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Conserved domains on  [gi|24041012|ref|NP_114434|]
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kremen protein 1 isoform 2 precursor [Homo sapiens]

Protein Classification

WSC domain-containing protein( domain architecture ID 10059194)

WSC (cell wall integrity and stress response component) domain-containing protein may bind carbohydrates; the domain contains up to eight conserved cysteine residues that may be involved in disulfide bridges

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
KR cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as ...
33-116 5.91e-25

Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and fibrinolytic proteins, some serine proteases and plasma proteins. Plasminogen-like kringles possess affinity for free lysine and lysine-containing peptides.


:

Pssm-ID: 238056  Cd Length: 83  Bit Score: 98.22  E-value: 5.91e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041012  33 ECFTANGADYRGTQNWTAlqGGKPCLFWNET--FQHPYNTLKYPNGeggLGEHNYCRNPDGDV-SPWCYVAehEDGVYWK 109
Cdd:cd00108   3 DCYWGNGESYRGTVSTTK--SGKPCQRWNSQlpHQHKFNPERFPEG---LLEENYCRNPDGDPeGPWCYTT--DPNVRWE 75

                ....*..
gi 24041012 110 YCEIPAC 116
Cdd:cd00108  76 YCDIPRC 82
WSC pfam01822
WSC domain; This domain is involved in carbohydrate binding.
121-202 2.35e-24

WSC domain; This domain is involved in carbohydrate binding.


:

Pssm-ID: 460348  Cd Length: 82  Bit Score: 96.37  E-value: 2.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041012   121 NLGCYKDHGNPPPLTGTSK-TSNKLTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWkYGEAASTECNSVCFGDHTQP 199
Cdd:pfam01822   1 YLGCYSDGTGGRRLLLGSSgDYDDMTPEKCIAFCSAAGYTYAGLEYGGECYCGNSLPSG-SALADSSDCNTPCPGDSSQT 79

                  ...
gi 24041012   200 CGG 202
Cdd:pfam01822  80 CGG 82
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
216-322 3.72e-21

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 88.62  E-value: 3.72e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041012 216 CGGNYSAMSS-VVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSA----DMVELLDGYTH--RVLARFHGRS 288
Cdd:cd00041   1 CGGTLTASTSgTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPncsyDYLEIYDGPSTssPLLGRFCGST 80
                        90       100       110
                ....*....|....*....|....*....|....
gi 24041012 289 RPPlSFNVSLDFVILYFFSDRINQAQGFAVLYQA 322
Cdd:cd00041  81 LPP-PIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
 
Name Accession Description Interval E-value
KR cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as ...
33-116 5.91e-25

Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and fibrinolytic proteins, some serine proteases and plasma proteins. Plasminogen-like kringles possess affinity for free lysine and lysine-containing peptides.


Pssm-ID: 238056  Cd Length: 83  Bit Score: 98.22  E-value: 5.91e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041012  33 ECFTANGADYRGTQNWTAlqGGKPCLFWNET--FQHPYNTLKYPNGeggLGEHNYCRNPDGDV-SPWCYVAehEDGVYWK 109
Cdd:cd00108   3 DCYWGNGESYRGTVSTTK--SGKPCQRWNSQlpHQHKFNPERFPEG---LLEENYCRNPDGDPeGPWCYTT--DPNVRWE 75

                ....*..
gi 24041012 110 YCEIPAC 116
Cdd:cd00108  76 YCDIPRC 82
WSC pfam01822
WSC domain; This domain is involved in carbohydrate binding.
121-202 2.35e-24

WSC domain; This domain is involved in carbohydrate binding.


Pssm-ID: 460348  Cd Length: 82  Bit Score: 96.37  E-value: 2.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041012   121 NLGCYKDHGNPPPLTGTSK-TSNKLTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWkYGEAASTECNSVCFGDHTQP 199
Cdd:pfam01822   1 YLGCYSDGTGGRRLLLGSSgDYDDMTPEKCIAFCSAAGYTYAGLEYGGECYCGNSLPSG-SALADSSDCNTPCPGDSSQT 79

                  ...
gi 24041012   200 CGG 202
Cdd:pfam01822  80 CGG 82
KR smart00130
Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like ...
33-116 2.51e-24

Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like receptors. Can occur in up to 38 copies (in apolipoprotein(a)). Plasminogen-like kringles possess affinity for free lysine and lysine- containing peptides.


Pssm-ID: 214527  Cd Length: 83  Bit Score: 96.31  E-value: 2.51e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041012     33 ECFTANGADYRGTQNWTAlqGGKPCLFWNET--FQHPYNTLKYPNGeggLGEHNYCRNPDGDVS-PWCYVAehEDGVYWK 109
Cdd:smart00130   2 ECYAGNGESYRGTVSVTK--SGKPCQRWDSQtpHLHRFTPESFPDL---GLEENYCRNPDGDSEgPWCYTT--DPNVRWE 74

                   ....*..
gi 24041012    110 YCEIPAC 116
Cdd:smart00130  75 YCDIPQC 81
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
216-322 3.72e-21

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 88.62  E-value: 3.72e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041012 216 CGGNYSAMSS-VVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSA----DMVELLDGYTH--RVLARFHGRS 288
Cdd:cd00041   1 CGGTLTASTSgTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPncsyDYLEIYDGPSTssPLLGRFCGST 80
                        90       100       110
                ....*....|....*....|....*....|....
gi 24041012 289 RPPlSFNVSLDFVILYFFSDRINQAQGFAVLYQA 322
Cdd:cd00041  81 LPP-PIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
Kringle pfam00051
Kringle domain; Kringle domains have been found in plasminogen, hepatocyte growth factors, ...
34-116 1.13e-19

Kringle domain; Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein A. Structure is disulfide-rich, nearly all-beta.


Pssm-ID: 395005  Cd Length: 79  Bit Score: 83.13  E-value: 1.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041012    34 CFTANGADYRGTQNWTAlqGGKPCLFWNETFQH---PYNTLKYPNGegGLGEhNYCRNPDGDVSPWCYVAehEDGVYWKY 110
Cdd:pfam00051   1 CYHGNGESYRGTVSTTE--SGRPCQAWDSQTPHrhsKYTPENFPAK--GLGE-NYCRNPDGDERPWCYTT--DPRVRWEY 73

                  ....*.
gi 24041012   111 CEIPAC 116
Cdd:pfam00051  74 CDIPRC 79
CUB pfam00431
CUB domain;
216-320 2.14e-18

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 80.42  E-value: 2.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041012   216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDS----ADMVELLDGY--THRVLARFHGrSR 289
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHdecgYDYVEIRDGPsaSSPLLGRFCG-SG 79
                          90       100       110
                  ....*....|....*....|....*....|.
gi 24041012   290 PPLSFNVSLDFVILYFFSDRINQAQGFAVLY 320
Cdd:pfam00431  80 IPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
226-320 3.20e-16

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 73.96  E-value: 3.20e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041012    226 VVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSA----DMVELLDGYT--HRVLARFHGRSRPPLSFNVSLD 299
Cdd:smart00042   2 TITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDnceyDYVEIYDGPSasSPLLGRFCGSEAPPPVISSSSN 81
                           90       100
                   ....*....|....*....|.
gi 24041012    300 FVILYFFSDRINQAQGFAVLY 320
Cdd:smart00042  82 SLTLTFVSDSSVQKRGFSARY 102
WSC smart00321
present in yeast cell wall integrity and stress response component proteins; Domain present in ...
122-207 1.66e-06

present in yeast cell wall integrity and stress response component proteins; Domain present in WSC proteins, polycystin and fungal exoglucanase


Pssm-ID: 214616 [Multi-domain]  Cd Length: 95  Bit Score: 46.31  E-value: 1.66e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041012    122 LGCYKDhgnPPPLTGTSKTS---NKLTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKYGEAASTECNSVCFGDHTQ 198
Cdd:smart00321   5 VGCYSD---NSSRTLAAVSSyayHNMSVEACSNFCFSAGYALAALENGNECYCGDSLPSTSVSASDSSQCSTTCSGYPAE 81

                   ....*....
gi 24041012    199 PCGGDGRII 207
Cdd:smart00321  82 VCGGPNRLS 90
 
Name Accession Description Interval E-value
KR cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as ...
33-116 5.91e-25

Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and fibrinolytic proteins, some serine proteases and plasma proteins. Plasminogen-like kringles possess affinity for free lysine and lysine-containing peptides.


Pssm-ID: 238056  Cd Length: 83  Bit Score: 98.22  E-value: 5.91e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041012  33 ECFTANGADYRGTQNWTAlqGGKPCLFWNET--FQHPYNTLKYPNGeggLGEHNYCRNPDGDV-SPWCYVAehEDGVYWK 109
Cdd:cd00108   3 DCYWGNGESYRGTVSTTK--SGKPCQRWNSQlpHQHKFNPERFPEG---LLEENYCRNPDGDPeGPWCYTT--DPNVRWE 75

                ....*..
gi 24041012 110 YCEIPAC 116
Cdd:cd00108  76 YCDIPRC 82
WSC pfam01822
WSC domain; This domain is involved in carbohydrate binding.
121-202 2.35e-24

WSC domain; This domain is involved in carbohydrate binding.


Pssm-ID: 460348  Cd Length: 82  Bit Score: 96.37  E-value: 2.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041012   121 NLGCYKDHGNPPPLTGTSK-TSNKLTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWkYGEAASTECNSVCFGDHTQP 199
Cdd:pfam01822   1 YLGCYSDGTGGRRLLLGSSgDYDDMTPEKCIAFCSAAGYTYAGLEYGGECYCGNSLPSG-SALADSSDCNTPCPGDSSQT 79

                  ...
gi 24041012   200 CGG 202
Cdd:pfam01822  80 CGG 82
KR smart00130
Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like ...
33-116 2.51e-24

Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like receptors. Can occur in up to 38 copies (in apolipoprotein(a)). Plasminogen-like kringles possess affinity for free lysine and lysine- containing peptides.


Pssm-ID: 214527  Cd Length: 83  Bit Score: 96.31  E-value: 2.51e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041012     33 ECFTANGADYRGTQNWTAlqGGKPCLFWNET--FQHPYNTLKYPNGeggLGEHNYCRNPDGDVS-PWCYVAehEDGVYWK 109
Cdd:smart00130   2 ECYAGNGESYRGTVSVTK--SGKPCQRWDSQtpHLHRFTPESFPDL---GLEENYCRNPDGDSEgPWCYTT--DPNVRWE 74

                   ....*..
gi 24041012    110 YCEIPAC 116
Cdd:smart00130  75 YCDIPQC 81
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
216-322 3.72e-21

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 88.62  E-value: 3.72e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041012 216 CGGNYSAMSS-VVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSA----DMVELLDGYTH--RVLARFHGRS 288
Cdd:cd00041   1 CGGTLTASTSgTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPncsyDYLEIYDGPSTssPLLGRFCGST 80
                        90       100       110
                ....*....|....*....|....*....|....
gi 24041012 289 RPPlSFNVSLDFVILYFFSDRINQAQGFAVLYQA 322
Cdd:cd00041  81 LPP-PIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
Kringle pfam00051
Kringle domain; Kringle domains have been found in plasminogen, hepatocyte growth factors, ...
34-116 1.13e-19

Kringle domain; Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein A. Structure is disulfide-rich, nearly all-beta.


Pssm-ID: 395005  Cd Length: 79  Bit Score: 83.13  E-value: 1.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041012    34 CFTANGADYRGTQNWTAlqGGKPCLFWNETFQH---PYNTLKYPNGegGLGEhNYCRNPDGDVSPWCYVAehEDGVYWKY 110
Cdd:pfam00051   1 CYHGNGESYRGTVSTTE--SGRPCQAWDSQTPHrhsKYTPENFPAK--GLGE-NYCRNPDGDERPWCYTT--DPRVRWEY 73

                  ....*.
gi 24041012   111 CEIPAC 116
Cdd:pfam00051  74 CDIPRC 79
CUB pfam00431
CUB domain;
216-320 2.14e-18

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 80.42  E-value: 2.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041012   216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDS----ADMVELLDGY--THRVLARFHGrSR 289
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHdecgYDYVEIRDGPsaSSPLLGRFCG-SG 79
                          90       100       110
                  ....*....|....*....|....*....|.
gi 24041012   290 PPLSFNVSLDFVILYFFSDRINQAQGFAVLY 320
Cdd:pfam00431  80 IPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
226-320 3.20e-16

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 73.96  E-value: 3.20e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041012    226 VVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSA----DMVELLDGYT--HRVLARFHGRSRPPLSFNVSLD 299
Cdd:smart00042   2 TITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDnceyDYVEIYDGPSasSPLLGRFCGSEAPPPVISSSSN 81
                           90       100
                   ....*....|....*....|.
gi 24041012    300 FVILYFFSDRINQAQGFAVLY 320
Cdd:smart00042  82 SLTLTFVSDSSVQKRGFSARY 102
WSC smart00321
present in yeast cell wall integrity and stress response component proteins; Domain present in ...
122-207 1.66e-06

present in yeast cell wall integrity and stress response component proteins; Domain present in WSC proteins, polycystin and fungal exoglucanase


Pssm-ID: 214616 [Multi-domain]  Cd Length: 95  Bit Score: 46.31  E-value: 1.66e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041012    122 LGCYKDhgnPPPLTGTSKTS---NKLTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKYGEAASTECNSVCFGDHTQ 198
Cdd:smart00321   5 VGCYSD---NSSRTLAAVSSyayHNMSVEACSNFCFSAGYALAALENGNECYCGDSLPSTSVSASDSSQCSTTCSGYPAE 81

                   ....*....
gi 24041012    199 PCGGDGRII 207
Cdd:smart00321  82 VCGGPNRLS 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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