NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|16077456|ref|NP_388270|]
View 

putative transcriptional regulator (ArsR family) [Bacillus subtilis subsp. subtilis str. 168]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-94 1.58e-22

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 83.40  E-value: 1.58e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077456   1 MNIPNHPEtetlQLTKVLHALSDPLRLELVKQLAEaKEKTCSTCAD-VQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYS 79
Cdd:COG0640   1 MSETKELE----ELAELFKALADPTRLRILRLLAE-GELCVGELAEaLGLSQSTVSHHLKVLREAGLVTSRREGRWVYYR 75

                        90
                ....*....|....*
gi 16077456  80 LRAEDLEKAFPGLLE 94
Cdd:COG0640  76 LADEALAELLEWLLE 90
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-94 1.58e-22

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 83.40  E-value: 1.58e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077456   1 MNIPNHPEtetlQLTKVLHALSDPLRLELVKQLAEaKEKTCSTCAD-VQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYS 79
Cdd:COG0640   1 MSETKELE----ELAELFKALADPTRLRILRLLAE-GELCVGELAEaLGLSQSTVSHHLKVLREAGLVTSRREGRWVYYR 75

                        90
                ....*....|....*
gi 16077456  80 LRAEDLEKAFPGLLE 94
Cdd:COG0640  76 LADEALAELLEWLLE 90
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 14-89 7.09e-16

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 65.94  E-value: 7.09e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16077456   14 LTKVLHALSDPLRLELVKQLAEAKEKTCSTCADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDLEKAF 89
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
28-93 1.03e-13

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 60.30  E-value: 1.03e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16077456     28 ELVKQLAEAKEKTCSTCADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDLEKAFPGLL 93
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-84 8.85e-13

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 58.46  E-value: 8.85e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16077456  18 LHALSDPLRLELVKQLAEAKEKTCSTCADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAED 84
Cdd:cd00090   1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAE 67
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 23-66 9.93e-12

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 54.76  E-value: 9.93e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 16077456    23 DPLRLELVKQLAEAKEKTCSTCADVQVAKSTLSHHFKVLRESGI 66
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGL 44
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 17-80 5.35e-08

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 45.87  E-value: 5.35e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16077456   17 VLHALSDPLR---LELVKQlaeaKEKTCSTCAD-VQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSL 80
Cdd:NF033789   1 TFKALSDPTRreiLELLKE----GDMTAGEIAEhFDMSKPSISHHLNILKQADLVTDERKGQFIYYSL 64
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 11-80 2.40e-05

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 40.18  E-value: 2.40e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16077456   11 TLQLTKVLhalSDPLRLELVKQLAEAKEK-TCSTCADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSL 80
Cdd:PRK10141   6 PLQLFKIL---SDETRLGIVLLLRESGELcVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-94 1.58e-22

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 83.40  E-value: 1.58e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077456   1 MNIPNHPEtetlQLTKVLHALSDPLRLELVKQLAEaKEKTCSTCAD-VQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYS 79
Cdd:COG0640   1 MSETKELE----ELAELFKALADPTRLRILRLLAE-GELCVGELAEaLGLSQSTVSHHLKVLREAGLVTSRREGRWVYYR 75

                        90
                ....*....|....*
gi 16077456  80 LRAEDLEKAFPGLLE 94
Cdd:COG0640  76 LADEALAELLEWLLE 90
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 14-89 7.09e-16

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 65.94  E-value: 7.09e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16077456   14 LTKVLHALSDPLRLELVKQLAEAKEKTCSTCADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDLEKAF 89
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
28-93 1.03e-13

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 60.30  E-value: 1.03e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16077456     28 ELVKQLAEAKEKTCSTCADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDLEKAFPGLL 93
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-84 8.85e-13

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 58.46  E-value: 8.85e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16077456  18 LHALSDPLRLELVKQLAEAKEKTCSTCADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAED 84
Cdd:cd00090   1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAE 67
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 23-66 9.93e-12

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 54.76  E-value: 9.93e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 16077456    23 DPLRLELVKQLAEAKEKTCSTCADVQVAKSTLSHHFKVLRESGI 66
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGL 44
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 16-74 1.54e-09

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 49.46  E-value: 1.54e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077456    16 KVLHALSDPLRLELVKQLAEAKEKTCSTCAD-VQVAKSTLSHHFKVLRESGIAQVRIEGK 74
Cdd:pfam12840   2 DVAEALADPTRLRILRALVGDEPLTASELARrLDISRNTLSYHLRKLEEAGLVEVVREGR 61
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 17-80 5.35e-08

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 45.87  E-value: 5.35e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16077456   17 VLHALSDPLR---LELVKQlaeaKEKTCSTCAD-VQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSL 80
Cdd:NF033789   1 TFKALSDPTRreiLELLKE----GDMTAGEIAEhFDMSKPSISHHLNILKQADLVTDERKGQFIYYSL 64
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 11-80 2.40e-05

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 40.18  E-value: 2.40e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16077456   11 TLQLTKVLhalSDPLRLELVKQLAEAKEK-TCSTCADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSL 80
Cdd:PRK10141   6 PLQLFKIL---SDETRLGIVLLLRESGELcVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
16-85 1.32e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 38.71  E-value: 1.32e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16077456  16 KVLHALSDPLRLELVKQLAEAKEKTCSTCAD-VQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDL 85
Cdd:COG3398  89 KILAYLRRETPRRILLYLLENPGATNKELAEeLGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPPER 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH