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Conserved domains on  [gi|602617433|ref|NP_116271|]
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paraneoplastic antigen-like protein 6A [Homo sapiens]

Protein Classification

PNMA domain-containing protein( domain architecture ID 10632857)

PNMA domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PNMA pfam14893
PNMA; The PNMA family includes paraneoplastic antigens Ma 1, 2 and 3, found in the serum of ...
1-319 2.13e-140

PNMA; The PNMA family includes paraneoplastic antigens Ma 1, 2 and 3, found in the serum of patients with paraneoplastic neurological disorders. The family also includes modulator of apoptosis 1, which has a role in death receptor-dependent apoptosis.


:

Pssm-ID: 464357  Cd Length: 326  Bit Score: 402.87  E-value: 2.13e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602617433    1 MAVTMLQDWCRWMGVNARRGLLILGIPEDCDDAEFQESLEAALRPMGHFTVLGKAFREEDNATAALVELDREVNYALVPR 80
Cdd:pfam14893   1 MALTLLEDWCRGMGVDIHRALLVLGIPEDCGEAEIEETLQAALAPLGRYRVLGRMFRREENAKAALVELAEGVNYALIPR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602617433   81 EIPGTGGPWNVVFVPRCSGEEFLGlgRVFHFPEQEGQMVESVAGALGVGLRRV---------CWLRSIGQAVQPWVEAVR 151
Cdd:pfam14893  81 EIPGKGGVWRVVCKPPTQDAEFLK--RLNEFLDAEGRTVEDVARLLGLNNPPPnqppeswaeALGQLLGAALQPLLESMA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602617433  152 CQSLGVFSGRDQPAPGEESFEVWLDHTTEMLHVWQGVSERERRRRLLEGLRGTALQLVHALLAENPARTAQDCLAALAQV 231
Cdd:pfam14893 159 YRKLRVFSGREIPGPGEESFESWLEHATEMLEAWQHVSEAEKRRRLVESLRGPALEVISALKAENPDITVEDCLKALVQV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602617433  232 FGDNESQATIRVKCLTAQQQSGERLSAFVLRLEVLLQKAMEKEALARASADRVRLRQMLTRAHLTEPLDEALRKLRMAGR 311
Cdd:pfam14893 239 FGAKESSRTAQLKFLTTYQKPGEKLSAYVLRLEPLLQKAVEKGALSAASADQARLEQVLAGARESPTLRKKLRLLSAKGR 318

                  ....*...
gi 602617433  312 SPSFLEML 319
Cdd:pfam14893 319 PPGFLELL 326
 
Name Accession Description Interval E-value
PNMA pfam14893
PNMA; The PNMA family includes paraneoplastic antigens Ma 1, 2 and 3, found in the serum of ...
1-319 2.13e-140

PNMA; The PNMA family includes paraneoplastic antigens Ma 1, 2 and 3, found in the serum of patients with paraneoplastic neurological disorders. The family also includes modulator of apoptosis 1, which has a role in death receptor-dependent apoptosis.


Pssm-ID: 464357  Cd Length: 326  Bit Score: 402.87  E-value: 2.13e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602617433    1 MAVTMLQDWCRWMGVNARRGLLILGIPEDCDDAEFQESLEAALRPMGHFTVLGKAFREEDNATAALVELDREVNYALVPR 80
Cdd:pfam14893   1 MALTLLEDWCRGMGVDIHRALLVLGIPEDCGEAEIEETLQAALAPLGRYRVLGRMFRREENAKAALVELAEGVNYALIPR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602617433   81 EIPGTGGPWNVVFVPRCSGEEFLGlgRVFHFPEQEGQMVESVAGALGVGLRRV---------CWLRSIGQAVQPWVEAVR 151
Cdd:pfam14893  81 EIPGKGGVWRVVCKPPTQDAEFLK--RLNEFLDAEGRTVEDVARLLGLNNPPPnqppeswaeALGQLLGAALQPLLESMA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602617433  152 CQSLGVFSGRDQPAPGEESFEVWLDHTTEMLHVWQGVSERERRRRLLEGLRGTALQLVHALLAENPARTAQDCLAALAQV 231
Cdd:pfam14893 159 YRKLRVFSGREIPGPGEESFESWLEHATEMLEAWQHVSEAEKRRRLVESLRGPALEVISALKAENPDITVEDCLKALVQV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602617433  232 FGDNESQATIRVKCLTAQQQSGERLSAFVLRLEVLLQKAMEKEALARASADRVRLRQMLTRAHLTEPLDEALRKLRMAGR 311
Cdd:pfam14893 239 FGAKESSRTAQLKFLTTYQKPGEKLSAYVLRLEPLLQKAVEKGALSAASADQARLEQVLAGARESPTLRKKLRLLSAKGR 318

                  ....*...
gi 602617433  312 SPSFLEML 319
Cdd:pfam14893 319 PPGFLELL 326
 
Name Accession Description Interval E-value
PNMA pfam14893
PNMA; The PNMA family includes paraneoplastic antigens Ma 1, 2 and 3, found in the serum of ...
1-319 2.13e-140

PNMA; The PNMA family includes paraneoplastic antigens Ma 1, 2 and 3, found in the serum of patients with paraneoplastic neurological disorders. The family also includes modulator of apoptosis 1, which has a role in death receptor-dependent apoptosis.


Pssm-ID: 464357  Cd Length: 326  Bit Score: 402.87  E-value: 2.13e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602617433    1 MAVTMLQDWCRWMGVNARRGLLILGIPEDCDDAEFQESLEAALRPMGHFTVLGKAFREEDNATAALVELDREVNYALVPR 80
Cdd:pfam14893   1 MALTLLEDWCRGMGVDIHRALLVLGIPEDCGEAEIEETLQAALAPLGRYRVLGRMFRREENAKAALVELAEGVNYALIPR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602617433   81 EIPGTGGPWNVVFVPRCSGEEFLGlgRVFHFPEQEGQMVESVAGALGVGLRRV---------CWLRSIGQAVQPWVEAVR 151
Cdd:pfam14893  81 EIPGKGGVWRVVCKPPTQDAEFLK--RLNEFLDAEGRTVEDVARLLGLNNPPPnqppeswaeALGQLLGAALQPLLESMA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602617433  152 CQSLGVFSGRDQPAPGEESFEVWLDHTTEMLHVWQGVSERERRRRLLEGLRGTALQLVHALLAENPARTAQDCLAALAQV 231
Cdd:pfam14893 159 YRKLRVFSGREIPGPGEESFESWLEHATEMLEAWQHVSEAEKRRRLVESLRGPALEVISALKAENPDITVEDCLKALVQV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602617433  232 FGDNESQATIRVKCLTAQQQSGERLSAFVLRLEVLLQKAMEKEALARASADRVRLRQMLTRAHLTEPLDEALRKLRMAGR 311
Cdd:pfam14893 239 FGAKESSRTAQLKFLTTYQKPGEKLSAYVLRLEPLLQKAVEKGALSAASADQARLEQVLAGARESPTLRKKLRLLSAKGR 318

                  ....*...
gi 602617433  312 SPSFLEML 319
Cdd:pfam14893 319 PPGFLELL 326
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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