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Conserved domains on  [gi|14589916|ref|NP_116586|]
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protocadherin-10 isoform 1 precursor [Homo sapiens]

Protein Classification

protocadherin( domain architecture ID 11175748)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 19-101 2.42e-39

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 140.36  E-value: 2.42e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916     19 QLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSRTPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVF 98
Cdd:pfam08266    1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                   ...
gi 14589916     99 LEN 101
Cdd:pfam08266   81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 254-354 1.65e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.35  E-value: 1.65e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916  254 VYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSShisPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDL 333
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS---GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 14589916  334 GPNAVPAHCKVLVRVLDANDN 354
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 590-680 3.65e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 3.65e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916  590 LPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRTARRVPakRDPQRPYELVIEVRDHGQPPLS 669
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLD--REEQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|.
gi 14589916  670 STATLVVQLVD 680
Cdd:cd11304   84 STATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 367-459 3.91e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 3.91e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916  367 VSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVP---FRLKSsfkNYYTIVTEAPLDREAGDSYTLTVVARDRGEPAL 443
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*.
gi 14589916  444 STSKSIQVQVSDVNDN 459
Cdd:cd11304   83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 467-570 4.70e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.16  E-value: 4.70e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916  467 VYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGmsvftYVSINSENGYLYALRSFDYEQLKDFSFQVEAR 546
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....
gi 14589916  547 DAGSPQaLAGNATVNILIVDQNDN 570
Cdd:cd11304   76 DGGGPP-LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 128-246 1.11e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 1.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916  128 TVEISESATPGTRFPLESAFDPDVGTNSLRDYEIT---PNSYFSLDVQTqgdgnrfAELVLEKPLDREQQAVHRYVLTAV 204
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDPST-------GEITTAKPLDREEQSSYTLTVTAT 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 14589916  205 DggggggvgegggggggaglPPQQQRTGTALLTIRVLDSNDN 246
Cdd:cd11304   76 D-------------------GGGPPLSSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 713-838 8.73e-18

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 79.11  E-value: 8.73e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916    713 DLTLILIIALGSVSFIFLLAMIVL-AVRCQKEKKLNIYTCLASDCClcccccggggstccgrqararkkklsksdimlVQ 791
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLiALRLRRWRSSALLQSSGNLCS--------------------------------VP 48

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 14589916    792 SSNVPSNpaqvpieesGGFGSHHhnQNYCYQVCLTPESAKTDLMFLK 838
Cdd:pfam16492   49 APHFPGN---------DGTGTLP--QSYSYEVCLTSDSGKSEFKFLK 84
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 19-101 2.42e-39

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 140.36  E-value: 2.42e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916     19 QLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSRTPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVF 98
Cdd:pfam08266    1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                   ...
gi 14589916     99 LEN 101
Cdd:pfam08266   81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 254-354 1.65e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.35  E-value: 1.65e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916  254 VYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSShisPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDL 333
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS---GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 14589916  334 GPNAVPAHCKVLVRVLDANDN 354
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 590-680 3.65e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 3.65e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916  590 LPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRTARRVPakRDPQRPYELVIEVRDHGQPPLS 669
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLD--REEQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|.
gi 14589916  670 STATLVVQLVD 680
Cdd:cd11304   84 STATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 367-459 3.91e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 3.91e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916  367 VSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVP---FRLKSsfkNYYTIVTEAPLDREAGDSYTLTVVARDRGEPAL 443
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*.
gi 14589916  444 STSKSIQVQVSDVNDN 459
Cdd:cd11304   83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 467-570 4.70e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.16  E-value: 4.70e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916  467 VYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGmsvftYVSINSENGYLYALRSFDYEQLKDFSFQVEAR 546
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....
gi 14589916  547 DAGSPQaLAGNATVNILIVDQNDN 570
Cdd:cd11304   76 DGGGPP-LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 273-356 1.50e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 89.72  E-value: 1.50e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916     273 NATDPDEGQNGEVVYSFSShisPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDAN 352
Cdd:smart00112    1 SATDADSGENGKVTYSILS---GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 14589916     353 DNAP 356
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
590-678 1.80e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 1.80e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916    590 LPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRTARRVpaKRDPQRPYELVIEVRDHGQPPLS 669
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL--DRESIGEYELTVEATDSGGPPLS 82


                   ....*....
gi 14589916    670 STATLVVQL 678
Cdd:pfam00028   83 STATVTITV 91
Cadherin pfam00028
Cadherin domain;
255-349 8.31e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.74  E-value: 8.31e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916    255 YTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRareLFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLG 334
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG---NFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 14589916    335 PNAVPAHCKVLVRVL 349
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 381-461 6.35e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.09  E-value: 6.35e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916     381 SVTDRDSEENGQVQCELLGDVPFRLkssFK---NYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVN 457
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGL---FSidpETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 14589916     458 DNAP 461
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 486-572 9.55e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.32  E-value: 9.55e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916     486 SATDRDEGANAQLAYSILecqiQGmSVFTYVSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQaLAGNATVNILIV 565
Cdd:smart00112    1 SATDADSGENGKVTYSIL----SG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP-LSSTATVTITVL 74


                    ....*..
gi 14589916     566 DQNDNAP 572
Cdd:smart00112   75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 605-680 9.64e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.32  E-value: 9.64e-20
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14589916     605 AVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRTARRVpaKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPL--DREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 128-246 1.11e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 1.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916  128 TVEISESATPGTRFPLESAFDPDVGTNSLRDYEIT---PNSYFSLDVQTqgdgnrfAELVLEKPLDREQQAVHRYVLTAV 204
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDPST-------GEITTAKPLDREEQSSYTLTVTAT 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 14589916  205 DggggggvgegggggggaglPPQQQRTGTALLTIRVLDSNDN 246
Cdd:cd11304   76 D-------------------GGGPPLSSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 713-838 8.73e-18

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 79.11  E-value: 8.73e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916    713 DLTLILIIALGSVSFIFLLAMIVL-AVRCQKEKKLNIYTCLASDCClcccccggggstccgrqararkkklsksdimlVQ 791
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLiALRLRRWRSSALLQSSGNLCS--------------------------------VP 48

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 14589916    792 SSNVPSNpaqvpieesGGFGSHHhnQNYCYQVCLTPESAKTDLMFLK 838
Cdd:pfam16492   49 APHFPGN---------DGTGTLP--QSYSYEVCLTSDSGKSEFKFLK 84
Cadherin pfam00028
Cadherin domain;
468-564 3.99e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.56  E-value: 3.99e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916    468 YDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMsvFTyvsINSENGYLYALRSFDYEQLKDFSFQVEARD 547
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN--FR---IDPDTGDISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*..
gi 14589916    548 AGSPqALAGNATVNILI 564
Cdd:pfam00028   76 SGGP-PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
367-453 5.60e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 5.60e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916    367 VSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFRlksSFK-NYYT--IVTEAPLDREAGDSYTLTVVARDRGEPAL 443
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG---NFRiDPDTgdISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|
gi 14589916    444 STSKSIQVQV 453
Cdd:pfam00028   82 SSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 145-248 1.25e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 1.25e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916     145 SAFDPDVGTNSLRDYEITPNS---YFSLDVQTQgdgnrfaELVLEKPLDREQQAVHRYVLTAVDGGggggvgeggggggg 221
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNddgLFSIDPETG-------EITTTKPLDREEQPEYTLTVEATDGG-------------- 59

                            90       100
                    ....*....|....*....|....*..
gi 14589916     222 aglppQQQRTGTALLTIRVLDSNDNVP 248
Cdd:smart00112   60 -----GPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 21-118 8.60e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.55  E-value: 8.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916   21 HYTVQEEQEHGTFVGNI-AEDLglDITKLSARGFQTVPNSRTPYLDLNLETGVLYVNEKIDREQIckqspsCVLHLEVFL 99
Cdd:cd11304    3 EVSVPENAPPGTVVLTVsATDP--DSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTLTVTA 74

                         90       100
                 ....*....|....*....|....
gi 14589916  100 ENPLELF-----QVEIEVLDINDN 118
Cdd:cd11304   75 TDGGGPPlsstaTVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
128-241 5.74e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.45  E-value: 5.74e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916    128 TVEISESATPGTRFPLESAFDPDVGTNSLRDYEIT---PNSYFSLDVQTQgdgnrfaELVLEKPLDREQQAVHRYVLTAV 204
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEAT 74

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 14589916    205 DGGggggvgegggggggaglppQQQRTGTALLTIRVL 241
Cdd:pfam00028   75 DSG-------------------GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 56-120 5.00e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 42.72  E-value: 5.00e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14589916      56 VPNSRTPYLDLNLETGVLYVNEKIDREQIckqsPSCVLHLEVFLENPLELF---QVEIEVLDINDNPP 120
Cdd:smart00112   18 LSGNDDGLFSIDPETGEITTTKPLDREEQ----PEYTLTVEATDGGGPPLSstaTVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 19-101 2.42e-39

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 140.36  E-value: 2.42e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916     19 QLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSRTPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVF 98
Cdd:pfam08266    1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                   ...
gi 14589916     99 LEN 101
Cdd:pfam08266   81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 254-354 1.65e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.35  E-value: 1.65e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916  254 VYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSShisPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDL 333
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS---GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 14589916  334 GPNAVPAHCKVLVRVLDANDN 354
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 590-680 3.65e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 3.65e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916  590 LPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRTARRVPakRDPQRPYELVIEVRDHGQPPLS 669
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLD--REEQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|.
gi 14589916  670 STATLVVQLVD 680
Cdd:cd11304   84 STATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 367-459 3.91e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 3.91e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916  367 VSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVP---FRLKSsfkNYYTIVTEAPLDREAGDSYTLTVVARDRGEPAL 443
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*.
gi 14589916  444 STSKSIQVQVSDVNDN 459
Cdd:cd11304   83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 467-570 4.70e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.16  E-value: 4.70e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916  467 VYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGmsvftYVSINSENGYLYALRSFDYEQLKDFSFQVEAR 546
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....
gi 14589916  547 DAGSPQaLAGNATVNILIVDQNDN 570
Cdd:cd11304   76 DGGGPP-LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 273-356 1.50e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 89.72  E-value: 1.50e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916     273 NATDPDEGQNGEVVYSFSShisPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDAN 352
Cdd:smart00112    1 SATDADSGENGKVTYSILS---GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 14589916     353 DNAP 356
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
590-678 1.80e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 1.80e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916    590 LPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRTARRVpaKRDPQRPYELVIEVRDHGQPPLS 669
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL--DRESIGEYELTVEATDSGGPPLS 82


                   ....*....
gi 14589916    670 STATLVVQL 678
Cdd:pfam00028   83 STATVTITV 91
Cadherin pfam00028
Cadherin domain;
255-349 8.31e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.74  E-value: 8.31e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916    255 YTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRareLFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLG 334
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG---NFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 14589916    335 PNAVPAHCKVLVRVL 349
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 381-461 6.35e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.09  E-value: 6.35e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916     381 SVTDRDSEENGQVQCELLGDVPFRLkssFK---NYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVN 457
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGL---FSidpETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 14589916     458 DNAP 461
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 486-572 9.55e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.32  E-value: 9.55e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916     486 SATDRDEGANAQLAYSILecqiQGmSVFTYVSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQaLAGNATVNILIV 565
Cdd:smart00112    1 SATDADSGENGKVTYSIL----SG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP-LSSTATVTITVL 74


                    ....*..
gi 14589916     566 DQNDNAP 572
Cdd:smart00112   75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 605-680 9.64e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.32  E-value: 9.64e-20
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14589916     605 AVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRTARRVpaKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPL--DREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 128-246 1.11e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 1.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916  128 TVEISESATPGTRFPLESAFDPDVGTNSLRDYEIT---PNSYFSLDVQTqgdgnrfAELVLEKPLDREQQAVHRYVLTAV 204
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDPST-------GEITTAKPLDREEQSSYTLTVTAT 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 14589916  205 DggggggvgegggggggaglPPQQQRTGTALLTIRVLDSNDN 246
Cdd:cd11304   76 D-------------------GGGPPLSSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 713-838 8.73e-18

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 79.11  E-value: 8.73e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916    713 DLTLILIIALGSVSFIFLLAMIVL-AVRCQKEKKLNIYTCLASDCClcccccggggstccgrqararkkklsksdimlVQ 791
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLiALRLRRWRSSALLQSSGNLCS--------------------------------VP 48

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 14589916    792 SSNVPSNpaqvpieesGGFGSHHhnQNYCYQVCLTPESAKTDLMFLK 838
Cdd:pfam16492   49 APHFPGN---------DGTGTLP--QSYSYEVCLTSDSGKSEFKFLK 84
Cadherin pfam00028
Cadherin domain;
468-564 3.99e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.56  E-value: 3.99e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916    468 YDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMsvFTyvsINSENGYLYALRSFDYEQLKDFSFQVEARD 547
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN--FR---IDPDTGDISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*..
gi 14589916    548 AGSPqALAGNATVNILI 564
Cdd:pfam00028   76 SGGP-PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
367-453 5.60e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 5.60e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916    367 VSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFRlksSFK-NYYT--IVTEAPLDREAGDSYTLTVVARDRGEPAL 443
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG---NFRiDPDTgdISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|
gi 14589916    444 STSKSIQVQV 453
Cdd:pfam00028   82 SSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 145-248 1.25e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 1.25e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916     145 SAFDPDVGTNSLRDYEITPNS---YFSLDVQTQgdgnrfaELVLEKPLDREQQAVHRYVLTAVDGGggggvgeggggggg 221
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNddgLFSIDPETG-------EITTTKPLDREEQPEYTLTVEATDGG-------------- 59

                            90       100
                    ....*....|....*....|....*..
gi 14589916     222 aglppQQQRTGTALLTIRVLDSNDNVP 248
Cdd:smart00112   60 -----GPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 21-118 8.60e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.55  E-value: 8.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916   21 HYTVQEEQEHGTFVGNI-AEDLglDITKLSARGFQTVPNSRTPYLDLNLETGVLYVNEKIDREQIckqspsCVLHLEVFL 99
Cdd:cd11304    3 EVSVPENAPPGTVVLTVsATDP--DSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTLTVTA 74

                         90       100
                 ....*....|....*....|....
gi 14589916  100 ENPLELF-----QVEIEVLDINDN 118
Cdd:cd11304   75 TDGGGPPlsstaTVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 22-118 1.02e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 53.89  E-value: 1.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916   22 YTVQEEQEHGTFVGNIAEDLGLDIT---KLSARGFQTVPNsrtpYLDLNLETGVLYVNEKIDREQIckqspsCVLHLEVF 98
Cdd:cd00031    4 GSAVEGRSRGSFRVSIPTDLIASSGeiiKISAAGKEALPS----WLHWEPHSGILEGLEKLDREDK------GVHYISVS 73

                         90       100
                 ....*....|....*....|....*
gi 14589916   99 L-----ENPLELFQVEIEVLDINDN 118
Cdd:cd00031   74 AaslgaNVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
128-241 5.74e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.45  E-value: 5.74e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589916    128 TVEISESATPGTRFPLESAFDPDVGTNSLRDYEIT---PNSYFSLDVQTQgdgnrfaELVLEKPLDREQQAVHRYVLTAV 204
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEAT 74

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 14589916    205 DGGggggvgegggggggaglppQQQRTGTALLTIRVL 241
Cdd:pfam00028   75 DSG-------------------GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 56-120 5.00e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 42.72  E-value: 5.00e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14589916      56 VPNSRTPYLDLNLETGVLYVNEKIDREQIckqsPSCVLHLEVFLENPLELF---QVEIEVLDINDNPP 120
Cdd:smart00112   18 LSGNDDGLFSIDPETGEITTTKPLDREEQ----PEYTLTVEATDGGGPPLSstaTVTITVLDVNDNAP 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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