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Conserved domains on  [gi|156523235|ref|NP_115872|]
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phospholipid phosphatase 5 isoform 2 [Homo sapiens]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130247)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to mammalian phospholipid phosphatases that catalyzes the conversion of phosphatidic acid to diacylglycerol

EC:  3.1.3.-
Gene Ontology:  GO:0006644|GO:0008195|GO:0046839
PubMed:  12447906

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 43-211 3.95e-68

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


:

Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 207.07  E-value: 3.95e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235  43 WLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRC 122
Cdd:cd03390    1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235 123 FPDGLAHSDLM------CTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPqgRGKSWRFCAFLSPLLFAA 196
Cdd:cd03390   81 FPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDP--RGSSWRLLLALLPLLLAI 158

                        170
                 ....*....|....*
gi 156523235 197 VIALSRTCDYKHHWQ 211
Cdd:cd03390  159 LVAVSRTRDYRHHFS 173
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 43-211 3.95e-68

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 207.07  E-value: 3.95e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235  43 WLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRC 122
Cdd:cd03390    1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235 123 FPDGLAHSDLM------CTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPqgRGKSWRFCAFLSPLLFAA 196
Cdd:cd03390   81 FPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDP--RGSSWRLLLALLPLLLAI 158

                        170
                 ....*....|....*
gi 156523235 197 VIALSRTCDYKHHWQ 211
Cdd:cd03390  159 LVAVSRTRDYRHHFS 173
PLN02250 PLN02250
lipid phosphate phosphatase
 25-214 5.15e-47

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 157.01  E-value: 5.15e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235  25 LVTELLPPFQRLIQPEEMWLYRNPyVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKaDTRDSRQACLAASLALALNGVFT 104
Cdd:PLN02250  37 VVLNVIEPFHRFVGKDMLTDLSYP-LQDNTIPFWAVPLIAILLPFAVILVYYFIRR-DVYDLHHAILGLLFSVLITGVIT 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235 105 NTIKLIVGRPRPDFFYRCFPDGLA-----HSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFtpQGR 179
Cdd:PLN02250 115 DAIKDAVGRPRPDFFWRCFPDGKGvfhpvTTDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLSLYLSGKIRVF--DRR 192

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 156523235 180 GKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQGPF 214
Cdd:PLN02250 193 GHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVF 227
acidPPc smart00014
Acid phosphatase homologues;
103-210 3.15e-16

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 71.61  E-value: 3.15e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235   103 FTNTIKLIVGRPRPDFFYRCfpdglahsDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLagklhcftpQGRGKS 182
Cdd:smart00014  10 FNGVIKNYFGRPRPFFLSIG--------DACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYL---------PARAGR 72

                           90       100
                   ....*....|....*....|....*...
gi 156523235   183 WRFCAFLspLLFAAVIALSRTCDYKHHW 210
Cdd:smart00014  73 KLLIFLL--LLLALVVGFSRVYLGAHWP 98
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 101-210 2.44e-15

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 69.37  E-value: 2.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235  101 GVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMctgdkdvvnEGRKSFPSGHSSFAFAGLAFASFYLAgklhcftpqGRG 180
Cdd:pfam01569  10 GLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLP---------GLGYSFPSGHSATAFALALLLALLLR---------RLR 71

                          90       100       110
                  ....*....|....*....|....*....|
gi 156523235  181 KSWRFCAFLSPLLFAAVIALSRTCDYKHHW 210
Cdd:pfam01569  72 KIVRVLLALLLLVLALLVGLSRLYLGVHFP 101
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 18-202 1.08e-06

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 47.34  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235  18 LALFAAFLVTELLPPFQRLIQPEEMWLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLAL 97
Cdd:COG0671    3 LALLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235  98 ALNGVFTNTIKLIVGRPRPdFFYRCFPDGLAHSDlmctgdkdvvnegRKSFPSGHSSFAFAGLAFASFYLagklhcftpq 177
Cdd:COG0671   83 LLLLLLLLLLKYLFGRPRP-FVVPDLELLLGTAG-------------GYSFPSGHAAAAFALALVLALLL---------- 138

                        170       180
                 ....*....|....*....|....*
gi 156523235 178 grgksWRFCAFLSPLLFAAVIALSR 202
Cdd:COG0671  139 -----PRRWLAALLLALALLVGLSR 158
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 43-211 3.95e-68

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 207.07  E-value: 3.95e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235  43 WLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRC 122
Cdd:cd03390    1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235 123 FPDGLAHSDLM------CTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPqgRGKSWRFCAFLSPLLFAA 196
Cdd:cd03390   81 FPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDP--RGSSWRLLLALLPLLLAI 158

                        170
                 ....*....|....*
gi 156523235 197 VIALSRTCDYKHHWQ 211
Cdd:cd03390  159 LVAVSRTRDYRHHFS 173
PLN02250 PLN02250
lipid phosphate phosphatase
 25-214 5.15e-47

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 157.01  E-value: 5.15e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235  25 LVTELLPPFQRLIQPEEMWLYRNPyVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKaDTRDSRQACLAASLALALNGVFT 104
Cdd:PLN02250  37 VVLNVIEPFHRFVGKDMLTDLSYP-LQDNTIPFWAVPLIAILLPFAVILVYYFIRR-DVYDLHHAILGLLFSVLITGVIT 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235 105 NTIKLIVGRPRPDFFYRCFPDGLA-----HSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFtpQGR 179
Cdd:PLN02250 115 DAIKDAVGRPRPDFFWRCFPDGKGvfhpvTTDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLSLYLSGKIRVF--DRR 192

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 156523235 180 GKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQGPF 214
Cdd:PLN02250 193 GHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVF 227
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 29-214 4.98e-41

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 142.09  E-value: 4.98e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235  29 LLPPFQRLIQPEEMWLYRNPyVEAEYFPTKPMFVIAFLSPLsLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIK 108
Cdd:PLN02731  60 IIHPFYRFVGKDMMTDLSYP-LKSNTVPIWSVPVYAMLLPL-VIFIFIYFRRRDVYDLHHAVLGLLYSVLVTAVLTDAIK 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235 109 LIVGRPRPDFFYRCFPDGLAH----SDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFtpQGRGKSWR 184
Cdd:PLN02731 138 NAVGRPRPDFFWRCFPDGKALydslGDVICHGDKSVIREGHKSFPSGHTSWSFSGLGFLSLYLSGKIQAF--DGKGHVAK 215

                        170       180       190
                 ....*....|....*....|....*....|
gi 156523235 185 FCAFLSPLLFAAVIALSRTCDYKHHWQGPF 214
Cdd:PLN02731 216 LCIVILPLLFAALVGISRVDDYWHHWQDVF 245
PLN02715 PLN02715
lipid phosphate phosphatase
 29-214 5.63e-35

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 126.32  E-value: 5.63e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235  29 LLPPFQRLIQPEEMWLYRNPYVEaEYFPTKPMFVIAFLSPLsLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIK 108
Cdd:PLN02715  66 LISPFYRYVGKDMMTDLKYPFKD-NTVPIWSVPVYAVLLPI-ILFVCFYLKRRCVYDLHHSILGLLFAVLITGVITDSIK 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235 109 LIVGRPRPDFFYRCFPDGLAHSD----LMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPQGRGKswR 184
Cdd:PLN02715 144 VATGRPRPNFYWRCFPDGKELYDalggVICHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNGEGHVA--K 221

                        170       180       190
                 ....*....|....*....|....*....|
gi 156523235 185 FCAFLSPLLFAAVIALSRTCDYKHHWQGPF 214
Cdd:PLN02715 222 LCLVIFPLLAACLVGISRVDDYWHHWQDVF 251
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 102-210 6.50e-24

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 92.69  E-value: 6.50e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235 102 VFTNTIKLIVGRPRPDFFYRCFPDG----------LAHSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKL 171
Cdd:cd03384   18 LLTDLGKYVTGRLRPHFLDVCKPNYtdltcsldhqYIADCTCCTGDPDLIREARLSFPSGHASLSMYAAVFLALYLQARL 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 156523235 172 hcftpqgrgkSWRFCAFLSPLL------FAAVIALSRTCDYKHHW 210
Cdd:cd03384   98 ----------KLRGSRLLRPLLqflllaLALYVGLSRISDYKHHW 132
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 100-210 6.34e-18

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 76.35  E-value: 6.34e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235 100 NGVFTNTIKLIVGRPRPDFFYRCFPDGlahsdlmctgDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLhcftpqgr 179
Cdd:cd01610   15 GLLLTGVLKYLFGRPRPYFLLRCGPDG----------DPLLLTEGGYSFPSGHAAFAFALALFLALLLPRRL-------- 76

                         90       100       110
                 ....*....|....*....|....*....|.
gi 156523235 180 gksWRFCAFLSPLLFAAVIALSRTCDYKHHW 210
Cdd:cd01610   77 ---LRLLLGLLLLLLALLVGLSRVYLGVHYP 104
acidPPc smart00014
Acid phosphatase homologues;
103-210 3.15e-16

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 71.61  E-value: 3.15e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235   103 FTNTIKLIVGRPRPDFFYRCfpdglahsDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLagklhcftpQGRGKS 182
Cdd:smart00014  10 FNGVIKNYFGRPRPFFLSIG--------DACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYL---------PARAGR 72

                           90       100
                   ....*....|....*....|....*...
gi 156523235   183 WRFCAFLspLLFAAVIALSRTCDYKHHW 210
Cdd:smart00014  73 KLLIFLL--LLLALVVGFSRVYLGAHWP 98
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 101-210 2.44e-15

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 69.37  E-value: 2.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235  101 GVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMctgdkdvvnEGRKSFPSGHSSFAFAGLAFASFYLAgklhcftpqGRG 180
Cdd:pfam01569  10 GLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLP---------GLGYSFPSGHSATAFALALLLALLLR---------RLR 71

                          90       100       110
                  ....*....|....*....|....*....|
gi 156523235  181 KSWRFCAFLSPLLFAAVIALSRTCDYKHHW 210
Cdd:pfam01569  72 KIVRVLLALLLLVLALLVGLSRLYLGVHFP 101
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 101-202 5.65e-08

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 50.69  E-value: 5.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235 101 GVFTNTIKLIVGRPRPDFFYRCFPDGLahsdlmctgdkdvvnegrkSFPSGHSSFAFAGLAFASFYLAGKLHcftpqgrG 180
Cdd:cd03392   75 GALNTLLKLLVQRPRPPLHLLVPEGGY-------------------SFPSGHAMGATVLYGFLAYLLARRLP-------R 128

                         90       100
                 ....*....|....*....|..
gi 156523235 181 KSWRFCAFLSPLLFAAVIALSR 202
Cdd:cd03392  129 RRVRILLLILAAILILLVGLSR 150
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 18-202 1.08e-06

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 47.34  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235  18 LALFAAFLVTELLPPFQRLIQPEEMWLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLAL 97
Cdd:COG0671    3 LALLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235  98 ALNGVFTNTIKLIVGRPRPdFFYRCFPDGLAHSDlmctgdkdvvnegRKSFPSGHSSFAFAGLAFASFYLagklhcftpq 177
Cdd:COG0671   83 LLLLLLLLLLKYLFGRPRP-FVVPDLELLLGTAG-------------GYSFPSGHAAAAFALALVLALLL---------- 138

                        170       180
                 ....*....|....*....|....*
gi 156523235 178 grgksWRFCAFLSPLLFAAVIALSR 202
Cdd:COG0671  139 -----PRRWLAALLLALALLVGLSR 158
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 101-208 2.63e-05

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 43.08  E-value: 2.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235 101 GVFTNTIKLIVGRPRPDFFyrcFPDGLAHSDLMCTGDkdvvneGRKSFPSGHSSFAFAgLAFASFYLAGKlhcftpqgrg 180
Cdd:cd03389   82 GILVNLLKFIIGRARPKLL---FDDGLYGFDPFHADY------AFTSFPSGHSATAGA-AAAALALLFPR---------- 141

                         90       100
                 ....*....|....*....|....*...
gi 156523235 181 ksWRFCAflspLLFAAVIALSRTCDYKH 208
Cdd:cd03389  142 --YRWAF----ILLALLIAFSRVIVGAH 163
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 104-165 5.03e-05

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 41.16  E-value: 5.03e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 156523235 104 TNTIKLIVGRPRPDffyrcfpdglahsdlmctGDkdvvNEGRKSFPSGHSSFAFAGLAFASF 165
Cdd:cd03394   19 TEGLKFAVGRARPD------------------GS----NNGYRSFPSGHTASAFAAATFLQY 58
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 107-209 1.74e-03

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 37.68  E-value: 1.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523235 107 IKLIVGRPRPdffyrcfpdglAHsdlMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHcftpqgrgkswrfc 186
Cdd:cd03391   66 LKALVRRRRP-----------AY---NSPDMLDYVAVDKYSFPSGHASRAAFVARFLLNHLVLAVP-------------- 117

                         90       100
                 ....*....|....*....|....
gi 156523235 187 aFLSPL-LFAAVIALSRTCDYKHH 209
Cdd:cd03391  118 -LRVLLvLWATVVGISRVLLGRHH 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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