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Conserved domains on  [gi|225543461|ref|NP_203752|]
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protein TANC1 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1079-1285 1.35e-52

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 187.08  E-value: 1.35e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1079 GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHL 1158
Cdd:COG0666    54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1159 STVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1238
Cdd:COG0666   134 EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 225543461 1239 HVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAMATSKPDIL 1285
Cdd:COG0666   214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAA 260
PHA03100 super family cl39094
ankyrin repeat protein; Provisional
 948-1205 3.57e-12

ankyrin repeat protein; Provisional


The actual alignment was detected with superfamily member PHA03100:

Pssm-ID: 476869 [Multi-domain]  Cd Length: 422  Bit Score: 70.46  E-value: 3.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  948 EEVVTLLLEFGACLDGTSENGMTALCYAAAAGH-----MKLVCLLTKKGVRVDHLDKKGqcalVHsalrghgdILQYLLT 1022
Cdd:PHA03100   48 IDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNG----IT--------PLLYAIS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1023 CEwspgppqpgtlrkshalqqaltaaasMGHSSVVQCLLgmekEHEVEVNgTDTLWGETALTAAA--GRGKLEVCELLLG 1100
Cdd:PHA03100  116 KK--------------------------SNSYSIVEYLL----DNGANVN-IKNSDGENLLHLYLesNKIDLKILKLLID 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1101 HGAAVSRTNRrgvpplfcaarqghwqiVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLS 1180
Cdd:PHA03100  165 KGVDINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227

                         250       260
                  ....*....|....*....|....*
gi 225543461 1181 ALSWACLKGHRAVVQYLVEEGAAID 1205
Cdd:PHA03100  228 PLHIAILNNNKEIFKLLLNNGPSIK 252
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1273-1410 1.36e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 69.64  E-value: 1.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1273 AAWAMATSKPDILIILLQKLMEE-----------GNVMYKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLN 1341
Cdd:COG3914    85 ALLLQALGRYEEALALYRRALALnpdnaealfnlGNLLLALGRLEEALAALRRALALNPDF-------------AEAYLN 151

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 225543461 1342 LSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLL 1410
Cdd:COG3914   152 LGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
NACHT super family cl26020
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
521-822 2.69e-08

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5635:

Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 59.05  E-value: 2.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  521 FVHSIAALLCRSHQLAAYR-DLLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIpeeeyIILIDGLNEAEF 599
Cdd:COG5635   196 LLRYLALELAERYLDAEDPiPILIELRDLAEEASLEDLLAEALEKRGGEPEDALERLLRNGRL-----LLLLDGLDEVPD 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  600 hkPDYGDTLSSFITKIISKFPAwLKLIVTVRANFQEIISALPFVKLSLDDFpDNKDIHSDLHAYVQHRVHSSQDILSNIS 679
Cdd:COG5635   271 --EADRDEVLNQLRRFLERYPK-ARVIITSRPEGYDSSELEGFEVLELAPL-SDEQIEEFLKKWFEATERKAERLLEALE 346

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  680 LNGKadatligkvsshlvLRSL-GSYLYLKLTLDLFQRGHlviksasykVVPVSLSELYLLQCNMkFMTQSAFERALPIL 758
Cdd:COG5635   347 ENPE--------------LRELaRNPLLLTLLALLLRERG---------ELPDTRAELYEQFVEL-LLERWDEQRGLTIY 402

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  759 N-------------VALASLH----PMTDEQIFQAINAgHIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWL 821
Cdd:COG5635   403 RelsreelrellseLALAMQEngrtEFAREELEEILRE-YLGRRKDAEALLDELLLRTGLLVERGEGRYSFAHRSFQEYL 481


                  .
gi 225543461  822 V 822
Cdd:COG5635   482 A 482
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1079-1285 1.35e-52

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 187.08  E-value: 1.35e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1079 GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHL 1158
Cdd:COG0666    54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1159 STVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1238
Cdd:COG0666   134 EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 225543461 1239 HVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAMATSKPDIL 1285
Cdd:COG0666   214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAA 260
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1116-1208 1.78e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 93.26  E-value: 1.78e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  1116 LFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAAlsSLDKEGLSALSWACLKGHRAVVQ 1195
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 225543461  1196 YLVEEGAAIDQTD 1208
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1092-1268 3.57e-22

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 101.67  E-value: 3.57e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1092 LEVCELLLGHGAAVSRTNRRGVPPLFCAA--RQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAA--CEGHLSTVEFLLSK 1167
Cdd:PHA03100   86 KEIVKLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLesNKIDLKILKLLIDK 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1168 GAALSSLDKeglsalswaclkghravVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRP 1247
Cdd:PHA03100  166 GVDINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTP 228

                         170       180
                  ....*....|....*....|.
gi 225543461 1248 LDRAIGCRNTSVVVALLRKGA 1268
Cdd:PHA03100  229 LHIAILNNNKEIFKLLLNNGP 249
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 948-1205 3.57e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 70.46  E-value: 3.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  948 EEVVTLLLEFGACLDGTSENGMTALCYAAAAGH-----MKLVCLLTKKGVRVDHLDKKGqcalVHsalrghgdILQYLLT 1022
Cdd:PHA03100   48 IDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNG----IT--------PLLYAIS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1023 CEwspgppqpgtlrkshalqqaltaaasMGHSSVVQCLLgmekEHEVEVNgTDTLWGETALTAAA--GRGKLEVCELLLG 1100
Cdd:PHA03100  116 KK--------------------------SNSYSIVEYLL----DNGANVN-IKNSDGENLLHLYLesNKIDLKILKLLID 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1101 HGAAVSRTNRrgvpplfcaarqghwqiVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLS 1180
Cdd:PHA03100  165 KGVDINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227

                         250       260
                  ....*....|....*....|....*
gi 225543461 1181 ALSWACLKGHRAVVQYLVEEGAAID 1205
Cdd:PHA03100  228 PLHIAILNNNKEIFKLLLNNGPSIK 252
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1273-1410 1.36e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 69.64  E-value: 1.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1273 AAWAMATSKPDILIILLQKLMEE-----------GNVMYKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLN 1341
Cdd:COG3914    85 ALLLQALGRYEEALALYRRALALnpdnaealfnlGNLLLALGRLEEALAALRRALALNPDF-------------AEAYLN 151

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 225543461 1342 LSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLL 1410
Cdd:COG3914   152 LGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
Ank_2 pfam12796
Ankyrin repeats (3 copies);
946-1021 9.27e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.13  E-value: 9.27e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 225543461   946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLV-CLLTKKGVRVDHldkKGQCALVHSALRGHGDILQYLL 1021
Cdd:pfam12796    8 GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVkLLLEHADVNLKD---NGRTALHYAARSGHLEIVKLLL 81
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
521-822 2.69e-08

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 59.05  E-value: 2.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  521 FVHSIAALLCRSHQLAAYR-DLLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIpeeeyIILIDGLNEAEF 599
Cdd:COG5635   196 LLRYLALELAERYLDAEDPiPILIELRDLAEEASLEDLLAEALEKRGGEPEDALERLLRNGRL-----LLLLDGLDEVPD 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  600 hkPDYGDTLSSFITKIISKFPAwLKLIVTVRANFQEIISALPFVKLSLDDFpDNKDIHSDLHAYVQHRVHSSQDILSNIS 679
Cdd:COG5635   271 --EADRDEVLNQLRRFLERYPK-ARVIITSRPEGYDSSELEGFEVLELAPL-SDEQIEEFLKKWFEATERKAERLLEALE 346

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  680 LNGKadatligkvsshlvLRSL-GSYLYLKLTLDLFQRGHlviksasykVVPVSLSELYLLQCNMkFMTQSAFERALPIL 758
Cdd:COG5635   347 ENPE--------------LRELaRNPLLLTLLALLLRERG---------ELPDTRAELYEQFVEL-LLERWDEQRGLTIY 402

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  759 N-------------VALASLH----PMTDEQIFQAINAgHIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWL 821
Cdd:COG5635   403 RelsreelrellseLALAMQEngrtEFAREELEEILRE-YLGRRKDAEALLDELLLRTGLLVERGEGRYSFAHRSFQEYL 481


                  .
gi 225543461  822 V 822
Cdd:COG5635   482 A 482
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1079-1198 8.55e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 53.86  E-value: 8.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1079 GETALTAAAGRGKLEVCELLLGHGAAVS---------RTNRR-----GVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQ 1144
Cdd:cd22192    89 GETALHIAVVNQNLNLVRELIARGADVVspratgtffRPGPKnliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSL 168

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225543461 1145 GRTPLMV--------AACEghlsTVEFLLS--KGAALSSLD----KEGLSALSWACLKGHRAVVQYLV 1198
Cdd:cd22192   169 GNTVLHIlvlqpnktFACQ----MYDLILSydKEDDLQPLDlvpnNQGLTPFKLAAKEGNIVMFQHLV 232
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1144-1169 3.57e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 3.57e-04
                            10        20
                    ....*....|....*....|....*.
gi 225543461   1144 QGRTPLMVAACEGHLSTVEFLLSKGA 1169
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGA 26
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1079-1290 5.87e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 44.69  E-value: 5.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  1079 GETALTAAAgRGKLEVCELLLGHGAAVSR------------TNR--RGVPPLFCAARQGHWQIVRLLLERGCDVNL---- 1140
Cdd:TIGR00870   82 GDTLLHAIS-LEYVDAVEAILLHLLAAFRksgplelandqyTSEftPGITALHLAAHRQNYEIVKLLLERGASVPAracg 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  1141 -----SDKQ-----GRTPLMVAACEGHLSTVEFLLSKGAALSSLDKeglsaLSWACLkgHRAVVQ--------------- 1195
Cdd:TIGR00870  161 dffvkSQGVdsfyhGESPLNAAACLGSPSIVALLSEDPADILTADS-----LGNTLL--HLLVMEnefkaeyeelscqmy 233

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  1196 -YLVEEGAAIDQTDK-------NGRTPLDLAAFYGDAETVLYLVE-KGAVIEHVDH------SGMRPLDRAIGCRNTSVV 1260
Cdd:TIGR00870  234 nFALSLLDKLRDSKElevilnhQGLTPLKLAAKEGRIVLFRLKLAiKYKQKKFVAWpngqqlLSLYWLEELDGWRRKQSV 313

                          250       260       270
                   ....*....|....*....|....*....|
gi 225543461  1261 VALLrkgaklgnAAWAMATSKPDILIILLQ 1290
Cdd:TIGR00870  314 LELI--------VVFVIGLKFPELSDMYLI 335
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1300-1412 1.37e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.53  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  1300 YKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARA 1379
Cdd:TIGR02917  510 IQEGNPDDAIQRFEKVLTIDPKN-------------LRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQY 576

                           90       100       110
                   ....*....|....*....|....*....|...
gi 225543461  1380 KRNSRQFVAALADLQEAVKLCPTNQEVKRLLAR 1412
Cdd:TIGR02917  577 YLGKGQLKKALAILNEAADAAPDSPEAWLMLGR 609
TPR_14 pfam13428
Tetratricopeptide repeat;
1371-1413 2.65e-03

Tetratricopeptide repeat;


Pssm-ID: 463874 [Multi-domain]  Cd Length: 44  Bit Score: 37.40  E-value: 2.65e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 225543461  1371 EAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARV 1413
Cdd:pfam13428    2 EALLALARALLALGDPDEALALLERALALDPDDPEAWLALAQL 44
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1079-1285 1.35e-52

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 187.08  E-value: 1.35e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1079 GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHL 1158
Cdd:COG0666    54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1159 STVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1238
Cdd:COG0666   134 EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 225543461 1239 HVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAMATSKPDIL 1285
Cdd:COG0666   214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAA 260
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1072-1274 2.55e-51

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 183.62  E-value: 2.55e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1072 NGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1151
Cdd:COG0666    80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1152 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLV 1231
Cdd:COG0666   160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 225543461 1232 EKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAA 1274
Cdd:COG0666   240 EAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
933-1248 6.31e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 167.82  E-value: 6.31e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  933 LNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRG 1012
Cdd:COG0666    19 LLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1013 HGDILQYLLtcewspgppqpgtlrkshalqqaltaaasmghssvvqcllgmekEHEVEVNGTDTlWGETALTAAAGRGKL 1092
Cdd:COG0666    99 DLEIVKLLL--------------------------------------------EAGADVNARDK-DGETPLHLAAYNGNL 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1093 EVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALS 1172
Cdd:COG0666   134 EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225543461 1173 SLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1248
Cdd:COG0666   214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
900-1215 9.33e-42

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 155.88  E-value: 9.33e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  900 AALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAG 979
Cdd:COG0666    19 LLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  980 HMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLtcewspgppqpgtlrkshalqqaltaaasmghssvvqc 1059
Cdd:COG0666    99 DLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL-------------------------------------- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1060 llgmekEHEVEVNGTDTlWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1139
Cdd:COG0666   141 ------EAGADVNAQDN-DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225543461 1140 LSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPL 1215
Cdd:COG0666   214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1060-1318 3.15e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 154.34  E-value: 3.15e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1060 LLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1139
Cdd:COG0666     2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1140 LSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAA 1219
Cdd:COG0666    82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1220 FYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA------KLGNAA--WAMATSKPDILIILLQK 1291
Cdd:COG0666   162 ANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAdvnakdNDGKTAldLAAENGNLEIVKLLLEA 241

                         250       260
                  ....*....|....*....|....*..
gi 225543461 1292 LMEEGNVMYKKGKMKEAAQRYQYALRK 1318
Cdd:COG0666   242 GADLNAKDKDGLTALLLAAAAGAALIV 268
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1116-1208 1.78e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 93.26  E-value: 1.78e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  1116 LFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAAlsSLDKEGLSALSWACLKGHRAVVQ 1195
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 225543461  1196 YLVEEGAAIDQTD 1208
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1092-1268 3.57e-22

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 101.67  E-value: 3.57e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1092 LEVCELLLGHGAAVSRTNRRGVPPLFCAA--RQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAA--CEGHLSTVEFLLSK 1167
Cdd:PHA03100   86 KEIVKLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLesNKIDLKILKLLIDK 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1168 GAALSSLDKeglsalswaclkghravVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRP 1247
Cdd:PHA03100  166 GVDINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTP 228

                         170       180
                  ....*....|....*....|.
gi 225543461 1248 LDRAIGCRNTSVVVALLRKGA 1268
Cdd:PHA03100  229 LHIAILNNNKEIFKLLLNNGP 249
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1149-1241 6.43e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 89.02  E-value: 6.43e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  1149 LMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEgAAIDQTDkNGRTPLDLAAFYGDAETVL 1228
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 225543461  1229 YLVEKGAVIEHVD 1241
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1083-1169 5.86e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.32  E-value: 5.86e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  1083 LTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERgCDVNLSDkQGRTPLMVAACEGHLSTVE 1162
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78


                   ....*..
gi 225543461  1163 FLLSKGA 1169
Cdd:pfam12796   79 LLLEKGA 85
PHA03095 PHA03095
ankyrin-like protein; Provisional
 906-1218 9.21e-20

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 94.71  E-value: 9.21e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  906 RNLYTPNVKVS--RLLILGGANVNYRTEvLNNAPiLCVQSHLGHE---EVVTLLLEFGACLDGTSENGMTAL-CYAAAAG 979
Cdd:PHA03095   18 YLLNASNVTVEevRRLLAAGADVNFRGE-YGKTP-LHLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLhLYLYNAT 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  980 HMKLVCLLTKKGVRVDHLDKKGQCALvHSALRG---HGDILQYLLtcewspgppqpgtlrkshalqqaltaaasmghssv 1056
Cdd:PHA03095   96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLL----------------------------------- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1057 vqcllgmekEHEVEVNGTDtLWGETALTA--AAGRGKLEVCELLLGHGAAVSRTNRRGVPPL-----FCAARQGhwqIVR 1129
Cdd:PHA03095  140 ---------RKGADVNALD-LYGMTPLAVllKSRNANVELLRLLIDAGADVYAVDDRFRSLLhhhlqSFKPRAR---IVR 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1130 LLLERGCDVNLSDKQGRTPLMVAA--CEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQT 1207
Cdd:PHA03095  207 ELIRAGCDPAATDMLGNTPLHSMAtgSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAV 286

                         330
                  ....*....|.
gi 225543461 1208 DKNGRTPLDLA 1218
Cdd:PHA03095  287 SSDGNTPLSLM 297
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 958-1274 1.11e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 88.10  E-value: 1.11e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  958 GACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGP-PQPGTlr 1036
Cdd:PHA02874   25 GNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSIlPIPCI-- 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1037 kshalqqaltaaasmgHSSVVQCLLgmekEHEVEVNGTDTLwGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPL 1116
Cdd:PHA02874  103 ----------------EKDMIKTIL----DCGIDVNIKDAE-LKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1117 FCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKgHRAVVQY 1196
Cdd:PHA02874  162 HIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIH-NRSAIEL 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 225543461 1197 LVEEgAAIDQTDKNGRTPLDLAAFYG-DAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAA 1274
Cdd:PHA02874  241 LINN-ASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDPVIKDIIANAVLIKEA 318
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1052-1142 9.05e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.38  E-value: 9.05e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  1052 GHSSVVQCLLgmekEHEVEVNGTDTlWGETALTAAAGRGKLEVCELLLGHGAAVSRTNrrGVPPLFCAARQGHWQIVRLL 1131
Cdd:pfam12796    8 GNLELVKLLL----ENGADANLQDK-NGRTALHLAAKNGHLEIVKLLLEHADVNLKDN--GRTALHYAARSGHLEIVKLL 80

                           90
                   ....*....|.
gi 225543461  1132 LERGCDVNLSD 1142
Cdd:pfam12796   81 LEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1092-1270 1.25e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 78.53  E-value: 1.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1092 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGH-WQIVRLLLERGCDVNLSDKQGRTPLMVAAC--EGHLSTVEFLLSKG 1168
Cdd:PHA03095   63 KDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfNINPKVIRLLLRKG 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1169 AALSSLDKEGLSALSwACLKGHRA---VVQYLVEEGAAIDQTDKNGRTPLD--LAAFYGDAETVLYLVEKGAVIEHVDHS 1243
Cdd:PHA03095  143 ADVNALDLYGMTPLA-VLLKSRNAnveLLRLLIDAGADVYAVDDRFRSLLHhhLQSFKPRARIVRELIRAGCDPAATDML 221

                         170       180       190
                  ....*....|....*....|....*....|
gi 225543461 1244 GMRPLDRAI---GCRNtSVVVALLRKGAKL 1270
Cdd:PHA03095  222 GNTPLHSMAtgsSCKR-SLVLPLLIAGISI 250
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1182-1270 1.51e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.92  E-value: 1.51e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  1182 LSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVieHVDHSGMRPLDRAIGCRNTSVVV 1261
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78


                   ....*....
gi 225543461  1262 ALLRKGAKL 1270
Cdd:pfam12796   79 LLLEKGADI 87
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1127-1270 1.88e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 78.14  E-value: 1.88e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1127 IVRLLLERGCDVNLSDKQGRTPL---MVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL-SWACLKGHRAVVQYLVEEGA 1202
Cdd:PHA03095   29 EVRRLLAAGADVNFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGA 108

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225543461 1203 AIDQTDKNGRTPLD--LAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSV--VVALLRKGAKL 1270
Cdd:PHA03095  109 DVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANVelLRLLIDAGADV 180
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 948-1205 3.57e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 70.46  E-value: 3.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  948 EEVVTLLLEFGACLDGTSENGMTALCYAAAAGH-----MKLVCLLTKKGVRVDHLDKKGqcalVHsalrghgdILQYLLT 1022
Cdd:PHA03100   48 IDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNG----IT--------PLLYAIS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1023 CEwspgppqpgtlrkshalqqaltaaasMGHSSVVQCLLgmekEHEVEVNgTDTLWGETALTAAA--GRGKLEVCELLLG 1100
Cdd:PHA03100  116 KK--------------------------SNSYSIVEYLL----DNGANVN-IKNSDGENLLHLYLesNKIDLKILKLLID 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1101 HGAAVSRTNRrgvpplfcaarqghwqiVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLS 1180
Cdd:PHA03100  165 KGVDINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227

                         250       260
                  ....*....|....*....|....*
gi 225543461 1181 ALSWACLKGHRAVVQYLVEEGAAID 1205
Cdd:PHA03100  228 PLHIAILNNNKEIFKLLLNNGPSIK 252
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1273-1410 1.36e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 69.64  E-value: 1.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1273 AAWAMATSKPDILIILLQKLMEE-----------GNVMYKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLN 1341
Cdd:COG3914    85 ALLLQALGRYEEALALYRRALALnpdnaealfnlGNLLLALGRLEEALAALRRALALNPDF-------------AEAYLN 151

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 225543461 1342 LSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLL 1410
Cdd:COG3914   152 LGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1126-1275 2.17e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 68.37  E-value: 2.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1126 QIVRLLLERGCDVNLSDK-QGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAI 1204
Cdd:PHA02878  148 EITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 225543461 1205 DQTDKNGRTPLDLAAFY-GDAETVLYLVEKGAVIEHVDH-SGMRPLDRAIgcRNTSVVVALLRKGAKLGNAAW 1275
Cdd:PHA02878  228 DARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI--KSERKLKLLLEYGADINSLNS 298
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1296-1413 2.67e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.80  E-value: 2.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1296 GNVMYKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYA 1375
Cdd:COG0457    15 GLAYRRLGRYEEAIEDYEKALELDPDD-------------AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 225543461 1376 RARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARV 1413
Cdd:COG0457    82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLA 119
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1296-1416 2.99e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.80  E-value: 2.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1296 GNVMYKKGKMKEAAQRYQYALRKFPRegfgedmrpfnelRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYA 1375
Cdd:COG0457    49 GLAYLRLGRYEEALADYEQALELDPD-------------DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 225543461 1376 RARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEE 1416
Cdd:COG0457   116 LGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEK 156
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1264-1403 4.30e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 62.52  E-value: 4.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1264 LRKGAKLGNAAWAMATSKPDILIILlqklmeeGNVMYKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLNLS 1343
Cdd:COG4783    20 YDEAEALLEKALELDPDNPEAFALL-------GEILLQLGDLDEAIVLLHEALELDPDE-------------PEARLNLG 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1344 RCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTN 1403
Cdd:COG4783    80 LALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 854-1270 7.65e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 67.40  E-value: 7.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  854 LNRQQTMELGHHILKAhifkglskktGISSSHLQALWIGYSTEGLSAALASLRNlytPNVKVSRLLILGGANVNYRtEVL 933
Cdd:PHA02876  112 LNKHKLDEACIHILKE----------AISGNDIHYDKINESIEYMKLIKERIQQ---DELLIAEMLLEGGADVNAK-DIY 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  934 NNAPILCVQSHlGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGH 1013
Cdd:PHA02876  178 CITPIHYAAER-GNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDLSLLKAIRNEDLETS 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1014 ------GDILQYLLTCEWSPgppqpgtlrkshalqqALTAAASMGHSSVVQCLLgmekEHEVEVNGTDtLWGETALTAAA 1087
Cdd:PHA02876  257 lllydaGFSVNSIDDCKNTP----------------LHHASQAPSLSRLVPKLL----ERGADVNAKN-IKGETPLYLMA 315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1088 GRG-KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQ-IVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLL 1165
Cdd:PHA02876  316 KNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLDRNKdIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLL 395

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1166 SKGAALSSLDKEGLSALSWA-CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYG-DAETVLYLVEKGAVIEHVDHS 1243
Cdd:PHA02876  396 DYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQ 475

                         410       420
                  ....*....|....*....|....*..
gi 225543461 1244 GMRPLDRAIGCRntSVVVALLRKGAKL 1270
Cdd:PHA02876  476 NQYPLLIALEYH--GIVNILLHYGAEL 500
Ank_2 pfam12796
Ankyrin repeats (3 copies);
946-1021 9.27e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.13  E-value: 9.27e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 225543461   946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLV-CLLTKKGVRVDHldkKGQCALVHSALRGHGDILQYLL 1021
Cdd:pfam12796    8 GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVkLLLEHADVNLKD---NGRTALHYAARSGHLEIVKLLL 81
Ank_2 pfam12796
Ankyrin repeats (3 copies);
972-1109 1.07e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 59.74  E-value: 1.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461   972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTcewspgppqpgtlrkshalqqaltaaasm 1051
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE----------------------------- 51

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 225543461  1052 ghssvvqcllgmekehevEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTN 1109
Cdd:pfam12796   52 ------------------HADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1289-1416 1.90e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 60.59  E-value: 1.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1289 LQKLMEEGNVMYKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLNLSRCRRKTNDFGMAEEFASKALELKPK 1368
Cdd:COG4783     4 AEALYALAQALLLAGDYDEAEALLEKALELDPDN-------------PEAFALLGEILLQLGDLDEAIVLLHEALELDPD 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 225543461 1369 SYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEE 1416
Cdd:COG4783    71 EPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRA 118
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
1298-1405 2.16e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 59.03  E-value: 2.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1298 VMYKKGKMKEAAQRYQYALRKFPREGfgedmrpfnelrvSLYLNLSRCRRKTNDFGMAEEFaSKALELKPKSYEAFYARA 1377
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNA-------------DALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLA 66

                          90       100
                  ....*....|....*....|....*...
gi 225543461 1378 RAKRNSRQFVAALADLQEAVKLCPTNQE 1405
Cdd:COG3063    67 ELLLELGDYDEALAYLERALELDPSALR 94
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1296-1415 2.33e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 60.02  E-value: 2.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1296 GNVMYKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYA 1375
Cdd:COG4235    24 GRAYLRLGRYDEALAAYEKALRLDPDN-------------ADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYL 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 225543461 1376 RARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEE 1415
Cdd:COG4235    91 LGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEASIAE 130
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1307-1416 2.72e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 60.02  E-value: 2.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1307 EAAQRYQYALRKFPREGFGedmrpfnelrvslYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQF 1386
Cdd:COG4235     1 EAIARLRQALAANPNDAEG-------------WLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDT 67

                          90       100       110
                  ....*....|....*....|....*....|
gi 225543461 1387 VAALADLQEAVKLCPTNQEVKRLLARVEEE 1416
Cdd:COG4235    68 EEAEELLERALALDPDNPEALYLLGLAAFQ 97
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1285-1413 8.20e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.86  E-value: 8.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1285 LIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLNLSRCRRKTNDFGMAEEFASKALE 1364
Cdd:COG3914    74 LLLLAALLELAALLLQALGRYEEALALYRRALALNPDN-------------AEALFNLGNLLLALGRLEEALAALRRALA 140

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 225543461 1365 LKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARV 1413
Cdd:COG3914   141 LNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNA 189
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1083-1249 1.30e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 63.35  E-value: 1.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1083 LTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHlSTVE 1162
Cdd:PLN03192  529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKH-HKIF 607

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1163 FLLSKGAALSSLDKEGlSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVD- 1241
Cdd:PLN03192  608 RILYHFASISDPHAAG-DLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANt 686


                  ....*...
gi 225543461 1242 HSGMRPLD 1249
Cdd:PLN03192  687 DDDFSPTE 694
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1260-1405 1.34e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 60.31  E-value: 1.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1260 VVALLRKGAKLGNAAWAMATSKPDiliiLLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFPRegfgedmrpfnelRVSLY 1339
Cdd:COG4785    48 LAAAALAAAALAAERIDRALALPD----LAQLYYERGVAYDSLGDYDLAIADFDQALELDPD-------------LAEAY 110

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225543461 1340 LNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQE 1405
Cdd:COG4785   111 NNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPE 176
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1305-1413 1.53e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 58.43  E-value: 1.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1305 MKEAAQRYQYALRKFPREGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSR 1384
Cdd:COG5010    23 LVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSG 102

                          90       100
                  ....*....|....*....|....*....
gi 225543461 1385 QFVAALADLQEAVKLCPTNQEVKRLLARV 1413
Cdd:COG5010   103 DKDEAKEYYEKALALSPDNPNAYSNLAAL 131
Ank_4 pfam13637
Ankyrin repeats (many copies);
1112-1165 2.69e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.59  E-value: 2.69e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 225543461  1112 GVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLL 1165
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1262-1401 2.72e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 57.66  E-value: 2.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1262 ALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFPREGfgedmrpfnelrvSLYLN 1341
Cdd:COG5010    27 YEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNP-------------ELYYN 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1342 LSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCP 1401
Cdd:COG5010    94 LALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
Ank_4 pfam13637
Ankyrin repeats (many copies);
1081-1132 3.06e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.59  E-value: 3.06e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 225543461  1081 TALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLL 1132
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
1178-1231 3.37e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.20  E-value: 3.37e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 225543461  1178 GLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLV 1231
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1080-1211 3.80e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 61.16  E-value: 3.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1080 ETALTAAAGRGKLEVCELLLGHGAAVSRT-NRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHL 1158
Cdd:PHA02875   69 ESELHDAVEEGDVKAVEELLDLGKFADDVfYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 225543461 1159 STVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1211
Cdd:PHA02875  149 KGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNG 201
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1128-1197 6.80e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 60.68  E-value: 6.80e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1128 VRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYL 1197
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1286-1416 7.54e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 58.97  E-value: 7.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1286 IILLQKLMEE-----------GNVMYKKGKMKEAAQRYQYALrkfpregfgeDMRPFNElrvSLYLNLSRCRRKTNDFGM 1354
Cdd:COG2956    62 IRIHQKLLERdpdraeallelAQDYLKAGLLDRAEELLEKLL----------ELDPDDA---EALRLLAEIYEQEGDWEK 128

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225543461 1355 AEEFASKALELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEE 1416
Cdd:COG2956   129 AIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLE 190
PHA03095 PHA03095
ankyrin-like protein; Provisional
 892-1158 9.42e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 60.04  E-value: 9.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  892 GYSTEGLSAALASLRNLYTpnVKVSRLLILGGANVNYRTEVLNNApilcVQSHLG----HEEVVTLLLEFGACLDGTSEN 967
Cdd:PHA03095   78 APERCGFTPLHLYLYNATT--LDVIKLLIKAGADVNAKDKVGRTP----LHVYLSgfniNPKVIRLLLRKGADVNALDLY 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  968 GMTAL-CYAAAAG-HMKLVCLLTKKGVRVDHLDKKGQCALVHsalrghgdILQYlltcewspgppqpgtLRKShalqqal 1045
Cdd:PHA03095  152 GMTPLaVLLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLHH--------HLQS---------------FKPR------- 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1046 taaasmghSSVVQCLLgmekEHEVEVNGTDTLwGETALTAAA--GRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQG 1123
Cdd:PHA03095  202 --------ARIVRELI----RAGCDPAATDML-GNTPLHSMAtgSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFN 268

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 225543461 1124 HWQIVRLLLERGCDVNLSDKQGRTPL--MVAACEGHL 1158
Cdd:PHA03095  269 NPRACRRLIALGADINAVSSDGNTPLslMVRNNNGRA 305
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
521-822 2.69e-08

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 59.05  E-value: 2.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  521 FVHSIAALLCRSHQLAAYR-DLLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIpeeeyIILIDGLNEAEF 599
Cdd:COG5635   196 LLRYLALELAERYLDAEDPiPILIELRDLAEEASLEDLLAEALEKRGGEPEDALERLLRNGRL-----LLLLDGLDEVPD 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  600 hkPDYGDTLSSFITKIISKFPAwLKLIVTVRANFQEIISALPFVKLSLDDFpDNKDIHSDLHAYVQHRVHSSQDILSNIS 679
Cdd:COG5635   271 --EADRDEVLNQLRRFLERYPK-ARVIITSRPEGYDSSELEGFEVLELAPL-SDEQIEEFLKKWFEATERKAERLLEALE 346

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  680 LNGKadatligkvsshlvLRSL-GSYLYLKLTLDLFQRGHlviksasykVVPVSLSELYLLQCNMkFMTQSAFERALPIL 758
Cdd:COG5635   347 ENPE--------------LRELaRNPLLLTLLALLLRERG---------ELPDTRAELYEQFVEL-LLERWDEQRGLTIY 402

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  759 N-------------VALASLH----PMTDEQIFQAINAgHIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWL 821
Cdd:COG5635   403 RelsreelrellseLALAMQEngrtEFAREELEEILRE-YLGRRKDAEALLDELLLRTGLLVERGEGRYSFAHRSFQEYL 481


                  .
gi 225543461  822 V 822
Cdd:COG5635   482 A 482
Ank_2 pfam12796
Ankyrin repeats (3 copies);
917-998 3.29e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.81  E-value: 3.29e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461   917 RLLILGGANVNYRTEVLNNAPILCVQShlGHEEVVTLLLEFgACLDGTsENGMTALCYAAAAGHMKLVCLLTKKGVRVDH 996
Cdd:pfam12796   14 KLLLENGADANLQDKNGRTALHLAAKN--GHLEIVKLLLEH-ADVNLK-DNGRTALHYAARSGHLEIVKLLLEKGADINV 89


                   ..
gi 225543461   997 LD 998
Cdd:pfam12796   90 KD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1066-1218 3.51e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 58.35  E-value: 3.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQG 1145
Cdd:PHA02878  155 SYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCG 234

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 225543461 1146 RTPLMVAAceGHL---STVEFLLSKGA---ALSSLdkEGLSALSWAcLKGHRaVVQYLVEEGAAIDQTDKNGRTPLDLA 1218
Cdd:PHA02878  235 NTPLHISV--GYCkdyDILKLLLEHGVdvnAKSYI--LGLTALHSS-IKSER-KLKLLLEYGADINSLNSYKLTPLSSA 307
Ank_4 pfam13637
Ankyrin repeats (many copies);
968-1021 3.86e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.12  E-value: 3.86e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 225543461   968 GMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLL 1021
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
937-987 4.26e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.12  E-value: 4.26e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 225543461   937 PILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLL 987
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
1145-1198 4.38e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.12  E-value: 4.38e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 225543461  1145 GRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLV 1198
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1296-1396 6.39e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 55.78  E-value: 6.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1296 GNVMYKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYA 1375
Cdd:COG0457    83 GLALQALGRYEEALEDYDKALELDPDD-------------AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYN 149

                          90       100
                  ....*....|....*....|.
gi 225543461 1376 RARAKRNSRQFVAALADLQEA 1396
Cdd:COG0457   150 LGIALEKLGRYEEALELLEKL 170
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1079-1268 7.04e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 56.92  E-value: 7.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1079 GETALTAAAGRGKLEVCELLLGHGAaVSRTNRRGV-PPLFCAARQGHWQIVRLLLERGCDVN-LSDKQGRTPLMVAACEG 1156
Cdd:PHA02875   35 GISPIKLAMKFRDSEAIKLLMKHGA-IPDVKYPDIeSELHDAVEEGDVKAVEELLDLGKFADdVFYKDGMTPLHLATILK 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1157 HLSTVEFLLSKGA--ALSSLDKegLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKG 1234
Cdd:PHA02875  114 KLDIMKLLIARGAdpDIPNTDK--FSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSG 191

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 225543461 1235 AVIEHVDHSG-MRPLDRAIGCRNTSVVVALLRKGA 1268
Cdd:PHA02875  192 ANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGA 226
Ank_5 pfam13857
Ankyrin repeats (many copies);
1164-1218 9.72e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 50.42  E-value: 9.72e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 225543461  1164 LLSKG-AALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLA 1218
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1296-1416 1.26e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.12  E-value: 1.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1296 GNVMYKKGKMKEAAQRYQYALRKfpregfgedmrpfNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYA 1375
Cdd:COG2956    49 GNLYRRRGEYDRAIRIHQKLLER-------------DPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRL 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 225543461 1376 RARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEE 1416
Cdd:COG2956   116 LAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLE 156
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1050-1217 1.32e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 56.80  E-value: 1.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1050 SMGHSSVVQCLLGMEKEHEVevngTDTLwGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVR 1129
Cdd:PLN03192  534 STGNAALLEELLKAKLDPDI----GDSK-GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFR 608

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1130 LLLERGcdvNLSDKQ-GRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTD 1208
Cdd:PLN03192  609 ILYHFA---SISDPHaAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAN 685

                         170
                  ....*....|
gi 225543461 1209 -KNGRTPLDL 1217
Cdd:PLN03192  686 tDDDFSPTEL 695
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1339-1413 1.42e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 54.63  E-value: 1.42e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 225543461 1339 YLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARV 1413
Cdd:COG0457    11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLA 85
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1335-1413 3.35e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 51.35  E-value: 3.35e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 225543461 1335 RVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARV 1413
Cdd:COG4783     3 CAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLA 81
Ank_5 pfam13857
Ankyrin repeats (many copies);
1097-1152 4.62e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 48.50  E-value: 4.62e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 225543461  1097 LLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVA 1152
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1092-1178 4.68e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.90  E-value: 4.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1092 LEVCEL-----------LLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLST 1160
Cdd:PTZ00322   84 VELCQLaasgdavgariLLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREV 163

                          90
                  ....*....|....*...
gi 225543461 1161 VEFLLSKGAALSSLDKEG 1178
Cdd:PTZ00322  164 VQLLSRHSQCHFELGANA 181
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
1345-1416 7.41e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.01  E-value: 7.41e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225543461 1345 CRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQFVAALAdLQEAVKLCPTNQEVKRLLARVEEE 1416
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLE 71
Ank_4 pfam13637
Ankyrin repeats (many copies);
1211-1264 8.38e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.65  E-value: 8.38e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 225543461  1211 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALL 1264
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1079-1198 8.55e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 53.86  E-value: 8.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1079 GETALTAAAGRGKLEVCELLLGHGAAVS---------RTNRR-----GVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQ 1144
Cdd:cd22192    89 GETALHIAVVNQNLNLVRELIARGADVVspratgtffRPGPKnliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSL 168

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225543461 1145 GRTPLMV--------AACEghlsTVEFLLS--KGAALSSLD----KEGLSALSWACLKGHRAVVQYLV 1198
Cdd:cd22192   169 GNTVLHIlvlqpnktFACQ----MYDLILSydKEDDLQPLDlvpnNQGLTPFKLAAKEGNIVMFQHLV 232
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 910-1140 9.21e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.46  E-value: 9.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  910 TPNVKVSRLLILGGANVNYrtEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTK 989
Cdd:PHA02875   12 FGELDIARRLLDIGINPNF--EIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLD 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  990 KGVRVDH-LDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQaltaaasMGHSSVVQCLLgmekEHE 1068
Cdd:PHA02875   90 LGKFADDvFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVM-------MGDIKGIELLI----DHK 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 225543461 1069 VEVNGTDTlWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW-QIVRLLLERGCDVNL 1140
Cdd:PHA02875  159 ACLDIEDC-CGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKiDIVRLFIKRGADCNI 230
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1116-1268 9.25e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 54.10  E-value: 9.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1116 LFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQ 1195
Cdd:PLN03192  529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFR 608

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 225543461 1196 YLVEEGAAIDQtdKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
Cdd:PLN03192  609 ILYHFASISDP--HAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGA 679
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1149-1230 1.02e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 53.75  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1149 LMVAACE----GHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDA 1224
Cdd:PTZ00322   82 LTVELCQlaasGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFR 161


                  ....*.
gi 225543461 1225 ETVLYL 1230
Cdd:PTZ00322  162 EVVQLL 167
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 1300-1415 1.07e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 49.22  E-value: 1.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1300 YKKGKMKEAAQRYQYALRKFPRegfgedmrpfNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSY---EAFYAR 1376
Cdd:COG1729     4 LKAGDYDEAIAAFKAFLKRYPN----------SPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPkapDALLKL 73

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 225543461 1377 ARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEE 1415
Cdd:COG1729    74 GLSYLELGDYDKARATLEELIKKYPDSEAAKEARARLAR 112
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 1296-1381 2.06e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 48.45  E-value: 2.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1296 GNVMYKKGKMKEAAQRYQYALRKFPREGFGEDMrpfnelrvslYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYA 1375
Cdd:COG1729    37 GEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDA----------LLKLGLSYLELGDYDKARATLEELIKKYPDSEAAKEA 106


                  ....*.
gi 225543461 1376 RARAKR 1381
Cdd:COG1729   107 RARLAR 112
PHA02946 PHA02946
ankyin-like protein; Provisional
 1096-1299 3.30e-06

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 51.59  E-value: 3.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1096 ELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL--MVAACEGHLSTVEFLLSKGAAL-S 1172
Cdd:PHA02946   56 EELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYGAKInN 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1173 SLDKEGLSALsWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPL--DLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDr 1250
Cdd:PHA02946  136 SVDEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIhrHLMSDNPKASTISWMMKLGISPSKPDHDGNTPLH- 213

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1251 aIGC----RNTSVVVALL-----RKGAKLGNAAWAM--ATSKPDILIillQKLMEEGNVM 1299
Cdd:PHA02946  214 -IVCsktvKNVDIINLLLpstdvNKQNKFGDSPLTLliKTLSPAHLI---NKLLSTSNVI 269
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1308-1406 4.16e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 49.91  E-value: 4.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1308 AAQRYQYALRKFPREGFGEDMRPFNELR----VSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNS 1383
Cdd:COG4785    41 LADLALALAAAALAAAALAAERIDRALAlpdlAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLL 120

                          90       100
                  ....*....|....*....|...
gi 225543461 1384 RQFVAALADLQEAVKLCPTNQEV 1406
Cdd:COG4785   121 GDYDAALEDFDRALELDPDYAYA 143
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1292-1418 5.35e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.11  E-value: 5.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1292 LMEEGNVMYKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYE 1371
Cdd:COG2956   147 YCELAELYLEQGDYDEAIEALEKALKLDPDC-------------ARALLLLAELYLEQGDYEEAIAALERALEQDPDYLP 213

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 225543461 1372 AFYARARAKRNSRQFVAALADLQEAVKLCPTNqEVKRLLARVEEECK 1418
Cdd:COG2956   214 ALPRLAELYEKLGDPEEALELLRKALELDPSD-DLLLALADLLERKE 259
PHA02798 PHA02798
ankyrin-like protein; Provisional
 1091-1243 5.92e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 50.99  E-value: 5.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1091 KLEVCELLLGHGAAVSRTNRRGVPPLfCA------ARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFL 1164
Cdd:PHA02798   50 STDIVKLFINLGANVNGLDNEYSTPL-CTilsnikDYKHMLDIVKILIENGADINKKNSDGETPLYCLLSNGYINNLEIL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1165 L---SKGAALSSLDKEGLSALSWACLKGHRA---VVQYLVEEGAAIDQ-TDKNGRTPLDLAAFYG----DAETVLYLVEK 1233
Cdd:PHA02798  129 LfmiENGADTTLLDKDGFTMLQVYLQSNHHIdieIIKLLLEKGVDINThNNKEKYDTLHCYFKYNidriDADILKLFVDN 208

                         170
                  ....*....|
gi 225543461 1234 GAVIEHVDHS 1243
Cdd:PHA02798  209 GFIINKENKS 218
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 1092-1220 6.12e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 49.05  E-value: 6.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1092 LEVCELLLGHGAAVS-RTNRRGVPPLfcaarqGHW---------QIVRLLLERGCDVNLSDKQGRTPLMV--AACEGHLS 1159
Cdd:PHA02859   66 VEILKFLIENGADVNfKTRDNNLSAL------HHYlsfnknvepEILKILIDSGSSITEEDEDGKNLLHMymCNFNVRIN 139

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225543461 1160 TVEFLLSKGAALSSLDKEGLSAL-SWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAF 1220
Cdd:PHA02859  140 VIKLLIDSGVSFLNKDFDNNNILySYILFHSDKKIFDFLTSLGIDINETNKSGYNCYDLIKF 201
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 1103-1233 3.45e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 48.99  E-value: 3.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1103 AAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQ--------------GRTPLMVAACEGHLSTVEFLLSKG 1168
Cdd:cd22194   132 AEYTEEAYEGQTALNIAIERRQGDIVKLLIAKGADVNAHAKGvffnpkykhegfyfGETPLALAACTNQPEIVQLLMEKE 211

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225543461 1169 AA-LSSLDKEG---LSALSWAC--LKGHRAVVQYLVE------EGAAIDQ-TDKNGRTPLDLAAFYGDAETVLYLVEK 1233
Cdd:cd22194   212 STdITSQDSRGntvLHALVTVAedSKTQNDFVKRMYDmillksENKNLETiRNNEGLTPLQLAAKMGKAEILKYILSR 289
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 905-1149 6.03e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.94  E-value: 6.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  905 LRNLYTPNVKVSRLLI--LGGANVNYRTEVLNNAPILCVQShLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMK 982
Cdd:PLN03192  494 LKNFLQHHKELHDLNVgdLLGDNGGEHDDPNMASNLLTVAS-TGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYED 572

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  983 LVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLrkshalqqaltaaasmghssvvqcllg 1062
Cdd:PLN03192  573 CVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISDPHAAGDL--------------------------- 625

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1063 mekehevevngtdtlwgetaLTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDV---N 1139
Cdd:PLN03192  626 --------------------LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVdkaN 685

                         250
                  ....*....|
gi 225543461 1140 LSDKQGRTPL 1149
Cdd:PLN03192  686 TDDDFSPTEL 695
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1079-1233 6.07e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.09  E-value: 6.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1079 GETALTAAAGRGKLEVCELLLghGAAVSRTNR-------RGVPPLFCAARQGHWQIVRLLLERGCDVN----------LS 1141
Cdd:cd22192    51 GETALHVAALYDNLEAAVVLM--EAAPELVNEpmtsdlyQGETALHIAVVNQNLNLVRELIARGADVVspratgtffrPG 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1142 DKQ----GRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID----------QT 1207
Cdd:cd22192   129 PKNliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYDLILSYDkeddlqpldlVP 208

                         170       180
                  ....*....|....*....|....*.
gi 225543461 1208 DKNGRTPLDLAAFYGDAETVLYLVEK 1233
Cdd:cd22192   209 NNQGLTPFKLAAKEGNIVMFQHLVQK 234
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 910-1139 1.02e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.97  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  910 TPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKL--VCLL 987
Cdd:PHA03100   83 TDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkiLKLL 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  988 TKKGVRVDHLDKkgqcalvhsalrghgdilqylltcewspgppqpgtlrkshalqqaltaaasmghssvVQCLLgmekEH 1067
Cdd:PHA03100  163 IDKGVDINAKNR---------------------------------------------------------VNYLL----SY 181

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225543461 1068 EVEVNGTDtLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1139
Cdd:PHA03100  182 GVPINIKD-VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1158-1291 1.07e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 46.49  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1158 LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVI 1237
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225543461 1238 EHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL------GNAA--WAMATSKPDILIILLQK 1291
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVnardkdGETPlhLAAYNGNLEIVKLLLEA 142
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1144-1176 2.21e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 2.21e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 225543461  1144 QGRTPLMVAACE-GHLSTVEFLLSKGAALSSLDK 1176
Cdd:pfam00023    1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1115-1143 2.57e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 2.57e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 225543461  1115 PLFCAA-RQGHWQIVRLLLERGCDVNLSDK 1143
Cdd:pfam00023    5 PLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 1079-1250 2.66e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 46.03  E-value: 2.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1079 GETALTAAA---GRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGH-----------WQIVRLLLERGCDVNLS--- 1141
Cdd:cd21882    26 GKTCLHKAAlnlNDGVNEAIMLLLEAAPDSGNPKELVNAPCTDEFYQGQtalhiaienrnLNLVRLLVENGADVSARatg 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1142 ---DKQGRT-------PLMVAACEGHLSTVEFLLSKG---AALSSLDKEGLSALSWACLKGHRAVVQY---------LVE 1199
Cdd:cd21882   106 rffRKSPGNlfyfgelPLSLAACTNQEEIVRLLLENGaqpAALEAQDSLGNTVLHALVLQADNTPENSafvcqmynlLLS 185

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 225543461 1200 EGAAIDQT-------DKNGRTPLDLAAFYGDAETVLYLVEKGAviehvdHSGMRPLDR 1250
Cdd:cd21882   186 YGAHLDPTqqleeipNHQGLTPLKLAAVEGKIVMFQHILQREF------SGPYQPLSR 237
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1144-1169 3.57e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 3.57e-04
                            10        20
                    ....*....|....*....|....*.
gi 225543461   1144 QGRTPLMVAACEGHLSTVEFLLSKGA 1169
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGA 26
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1302-1413 3.76e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.33  E-value: 3.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1302 KGKMKEAAQRYQYALRKFPRegfgedmrpfnelRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKR 1381
Cdd:COG2956    21 NGQPDKAIDLLEEALELDPE-------------TVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYL 87

                          90       100       110
                  ....*....|....*....|....*....|..
gi 225543461 1382 NSRQFVAALADLQEAVKLCPTNQEVKRLLARV 1413
Cdd:COG2956    88 KAGLLDRAEELLEKLLELDPDDAEALRLLAEI 119
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1079-1290 5.87e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 44.69  E-value: 5.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  1079 GETALTAAAgRGKLEVCELLLGHGAAVSR------------TNR--RGVPPLFCAARQGHWQIVRLLLERGCDVNL---- 1140
Cdd:TIGR00870   82 GDTLLHAIS-LEYVDAVEAILLHLLAAFRksgplelandqyTSEftPGITALHLAAHRQNYEIVKLLLERGASVPAracg 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  1141 -----SDKQ-----GRTPLMVAACEGHLSTVEFLLSKGAALSSLDKeglsaLSWACLkgHRAVVQ--------------- 1195
Cdd:TIGR00870  161 dffvkSQGVdsfyhGESPLNAAACLGSPSIVALLSEDPADILTADS-----LGNTLL--HLLVMEnefkaeyeelscqmy 233

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  1196 -YLVEEGAAIDQTDK-------NGRTPLDLAAFYGDAETVLYLVE-KGAVIEHVDH------SGMRPLDRAIGCRNTSVV 1260
Cdd:TIGR00870  234 nFALSLLDKLRDSKElevilnhQGLTPLKLAAKEGRIVLFRLKLAiKYKQKKFVAWpngqqlLSLYWLEELDGWRRKQSV 313

                          250       260       270
                   ....*....|....*....|....*....|
gi 225543461  1261 VALLrkgaklgnAAWAMATSKPDILIILLQ 1290
Cdd:TIGR00870  314 LELI--------VVFVIGLKFPELSDMYLI 335
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1111-1139 6.56e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.78  E-value: 6.56e-04
                           10        20
                   ....*....|....*....|....*....
gi 225543461  1111 RGVPPLFCAARQGHWQIVRLLLERGCDVN 1139
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1210-1238 1.15e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 1.15e-03
                            10        20
                    ....*....|....*....|....*....
gi 225543461   1210 NGRTPLDLAAFYGDAETVLYLVEKGAVIE 1238
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1300-1412 1.37e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.53  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461  1300 YKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARA 1379
Cdd:TIGR02917  510 IQEGNPDDAIQRFEKVLTIDPKN-------------LRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQY 576

                           90       100       110
                   ....*....|....*....|....*....|...
gi 225543461  1380 KRNSRQFVAALADLQEAVKLCPTNQEVKRLLAR 1412
Cdd:TIGR02917  577 YLGKGQLKKALAILNEAADAAPDSPEAWLMLGR 609
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1194-1283 1.77e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.35  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1194 VQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNA 1273
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177

                          90
                  ....*....|
gi 225543461 1274 AwamATSKPD 1283
Cdd:PTZ00322  178 G---ANAKPD 184
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1115-1248 2.40e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.69  E-value: 2.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543461 1115 PLFCAARQGHWQ-IVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAAL------SSLdKEGLSALSWACL 1187
Cdd:cd22192    20 PLLLAAKENDVQaIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELvnepmtSDL-YQGETALHIAVV 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 225543461 1188 KGHRAVVQYLVEEGAAIDQ----------TDKN----GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1248
Cdd:cd22192    99 NQNLNLVRELIARGADVVSpratgtffrpGPKNliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
TPR_14 pfam13428
Tetratricopeptide repeat;
1371-1413 2.65e-03

Tetratricopeptide repeat;


Pssm-ID: 463874 [Multi-domain]  Cd Length: 44  Bit Score: 37.40  E-value: 2.65e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 225543461  1371 EAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARV 1413
Cdd:pfam13428    2 EALLALARALLALGDPDEALALLERALALDPDDPEAWLALAQL 44
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1111-1140 3.04e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 3.04e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 225543461   1111 RGVPPLFCAARQGHWQIVRLLLERGCDVNL 1140
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TPR_12 pfam13424
Tetratricopeptide repeat;
1296-1368 5.21e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 37.37  E-value: 5.21e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 225543461  1296 GNVMYKKGKMKEAAQRYQYALRKFpREGFGEDmrpfNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPK 1368
Cdd:pfam13424   10 AAVLRRLGRYDEALELLEKALEIA-RRLLGPD----HPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1363-1413 6.44e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.38  E-value: 6.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 225543461 1363 LELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARV 1413
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLA 51
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1210-1242 9.96e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 9.96e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 225543461  1210 NGRTPLDLAA-FYGDAETVLYLVEKGAVIEHVDH 1242
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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