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Conserved domains on  [gi|15221246|ref|NP_172683|]
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F-box and associated interaction domains-containing protein [Arabidopsis thaliana]

Protein Classification

F-box protein( domain architecture ID 17779041)

F-box protein is the substrate-recognition component of an SCF (Skp1-cullin-F-box protein) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515
PubMed:  31898225|11178263
SCOP:  4001927

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 95-337 9.86e-59

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


:

Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 190.26  E-value: 9.86e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221246    95 FLPCNDLLfCASWWsNKAVVWNPSLRQTRLIKSGE-----EHFRFGGIGYDSgrPGKGYHIFGHSHSRLSVNgntskfIK 169
Cdd:TIGR01640   1 VVPCDGLI-CFSYG-KRLVVWNPSTGQSRWLPTPKsrrsnKESDTYFLGYDP--IEKQYKVLCFSDRSGNRN------QS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221246   170 RFYITKFESNAWKCIddvslgENSIGGDSLDNNNVSLNGNLYWTTNSYDTDE-YLIQSFDFSKEIFKIFCVLPRKK-DSS 247
Cdd:TIGR01640  71 EHQVYTLGSNSWRTI------ECSPPHHPLKSRGVCINGVLYYLAYTLKTNPdYFIVSFDVSSERFKEFIPLPCGNsDSV 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221246   248 DIPVLSVFRGdRLSVLHKFKGTNNMEIWVTKNKINesvkaVVWMMFMTVSIPIYKD----SKPSYFINdiyEKRLVMCCS 323
Cdd:TIGR01640 145 DYLSLINYKG-KLAVLKQKKDTNNFDLWVLNDAGK-----QEWSKLFTVPIPPLPDlvddNFLSGFTD---KGEIVLCCE 215

                         250
                  ....*....|....*
gi 15221246   324 DENGK-ACVYIVKDQ 337
Cdd:TIGR01640 216 DENPFyIFYYNVGEN 230
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 6-42 3.87e-10

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438928  Cd Length: 39  Bit Score: 54.39  E-value: 3.87e-10
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 15221246   6 FPWELMEEILYRVPSLSLSRFKTVSKEWNTLLNDKTF 42
Cdd:cd22157   3 LPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
 
Name Accession Description Interval E-value
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 95-337 9.86e-59

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 190.26  E-value: 9.86e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221246    95 FLPCNDLLfCASWWsNKAVVWNPSLRQTRLIKSGE-----EHFRFGGIGYDSgrPGKGYHIFGHSHSRLSVNgntskfIK 169
Cdd:TIGR01640   1 VVPCDGLI-CFSYG-KRLVVWNPSTGQSRWLPTPKsrrsnKESDTYFLGYDP--IEKQYKVLCFSDRSGNRN------QS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221246   170 RFYITKFESNAWKCIddvslgENSIGGDSLDNNNVSLNGNLYWTTNSYDTDE-YLIQSFDFSKEIFKIFCVLPRKK-DSS 247
Cdd:TIGR01640  71 EHQVYTLGSNSWRTI------ECSPPHHPLKSRGVCINGVLYYLAYTLKTNPdYFIVSFDVSSERFKEFIPLPCGNsDSV 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221246   248 DIPVLSVFRGdRLSVLHKFKGTNNMEIWVTKNKINesvkaVVWMMFMTVSIPIYKD----SKPSYFINdiyEKRLVMCCS 323
Cdd:TIGR01640 145 DYLSLINYKG-KLAVLKQKKDTNNFDLWVLNDAGK-----QEWSKLFTVPIPPLPDlvddNFLSGFTD---KGEIVLCCE 215

                         250
                  ....*....|....*
gi 15221246   324 DENGK-ACVYIVKDQ 337
Cdd:TIGR01640 216 DENPFyIFYYNVGEN 230
FBA_1 pfam07734
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 204-359 6.50e-45

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


Pssm-ID: 254394  Cd Length: 159  Bit Score: 151.99  E-value: 6.50e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221246   204 VSLNGNLYWTT-NSYDTDEYLIQSFDFSKEIFKIFCVLPRKKDSSDIPVLSVFRGDRLSVLHKFKGTNNMEIWVTkNKIN 282
Cdd:pfam07734   2 VSLKGNTYWLArEKETNEEDFLLSFDFTTERFGPRLPLPFQSPDLDTVSLSVVREEKLAVLLQEDDTSKIEIWVT-TKIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221246   283 ESvkAVVWMMFMTVSIPI-----YKDSKPSYFINDiyEKRLVMCCSDENGK--ACVYIVkDQARKKIQLGFHVSEFSHCF 355
Cdd:pfam07734  81 PN--AVSWSKFLTVDMPPlpglfFHFFAGSFFIDE--EKKVAVVCDKDKEKktNTIYII-GEDGYFKEVDSSYCSPLVCS 155


                  ....
gi 15221246   356 YDPS 359
Cdd:pfam07734 156 YVPS 159
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 6-42 3.87e-10

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 54.39  E-value: 3.87e-10
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 15221246   6 FPWELMEEILYRVPSLSLSRFKTVSKEWNTLLNDKTF 42
Cdd:cd22157   3 LPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
FBOX smart00256
A Receptor for Ubiquitination Targets;
6-46 2.29e-04

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 38.19  E-value: 2.29e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15221246      6 FPWELMEEILYRVPSLSLSRFKTVSKEWNTLLNDKTFIKKH 46
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 5-45 6.79e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 34.05  E-value: 6.79e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15221246     5 KFPWELMEEILYRVPSLSLSRFKTVSKEWNTLLNDKTFIKK 45
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
 
Name Accession Description Interval E-value
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 95-337 9.86e-59

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 190.26  E-value: 9.86e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221246    95 FLPCNDLLfCASWWsNKAVVWNPSLRQTRLIKSGE-----EHFRFGGIGYDSgrPGKGYHIFGHSHSRLSVNgntskfIK 169
Cdd:TIGR01640   1 VVPCDGLI-CFSYG-KRLVVWNPSTGQSRWLPTPKsrrsnKESDTYFLGYDP--IEKQYKVLCFSDRSGNRN------QS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221246   170 RFYITKFESNAWKCIddvslgENSIGGDSLDNNNVSLNGNLYWTTNSYDTDE-YLIQSFDFSKEIFKIFCVLPRKK-DSS 247
Cdd:TIGR01640  71 EHQVYTLGSNSWRTI------ECSPPHHPLKSRGVCINGVLYYLAYTLKTNPdYFIVSFDVSSERFKEFIPLPCGNsDSV 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221246   248 DIPVLSVFRGdRLSVLHKFKGTNNMEIWVTKNKINesvkaVVWMMFMTVSIPIYKD----SKPSYFINdiyEKRLVMCCS 323
Cdd:TIGR01640 145 DYLSLINYKG-KLAVLKQKKDTNNFDLWVLNDAGK-----QEWSKLFTVPIPPLPDlvddNFLSGFTD---KGEIVLCCE 215

                         250
                  ....*....|....*
gi 15221246   324 DENGK-ACVYIVKDQ 337
Cdd:TIGR01640 216 DENPFyIFYYNVGEN 230
FBA_1 pfam07734
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 204-359 6.50e-45

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


Pssm-ID: 254394  Cd Length: 159  Bit Score: 151.99  E-value: 6.50e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221246   204 VSLNGNLYWTT-NSYDTDEYLIQSFDFSKEIFKIFCVLPRKKDSSDIPVLSVFRGDRLSVLHKFKGTNNMEIWVTkNKIN 282
Cdd:pfam07734   2 VSLKGNTYWLArEKETNEEDFLLSFDFTTERFGPRLPLPFQSPDLDTVSLSVVREEKLAVLLQEDDTSKIEIWVT-TKIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221246   283 ESvkAVVWMMFMTVSIPI-----YKDSKPSYFINDiyEKRLVMCCSDENGK--ACVYIVkDQARKKIQLGFHVSEFSHCF 355
Cdd:pfam07734  81 PN--AVSWSKFLTVDMPPlpglfFHFFAGSFFIDE--EKKVAVVCDKDKEKktNTIYII-GEDGYFKEVDSSYCSPLVCS 155


                  ....
gi 15221246   356 YDPS 359
Cdd:pfam07734 156 YVPS 159
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 6-42 3.87e-10

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 54.39  E-value: 3.87e-10
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 15221246   6 FPWELMEEILYRVPSLSLSRFKTVSKEWNTLLNDKTF 42
Cdd:cd22157   3 LPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
FBOX smart00256
A Receptor for Ubiquitination Targets;
6-46 2.29e-04

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 38.19  E-value: 2.29e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15221246      6 FPWELMEEILYRVPSLSLSRFKTVSKEWNTLLNDKTFIKKH 46
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 5-45 6.79e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 34.05  E-value: 6.79e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15221246     5 KFPWELMEEILYRVPSLSLSRFKTVSKEWNTLLNDKTFIKK 45
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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