NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|21359972|ref|NP_115514|]
View 

kelch repeat and BTB domain-containing protein 7 [Homo sapiens]

Protein Classification

kelch-like protein; Kelch-like protein 36( domain architecture ID 13033276)

kelch-like protein may act as substrate adaptors for Cullin 3 ubiquitin ligases; Kelch-like protein 36 (KLHL36) is a probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-178 2.66e-88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 272.08  E-value: 2.66e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  37 PEELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHD 116
Cdd:cd18273   1 PEELEDAAHARALLAQLKSFYDARLLTDVTIEVNGPGSGPGSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHD 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21359972 117 VDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILK 178
Cdd:cd18273  81 VDSESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGILK 142
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 168-270 5.95e-55

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


:

Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 182.70  E-value: 5.95e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKqlsrMGSIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18482   1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQ----QLLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWI 76

                        90       100
                ....*....|....*....|...
gi 21359972 248 EAAAKERGPSAAEVFKCVRWMHF 270
Cdd:cd18482  77 EANLKERAASAAEVLKCVRWQHF 99
PHA03098 super family cl33709
kelch-like protein; Provisional
 55-544 1.56e-31

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 129.50  E-value: 1.56e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972   55 SFYDARLlCDVTIEVVTpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQqasVTMHDvDAESFEVLVDYCYTGRV 134
Cdd:PHA03098   3 SFELQKF-CDESIIIVN------GGGIIKVHKIILSSSSEYFKKMFKNNFKENE---INLNI-DYDSFNEVIKYIYTGKI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  135 SLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLsrmgsIREETL 214
Cdd:PHA03098  72 NITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELI-----YNDPDF 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  215 ADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKP-----IVKK 289
Cdd:PHA03098 147 IYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKLKRWKLRIkkkkiVFNK 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  290 YCLDVI-EGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEM------------VIFF------- 349
Cdd:PHA03098 227 RCIKIIySKKYNLNKILPRSSTFGSIIYIHITMSIFTYNYITNYSPLSEINTIIDIHyvycfgsvvlnnVIYFiggmnkn 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  350 GHPRDPFLCYDPYSGDIYTMPSPLtsfaHTKTVTSSAVCvspDHDIYL-----AAQPRKDLWVYKPAQNSWQQLADRLLC 424
Cdd:PHA03098 307 NLSVNSVVSYDTKTKSWNKVPELI----YPRKNPGVTVF---NNRIYViggiyNSISLNTVESWKPGESKWREEPPLIFP 379

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  425 REGMDVAYLNGYIYILGGRDpITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNS----------KRM 494
Cdd:PHA03098 380 RYNPCVVNVNNLIYVIGGIS-KNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGisyidnikvyNIV 458

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 21359972  495 LCYDPSHNMWLNCASLKRSDFQEA-CVFNDEIYCICDIPVMK------VYNPARGEW 544
Cdd:PHA03098 459 ESYNPVTNKWTELSSLNFPRINASlCIFNNKIYVVGGDKYEYyineieVYDDKTNTW 515
 
Name Accession Description Interval E-value
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-178 2.66e-88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 272.08  E-value: 2.66e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  37 PEELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHD 116
Cdd:cd18273   1 PEELEDAAHARALLAQLKSFYDARLLTDVTIEVNGPGSGPGSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHD 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21359972 117 VDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILK 178
Cdd:cd18273  81 VDSESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGILK 142
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 168-270 5.95e-55

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 182.70  E-value: 5.95e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKqlsrMGSIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18482   1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQ----QLLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWI 76

                        90       100
                ....*....|....*....|...
gi 21359972 248 EAAAKERGPSAAEVFKCVRWMHF 270
Cdd:cd18482  77 EANLKERAASAAEVLKCVRWQHF 99
PHA03098 PHA03098
kelch-like protein; Provisional
 55-544 1.56e-31

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 129.50  E-value: 1.56e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972   55 SFYDARLlCDVTIEVVTpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQqasVTMHDvDAESFEVLVDYCYTGRV 134
Cdd:PHA03098   3 SFELQKF-CDESIIIVN------GGGIIKVHKIILSSSSEYFKKMFKNNFKENE---INLNI-DYDSFNEVIKYIYTGKI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  135 SLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLsrmgsIREETL 214
Cdd:PHA03098  72 NITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELI-----YNDPDF 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  215 ADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKP-----IVKK 289
Cdd:PHA03098 147 IYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKLKRWKLRIkkkkiVFNK 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  290 YCLDVI-EGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEM------------VIFF------- 349
Cdd:PHA03098 227 RCIKIIySKKYNLNKILPRSSTFGSIIYIHITMSIFTYNYITNYSPLSEINTIIDIHyvycfgsvvlnnVIYFiggmnkn 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  350 GHPRDPFLCYDPYSGDIYTMPSPLtsfaHTKTVTSSAVCvspDHDIYL-----AAQPRKDLWVYKPAQNSWQQLADRLLC 424
Cdd:PHA03098 307 NLSVNSVVSYDTKTKSWNKVPELI----YPRKNPGVTVF---NNRIYViggiyNSISLNTVESWKPGESKWREEPPLIFP 379

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  425 REGMDVAYLNGYIYILGGRDpITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNS----------KRM 494
Cdd:PHA03098 380 RYNPCVVNVNNLIYVIGGIS-KNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGisyidnikvyNIV 458

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 21359972  495 LCYDPSHNMWLNCASLKRSDFQEA-CVFNDEIYCICDIPVMK------VYNPARGEW 544
Cdd:PHA03098 459 ESYNPVTNKWTELSSLNFPRINASlCIFNNKIYVVGGDKYEYyineieVYDDKTNTW 515
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 53-164 1.42e-25

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 101.57  E-value: 1.42e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972    53 LKSFYDARLLCDVTIEVVtpgsgpgtGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTG 132
Cdd:pfam00651   1 LNELREQGELCDVTLVVG--------DKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTG 72

                          90       100       110
                  ....*....|....*....|....*....|..
gi 21359972   133 RVsLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:pfam00651  73 KL-ISEENVDDLLAAADKLQIPSLVDKCEEFL 103
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 64-168 7.21e-24

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 96.22  E-value: 7.21e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972     64 DVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQR 143
Cdd:smart00225   1 DVTLVV--------GGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEE 72

                           90       100
                   ....*....|....*....|....*
gi 21359972    144 LYAASDMLQLEYVREACASFLARRL 168
Cdd:smart00225  73 LLELADYLQIPGLVELCEEFLLKLL 97
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
369-601 6.90e-18

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 84.44  E-value: 6.90e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 369 MPSPLtsfahtktvtSSAVCVSPDHDIYLA-----AQPRKDLWVYKPAQNSWQQLADrlLCREGMD---VAYLNGYIYIL 440
Cdd:COG3055   9 LPTPR----------SEAAAALLDGKVYVAgglsgGSASNSFEVYDPATNTWSELAP--LPGPPRHhaaAVAQDGKLYVF 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 441 GGRD--PITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAV-------NSKRMLCYDPSHNMWLNCASL- 510
Cdd:COG3055  77 GGFTgaNPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVggwddggNVAWVEVYDPATGTWTQLAPLp 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 511 -KRSDFQEACVFNDEIYCI--CDipvmkvYNPARGEWRRISNIPldSETHNYQIVNHDQKLLLITSTtpqwKKNRVTVYE 587
Cdd:COG3055 157 tPRDHLAAAVLPDGKILVIggRN------GSGFSNTWTTLAPLP--TARAGHAAAVLGGKILVFGGE----SGFSDEVEA 224

                       250
                ....*....|....
gi 21359972 588 YDTREDQWINIGTM 601
Cdd:COG3055 225 YDPATNTWTALGEL 238
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 173-274 2.62e-17

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 77.77  E-value: 2.62e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972    173 CTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREetladLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAK 252
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLE-----LPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPE 75

                           90       100
                   ....*....|....*....|..
gi 21359972    253 ERGPSAAEVFKCVRWMHFTEED 274
Cdd:smart00875  76 KRREHLPELLEHVRLPLLSPDY 97
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 173-267 3.00e-15

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 71.81  E-value: 3.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972   173 CTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMgsirEETLaDLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAK 252
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKS----EEFL-ELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVE 75

                          90
                  ....*....|....*
gi 21359972   253 ERGPSAAEVFKCVRW 267
Cdd:pfam07707  76 RRKKHLPELLSAVRL 90
PHA02790 PHA02790
Kelch-like protein; Provisional
 85-246 8.15e-07

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 51.97  E-value: 8.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972   85 NRNVLAAACPYFKSMFTGgMYESQQASVTM--HDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACAS 162
Cdd:PHA02790  36 NSTILKKLSPYFRTHLRQ-KYTKNKDPVTRvcLDLDIHSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCIN 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  163 FLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLsrmgsiREETLADLTLAQLLAVLRLDSLDIESERTVCHV 242
Cdd:PHA02790 115 FILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLEL------EDDIIDNFDYLSMKLILESDELNVPDEDYVVDF 188


                 ....
gi 21359972  243 AVQW 246
Cdd:PHA02790 189 VIKW 192
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 425-471 6.04e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 40.67  E-value: 6.04e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 21359972   425 REGMDVAYLNGYIYILGGRDPITGvkLKEVECYSVQRNQWALVAPVP 471
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQS--LNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
437-472 5.50e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.23  E-value: 5.50e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 21359972    437 IYILGGRDPitGVKLKEVECYSVQRNQWALVAPVPH 472
Cdd:smart00612   2 IYVVGGFDG--GQRLKSVEVYDPETNKWTPLPSMPT 35
 
Name Accession Description Interval E-value
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-178 2.66e-88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 272.08  E-value: 2.66e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  37 PEELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHD 116
Cdd:cd18273   1 PEELEDAAHARALLAQLKSFYDARLLTDVTIEVNGPGSGPGSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHD 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21359972 117 VDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILK 178
Cdd:cd18273  81 VDSESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGILK 142
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 168-270 5.95e-55

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 182.70  E-value: 5.95e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKqlsrMGSIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18482   1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQ----QLLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWI 76

                        90       100
                ....*....|....*....|...
gi 21359972 248 EAAAKERGPSAAEVFKCVRWMHF 270
Cdd:cd18482  77 EANLKERAASAAEVLKCVRWQHF 99
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-173 2.41e-37

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 135.11  E-value: 2.41e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  53 LKSFYDARLLCDVTIEVvtpGSgpgtgRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTG 132
Cdd:cd18238   6 LHQFYENGELCDVTLKV---GE-----KSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTG 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21359972 133 RVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18238  78 KLTLTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNC 118
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-176 1.20e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 133.57  E-value: 1.20e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  42 DTAHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAES 121
Cdd:cd18274   2 DPLHACSILQQLKAMYDEGQLTDIVVEV-------DHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAES 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 21359972 122 FEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAI 176
Cdd:cd18274  75 MHLVLDYAYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-173 4.90e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 131.76  E-value: 4.90e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18256   3 HASLILAQLNKLRGQHEFCDVQLQV--------GMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHI 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18256  75 LLDFIYTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNC 123
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-173 1.43e-34

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 127.58  E-value: 1.43e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  42 DTAHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAES 121
Cdd:cd18250   1 DPAHALHLLRGLSELRAERKFFDVTLCA--------GGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEI 72

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 21359972 122 FEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18250  73 LGLLLDFSYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
PHA03098 PHA03098
kelch-like protein; Provisional
 55-544 1.56e-31

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 129.50  E-value: 1.56e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972   55 SFYDARLlCDVTIEVVTpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQqasVTMHDvDAESFEVLVDYCYTGRV 134
Cdd:PHA03098   3 SFELQKF-CDESIIIVN------GGGIIKVHKIILSSSSEYFKKMFKNNFKENE---INLNI-DYDSFNEVIKYIYTGKI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  135 SLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLsrmgsIREETL 214
Cdd:PHA03098  72 NITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELI-----YNDPDF 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  215 ADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKP-----IVKK 289
Cdd:PHA03098 147 IYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKLKRWKLRIkkkkiVFNK 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  290 YCLDVI-EGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEM------------VIFF------- 349
Cdd:PHA03098 227 RCIKIIySKKYNLNKILPRSSTFGSIIYIHITMSIFTYNYITNYSPLSEINTIIDIHyvycfgsvvlnnVIYFiggmnkn 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  350 GHPRDPFLCYDPYSGDIYTMPSPLtsfaHTKTVTSSAVCvspDHDIYL-----AAQPRKDLWVYKPAQNSWQQLADRLLC 424
Cdd:PHA03098 307 NLSVNSVVSYDTKTKSWNKVPELI----YPRKNPGVTVF---NNRIYViggiyNSISLNTVESWKPGESKWREEPPLIFP 379

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  425 REGMDVAYLNGYIYILGGRDpITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNS----------KRM 494
Cdd:PHA03098 380 RYNPCVVNVNNLIYVIGGIS-KNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGisyidnikvyNIV 458

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 21359972  495 LCYDPSHNMWLNCASLKRSDFQEA-CVFNDEIYCICDIPVMK------VYNPARGEW 544
Cdd:PHA03098 459 ESYNPVTNKWTELSSLNFPRINASlCIFNNKIYVVGGDKYEYyineieVYDDKTNTW 515
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-167 1.89e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 115.46  E-value: 1.89e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  52 QLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYT 131
Cdd:cd18247   9 VMEEIRRQGKLCDVTLKV--------GDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYS 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 21359972 132 GRVSLSEANVQRLYAASDMLQLEYVREACASFLARR 167
Cdd:cd18247  81 GRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-173 4.42e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 114.85  E-value: 4.42e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18242   4 HAKSILNTMNSLRKSNTLCDVTLRV--------EGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEI 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18242  76 LLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 62-151 8.87e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 112.65  E-value: 8.87e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  62 LCDVTIEVVtpgsgpgtGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANV 141
Cdd:cd18186   1 LCDVTLVVG--------GREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENV 72

                        90
                ....*....|
gi 21359972 142 QRLYAASDML 151
Cdd:cd18186  73 EELLAAADKL 82
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-173 5.25e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 111.84  E-value: 5.25e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  42 DTAHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAES 121
Cdd:cd18252   1 DSSHPADFLDAFRTFYLDGLFTDITLQC-------ASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDI 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 21359972 122 FEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18252  74 LEALVNYVYTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNC 125
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-173 2.71e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 109.85  E-value: 2.71e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpGTGRLFScNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18249   6 HPRQTLEAINLLRKHRELCDVVLVV-------GAKKIYA-HRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMEL 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18249  78 LIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNC 126
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-169 8.12e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 108.28  E-value: 8.12e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  44 AHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFE 123
Cdd:cd18235   3 QHTQKAFDVMNELRKQNLLCDVILVA--------DGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALL 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 21359972 124 VLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLD 169
Cdd:cd18235  75 LLIDYVYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQLH 120
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-173 8.49e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 109.31  E-value: 8.49e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  21 RPKRISKPSVSAFFtgpeeLKDTAHSAALLAQLKSFYDARLLCDVtieVVTPGSgpgtgRLFSCNRNVLAAACPYFKSMF 100
Cdd:cd18267   4 RKSRASSGSMNIYL-----FHKSSYADSVLTHLNLLRQQRLFTDV---LLHAGN-----RSFPCHRAVLAACSRYFEAMF 70

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21359972 101 TGGMYESQQASVTMHD-VDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18267  71 SGGLKESQDSEVNFHDsIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNC 144
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 62-173 9.31e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 107.45  E-value: 9.31e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  62 LCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANV 141
Cdd:cd18234   1 LCDVILIA--------GDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNV 72

                        90       100       110
                ....*....|....*....|....*....|..
gi 21359972 142 QRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18234  73 ESLLATACLLQLSEVVEACCGFLMKQLHPSNC 104
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-173 6.63e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 106.03  E-value: 6.63e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18237   4 LLADFMGVMNNMRKQKTLCDVILIV--------EGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIEL 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18237  76 LVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNC 124
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-173 1.40e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 104.78  E-value: 1.40e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18255   1 HSVTLLQGLNALRAKGQLLDVTLIA--------DGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKH 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18255  73 ILDFAYTSELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-177 2.13e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 104.70  E-value: 2.13e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  42 DTAHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAES 121
Cdd:cd18270   6 NTEYAVSLLEQLKFFYEQQLLTDIVLIV--------EGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAAT 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21359972 122 FEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAIL 177
Cdd:cd18270  78 LQIIITYAYTGNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLL 133
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-173 5.63e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 103.76  E-value: 5.63e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  44 AHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFE 123
Cdd:cd18259  14 SHPQSILDGLQTLRSNPKLSDVTLLV--------GGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVME 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 21359972 124 VLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18259  86 SLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNC 135
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-173 6.48e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 103.33  E-value: 6.48e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  41 KDTAHSAALLAQLKSFYDARLLCDVTIevvtpgsgPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE 120
Cdd:cd18268   2 KDQDLSSELLRQLNSLRQERILTDVIL--------CTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSD 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 21359972 121 SFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18268  74 VLDQIVDYVYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENC 126
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 53-164 1.42e-25

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 101.57  E-value: 1.42e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972    53 LKSFYDARLLCDVTIEVVtpgsgpgtGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTG 132
Cdd:pfam00651   1 LNELREQGELCDVTLVVG--------DKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTG 72

                          90       100       110
                  ....*....|....*....|....*....|..
gi 21359972   133 RVsLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:pfam00651  73 KL-ISEENVDDLLAAADKLQIPSLVDKCEEFL 103
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-169 3.09e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 101.08  E-value: 3.09e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18257   1 HSEQLLQGLNLLRQHHELCDVVLRV--------GDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQA 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLD 169
Cdd:cd18257  73 IVEYAYTGTVFISQATVESLLPAANLLQIKLVLKECCDFLESQLD 117
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-173 4.46e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 100.68  E-value: 4.46e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18253   1 HSESILQVFNEFRDSRLFTDVIICV--------EGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDC 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18253  73 FLQYVYTGKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-173 7.63e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 100.09  E-value: 7.63e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  44 AHSAALLAQLKSFYDARLLCDVTIevvtpGSGpgtGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHD-VDAESF 122
Cdd:cd18254   4 SHPDCVLTHLNTLRKQCMFTDVTL-----WAG---NRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDsLHPEVL 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 21359972 123 EVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18254  76 ELLLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNC 126
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-175 9.00e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 99.85  E-value: 9.00e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  43 TAHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESF 122
Cdd:cd18265   4 PCHAERILQVLNAYRRSGTFTDVVLLV--------DGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAM 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 21359972 123 EVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTA 175
Cdd:cd18265  76 EVLLDYMYGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-169 6.17e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 97.45  E-value: 6.17e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  59 ARLLCDVTIEVvtpgSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSE 138
Cdd:cd18248  18 SQQLCDVTLKV----KYQDPKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEFAYTASISVGE 93

                        90       100       110
                ....*....|....*....|....*....|.
gi 21359972 139 ANVQRLYAASDMLQLEYVREACASFLARRLD 169
Cdd:cd18248  94 KCVLHVLPGAVMYQMDSVVKACCDFLEQQLD 124
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 64-168 7.21e-24

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 96.22  E-value: 7.21e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972     64 DVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQR 143
Cdd:smart00225   1 DVTLVV--------GGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEE 72

                           90       100
                   ....*....|....*....|....*
gi 21359972    144 LYAASDMLQLEYVREACASFLARRL 168
Cdd:smart00225  73 LLELADYLQIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-173 4.56e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 94.70  E-value: 4.56e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  56 FYDARL---LCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTG 132
Cdd:cd18240   8 FNELRLegkLCDVVIRV--------NGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTR 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21359972 133 RVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18240  80 TVPITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-176 6.36e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 94.49  E-value: 6.36e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIevvtpgsgPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18276   4 HSLTLLDQLNRMKELAELTDVVL--------VAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSI 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAI 176
Cdd:cd18276  76 ILNYMYSSDLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-168 7.50e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 94.40  E-value: 7.50e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  44 AHSAALLAQLKSFYDARLLCDVTI---EVVtpgsgpgtgrlFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE 120
Cdd:cd18339   3 AHMKKAFKVMNELRSKQLLCDVTIvaeDVE-----------IEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQ 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 21359972 121 SFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRL 168
Cdd:cd18339  72 TLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQL 119
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-176 1.01e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 94.13  E-value: 1.01e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  79 GRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVRE 158
Cdd:cd18340  36 EKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAAANMFQIPSIFT 115

                        90
                ....*....|....*...
gi 21359972 159 ACASFLARRLDLTNCTAI 176
Cdd:cd18340 116 VCVSFLQKRLCLSNCLAI 133
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-173 2.50e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 92.95  E-value: 2.50e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  43 TAHSAALLAQLKSFYDARLLCDVTIevvTPGSGPGTgrlFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESF 122
Cdd:cd18239   4 NTHSSVVLQGFDQLRGEGLLCDVTL---VPGDGDET---FPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGL 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 21359972 123 EVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18239  78 KNIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-169 3.17e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 93.17  E-value: 3.17e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  61 LLCDVTIEVVTpgsgpgtgRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEAN 140
Cdd:cd18246  38 LLCDIVLHVGT--------KEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGN 109

                        90       100
                ....*....|....*....|....*....
gi 21359972 141 VQRLYAASDMLQLEYVREACASFLARRLD 169
Cdd:cd18246 110 VQTLLPAASLLQLNGVRDACCKFLLSQLD 138
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-173 7.46e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 91.82  E-value: 7.46e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18271   7 HGQQILSVLQNFREQNAFFDFNIIV--------KDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKA 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18271  79 FLDYAYTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNC 127
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-168 1.19e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 90.90  E-value: 1.19e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  61 LLCDVTI--EVVTpgsgpgtgrlFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSE 138
Cdd:cd18338  20 LLCDVTIvaEDVE----------IAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTE 89

                        90       100       110
                ....*....|....*....|....*....|
gi 21359972 139 ANVQRLYAASDMLQLEYVREACASFLARRL 168
Cdd:cd18338  90 ENVQVLLPAAGLLQLQDVKKTCCEFLESQL 119
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-176 2.55e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 90.01  E-value: 2.55e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18306   1 HPESVLAKLNALRKNRQFCDVILQV--------GGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEV 72

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAI 176
Cdd:cd18306  73 LVNYAYTSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-173 3.10e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 89.91  E-value: 3.10e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  42 DTAHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAES 121
Cdd:cd18236   4 DTGLSLVLQNGLENLRLENSLTDVILCV--------DSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAET 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 21359972 122 FEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18236  76 MQILLDYTYTSKVLITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENC 127
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-176 5.56e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 89.39  E-value: 5.56e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  79 GRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVRE 158
Cdd:cd18269  36 DKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQDIFALASRFQIPSIFT 115

                        90
                ....*....|....*...
gi 21359972 159 ACASFLARRLDLTNCTAI 176
Cdd:cd18269 116 VCVSYLQKRLSLSNCLAI 133
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-177 4.37e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 86.87  E-value: 4.37e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  40 LKDTAHSAALLAQLKSF-YDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVD 118
Cdd:cd18272   9 FTDRSHSSRVAQSIMDLcLEDGLFADVTISV--------EGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVS 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21359972 119 AESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAIL 177
Cdd:cd18272  81 ESVFQLLVDYIYHGTVKLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQVM 139
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-164 4.16e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 83.16  E-value: 4.16e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  49 LLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMF--TGGMYESQQASVTMHDVDAESFEVLV 126
Cdd:cd18245   1 LLRALNSFREEPHLCDATLVV--------GGEEIPVQKNVLAAASPYFRAKLnyNPPKDDGSTYKIELEGISVEVMEEIL 72

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 21359972 127 DYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18245  73 DYIYTGQIKLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-176 1.72e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 82.02  E-value: 1.72e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpGTGRLfSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18336   2 HAEQTFRKMENYLQHKQLCDVLLIA-------GNLKI-PAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKA 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAI 176
Cdd:cd18336  74 LVHYAYTGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-164 6.23e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 79.60  E-value: 6.23e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  51 AQLKSFYDARLLCDVTIEVvtpgsGPgTGRLFSCNRNVLAAACPYFKSMF-TGGMYESQQASVTMHDVDAESFEVLVDYC 129
Cdd:cd18294   3 ADMKSLINNPEFSDVKFLV-----GP-ERQEIFAHKCILAARCEVFRAMFlTGPQKESTQSPLVLSDIEPEVFRAVLEFI 76

                        90       100       110
                ....*....|....*....|....*....|....*
gi 21359972 130 YTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18294  77 YTNCVTLSNHTVIEVLAAAVEYGLDELRKLCERFI 111
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
369-601 6.90e-18

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 84.44  E-value: 6.90e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 369 MPSPLtsfahtktvtSSAVCVSPDHDIYLA-----AQPRKDLWVYKPAQNSWQQLADrlLCREGMD---VAYLNGYIYIL 440
Cdd:COG3055   9 LPTPR----------SEAAAALLDGKVYVAgglsgGSASNSFEVYDPATNTWSELAP--LPGPPRHhaaAVAQDGKLYVF 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 441 GGRD--PITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAV-------NSKRMLCYDPSHNMWLNCASL- 510
Cdd:COG3055  77 GGFTgaNPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVggwddggNVAWVEVYDPATGTWTQLAPLp 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 511 -KRSDFQEACVFNDEIYCI--CDipvmkvYNPARGEWRRISNIPldSETHNYQIVNHDQKLLLITSTtpqwKKNRVTVYE 587
Cdd:COG3055 157 tPRDHLAAAVLPDGKILVIggRN------GSGFSNTWTTLAPLP--TARAGHAAAVLGGKILVFGGE----SGFSDEVEA 224

                       250
                ....*....|....
gi 21359972 588 YDTREDQWINIGTM 601
Cdd:COG3055 225 YDPATNTWTALGEL 238
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-138 1.27e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 79.20  E-value: 1.27e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18287   5 HVHFLSEDIGALFLNEEYSDVTFVV--------EEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKA 76

                        90
                ....*....|....
gi 21359972 125 LVDYCYTGRVSLSE 138
Cdd:cd18287  77 LLKYIYTGRLTLTD 90
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-172 1.44e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 79.09  E-value: 1.44e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  41 KDTAHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE 120
Cdd:cd18251   2 RSVAHSQALLDGLVALRDSGILFDVVLVV--------EGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYN 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 21359972 121 SFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTN 172
Cdd:cd18251  74 AMCKILDFIYTSELELSLDNVQETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 173-274 2.62e-17

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 77.77  E-value: 2.62e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972    173 CTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREetladLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAK 252
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLE-----LPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPE 75

                           90       100
                   ....*....|....*....|..
gi 21359972    253 ERGPSAAEVFKCVRWMHFTEED 274
Cdd:smart00875  76 KRREHLPELLEHVRLPLLSPDY 97
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 50-173 3.92e-17

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 77.93  E-value: 3.92e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  50 LAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYC 129
Cdd:cd18263   1 LQSIEGLWEKGVGCDVQLEA--------DGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFA 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 21359972 130 YTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18263  73 YSGILHLSWENLFEATCTALQLQISGALALCLDFLQREISPARC 116
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-173 3.99e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 78.36  E-value: 3.99e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  61 LLCDVTIEVvtpgsGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHD------VDAESFEVLVDYCYTGRV 134
Cdd:cd18241  22 LFCDITLAF-----GGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKwssepgPDPDTVEAVIQYMYTGRI 96

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 21359972 135 SLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18241  97 RVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-171 8.10e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 77.02  E-value: 8.10e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  43 TAHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHD-VDAES 121
Cdd:cd18230   2 TSHYRHLLRELNEQRQHGILCDVCIIV--------EGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDiVTAQG 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 21359972 122 FEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLT 171
Cdd:cd18230  74 FKAIIDFMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDIS 123
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-164 1.71e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 76.13  E-value: 1.71e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18326   8 HSSDILSSLNEQRTQGLLCDVVILV--------EGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTA 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18326  80 LLDFAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
350-587 1.78e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 80.20  E-value: 1.78e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 350 GHPRDPFLCYDPYSGDIYTMPS-PLTSFAHtktvtssAVCVSPDHDIYLA---------AQPRKDLWVYKPAQNSWQQLA 419
Cdd:COG3055  34 GSASNSFEVYDPATNTWSELAPlPGPPRHH-------AAAVAQDGKLYVFggftganpsSTPLNDVYVYDPATNTWTKLA 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 420 DRLLCREGMDVAYLNGYIYILGGRDPitGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQN-YLYAV---NSkrml 495
Cdd:COG3055 107 PMPTPRGGATALLLDGKIYVVGGWDD--GGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDgKILVIggrNG---- 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 496 cyDPSHNMWLNCASLKRSDFQEACV--------------FNDEIYcicdipvmkVYNPARGEWRRISNIPLDSetHNYQI 561
Cdd:COG3055 181 --SGFSNTWTTLAPLPTARAGHAAAvlggkilvfggesgFSDEVE---------AYDPATNTWTALGELPTPR--HGHAA 247

                       250       260
                ....*....|....*....|....*..
gi 21359972 562 VNHDQKLLLIT-STTPQWKKNRVTVYE 587
Cdd:COG3055 248 VLTDGKVYVIGgETKPGVRTPLVTSAE 274
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 80-160 3.97e-16

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 74.30  E-value: 3.97e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  80 RLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREA 159
Cdd:cd18314  16 RKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKYQVPDLEKL 95


                .
gi 21359972 160 C 160
Cdd:cd18314  96 C 96
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-176 5.19e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 75.10  E-value: 5.19e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVtieVVTPGSgpgtgRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18337   6 HAEQTFKKMENYLRHKQLCDV---VLVAGD-----RRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWA 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAI 176
Cdd:cd18337  78 LVQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-176 9.79e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 74.11  E-value: 9.79e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  80 RLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREA 159
Cdd:cd18341  37 KSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDLNDGNVQDIFALASRFQIPSVFTV 116

                        90
                ....*....|....*..
gi 21359972 160 CASFLARRLDLTNCTAI 176
Cdd:cd18341 117 CVTYLQKRLSPANCLAI 133
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 173-267 3.00e-15

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 71.81  E-value: 3.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972   173 CTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMgsirEETLaDLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAK 252
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKS----EEFL-ELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVE 75

                          90
                  ....*....|....*
gi 21359972   253 ERGPSAAEVFKCVRW 267
Cdd:pfam07707  76 RRKKHLPELLSAVRL 90
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-164 9.60e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 71.05  E-value: 9.60e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18198   8 HSSEILSGLNEQRTQGLLCDVVILV--------QGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTA 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18198  80 LLEFAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEIL 119
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-176 9.64e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 71.23  E-value: 9.64e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18335   2 HAEQTFRKMESYLKQQQLCDVILIA--------GNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWD 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAI 176
Cdd:cd18335  74 LVQFAYTGCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-164 1.59e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 70.24  E-value: 1.59e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  43 TAHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDV-DAES 121
Cdd:cd18329   2 SSHQSRLLQQLDEQRKQELFCDCSILV--------EGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVfSPDT 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 21359972 122 FEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18329  74 FTIILDFVYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-172 2.28e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 70.00  E-value: 2.28e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  79 GRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVS---LSEANVQRLYAASDMLQLEY 155
Cdd:cd18297  21 GRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVEsldVAQDDALELLRAASFFQLDG 100

                        90
                ....*....|....*..
gi 21359972 156 VREACASFLARRLDLTN 172
Cdd:cd18297 101 LKRHCEILLSQQIDLDN 117
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-172 6.97e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 68.84  E-value: 6.97e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  35 TGPEELKDTAHSAALLAQLKSFYDARLLCDVTIevvtpgsgPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTM 114
Cdd:cd18261   1 TGQRLCQSKSHKDAVLAALNQQRNDGILCDITL--------VAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNL 72

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21359972 115 HDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTN 172
Cdd:cd18261  73 HGVTSLGLKQALDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFN 130
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-173 1.11e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 68.67  E-value: 1.11e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  44 AHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFE 123
Cdd:cd18264  10 SHGEAVLSQYQSLRAEGFLCDVVLEA--------EGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQ 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 21359972 124 VLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18264  82 RVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENC 131
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-177 1.31e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 68.44  E-value: 1.31e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18244  13 HDTSVSAGFRALYEEGLLLDVTLVI--------EDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSH 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAIL 177
Cdd:cd18244  85 VLQFMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNCAEIM 137
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-164 1.50e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 67.96  E-value: 1.50e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGG-------MYESQQASVTMHDV 117
Cdd:cd18228   2 HSQELLGKLNSLRNEGHFCDVTIRV--------QDKIFRAHKVVLAACSDFFRSKLVGQasprlvlVSPAGKCVLDLHHV 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 21359972 118 DAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18228  74 TVTGFAPLLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFM 120
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 168-266 2.65e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 66.04  E-value: 2.65e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFkqlsrMGSIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18483   1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKF-----LSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWF 75

                        90       100
                ....*....|....*....|
gi 21359972 248 EAAAKERGPSAAEVF-KCVR 266
Cdd:cd18483  76 EHEQSKREMHLPEIFaKCIR 95
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-164 3.44e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 66.29  E-value: 3.44e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDV-DAESFE 123
Cdd:cd18199   1 HQSRLLGQLNEQRKQDFFCDCSIIV--------EGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVfSSDAFS 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21359972 124 VLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18199  73 IILDFVYSGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-163 6.02e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 65.55  E-value: 6.02e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMyesqQASVTMHDVDAESFEV 124
Cdd:cd18232   1 HSVKVLQALNKQREEGQYCDATLDV--------GGRVFKAHWSVLACCSHFFQSLYGDGT----SGSVVLPESFAEVFGL 68

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASF 163
Cdd:cd18232  69 LLDFFYTGELALTRENRDRVLLAAKELRVPEAVELCQRF 107
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 54-168 8.98e-13

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 64.95  E-value: 8.98e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  54 KSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGR 133
Cdd:cd18300   1 KLFLNKGLFSDVTFIV--------EDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQ 72

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 21359972 134 VSLSEAN-VQRLYAASDMLQLEYVREACASFLARRL 168
Cdd:cd18300  73 APILEDGdCVGLIVLANRLCLPRLVALCEQYIVKEL 108
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 79-151 2.78e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 62.68  E-value: 2.78e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21359972  79 GRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDML 151
Cdd:cd01165   7 GEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 64-166 5.02e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 63.43  E-value: 5.02e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  64 DVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSL-SEANVQ 142
Cdd:cd18286  19 DITIKV--------DGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLpDDVNLG 90

                        90       100
                ....*....|....*....|....
gi 21359972 143 RLYAASDMLQLEYVREACASFLAR 166
Cdd:cd18286  91 ELLSLADMYGLDGLKDVVAYTLRR 114
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-164 6.49e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 63.33  E-value: 6.49e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHD-------V 117
Cdd:cd18327   8 HSSELLSCLNEQRRAGLLCDLTIKT--------RGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAGGGQdvceldfV 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 21359972 118 DAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18327  80 GPEALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADIL 126
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-172 1.19e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 62.33  E-value: 1.19e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  79 GRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVRE 158
Cdd:cd18343  30 GQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADNLLAAADKYALERLKV 109

                        90
                ....*....|....
gi 21359972 159 ACASFLARRLDLTN 172
Cdd:cd18343 110 MCEEALCNNLSVEN 123
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-173 1.23e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 62.30  E-value: 1.23e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  79 GRLFSCNRNVLAAACPYFKSMFTGGMYES---QQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEY 155
Cdd:cd18258  26 GKEFEVHQNVLASCSLYFKDLIKRSSRDSgggEKLELTMSNINADVLELLLEFVYTGSLIIDSANAKTLLEAANKFQFHT 105

                        90
                ....*....|....*...
gi 21359972 156 VREACASFLARRLDLTNC 173
Cdd:cd18258 106 FCKVCVSFLEKQLTASNC 123
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-172 1.34e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 62.16  E-value: 1.34e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  79 GRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVRE 158
Cdd:cd18279  27 GQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADDLLAAADKYALERLKV 106

                        90
                ....*....|....
gi 21359972 159 ACASFLARRLDLTN 172
Cdd:cd18279 107 MCEDALCSNLSVEN 120
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-160 1.98e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 61.31  E-value: 1.98e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgtGRL-FSCNRNVLAAACPYFksmftGGMYESQQASVTMHD---VDAE 120
Cdd:cd18217   1 HCEQLLERLNKQREAGFLCDCTIVI---------GQFqFKAHRNVLAAFSEYF-----GAQYKDTEDNIVFLDqsqVSAD 66

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21359972 121 SFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREAC 160
Cdd:cd18217  67 GFQKLLEFIYTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-169 1.99e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 61.51  E-value: 1.99e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  49 LLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYES-QQASVTMHDVDA-ESFEVLV 126
Cdd:cd18201   8 LLQELNEQRKKGILCDVNIVV--------SGKVFRAHKNILVAGSRFFKTLYCFTNKEScDQTTVTHLDVVAvQGFSVIL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 21359972 127 DYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLD 169
Cdd:cd18201  80 DFMYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 169-266 2.15e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 60.89  E-value: 2.15e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 169 DLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRmgsirEETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLE 248
Cdd:cd18468   1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVAR-----QEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLK 75

                        90
                ....*....|....*...
gi 21359972 249 AAAKERGPSAAEVFKCVR 266
Cdd:cd18468  76 KDPKNRKQHIAELLAVVR 93
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-164 3.55e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 60.71  E-value: 3.55e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  47 AALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHD-VDAESFEVL 125
Cdd:cd18330   3 TKLLGELNEQRKRDFFCDCSIIV--------EGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDiVTSEAFSII 74

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 21359972 126 VDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18330  75 LDFLYSGKLDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-164 4.26e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 60.64  E-value: 4.26e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  43 TAHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESF 122
Cdd:cd18331   5 TRHASDVLLNLNRLRSRDILTDVVIVV--------SREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGF 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 21359972 123 EVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18331  77 NILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-164 1.04e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 59.69  E-value: 1.04e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  41 KDTAHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMyeSQQASVTM-HDVDA 119
Cdd:cd18277   6 ESSVHSTNVLLSLNDQRKKDVLCDVTILV--------EGQRFRAHRSVLAACSSYFHSRIVGQA--DAELNITLpEEVTV 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 21359972 120 ESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18277  76 KGFEPLIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-164 1.26e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 59.26  E-value: 1.26e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  52 QLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYT 131
Cdd:cd18280   4 HFGALLESEEGADVTFNV--------DGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYK 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 21359972 132 GRV------------SLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18280  76 DELpddvepagsdssSLDTTMAQHLLAAADRYALERLRLLCESRL 120
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-163 1.71e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 58.28  E-value: 1.71e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  63 CDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYE-SQQASVT--MHDVDAESFEVLVDYCYTGRVSLSEA 139
Cdd:cd18307   2 CDVVISV--------DNHSFAAHRNVLAAVSPFVKSLISSNDMKaTDELSITidCDYLSPETVEQLLDYFYTGKIVISEK 73

                        90       100
                ....*....|....*....|....
gi 21359972 140 NVQRLYAASDMLQLEYVREACASF 163
Cdd:cd18307  74 NVEDLLKGAKYFNIPRLKDHCVDF 97
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 56-152 1.85e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 57.56  E-value: 1.85e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  56 FYDARLLCDvtievvtpgsgpgtGRLFSCNRNVLAAACPYFKSMFTGGMYeSQQASVTMHDVDAESFEVLVDYCYTGRVS 135
Cdd:cd18315   1 LVDVTLACE--------------GGSLKAHKLVLAAASPYFAALLKETPP-DEHPVIILPDVPYSELKALLDFIYTGEVN 65

                        90
                ....*....|....*..
gi 21359972 136 LSEANVQRLYAASDMLQ 152
Cdd:cd18315  66 VSQEQLESLLKLAELLQ 82
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-163 2.40e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 58.35  E-value: 2.40e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGgmyeSQQASVTMHDVD----AE 120
Cdd:cd18215   2 HASDVLLNLNRLRSRDILTDVVLVV--------GREQFRAHKTVLMACSGLFYSIFTD----QLKNNVSVINLDpeiePE 69

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 21359972 121 SFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASF 163
Cdd:cd18215  70 GFRILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-172 3.87e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 57.94  E-value: 3.87e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  53 LKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTG 132
Cdd:cd18345   9 LGLLFERSAFSDVTLCV--------GGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTG 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21359972 133 RVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTN 172
Cdd:cd18345  81 KAPNLDKMADDLLAAADKYALERLKVMCEEALCSNLSVEN 120
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-160 4.79e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 57.58  E-value: 4.79e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18328   8 HSSEVLCSLNEQRHDGLLCDVVLIV--------QDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSA 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREAC 160
Cdd:cd18328  80 ILEFAYTSTLTITTSNVKHILNAAQMLEIQCIINVC 115
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-173 5.02e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 57.52  E-value: 5.02e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIevVTpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGgmyESQQASVTMHDVDAESFEV 124
Cdd:cd18260   1 YGANLLEGLNRMRQERFLCDLTI--AT------KTKSFDVHKVVMASCSEYFRNILKK---DPSLQRVELNDISPLGLAT 69

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18260  70 VITYAYTGKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENC 118
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-160 5.27e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 57.56  E-value: 5.27e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  40 LKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGpgtgRLFSCNRNVLAAACPYFKSMFTGGM-YESQQASVTMHDVD 118
Cdd:cd18211   3 LESKSAPSNLLNEMHKLRLLGHLCDVTVQVEHQGSK----EEFSAHKAVLAASSKYFKEVFLNEKiSDGKNTNVMLNEIY 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 21359972 119 AESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREAC 160
Cdd:cd18211  79 TADFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETC 120
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 168-266 5.42e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 56.77  E-value: 5.42e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRmgsirEETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18477   1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAK-----DEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWV 75

                        90
                ....*....|....*....
gi 21359972 248 EAAAKERGPSAAEVFKCVR 266
Cdd:cd18477  76 REAKENRQKALPTVFESIR 94
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 168-267 6.03e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 56.70  E-value: 6.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRmgsirEETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18517   1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISK-----EEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWV 75

                        90       100
                ....*....|....*....|
gi 21359972 248 EAAAKERGPSAAEVFKCVRW 267
Cdd:cd18517  76 RTDKENRVKSLGEIFDCIRF 95
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 79-169 8.77e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 56.92  E-value: 8.77e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  79 GRLFSCNRNVLAAACPYFKSMFTGGMYESQQAS-----VTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQL 153
Cdd:cd18296  26 GHRFPCHKAFFCGRSDYFKALLRDHFAESEENNgsipvVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDVLYVADMYLL 105

                        90
                ....*....|....*.
gi 21359972 154 EYVREACASFLARRLD 169
Cdd:cd18296 106 PGLKRLCGTVLAQSLD 121
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-162 9.17e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 56.76  E-value: 9.17e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  39 ELKDTAHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTggmyESQQASVTMHDVD 118
Cdd:cd18224   3 KLHSSDHPNNLLKELNKCRLSETMCDVTIVV--------GNRSFAAHKAVLACAAGYFQKLFL----STELDVARTYVVD 70

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 21359972 119 ---AESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACAS 162
Cdd:cd18224  71 fitPANFEKVLSFIYTSELFTDLINVGVIYEVAEKLGMEDLLKACHS 117
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-172 9.69e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 57.21  E-value: 9.69e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIeVVTPGSGPGtgrlfscNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18266   8 HSNLVLQGLNEQRQRGLFCDVVL-VADEQRVPA-------HRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKA 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTN 172
Cdd:cd18266  80 VIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEEN 127
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 62-172 1.06e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 56.22  E-value: 1.06e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  62 LCDVTIEVVTpgsgpgtGRLFSCNRNVLAAACPYFKSMFTGGMYE-SQQASVTMhDVDAESFEVLVDYCYTGRVSLSEA- 139
Cdd:cd18302   5 LYDVTIVSED-------GKEFPCHKCVLVARLEYFHSMLSSSWIEaSSCSALTM-PIPSDILEIILDYLYTDEASAVKEs 76

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 21359972 140 -NVQRLY---AASDMLQLEYVREACASFLARRLDLTN 172
Cdd:cd18302  77 qNVEFLCnvlVIADQLLITRLKEICEVALVELLSLKN 113
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 168-266 1.07e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 56.11  E-value: 1.07e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMgsireETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18467   1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQT-----EEFFELTHAELDEIVSNDCLNVVTEETVFYALESWI 75

                        90
                ....*....|....*....
gi 21359972 248 EAAAKERGPSAAEVFKCVR 266
Cdd:cd18467  76 KYDVQERQKYLAQLLHCVR 94
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-164 1.31e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 56.59  E-value: 1.31e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  46 SAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMftggMYESQQASVTMHDVDAES-FEV 124
Cdd:cd18222   9 SNSVLSHLNQLRMQGRLCDIVVNV--------QGQSFRAHKVVLAASSPYFRDH----MSLNEMSTVSISVIKNPTvFEQ 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18222  77 LLSFCYTGRICLQLADIISYLTAASFLQMQHIIDKCTQIL 116
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 168-266 1.71e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 55.57  E-value: 1.71e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSrmgsiREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18460   1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELA-----KGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWV 75

                        90
                ....*....|....*....
gi 21359972 248 EAAAKERGPSAAEVFKCVR 266
Cdd:cd18460  76 KADPKHRQHFWPELLQHVR 94
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-164 1.86e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 55.63  E-value: 1.86e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18332   2 HSSDVLLNLNELRKRDILTDVTLLV--------GGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQL 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18332  74 LLDFMYTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFI 113
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 172-266 2.08e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 55.55  E-value: 2.08e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 172 NCTAILKFADAFDHHKLRSQAQSYIAHNFKQLsrmgsIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAA 251
Cdd:cd18446   5 NCVGILRLADAHSLESLKKQVQNYIIQNFSQV-----LNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKE 79

                        90
                ....*....|....*
gi 21359972 252 KERGPSAAEVFKCVR 266
Cdd:cd18446  80 SERLPLLPRVLENVR 94
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-164 3.84e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 55.03  E-value: 3.84e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMhdvDAESFEV 124
Cdd:cd18220   8 YSNTVLSQLNELRLQGKLCDIIVHI--------QGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIK---NPNVFEQ 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18220  77 LLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL 116
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-164 3.94e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 54.90  E-value: 3.94e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGmyESQQASVTMHDV-DAESFE 123
Cdd:cd18233   1 HSCHLLQQLHEQRIQGLLCDCMLVV--------KGVCFKAHKNVLAAFSQYFRSLFQNS--SSQKNDVFHLDIkNVGGIG 70

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21359972 124 VLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18233  71 QILDFMYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFL 111
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-164 4.50e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 54.95  E-value: 4.50e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  43 TAHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTmHDVDAESF 122
Cdd:cd18278  12 TVHCTNILLCLNDQRKQDILCDVTLIV--------EGKEFRAHRAVLAACSEYFLQALVGQTENDLVVSLP-EEVTARGF 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 21359972 123 EVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18278  83 GPLLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-172 5.44e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 55.05  E-value: 5.44e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  42 DTAHSAALLAQLKSFYDARLLCDVTIEvvtpgsgpGTGRLFSCNRNVLAAACPYFKSMFTGGmyesqqaSVTMHDVDAES 121
Cdd:cd18243  12 DPSHSDNLLHGLNLLWRKQLFCDVTLT--------AQGQQFHCHKAVLASCSQYFRSLFSIN-------NLVLQGCSSIG 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 21359972 122 FEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTN 172
Cdd:cd18243  77 LRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 62-172 5.68e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 54.41  E-value: 5.68e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  62 LCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANV 141
Cdd:cd18352  13 LSDVTFLV--------EGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIA 84

                        90       100       110
                ....*....|....*....|....*....|.
gi 21359972 142 QRLYAASDMLQLEYVREACASFLARRLDLTN 172
Cdd:cd18352  85 KDLLRAADQYLLEGLKRLCEYTIAQDLTLEN 115
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-166 5.91e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 54.66  E-value: 5.91e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  61 LLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGgmyeSQQASVTM-HDVDAESFEVLVDYCYTGRVSLSEA 139
Cdd:cd18290  26 LYCDVSVVV--------KGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELpAAVQPQSFQQILSFCYTGRLSMNVG 93

                        90       100
                ....*....|....*....|....*..
gi 21359972 140 NVQRLYAASDMLQLEYVREACASFLAR 166
Cdd:cd18290  94 DQFLLMYTAGFLQIQEIMEKGTEFFLK 120
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-163 6.55e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 54.17  E-value: 6.55e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTggmyesQQASVTMHDV-DAESFE 123
Cdd:cd18206   5 HSQHVLEQLNQQRQLGLLCDCTFVV--------DGVDFKAHKAVLAACSEYFRMLFV------DQKDVVHLDIsNAAGLG 70

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21359972 124 VLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASF 163
Cdd:cd18206  71 QVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-172 6.88e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 54.58  E-value: 6.88e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  40 LKDTAHSaaLLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDA 119
Cdd:cd18344   3 IKDPRHM--LTDDLGELWENSLFTDCCLLV--------AGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDP 72

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 21359972 120 ESFEVLVDYCYTGRVSL--SEANVQRLYAASDMLQLEYVREACASFLARRLDLTN 172
Cdd:cd18344  73 QVFKEMMGFIYTGKAPHlhSHSMACDVLAAADKYGLEGLKVLCEDALCRNLSVEN 127
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 168-266 7.35e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 53.85  E-value: 7.35e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRmgsiREETLAdLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18457   1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSK----SEEFLA-LSKEEVLEILSRDELNVKSEEQVFEAALAWV 75

                        90
                ....*....|....*....
gi 21359972 248 EAAAKERGPSAAEVFKCVR 266
Cdd:cd18457  76 KYDRENREEYLPELLSKVR 94
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-158 1.23e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 53.29  E-value: 1.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  43 TAHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESF 122
Cdd:cd18192   2 PSHSSYVLQQLNNQREWGFLCDCCIAI--------DDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKISAECF 73

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 21359972 123 EVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVRE 158
Cdd:cd18192  74 DLILQFMYLGKIMTAPSDFEQLKVAMNYLQLYYIPE 109
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-172 1.46e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 53.57  E-value: 1.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  79 GRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVRE 158
Cdd:cd18342  31 GQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKV 110

                        90
                ....*....|....
gi 21359972 159 ACASFLARRLDLTN 172
Cdd:cd18342 111 MCEDALCSNLSVEN 124
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 168-266 1.47e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 52.84  E-value: 1.47e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLsrmgsIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18516   1 LCLSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLI-----ARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWV 75

                        90
                ....*....|....*....
gi 21359972 248 EAAAKERGPSAAEVFKCVR 266
Cdd:cd18516  76 GKDQEERTKALPVLLESIR 94
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-165 1.82e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 52.91  E-value: 1.82e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpGSGPgtgrlFSCNRNVLAAACPYFKSMFTGGMYESQQASVtmhdVDAESFEV 124
Cdd:cd18225   6 YSRQLLQQLHTLRKEQQFCDCTIFI---GTFH-----FRAHKLVLAASSLLFKSLLDSTDTISIDASV----VSPEEFAL 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLA 165
Cdd:cd18225  74 LLEMVYTGKLPPGKHNFTKIISVADSLQMFDVAVSCKNLLT 114
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 172-266 2.44e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 51.98  E-value: 2.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 172 NCTAILKFADAFDHHKLRSQAQSYIAHNFKQLsrmgsIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAA 251
Cdd:cd18479   5 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAV-----YHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNT 79

                        90
                ....*....|....*
gi 21359972 252 KERGPSAAEVFKCVR 266
Cdd:cd18479  80 ESRSQYLSSVLSQIR 94
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-166 2.55e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 52.60  E-value: 2.55e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  44 AHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMftggmyesqqasvTMHD------- 116
Cdd:cd18333   3 SHSRQLLLQLNTQRTKGFLCDVIIVV--------QNALFRAHKNILAASSVYLKSL-------------VVHDnlinldh 61

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21359972 117 --VDAESFEVLVDYCYTGRVS----LSEANVQRLYAASDMLQLEYVREACASFLAR 166
Cdd:cd18333  62 emVSPGIFRLILDYIYTGRLSegdpGSEQNLGAVLAAASYLQIPDLVALCKKKLKR 117
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 168-254 2.73e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 51.56  E-value: 2.73e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRmgsiREETLaDLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18480   1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQ----SQEFL-ELNFEVLEKILEADELNVPDEEAVLKAVLRWT 75


                ....*..
gi 21359972 248 EAAAKER 254
Cdd:cd18480  76 KHDLEAR 82
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 168-256 3.62e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 51.14  E-value: 3.62e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRmgsirEETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18458   2 LDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQ-----SEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWV 76


                ....*....
gi 21359972 248 EAAAKERGP 256
Cdd:cd18458  77 KYDEENRRQ 85
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 62-167 8.42e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 51.08  E-value: 8.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  62 LCDVTIEVVTPGSgpgtgrLFSCNRNVLAAACPYFKSMFTGGMyESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANV 141
Cdd:cd18231  14 LCDVDIVLVRQRS------TFPAHKGVLAAYSQFFHSLFTQNK-QLQRVELSLEALTSQGLQQILNFIYTSKLLVNSCNV 86

                        90       100
                ....*....|....*....|....*.
gi 21359972 142 QRLYAASDMLQLEYVREACASFLARR 167
Cdd:cd18231  87 QDVLNAAAVLQMNDIAASCQELIDSR 112
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 79-141 1.00e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 49.82  E-value: 1.00e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21359972  79 GRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHD--VDAESFEVLVDYCYTGRVSLSEANV 141
Cdd:cd18190   8 GEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEEngISIEAMRAVIDFSVTGRLDLFSVEN 72
PHA02713 PHA02713
hypothetical protein; Provisional
 39-531 1.18e-07

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 55.02  E-value: 1.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972   39 ELKDTAHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQAS-VTMHDV 117
Cdd:PHA02713   2 DIDDIKHNRRVVSNISNLLDDDILCDVIITI-------GDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLVTrVNLQMF 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  118 DAESFEVLVDYCYTGRVslSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAIlkfadafdHHKLRSQAQSYIA 197
Cdd:PHA02713  75 DKDAVKNIVQYLYNRHI--SSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYM--------YHRLYEMSHIPIV 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  198 HNFKQLSrMGSIREETLADLTLAQLLAVLrldsLDIESERTVCHVAVQwleaaakergpsAAEVFKCVRWMHFTEEDQDY 277
Cdd:PHA02713 145 KYIKRML-MSNIPTLITTDAFKKTVFEIL----FDIISTNDNVYLYRE------------GYKVTILLKWLEYNYITEEQ 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  278 LEGLLTkpivkkyCLDVIEgaLQMRYGDLLYKSlvpvPNSSSSSSSSNSLVSAAENP---PQRLGMCAKEMVIFFGHPrd 354
Cdd:PHA02713 208 LLCILS-------CIDIQN--LDKKSRLLLYSN----KTINMYPSCIQFLLDNKQNRniiPRQLCLVCHDTKYNVCNP-- 272

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  355 pflCYDPYsgDIYTMPSPLTSFAHTKTVTSSAVCVspDHDIYLAA-----QPRKDLwVYK--PAQNSWQQLADRLLCREG 427
Cdd:PHA02713 273 ---CILVY--NINTMEYSVISTIPNHIINYASAIV--DNEIIIAGgynfnNPSLNK-VYKinIENKIHVELPPMIKNRCR 344

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  428 MDVAYLNGYIYILGGRDPiTGVKlKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAV------------------ 489
Cdd:PHA02713 345 FSLAVIDDTIYAIGGQNG-TNVE-RTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIggrtehidytsvhhmnsi 422

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 21359972  490 -------NSKRMLCYDPSHNMWLNCASLKRSDFQEACV-FNDEIYCICDI 531
Cdd:PHA02713 423 dmeedthSSNKVIRYDTVNNIWETLPNFWTGTIRPGVVsHKDDIYVVCDI 472
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-164 1.26e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 50.71  E-value: 1.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  46 SAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMftggMYESQQASVTMHDV-DAESFEV 124
Cdd:cd18227   9 SSTILQKLNQQRQQGQLCDISVVV--------QGHLFRAHKAVLAASSPYFCDQ----VLLKNSRRIVLPDVmNPRVFEN 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18227  77 ILLSCYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELL 116
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 62-167 1.58e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 50.43  E-value: 1.58e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  62 LCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTggMYESQQaSVTMHDVD-----AESFEVLVDYCYTGRVSL 136
Cdd:cd18196  21 LCDCVIVV--------GNRHFKAHRSVLAACSTHFRALFT--VAEGDQ-TMNMIQLDsevvtAEAFAALIDMMYTSTLML 89

                        90       100       110
                ....*....|....*....|....*....|.
gi 21359972 137 SEANVQRLYAASDMLQLEYVREACASFLARR 167
Cdd:cd18196  90 GESNVMDVLLAASHLHLNSVVKACKHYLTTR 120
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-154 1.63e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 50.18  E-value: 1.63e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  44 AHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQqaSVTMHD-VDAESF 122
Cdd:cd18212   5 THKDTVLTNFEEQRKKDFLCDITLIV--------ENVQFRAHKALLAASSEYFSMMFADEGEVGQ--SIYMLEgMVAETF 74

                        90       100       110
                ....*....|....*....|....*....|..
gi 21359972 123 EVLVDYCYTGRVSLSEANVQRLYAASDMLQLE 154
Cdd:cd18212  75 GALLEFIYTGCLQVGEKSLEQILATAQFLKVN 106
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-166 1.75e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 50.35  E-value: 1.75e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMftggmyesqqasvTMHD-------- 116
Cdd:cd18334   4 HAKQLLLQLNQQRAKGFLCDVIIVV--------ENALFRAHKNILAASSMYFKSL-------------VLHDnlinldtd 62

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 21359972 117 -VDAESFEVLVDYCYTGRV----SLSEANVQRLYAASDMLQLEYVREACASFLAR 166
Cdd:cd18334  63 mVNPTVFRQILDFIYTGKLltsdQPGEQNFNALLTAASYLQLHDLAALCRKKLKR 117
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 168-266 2.03e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 49.92  E-value: 2.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLsrmgsIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18445   1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEV-----VKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWV 75

                        90
                ....*....|....*....
gi 21359972 248 EAAAKERGPSAAEVFKCVR 266
Cdd:cd18445  76 NHDPENRKEHLAELLEHVR 94
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-158 2.50e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 50.03  E-value: 2.50e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  53 LKSFYDARLL---CDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGgmyESQQASVTMHDVDAESFEVLVDYC 129
Cdd:cd18289  17 LGCLNEQRLMglyCDVSIVV--------KGQAFKAHRAVLAASSLYFRDLFSG---NSKSAFELPATVPPACFQQILSFC 85

                        90       100
                ....*....|....*....|....*....
gi 21359972 130 YTGRVSLSEANVQRLYAASDMLQLEYVRE 158
Cdd:cd18289  86 YTGKLTMAASEQLVVMYTAGFLQIQHIVE 114
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-164 3.11e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 49.20  E-value: 3.11e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21359972  93 CPYFKSMFTGGMYESQQASVTM----HDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18305  37 SGYFASMFSGSWKESKETVINLeipdDNITVEALNVVFGSLYRDEIEIKPSRVVSILAAATLLQLDGLIQQCSEVM 112
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 172-269 4.06e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 48.47  E-value: 4.06e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 172 NCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMgsirEETLaDLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAA 251
Cdd:cd18455   4 NCIGIRDFAERFSCPHVHYVATEYLETHFRDVSST----EEFL-ELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDP 78

                        90
                ....*....|....*...
gi 21359972 252 KERGPSAAEVFKCVRWMH 269
Cdd:cd18455  79 EERKVHLKDLMSSCWRSG 96
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 45-151 4.72e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 48.36  E-value: 4.72e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAAcpyfKSMFTGGMYESQQASVTMH-DVDAESFE 123
Cdd:cd18262   1 HPSQFFGEAQRLREQRLLLDETVSV--------GGRSYGVHSVILAAV----SSLFRERLLGSNGPLPPLSlEVTPVGWE 68

                        90       100
                ....*....|....*....|....*...
gi 21359972 124 VLVDYCYTGRVSLSEANVQRLYAASDML 151
Cdd:cd18262  69 AVLTFAYTGVLGRNPATVGDILVAAEAL 96
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-166 5.31e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 48.68  E-value: 5.31e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMftggmyesqqasvTMHD-------- 116
Cdd:cd18216   3 HATQLLLQLNNQRTKGFLCDVIIVV--------ENSLFRAHKNVLAASSGYFKSL-------------VLHDnlihldqd 61

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 21359972 117 -VDAESFEVLVDYCYTGRVSLS---EANVQRLYAASDMLQLEYVREACASFLAR 166
Cdd:cd18216  62 mVSPTVFQQILDFIYTGKLLDSlfeEPNLSEVLAAANYLQLPDLAALCRSKLKR 115
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 168-266 6.37e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 48.19  E-value: 6.37e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSrmgsIREETLaDLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18485   1 MDASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVC----LHEEVL-EIEAHQLLTLIKSDDLNVSREESILDLVLRWV 75

                        90
                ....*....|....*....
gi 21359972 248 EAAAKERGPSAAEVFKCVR 266
Cdd:cd18485  76 NHNRKSRVQHLVELLKQVR 94
PHA02790 PHA02790
Kelch-like protein; Provisional
 85-246 8.15e-07

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 51.97  E-value: 8.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972   85 NRNVLAAACPYFKSMFTGgMYESQQASVTM--HDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACAS 162
Cdd:PHA02790  36 NSTILKKLSPYFRTHLRQ-KYTKNKDPVTRvcLDLDIHSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCIN 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  163 FLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLsrmgsiREETLADLTLAQLLAVLRLDSLDIESERTVCHV 242
Cdd:PHA02790 115 FILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLEL------EDDIIDNFDYLSMKLILESDELNVPDEDYVVDF 188


                 ....
gi 21359972  243 AVQW 246
Cdd:PHA02790 189 VIKW 192
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 62-164 1.29e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 47.08  E-value: 1.29e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  62 LCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTmHDVDAESFEVLVDYCYTGRVSLSEANV 141
Cdd:cd18955   1 LCDVTIVV--------EDQRFRAHRAVLAACSDYFLSRVVGQTDGDLVITLP-EEVTVKGFEPLLQFAYTAKLLLSKENV 71

                        90       100
                ....*....|....*....|...
gi 21359972 142 QRLYAASDMLQLEYVREACASFL 164
Cdd:cd18955  72 LEVCRCAEFLGVHNIEKACFDFL 94
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-163 1.43e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 47.28  E-value: 1.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  46 SAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMY-ESQQASVTMHDVD--AESF 122
Cdd:cd18292   1 SREFLQDIAQLYNNEELSDIVLRV--------GGKVFHAHRLILAKSSDVFRVMLSNDWWsESKQSEIELVEDPecAAVF 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21359972 123 EVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASF 163
Cdd:cd18292  73 EKFLRYLYTGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-166 1.45e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 47.57  E-value: 1.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEvvtpgsgpGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVtMHdvdaeSFEV 124
Cdd:cd18203   8 HEAATLRNMNQLRSEERFCDVTIV--------ADSLKFRGHKVVLAACSPFLRDQFLLNPSSELQVSL-MH-----SSRV 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 21359972 125 LVDY---CYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLAR 166
Cdd:cd18203  74 VADLllsCYTGALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQ 118
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 169-248 1.50e-06

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 46.25  E-value: 1.50e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 169 DLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLsrmgsIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLE 248
Cdd:cd18508   1 DATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEV-----IQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLK 75
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-166 1.68e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 47.37  E-value: 1.68e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  46 SAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVtmhdVDAESFEVL 125
Cdd:cd18208   9 SNSVLETLNEQRNRGHFCDVTVRI--------HGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSV----VSVQSVQKL 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21359972 126 VDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLAR 166
Cdd:cd18208  77 IDFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQ 117
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-172 1.91e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 47.75  E-value: 1.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  44 AHSAALLAQLKSFYDARLLCDVTIEV---VTPGSGPGTGRLfSCNRNVLAAACPYFKSMFTGGMyESQQASVTMHDVDAE 120
Cdd:cd18346   4 ATKSSLKERFAFLFNNELLSDVRFVVgkgRPRGPGPGAQRI-PAHRFVLAAGSAVFDAMFNGGM-ATTSAEIELPDVEPA 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 21359972 121 SFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTN 172
Cdd:cd18346  82 AFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 168-246 2.59e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 45.68  E-value: 2.59e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFkqlSRMGSIREETLaDLTLAQLLAVLRLDSLDIESERTVCHVAVQW 246
Cdd:cd18450   1 LTPENCIGIRKFARYYFCPELERKAYRYILRNF---EEVAKDSEEFL-ELSCEELEDIIEDDELNVKEEEVVFEAIVKW 75
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 167-248 2.97e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 45.46  E-value: 2.97e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 167 RLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLsrmgSIREETLaDLTLAQLLAVLRLDSLDIESERTVCHVAVQW 246
Cdd:cd18463   1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEV----SQHEEFL-ELCKDELIEYISNDELVVPKEEEVFEAVMRW 75


                ..
gi 21359972 247 LE 248
Cdd:cd18463  76 VY 77
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 169-227 3.14e-06

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 44.57  E-value: 3.14e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21359972 169 DLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSrmgsiREETLADLTLAQLLAVLR 227
Cdd:cd14733   1 DPENCLGILELADLYNLEELKEKALKFILENFEEVS-----KSEEFLELSVELLLELLS 54
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-168 3.25e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 46.51  E-value: 3.25e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  55 SFYDARLLCDVTIeVVTPgsgPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQqASVTMHDVDAESFEVLVDYCYTGRV 134
Cdd:cd18349   1 LMFNNELMADVHF-IVGP---PGASQRVPAHKYVLAVGSSVFYAMFYGDLAEVK-SEIHIPDVEPAAFLILLKYMYSDEI 75

                        90       100       110
                ....*....|....*....|....*....|....*
gi 21359972 135 SLSEANV-QRLYAASDMLqLEYVREACASFLARRL 168
Cdd:cd18349  76 DLEADTVlATLYAAKKYI-VPALAKACVNFLETSL 109
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-162 3.62e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 46.38  E-value: 3.62e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFT-GGMYESQQASVTMHDVDAESFE 123
Cdd:cd18202   2 HGQTVLDQLNQQRLNNQFCDVTLLI--------EGEEYKAHKSVLAANSEYFRELFIeKGAVSSHEAVVDLSGFCKSSFL 73

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 21359972 124 VLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACAS 162
Cdd:cd18202  74 PLLEFAYTSELTFDFCSMAEVAMLARHLFMNEVLEICES 112
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 62-164 3.69e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 46.37  E-value: 3.69e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  62 LCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYF-KSMFTGGMyesqqASVTMHDV-DAESFEVLVDYCYTGRVSLSEA 139
Cdd:cd18210  21 LCDISIHV--------QGRVFRAHRAVLAASSPYFhDQVLLKNM-----SSISLPGVmDPGAFESVLASAYTGKLTMLAD 87

                        90       100
                ....*....|....*....|....*
gi 21359972 140 NVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18210  88 EIVNYLTVGSVLQMWHIVDKCTELL 112
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-168 3.90e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 46.23  E-value: 3.90e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  61 LLCDVTIEVvtpGSGPGTGRLFScNRNVLAAACPYFKSMFTGGMYEsQQASVTMHDVDAESFEVLVDYCYTGRVSLSEAN 140
Cdd:cd18282   6 LMADVHFIV---GPPGGTQRIPA-HKYVLATGSSVFYAMFYGGLAE-NKNEIEIPDVEPAAFLNLLRYLYCDEIDLEPDT 80

                        90       100
                ....*....|....*....|....*....
gi 21359972 141 V-QRLYAASDMLqLEYVREACASFLARRL 168
Cdd:cd18282  81 VlATLYAAKKYL-VPHLARACVQFLETSL 108
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 168-267 3.94e-06

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 45.93  E-value: 3.94e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSrmgsIREETLAdLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18466   1 IDPANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQ----SGEEFLG-LTKDQLVKILRSEELSIEDEYQVFTAAMEWI 75

                        90       100
                ....*....|....*....|
gi 21359972 248 EAAAKERGPSAAEVFKCVRW 267
Cdd:cd18466  76 LKDVGKRKKHVVEVLEPVRF 95
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-167 4.56e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 46.36  E-value: 4.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpGTGRlFSCNRNVLAAACPYFKsMFtggmYESQ---QASVTMHD--VDA 119
Cdd:cd18323   6 HSRHLLQSLREQRHQGFLCDCTVLV-------GSTQ-FLAHRAVLASCSPFFH-MF----YKEQldkRDLVCINNeiVTA 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 21359972 120 ESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARR 167
Cdd:cd18323  73 PAFSLLLEFMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVCKKRLQAR 120
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 64-164 4.79e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 45.67  E-value: 4.79e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  64 DVTIevVTPGsgpgtGRLFSCNRNVLAAACPYFKSMFtggmyeSQQASVTMH-DVDAESFEVLVDYCYTGRVSLSEANVQ 142
Cdd:cd18299  14 DVVF--ILQG-----GVRIFAHRIVLAAASSVFADLF------LMMTVVTLDsDITPEAFRRVLEFLYTGVLDENEDDLK 80

                        90       100
                ....*....|....*....|..
gi 21359972 143 RLYAASDMLQLEYVREACASFL 164
Cdd:cd18299  81 ELKDAAELLELFDLVMMCTNVL 102
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-160 5.07e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 46.50  E-value: 5.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQL-KSFYDARLLCDVTIEVVTPGsgpgtgrlFSCNRNVLAAACPYFKSMFTGGMYESQQA-SVTMHDVDAESF 122
Cdd:cd18207   9 HSADMLHNLnQQRKSGGRFCDVLLRVGEES--------FPAHRAVLAACSEYFESVFSAQEGDGGTPrELEMHTISSKVF 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 21359972 123 EVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREAC 160
Cdd:cd18207  81 GDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDIC 118
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 167-267 5.33e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 45.43  E-value: 5.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 167 RLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMgsireETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQW 246
Cdd:cd18447   1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKT-----DEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW 75

                        90       100
                ....*....|....*....|.
gi 21359972 247 LEAAAKERGPSAAEVFKCVRW 267
Cdd:cd18447  76 LKYDEPNRQPYMVDILAKVRF 96
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-164 5.43e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 45.61  E-value: 5.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFtggMYESQQASVTMHDVDAESFEV 124
Cdd:cd18200   1 YSSALLETLNKHRLEGKFCDLSVHV--------QGRVFRAHKAVLAASSPYFHDKL---LLNDTNCLVLPSVIEAAAFEN 69

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21359972 125 LVDYCYTGRVSLS-EANVQRLYAASDmLQLEYVREACASFL 164
Cdd:cd18200  70 LLQLIYSGRLTLCmDALPSHLLVASG-LQMWQVVDRCSELL 109
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 168-266 5.50e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 45.38  E-value: 5.50e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMgsireETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18456   1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKT-----EEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWV 75

                        90
                ....*....|....*....
gi 21359972 248 EAAAKERGPSAAEVFKCVR 266
Cdd:cd18456  76 KHDVDGRRQHVPRLMKCVR 94
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-172 5.96e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 45.89  E-value: 5.96e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  57 YDARLLCDVTIEVvtpGSGPGTGRLfSCNRNVLAAACPYFKSMFTGGMyESQQASVTMHDVDAESFEVLVDYCYTGRVSL 136
Cdd:cd18281  17 FNNETLSDVHFIV---GKGDNEQRI-PAHKFVLSIGSAVFDAMFNGGM-ATTSAEIELPDVEPAAFLALLRFLYSDEVQI 91

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 21359972 137 SEANVQ-RLYAASDMlQLEYVREACASFLARRLDLTN 172
Cdd:cd18281  92 GPETVMtTLYTAKKY-AVPALESACVEFLKKNLSSDN 127
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-151 7.50e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 45.65  E-value: 7.50e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpGTGRlFSCNRNVLAAACPYFKSMFT-------------GGMYESQQAS 111
Cdd:cd18195   1 HAGALLLQLNEQRLRGLFCDVTLIA-------GDTK-FRAHRSVLAASSPYFRELLSsplplgaaavaaaPGATQSPERV 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21359972 112 VTMHDVDAESFEVLVDYCYTGRVSL-SEANVQRLYAASDML 151
Cdd:cd18195  73 LELPGVKAGVFSDVLNFIYSSRVALpGSAAAKELGAAGKRL 113
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 167-266 1.21e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 44.34  E-value: 1.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 167 RLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLsrmgsIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQW 246
Cdd:cd18459   1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEV-----MESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAW 75

                        90       100
                ....*....|....*....|
gi 21359972 247 LEAAAKERGPSAAEVFKCVR 266
Cdd:cd18459  76 VKYNIQERRPHLPQVLQHVR 95
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 49-152 1.45e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 44.50  E-value: 1.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  49 LLAQLKSFYDARLLCDVTIEVVTpgsgpgtGRLFSCNRNVLAAACPYFKSMftGGMYESQQASVTM-HDVDAESFEVLVD 127
Cdd:cd18311   1 FLQRLQNLFNKTEYCDLTLQFRD-------NEQLKVHRLVLSACTDYFNVL--EQTCEIVDDTLIMpNELQADAVVPVIN 71

                        90       100
                ....*....|....*....|....*
gi 21359972 128 YCYTGRVSLSEANVQRLYAASDMLQ 152
Cdd:cd18311  72 FMYTGQLEFEEKSYGKLLRTAKELN 96
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 168-247 1.45e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 43.53  E-value: 1.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSireetLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18472   1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAA-----FLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-138 1.95e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 44.39  E-value: 1.95e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEV 124
Cdd:cd18223   1 HSDTVLSCLNEQRIQGILCDVTIVV--------EDTKFKAHKNVLAASSLYFKNAFSSQEIWISSHVLELPDLKAEVFAE 72

                        90
                ....*....|....
gi 21359972 125 LVDYCYTGRVSLSE 138
Cdd:cd18223  73 ILNFIYSSKVVVKR 86
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 171-266 2.53e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 44.29  E-value: 2.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 171 TNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLsrmgSIREETLAdLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAA 250
Cdd:cd18513   4 TNCLGIRAFADVHTCTELLQQANAYAEQHFPEV----MLGEEFLS-LSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYD 78

                        90
                ....*....|....*.
gi 21359972 251 AKERGPSAAEVFKCVR 266
Cdd:cd18513  79 KEARLEHMAKLMEHVR 94
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-160 3.43e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 44.04  E-value: 3.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpGSGPgtgrlFSCNRNVLAAACPYFKsMFtggmYESQQAS---VTMHD--VDA 119
Cdd:cd18194   6 HSRQLLQCLREQRSQGFLCDCTVLV---GSAQ-----FPAHRAVLASCSMYFH-LF----YRDRLDKrdlVRLNSdiVTA 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21359972 120 ESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREAC 160
Cdd:cd18194  73 PAFGLLLDFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVC 113
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 64-177 3.68e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 43.24  E-value: 3.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  64 DVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTmhdvdaeSFEVLVDYCYTGRVSLSEANVQR 143
Cdd:cd18275   6 DLVIEV--------SGQRIRAHKSVLAAKSDYFRARLSRDILKVKGLSYA-------TLRLLVDYVYSGRMAVSKDNVVE 70

                        90       100       110
                ....*....|....*....|....*....|....
gi 21359972 144 LYAASDMLQLEYVREACASFLARRLDLTNCTAIL 177
Cdd:cd18275  71 VVAGARFLQMPCAAQCAVDAVRAQLCLGNCYEVL 104
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-164 3.73e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 42.94  E-value: 3.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  80 RLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMlqLEYVREA 159
Cdd:cd18319  11 RCYNVSKRKLIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVHESQGDSTDTLEENEL--LEDLVEA 88


                ....*
gi 21359972 160 cASFL 164
Cdd:cd18319  89 -ASFL 92
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 79-151 4.08e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 42.71  E-value: 4.08e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21359972  79 GRLFSCNRNVLAAACPYFKSMFTGgmYESQQASVTMH----DVDAESFEVLVDYCYTGRVSLSEANVQRLyaasDML 151
Cdd:cd18283  11 GTCFPVHRAILSARCPFFRDLLSS--SPGYGAEIPVDlptaGIDVPMFSALLRYLYTGEFGSEDSRSQNL----DVL 81
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 168-267 4.35e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 42.94  E-value: 4.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMgsireETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18470   1 INVENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSET-----DQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWL 75

                        90       100
                ....*....|....*....|
gi 21359972 248 EAAAKeRGPSAAEVFKCVRW 267
Cdd:cd18470  76 DFDQK-RVKYAADLLSNIRF 94
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-167 4.96e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 42.92  E-value: 4.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  46 SAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVtmhdVDAESFEVL 125
Cdd:cd18229   2 SKSLLETLNAQRLGGHFCDVTVRI--------HDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPV----VPAQTVRQL 69

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 21359972 126 VDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARR 167
Cdd:cd18229  70 VEFMYSGSLVVAQSEALQILTAASILQIKTVIDECTQIISQS 111
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 425-471 6.04e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 40.67  E-value: 6.04e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 21359972   425 REGMDVAYLNGYIYILGGRDPITGvkLKEVECYSVQRNQWALVAPVP 471
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQS--LNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-153 6.40e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 42.85  E-value: 6.40e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  49 LLAQLKSFYDARLLCDVTIEvvtpgsgpGTGRLFSCNRNVLAAACPYFKSMFTGGMY-ESQQASVTMHDVDAESFEVLVD 127
Cdd:cd18293   2 AFLQLHRQQNSGVFCDVLLQ--------AEGESVPAHCCVLSACSPYLTERLSSEPPpAGQKVVLELQGLKAHTLLKLVD 73

                        90       100
                ....*....|....*....|....*.
gi 21359972 128 YCYTGRVSLSEANVQRLYAASDMLQL 153
Cdd:cd18293  74 FLYTSELEVSSEEAQDVLAAARRLQI 99
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 168-249 8.12e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 41.34  E-value: 8.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREetladLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18474   1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLK-----LELQLVLELLADDSLAVRSEEVVLEAALRWV 75


                ..
gi 21359972 248 EA 249
Cdd:cd18474  76 DA 77
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-172 1.10e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 42.37  E-value: 1.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  56 FYDARLLCDVTIEVvtpGSGPGTGRLfSCNRNVLAAACPYFKSMFTGGMyESQQASVTMHDVDAESFEVLVDYCYTGRVS 135
Cdd:cd18347  16 LFNNEVLSDVHFLV---GKGLGSQRI-PAHRFVLAVGSAVFDAMFNGGM-ATTSTEIELPDVEPAAFLALLKFLYSDEVQ 90

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 21359972 136 LSEANVQRLYAASDMLQLEYVREACASFLARRLDLTN 172
Cdd:cd18347  91 IGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 168-266 1.40e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 42.39  E-value: 1.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLsrmgsIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18452   1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEV-----VQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWV 75

                        90
                ....*....|....*....
gi 21359972 248 EAAAKERGPSAAEVFKCVR 266
Cdd:cd18452  76 KHDKEEREDYLPELLQYVR 94
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 79-134 1.48e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 41.85  E-value: 1.48e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21359972  79 GRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRV 134
Cdd:cd18295  28 GESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTGRL 83
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-144 1.50e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 41.78  E-value: 1.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKsfyDARL---LCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQqaSVTMHDV-DAE 120
Cdd:cd18209   1 HAISLLSALN---EERLkgqLCDVLLIV--------GDQKFRAHKNVLAASSEYFQSLFTEKENESQ--SVFQLDFcEPD 67

                        90       100
                ....*....|....*....|....*..
gi 21359972 121 SFEVLVDYCYTGRVSL---SEANVQRL 144
Cdd:cd18209  68 AFENVLNYIYSSSLFVeksSLAAVQEL 94
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-161 1.51e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 41.56  E-value: 1.51e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  53 LKSFYDARL---LCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTggMYESQQASVTMHD-VDAESFEVLVDY 128
Cdd:cd18204   6 LKTLNEQRLegeFCDIAIVV--------EDVKFRAHRCVLAACSTYFKKLFK--KLEVDSSSVIEIDfLRSDIFEEVLNY 75

                        90       100       110
                ....*....|....*....|....*....|...
gi 21359972 129 CYTGRVSLSEANVQRLYAASDMLQLEYVREACA 161
Cdd:cd18204  76 MYTAKISVKKEDVNLMMSSGQILGIRFLDKLCS 108
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-177 1.94e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 41.93  E-value: 1.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  57 YDARLLCDVTIEVVTPGsgpGTGRLfSCNRNVLAAACPYFKSMFTGGMYESQQaSVTMHDVDAESFEVLVDYCYTGRVSL 136
Cdd:cd18348  16 FNNDLMADIHFVVGPPG---GTQRL-PGHKYVLAVGSSVFHAMFYGELAEDKD-EIRIPDVEPAAFLAMLKYIYCDEIDL 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 21359972 137 SEANV-QRLYAASDMLqLEYVREACASFLARRLDLTNCTAIL 177
Cdd:cd18348  91 AADTVlATLYAAKKYI-VPHLARACVNFLETSLSAKNACVLL 131
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 53-168 1.97e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 41.37  E-value: 1.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  53 LKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTG 132
Cdd:cd18360   1 LGLFFNSPLLADVVFKI--------QGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTD 72

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 21359972 133 R-VSLSEANVQRLYAASDMLQLEYVREACASFLARRL 168
Cdd:cd18360  73 ScCPASILQAMALLICAEMYQVSRLQHICELYIITQL 109
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 63-149 2.10e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 41.60  E-value: 2.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  63 CDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDV--DAESFEVLVDYCYTGRVSLSEAN 140
Cdd:cd18309  21 CDITLLL--------DGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMvpSRQAFDSLLRYIYYGDVTMPPED 92


                ....*....
gi 21359972 141 VQRLYAASD 149
Cdd:cd18309  93 SLYLFSAPY 101
BTB_POZ_ARMC5 cd18191
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 77-164 2.12e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349500 [Multi-domain]  Cd Length: 100  Bit Score: 40.95  E-value: 2.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  77 GTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCY--TGRVSLSEANVQRLYAASDMLQ-- 152
Cdd:cd18191   9 DGGTQLPASRAALTGASEVFRAMLEGGFAEAQQDLVPLRQVPSGAFLPVLHYLHgcRGCDANEDDEKSDQSPEGDLMKss 88

                        90
                ....*....|..
gi 21359972 153 LEYVREACASFL 164
Cdd:cd18191  89 LGQTLEVAGRFL 100
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 167-266 2.34e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 40.82  E-value: 2.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 167 RLDLTNCTAILKFADA---FDHHKlrsqaqsyIAHNFKQLSRMGSIREETLADLTLAQLLAVLRLDSLDIESERTVCHVA 243
Cdd:cd18511   1 QLHPSNCLGIRSFADAqgcTDLHK--------VAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNAL 72

                        90       100
                ....*....|....*....|...
gi 21359972 244 VQWLEAAAKERGPSAAEVFKCVR 266
Cdd:cd18511  73 LSWVRHDVEQRRKDLSKLLAYIR 95
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 54-153 2.51e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 40.78  E-value: 2.51e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  54 KSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGgMYESQQASVTMHDV--DAESFEVLVDYCYT 131
Cdd:cd18312   1 SWFRDTGEPSDITVRV--------GNTTFHLHKFPLCSKSGYFKRLASS-SSESDPSEIELNDFpgGAEAFELVAKFCYG 71

                        90       100
                ....*....|....*....|..
gi 21359972 132 GRVSLSEANVQRLYAASDMLQL 153
Cdd:cd18312  72 MPINLTATNVVGLRCAAEYLEM 93
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 171-254 3.39e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 40.39  E-value: 3.39e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 171 TNCTAILKFADAFDHHKLRSQAQSYIAHNFkqlsrMGSIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAA 250
Cdd:cd18509   5 SNCLGIRAFADAQGCIELMKVAHSYTMENI-----MEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYD 79


                ....
gi 21359972 251 AKER 254
Cdd:cd18509  80 MQRR 83
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-173 4.29e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 40.99  E-value: 4.29e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  56 FYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMH--DVDAESFEVLVDYCYTG- 132
Cdd:cd18350  18 FLNNKEMSDVTFLV--------EGKLFYAHKVLLVTASNRFKSLLTNKSEQESQGSKTIEisDIKYHIFQMLMQYLYYGg 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 21359972 133 --RVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18350  90 teSMEIPIADVLELLSAASLFQLDALQRHCEILCSQTINLENA 132
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-164 4.87e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 40.02  E-value: 4.87e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFtggmyESQQASVTMHDVDAESFEV 124
Cdd:cd18205   1 HPTGLLHKANQMRLAGTLCDVVIMV--------DSQEFHAHRTVLACTSKMFEILF-----HRNSQHYTLDFLSPKTFQQ 67

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21359972 125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
Cdd:cd18205  68 ILEYAYTATLQAKVEDLDDLLYAAEILEIEYLEEQCLKIL 107
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 171-266 5.78e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 39.60  E-value: 5.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 171 TNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLsrmgsIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAA 250
Cdd:cd18448   5 SNCLGVRTFAEQHNRVDLMKMADKYACDHFNEV-----VECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHD 79

                        90
                ....*....|....*.
gi 21359972 251 AKERGPSAAEVFKCVR 266
Cdd:cd18448  80 PQHRKRHLDDLLSQVR 95
Kelch_6 pfam13964
Kelch motif;
424-472 6.54e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.09  E-value: 6.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 21359972   424 CREGMDVAYLNGYIYILGGRDPITGVKLKeVECYSVQRNQWALVAPVPH 472
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNK-LEVYNPLTKSWEELPPLPT 48
Kelch_3 pfam13415
Galactose oxidase, central domain;
434-471 7.27e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 37.65  E-value: 7.27e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 21359972   434 NGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVP 471
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQIGDLP 38
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 171-266 7.37e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 40.01  E-value: 7.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 171 TNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLsrmgsIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAA 250
Cdd:cd18512   4 TNCLGIRAFADMHACTELLNQANTYAEQHFSDV-----VLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHD 78

                        90
                ....*....|....*.
gi 21359972 251 AKERGPSAAEVFKCVR 266
Cdd:cd18512  79 KEVRQEHMAHLMEHVR 94
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-158 1.01e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 39.04  E-value: 1.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  42 DTAHSAALLAQLKSFYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTggmyeSQQASVTMHDVDAES 121
Cdd:cd18219   1 DTQYSGSLLKSLNEQRGHGLFCDVTVIV--------EDRKFRAHKNILSASSTYFHQLFS-----VAGQVVELNFIRADI 67

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 21359972 122 FEVLVDYCYTGR-VSLSEANVQRLYAASDMLQLEYVRE 158
Cdd:cd18219  68 FAEILNYIYSSKiVRVRSDLLEELIKSGQLLGVKFIAE 105
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 168-266 1.71e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 38.18  E-value: 1.71e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRmgsirEETLADLTLAQLLAVLRLDSLdIESERTVCHVAVQWL 247
Cdd:cd18476   1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAA-----SEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWI 74

                        90
                ....*....|....*....
gi 21359972 248 EAAAKERGPSAAEVFKCVR 266
Cdd:cd18476  75 RHDPKARKGYIHDLFKKVR 93
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 168-239 1.74e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 38.59  E-value: 1.74e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREetladLTLAQLLAVLRLDSLDIESERTV 239
Cdd:cd18461   1 VDEENILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQ-----LPLEKVYSLLSSNRLEVDSENEV 67
Kelch_4 pfam13418
Galactose oxidase, central domain;
434-472 2.14e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.44  E-value: 2.14e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21359972   434 NGYIYILGGRDPItGVKLKEVECYSVQRNQWALVAPVPH 472
Cdd:pfam13418  12 DDTIYLFGGEGED-GTLLSDLWVFDLSTNEWTRLGSLPS 49
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 167-254 2.16e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 38.08  E-value: 2.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 167 RLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFkqlsrMGSIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQW 246
Cdd:cd18444   1 QLHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHF-----MEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLW 75


                ....*...
gi 21359972 247 LEAAAKER 254
Cdd:cd18444  76 VKHDLPER 83
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 177-247 2.85e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 36.79  E-value: 2.85e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21359972 177 LKFADAFDHHKLRSQAQSYIAHNFKQLSRMgsirEETLAdLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18493   9 LQYAKMCGHKELAEACLEFIAWNFEKVLKS----PDWLN-LDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 168-247 3.11e-03

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 37.60  E-value: 3.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSrmgsiREETLADLTLAQLLAVLR-LDSLDIESERTVCHVAVQW 246
Cdd:cd18502   1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVA-----ESKEFLKLPRLQIEVILEsNQELESINERKLCQLVLEW 75


                .
gi 21359972 247 L 247
Cdd:cd18502  76 V 76
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-173 4.72e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 37.65  E-value: 4.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  56 FYDARLLCDVTIEVvtpgsgpgTGRLFSCNRNVLAAACPYFKSMFTGGMyESQQASVTMHDVDAESFEVLVDYCYTG--- 132
Cdd:cd18351  18 FLNNKEMSDVTFLV--------EGRPFYAHKVLLFTASPRFKALLSNKP-SAENTCIEISYVKYHIFQLVMQYLYCGgte 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21359972 133 RVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNC 173
Cdd:cd18351  89 SLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTENC 129
BTB_POZ_KBTBD13 cd18320
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-125 4.72e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349629 [Multi-domain]  Cd Length: 83  Bit Score: 36.63  E-value: 4.72e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 21359972  79 GRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVL 125
Cdd:cd18320  10 EQLFTVDKALLVENSEYFRALFRSGMRECTQDEIRLQGLSARGFRIM 56
Kelch smart00612
Kelch domain;
437-472 5.50e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.23  E-value: 5.50e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 21359972    437 IYILGGRDPitGVKLKEVECYSVQRNQWALVAPVPH 472
Cdd:smart00612   2 IYVVGGFDG--GQRLKSVEVYDPETNKWTPLPSMPT 35
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-166 6.16e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 37.11  E-value: 6.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  45 HSAALLAQLKSFYDARLLCDVTI---EVVTPGsgpgtgrlfscNRNVLAAACPYFKSMFTggMYESQQASVTMHDvDAES 121
Cdd:cd18214   8 YGDSMLQKMNKLREQNKFCDVTVhidDLEVPG-----------HKVVFAAGSPFLRDQFL--LNDSREVQISILQ-NSEV 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 21359972 122 FEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLAR 166
Cdd:cd18214  74 GRQLLLSCYTGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWK 118
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 64-138 6.50e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 37.67  E-value: 6.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972  64 DVTIEVvtpgsgpGTGRLFSCNRNVLAAACPYFKSMFT--GGMYESQQASVTMHD------VDAESFEVLVDYCYTGRVS 135
Cdd:cd18310  20 DAEIIV-------EGGRPVPVHRCILAARSPFFRDIFAsaKAEGANTKPKLELRElipggiVGYDAFMLVLSYLYSGRLR 92


                ...
gi 21359972 136 LSE 138
Cdd:cd18310  93 LVP 95
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 166-273 7.80e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 36.66  E-value: 7.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 166 RRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSrmgsiREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQ 245
Cdd:cd18469   1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVS-----QEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLR 75

                        90       100
                ....*....|....*....|....*...
gi 21359972 246 WLEAAAKERGPSAAEVFKCVRWMHFTEE 273
Cdd:cd18469  76 WVGHDPQARAAHLPELLSLVHLSLLTDQ 103
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 168-249 8.72e-03

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 35.79  E-value: 8.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21359972 168 LDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRmgsIREetLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWL 247
Cdd:cd18503   1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSG---TRE--FLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWT 75


                ..
gi 21359972 248 EA 249
Cdd:cd18503  76 EH 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH