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Conserved domains on  [gi|14150114|ref|NP_115708|]
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WD repeat domain-containing protein 83 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-295 2.03e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 191.78  E-value: 2.03e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  18 LKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVA 97
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  98 SGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRrpEPVQTLDEARDGVSSVKVSDHE--ILAGSVDGRV 175
Cdd:cd00200  82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGTI 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114 176 RRYDLRMGQLFSDYVG--SPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYklDCCLSERDTHVVSC 253
Cdd:cd00200 160 KLWDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVN--SVAFSPDGYLLASG 237

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 14150114 254 SEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTA 295
Cdd:cd00200 238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG 279
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-295 2.03e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 191.78  E-value: 2.03e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  18 LKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVA 97
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  98 SGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRrpEPVQTLDEARDGVSSVKVSDHE--ILAGSVDGRV 175
Cdd:cd00200  82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGTI 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114 176 RRYDLRMGQLFSDYVG--SPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYklDCCLSERDTHVVSC 253
Cdd:cd00200 160 KLWDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVN--SVAFSPDGYLLASG 237

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 14150114 254 SEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTA 295
Cdd:cd00200 238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
16-304 1.10e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 193.59  E-value: 1.10e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  16 KRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWD 95
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  96 VASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRrpEPVQTLDEARDGVSSVKVS-DHEILA-GSVDG 173
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG--KLLRTLTGHSGSVRSVAFSpDGRLLAsGSADG 268

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114 174 RVRRYDLRMGQLFSDYVG--SPITCTCFSRDGQcTLVS-SLDSTLRLLDKDTGELLGEYKGHKNQEYKLdcCLSERDTHV 250
Cdd:COG2319 269 TVRLWDLATGELLRTLTGhsGGVNSVAFSPDGK-LLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKTL 345

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 14150114 251 VSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTA-MGGSVQCWR 304
Cdd:COG2319 346 ASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGsADGTVRLWD 400
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 28-307 7.62e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.88  E-value: 7.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114   28 VRAVRFNVDGNYCLTCGSDKTLKLWNPlrGTLLRTYSGHGYEVLDAAGSFDNSSLC----------SGGGDKAVVLWDVA 97
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFEC--ESIIKDGRDIHYPVVELASRSKLSGICwnsyiksqvaSSNFEGVVQVWDVA 563

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114   98 SGQVVRKFRGHAGKVNTVQFNE-EATVILSGSIDSSIRCWDCrsRRPEPVQTLdEARDGVSSVKV---SDHEILAGSVDG 173
Cdd:PLN00181 564 RSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSI--NQGVSIGTI-KTKANICCVQFpseSGRSLAFGSADH 640

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  174 RVRRYDLRMGQL-FSDYVGSPITCTCFSRDGQCTLV-SSLDSTLRLLDKDTG------ELLGEYKGHKNqeYKLDCCLSE 245
Cdd:PLN00181 641 KVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTLVsSSTDNTLKLWDLSMSisgineTPLHSFMGHTN--VKNFVGLSV 718

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 14150114  246 RDTHVVSCSEDGKVFFWDlvegaLALALPvgsgvVQSLAYHPTEPCLLTAMGGSVQ-----CWREEA 307
Cdd:PLN00181 719 SDGYIATGSETNEVFVYH-----KAFPMP-----VLSYKFKTIDPVSGLEVDDASQfissvCWRGQS 775
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-137 1.82e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 1.82e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 14150114     98 SGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWD 137
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
99-137 1.72e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 1.72e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 14150114    99 GQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWD 137
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-295 2.03e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 191.78  E-value: 2.03e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  18 LKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVA 97
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  98 SGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRrpEPVQTLDEARDGVSSVKVSDHE--ILAGSVDGRV 175
Cdd:cd00200  82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGTI 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114 176 RRYDLRMGQLFSDYVG--SPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYklDCCLSERDTHVVSC 253
Cdd:cd00200 160 KLWDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVN--SVAFSPDGYLLASG 237

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 14150114 254 SEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTA 295
Cdd:cd00200 238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
16-304 1.10e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 193.59  E-value: 1.10e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  16 KRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWD 95
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  96 VASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRrpEPVQTLDEARDGVSSVKVS-DHEILA-GSVDG 173
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG--KLLRTLTGHSGSVRSVAFSpDGRLLAsGSADG 268

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114 174 RVRRYDLRMGQLFSDYVG--SPITCTCFSRDGQcTLVS-SLDSTLRLLDKDTGELLGEYKGHKNQEYKLdcCLSERDTHV 250
Cdd:COG2319 269 TVRLWDLATGELLRTLTGhsGGVNSVAFSPDGK-LLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKTL 345

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 14150114 251 VSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTA-MGGSVQCWR 304
Cdd:COG2319 346 ASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGsADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
16-264 7.47e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.18  E-value: 7.47e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  16 KRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWD 95
Cdd:COG2319 153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  96 VASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRrpEPVQTLDEARDGVSSVKVS-DHEILA-GSVDG 173
Cdd:COG2319 233 LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG--ELLRTLTGHSGGVNSVAFSpDGKLLAsGSDDG 310

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114 174 RVRRYDLRMGQLFSDYVG--SPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYklDCCLSERDTHVV 251
Cdd:COG2319 311 TVRLWDLATGKLLRTLTGhtGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT--SVAFSPDGRTLA 388

                       250
                ....*....|...
gi 14150114 252 SCSEDGKVFFWDL 264
Cdd:COG2319 389 SGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
12-304 3.61e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.94  E-value: 3.61e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  12 ELPQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAV 91
Cdd:COG2319  65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  92 VLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRpePVQTLDEARDGVSSVKVS-DHEILA-G 169
Cdd:COG2319 145 RLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSpDGKLLAsG 222

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114 170 SVDGRVRRYDLRMGQLFSDYVG--SPITCTCFSRDGQcTLVS-SLDSTLRLLDKDTGELLGEYKGHKNQEYKLdcCLSER 246
Cdd:COG2319 223 SADGTVRLWDLATGKLLRTLTGhsGSVRSVAFSPDGR-LLASgSADGTVRLWDLATGELLRTLTGHSGGVNSV--AFSPD 299

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 14150114 247 DTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTA-MGGSVQCWR 304
Cdd:COG2319 300 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGsDDGTVRLWD 358
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-263 1.57e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 161.35  E-value: 1.57e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  25 QGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRK 104
Cdd:cd00200  51 TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTT 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114 105 FRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPepVQTLDEARDGVSSVKVSD--HEILAGSVDGRVRRYDLRM 182
Cdd:cd00200 131 LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC--VATLTGHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLST 208

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114 183 GQLFSDYVG--SPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCclSERDTHVVSCSEDGKVF 260
Cdd:cd00200 209 GKCLGTLRGheNGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAW--SPDGKRLASGSADGTIR 286


                ...
gi 14150114 261 FWD 263
Cdd:cd00200 287 IWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
24-303 2.45e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.54  E-value: 2.45e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  24 GQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVR 103
Cdd:COG2319  35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114 104 KFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDcrSRRPEPVQTLDEARDGVSSVKVS-DHEILA-GSVDGRVRRYDLR 181
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD--LATGKLLRTLTGHSGAVTSVAFSpDGKLLAsGSDDGTVRLWDLA 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114 182 MGQLFSDYVG--SPITCTCFSRDGQcTLVS-SLDSTLRLLDKDTGELLGEYKGHKNQEYKLDccLSERDTHVVSCSEDGK 258
Cdd:COG2319 193 TGKLLRTLTGhtGAVRSVAFSPDGK-LLASgSADGTVRLWDLATGKLLRTLTGHSGSVRSVA--FSPDGRLLASGSADGT 269

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 14150114 259 VFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTA-MGGSVQCW 303
Cdd:COG2319 270 VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGsDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
16-222 8.89e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.99  E-value: 8.89e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  16 KRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWD 95
Cdd:COG2319 195 KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  96 VASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPepVQTLDEARDGVSSVKVS--DHEILAGSVDG 173
Cdd:COG2319 275 LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL--LRTLTGHTGAVRSVAFSpdGKTLASGSDDG 352

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 14150114 174 RVRRYDLRMGQLFSDYVG--SPITCTCFSRDGQCTLVSSLDSTLRLLDKDT 222
Cdd:COG2319 353 TVRLWDLATGELLRTLTGhtGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-217 1.31e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 135.16  E-value: 1.31e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  16 KRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWD 95
Cdd:cd00200  84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  96 VASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRpePVQTLDEARDGVSSVKVSDHE--ILAGSVDG 173
Cdd:cd00200 164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK--CLGTLRGHENGVNSVAFSPDGylLASGSEDG 241

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 14150114 174 RVRRYDLRMGQLFSDYVG--SPITCTCFSRDGQCTLVSSLDSTLRL 217
Cdd:cd00200 242 TIRVWDLRTGECVQTLSGhtNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-304 9.76e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 132.84  E-value: 9.76e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  59 LLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDc 138
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114 139 rSRRPEPVQTLDEARDGVSSVKVSDHE--ILAGSVDGRVRRYDLRMGQLFSDYVG--SPITCTCFSRDGQCTLVSSLDST 214
Cdd:cd00200  80 -LETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGhtDWVNSVAFSPDGTFVASSSQDGT 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114 215 LRLLDKDTGELLGEYKGHKNQEYKldCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLT 294
Cdd:cd00200 159 IKLWDLRTGKCVATLTGHTGEVNS--VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                       250
                ....*....|.
gi 14150114 295 A-MGGSVQCWR 304
Cdd:cd00200 237 GsEDGTIRVWD 247
WD40 COG2319
WD40 repeat [General function prediction only];
32-304 8.86e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.11  E-value: 8.86e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  32 RFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGK 111
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114 112 VNTVQFNEEATVILSGSIDSSIRCWDCRSRRpePVQTLDEARDGVSSVKVS-DHEILA-GSVDGRVRRYDLRMGQLFSDY 189
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGL--LLRTLTGHTGAVRSVAFSpDGKTLAsGSADGTVRLWDLATGKLLRTL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114 190 VG--SPITCTCFSRDGQcTLVS-SLDSTLRLLDKDTGELLGEYKGHKNQEYKLdcCLSERDTHVVSCSEDGKVFFWDLVE 266
Cdd:COG2319 159 TGhsGAVTSVAFSPDGK-LLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKLLASGSADGTVRLWDLAT 235

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 14150114 267 GALALALPVGSGVVQSLAYHPTEPCLLTAMG-GSVQCWR 304
Cdd:COG2319 236 GKLLRTLTGHSGSVRSVAFSPDGRLLASGSAdGTVRLWD 274
WD40 COG2319
WD40 repeat [General function prediction only];
15-181 1.51e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.34  E-value: 1.51e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  15 QKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLW 94
Cdd:COG2319 236 GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  95 DVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRrpEPVQTLDEARDGVSSVKVS-DHEILA-GSVD 172
Cdd:COG2319 316 DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG--ELLRTLTGHTGAVTSVAFSpDGRTLAsGSAD 393


                ....*....
gi 14150114 173 GRVRRYDLR 181
Cdd:COG2319 394 GTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-137 4.81e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.95  E-value: 4.81e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  16 KRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWD 95
Cdd:cd00200 168 KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 14150114  96 VASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWD 137
Cdd:cd00200 248 LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 28-307 7.62e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.88  E-value: 7.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114   28 VRAVRFNVDGNYCLTCGSDKTLKLWNPlrGTLLRTYSGHGYEVLDAAGSFDNSSLC----------SGGGDKAVVLWDVA 97
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFEC--ESIIKDGRDIHYPVVELASRSKLSGICwnsyiksqvaSSNFEGVVQVWDVA 563

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114   98 SGQVVRKFRGHAGKVNTVQFNE-EATVILSGSIDSSIRCWDCrsRRPEPVQTLdEARDGVSSVKV---SDHEILAGSVDG 173
Cdd:PLN00181 564 RSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSI--NQGVSIGTI-KTKANICCVQFpseSGRSLAFGSADH 640

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  174 RVRRYDLRMGQL-FSDYVGSPITCTCFSRDGQCTLV-SSLDSTLRLLDKDTG------ELLGEYKGHKNqeYKLDCCLSE 245
Cdd:PLN00181 641 KVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTLVsSSTDNTLKLWDLSMSisgineTPLHSFMGHTN--VKNFVGLSV 718

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 14150114  246 RDTHVVSCSEDGKVFFWDlvegaLALALPvgsgvVQSLAYHPTEPCLLTAMGGSVQ-----CWREEA 307
Cdd:PLN00181 719 SDGYIATGSETNEVFVYH-----KAFPMP-----VLSYKFKTIDPVSGLEVDDASQfissvCWRGQS 775
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-137 1.82e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 1.82e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 14150114     98 SGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWD 137
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
99-137 1.72e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 1.72e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 14150114    99 GQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWD 137
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 14-53 2.93e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 2.93e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 14150114     14 PQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWN 53
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
16-53 6.29e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 6.29e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 14150114    16 KRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWN 53
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 222-263 9.42e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 9.42e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 14150114    222 TGELLGEYKGHKNqeYKLDCCLSERDTHVVSCSEDGKVFFWD 263
Cdd:smart00320   1 SGELLKTLKGHTG--PVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 44-189 2.08e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 2.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114   44 GSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAG----------KVN 113
Cdd:PTZ00421 145 GADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASaksqrclwakRKD 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114  114 TVqfneeATVILSGSIDSSIRCWDCRsRRPEPVQTLDEARDGVSSVKVSDHE----ILAGSVDGRVRRYDLRMGQLFSDY 189
Cdd:PTZ00421 225 LI-----ITLGCSKSQQRQIMLWDTR-KMASPYSTVDLDQSSALFIPFFDEDtnllYIGSKGEGNIRCFELMNERLTFCS 298
WD40 pfam00400
WD domain, G-beta repeat;
57-95 2.58e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 2.58e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 14150114    57 GTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWD 95
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 57-95 4.73e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 4.73e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 14150114     57 GTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWD 95
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 118-226 1.37e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 39.90  E-value: 1.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14150114 118 NEEATVILSGSIDSSIRCWDCRS-RRP--------EPVQTLDEARDGvssvkvsdHEILAGSVDGRVRRYDLRMGQLFSD 188
Cdd:cd22857 189 KDDHRKIVTGTGYHQVRLYDTRAqRRPvvsvdfgeTPIKAVAEDPDG--------HTVYVGDTSGDLASIDLRTGKLLGC 260

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 14150114 189 YVG---SPITCTcfSRDGQCTLVSS--LDSTLRLLDKDTGELL 226
Cdd:cd22857 261 FKGkcgGSIRSI--ARHPELPLIAScgLDRYLRIWDTETRQLL 301
WD40 pfam00400
WD domain, G-beta repeat;
223-263 4.15e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 4.15e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 14150114   223 GELLGEYKGHKNQEYklDCCLSERDTHVVSCSEDGKVFFWD 263
Cdd:pfam00400   1 GKLLKTLEGHTGSVT--SLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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