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Conserved domains on  [gi|63054858|ref|NP_291022|]
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RCC1 domain-containing protein 1 [Homo sapiens]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 160-368 9.77e-26

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 106.21  E-value: 9.77e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054858 160 ARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVmaEVAAGGWHSVCVSETGDIYIWGWNES 239
Cdd:COG5184 151 VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSGVV--AVAAGGDHSCALKSDGTVWCWGSNSS 228

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054858 240 GQLAlptrnlaeDGETVAREatelnedgsqvkrtggaedgAPAPfiavqpfpalldLPMGSDAVKASCGSRHTAVVTRTG 319
Cdd:COG5184 229 GQLG--------DGTTTDRA--------------------TPVQ------------VAGLTGVVAIAAGGSHTCALKSDG 268

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 63054858 320 ELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDkqlqVKAVTCGPWNTYV 368
Cdd:COG5184 269 TVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG----VVAVAAGSSHTCA 313
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 160-368 9.77e-26

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 106.21  E-value: 9.77e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054858 160 ARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVmaEVAAGGWHSVCVSETGDIYIWGWNES 239
Cdd:COG5184 151 VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSGVV--AVAAGGDHSCALKSDGTVWCWGSNSS 228

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054858 240 GQLAlptrnlaeDGETVAREatelnedgsqvkrtggaedgAPAPfiavqpfpalldLPMGSDAVKASCGSRHTAVVTRTG 319
Cdd:COG5184 229 GQLG--------DGTTTDRA--------------------TPVQ------------VAGLTGVVAIAAGGSHTCALKSDG 268

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 63054858 320 ELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDkqlqVKAVTCGPWNTYV 368
Cdd:COG5184 269 TVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG----VVAVAAGSSHTCA 313
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
177-225 1.68e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 64.46  E-value: 1.68e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 63054858   177 GQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCV 225
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 160-368 9.77e-26

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 106.21  E-value: 9.77e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054858 160 ARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVmaEVAAGGWHSVCVSETGDIYIWGWNES 239
Cdd:COG5184 151 VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSGVV--AVAAGGDHSCALKSDGTVWCWGSNSS 228

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054858 240 GQLAlptrnlaeDGETVAREatelnedgsqvkrtggaedgAPAPfiavqpfpalldLPMGSDAVKASCGSRHTAVVTRTG 319
Cdd:COG5184 229 GQLG--------DGTTTDRA--------------------TPVQ------------VAGLTGVVAIAAGGSHTCALKSDG 268

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 63054858 320 ELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDkqlqVKAVTCGPWNTYV 368
Cdd:COG5184 269 TVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG----VVAVAAGSSHTCA 313
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 159-368 3.21e-23

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 98.90  E-value: 3.21e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054858 159 RARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMaeVAAGGWHSVCVSETGDIYIWGWNE 238
Cdd:COG5184  49 NVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVPGLTGVVA--VAAGYYHSCALKSDGTVWCWGDNS 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054858 239 SGQLAlptrnlaeDGETVAREAtelnedgsqvkrtggaedgapapfiavqpfPALLDLPMgSDAVKASCGSRHTAVVTRT 318
Cdd:COG5184 127 SGQLG--------DGTTTNRLT------------------------------PVQVDAGL-SGVVAIAAGGYHTCALKSD 167

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 63054858 319 GELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDkqlqVKAVTCGPWNTYV 368
Cdd:COG5184 168 GTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSG----VVAVAAGGDHSCA 213
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 161-368 1.52e-22

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 96.97  E-value: 1.52e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054858 161 RQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVmaEVAAGGWHSVCVSETGDIYIWGWNESG 240
Cdd:COG5184   1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSNVV--AVAAGGDHTCALKADGTVWCWGNNSYG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054858 241 QLAlptrnlaeDGETVAREatelnedgsqvkrtggaedgAPAPfiavqpfpalldLPMGSDAVKASCGSRHTAVVTRTGE 320
Cdd:COG5184  79 QLG--------DGTTTDRT--------------------TPVK------------VPGLTGVVAVAAGYYHSCALKSDGT 118

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 63054858 321 LYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKqlqVKAVTCGPWNTYV 368
Cdd:COG5184 119 VWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG---VVAIAAGGYHTCA 163
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 160-343 1.95e-22

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 96.58  E-value: 1.95e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054858 160 ARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVmaEVAAGGWHSVCVSETGDIYIWGWNES 239
Cdd:COG5184 201 VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTGVV--AIAAGGSHTCALKSDGTVWCWGDNSY 278

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054858 240 GQLAlptrnlaedgetvareatelneDGSQVKRTggaedgAPAPfiavqpfpalldLPMGSDAVKASCGSRHTAVVTRTG 319
Cdd:COG5184 279 GQLG----------------------DGTTTDRS------TPVK------------VPGLSGVVAVAAGSSHTCALLTDG 318

                       170       180
                ....*....|....*....|....
gi 63054858 320 ELYTWGWGKYGQLGHEDTTSLDRP 343
Cdd:COG5184 319 TVWCWGDNAYGQLGDGTTTDRSTP 342
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 159-247 2.60e-14

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 73.09  E-value: 2.60e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054858 159 RARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVmaEVAAGGWHSVCVSETGDIYIWGWNE 238
Cdd:COG5184 250 GVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSGVV--AVAAGSSHTCALLTDGTVWCWGDNA 327


                ....*....
gi 63054858 239 SGQLALPTR 247
Cdd:COG5184 328 YGQLGDGTT 336
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
177-225 1.68e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 64.46  E-value: 1.68e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 63054858   177 GQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCV 225
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
319-366 1.60e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 50.21  E-value: 1.60e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 63054858   319 GELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKqlQVKAVTCGPWNT 366
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGN--KVVQVACGGDHT 47
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
303-331 1.73e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 46.65  E-value: 1.73e-07
                          10        20
                  ....*....|....*....|....*....
gi 63054858   303 VKASCGSRHTAVVTRTGELYTWGWGKYGQ 331
Cdd:pfam13540   2 VSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
215-241 1.58e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 43.95  E-value: 1.58e-06
                          10        20
                  ....*....|....*....|....*..
gi 63054858   215 VAAGGWHSVCVSETGDIYIWGWNESGQ 241
Cdd:pfam13540   4 VAAGDNHTLALTSDGRVYCWGDNSYGQ 30
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 159-201 4.36e-04

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 41.89  E-value: 4.36e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 63054858 159 RARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEP 201
Cdd:COG5184 300 GVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTP 342
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
161-189 3.95e-03

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 34.32  E-value: 3.95e-03
                          10        20
                  ....*....|....*....|....*....
gi 63054858   161 RQLELGAEHALLLDAAGQVFSWGGGRHGQ 189
Cdd:pfam13540   2 VSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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