLfgglllhCCACGAVMRPPPgpqprpdpappggRARHRQLLDLAVCtdrTFMVYMVTKFLMAlglFVPAILlvnyAKDA 257
Cdd:cd17319 161 II-------EGLLGLLLAVLW-------------WFYLRQVWGLALG---YFGINYALYGLLT---WLPTYL----KQAR 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 258 GVPDAEAAFLLSIVGFVDIVARPACGALAG---LGRLRPH--VPYLFS-LALLANGLTDLIsararsYGTLVAFCIAFGL 331
Cdd:cd17319 211 GFSLKQVGLLAAIPFLAGAIGMILGGRLSDrllRGARRLViiIGLLLAaVGLLLAYLTTSP------VVAVILLSLAGFG 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 332 sYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGV 401
Cdd:cd17319 285 -IGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAAL 353
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
237-404 |
8.75e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.85 E-value: 8.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 237 FLMALGLFVPAILLVNYAKDAGVPDAEAAFLLSIVGFVDIVARPACGALAGlgRLRPHVPYLFSLALLANGLtdLISARA 316
Cdd:cd17324 9 FAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSD--RIERRRLLLVLLLLFILGN--LLAALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 317 RSYGTLVAFCIAFGLSYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPsAGRLVDALKNYEIIFYLAGSEV 396
Cdd:cd17324 85 PSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRP-LGGLLGQLLGWRAAFLAIAVLA 163
|
....*...
gi 386781535 397 VLAGVFMA 404
Cdd:cd17324 164 LLAALLLW 171
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
237-403 |
1.58e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 43.72 E-value: 1.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 237 FLMALGLFVPAILLVNYAKDAGVPDAEAAFLLSIVGFVDIVARPACGALAglGRLRPHVPYLFSLALLAngLTDLISARA 316
Cdd:cd17325 6 FLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLS--DRFGRKRLLLLGLLLLA--VSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 317 RSYGTLVAFCIAFGLSYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALkNYEIIFYLAGSEV 396
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-GYRAPFLVCAALA 160
|
....*..
gi 386781535 397 VLAGVFM 403
Cdd:cd17325 161 LLALVLA 167
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
73-403 |
1.89e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 43.74 E-value: 1.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 73 PLSSILVTRFGCRPVMLAGGLLASAGMILASFASRLLeLYLTAGVLTGLGLALNFQPSLIMLGLYFERRRpLANGLAAAG 152
Cdd:cd17489 49 PFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA-LLLVLRLIHGIGWGAFTTAAATLVADIIPPSR-RGEGIGYYG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 153 SPVFLSTL--SPLGQLLGERFGWRGGFLLFGGLLLHCCACGAVMRPPPGPQPRPDPAPPGGRARHRqlldlavctDRTFM 230
Cdd:cd17489 127 LATTLAMAlgPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLV---------EKKVL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 231 VYMVTKFLMALGLFVPAILLVNYAKDAGVpdAEAAFLLSIVGFVDIVARPACGALAglGRLRPHVPYLFSLALLANGLtd 310
Cdd:cd17489 198 PPALILFLASIAYGAISTFLPLYAAERGI--SNAGLFFTVYAIALLLSRPFSGKLS--DRKGPKTVIIPGLLLLALGL-- 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 311 LISARARSYGTLVAFCIAFGLSYGMV-GALQFEVLmATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALkNYEIIF 389
Cdd:cd17489 272 LLLSFAGSPWMLLLAAVLYGLGFGLLfPALQALAV-DLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF-GYRAMF 349
|
330
....*....|....
gi 386781535 390 YLAGSEVVLAGVFM 403
Cdd:cd17489 350 LLAAVVVLLALVLY 363
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
233-429 |
2.18e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 43.35 E-value: 2.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 233 MVTKFLMALGLFVPAILLVNYAKDAGVPDAEAAFLLSIVGFVDIVARPACGALagLGRLRPHVPYLFSLALLAngLTDLI 312
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRL--LDRFGRKRLLLIGLLIFA--LATLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 313 SARARSYGTLVAFCIAFGLSYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALkNYEIIFyla 392
Cdd:cd17489 78 YLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL-GFAVLF--- 153
|
170 180 190
....*....|....*....|....*....|....*..
gi 386781535 393 gsevVLAGVFMAVTTYCCQRCSKDIPPGPSAEGGTSD 429
Cdd:cd17489 154 ----IVAAVLALLALLLVFLVKDPPPVAAEEAEAGTR 186
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
237-405 |
2.27e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.18 E-value: 2.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 237 FLMALGLFVPAILLVNY-AKDAGVPDAEAAFLLSIVGFVDIVARPACGALAG-LGRLRphvpyLFSLALLANGLTDLISA 314
Cdd:pfam07690 6 FLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDrFGRRR-----VLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 315 RARSYGTLVAFCIAFGLSYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALkNYEIIFYLAGS 394
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-GWRAAFLILAI 159
|
170
....*....|.
gi 386781535 395 EVVLAGVFMAV 405
Cdd:pfam07690 160 LSLLAAVLLLL 170
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
24-164 |
2.72e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 43.38 E-value: 2.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 24 ACFVITGFAYGFPKAVSVFFRELKRDFGAGySDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASAGMILAS 103
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLGPS-SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 386781535 104 FASRlLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFlSTLSPLG 164
Cdd:cd06179 81 TAKS-VNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPG-SALGPLI 139
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
38-336 |
3.45e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.95 E-value: 3.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 38 AVSVFFRELKRDFGAGYSDTAWVSSI-MLAMLYGTgPLSSILVTRFGCRPVMLAGGLLASAGMILASFASRLLELyLTAG 116
Cdd:cd17503 14 IVNVALPTIMGDLGASLDTVQWVITSyLLALAIMI-PLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASL-IIFR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 117 VLTGLGLALnFQPS--LIMLGLYFERRRPLANGLAAAGSpVFLSTLSP-LGQLLGERFGWRGGFLLFGGLLLHCCACGAv 193
Cdd:cd17503 92 ILQGFGGGV-LIPLaqTILLRIYPPEKRGAAMGLVGLVI-LLAPAIGPtLGGWLTDNLSWRWIFYINLPIGILALLLAP- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 194 mrpppgpqprpdpappggrarhrqLLDLAVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKD-AGVPDAEAAFLLSIVG 272
Cdd:cd17503 169 ------------------------LLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNvLGYSAFESGLVLAPGG 224
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386781535 273 FVDIVARPACGALagLGRLRPHVPYLFSLALLANGLTDLISARARSYGTLVAFCIA-FGLSYGMV 336
Cdd:cd17503 225 LASAILSPLVGRL--LDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFiRGLGMGLV 287
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
222-381 |
4.21e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.58 E-value: 4.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 222 AVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKDA-GVPDAEAAFLLSIVGFVDIVARPACGALAglGRLRPHVPYLFS 300
Cdd:COG2211 223 ALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLA--KRFGKKKAFIIG 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 301 LALLANGLTDLISARARSYGTLVAFCIAFGLSYGMVGALQFEVLMATV-------GAPRFPSALGLVLLVEAVAVLIGPP 373
Cdd:COG2211 301 LLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktGRRREGLYFGIFTFAIKLGQALAGA 380
|
....*...
gi 386781535 374 SAGRLVDA 381
Cdd:COG2211 381 LAGLLLAL 388
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
45-174 |
4.25e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 42.54 E-value: 4.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 45 ELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASAGMILASFASRLlELYLTAGVLTGLGLA 124
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF-ALLLLARALAGLAHG 102
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 386781535 125 LNFQPSLIMLGLYF-ERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWR 174
Cdd:cd17324 103 GFWAIAAAYAADLVpPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWR 153
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
46-407 |
5.93e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 42.18 E-value: 5.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 46 LKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASAGMILASFASRLLELYLtAGVLTGLGLAL 125
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIA-GRALQGIGGAV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 126 nFQPSLIMLGLYF-ERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRggfllfggLLLHCCACGAVMRPPPGPqprp 204
Cdd:cd17504 101 -FPLAFALVREEFpPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWR--------WIFWTAAPVAVLLAALVP---- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 205 dpappggrarhrqLLDLAVCTDRTFMVYMVTKFLMALGLF-----VPAILLVNYAKDAGVPDAEAAFLLSIVGFVDIVAR 279
Cdd:cd17504 168 -------------LIDLRLLRRRNVLLANITALLAGFGMFmvfqlLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 280 PACGALAglGRLRPHVPYLFSLALLANGLTdLISARARSYGTLVAFCIAFGLSYGMVGALQFEVLMATVGAPRFPSALGL 359
Cdd:cd17504 235 PLAGRLI--ARVGPRRVLLIGLVISAVGLL-LLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGM 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 386781535 360 VLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEV-VLAGVFMAVTT 407
Cdd:cd17504 312 NTVLRTIGSAIGPAIAGAILTTYTVSITSGGVPTEGAyVLAFLIGAALA 360
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
19-125 |
8.23e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.81 E-value: 8.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 19 WVVLGACFVITGFAYGFPKAVSVFFreLKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASAG 98
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYY--FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100
....*....|....*....|....*...
gi 386781535 99 MILASFASRL-LELYLTAGVLTGLGLAL 125
Cdd:COG2211 308 LLLLFFLGPGnLWLLLVLAALAGIGLGA 335
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
226-403 |
1.05e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 41.37 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 226 DRTFMVYMVTKFLMALGLFvPAILLVNYAKDAGVPDAEAAFLLSIVGFVDIVARPACGALAGlgrlRPHVPYLFSLALLA 305
Cdd:cd17370 199 PKAFWLYLLAVALFALGNF-SFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSD----RIGRKKLLILGYLS 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 306 NGLTDLISARARSYGTLVAFCIAFGLSYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALkNY 385
Cdd:cd17370 274 LALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI-SP 352
|
170
....*....|....*...
gi 386781535 386 EIIFYLAGSEVVLAGVFM 403
Cdd:cd17370 353 SAAFLFSAVLALIALLLL 370
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
48-174 |
2.01e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 40.23 E-value: 2.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 48 RDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASAGMILASFASRLLELyLTAGVLTGLGLALNF 127
Cdd:cd17321 24 RDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL-IAARALQGIGAAAIM 102
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 386781535 128 QPSLIMLGLYF-ERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWR 174
Cdd:cd17321 103 PASLALIAATFpGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWR 150
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
19-148 |
2.06e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 40.25 E-value: 2.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 19 WVVLGACFVITGFAYGFPKAVSVFFrELKRDFGAGYSDTA---WVSSIMLAMLYGtGPLSSILVTRFGCRPVMLAGGLLA 95
Cdd:cd17504 180 LLANITALLAGFGMFMVFQLLPQLL-QLPTPTGFGLGITEaglLLLPGALVMLIA-GPLAGRLIARVGPRRVLLIGLVIS 257
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 386781535 96 SAGMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRP-LANGL 148
Cdd:cd17504 258 AVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTgIATGM 311
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
71-168 |
2.22e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 40.23 E-value: 2.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 71 TGPLSSILVTRFGCRPVMLAGGLLASAGMILASFASRLLELYLTAG--VLTGLGLALNFQP--SLIMLGLYFERRrplan 146
Cdd:cd17321 220 AAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPglVLLGLGLGLFATPltNAALSSVPKEKA----- 294
|
90 100
....*....|....*....|..
gi 386781535 147 GLAAAgspvFLSTLSPLGQLLG 168
Cdd:cd17321 295 GAASG----ILNTARQLGGALG 312
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
46-174 |
2.46e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 39.88 E-value: 2.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 46 LKRDFGAGYSDTAWVSSI-MLAMLYGT---GPLSSilvtRFGCRPVMLAGGLLASAGMILASFASRLLELYLtAGVLTGL 121
Cdd:cd17365 25 LAQDWGLSPAQLGPVGSAaLFGMAIGAllaGPLAD----RFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL-LRFLTGL 99
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 386781535 122 GL--ALnfqPSLIMLGLYF--ERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWR 174
Cdd:cd17365 100 GLgaAM---PNAITLVSEYapARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWR 153
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
237-438 |
2.83e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 39.86 E-value: 2.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 237 FLMALGLFVPAILLVNYAKDAGVPDAEAAFLLSIVGFVDIVARPACGALAGlgRLRPHVPYLFSLALLANGLtdLISARA 316
Cdd:COG2223 15 FLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVD--RFGPRRVLLIGLLLLGIGL--LLLALA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 317 RSYGTLVAFCIAFGLSYGMVgalqFEVLMATVG----APRFPSALGLVLLVEAVAVLIGPPSAGRLVDALkNYEIIFYLA 392
Cdd:COG2223 91 VSYWLLLLLGLLLGIGGGGS----FAVGIALVSkwfpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF-GWRNAFLIL 165
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 386781535 393 GsevvlagVFMAVTTYCCQRCSKDIPPGPSAEGGTSDTEDVEAERD 438
Cdd:COG2223 166 G-------ILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRD 204
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
18-176 |
2.97e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 40.03 E-value: 2.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 18 GWVVLGACFVITGFAyGFPKAVSVF-FRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLAS 96
Cdd:TIGR00895 15 QWRAIILSFLIMLMD-GYDLAAMGFaAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 97 AGMILASFASRLLELyLTAGVLTGLGLALNFqPSLIMLGLYF--ERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWR 174
Cdd:TIGR00895 94 VFTLLCALATNVTQL-LILRFLAGLGLGGLM-PNLNALVSEYapKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWR 171
|
..
gi 386781535 175 GG 176
Cdd:TIGR00895 172 SL 173
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
45-402 |
3.19e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 39.86 E-value: 3.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 45 ELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASAGMILASFASRLLELyLTAGVLTGLGLA 124
Cdd:cd17474 24 AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL-LAGRALQGIGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 125 LNFQPSLIMLG-LYFERRRP-------LANGLAAAGSPVflstlspLGQLLGErFGWRGGFLLFgglllhCCACGAVMRP 196
Cdd:cd17474 103 GLGPLALTLIGdLFEGGERAkamglyeAALGLGIAVGPL-------LGGLLAA-ISWRYPFFLL------AALIPVAFLA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 197 PPGPQPRPDPAPPGGRARHRQLLDLAVcTDRTFMVYMVTKFLMALGLFVPAILLVNYAKD-AGVPDAEAAFLLSIVGFVD 275
Cdd:cd17474 169 ILFLLPEPKEKAKSSSATKLRDLKKAL-RGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELlYGISPIIIGLLFAGWSVLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 276 IVARPACGALAGLgRLRPHVPYLFSLALLANGLtdLISARARSYGTLVAFCIAFGLSYGMVGALQFEVLMATVGAPRFPS 355
Cdd:cd17474 248 ALGSLFVGRLLKK-RFGARRILVIGLLLYALSL--LLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGT 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 386781535 356 ALGLVLLVEAVAVLIGPPSAGRLVDALkNYEIIFYLAGSEVVLAGVF 402
Cdd:cd17474 325 ASSLYNFVRFLGQAVGPLLFGLLLEIF-GLSAPFLVGAAIALAAAVL 370
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
72-174 |
3.49e-03 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 38.01 E-value: 3.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 72 GPLSSILVTRFGCRPVMLAGGLLASAGMILASFASRLLELYLtAGVLTGLGLALNFQPSLIMLG-LYFERRRPLANGLAA 150
Cdd:TIGR00880 15 SPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLII-ARFLQGFGAAFALVAGAALIAdIYPPEERGVALGLMS 93
|
90 100
....*....|....*....|....
gi 386781535 151 AGSPVFLSTLSPLGQLLGERFGWR 174
Cdd:TIGR00880 94 AGIALGPLLGPPLGGVLAQFLGWR 117
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
30-171 |
5.47e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 39.17 E-value: 5.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 30 GFAYGFPKAVSVFFRE-----LKRDFGAGYSDT--AWVSSIMLAMLYGTG----PLSSILVTRFGCRPVMLAGGLLA--S 96
Cdd:cd17357 13 GYNIGVVNAPQEVFKEfindtLVDRYGLNLSDSelDLLWSLIVSIFFIGGaigsFISAFLANRFGRKNGLLISNALLvvS 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386781535 97 AGMILASFASRLLELYLTAGVLTGL--GLALNFQPslimlgLYFERRRPLAN-GLAAAGSPVFLSTLSPLGQLLGERF 171
Cdd:cd17357 93 SLLMFLSKSAKSPELLIFGRFLVGIacGLSTGFVP------MYLQEISPSELrGALGSLTQIGVTLGILLGQVFGLPS 164
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
232-391 |
7.06e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.71 E-value: 7.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 232 YMVTKFLMALGLFVPAILLVNYAKDAGVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRPhvpyLFSLALLANGLTDL 311
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRR----LFLTALALFTLGSL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 312 ISARARSYGTLVAFCIAFGLSYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALkNYEIIFYL 391
Cdd:cd17503 77 LCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNL-SWRWIFYI 155
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
230-403 |
7.31e-03 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 38.51 E-value: 7.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 230 MVYMVTKFLMALGLFVPAILLVNYAKDAGVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRPhvpyLFSLALLANGLT 309
Cdd:pfam06779 196 WILTLAYGLAGFGYIITATFLPAMARDGFGGPAAAALFWSLFGLAAALGVLVWLRAAKRWGTRP----ALTAALLIQALG 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781535 310 DLISARARSYGTLVAFCIAFGLSYGMVGALQFEvLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIF 389
Cdd:pfam06779 272 VLLSLLSPSPAGLAVSSLLFGGTFMAITSLVMQ-LARELAPPAPRRLLGLMTASFGIGQILGPLLASLLTAATGGLTPAL 350
|
170
....*....|....
gi 386781535 390 YLAGSEVVLAGVFM 403
Cdd:pfam06779 351 LLAAAALVLAALIV 364
|
|
| |
