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Conserved domains on  [gi|15230439|ref|NP_190696|]
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Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
48-278 1.01e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 73.50  E-value: 1.01e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439  48 NVQLVEKDPERAIPLFWKAINAGDRVDSALKDMAIVMKQQNRAEEAIEAIkslrvrcsDQAQEsLDNILLDLYKRCGRLD 127
Cdd:COG0457  16 LAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADY--------EQALE-LDPDDAEALNNLGLAL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439 128 DQIGLLKHKLFLIQKGLAFNGKRTKTarsqgkkfqvsveqeatrlLGNLGWALMQRDNFVEAEDAYRRALSIAPDN-NKM 206
Cdd:COG0457  87 QALGRYEEALEDYDKALELDPDDAEA-------------------LYNLGLALLELGRYDEAIEAYERALELDPDDaDAL 147

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15230439 207 CNLGICLMKQGRIDEAKETLRRVKPAVVDGPRGVDSHLKAYERAQQMLNDLGSEMMRRGGDDKVEQRRLFDA 278
Cdd:COG0457 148 YNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAAL 219
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
48-278 1.01e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 73.50  E-value: 1.01e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439  48 NVQLVEKDPERAIPLFWKAINAGDRVDSALKDMAIVMKQQNRAEEAIEAIkslrvrcsDQAQEsLDNILLDLYKRCGRLD 127
Cdd:COG0457  16 LAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADY--------EQALE-LDPDDAEALNNLGLAL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439 128 DQIGLLKHKLFLIQKGLAFNGKRTKTarsqgkkfqvsveqeatrlLGNLGWALMQRDNFVEAEDAYRRALSIAPDN-NKM 206
Cdd:COG0457  87 QALGRYEEALEDYDKALELDPDDAEA-------------------LYNLGLALLELGRYDEAIEAYERALELDPDDaDAL 147

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15230439 207 CNLGICLMKQGRIDEAKETLRRVKPAVVDGPRGVDSHLKAYERAQQMLNDLGSEMMRRGGDDKVEQRRLFDA 278
Cdd:COG0457 148 YNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAAL 219
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 179-287 2.12e-06

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 49.16  E-value: 2.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439 179 ALMQRDNFVEAEDAYRRALSIAPDNNK-MCNLGICLMKQGRIDEAKETLRRvkpAV-----------------VDGPRGV 240
Cdd:cd24142   9 ELLDQGNFELALKFLQRALELEPNNVEaLELLGEILLELGDVEEAREVLLR---AIeldpdggyekylylgqlSGGEEAL 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15230439 241 DSHLKAYERAQQMLNDLGSEMMRRGGDDKVEQRRLFDAIFGSSSIWQ 287
Cdd:cd24142  86 QYYEKGIEILEEELQALQAASAEAEEEAEELKRKLSSALCALAEIYM 132
TPR_19 pfam14559
Tetratricopeptide repeat;
185-238 3.54e-06

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 44.11  E-value: 3.54e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 15230439   185 NFVEAEDAYRRALSIAPDNNKMC-NLGICLMKQGRIDEAKETLRRVKPAVVDGPR 238
Cdd:pfam14559   3 DYAEALELLEQALAEDPDNAEARlGLAEALLALGRLDEAEALLAALPAADPDDPR 57
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 48-230 5.13e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.93  E-value: 5.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439    48 NVQLVEKDPERAIPLFWKAINAGDRVDSALKDMAIVMKQQNRAEEAIEAIKSLRVRCSDQAQESLdniLLDLYKRCGRLD 127
Cdd:TIGR02917 711 DLYLRQKDYPAAIQAYRKALKRAPSSQNAIKLHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTA---LAELYLAQKDYD 787

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439   128 DQIgllKHKLFLIQK---------GLAF---NGKRTKTARSQGKKFQVSVEQEAtrLLGNLGWALMQRDNFVEAEDAYRR 195
Cdd:TIGR02917 788 KAI---KHYQTVVKKapdnavvlnNLAWlylELKDPRALEYAERALKLAPNIPA--ILDTLGWLLVEKGEADRALPLLRK 862

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 15230439   196 ALSIAPDNNKM-CNLGICLMKQGRIDEAKETLRRVK 230
Cdd:TIGR02917 863 AVNIAPEAAAIrYHLALALLATGRKAEARKELDKLL 898
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 171-203 1.83e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 41.28  E-value: 1.83e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 15230439    171 RLLGNLGWALMQRDNFVEAEDAYRRALSIAPDN 203
Cdd:smart00028   2 EALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
48-278 1.01e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 73.50  E-value: 1.01e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439  48 NVQLVEKDPERAIPLFWKAINAGDRVDSALKDMAIVMKQQNRAEEAIEAIkslrvrcsDQAQEsLDNILLDLYKRCGRLD 127
Cdd:COG0457  16 LAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADY--------EQALE-LDPDDAEALNNLGLAL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439 128 DQIGLLKHKLFLIQKGLAFNGKRTKTarsqgkkfqvsveqeatrlLGNLGWALMQRDNFVEAEDAYRRALSIAPDN-NKM 206
Cdd:COG0457  87 QALGRYEEALEDYDKALELDPDDAEA-------------------LYNLGLALLELGRYDEAIEAYERALELDPDDaDAL 147

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15230439 207 CNLGICLMKQGRIDEAKETLRRVKPAVVDGPRGVDSHLKAYERAQQMLNDLGSEMMRRGGDDKVEQRRLFDA 278
Cdd:COG0457 148 YNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAAL 219
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 48-257 3.04e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 63.59  E-value: 3.04e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439  48 NVQLVEKDPERAIPLFWKAINAGDRVDSALKDMAIVMKQQNRAEEAIEAIKSLrVRCSDQAQESLDNiLLDLYKRCGRLD 127
Cdd:COG2956  50 NLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKL-LELDPDDAEALRL-LAEIYEQEGDWE 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439 128 DQIGLLKHKL--------FLIQKGLAFNG-KRTKTARSQGKKFqVSVEQEATRLLGNLGWALMQRDNFVEAEDAYRRALS 198
Cdd:COG2956 128 KAIEVLERLLklgpenahAYCELAELYLEqGDYDEAIEALEKA-LKLDPDCARALLLLAELYLEQGDYEEAIAALERALE 206

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15230439 199 IAPDNNK-MCNLGICLMKQGRIDEAKETLRRV-----KPAVVDGPRGVDSHLKAYERAQQMLNDL 257
Cdd:COG2956 207 QDPDYLPaLPRLAELYEKLGDPEEALELLRKAleldpSDDLLLALADLLERKEGLEAALALLERQ 271
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 175-229 4.03e-11

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 61.13  E-value: 4.03e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15230439 175 NLGWALMQRDNFVEAEDAYRRALSIAPDNNK-MCNLGICLMKQGRIDEAKETLRRV 229
Cdd:COG5010  93 NLALLYSRSGDKDEAKEYYEKALALSPDNPNaYSNLAALLLSLGQDDEAKAALQRA 148
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
173-229 4.00e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.02  E-value: 4.00e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15230439 173 LGNLGWALMQRDNFVEAEDAYRRALSIAPDNNK-MCNLGICLMKQGRIDEAKETLRRV 229
Cdd:COG0457  11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEaLYNLGLAYLRLGRYEEALADYEQA 68
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 117-229 5.57e-10

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 57.66  E-value: 5.57e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439 117 LDLYKRCGRLDDQIGLLKHKLFLIQKGLAFNGKRTKTARSQGKKFQVSVEQEATRLLGNLGWALMQRDNFVEAEDAYRRA 196
Cdd:COG5010   1 ARALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQA 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 15230439 197 LSIAPDNNK-MCNLGICLMKQGRIDEAKETLRRV 229
Cdd:COG5010  81 LQLDPNNPElYYNLALLYSRSGDKDEAKEYYEKA 114
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 175-229 2.84e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 55.01  E-value: 2.84e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15230439 175 NLGWALMQRDNFVEAEDAYRRALSIAPDN-NKMCNLGICLMKQGRIDEAKETLRRV 229
Cdd:COG4235  22 LLGRAYLRLGRYDEALAAYEKALRLDPDNaDALLDLAEALLAAGDTEEAEELLERA 77
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 172-229 9.71e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 53.47  E-value: 9.71e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15230439 172 LLGNLGWALMQRDNFVEAEDAYRRALSIAPDNNK-MCNLGICLMKQGRIDEAKETLRRV 229
Cdd:COG4235  53 ALLDLAEALLAAGDTEEAEELLERALALDPDNPEaLYLLGLAAFQQGDYAEAIAAWQKL 111
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
171-229 1.23e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 52.09  E-value: 1.23e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439 171 RLLGNLGWALMQRDNFVEAEdAYRRALSIAPDN-NKMCNLGICLMKQGRIDEAKETLRRV 229
Cdd:COG3063  27 DALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNaEALLNLAELLLELGDYDEALAYLERA 85
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 175-229 1.54e-08

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 52.30  E-value: 1.54e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15230439 175 NLGWALMQRDNFVEAEDAYRRALSIAPDNNK----MCNLGICLMKQGRIDEAKETLRRV 229
Cdd:COG1729  35 WLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdaLLKLGLSYLELGDYDKARATLEEL 93
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 175-258 3.54e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.12  E-value: 3.54e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439 175 NLGWALMQRDNFVEAEDAYRRALSIAPDNNK-MCNLGICLMKQGRIDEAKETLRRvkpAVVDGPRgvdsHLKAYERAQQM 253
Cdd:COG4783  43 LLGEILLQLGDLDEAIVLLHEALELDPDEPEaRLNLGLALLKAGDYDEALALLEK---ALKLDPE----HPEAYLRLARA 115


                ....*
gi 15230439 254 LNDLG 258
Cdd:COG4783 116 YRALG 120
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
179-224 5.46e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 50.17  E-value: 5.46e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 15230439 179 ALMQRDNFVEAEDAYRRALSIAPDN-NKMCNLGICLMKQGRIDEAKE 224
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNaDALNNLGLLLLEQGRYDEAIA 47
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 43-257 5.91e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.58  E-value: 5.91e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439  43 YVRAKNvQLVEKDPERAIPLFWKAINAGDRVDSALKDMAIVMKQQNRAEEAIEAIKSLRVRCSDQAQesLDNILLDLYKR 122
Cdd:COG2956  12 YFKGLN-YLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAE--ALLELAQDYLK 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439 123 CGRLDDQIGLLKhklfliqKGLAFNGKRtktarsqgkkfqvsveQEATRLLGNLgwaLMQRDNFVEAEDAYRRALSIAPD 202
Cdd:COG2956  89 AGLLDRAEELLE-------KLLELDPDD----------------AEALRLLAEI---YEQEGDWEKAIEVLERLLKLGPE 142

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15230439 203 N-NKMCNLGICLMKQGRIDEAKETLRRvkpAVVDGPRGVDSHL---------KAYERAQQMLNDL 257
Cdd:COG2956 143 NaHAYCELAELYLEQGDYDEAIEALEK---ALKLDPDCARALLllaelyleqGDYEEAIAALERA 204
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 55-247 6.53e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 54.61  E-value: 6.53e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439  55 DPERAIPLFWKAINAGDRVDSALKDMAIVMKQQNRAEEAIEAIKSLRVRCSDQAqESLDNiLLDLYKRCGRLDDQIGLLk 134
Cdd:COG3914  93 RYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFA-EAYLN-LGEALRRLGRLEEAIAAL- 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439 135 hklfliQKGLAFNGKRTKtarsqgkkfqvsveqeatrLLGNLGWALMQRDNFVEAEDAYRRALSIAPDNNK-MCNLGICL 213
Cdd:COG3914 170 ------RRALELDPDNAE-------------------ALNNLGNALQDLGRLEEAIAAYRRALELDPDNADaHSNLLFAL 224

                       170       180       190
                ....*....|....*....|....*....|....
gi 15230439 214 MKQGRIDEAKETLRRVKpAVVDGPRGVDSHLKAY 247
Cdd:COG3914 225 RQACDWEVYDRFEELLA-ALARGPSELSPFALLY 257
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 167-253 3.03e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 52.69  E-value: 3.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439 167 QEATRLLGNLGWALMQRDNFVEAEDAYRRALSIAPDNNK-MCNLGICLMKQGRIDEAKETLRRvkpAVVDGPRGVDSHL- 244
Cdd:COG3914  75 LLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEaLFNLGNLLLALGRLEEALAALRR---ALALNPDFAEAYLn 151

                        90
                ....*....|.
gi 15230439 245 --KAYERAQQM 253
Cdd:COG3914 152 lgEALRRLGRL 162
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 75-228 6.00e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 48.65  E-value: 6.00e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439  75 SALKDMAIVMKQQNRAEEAIEAIKSLRVRCSD--QAQESLDNILLDLykrcGRLDDQIGLLkhklfliQKGLAFNGKrtk 152
Cdd:COG4783   5 EALYALAQALLLAGDYDEAEALLEKALELDPDnpEAFALLGEILLQL----GDLDEAIVLL-------HEALELDPD--- 70

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15230439 153 tarsqgkkfqvsvEQEAtrlLGNLGWALMQRDNFVEAEDAYRRALSIAPDN-NKMCNLGICLMKQGRIDEAKETLRR 228
Cdd:COG4783  71 -------------EPEA---RLNLGLALLKAGDYDEALALLEKALKLDPEHpEAYLRLARAYRALGRPDEAIAALEK 131
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 179-287 2.12e-06

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 49.16  E-value: 2.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439 179 ALMQRDNFVEAEDAYRRALSIAPDNNK-MCNLGICLMKQGRIDEAKETLRRvkpAV-----------------VDGPRGV 240
Cdd:cd24142   9 ELLDQGNFELALKFLQRALELEPNNVEaLELLGEILLELGDVEEAREVLLR---AIeldpdggyekylylgqlSGGEEAL 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15230439 241 DSHLKAYERAQQMLNDLGSEMMRRGGDDKVEQRRLFDAIFGSSSIWQ 287
Cdd:cd24142  86 QYYEKGIEILEEELQALQAASAEAEEEAEELKRKLSSALCALAEIYM 132
TPR_19 pfam14559
Tetratricopeptide repeat;
185-238 3.54e-06

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 44.11  E-value: 3.54e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 15230439   185 NFVEAEDAYRRALSIAPDNNKMC-NLGICLMKQGRIDEAKETLRRVKPAVVDGPR 238
Cdd:pfam14559   3 DYAEALELLEQALAEDPDNAEARlGLAEALLALGRLDEAEALLAALPAADPDDPR 57
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 176-229 3.62e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 46.34  E-value: 3.62e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15230439 176 LGWALMQRDNFVEAEDAYRRALSIAPDNNK-MCNLGICLMKQGRIDEAKETLRRV 229
Cdd:COG4783  10 LAQALLLAGDYDEAEALLEKALELDPDNPEaFALLGEILLQLGDLDEAIVLLHEA 64
TPR_1 pfam00515
Tetratricopeptide repeat;
171-203 4.07e-06

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 43.18  E-value: 4.07e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 15230439   171 RLLGNLGWALMQRDNFVEAEDAYRRALSIAPDN 203
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 48-230 5.13e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.93  E-value: 5.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439    48 NVQLVEKDPERAIPLFWKAINAGDRVDSALKDMAIVMKQQNRAEEAIEAIKSLRVRCSDQAQESLdniLLDLYKRCGRLD 127
Cdd:TIGR02917 711 DLYLRQKDYPAAIQAYRKALKRAPSSQNAIKLHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTA---LAELYLAQKDYD 787

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439   128 DQIgllKHKLFLIQK---------GLAF---NGKRTKTARSQGKKFQVSVEQEAtrLLGNLGWALMQRDNFVEAEDAYRR 195
Cdd:TIGR02917 788 KAI---KHYQTVVKKapdnavvlnNLAWlylELKDPRALEYAERALKLAPNIPA--ILDTLGWLLVEKGEADRALPLLRK 862

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 15230439   196 ALSIAPDNNKM-CNLGICLMKQGRIDEAKETLRRVK 230
Cdd:TIGR02917 863 AVNIAPEAAAIrYHLALALLATGRKAEARKELDKLL 898
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
175-277 1.13e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 46.45  E-value: 1.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439 175 NLGWALMQRDNFVEAEDAYRRALSIAPDNNK-MCNLGICLMKQGRIDEAKETLRR-VKPAVVDGPRGVDSHL----KAYE 248
Cdd:COG4785 112 NRGLAYLLLGDYDAALEDFDRALELDPDYAYaYLNRGIALYYLGRYELAIADLEKaLELDPNDPERALWLYLaerkLDPE 191

                        90       100       110
                ....*....|....*....|....*....|
gi 15230439 249 RAQQMLN-DLGSEMMRRGgdDKVEQRRLFD 277
Cdd:COG4785 192 KALALLLeDWATAYLLQG--DTEEARELFK 219
TPR_12 pfam13424
Tetratricopeptide repeat;
168-229 1.20e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 43.14  E-value: 1.20e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15230439   168 EATRLLGNLGWALMQRDNFVEAEDAYRRALSIA-----PDNNK----MCNLGICLMKQGRIDEAKETLRRV 229
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIArrllgPDHPLtattLLNLGRLYLELGRYEEALELLERA 71
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 171-203 1.83e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 41.28  E-value: 1.83e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 15230439    171 RLLGNLGWALMQRDNFVEAEDAYRRALSIAPDN 203
Cdd:smart00028   2 EALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
176-258 3.36e-05

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 45.26  E-value: 3.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439 176 LGWALMQRDNFVEAEDAYRRALSIAPDNNKMCNLGICLMKQGRIDEAKETLRRvkpaVVDGPRGVDSHLKAYER-----A 250
Cdd:COG4700 166 YARALEALGDLEAAEAELEALARRYSGPEARYRYAKFLARQGRTAEAKELLEE----ILDEAKHMPKHYRRLNRewireA 241


                ....*...
gi 15230439 251 QQMLNDLG 258
Cdd:COG4700 242 KKLLKSLR 249
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 63-228 4.58e-05

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 45.29  E-value: 4.58e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439  63 FWKAINAGDRVDSALKD-MAIVMKQQNRAEEAIEAI-KSLRvrcsdqaqESLDNILLDLYKRCgRLDDQIGLLKHklflI 140
Cdd:COG3071 181 LWKALPRAERRDPELAAaYARALIALGDHDEAERLLrEALK--------RQWDPRLVRLYGRL-QGGDPAKQLKR----A 247

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439 141 QKGLAfngKRTKTARsqgkkfqvsveqeatrLLGNLGWALMQRDNFVEAEDAYRRALSIAPDNNKMCNLGICLMKQGRID 220
Cdd:COG3071 248 EKWLK---KHPNDPD----------------LLLALGRLCLRNQLWGKAREYLEAALALRPSAEAYAELARLLEQLGDPE 308


                ....*...
gi 15230439 221 EAKETLRR 228
Cdd:COG3071 309 EAAEHYRK 316
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 171-202 4.92e-05

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 40.20  E-value: 4.92e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 15230439   171 RLLGNLGWALMQRDNFVEAEDAYRRALSIAPD 202
Cdd:pfam07719   2 EALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
175-257 2.41e-04

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 42.56  E-value: 2.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439 175 NLGWALMQRDNFVEAEDAYRRALS-IAPDNNKMCN-LGICLMKQGRIDEAKETLRRVKPAVVDGpRGVDSHLkAYERAQQ 252
Cdd:COG4700  94 RLADALLELGRYDEAIELYEEALTgIFADDPHILLgLAQALFELGRYAEALETLEKLIAKNPDF-KSSDAHL-LYARALE 171


                ....*
gi 15230439 253 MLNDL 257
Cdd:COG4700 172 ALGDL 176
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 54-226 3.98e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.76  E-value: 3.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439    54 KDPERAIPLFWKAINAGDRVDSALKDMAIVMKQQNRAEEAIEAIKSLRVRCSDQAQESLdnILLDLYKRCGRLDDQIGLL 133
Cdd:TIGR02917 581 GQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALL--LLADAYAVMKNYAKAITSL 658

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439   134 KH---------KLFLIQKGLAFNGKRTKTARSQGKKFQVSVEQEATrLLGNLGWALMQRDNFVEAEDAYRRALSIAPDNN 204
Cdd:TIGR02917 659 KRalelkpdntEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAAL-GFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQ 737

                         170       180
                  ....*....|....*....|..
gi 15230439   205 KMCNLGICLMKQGRIDEAKETL 226
Cdd:TIGR02917 738 NAIKLHRALLASGNTAEAVKTL 759
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 178-257 8.55e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 38.82  E-value: 8.55e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439 178 WALMQRDNFVEAEDAYRRALSIAPDNNKMCN----LGICLMKQGRIDEAKETLRRVKPAVVDGPRGVDSHLKA------- 246
Cdd:COG1729   1 KALLKAGDYDEAIAAFKAFLKRYPNSPLAPDalywLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDALLKLglsylel 80

                        90
                ....*....|...
gi 15230439 247 --YERAQQMLNDL 257
Cdd:COG1729  81 gdYDKARATLEEL 93
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 163-228 1.36e-03

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 40.01  E-value: 1.36e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15230439   163 VSVEQEATRLLGNLGWALMQRDNFVEAEDAYRRALSiapDNN------KMCNLGICLMKQGRIDEAKETLRR 228
Cdd:TIGR02521  92 LTLNPNNGDVLNNYGTFLCQQGKYEQAMQQFEQAIE---DPLypqparSLENAGLCALKAGDFDKAEKYLTR 160
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 170-203 5.07e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.91  E-value: 5.07e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 15230439 170 TRLLGNLGWALMQRDNFVEAEDAYRRALSIAPDN 203
Cdd:COG4235  85 PEALYLLGLAAFQQGDYAEAIAAWQKLLALLPAD 118
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 51-245 8.81e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.53  E-value: 8.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439    51 LVEKDPERAIPLFWKA-INAGDRVDSALKdMAIVMKQQNRAEEAIEAIKSLrVRCSDQAQESlDNILLDLYKRCGRLDdq 129
Cdd:TIGR02917 374 LALGDFEKAAEYLAKAtELDPENAAARTQ-LGISKLSQGDPSEAIADLETA-AQLDPELGRA-DLLLILSYLRSGQFD-- 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230439   130 igllkhklfliqKGLAfngkrtkTARSQGKKfqvsveQEATRLLGNL-GWALMQRDNFVEAEDAYRRALSIAPDNNK-MC 207
Cdd:TIGR02917 449 ------------KALA-------AAKKLEKK------QPDNASLHNLlGAIYLGKGDLAKAREAFEKALSIEPDFFPaAA 503

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 15230439   208 NLGICLMKQGRIDEAKEtlrRVKPAVVDGPRGVDSHLK 245
Cdd:TIGR02917 504 NLARIDIQEGNPDDAIQ---RFEKVLTIDPKNLRAILA 538
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 175-237 8.90e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 34.62  E-value: 8.90e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15230439   175 NLGWALMQRDNFVEAEDAYRRAL---SIAPDNNK-MCNLGICLMKQGRIDEAKETLRRVKPAVVDGP 237
Cdd:pfam13432   2 ALARAALRAGDYDDAAAALEAALarfPESPDAAAaLLLLGLAALRQGRLAEAAAAYRAALRAAPGDP 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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