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Conserved domains on  [gi|116063536|ref|NP_115690|]
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2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial precursor [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10011316)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:0032259|GO:1904047
PubMed:  9045837|12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 56-327 9.41e-126

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


:

Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 359.47  E-value: 9.41e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  56 FETVSEEEKGGKVYQVFESVAKKYDVMNDMMSLGIHRVWKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFLNYVQSQhqrk 135
Cdd:PRK00216   1 FMTVAEEEKQEKVAEMFDSIAPKYDLMNDLLSFGLHRVWRRKTIKWLGVRPGDKVLDLACGTGDLAIALAKAVGKT---- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 136 qkrqlraqqnlsweeiakeyqneedslggSRVVVCDINKEMLKVGKQKALAQGYRAGLAWVLGDAEELPFDDDKFDIYTI 215
Cdd:PRK00216  77 -----------------------------GEVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGDAEALPFPDNSFDAVTI 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 216 AFGIRNVTHIDQALQEAHRVLKPGGRFLCLEFSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQE 295
Cdd:PRK00216 128 AFGLRNVPDIDKALREMYRVLKPGGRLVILEFSKPTNPPLKKAYDFYLFKVLPLIGKLISKNAEAYSYLAESIRAFPDQE 207

                        250       260       270
                 ....*....|....*....|....*....|..
gi 116063536 296 EFKDMIEDAGFHKVTYESLTSGIVAIHSGFKL 327
Cdd:PRK00216 208 ELAAMLEEAGFERVRYRNLTGGIVALHVGYKP 239
 
Name Accession Description Interval E-value
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 56-327 9.41e-126

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 359.47  E-value: 9.41e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  56 FETVSEEEKGGKVYQVFESVAKKYDVMNDMMSLGIHRVWKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFLNYVQSQhqrk 135
Cdd:PRK00216   1 FMTVAEEEKQEKVAEMFDSIAPKYDLMNDLLSFGLHRVWRRKTIKWLGVRPGDKVLDLACGTGDLAIALAKAVGKT---- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 136 qkrqlraqqnlsweeiakeyqneedslggSRVVVCDINKEMLKVGKQKALAQGYRAGLAWVLGDAEELPFDDDKFDIYTI 215
Cdd:PRK00216  77 -----------------------------GEVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGDAEALPFPDNSFDAVTI 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 216 AFGIRNVTHIDQALQEAHRVLKPGGRFLCLEFSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQE 295
Cdd:PRK00216 128 AFGLRNVPDIDKALREMYRVLKPGGRLVILEFSKPTNPPLKKAYDFYLFKVLPLIGKLISKNAEAYSYLAESIRAFPDQE 207

                        250       260       270
                 ....*....|....*....|....*....|..
gi 116063536 296 EFKDMIEDAGFHKVTYESLTSGIVAIHSGFKL 327
Cdd:PRK00216 208 ELAAMLEEAGFERVRYRNLTGGIVALHVGYKP 239
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
67-326 5.30e-101

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 296.27  E-value: 5.30e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536   67 KVYQVFESVAKKYDVMNDMMSLGIHRVWKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFLNYVQSQhqrkqkrqlraqqnl 146
Cdd:pfam01209   3 RVGDVFSSVASKYDLMNDVISFGIHRLWKDFTMKCMGVKRGNKFLDVAGGTGDWTFGLSDSAGSS--------------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  147 sweeiakeyqneedslggSRVVVCDINKEMLKVGKQKALAQGYRaGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHID 226
Cdd:pfam01209  68 ------------------GKVVGLDINENMLKEGEKKAKEEGKY-NIEFLQGNAEELPFEDDSFDIVTISFGLRNFPDYL 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  227 QALQEAHRVLKPGGRFLCLEFSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDAGF 306
Cdd:pfam01209 129 KVLKEAFRVLKPGGRVVCLEFSKPENPLLSQAYELYFKYVMPFMGKMFAKSYKSYQYLQESIRDFPDQKTLASMFEKAGF 208

                         250       260
                  ....*....|....*....|
gi 116063536  307 HKVTYESLTSGIVAIHSGFK 326
Cdd:pfam01209 209 KSVGYESLTGGIAAIHWGIK 228
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 68-326 5.94e-98

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 288.39  E-value: 5.94e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536   68 VYQVFESVAKKYDVMNDMMSLGIHRVWKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFlnyvqsqhqrKQKRQLRAQqnls 147
Cdd:TIGR01934   1 VQEMFDRIAPKYDLLNDLLSFGLHRLWRRRAVKLIGVFKGQKVLDVACGTGDLAIEL----------AKSAPDRGK---- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  148 weeiakeyqneedslggsrVVVCDINKEMLKVGKQKALAQgyrAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQ 227
Cdd:TIGR01934  67 -------------------VTGVDFSSEMLEVAKKKSELP---LNIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQK 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  228 ALQEAHRVLKPGGRFLCLEFSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDAGFH 307
Cdd:TIGR01934 125 ALREMYRVLKPGGRLVILEFSKPANALLKKFYKFYLKNVLPSIGGLISKNAEAYTYLPESIRAFPSQEELAAMLKEAGFE 204

                         250
                  ....*....|....*....
gi 116063536  308 KVTYESLTSGIVAIHSGFK 326
Cdd:TIGR01934 205 EVRYRSLTFGVAAIHVGKK 223
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 72-258 2.15e-32

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 117.40  E-value: 2.15e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  72 FESVAKKYDVmndmmslgihrvwKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFLNYvqsqhqrkqkrqlraqqnlsweei 151
Cdd:COG2226    1 FDRVAARYDG-------------REALLAALGLRPGARVLDLGCGTGRLALALAER------------------------ 43

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 152 akeyqneedslgGSRVVVCDINKEMLKVGKQKALAQGYRagLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQE 231
Cdd:COG2226   44 ------------GARVTGVDISPEMLELARERAAEAGLN--VEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAE 109

                        170       180
                 ....*....|....*....|....*..
gi 116063536 232 AHRVLKPGGRFLCLEFSQVNNPLISRL 258
Cdd:COG2226  110 IARVLKPGGRLVVVDFSPPDLAELEEL 136
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 161-244 2.20e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 65.53  E-value: 2.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 161 SLGGSRVVVCDINKEMLKVGKQKALAQGYRaGLAWVLGDAEELPFD-DDKFD-IYTIAFGIRNVTHIDQALQEAHRVLKP 238
Cdd:cd02440   18 SGPGARVTGVDISPVALELARKAAAALLAD-NVEVLKGDAEELPPEaDESFDvIISDPPLHHLVEDLARFLEEARRLLKP 96


                 ....*.
gi 116063536 239 GGRFLC 244
Cdd:cd02440   97 GGVLVL 102
 
Name Accession Description Interval E-value
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 56-327 9.41e-126

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 359.47  E-value: 9.41e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  56 FETVSEEEKGGKVYQVFESVAKKYDVMNDMMSLGIHRVWKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFLNYVQSQhqrk 135
Cdd:PRK00216   1 FMTVAEEEKQEKVAEMFDSIAPKYDLMNDLLSFGLHRVWRRKTIKWLGVRPGDKVLDLACGTGDLAIALAKAVGKT---- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 136 qkrqlraqqnlsweeiakeyqneedslggSRVVVCDINKEMLKVGKQKALAQGYRAGLAWVLGDAEELPFDDDKFDIYTI 215
Cdd:PRK00216  77 -----------------------------GEVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGDAEALPFPDNSFDAVTI 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 216 AFGIRNVTHIDQALQEAHRVLKPGGRFLCLEFSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQE 295
Cdd:PRK00216 128 AFGLRNVPDIDKALREMYRVLKPGGRLVILEFSKPTNPPLKKAYDFYLFKVLPLIGKLISKNAEAYSYLAESIRAFPDQE 207

                        250       260       270
                 ....*....|....*....|....*....|..
gi 116063536 296 EFKDMIEDAGFHKVTYESLTSGIVAIHSGFKL 327
Cdd:PRK00216 208 ELAAMLEEAGFERVRYRNLTGGIVALHVGYKP 239
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
67-326 5.30e-101

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 296.27  E-value: 5.30e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536   67 KVYQVFESVAKKYDVMNDMMSLGIHRVWKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFLNYVQSQhqrkqkrqlraqqnl 146
Cdd:pfam01209   3 RVGDVFSSVASKYDLMNDVISFGIHRLWKDFTMKCMGVKRGNKFLDVAGGTGDWTFGLSDSAGSS--------------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  147 sweeiakeyqneedslggSRVVVCDINKEMLKVGKQKALAQGYRaGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHID 226
Cdd:pfam01209  68 ------------------GKVVGLDINENMLKEGEKKAKEEGKY-NIEFLQGNAEELPFEDDSFDIVTISFGLRNFPDYL 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  227 QALQEAHRVLKPGGRFLCLEFSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDAGF 306
Cdd:pfam01209 129 KVLKEAFRVLKPGGRVVCLEFSKPENPLLSQAYELYFKYVMPFMGKMFAKSYKSYQYLQESIRDFPDQKTLASMFEKAGF 208

                         250       260
                  ....*....|....*....|
gi 116063536  307 HKVTYESLTSGIVAIHSGFK 326
Cdd:pfam01209 209 KSVGYESLTGGIAAIHWGIK 228
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 68-326 5.94e-98

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 288.39  E-value: 5.94e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536   68 VYQVFESVAKKYDVMNDMMSLGIHRVWKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFlnyvqsqhqrKQKRQLRAQqnls 147
Cdd:TIGR01934   1 VQEMFDRIAPKYDLLNDLLSFGLHRLWRRRAVKLIGVFKGQKVLDVACGTGDLAIEL----------AKSAPDRGK---- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  148 weeiakeyqneedslggsrVVVCDINKEMLKVGKQKALAQgyrAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQ 227
Cdd:TIGR01934  67 -------------------VTGVDFSSEMLEVAKKKSELP---LNIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQK 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  228 ALQEAHRVLKPGGRFLCLEFSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDAGFH 307
Cdd:TIGR01934 125 ALREMYRVLKPGGRLVILEFSKPANALLKKFYKFYLKNVLPSIGGLISKNAEAYTYLPESIRAFPSQEELAAMLKEAGFE 204

                         250
                  ....*....|....*....
gi 116063536  308 KVTYESLTSGIVAIHSGFK 326
Cdd:TIGR01934 205 EVRYRSLTFGVAAIHVGKK 223
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 72-258 2.15e-32

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 117.40  E-value: 2.15e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  72 FESVAKKYDVmndmmslgihrvwKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFLNYvqsqhqrkqkrqlraqqnlsweei 151
Cdd:COG2226    1 FDRVAARYDG-------------REALLAALGLRPGARVLDLGCGTGRLALALAER------------------------ 43

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 152 akeyqneedslgGSRVVVCDINKEMLKVGKQKALAQGYRagLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQE 231
Cdd:COG2226   44 ------------GARVTGVDISPEMLELARERAAEAGLN--VEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAE 109

                        170       180
                 ....*....|....*....|....*..
gi 116063536 232 AHRVLKPGGRFLCLEFSQVNNPLISRL 258
Cdd:COG2226  110 IARVLKPGGRLVVVDFSPPDLAELEEL 136
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 71-319 1.06e-29

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 113.83  E-value: 1.06e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  71 VFESVAKKYDVMNDMMSLGIHRVWKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFLNYVQSQhqrkqkrqlraqqnlswee 150
Cdd:PLN02233  38 LFNRIAPVYDNLNDLLSLGQHRIWKRMAVSWSGAKMGDRVLDLCCGSGDLAFLLSEKVGSD------------------- 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 151 iakeyqneedslggSRVVVCDINKEMLKVG--KQKALAQGYRAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQA 228
Cdd:PLN02233  99 --------------GKVMGLDFSSEQLAVAasRQELKAKSCYKNIEWIEGDATDLPFDDCYFDAITMGYGLRNVVDRLKA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 229 LQEAHRVLKPGGRFLCLEFSQVNNPLISRLYD-LYSFQVIPVlgEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDAGFH 307
Cdd:PLN02233 165 MQEMYRVLKPGSRVSILDFNKSTQPFTTSMQEwMIDNVVVPV--ATGYGLAKEYEYLKSSINEYLTGEELEKLALEAGFS 242

                        250
                 ....*....|..
gi 116063536 308 KVTYESLTSGIV 319
Cdd:PLN02233 243 SAKHYEISGGLM 254
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 111-240 6.63e-21

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 85.69  E-value: 6.63e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  111 LDVAGGTGDIAFRFLNyvqsqhqrkqkrqlraqqnlsweeiakeyqneedsLGGSRVVVCDINKEMLKVGKQKALAQGYR 190
Cdd:pfam13649   2 LDLGCGTGRLTLALAR-----------------------------------RGGARVTGVDLSPEMLERARERAAEAGLN 46

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 116063536  191 AglAWVLGDAEELPFDDDKFDIYTIAFGIRNVTH--IDQALQEAHRVLKPGG 240
Cdd:pfam13649  47 V--EFVQGDAEDLPFPDGSFDLVVSSGVLHHLPDpdLEAALREIARVLKPGG 96
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 164-244 8.01e-20

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 82.71  E-value: 8.01e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  164 GSRVVVCDINKEMLKVGKQKAlaqgYRAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRFL 243
Cdd:pfam08241  18 GARVTGVDISPEMLELAREKA----PREGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERALREIARVLKPGGILI 93


                  .
gi 116063536  244 C 244
Cdd:pfam08241  94 I 94
PLN02232 PLN02232
ubiquinone biosynthesis methyltransferase
 171-320 1.59e-18

ubiquinone biosynthesis methyltransferase


Pssm-ID: 165876  Cd Length: 160  Bit Score: 81.27  E-value: 1.59e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 171 DINKEMLKVG--KQKALAQGYRAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLCLEFS 248
Cdd:PLN02232   4 DFSSEQLAVAatRQSLKARSCYKCIEWIEGDAIDLPFDDCEFDAVTMGYGLRNVVDRLRAMKEMYRVLKPGSRVSILDFN 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 116063536 249 QVNNPLISRLYD-LYSFQVIPVlgEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDAGFHKVTYESLTSGIVA 320
Cdd:PLN02232  84 KSNQSVTTFMQGwMIDNVVVPV--ATVYDLAKEYEYLKYSINGYLTGEELETLALEAGFSSACHYEISGGFMG 154
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 85-243 1.00e-14

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 69.66  E-value: 1.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  85 MMSLGIHRVWKDLL--LWKMHPLPGTQLLDVAGGTGDIAFRFlnyvqsqhqrkqkrqlrAQQnlsweeiakeyqneedsl 162
Cdd:COG2227    1 MSDPDARDFWDRRLaaLLARLLPAGGRVLDVGCGTGRLALAL-----------------ARR------------------ 45

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 163 gGSRVVVCDINKEMLKVGKQKALaqgyRAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRF 242
Cdd:COG2227   46 -GADVTGVDISPEALEIARERAA----ELNVDFVQGDLEDLPLEDGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLL 120


                 .
gi 116063536 243 L 243
Cdd:COG2227  121 L 121
PRK08317 PRK08317
hypothetical protein; Provisional
 102-247 7.78e-14

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 69.97  E-value: 7.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 102 MHPLPGTQLLDVAGGTGDIAFrflnyvqsqhqrkqkrqlraqqnlsweEIAKEYQNEedslggSRVVVCDINKEMLKVGK 181
Cdd:PRK08317  15 LAVQPGDRVLDVGCGPGNDAR---------------------------ELARRVGPE------GRVVGIDRSEAMLALAK 61

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116063536 182 QKALAQGYRAglAWVLGDAEELPFDDDKFDIytiAFGIRNVTHI---DQALQEAHRVLKPGGRFLCLEF 247
Cdd:PRK08317  62 ERAAGLGPNV--EFVRGDADGLPFPDGSFDA---VRSDRVLQHLedpARALAEIARVLRPGGRVVVLDT 125
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 161-244 2.20e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 65.53  E-value: 2.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 161 SLGGSRVVVCDINKEMLKVGKQKALAQGYRaGLAWVLGDAEELPFD-DDKFD-IYTIAFGIRNVTHIDQALQEAHRVLKP 238
Cdd:cd02440   18 SGPGARVTGVDISPVALELARKAAAALLAD-NVEVLKGDAEELPPEaDESFDvIISDPPLHHLVEDLARFLEEARRLLKP 96


                 ....*.
gi 116063536 239 GGRFLC 244
Cdd:cd02440   97 GGVLVL 102
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 96-243 2.46e-11

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 61.10  E-value: 2.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  96 DLLLWKMHPLPGTQLLDVAGGTGDIAFRFlnyvqsqhqrkqkrqlraqqnlsweeiAKEYqneedslgGSRVVVCDINKE 175
Cdd:COG2230   41 DLILRKLGLKPGMRVLDIGCGWGGLALYL---------------------------ARRY--------GVRVTGVTLSPE 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 116063536 176 MLKVGKQKALAQGYRAGLAWVLGDAEELPFdDDKFD-IYTI----AFGIRNvthIDQALQEAHRVLKPGGRFL 243
Cdd:COG2230   86 QLEYARERAAEAGLADRVEVRLADYRDLPA-DGQFDaIVSIgmfeHVGPEN---YPAYFAKVARLLKPGGRLL 154
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 106-248 3.60e-11

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 60.51  E-value: 3.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  106 PGTQLLDVAGGTGDIAFRFLNYVQSQhqrkqkrqlraqqnlsweeiakeyqneedslggSRVVVCDINKEMLKVGKQKAL 185
Cdd:pfam13847   3 KGMRVLDLGCGTGHLSFELAEELGPN---------------------------------AEVVGIDISEEAIEKARENAQ 49

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 116063536  186 AQGYrAGLAWVLGDAEELP--FDDDKFDIyTIAFGIRN-VTHIDQALQEAHRVLKPGGRFLCLEFS 248
Cdd:pfam13847  50 KLGF-DNVEFEQGDIEELPelLEDDKFDV-VISNCVLNhIPDPDKVLQEILRVLKPGGRLIISDPD 113
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 111-242 1.64e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 54.30  E-value: 1.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  111 LDVAGGTGDIAFRFLNYvqsqhqrkqkrqlraqqnlsweeiakeyqneedsLGGSRVVVCDINKEMLKVGKQKALAQGYR 190
Cdd:pfam08242   1 LEIGCGTGTLLRALLEA----------------------------------LPGLEYTGLDISPAALEAARERLAALGLL 46

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 116063536  191 AGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRF 242
Cdd:pfam08242  47 NAVRVELFQLDLGELDPGSFDVVVASNVLHHLADPRAVLRNIRRLLKPGGVL 98
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 162-243 7.58e-09

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 54.92  E-value: 7.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 162 LGGSRVVVCDINKEMLKVGKQKALAQGYrAGLAWVLGDAEEL-PFDDDKFDiYTIAFGIrnVTHID-----QALQEAHRV 235
Cdd:COG0500   47 RFGGRVIGIDLSPEAIALARARAAKAGL-GNVEFLVADLAELdPLPAESFD-LVVAFGV--LHHLPpeereALLRELARA 122


                 ....*...
gi 116063536 236 LKPGGRFL 243
Cdd:COG0500  123 LKPGGVLL 130
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 171-297 3.83e-08

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 53.44  E-value: 3.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  171 DINKEMLKVGKQKalaqgYRAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLCLEFSQV 250
Cdd:TIGR02072  65 DISAGMLAQAKTK-----LSENVQFICGDAEKLPLEDSSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGPG 139

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 116063536  251 NNPLISRLYDLYSFQVIPV--LGEVIAGDWKSYQYLVESIR-RFPSQEEF 297
Cdd:TIGR02072 140 TLHELRQSFGQHGLRYLSLdeLKALLKNSFELLTLEEELITlSFDDPLDV 189
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
68-243 8.81e-08

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 51.54  E-value: 8.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  68 VYQVFESVAKKYDvmNDMMSLGIHRVWKDL---LLWKMHPLPGTQLLDVAGGTGDIAFRFLNYvqsqhqrkqkrqlraqq 144
Cdd:COG4976    7 VEALFDQYADSYD--AALVEDLGYEAPALLaeeLLARLPPGPFGRVLDLGCGTGLLGEALRPR----------------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 145 nlsweeiakeyqneedslgGSRVVVCDINKEMLKVGKQKALaqgyraGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTH 224
Cdd:COG4976   68 -------------------GYRLTGVDLSEEMLAKAREKGV------YDRLLVADLADLAEPDGRFDLIVAADVLTYLGD 122

                        170
                 ....*....|....*....
gi 116063536 225 IDQALQEAHRVLKPGGRFL 243
Cdd:COG4976  123 LAAVFAGVARALKPGGLFI 141
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 162-241 1.78e-07

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 50.33  E-value: 1.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 162 LGGSRVVVCDINKEMLKvgkqkalaqGYRAGLAW--------VLGDAEELPFDDDKFDI------YTIAFGI--RNVTHI 225
Cdd:COG1041   46 LLGRRVIGSDIDPKMVE---------GARENLEHygyedadvIRGDARDLPLADESVDAivtdppYGRSSKIsgEELLEL 116

                         90
                 ....*....|....*..
gi 116063536 226 -DQALQEAHRVLKPGGR 241
Cdd:COG1041  117 yEKALEEAARVLKPGGR 133
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
106-243 6.60e-07

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 47.13  E-value: 6.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 106 PGTQLLDVAGGTGDIAfrflnyvqsqhqrkqkRQLRAQqnlsweeiakeyqneedsLGGSRVVVCDINKEMLkvgkqkAL 185
Cdd:COG4106    1 PPRRVLDLGCGTGRLT----------------ALLAER------------------FPGARVTGVDLSPEML------AR 40

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 116063536 186 AQGYRAGLAWVLGDAEELPFDDdKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRFL 243
Cdd:COG4106   41 ARARLPNVRFVVADLRDLDPPE-PFDLVVSNAALHWLPDHAALLARLAAALAPGGVLA 97
arsM PRK11873
arsenite methyltransferase;
171-313 7.25e-07

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 49.95  E-value: 7.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 171 DINKEMLKVGKQKALAQGYrAGLAWVLGDAEELPFDDDKFDIYtiafgIRN-----VTHIDQALQEAHRVLKPGGRFlcl 245
Cdd:PRK11873 109 DMTPEMLAKARANARKAGY-TNVEFRLGEIEALPVADNSVDVI-----ISNcvinlSPDKERVFKEAFRVLKPGGRF--- 179

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116063536 246 efsqvnnpLISrlyDLysfqvipvlgeVIAGDwksyqyLVESIRRFP-----------SQEEFKDMIEDAGFHKVTYES 313
Cdd:PRK11873 180 --------AIS---DV-----------VLRGE------LPEEIRNDAelyagcvagalQEEEYLAMLAEAGFVDITIQP 230
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 167-309 9.29e-07

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 49.89  E-value: 9.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 167 VVVCDINKEMLKVGKQKALAQGYRAglawVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRfLCLe 246
Cdd:PLN02490 140 VTILDQSPHQLAKAKQKEPLKECKI----IEGDAEDLPFPTDYADRYVSAGSIEYWPDPQRGIKEAYRVLKIGGK-ACL- 213

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 116063536 247 fsqvnnplisrlydlysfqvipvLGEVIAGDWKSyQYLVESIRRFPSQEEFKDMIEDAGFHKV 309
Cdd:PLN02490 214 -----------------------IGPVHPTFWLS-RFFADVWMLFPKEEEYIEWFTKAGFKDV 252
PRK05785 PRK05785
hypothetical protein; Provisional
 68-326 1.97e-06

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 48.15  E-value: 1.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536  68 VYQVFESVAKKYDVMNDMMSLGIHRVW-KDL--LLWKMHPLPGtQLLDVAGGTGDIAFRFlnyvqsqhqrkqkrqlraqq 144
Cdd:PRK05785  11 LQEAYNKIPKAYDRANRFISFNQDVRWrAELvkTILKYCGRPK-KVLDVAAGKGELSYHF-------------------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 145 nlsweeiAKEYQNEedslggsrVVVCDINKEMLKVgkqkALAQGYRaglawVLGDAEELPFDDDKFDIYTIAFGIRNVTH 224
Cdd:PRK05785  70 -------KKVFKYY--------VVALDYAENMLKM----NLVADDK-----VVGSFEALPFRDKSFDVVMSSFALHASDN 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063536 225 IDQALQEAHRVLKPGGRFLCLefSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDA 304
Cdd:PRK05785 126 IEKVIAEFTRVSRKQVGFIAM--GKPDNVIKRKYLSFYLRYIMPYIACLAGAKCRDYKYIYYIYERLPTNSFHREIFEKY 203

                        250       260
                 ....*....|....*....|..
gi 116063536 305 GFHKVtYESLTSGIVAIHSGFK 326
Cdd:PRK05785 204 ADIKV-YEERGLGLVYFVVGSS 224
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 164-241 4.90e-06

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 47.06  E-value: 4.90e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116063536 164 GSRVVVCDINKEMLKVGKQKALAQGYraglawVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGR 241
Cdd:PRK10258  64 GSQVTALDLSPPMLAQARQKDAADHY------LAGDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGV 135
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
196-244 6.08e-04

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 39.85  E-value: 6.08e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 116063536 196 VLGDAEE-LPFDDDKFD-IYTiafgiRNV-THIDQ-----ALQEAHRVLKPGGRFLC 244
Cdd:COG4627   32 IVGDLTDpLPFPDNSVDaIYS-----SHVlEHLDYeeaplALKECYRVLKPGGILRI 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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