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Conserved domains on  [gi|109150412|ref|NP_116322|]
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UDP-N-acetylglucosamine transporter TMEM241 isoform 1 [Homo sapiens]

Protein Classification

DMT family protein( domain architecture ID 708199)

DMT (drug/metabolite transporter) family protein similar to nucleotide-sugar transporters, that found in the Golgi apparatus and the endoplasmic reticulum of eukaryotic cells, such as GDP-mannose transporter, and to triose-phosphate transporters such as Homo sapiens SLC35D

Gene Ontology:  GO:0005338|GO:0008643
TCDB:  2.A.7

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
VRG4 super family cl26746
Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational ...
10-193 5.37e-07

Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5070:

Pssm-ID: 227402  Cd Length: 309  Bit Score: 50.27  E-value: 5.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109150412  10 LTFCTCYLASYLTNKYVLSVLKFTYPTLFQGWQTLIGGLLLHVSWKLGWVEINSSSRSHvlvWLPASVLFVGIIYAGSRA 89
Cdd:COG5070   12 LSYCFSSILMTLTNKYVLSNLGFNMNFLLLAVQSLVCVVGLLILKFLRLVEFRLTKAKK---WFPISFLLVVMIYTSSKS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109150412  90 LSRLAIPVFLTLHNVAEVIIC-GYQKCFQKEKTSPA-------KICSALLLLAAAGCLPFNDSQFNPdGYFWAIIHLLCV 161
Cdd:COG5070   89 LQYLAVPIYTIFKNLTIILIAyGEVLFFGGRVTSLEllsfilmVLSSVVATWGDQQASAFKAQILNP-GYLWMFTNCLSS 167
                        170       180       190
                 ....*....|....*....|....*....|...
gi 109150412 162 GAYK-ILQKSQKPSALSDIDQQYLNYIFSVVLL 193
Cdd:COG5070  168 AAFVlIMRKRIKLTNFKDFDTMFYNNLLSLPIL 200
 
Name Accession Description Interval E-value
VRG4 COG5070
Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational ...
10-193 5.37e-07

Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion];


Pssm-ID: 227402  Cd Length: 309  Bit Score: 50.27  E-value: 5.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109150412  10 LTFCTCYLASYLTNKYVLSVLKFTYPTLFQGWQTLIGGLLLHVSWKLGWVEINSSSRSHvlvWLPASVLFVGIIYAGSRA 89
Cdd:COG5070   12 LSYCFSSILMTLTNKYVLSNLGFNMNFLLLAVQSLVCVVGLLILKFLRLVEFRLTKAKK---WFPISFLLVVMIYTSSKS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109150412  90 LSRLAIPVFLTLHNVAEVIIC-GYQKCFQKEKTSPA-------KICSALLLLAAAGCLPFNDSQFNPdGYFWAIIHLLCV 161
Cdd:COG5070   89 LQYLAVPIYTIFKNLTIILIAyGEVLFFGGRVTSLEllsfilmVLSSVVATWGDQQASAFKAQILNP-GYLWMFTNCLSS 167
                        170       180       190
                 ....*....|....*....|....*....|...
gi 109150412 162 GAYK-ILQKSQKPSALSDIDQQYLNYIFSVVLL 193
Cdd:COG5070  168 AAFVlIMRKRIKLTNFKDFDTMFYNNLLSLPIL 200
 
Name Accession Description Interval E-value
VRG4 COG5070
Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational ...
10-193 5.37e-07

Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion];


Pssm-ID: 227402  Cd Length: 309  Bit Score: 50.27  E-value: 5.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109150412  10 LTFCTCYLASYLTNKYVLSVLKFTYPTLFQGWQTLIGGLLLHVSWKLGWVEINSSSRSHvlvWLPASVLFVGIIYAGSRA 89
Cdd:COG5070   12 LSYCFSSILMTLTNKYVLSNLGFNMNFLLLAVQSLVCVVGLLILKFLRLVEFRLTKAKK---WFPISFLLVVMIYTSSKS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109150412  90 LSRLAIPVFLTLHNVAEVIIC-GYQKCFQKEKTSPA-------KICSALLLLAAAGCLPFNDSQFNPdGYFWAIIHLLCV 161
Cdd:COG5070   89 LQYLAVPIYTIFKNLTIILIAyGEVLFFGGRVTSLEllsfilmVLSSVVATWGDQQASAFKAQILNP-GYLWMFTNCLSS 167
                        170       180       190
                 ....*....|....*....|....*....|...
gi 109150412 162 GAYK-ILQKSQKPSALSDIDQQYLNYIFSVVLL 193
Cdd:COG5070  168 AAFVlIMRKRIKLTNFKDFDTMFYNNLLSLPIL 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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