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Conserved domains on  [gi|13929106|ref|NP_113970|]
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vesicular inhibitory amino acid transporter [Rattus norvegicus]

Protein Classification

amino acid transporter( domain architecture ID 10478724)

amino acid transporter is involved in amino acid transport across membranes, similar to Arabidopsis thaliana amino acid-proton symporters and mammalian sodium-coupled neutral amino acid transporter 3, which is an amino acid/proton antiporter

Gene Ontology:  GO:0016020|GO:0022857|GO:0003333
SCOP:  4002722
TCDB:  2.A.18.2

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
115-512 1.52e-103

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


:

Pssm-ID: 279788  Cd Length: 410  Bit Score: 316.56  E-value: 1.52e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929106   115 KITAWEAGWNVTNAIQGMFVLGLPYAILHGGYL-GLFLIIFAAVVCCYTGKILIACLYEENEDGevvRVRDSYVAIAnac 193
Cdd:pfam01490   2 TISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIpGLILLLIVGLISLYTAHLLVRCSKEVPVTG---KRNKSYGDLG--- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929106   194 caprFPTLGGR---VVNVAQIIELVMTCILYVVVSGNLMYNSFPG----LPVSQKSWSIIATAVLLPCAFLKNLKAVSKF 266
Cdd:pfam01490  76 ----YRLLGPKgrlLILFAILLNLFGVCISYLIFAGDNLPAIFDSffdtCPISLVYFIIIFGLIFIPLSFIPNLSALSIL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929106   267 SLLCTLAHFVINILVIAY----CLSRARDWAWEKVKFYIDVKKFPISIGIIVFSYTSQIFLPSLEGNMQQPSEFHCMM-- 340
Cdd:pfam01490 152 SLLAAVSSLYYIVILVLSvaegIVLTAQGVGHLGSKTNIKLAGTFLAIGIIVFAFEGHAVLLPIQNEMKNPSKFKAMTki 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929106   341 -NWTHIAACVLKGLFALVAYLTWADETKEVITDNLPGS--IRAVVNIFLVAKALLSYPLPFFAAVEVLEKSLFQEgsRAF 417
Cdd:pfam01490 232 lLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKSawLIDIANLLLVLHVILSFPLQLFPIRQIVENLLFRK--EAP 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929106   418 FPACYGGDGRLKSWGLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFH-----LRLLWRKLLWHQVFF 492
Cdd:pfam01490 310 FGASGKNNPKSKLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHlklkkTKKKSQEKLWKPDIL 389
                         410       420
                  ....*....|....*....|
gi 13929106   493 DVAIFVIGGICSVSGFVHSL 512
Cdd:pfam01490 390 DVICIVIGLLLMAYGVAGLI 409
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
115-512 1.52e-103

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 316.56  E-value: 1.52e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929106   115 KITAWEAGWNVTNAIQGMFVLGLPYAILHGGYL-GLFLIIFAAVVCCYTGKILIACLYEENEDGevvRVRDSYVAIAnac 193
Cdd:pfam01490   2 TISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIpGLILLLIVGLISLYTAHLLVRCSKEVPVTG---KRNKSYGDLG--- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929106   194 caprFPTLGGR---VVNVAQIIELVMTCILYVVVSGNLMYNSFPG----LPVSQKSWSIIATAVLLPCAFLKNLKAVSKF 266
Cdd:pfam01490  76 ----YRLLGPKgrlLILFAILLNLFGVCISYLIFAGDNLPAIFDSffdtCPISLVYFIIIFGLIFIPLSFIPNLSALSIL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929106   267 SLLCTLAHFVINILVIAY----CLSRARDWAWEKVKFYIDVKKFPISIGIIVFSYTSQIFLPSLEGNMQQPSEFHCMM-- 340
Cdd:pfam01490 152 SLLAAVSSLYYIVILVLSvaegIVLTAQGVGHLGSKTNIKLAGTFLAIGIIVFAFEGHAVLLPIQNEMKNPSKFKAMTki 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929106   341 -NWTHIAACVLKGLFALVAYLTWADETKEVITDNLPGS--IRAVVNIFLVAKALLSYPLPFFAAVEVLEKSLFQEgsRAF 417
Cdd:pfam01490 232 lLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKSawLIDIANLLLVLHVILSFPLQLFPIRQIVENLLFRK--EAP 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929106   418 FPACYGGDGRLKSWGLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFH-----LRLLWRKLLWHQVFF 492
Cdd:pfam01490 310 FGASGKNNPKSKLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHlklkkTKKKSQEKLWKPDIL 389
                         410       420
                  ....*....|....*....|
gi 13929106   493 DVAIFVIGGICSVSGFVHSL 512
Cdd:pfam01490 390 DVICIVIGLLLMAYGVAGLI 409
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
115-512 1.52e-103

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 316.56  E-value: 1.52e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929106   115 KITAWEAGWNVTNAIQGMFVLGLPYAILHGGYL-GLFLIIFAAVVCCYTGKILIACLYEENEDGevvRVRDSYVAIAnac 193
Cdd:pfam01490   2 TISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIpGLILLLIVGLISLYTAHLLVRCSKEVPVTG---KRNKSYGDLG--- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929106   194 caprFPTLGGR---VVNVAQIIELVMTCILYVVVSGNLMYNSFPG----LPVSQKSWSIIATAVLLPCAFLKNLKAVSKF 266
Cdd:pfam01490  76 ----YRLLGPKgrlLILFAILLNLFGVCISYLIFAGDNLPAIFDSffdtCPISLVYFIIIFGLIFIPLSFIPNLSALSIL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929106   267 SLLCTLAHFVINILVIAY----CLSRARDWAWEKVKFYIDVKKFPISIGIIVFSYTSQIFLPSLEGNMQQPSEFHCMM-- 340
Cdd:pfam01490 152 SLLAAVSSLYYIVILVLSvaegIVLTAQGVGHLGSKTNIKLAGTFLAIGIIVFAFEGHAVLLPIQNEMKNPSKFKAMTki 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929106   341 -NWTHIAACVLKGLFALVAYLTWADETKEVITDNLPGS--IRAVVNIFLVAKALLSYPLPFFAAVEVLEKSLFQEgsRAF 417
Cdd:pfam01490 232 lLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKSawLIDIANLLLVLHVILSFPLQLFPIRQIVENLLFRK--EAP 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929106   418 FPACYGGDGRLKSWGLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFH-----LRLLWRKLLWHQVFF 492
Cdd:pfam01490 310 FGASGKNNPKSKLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHlklkkTKKKSQEKLWKPDIL 389
                         410       420
                  ....*....|....*....|
gi 13929106   493 DVAIFVIGGICSVSGFVHSL 512
Cdd:pfam01490 390 DVICIVIGLLLMAYGVAGLI 409
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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