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Conserved domains on  [gi|15100175|ref|NP_116130|]
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1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 69-255 1.29e-56

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


:

Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 180.16  E-value: 1.29e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175  69 LRLMLlhikYLYGIRVEVRGAHHFPPSQPYVVVSNHQSSLDLLGMMEVLPGRCVPIAKRELLWAGSAGLACWLAGVIFID 148
Cdd:cd07989   1 LRLLL----RLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPID 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175 149 RKRTGDAISVMSEVAQtLLTQDVRVWVFPEGTRNHNGSMLPFKRGAFHLAVQAQVPIVPIVMSSYQDFYCKKERRFTSGQ 228
Cdd:cd07989  77 RGNGRSAREALREAIE-ALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPGR 155

                       170       180
                ....*....|....*....|....*....
gi 15100175 229 CQVRVLPPVPTEGL--TPDDVPALADRVR 255
Cdd:cd07989 156 VTVRIGEPIPPEGLelAEEDRKELREKVR 184
 
Name Accession Description Interval E-value
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 69-255 1.29e-56

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 180.16  E-value: 1.29e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175  69 LRLMLlhikYLYGIRVEVRGAHHFPPSQPYVVVSNHQSSLDLLGMMEVLPGRCVPIAKRELLWAGSAGLACWLAGVIFID 148
Cdd:cd07989   1 LRLLL----RLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPID 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175 149 RKRTGDAISVMSEVAQtLLTQDVRVWVFPEGTRNHNGSMLPFKRGAFHLAVQAQVPIVPIVMSSYQDFYCKKERRFTSGQ 228
Cdd:cd07989  77 RGNGRSAREALREAIE-ALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPGR 155

                       170       180
                ....*....|....*....|....*....
gi 15100175 229 CQVRVLPPVPTEGL--TPDDVPALADRVR 255
Cdd:cd07989 156 VTVRIGEPIPPEGLelAEEDRKELREKVR 184
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 67-268 2.94e-56

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 180.21  E-value: 2.94e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175  67 KILRLMLLHIKYLYGIRVEVRGAHHFPPSQPYVVVSNHQSSLDLLGMMEVLPGRCVPIAKRELLWAGSAGLACWLAGVIF 146
Cdd:COG0204  14 RLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRALGAIP 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175 147 IDRKRTGDAISVMSEVAQtLLTQDVRVWVFPEGTRNHNGSMLPFKRGAFHLAVQAQVPIVPIVMSSYQDFYCKKeRRFTS 226
Cdd:COG0204  94 VDRSKRRAALRALRQAVE-ALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALPKG-FLPRP 171

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 15100175 227 GQCQVRVLPPVPTEGLTPDDVPALADRVRHSMLTVFREISTD 268
Cdd:COG0204 172 GKVTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLAELRAE 213
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 83-211 1.97e-43

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 144.34  E-value: 1.97e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175    83 RVEVRGAHHFPPSQPYVVVSNHQSSLDLLGMMEVLP---GRCVPIAKRELLWAGSAGLACWLAGVIFIDRKRTGDAISVM 159
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYkrgRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15100175   160 SEVAQtLLTQDVRVWVFPEGTRNHNGSMLPFKRGAFHLAVQAQVPIVPIVMS 211
Cdd:pfam01553  81 EYLVE-LLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAIS 131
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 81-211 2.81e-40

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 136.32  E-value: 2.81e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175    81 GIRVEVRGAHHFPPSQPYVVVSNHQSSLDLLGMMEVLPGRCVPIAKRELLWAGSAGLACWLAGVIFIDRKRTgDAISVMS 160
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENI-RAIATAL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15100175   161 EVAQTLLTQDVRVWVFPEGTRNHNGSMLPFKRGAFHLAVQAQVPIVPIVMS 211
Cdd:TIGR00530  80 KAAIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 98-211 1.52e-35

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 123.62  E-value: 1.52e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175     98 YVVVSNHQSSLDLLGMMEVLP---GRCVPIAKRELLWAGSAGLACWLAGVIFIDRKRTGDAISVMSEVAQtLLTQDVRVW 174
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPrklGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVE-LLKEGEWLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 15100175    175 VFPEGTRNHNGSMLPFKRGAFHLAVQAQVPIVPIVMS 211
Cdd:smart00563  80 IFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIR 116
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 34-258 1.22e-28

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 109.72  E-value: 1.22e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175   34 YFFKMAFYNGWILFLAVLAIPVCAVRGRNVENMKILRLMLLHIKYLYGIRVEVRGAHHFPPSQPYVVVSNHQSSLDLLGM 113
Cdd:PRK15018   3 YIFRLIITVIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMVTA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175  114 MEVLPGRCVPIAKRELLWAGSAGLACWLAGVIFIDRKRTGDAISVMSEVAQTLLTQDVRVWVFPEGTRNHNGSMLPFKRG 193
Cdd:PRK15018  83 SNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFKTG 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15100175  194 AFHLAVQAQVPIVPIVMSSYQDFYckKERRFTSGQCQVRVLPPVPTEGLTPDDVPALADRVRHSM 258
Cdd:PRK15018 163 AFHAAIAAGVPIIPVCVSTTSNKI--NLNRLHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIM 225
 
Name Accession Description Interval E-value
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 69-255 1.29e-56

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 180.16  E-value: 1.29e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175  69 LRLMLlhikYLYGIRVEVRGAHHFPPSQPYVVVSNHQSSLDLLGMMEVLPGRCVPIAKRELLWAGSAGLACWLAGVIFID 148
Cdd:cd07989   1 LRLLL----RLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPID 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175 149 RKRTGDAISVMSEVAQtLLTQDVRVWVFPEGTRNHNGSMLPFKRGAFHLAVQAQVPIVPIVMSSYQDFYCKKERRFTSGQ 228
Cdd:cd07989  77 RGNGRSAREALREAIE-ALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPGR 155

                       170       180
                ....*....|....*....|....*....
gi 15100175 229 CQVRVLPPVPTEGL--TPDDVPALADRVR 255
Cdd:cd07989 156 VTVRIGEPIPPEGLelAEEDRKELREKVR 184
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 67-268 2.94e-56

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 180.21  E-value: 2.94e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175  67 KILRLMLLHIKYLYGIRVEVRGAHHFPPSQPYVVVSNHQSSLDLLGMMEVLPGRCVPIAKRELLWAGSAGLACWLAGVIF 146
Cdd:COG0204  14 RLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRALGAIP 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175 147 IDRKRTGDAISVMSEVAQtLLTQDVRVWVFPEGTRNHNGSMLPFKRGAFHLAVQAQVPIVPIVMSSYQDFYCKKeRRFTS 226
Cdd:COG0204  94 VDRSKRRAALRALRQAVE-ALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALPKG-FLPRP 171

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 15100175 227 GQCQVRVLPPVPTEGLTPDDVPALADRVRHSMLTVFREISTD 268
Cdd:COG0204 172 GKVTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLAELRAE 213
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 83-211 1.97e-43

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 144.34  E-value: 1.97e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175    83 RVEVRGAHHFPPSQPYVVVSNHQSSLDLLGMMEVLP---GRCVPIAKRELLWAGSAGLACWLAGVIFIDRKRTGDAISVM 159
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYkrgRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15100175   160 SEVAQtLLTQDVRVWVFPEGTRNHNGSMLPFKRGAFHLAVQAQVPIVPIVMS 211
Cdd:pfam01553  81 EYLVE-LLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAIS 131
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 81-211 2.81e-40

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 136.32  E-value: 2.81e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175    81 GIRVEVRGAHHFPPSQPYVVVSNHQSSLDLLGMMEVLPGRCVPIAKRELLWAGSAGLACWLAGVIFIDRKRTgDAISVMS 160
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENI-RAIATAL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15100175   161 EVAQTLLTQDVRVWVFPEGTRNHNGSMLPFKRGAFHLAVQAQVPIVPIVMS 211
Cdd:TIGR00530  80 KAAIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 98-211 1.52e-35

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 123.62  E-value: 1.52e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175     98 YVVVSNHQSSLDLLGMMEVLP---GRCVPIAKRELLWAGSAGLACWLAGVIFIDRKRTGDAISVMSEVAQtLLTQDVRVW 174
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPrklGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVE-LLKEGEWLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 15100175    175 VFPEGTRNHNGSMLPFKRGAFHLAVQAQVPIVPIVMS 211
Cdd:smart00563  80 IFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIR 116
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 34-258 1.22e-28

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 109.72  E-value: 1.22e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175   34 YFFKMAFYNGWILFLAVLAIPVCAVRGRNVENMKILRLMLLHIKYLYGIRVEVRGAHHFPPSQPYVVVSNHQSSLDLLGM 113
Cdd:PRK15018   3 YIFRLIITVIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMVTA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175  114 MEVLPGRCVPIAKRELLWAGSAGLACWLAGVIFIDRKRTGDAISVMSEVAQTLLTQDVRVWVFPEGTRNHNGSMLPFKRG 193
Cdd:PRK15018  83 SNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFKTG 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15100175  194 AFHLAVQAQVPIVPIVMSSYQDFYckKERRFTSGQCQVRVLPPVPTEGLTPDDVPALADRVRHSM 258
Cdd:PRK15018 163 AFHAAIAAGVPIIPVCVSTTSNKI--NLNRLHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIM 225
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 81-211 1.18e-18

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 81.31  E-value: 1.18e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175  81 GIRVEVRGAHHFPPSQPYVVVSNHQSSLDLLGMM---EVLPGRCVPIAKRELLwagsaGLACWL---AGVIFIDRKRTGD 154
Cdd:cd06551  11 FVRLEVKGPPPPPGGGPVLFVSNHSSWWDGLILFlllERGLRRDVYGLMDEEL-----LERYPFftrLGAFSVDRDSPRS 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15100175 155 AISVMSEVAQTLLTQDVRVWVFPEGTRNHNGS-MLPFKRGAFHLAVQAQVPIVPIVMS 211
Cdd:cd06551  86 AAKSLKYVARLLSKPGSVVWIFPEGTRTRRDKrPLQFKPGVAHLAEKAGVPIVPVALR 143
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 83-255 1.64e-18

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 81.70  E-value: 1.64e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175   83 RVEVRGAHHFP-PSQPYVVVSNHQSSLDLLGMMEVlpGRCVP-IAKRELLWAGSAGLACWLAGVIFIdrKRTgDAISVMS 160
Cdd:PLN02901  36 KIEVEGLENLPsPDEPAVYVSNHQSFLDIYTLFHL--GRPFKfISKTSIFLIPIIGWAMYMTGHIPL--KRM-DRRSQLE 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175  161 EVAQT--LLTQDVRVWVFPEGTRNHNGSMLPFKRGAFHLAVQAQVPIVPIV-MSSYQDFYCKKERRFTSGQCQVRVLPPV 237
Cdd:PLN02901 111 CLKRCmeLLKKGASVFFFPEGTRSKDGKLAAFKKGAFSVAAKTGVPVVPITlVGTGKIMPNGKEGILNPGSVKVVIHPPI 190

                        170
                 ....*....|....*...
gi 15100175  238 ptEGLTPDDvpaLADRVR 255
Cdd:PLN02901 191 --EGSDADE---LCNEAR 203
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 70-274 4.72e-14

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 69.17  E-value: 4.72e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175  70 RLMLlhikYLYGI-RVEVRGAHHfPPSQPYVVVSNHQSSLDLLGMMEVLPgrCVPIAKRELLWAGSAGLACWLAGVIFID 148
Cdd:cd07991   2 RVLL----FAFGFyVIKVHGKPD-PPEAPRIIVANHTSFIDPLILFSDLF--PSIVAKKELGKLPFIGTILRALGCIFVD 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175 149 RKRTGDAISVMSEVAQTLLTQDVR-VWVFPEGTRNHNGSMLPFKRGAFhlavQAQVPIVPIVM----------------S 211
Cdd:cd07991  75 RSEPKDRKKVVEEIKERATDPNWPpILIFPEGTTTNGKALIMFKKGAF----EPGVPVQPVAIrypnkfvdafwnssgyS 150

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15100175 212 SYQDFYckkeRRFTS--GQCQVRVLPPV--PTEGLTPDdvpALADRVRHSMLTVFREISTDgRGGGD 274
Cdd:cd07991 151 SLMYLF----RLLTQpaNVLEVEFLPVYtpSEEGEDPK---EFANRVRLIMANKLGLPATD-WTGED 209
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 78-181 3.90e-13

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 66.49  E-value: 3.90e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175  78 YLYGIRVEVRGAHHFPPSQPYVVVSNHQSSLD-LLGMMEVLPGRCVP----IAKRELLWAGSAGLACWLAGVIFIDRKRT 152
Cdd:cd07990   6 WLSGVKVVVYGDEPKLPKERALIISNHRSEVDwLVLWMLADRFGRLGrlkiVLKDSLKYPPLGGWGWQLGEFIFLKRKWE 85

                        90       100       110
                ....*....|....*....|....*....|.
gi 15100175 153 GDAIsVMSEVAQTLLTQDVRVWV--FPEGTR 181
Cdd:cd07990  86 KDEK-TIKRQLKRLKDSPEPFWLliFPEGTR 115
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 45-207 2.56e-09

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 58.01  E-value: 2.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175    45 ILFLAVLAIPVCAVRGRNVEN--MKILRLMLLHIKYlygiRVEVRGAHHFPPSQPYVVVSNHQSSLD--LLGMMEVLPGR 120
Cdd:PRK08633  392 FYLIALVTLIGTLYTLLLLPDslLRFLLLLLMHTRY----RLRVEGRENIPAKGGALLLGNHVSWIDwaLLQAASPRPIR 467

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175   121 CV---PIAKRELLwagsaglaCWLA---GVIFIDRKRTGDAISVMSEvaqtLLTQDVRVWVFPEGTRNHNGSMLPFKRGa 194
Cdd:PRK08633  468 FVmerSIYEKWYL--------KWFFklfGVIPISSGGSKESLEFIRK----ALDDGEVVCIFPEGAITRNGQLNEFKRG- 534

                         170
                  ....*....|....
gi 15100175   195 FHLAVQ-AQVPIVP 207
Cdd:PRK08633  535 FELIVKgTDVPIIP 548
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 83-222 2.67e-08

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 53.03  E-value: 2.67e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175  83 RVEVRGAHHFPPSQPYVVVSNHQSSL-DLLGMMEVLPGRCVPIAKRELLWAGSAGLACWLAGVIFIDRKR----TGDAIS 157
Cdd:cd07992  15 RITVVGRENVPKDGPVIFLGNHPNALiDPLLLAATLRRPVRFLAKADLFKNPLIGWLLESFGAIPVYRPKdlarGGIGKI 94

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15100175 158 ----VMSEVAQTLLTQDvRVWVFPEGTrNHNGS-MLPFKRGAFHLAVQA------QVPIVPIVMssyqdFYCKKER 222
Cdd:cd07992  95 snaaVFDAVGEALKAGG-AIGIFPEGG-SHDRPrLLPLKAGAARMALEAleagqkDVKIVPVGL-----NYEDKSR 163
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 124-255 3.73e-07

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 48.75  E-value: 3.73e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175 124 IAKRELLWAGSAGLACWLaGVIFIDRKRTGDAISVMSEVAQTlltQDVRVWVF-PEGTRNHNGsmlPFKRGAFHLAVQAQ 202
Cdd:cd07988  52 LGKHSLFKPPLGPFMRWL-GGIPVDRSRAGGLVEQVVEEFRR---REEFVLAIaPEGTRSKVD---KWKTGFYHIARGAG 124

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 15100175 203 VPIVPivmsSYQDFYCKkerrftsgqcQVRVLPPVPTEGLTPDDVPALADRVR 255
Cdd:cd07988 125 VPILL----VYLDYKRK----------TVGIGPLFEPSGDIEADLAAIRAFYR 163
PRK14014 PRK14014
putative acyltransferase; Provisional
 76-149 4.32e-07

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 50.24  E-value: 4.32e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15100175   76 IKYLYGIRVEVRGAHHFPPSQPYVVVSNHQSSLDLLGMMEVLPGRcVPI----AKRELLWAGSAGLACWLAGVIFIDR 149
Cdd:PRK14014  67 LRLLPRTQWDVEGLEGLSKKGWYLVISNHQSWVDILVLQYVFNRR-IPMlkffLKQELIWVPFLGLAWWALDFPFMKR 143
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
 142-232 7.13e-07

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 48.72  E-value: 7.13e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175 142 AGVIFIDRKRTGDAI--SVMSEVAQTLLTQDVRVWVFPEGTRNHNGSMLPFKRG-------AFHLAVQAQVPIVPIVMsS 212
Cdd:cd07993  71 LGAFFIRRSFGKDPLyrAVLQEYVQELLKNGQPLEFFIEGTRSRTGKLLPPKLGllsvvveAYLKGSVPDVLIVPVSI-S 149

                        90       100       110
                ....*....|....*....|....*....|.
gi 15100175 213 Y-----QDFYC------KKERRFTSGQCQVR 232
Cdd:cd07993 150 YdrvleEELYAeellgpPKPKESLSGLLGAS 180
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
36-257 5.49e-06

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 47.65  E-value: 5.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175    36 FKMAFYNGWI-LFLAVL----AIPVCAVRGRNVenMKILRLMLLHIKYlygiRVEVRGAHHFPPSQP-YVVVSNHQSSLD 109
Cdd:PRK06814  394 QALGFSIPWIiLFIALAnlivAILILRLLPTNL--LRDIFSILFRAFY----RVEVKGLENLQKAGKkAVIAANHVSFLD 467

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175   110 LLGMMEVLPGRCV-----PIAKRellWagsaglacWLAGVIFIDRKRTGDAISVMSevAQTL---LTQDVRVWVFPEGTR 181
Cdd:PRK06814  468 GPLLAAYLPEEPTfaidtDIAKA---W--------WVKPFLKLAKALPVDPTNPMA--TRTLikeVQKGEKLVIFPEGRI 534

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175   182 NHNGSMLPFKRGAFHLAVQAQVPIVPIVMSSYQ---------DFYCKKERRFTsgqcqVRVLPPVpteglTPDDVPALAD 252
Cdd:PRK06814  535 TVTGSLMKIYDGPGMIADKAGAMVVPVRIDGLQfthfsrlknQVRRKWFPKVT-----VTILPPV-----KLAVDPELKG 604


                  ....*
gi 15100175   253 RVRHS 257
Cdd:PRK06814  605 RERRS 609
COG3176 COG3176
Putative hemolysin [General function prediction only];
79-210 4.02e-05

Putative hemolysin [General function prediction only];


Pssm-ID: 442409  Cd Length: 270  Bit Score: 44.26  E-value: 4.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175  79 LYGIRVEV--RGAHHFPPSQPYVVVSNHQ-SSLDLLGMMEVLpGRCVPIAK---RELLWAGSAGLACwlAGVIFIDRkrt 152
Cdd:COG3176  52 ELGARLEVpeGDLDRIDADGHLLVVANHPlGILDGLALLKLV-GTVRPDYRilaNDLALRIPGGFYS--ELEFPVDP--- 125

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175 153 gDAISVMSEVAQTLLtQDVRVWVFPEGTRNHNGS--MLPFKRGAFHLAVQAQVPIVPIVM 210
Cdd:COG3176 126 -FNLETLKAARRHLL-EGGRSCVFPAGRVSGARRviDLLWSGLAAKLARKAGAPVVPVYF 183
LPLAT_ACT14924-like cd07986
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 82-208 1.60e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.


Pssm-ID: 153248 [Multi-domain]  Cd Length: 210  Bit Score: 41.85  E-value: 1.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175  82 IRVEVRGAHHFPPSQPYVVVSNHQ-SSLDLLGMMEVLpGRCVP---IAKRELLWAGSAgLACWLAGVIFIDRKRTGD-AI 156
Cdd:cd07986   8 LEVDVSGLENIPKDGPVVIVANHPfGILDGLILADLL-GSVRPdvrILANQLLSKIPE-LRDLFIPVDPLEGRAALAkNR 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15100175 157 SVMSEvAQTLLTQDVRVWVFPEGT-----RNHNGSM-LPFKRGAFHLAVQAQVPIVPI 208
Cdd:cd07986  86 ESLRE-ALRHLKNGGALIIFPAGRvstasPPFGRVSdRPWNPFVARLARKAKAPVVPV 142
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 85-207 3.30e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 38.04  E-value: 3.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15100175  85 EVRGAHHFPPSQPYVVVSNHQ---SSLDLLGMMEVL--PGRcVPIAKRELLWAGSAGLACWLAgvifidrkRTGdAISVM 159
Cdd:cd07987   9 EVRGLENIPDEGPALLVHPHGglpIDGALLAAAFLLlfPGR-LPRALADHFLFPLPGLRDLLR--------RLG-AVPGS 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15100175 160 SEVAQTLLTQDVRVWVFPEGTR-------NHNGSMLPFKRGAFHLAVQAQVPIVP 207
Cdd:cd07987  79 RENCVRLLREGELVLIFPGGARealkskrEEYYLLWKKRKGFARLALRAGAPIVP 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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