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Conserved domains on  [gi|14602433|ref|NP_116569|]
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carbohydrate-responsive element-binding protein isoform alpha [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NES2-NLS_ChREBP cd21771
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 81-196 3.28e-86

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), and similar proteins; ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a large transcription factor that functions at two levels, nuclear localization and DNA binding. It binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. ChREBP contains functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


:

Pssm-ID: 439287  Cd Length: 116  Bit Score: 269.53  E-value: 3.28e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433  81 SIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKP 160
Cdd:cd21771   1 SIDPTLTRLFECMSLAYSGKLVSPKWKNFKGLRLLWRDKIRLNNAIWRAWYIQYVEKRKNPVCGFVTPLEGSEADEHRKP 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 14602433 161 EAVVLEGNYWKRRIEVVMREYHKWRIYYKKRLRKPS 196
Cdd:cd21771  81 EAVVLEGNYWKRRIEVVMKEYHKWRIYYKKRLRKSS 116
bHLHzip_MLXIPL cd19689
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) ...
 646-721 2.14e-47

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) and similar proteins; MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


:

Pssm-ID: 381532  Cd Length: 76  Bit Score: 162.83  E-value: 2.14e-47
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14602433 646 KTENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDEI 721
Cdd:cd19689   1 KTETRRITHISAEQKRRFNIKLGFDTLHSLVTTLSSQPSIKISKATTLQKTAEYISKLQQERAQLQEEAQRLRDQI 76
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 306-633 5.39e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 5.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433   306 SRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRL-----QARNSCPGPLDSSAFLSSdfllPE 380
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLppgpaAARQASPALPAAPAPPAV----PA 2746

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433   381 DPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPA---------PGVSPLPA 451
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAavlapaaalPPAASPAG 2826

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433   452 PAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQ- 530
Cdd:PHA03247 2827 PLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPe 2906

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433   531 -LLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSP------ 603
Cdd:PHA03247 2907 rPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPqpapsr 2986

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 14602433   604 --PAPSGSERR-------------LSGDLSSMPGPGTLSVRVSPP 633
Cdd:PHA03247 2987 eaPASSTPPLTghslsrvsswassLALHEETDPPPVSLKQTLWPP 3031
 
Name Accession Description Interval E-value
NES2-NLS_ChREBP cd21771
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 81-196 3.28e-86

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), and similar proteins; ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a large transcription factor that functions at two levels, nuclear localization and DNA binding. It binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. ChREBP contains functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439287  Cd Length: 116  Bit Score: 269.53  E-value: 3.28e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433  81 SIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKP 160
Cdd:cd21771   1 SIDPTLTRLFECMSLAYSGKLVSPKWKNFKGLRLLWRDKIRLNNAIWRAWYIQYVEKRKNPVCGFVTPLEGSEADEHRKP 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 14602433 161 EAVVLEGNYWKRRIEVVMREYHKWRIYYKKRLRKPS 196
Cdd:cd21771  81 EAVVLEGNYWKRRIEVVMKEYHKWRIYYKKRLRKSS 116
bHLHzip_MLXIPL cd19689
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) ...
 646-721 2.14e-47

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) and similar proteins; MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


Pssm-ID: 381532  Cd Length: 76  Bit Score: 162.83  E-value: 2.14e-47
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14602433 646 KTENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDEI 721
Cdd:cd19689   1 KTETRRITHISAEQKRRFNIKLGFDTLHSLVTTLSSQPSIKISKATTLQKTAEYISKLQQERAQLQEEAQRLRDQI 76
HLH pfam00010
Helix-loop-helix DNA-binding domain;
650-704 1.05e-12

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 63.25  E-value: 1.05e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 14602433   650 RRITHISAEQKRRFNIKLGFDTLHGLVSTLsaQPSLKVSKATTLQKTAEYILMLQ 704
Cdd:pfam00010   1 RREAHNERERRRRDRINDAFDELRELLPTL--PPDKKLSKAEILRLAIEYIKHLQ 53
HLH smart00353
helix loop helix domain;
657-706 4.06e-09

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 52.99  E-value: 4.06e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 14602433    657 AEQKRRFNIKLGFDTLHGLVSTLsaQPSLKVSKATTLQKTAEYILMLQQE 706
Cdd:smart00353   3 RERRRRRKINEAFDELRSLLPTL--PKNKKLSKAEILRLAIEYIKSLQEE 50
PHA03247 PHA03247
large tegument protein UL36; Provisional
 306-633 5.39e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 5.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433   306 SRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRL-----QARNSCPGPLDSSAFLSSdfllPE 380
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLppgpaAARQASPALPAAPAPPAV----PA 2746

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433   381 DPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPA---------PGVSPLPA 451
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAavlapaaalPPAASPAG 2826

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433   452 PAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQ- 530
Cdd:PHA03247 2827 PLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPe 2906

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433   531 -LLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSP------ 603
Cdd:PHA03247 2907 rPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPqpapsr 2986

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 14602433   604 --PAPSGSERR-------------LSGDLSSMPGPGTLSVRVSPP 633
Cdd:PHA03247 2987 eaPASSTPPLTghslsrvsswassLALHEETDPPPVSLKQTLWPP 3031
 
Name Accession Description Interval E-value
NES2-NLS_ChREBP cd21771
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 81-196 3.28e-86

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), and similar proteins; ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a large transcription factor that functions at two levels, nuclear localization and DNA binding. It binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. ChREBP contains functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439287  Cd Length: 116  Bit Score: 269.53  E-value: 3.28e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433  81 SIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKP 160
Cdd:cd21771   1 SIDPTLTRLFECMSLAYSGKLVSPKWKNFKGLRLLWRDKIRLNNAIWRAWYIQYVEKRKNPVCGFVTPLEGSEADEHRKP 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 14602433 161 EAVVLEGNYWKRRIEVVMREYHKWRIYYKKRLRKPS 196
Cdd:cd21771  81 EAVVLEGNYWKRRIEVVMKEYHKWRIYYKKRLRKSS 116
NES2-NLS_MLXIP cd21772
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 81-194 1.37e-67

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in MLX-interacting protein (MLXIP), and similar proteins; MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. It binds DNA by forming a heterodimer with Max-like protein (MLX) and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. MLXIP may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439288  Cd Length: 117  Bit Score: 219.93  E-value: 1.37e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433  81 SIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGP-EADAHRK 159
Cdd:cd21772   1 SIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSvDVDEHRR 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 14602433 160 PEAVVLEGNYWKRRIEVVMREYHKWRIYYKKRLRK 194
Cdd:cd21772  81 PEAIATEGKYWKRRIEIVIREYHKWRTYFKKRLQK 115
NES2-NLS_ChREBP-like cd21739
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 81-196 9.71e-67

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), MLX-interacting protein (MLXIP), and similar proteins; This family includes two transcription factors: ChREBP and MLXIP. ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), functions at two levels; nuclear localization and DNA binding. ChREBP binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. MLXIP binds DNA by forming a heterodimer with Max-like protein (MLX), and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. Members in this family may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439286  Cd Length: 113  Bit Score: 217.52  E-value: 9.71e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433  81 SIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVKRRKSPVCGFVTPLqgpEADAHRKP 160
Cdd:cd21739   1 AIDESLTKLFKCLTLAYSGKLTSPKWKNFKGLKLRWKDKIRLNNAIWREWHMQFVKKKKPPVCQFAVPL---DDDTHKKP 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 14602433 161 EAVVLEGNYWKRRIEVVMREYHKWRIYYKKRLRKPS 196
Cdd:cd21739  78 EAVVLEGKYWKRRLETVVREYKKWRLFYKDKLAGKT 113
bHLHzip_MLXIPL cd19689
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) ...
 646-721 2.14e-47

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) and similar proteins; MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


Pssm-ID: 381532  Cd Length: 76  Bit Score: 162.83  E-value: 2.14e-47
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14602433 646 KTENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDEI 721
Cdd:cd19689   1 KTETRRITHISAEQKRRFNIKLGFDTLHSLVTTLSSQPSIKISKATTLQKTAEYISKLQQERAQLQEEAQRLRDQI 76
bHLHzip_MLXIP_like cd11405
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), ...
 648-721 3.40e-37

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), MLX-interacting protein-like (MLXIPL) and similar proteins; The family includes MLXIP and MLXIPL. MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm. MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


Pssm-ID: 381411 [Multi-domain]  Cd Length: 74  Bit Score: 133.55  E-value: 3.40e-37
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 14602433 648 ENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDEI 721
Cdd:cd11405   1 EQRRLSHISAEQKRRFNIKSGFDTLQSLIPSLGQNPNQKVSKAAMLQKAAEYIKSLKRERQQMQEEAEQLRQEI 74
bHLHzip_MLXIP cd19688
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and ...
 648-721 1.18e-30

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and similar proteins; MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm.


Pssm-ID: 381531  Cd Length: 72  Bit Score: 115.04  E-value: 1.18e-30
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 14602433 648 ENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSlkVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDEI 721
Cdd:cd19688   1 KNRRMKHISAEQKRRFNIKICFDTLNSLVSTLKNSKP--ISNAITLQKTVEYIAKLQQERTQMQEETKRLREEI 72
bHLHzip_Mlx cd19687
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar ...
 649-721 1.35e-17

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar proteins; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription.


Pssm-ID: 381530 [Multi-domain]  Cd Length: 76  Bit Score: 77.85  E-value: 1.35e-17
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14602433 649 NRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQP---SLKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDEI 721
Cdd:cd19687   1 RRREAHTQAEQKRRDAIKKGYDDLQDIVPTCQQQDdigSQKLSKATILQRSIDYIQFLHQQKKKQEEELSALRKEV 76
HLH pfam00010
Helix-loop-helix DNA-binding domain;
650-704 1.05e-12

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 63.25  E-value: 1.05e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 14602433   650 RRITHISAEQKRRFNIKLGFDTLHGLVSTLsaQPSLKVSKATTLQKTAEYILMLQ 704
Cdd:pfam00010   1 RREAHNERERRRRDRINDAFDELRELLPTL--PPDKKLSKAEILRLAIEYIKHLQ 53
bHLHzip_Mlx_like cd11404
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, ...
 650-728 1.83e-12

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription. The family also includes Saccharomyces cerevisiae INO4, which is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast.


Pssm-ID: 381410 [Multi-domain]  Cd Length: 70  Bit Score: 63.09  E-value: 1.83e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14602433 650 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQpslKVSKATTLQKTAEYIlmlqQEragLQEEAQQLRDEIEELNAAI 728
Cdd:cd11404   2 RRLNHVRSEKKRRELIKKGYDELCALVPGLDPQ---KRTKADILQKAADWI----QE---LKEENEKLEEQLDELKEAA 70
bHLHzip_Myc cd11400
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a ...
 650-726 6.18e-12

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).


Pssm-ID: 381406 [Multi-domain]  Cd Length: 80  Bit Score: 61.79  E-value: 6.18e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 14602433 650 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPslKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDEIEELNA 726
Cdd:cd11400   1 KRRLHNVLERQRRNDLKNSFEKLRDLVPELADNE--KASKVVILKKATEYIKQLQQEEKKLEKEKDKLKARNEQLRK 75
bHLHzip_SREBP_like cd11395
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
 648-721 2.06e-11

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family and similar proteins; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box. The family also includes Saccharomyces cerevisiae transcription factor HMS1 (also termed high-copy MEP suppressor protein 1) and serine-rich protein TYE7. HMS1 is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation. TYE7, also termed basic-helix-loop-helix protein SGC1, is a putative bHLHzip transcription activator required for Ty1-mediated glycolytic gene expression. TYE7 N-terminal is extremely rich in serine residues. It binds DNA on E-box motifs, 5'-CANNTG-3'. TYE7 is not essential for growth.


Pssm-ID: 381401 [Multi-domain]  Cd Length: 87  Bit Score: 60.81  E-value: 2.06e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433 648 ENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQ-------------PSLKVSKATTLQKTAEYILMLQQERAGLQEEA 714
Cdd:cd11395   1 PRKRLPHNAIEKRYRSNLNTKIERLRDAIPSLRSPegksddgglgglaPTTKLSKATILTKAIEYIRHLEQENERLEEEN 80


                ....*..
gi 14602433 715 QQLRDEI 721
Cdd:cd11395  81 EELRQQV 87
bHLH_SF cd00083
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
 658-705 5.00e-11

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


Pssm-ID: 381392 [Multi-domain]  Cd Length: 46  Bit Score: 58.30  E-value: 5.00e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 14602433 658 EQKRRFNIKLGFDTLHGLVSTLSAQPslKVSKATTLQKTAEYILMLQQ 705
Cdd:cd00083   1 ERRRRDKINDAFEELKRLLPELPDSK--KLSKASILQKAVEYIRELQS 46
bHLH_ScINO2_like cd11388
basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and ...
 650-714 1.49e-09

basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and similar proteins; INO2 is a positive regulatory factor required for depression of the co-regulated phospholipid biosynthetic enzymes in Saccharomyces cerevisiae. It is also involved in the expression of ITR1.


Pssm-ID: 381394  Cd Length: 68  Bit Score: 54.67  E-value: 1.49e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14602433 650 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAGLQEEA 714
Cdd:cd11388   3 KKWKHVEAEKKRRNQIKKGFEDLINLINYPRNNNEKRISKSELLNKAVDDIRGLLKANEQLQEEI 67
HLH smart00353
helix loop helix domain;
657-706 4.06e-09

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 52.99  E-value: 4.06e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 14602433    657 AEQKRRFNIKLGFDTLHGLVSTLsaQPSLKVSKATTLQKTAEYILMLQQE 706
Cdd:smart00353   3 RERRRRRKINEAFDELRSLLPTL--PKNKKLSKAEILRLAIEYIKSLQEE 50
bHLH_scINO4_like cd11403
basic Helix-Loop-Helix (bHLH) domain found in Saccharomyces cerevisiae INO4 and similar ...
 650-714 6.73e-09

basic Helix-Loop-Helix (bHLH) domain found in Saccharomyces cerevisiae INO4 and similar proteins; INO4 is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast. INO4 dimerizes with INO2 and binds to an UAS DNA element to control expression of the genes whose expression is inositol-responsive.


Pssm-ID: 381409  Cd Length: 71  Bit Score: 53.24  E-value: 6.73e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14602433 650 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLkvSKATTLQKTAEYILMLQQERAGLQEEA 714
Cdd:cd11403   2 KKENHISSEHKRREAIREGFDRLCAIVPALSSSQSR--SEAVVYVKTVEYLKELYERRAKLRSQL 64
bHLHzip_TFAP4 cd11419
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and ...
 650-710 2.47e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.


Pssm-ID: 381425  Cd Length: 61  Bit Score: 48.46  E-value: 2.47e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14602433 650 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQpslKVSKATTLQKTAEYILMLQQERAGL 710
Cdd:cd11419   4 RREIANSNERRRMQSINAGFQSLRTLLPHCDGE---KLSKAAILQQTAEYIFSLEQEKTRL 61
bHLHzip_Max cd11406
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, ...
 650-718 1.57e-06

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, also termed Class D basic helix-loop-helix protein 4 (bHLHd4), or Myc-associated factor X, is a bHLHZip transcription regulator that forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a transcriptional repressor. Max homodimer bind DNA but is transcriptionally inactive. Targeted deletion of max results in early embryonic lethality in mice.


Pssm-ID: 381412  Cd Length: 69  Bit Score: 46.19  E-value: 1.57e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14602433 650 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQpslKVSKATTLQKTAEYILMLQQERAGLQEEAQQLR 718
Cdd:cd11406   1 KRAHHNALERKRRDHIKDSFHSLRDSVPSLQGE---KASRAQILKKATEYIQYMRRKNHTHQQDIDDLK 66
bHLHzip_MGA_like cd19682
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) ...
 651-718 2.14e-06

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) family; The MGA family includes MGA, Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins. MGA, also termed MAX dimerization protein 5 (MAD5), is a dual specificity T-box/ bHLHzip transcription factor that regulates the expression of both Max-network and T-box family target genes. It contains a Myc-like bHLHZip motif and requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG. In addition to the bHLHZip domain, MGA harbors a second DNA-binding domain, the T-box or T-domain. It thus binds the preferred Brachyury-binding sequence and represses transcription of reporter genes containing promoter-proximal Brachyury-binding sites. spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381525 [Multi-domain]  Cd Length: 65  Bit Score: 45.73  E-value: 2.14e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14602433 651 RITHISAEQKRRFNIKLGFDTLHGLVsTLSAQPslKVSKATTLQKTAEYILMLQQERAGLQEEAQQLR 718
Cdd:cd19682   1 RLRHKKRERERRSELRELFDKLKQLL-GLDSDE--KASKLAVLTEAIEEIQQLKREEDELQKEKARLT 65
bHLHzip_scCBP1 cd11398
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae ...
 650-726 1.66e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae centromere-binding protein 1 (CBP-1) and similar proteins; CBP-1, also termed centromere promoter factor 1 (CPF1), or centromere-binding factor 1 (CBF1), is a bHLHzip protein that is required for chromosome stability and methionine prototrophy. It binds as a homodimer to the centromere DNA elements I (CDEI, GTCACATG) region of the centromere that is required for optimal centromere function.


Pssm-ID: 381404 [Multi-domain]  Cd Length: 89  Bit Score: 43.87  E-value: 1.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433 650 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAqpslKVSKATTLQKTAEYILMLQQERAGLQEEAQ-------QLRDEIE 722
Cdd:cd11398   7 RRDNHKEVERRRRENINEGINELAALVPGNAR----EKNKGAILARAVEYIQELQETEAKNIEKWTleklltdQAIAELA 82


                ....
gi 14602433 723 ELNA 726
Cdd:cd11398  83 ALNE 86
bHLHzip_c-Myc cd11458
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in c-Myc and similar proteins; c-Myc, ...
 649-724 2.59e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in c-Myc and similar proteins; c-Myc, also termed Myc proto-oncogene protein, or Class E basic helix-loop-helix protein 39 (bHLHe39), or transcription factor p64, a bHLHZip proto-oncogene protein that functions as a transcription factor, which binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. It activates the transcription of growth-related genes.


Pssm-ID: 381464 [Multi-domain]  Cd Length: 84  Bit Score: 43.33  E-value: 2.59e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14602433 649 NRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPslKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDEIEEL 724
Cdd:cd11458   4 DKRRTHNVLERQRRNELKLSFFALRDQIPEVANNE--KAPKVVILKKATEYILSMQADEQRLISEKEQLRRRREQL 77
bHLH_TS_ASCL cd11418
basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The ...
 644-706 6.79e-05

basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The achaete-scute complex-like (ASCL, also known as achaete-scute complex homolog or ASH) family of bHLH transcription factors, ASCL1-5, have been implicated in cell fate specification and differentiation. They are critical for proper development of the nervous system. The deregulation of ASCL plays a key role in psychiatric and neurological disorders. ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete-scute homolog 1 (Mash1), is a neural-specific bHLH transcription factor that is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system. ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete-scute homolog 2 (Mash2), is a bHLH transcription factor that is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves. ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is a bHLH transcription factor specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis. The family also includes Drosophila melanogaster achaete-scute complex (AS-C) proteins, which consists of lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation.


Pssm-ID: 381424 [Multi-domain]  Cd Length: 56  Bit Score: 41.05  E-value: 6.79e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14602433 644 SNKTENRRITHISaeqkrrfnikLGFDTLHGLVSTLSaqPSLKVSKATTLQKTAEYILMLQQE 706
Cdd:cd11418   5 RNERERRRVQAVN----------DAFDRLRQHVPYLK--RRKKLSKVKTLRRAIEYIRHLQKL 55
bHLHzip_N-Myc_like cd11456
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins; N-Myc, ...
 650-724 6.96e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins; N-Myc, also termed Class E basic helix-loop-helix protein 37 (bHLHe37), is a bHLHZip proto-oncogene protein that positively regulates the transcription of MYCNOS in neuroblastoma cells. It is also essential during embryonic development. N-Myc has a critical role in regulating the switch between proliferation and differentiation of progenitor cells. It binds DNA as a heterodimer with MAX. The family also includes S-Myc, encoded by rat or mouse intronless myc gene, which has apoptosis-inducing activity.


Pssm-ID: 381462 [Multi-domain]  Cd Length: 87  Bit Score: 42.20  E-value: 6.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433 650 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPslKVSKATTLQKTAEYILMLQ-------QERAGLQEEAQQLRDEIE 722
Cdd:cd11456   5 RRRNHNILERQRRNDLRSSFLTLRDHVPELVKNE--KAAKVVILKKATEYVHSLQaeeqkllLEKEKLQARQQQLLKKIE 82


                ..
gi 14602433 723 EL 724
Cdd:cd11456  83 QA 84
bHLH_AtbHLH_like cd11393
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription ...
 654-705 7.89e-05

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription factors and similar proteins; bHLH proteins are the second largest class of plant transcription factors that regulate transcription of genes that are involve in many essential physiological and developmental process. bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. The Arabidopsis bHLH proteins that have been characterized so far have roles in regulation of fruit dehiscence, cell development (carpel, anther and epidermal), phytochrome signaling, flavonoid biosynthesis, hormone signaling and stress responses.


Pssm-ID: 381399 [Multi-domain]  Cd Length: 53  Bit Score: 41.01  E-value: 7.89e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 14602433 654 HISAEQKRRFNIKLGFDTLHGLVStlsaqPSLKVSKATTLQKTAEYILMLQQ 705
Cdd:cd11393   1 HSIAERKRREKINERIRALRSLVP-----NGGKTDKASILDEAIEYIKFLQE 47
bHLHzip_SREBP cd11394
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
 644-718 8.07e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box.


Pssm-ID: 381400 [Multi-domain]  Cd Length: 73  Bit Score: 41.49  E-value: 8.07e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14602433 644 SNKTEnRRITHISAEQKRRFNIKLGFDTLHGLVstlsAQPSLKVSKATTLQKTAEYILMLQQERAGLQEEAQQLR 718
Cdd:cd11394   1 PPKVE-KRSAHNAIEKRYRSSINDRIIELKDLV----VGPDAKMNKSAVLRKAIDYIRYLQKVNQKLKQENMALK 70
bHLHzip_scHMS1_like cd11399
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae transcription ...
 649-724 1.09e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae transcription factor HMS1 and similar proteins; HMS1, also termed high-copy MEP suppressor protein 1, is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation.


Pssm-ID: 381405 [Multi-domain]  Cd Length: 96  Bit Score: 42.08  E-value: 1.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433 649 NRRITHIS-------AEQKRRFNIKLGFDTLHGLvstlsaQPSLKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDEI 721
Cdd:cd11399  19 NDRIAELRdsvpalrEAYKSARGEDEDEEDLGGL------TPATKLNKATILSKATEYIRHLEKKNKRLSRENASLRERL 92


                ...
gi 14602433 722 EEL 724
Cdd:cd11399  93 AAH 95
bHLHzip_TFE3 cd18928
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and ...
 646-730 1.21e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins; TFE3, also termed Class E basic helix-loop-helix protein 33 (bHLHe33), is a bHLHzip transcription factor that is involved in B cell function. It specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Its efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF.


Pssm-ID: 381498 [Multi-domain]  Cd Length: 91  Bit Score: 41.57  E-value: 1.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433 646 KTENRRITHISAEQKRRFNIKLGFDTLHGLVSTlSAQPSLKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRdEIEELN 725
Cdd:cd18928   7 KERQKKDNHNLIERRRRFNINDRIKELGTLIPK-STDPEMRWNKGTILKASVDYIRKLQKEQQRSKEIEMRQR-KLEQAN 84


                ....*
gi 14602433 726 AAINL 730
Cdd:cd18928  85 RSLQL 89
bHLHzip_spESC1_like cd19690
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Schizosaccharomyces pombe ESC1 (spESC1) ...
 651-724 1.44e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins; spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381533  Cd Length: 65  Bit Score: 40.52  E-value: 1.44e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 14602433 651 RITHISAEQKRRFNIKLGFDTLHGLvstLSAQPSLKVSKATTLQKTAEYIlmlQQeragLQEEAQQLRDEIEEL 724
Cdd:cd19690   1 RVSHKLAERKRRKEMKELFEDLRDA---LPQERGTKASKWEILTKAISYI---QQ----LKRHIRELRSEVNDL 64
bHLH_SOHLH_like cd19683
basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific ...
 650-704 3.99e-04

basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein (SOHLH) family and similar proteins; The SOHLH family includes two bHLH transcription factors, SOHLH1 and SOHLH2. They are specifically in spermatogonia and oocytes and essential for early spermatogonial and oocyte differentiation. The family also includes transcription factor-like 5 protein (TCFL5) and similar proteins. TCFL5, also termed Cha transcription factor, or HPV-16 E2-binding protein 1 (E2BP-1), is a bHLH transcription factor that plays a crucial role in spermatogenesis. It regulates cell proliferation or differentiation of cells through binding to a specific DNA sequence like other bHLH molecules.


Pssm-ID: 381526  Cd Length: 58  Bit Score: 39.26  E-value: 3.99e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 14602433 650 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAqpslKVSKATTLQKTAEYILMLQ 704
Cdd:cd19683   2 SRERHNAKERQRRERIKIACDQLRKLVPGCSR----KTDKATVFEFTVAYIKFLR 52
PHA03247 PHA03247
large tegument protein UL36; Provisional
 306-633 5.39e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 5.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433   306 SRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRL-----QARNSCPGPLDSSAFLSSdfllPE 380
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLppgpaAARQASPALPAAPAPPAV----PA 2746

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433   381 DPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPA---------PGVSPLPA 451
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAavlapaaalPPAASPAG 2826

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433   452 PAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQ- 530
Cdd:PHA03247 2827 PLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPe 2906

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433   531 -LLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSP------ 603
Cdd:PHA03247 2907 rPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPqpapsr 2986

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 14602433   604 --PAPSGSERR-------------LSGDLSSMPGPGTLSVRVSPP 633
Cdd:PHA03247 2987 eaPASSTPPLTghslsrvsswassLALHEETDPPPVSLKQTLWPP 3031
bHLHzip_TFEC cd18925
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and ...
 646-727 5.62e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and similar proteins; TFEC, also termed Class E basic helix-loop-helix protein 34 (bHLHe34), or transcription factor EC-like (TFEC-L), is a bHLHzip transcriptional regulator that acts as a repressor or an activator and regulates gene expression in macrophages. It plays an important role in the niche to expand hematopoietic progenitors through the modulation of several cytokines.


Pssm-ID: 381495  Cd Length: 85  Bit Score: 39.68  E-value: 5.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433 646 KTENRRITHISAEQKRRFNIKLGFDTLHGLVSTlSAQPSLKVSKATTLQKTAEYILMLQQEraglQEEAQQLRDEIEELN 725
Cdd:cd18925   1 KERQKKDNHNLIERRRRYNINYRIKELGTLIPK-SNDPDMRWNKGTILKASVEYIKWLQKE----QQRARELEHRQKKLE 75


                ..
gi 14602433 726 AA 727
Cdd:cd18925  76 QA 77
bHLHzip_MITF cd18926
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated ...
 646-727 1.16e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins; MITF, also termed Class E basic helix-loop-helix protein 32 (bHLHe32), is a bHLHzip transcription factor that is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. It regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. It binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR).


Pssm-ID: 381496  Cd Length: 104  Bit Score: 39.30  E-value: 1.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433 646 KTENRRITHISAEQKRRFNIKLGFDTLHGLVSTlSAQPSLKVSKATTLQKTAEYILMLQQEraglQEEAQQLRDEIEELN 725
Cdd:cd18926   9 KERQKKDNHNLIERRRRFNINDRIKELGTLIPK-SNDPDMRWNKGTILKASVDYIRKLQRE----QQRAKELENRQKKLE 83


                ..
gi 14602433 726 AA 727
Cdd:cd18926  84 HA 85
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
441-642 2.85e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 2.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433  441 PPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTT 520
Cdd:PRK12323 373 GPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAP 452

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433  521 AGSNNPCLTQLLTAAKPE----QALEPPLVSSTLLRSPGSPQETVP--EFPCTFLPPTPAPTPPRPPPGPATLAPSRPLL 594
Cdd:PRK12323 453 APAAAPAAAARPAAAGPRpvaaAAAAAPARAAPAAAPAPADDDPPPweELPPEFASPAPAQPDAAPAGWVAESIPDPATA 532

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 14602433  595 VPKAER----LSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQ-----PILSRGRP 642
Cdd:PRK12323 533 DPDDAFetlaPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMfdgdwPALAARLP 589
bHLHzip_USF_MITF cd11387
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream ...
 653-706 3.09e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream stimulatory factor)/MITF (microphthalmia-associated transcription factor) family includes two bHLHzip transcription factor subfamilies. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements. The MITF (also known as microphthalmia-TFE, or MiT) subfamily comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF subfamily proteins can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381393 [Multi-domain]  Cd Length: 58  Bit Score: 36.46  E-value: 3.09e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 14602433 653 THISAEQKRRFNIKLGFDTLHGLV-STLSAQPSLKVSKATTLQKTAEYILMLQQE 706
Cdd:cd11387   1 SHNAVERRRRDNINEKIQELGSLVpPSRLETKDLKPNKGSILSKAVEYIRELQNQ 55
PHA03378 PHA03378
EBNA-3B; Provisional
 319-635 3.20e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.21  E-value: 3.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433  319 EPPSFSPVVDSLFSSGTLGP-EVPPASSAMTHlsghsrlQARNSCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLH 397
Cdd:PHA03378 552 EPASTEPVHDQLLPAPGLGPlQIQPLTSPTTS-------QLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQW 624

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433  398 YPPPAKVPglepcppppfppmaPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPA--PTPFPIELL 475
Cdd:PHA03378 625 PMPLRPIP--------------MRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTgaNTMLPIQWA 690

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433  476 PLGYSEPAFGPCFSMPRGKPPAPSPRGQKAS----PPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTll 551
Cdd:PHA03378 691 PGTMQPPPRAPTPMRPPAAPPGRAQRPAAATgrarPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPA-- 768

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14602433  552 RSPGSPQETVPefpctflppTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVS 631
Cdd:PHA03378 769 AAPGAPTPQPP---------PQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPS 839


                 ....
gi 14602433  632 PPQP 635
Cdd:PHA03378 840 LKKP 843
bHLH_AtPRE_like cd11442
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana paclobutrazol resistance ...
 655-720 6.49e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana paclobutrazol resistance (PRE) family; The PRE family includes several bHLH transcription factors from Arabidopsis thaliana, such as PRE1-6. PRE1 (also termed AtbHLH136, or protein banquo 1), PRE2 (also termed AtbHLH134, or protein banquo 2, or EN 52), PRE4 (also termed AtbHLH161, or protein banquo 3), and PRE5 (also termed AtbHLH164) are atypical and probable non DNA-binding bHLH transcription factors that integrate multiple signaling pathways to regulate cell elongation and plant development. PRE3 (also termed AtbHLH135, or protein activation-tagged BRI1 suppressor 1, or ATBS1, or protein target of MOOPTEROS 7, or EN 67) is an atypical and probable non DNA-binding bHLH transcription factor required for MONOPTEROS-dependent root initiation in embryo. It promotes the correct definition of the hypophysis cell division plane. PRE5 (also termed AtbHLH163, or protein KIDARI) is an atypical and probable non DNA-binding bHLH transcription factor that regulates light-mediated responses in day light conditions by binding and inhibiting the activity of the bHLH transcription factor HFR1, a critical regulator of light signaling and shade avoidance.


Pssm-ID: 381448  Cd Length: 65  Bit Score: 35.74  E-value: 6.49e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14602433 655 ISAEQKRRFNIKLgfdtlHGLVSTLSAQPslKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDE 720
Cdd:cd11442   7 ISDDQKNDLYSRL-----RALLPSIATSD--KVSKATVLEEACNYIRNLHREVDDLSERLSRLLTS 65
bHLH_TS cd11390
tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain ...
 651-705 7.58e-03

tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain family includes transcription regulators whose expression are restricted to certain tissues. They are involved in cell-fate determination and process in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis and include proteins from myogenic regulatory factor (MRF) family, twist-related protein (TWIST) family, scleraxis-like family, heart- and neural crest derivatives-expressed protein (HAND) family, helix-loop-helix protein (HEN) family, musculin-like family, germline alpha (FIGLA) family, T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family, ovary, uterus and testis protein (OUT) family, mesoderm posterior protein (Mesp) family, muscle, intestine and stomach expression 1 (MIST-1) family, protein atonal homologs (ATOH) family, neurogenin (NGN) family, neurogenic differentiation factor (NeuroD) family, achaete-scute complex-like (ASCL) family, Fer3-like protein (FERD3L)-like family, and Oligodendrocyte lineage genes (OLIG) family of transcription factors.


Pssm-ID: 381396 [Multi-domain]  Cd Length: 55  Bit Score: 35.24  E-value: 7.58e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 14602433 651 RITHISAEQKRRFNIKLGFDTLHGLVSTLsaQPSLKVSKATTLQKTAEYILMLQQ 705
Cdd:cd11390   1 RNAANARERRRMHDLNDAFEALRKVLPTV--PPDKKLSKIETLRLAINYIAALSD 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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