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Conserved domains on  [gi|14195599|ref|NP_115287|]
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protein phosphatase 1 regulatory subunit 12B isoform d [Homo sapiens]

Protein Classification

PRKG1_interact domain-containing protein( domain architecture ID 11239588)

PRKG1_interact domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRKG1_interact pfam15898
cGMP-dependent protein kinase interacting domain; This domain is found at the C-terminus of ...
 107-214 1.07e-30

cGMP-dependent protein kinase interacting domain; This domain is found at the C-terminus of protein phosphatase 1 regulatory subunits 12A, 12B and 12C. In protein phosphatase 1 regulatory subunit 12A it has been found to bind to cGMP-dependent protein kinase 1 via a leucine zipper motif located at the C-terminus of this domain.


:

Pssm-ID: 464927 [Multi-domain]  Cd Length: 102  Bit Score: 108.93  E-value: 1.07e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14195599   107 DYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEmknlhqLK 186
Cdd:pfam15898   1 DYKKLYEEELQENERLKRKLQDAQQELAELKSQLERLTQQRQESFSDRSSLLETEKREKRALERKISEMEEE------LK 74

                          90       100
                  ....*....|....*....|....*...
gi 14195599   187 QIQTLKQMNEQLQAENRALTRVVARLSE 214
Cdd:pfam15898  75 VLEDLRAENQRLKDENGALIRVISKLSK 102
 
Name Accession Description Interval E-value
PRKG1_interact pfam15898
cGMP-dependent protein kinase interacting domain; This domain is found at the C-terminus of ...
 107-214 1.07e-30

cGMP-dependent protein kinase interacting domain; This domain is found at the C-terminus of protein phosphatase 1 regulatory subunits 12A, 12B and 12C. In protein phosphatase 1 regulatory subunit 12A it has been found to bind to cGMP-dependent protein kinase 1 via a leucine zipper motif located at the C-terminus of this domain.


Pssm-ID: 464927 [Multi-domain]  Cd Length: 102  Bit Score: 108.93  E-value: 1.07e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14195599   107 DYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEmknlhqLK 186
Cdd:pfam15898   1 DYKKLYEEELQENERLKRKLQDAQQELAELKSQLERLTQQRQESFSDRSSLLETEKREKRALERKISEMEEE------LK 74

                          90       100
                  ....*....|....*....|....*...
gi 14195599   187 QIQTLKQMNEQLQAENRALTRVVARLSE 214
Cdd:pfam15898  75 VLEDLRAENQRLKDENGALIRVISKLSK 102
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 126-204 9.33e-04

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 39.93  E-value: 9.33e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14195599   126 LQEAQLELADIKSKLEKVAQQKQEktsdRSSVLEMEKRERRALERKMSEMEEEMKNLHQlkQIQTLKQMNEQLQAENRA 204
Cdd:PRK11448  144 LHALQQEVLTLKQQLELQAREKAQ----SQALAEAQQQELVALEGLAAELEEKQQELEA--QLEQLQEKAAETSQERKQ 216
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 110-219 4.65e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 37.44  E-value: 4.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14195599 110 KLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEktsdrssVLEMEKRERRALERKMSEMEEEMKNLHqlKQIQ 189
Cdd:COG4942 139 QYLKYLAPARREQAEELRADLAELAALRAELEAERAELEA-------LLAELEEERAALEALKAERQKLLARLE--KELA 209

                        90       100       110
                ....*....|....*....|....*....|
gi 14195599 190 TLKQMNEQLQAENRALTRVVARLSESIESS 219
Cdd:COG4942 210 ELAAELAELQQEAEELEALIARLEAEAAAA 239
 
Name Accession Description Interval E-value
PRKG1_interact pfam15898
cGMP-dependent protein kinase interacting domain; This domain is found at the C-terminus of ...
 107-214 1.07e-30

cGMP-dependent protein kinase interacting domain; This domain is found at the C-terminus of protein phosphatase 1 regulatory subunits 12A, 12B and 12C. In protein phosphatase 1 regulatory subunit 12A it has been found to bind to cGMP-dependent protein kinase 1 via a leucine zipper motif located at the C-terminus of this domain.


Pssm-ID: 464927 [Multi-domain]  Cd Length: 102  Bit Score: 108.93  E-value: 1.07e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14195599   107 DYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEmknlhqLK 186
Cdd:pfam15898   1 DYKKLYEEELQENERLKRKLQDAQQELAELKSQLERLTQQRQESFSDRSSLLETEKREKRALERKISEMEEE------LK 74

                          90       100
                  ....*....|....*....|....*...
gi 14195599   187 QIQTLKQMNEQLQAENRALTRVVARLSE 214
Cdd:pfam15898  75 VLEDLRAENQRLKDENGALIRVISKLSK 102
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 126-204 9.33e-04

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 39.93  E-value: 9.33e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14195599   126 LQEAQLELADIKSKLEKVAQQKQEktsdRSSVLEMEKRERRALERKMSEMEEEMKNLHQlkQIQTLKQMNEQLQAENRA 204
Cdd:PRK11448  144 LHALQQEVLTLKQQLELQAREKAQ----SQALAEAQQQELVALEGLAAELEEKQQELEA--QLEQLQEKAAETSQERKQ 216
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 110-219 4.65e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 37.44  E-value: 4.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14195599 110 KLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEktsdrssVLEMEKRERRALERKMSEMEEEMKNLHqlKQIQ 189
Cdd:COG4942 139 QYLKYLAPARREQAEELRADLAELAALRAELEAERAELEA-------LLAELEEERAALEALKAERQKLLARLE--KELA 209

                        90       100       110
                ....*....|....*....|....*....|
gi 14195599 190 TLKQMNEQLQAENRALTRVVARLSESIESS 219
Cdd:COG4942 210 ELAAELAELQQEAEELEALIARLEAEAAAA 239
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 113-205 8.03e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 37.11  E-value: 8.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14195599  113 ESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQE-KTSDRSSVLEMEKRERRALERKMSEMEEEMKNLHQLKQIQTL 191
Cdd:PRK00409 523 ASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKlQEEEDKLLEEAEKEAQQAIKEAKKEADEIIKELRQLQKGGYA 602

                         90
                 ....*....|....
gi 14195599  192 KQMNEQLQAENRAL 205
Cdd:PRK00409 603 SVKAHELIEARKRL 616
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 106-222 8.42e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 36.04  E-value: 8.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14195599   106 RDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEME------KRERRALERKMSEMEEEM 179
Cdd:pfam13851  43 ERNEKLMSEIQQENKRLTEPLQKAQEEVEELRKQLENYEKDKQSLKNLKARLKVLEkelkdlKWEHEVLEQRFEKVERER 122

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 14195599   180 KNLHQlKQIQTLKQMNEQLQAENRALTRVVARLSESIESSDTQ 222
Cdd:pfam13851 123 DELYD-KFEAAIQDVQQKTGLKNLLLEKKLQALGETLEKKEAQ 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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