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Conserved domains on  [gi|14249718|ref|NP_116315|]
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transcription elongation factor A protein-like 3 [Homo sapiens]

Protein Classification

BEX domain-containing protein( domain architecture ID 10517751)

BEX domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BEX pfam04538
Brain expressed X-linked like family; This is a family of transcription elongation factors ...
 81-175 3.10e-21

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.


:

Pssm-ID: 461346 [Multi-domain]  Cd Length: 103  Bit Score: 83.85  E-value: 3.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249718    81 EGKPASQAKPESQPraaEKRPAEDYVPRKAKRKTDRG-TDDSPKDSQEDLQERHLSSEEMMRECGDVSRAQEELRK-KQK 158
Cdd:pfam04538   9 EGKPEEQGKVENEE---EPEDLEGGEPRKPRGNTRRGrVRQSVPNFREDIPNRHLSPEEMMREGDDMERFGEEMRElRQK 85

                          90
                  ....*....|....*..
gi 14249718   159 MGGFHWMQRDVQDPFAP 175
Cdd:pfam04538  86 LREQQWRQRPHRDHHYP 102
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 2-104 1.19e-07

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 51.15  E-value: 1.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249718      2 EKPYNKNEGNLENEGKPEDEVEPDDEGKSDEEEKPDVEGKTECEGKREDEGEPGD-EGQLEDEGSQ-EKQGRSEGEGKPQ 79
Cdd:TIGR00927  675 TKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEgEIETGEEGEEvEDEGEGEAEGKHE 754

                           90       100
                   ....*....|....*....|....*
gi 14249718     80 GEGKPASQAKPESQPRAAEKRPAED 104
Cdd:TIGR00927  755 VETEGDRKETEHEGETEAEGKEDED 779
 
Name Accession Description Interval E-value
BEX pfam04538
Brain expressed X-linked like family; This is a family of transcription elongation factors ...
 81-175 3.10e-21

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.


Pssm-ID: 461346 [Multi-domain]  Cd Length: 103  Bit Score: 83.85  E-value: 3.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249718    81 EGKPASQAKPESQPraaEKRPAEDYVPRKAKRKTDRG-TDDSPKDSQEDLQERHLSSEEMMRECGDVSRAQEELRK-KQK 158
Cdd:pfam04538   9 EGKPEEQGKVENEE---EPEDLEGGEPRKPRGNTRRGrVRQSVPNFREDIPNRHLSPEEMMREGDDMERFGEEMRElRQK 85

                          90
                  ....*....|....*..
gi 14249718   159 MGGFHWMQRDVQDPFAP 175
Cdd:pfam04538  86 LREQQWRQRPHRDHHYP 102
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 2-104 1.19e-07

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 51.15  E-value: 1.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249718      2 EKPYNKNEGNLENEGKPEDEVEPDDEGKSDEEEKPDVEGKTECEGKREDEGEPGD-EGQLEDEGSQ-EKQGRSEGEGKPQ 79
Cdd:TIGR00927  675 TKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEgEIETGEEGEEvEDEGEGEAEGKHE 754

                           90       100
                   ....*....|....*....|....*
gi 14249718     80 GEGKPASQAKPESQPRAAEKRPAED 104
Cdd:TIGR00927  755 VETEGDRKETEHEGETEAEGKEDED 779
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 26-145 4.00e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 37.67  E-value: 4.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249718     26 DEGKSDEEEKPDVEGKTECEGKRED--EGEPGDE--GQLEDEGSQEKQGRSEGEGKPQGEGKPASQAKPESQPRAAEKRP 101
Cdd:TIGR00927  629 DLSKGDVAEAEHTGERTGEEGERPTeaEGENGEEsgGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKG 708

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 14249718    102 AEDYVPRKAKRKT-DRGTDDspkdsqedlqERHLSSEEMMRECGD 145
Cdd:TIGR00927  709 ETEAEEVEHEGETeAEGTED----------EGEIETGEEGEEVED 743
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 15-101 4.91e-03

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 37.08  E-value: 4.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249718  15 EGKPEDEVEPDDEGKSDEEEKPDVEGKTECEGKREDEGEPGDEGqlEDEGSQEKQGRSEGEGKPQGEGKPASQAKPESQP 94
Cdd:COG4547 209 EELGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEGAEAEDA--EASGDDAEEGESEAAEAESDEMAEEAEGEDSEEP 286


                ....*..
gi 14249718  95 rAAEKRP 101
Cdd:COG4547 287 -GEPWRP 292
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 13-112 5.99e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 36.88  E-value: 5.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249718   13 ENEGKPEDEVEPDDEGKSDEE---EKPDvEGKTECEGKREDEGEPGDEGQLEDEGSQ-EKQGRSEGEGKPQGEGKPASqA 88
Cdd:PRK13108 358 ESTPAVEETSEADIEREQPGDlagQAPA-AHQVDAEAASAAPEEPAALASEAHDETEpEVPEKAAPIPDPAKPDELAV-A 435

                         90       100
                 ....*....|....*....|....
gi 14249718   89 KPESQPRAAEKRPAEDYVPRKAKR 112
Cdd:PRK13108 436 GPGDDPAEPDGIRRQDDFSSRRRR 459
 
Name Accession Description Interval E-value
BEX pfam04538
Brain expressed X-linked like family; This is a family of transcription elongation factors ...
 81-175 3.10e-21

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.


Pssm-ID: 461346 [Multi-domain]  Cd Length: 103  Bit Score: 83.85  E-value: 3.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249718    81 EGKPASQAKPESQPraaEKRPAEDYVPRKAKRKTDRG-TDDSPKDSQEDLQERHLSSEEMMRECGDVSRAQEELRK-KQK 158
Cdd:pfam04538   9 EGKPEEQGKVENEE---EPEDLEGGEPRKPRGNTRRGrVRQSVPNFREDIPNRHLSPEEMMREGDDMERFGEEMRElRQK 85

                          90
                  ....*....|....*..
gi 14249718   159 MGGFHWMQRDVQDPFAP 175
Cdd:pfam04538  86 LREQQWRQRPHRDHHYP 102
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 2-104 1.19e-07

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 51.15  E-value: 1.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249718      2 EKPYNKNEGNLENEGKPEDEVEPDDEGKSDEEEKPDVEGKTECEGKREDEGEPGD-EGQLEDEGSQ-EKQGRSEGEGKPQ 79
Cdd:TIGR00927  675 TKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEgEIETGEEGEEvEDEGEGEAEGKHE 754

                           90       100
                   ....*....|....*....|....*
gi 14249718     80 GEGKPASQAKPESQPRAAEKRPAED 104
Cdd:TIGR00927  755 VETEGDRKETEHEGETEAEGKEDED 779
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 7-145 4.28e-07

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 49.61  E-value: 4.28e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249718      7 KNEGNLENEGKPEDEVEPDDEGKSDEEEKPDVEGKTECEGKREDEGEPGDEGQLEDEGSQEKQG-RSEGEGKPQGEGKPA 85
Cdd:TIGR00927  662 ESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGtEDEGEIETGEEGEEV 741

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249718     86 SQakpESQPRAAEKRPAEdyvpRKAKRKTDRGTDDSPKDSQEDLQERHLSSEEMMRECGD 145
Cdd:TIGR00927  742 ED---EGEGEAEGKHEVE----TEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGD 794
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 8-152 1.52e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 38.82  E-value: 1.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249718      8 NEGNLENEGKPEDEVEPDDE------GKSDEEEKPDVEGKTECEGKREDEGEPGDEGQLEDEGSQEKQGRSEGEGKpQGE 81
Cdd:TIGR00927  743 DEGEGEAEGKHEVETEGDRKetehegETEAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQ-SET 821

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14249718     82 GKPASQAKPESQPRAAEkrpAEDYVPRKAKRKTDRGTDDSPKDSQEDLQERHLSSEEMMRECGDVSRAQEE 152
Cdd:TIGR00927  822 QADDTEVKDETGEQELN---AENQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEEEE 889
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 9-97 2.70e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 38.05  E-value: 2.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249718      9 EGNLENEGKPEDEVEPDDEGKSDEEEKPDVEGKTECEGKREDEGEPG----------DEGQLEDEGSQEKQGRSEGEGKP 78
Cdd:TIGR00927  808 EAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDEKGVDGgggsdggdseEEEEEEEEEEEEEEEEEEEEEEE 887

                           90
                   ....*....|....*....
gi 14249718     79 QGEGKPASQAKPESQPRAA 97
Cdd:TIGR00927  888 EENEEPLSLEWPETRQKQA 906
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 26-145 4.00e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 37.67  E-value: 4.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249718     26 DEGKSDEEEKPDVEGKTECEGKRED--EGEPGDE--GQLEDEGSQEKQGRSEGEGKPQGEGKPASQAKPESQPRAAEKRP 101
Cdd:TIGR00927  629 DLSKGDVAEAEHTGERTGEEGERPTeaEGENGEEsgGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKG 708

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 14249718    102 AEDYVPRKAKRKT-DRGTDDspkdsqedlqERHLSSEEMMRECGD 145
Cdd:TIGR00927  709 ETEAEEVEHEGETeAEGTED----------EGEIETGEEGEEVED 743
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 15-101 4.91e-03

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 37.08  E-value: 4.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249718  15 EGKPEDEVEPDDEGKSDEEEKPDVEGKTECEGKREDEGEPGDEGqlEDEGSQEKQGRSEGEGKPQGEGKPASQAKPESQP 94
Cdd:COG4547 209 EELGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEGAEAEDA--EASGDDAEEGESEAAEAESDEMAEEAEGEDSEEP 286


                ....*..
gi 14249718  95 rAAEKRP 101
Cdd:COG4547 287 -GEPWRP 292
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 13-112 5.99e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 36.88  E-value: 5.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249718   13 ENEGKPEDEVEPDDEGKSDEE---EKPDvEGKTECEGKREDEGEPGDEGQLEDEGSQ-EKQGRSEGEGKPQGEGKPASqA 88
Cdd:PRK13108 358 ESTPAVEETSEADIEREQPGDlagQAPA-AHQVDAEAASAAPEEPAALASEAHDETEpEVPEKAAPIPDPAKPDELAV-A 435

                         90       100
                 ....*....|....*....|....
gi 14249718   89 KPESQPRAAEKRPAEDYVPRKAKR 112
Cdd:PRK13108 436 GPGDDPAEPDGIRRQDDFSSRRRR 459
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 14-152 9.78e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 36.51  E-value: 9.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249718     14 NEGKPEDEVE-PDDEGKSDEEEKPdveGKTECEGKREDEGE-PGD-EGQLEDEGSQEKQGRSEGEGKPQGEGKPASQAKP 90
Cdd:TIGR00927  647 EEGERPTEAEgENGEESGGEAEQE---GETETKGENESEGEiPAErKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEA 723

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14249718     91 ESQPRAAEKRPAEDyvprkAKRKTDRGTDDSPKDSQEDLQERHLSSEEMMRECGDVSRAQEE 152
Cdd:TIGR00927  724 EGTEDEGEIETGEE-----GEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDE 780
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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