|
Name |
Accession |
Description |
Interval |
E-value |
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
140-606 |
0e+00 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 626.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 140 YITDDYERLVENLPSPL-CISVKGKIVYVNSAMLSMLGaKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ 218
Cdd:COG5805 31 EITEELETILENLPDAIiAVNREGKVIYINPAMEKLLG-YTSEEIIGKTIFDFLEKEYHYRVKTRIERLQKGYDVVMIEQ 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 219 TWKrLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNSIDTIAVIH-NGKWVFMNESGIS 297
Cdd:COG5805 110 IYC-KDGELIYVEVKLFPIYNQNGQAAILALRDITKKKKIEEILQEQEERLQTLIENSPDLICVIDtDGRILFINESIER 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 298 LFEAATYEdLIGKNIYDQLHPCDHEDVKERIQNIAEQKTESEIVKqSWFTFQNRVIYTEMVCIP--TTFFGEAAVQVILR 375
Cdd:COG5805 189 LFGAPREE-LIGKNLLELLHPCDKEEFKERIESITEVWQEFIIER-EIITKDGRIRYFEAVIVPliDTDGSVKGILVILR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 376 DISERKQTEELMLKSEKLSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELLMLAKP 455
Cdd:COG5805 267 DITEKKEAEELMARSEKLSIAGQLAAGIAHEIRNPLTSIKGFLQLLQPGIEDKEEYFDIMLSELDRIESIISEFLALAKP 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 456 QQNaVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDE 535
Cdd:COG5805 347 QAV-NKEKENINELIQDVVTLLETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEED 425
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16078463 536 HSVHVTVKDEGEGIPEKVLNRIGEPFLTTKEKGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK 606
Cdd:COG5805 426 NSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
143-606 |
8.35e-135 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 402.43 E-value: 8.35e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 143 DDYERLVENLPSPLCI-SVKGKIVYVNSAMLSMLGAkSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQTWK 221
Cdd:COG5809 15 QRFRSLFENAPDAILIlDLEGKILKVNPAAERIFGY-TEDELLGTNILDFLHPDDEKELREILKLLKEGESRDELEFELR 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 222 RLDGTPVHLEVKASPTVYKNQQAELLLLI--DISSRKKFQTILQKSRERYQLLIQNSIDTIAVI-HNGKWVFMNESGISL 298
Cdd:COG5809 94 HKNGKRLEFSSKLSPIFDQNGDIEGMLAIsrDITERKRMEEALRESEEKFRLIFNHSPDGIIVTdLDGRIIYANPAACKL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 299 FEAaTYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQKTESEIVKQSWfTFQNRVIYTEMVCIPTTFFGEAAVQV-ILRDI 377
Cdd:COG5809 174 LGI-SIEELIGKSILELIHSDDQENVAAFISQLLKDGGIAQGEVRFW-TKDGRWRLLEASGAPIKKNGEVDGIViIFRDI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 378 SERKQTEELMLKSEKLSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPT-MEGNEHYFDIVFSELSRIELILSELLMLAKPQ 456
Cdd:COG5809 252 TERKKLEELLRKSEKLSVVGELAAGIAHEIRNPLTSLKGFIQLLKDTiDEEQKTYLDIMLSELDRIESIISEFLVLAKPQ 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 457 qnAVK-EYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIIT-ED 534
Cdd:COG5809 332 --AIKyEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKaED 409
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16078463 535 EHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKEKGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK 606
Cdd:COG5809 410 DDKVVISVTDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIK 481
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
262-604 |
5.22e-94 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 292.91 E-value: 5.22e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 262 LQKSRERYQLLIQNSIDTIAVIH-NGKWVFMNESGISLFEAATyEDLIGKNIYDQLHpcDHEDVKERIQNIAEQKTESEI 340
Cdd:COG3852 2 LRESEELLRAILDSLPDAVIVLDaDGRITYVNPAAERLLGLSA-EELLGRPLAELFP--EDSPLRELLERALAEGQPVTE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 341 VKQSWFTFQNRVIYTEMVCIPTTFF-GEAAVQVILRDISERKQTEELMLKSEKLSIAGQLAAGIAHEIRNPLTAIKGFLQ 419
Cdd:COG3852 79 REVTLRRKDGEERPVDVSVSPLRDAeGEGGVLLVLRDITERKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 420 LMKPTMEGNE--HYFDIVFSELSRIELILSELLMLAKPQQnAVKEYLNLKKLIGEVSALLETQANlNGIFIRTSYEKDSI 497
Cdd:COG3852 159 LLERELPDDElrEYTQLIIEEADRLNNLVDRLLSFSRPRP-PEREPVNLHEVLERVLELLRAEAP-KNIRIVRDYDPSLP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 498 YINGDQNQLKQVFINLIKNAVESMPDGGTVdIIITEDEHS-----------VHVTVKDEGEGIPEKVLNRIGEPFLTTKE 566
Cdd:COG3852 237 EVLGDPDQLIQVLLNLVRNAAEAMPEGGTI-TIRTRVERQvtlgglrprlyVRIEVIDNGPGIPEEILDRIFEPFFTTKE 315
|
330 340 350
....*....|....*....|....*....|....*...
gi 16078463 567 KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:COG3852 316 KGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
253-604 |
9.52e-88 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 276.67 E-value: 9.52e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 253 SSRKKFQTILQKSRERYQLLIQNSIDTIAVIHNGKWVFMNESGISLFEAATyEDLIGKNIYDQLHPCDHEDVKERIqnIA 332
Cdd:COG5807 14 EKNQEFKLTEDSEFKFKQLFDSILEFVFFIDSKGEILECNDFAEDLYGLSQ-NEYIGKTFVEEKCILKDEQLYNKE--AF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 333 EQKTESEIVKQSWFtfqnRVIYTEMVCIPTTFFGeaaVQVILRDISERKQTEELMLKSEKLSIAGQLAAGIAHEIRNPLT 412
Cdd:COG5807 91 DRIEISYLTKNGEF----DEIIYPIYYKDGVILG---LITVYRDITKRKEAEDKLLRSEKLSVAGELAAGIAHEIRNPLT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 413 AIKGFLQLMKPTMEGN--EHYFDIVFSELSRIELILSELLMLAKPQQNAvKEYLNLKKLIGEVSALLETQANLNGIFIRT 490
Cdd:COG5807 164 SIKGFLQLLQESREDSerEEYFNIIISEIDRINTIITELLVLSKPKKFN-FKKLNLNDVLEDVIALLSTEAILKNISIKY 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 491 SYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKEKGTG 570
Cdd:COG5807 243 DLADDEPVINGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEGDFVVISVKDEGIGIPEEVLEKIGEPFFTTKEEGTG 322
|
330 340 350
....*....|....*....|....*....|....
gi 16078463 571 LGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:COG5807 323 LGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLP 356
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
387-606 |
2.59e-80 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 259.03 E-value: 2.59e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 387 MLKSEKLSIAGQLAAGIAHEIRNPLTAIKGFLQLMK---PTMEGNEHYFDIVFSELSRIELILSELLMLAKPQqNAVKEY 463
Cdd:COG5806 192 LQRAEKLEVVSELAASIAHEVRNPLTVVRGFIQLLQepeLSDEKRKQYIRIALEELDRAEAIITDYLTFAKPQ-PEKLEK 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 464 LNLKKLIGEVSALLETQANLNGIFIRTSYEkDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVK 543
Cdd:COG5806 271 IDVSEELEHVIDVLSPYANMNNVEIQTELE-PGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNKVIISIK 349
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16078463 544 DEGEGIPEKVLNRIGEPFLTTKEKGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK 606
Cdd:COG5806 350 DTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPLA 412
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
262-605 |
1.39e-79 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 257.58 E-value: 1.39e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 262 LQKSRERYQLLIQNSIDTIAVI-HNGKWVFMNESGISLFEAaTYEDLIGKNIYDQLHPCDHEDVkerIQNIAEQKTESEI 340
Cdd:COG5000 85 LEERRRYLETILENLPAGVIVLdADGRITLANPAAERLLGI-PLEELIGKPLEELLPELDLAEL---LREALERGWQEEI 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 341 VkqswFTFQNRVIYTemvCIPTTFFGEAAVqVILRDISErkqteelMLKSEKLSIAGQLAAGIAHEIRNPLTAIKGFLQL 420
Cdd:COG5000 161 E----LTRDGRRTLL---VRASPLRDDGYV-IVFDDITE-------LLRAERLAAWGELARRIAHEIKNPLTPIQLSAER 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 421 MK--------PTMEGNEHYFDIVFSELSRIELILSELLMLAKPQQnAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSY 492
Cdd:COG5000 226 LRrkladkleEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPE-PQLEPVDLNELLREVLALYEPALKEKDIRLELDL 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 493 EKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKEKGTGLG 572
Cdd:COG5000 305 DPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLG 384
|
330 340 350
....*....|....*....|....*....|...
gi 16078463 573 LMVTFNIIENHQGVIHVDSHPEKGTAFKISFPK 605
Cdd:COG5000 385 LAIVKKIVEEHGGTIELESRPGGGTTFTIRLPL 417
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
367-604 |
7.56e-71 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 232.77 E-value: 7.56e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 367 EAAVQVILRDISERKQTEELMLKSEKLSIAGQLAAGIAHEIRNPLTAIKGFLQLMK------PTMEGNEHYFDIVFSELS 440
Cdd:COG4191 113 ERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELLRrrledePDPEELREALERILEGAE 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 441 RIELILSELLMLAKPQQnAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKNAVES 520
Cdd:COG4191 193 RAAEIVRSLRAFSRRDE-EEREPVDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIDA 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 521 MPDG--GTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE--KGTGLGLMVTFNIIENHQGVIHVDSHPEKG 596
Cdd:COG4191 272 MEEGegGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPvgKGTGLGLSISYGIVEKHGGRIEVESEPGGG 351
|
....*...
gi 16078463 597 TAFKISFP 604
Cdd:COG4191 352 TTFTITLP 359
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
262-604 |
1.86e-61 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 214.45 E-value: 1.86e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 262 LQKSRERYQLLIQNSID-TIAVIHNGKWVFMNESGISLFEAATyEDLIGKNiYDQLHPCDhEDVKERIQNIAEQKTEseI 340
Cdd:PRK11360 257 LRETRSLNELILESIADgVIAIDRQGKITTMNPAAEVITGLQR-HELVGKP-YSELFPPN-TPFASPLLDTLEHGTE--H 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 341 VKQSWfTFQNR------VIYTEMVCIPTtffGEA--AVqVILRDISERKQTEELMLKSEKLSIAGQLAAGIAHEIRNPLT 412
Cdd:PRK11360 332 VDLEI-SFPGRdrtielSVSTSLLHNTH---GEMigAL-VIFSDLTERKRLQRRVARQERLAALGELVAGVAHEIRNPLT 406
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 413 AIKGFLQLM--KPTMEGNEHYFDIVFSELSRIELILSELLMLAKPQQnAVKEYLNLKKLIGEVSALLETQANLNGIFIRT 490
Cdd:PRK11360 407 AIRGYVQIWrqQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRE-SQWQPVSLNALVEEVLQLFQTAGVQARVDFET 485
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 491 SYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDI---IITEDEhsVHVTVKDEGEGIPEKVLNRIGEPFLTTKEK 567
Cdd:PRK11360 486 ELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIrtwQYSDGQ--VAVSIEDNGCGIDPELLKKIFDPFFTTKAK 563
|
330 340 350
....*....|....*....|....*....|....*..
gi 16078463 568 GTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:PRK11360 564 GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
397-605 |
2.72e-59 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 200.90 E-value: 2.72e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 397 GQLAAGIAHEIRNPLTAIKGFLQLMKPTM-EGNEHYFDIVFSELSRIELILSELLMLAKPQQNAV---KEYLNLKKLIGE 472
Cdd:COG0642 111 SRFLANVSHELRTPLTAIRGYLELLLEELdEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLelePEPVDLAELLEE 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 473 VSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEK 552
Cdd:COG0642 191 VVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPE 270
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 16078463 553 VLNRIGEPFLTTKE----KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPK 605
Cdd:COG0642 271 DLERIFEPFFRTDPsrrgGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPL 327
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
246-606 |
3.63e-58 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 200.16 E-value: 3.63e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 246 LLLLIDISSRKKFQTILQKSRERYQLLIQNSIDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVK 325
Cdd:COG5002 24 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 326 ERIQNIAEQKTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELmlKSEklsiagqLAAGIAH 405
Cdd:COG5002 104 LLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQM--RRE-------FVANVSH 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 406 EIRNPLTAIKGFLQLMK----PTMEGNEHYFDIVFSELSRIELILSELLMLAKPQQNAV---KEYLNLKKLIGEVSALLE 478
Cdd:COG5002 175 ELRTPLTSIRGYLELLLdgaaDDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELkleKEPVDLAELLEEVVEELR 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 479 TQANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIG 558
Cdd:COG5002 255 PLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIF 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 16078463 559 EPF------LTTKEKGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK 606
Cdd:COG5002 335 ERFyrvdksRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLA 388
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
379-606 |
8.64e-58 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 200.75 E-value: 8.64e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 379 ERKQTEElmlKSEKLSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEH--YFDIVFSELSRIELILSELLMLAKPQ 456
Cdd:COG5808 227 ERVIQEI---NTQKLELIGTFAASTAHEIRNPLTSIKGFIQLLQEKYPELEDqkYFDIIQEEIQRINQIVSEFLVLGKPT 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 457 QNAVKEYlNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEH 536
Cdd:COG5808 304 AKKLELD-DLNELIEEILSIIDSEANLKNIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKEGGKLTISIENDDE 382
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 537 SVHVTVKDEGEGIPEKVLNRIGEPFLTTKEKGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK 606
Cdd:COG5808 383 KAVIEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLPLK 452
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
380-605 |
1.37e-54 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 185.50 E-value: 1.37e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 380 RKQTEELMlKSEKLsiAGQLAAGIAHEIRNPLTAIKGFLQLMK----PTMEGNEHYFDIVFSELSRIELILSELLMLAKP 455
Cdd:COG2205 3 EEALEELE-ELERL--KSEFLANVSHELRTPLTSILGAAELLLdeedLSPEERRELLEIIRESAERLLRLIEDLLDLSRL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 456 QQNAV---KEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIIT 532
Cdd:COG2205 80 ESGKLsleLEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISAR 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16078463 533 EDEHSVHVTVKDEGEGIPEKVLNRIGEPF----LTTKEKGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPK 605
Cdd:COG2205 160 REGDGVRISVSDNGPGIPEEELERIFERFyrgdNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
380-606 |
2.87e-44 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 163.80 E-value: 2.87e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 380 RKQTEELMLKSEKLSIAGQLAAGIAHEIRNPLTAIKG----FLQLMKPTMEGNEhYFDIVFSELSRIELILSELLMLAKP 455
Cdd:PRK10364 221 RQLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGlakyFAERAPAGGEAHQ-LAQVMAKEADRLNRVVSELLELVKP 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 456 QQNAVKEyLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDE 535
Cdd:PRK10364 300 THLALQA-VDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESG 378
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16078463 536 HSVHVTVKDEGEGIPEKVLNRIGEPFLTTKEKGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK 606
Cdd:PRK10364 379 AGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVN 449
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
380-604 |
3.91e-34 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 138.66 E-value: 3.91e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 380 RKQTEELMLK-----SEKLSIAGQLAAGIAHEIRNPLTAIKGFLQL----MKPTMEGNEHYFDIVfSELSRIELILSELL 450
Cdd:PRK13837 429 RLETERDALErrlehARRLEAVGTLASGIAHNFNNILGAILGYAEMalnkLARHSRAARYIDEII-SAGARARLIIDQIL 507
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 451 MLAKPQQNAVKEYlNLKKLIGEVSALLeTQANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDII 530
Cdd:PRK13837 508 AFGRKGERNTKPF-DLSELVTEIAPLL-RVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDIS 585
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 531 I--------TEDEHS-------VHVTVKDEGEGIPEKVLNRIGEPFLTTKEKGTGLGLMVTFNIIENHQGVIHVDSHPEK 595
Cdd:PRK13837 586 LsraklrapKVLSHGvlppgryVLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGR 665
|
....*....
gi 16078463 596 GTAFKISFP 604
Cdd:PRK13837 666 GTRFDVYLP 674
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
501-606 |
2.01e-33 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 123.53 E-value: 2.01e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 501 GDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE-----KGTGLGLMV 575
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKrsrkiGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|.
gi 16078463 576 TFNIIENHQGVIHVDSHPEKGTAFKISFPKK 606
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
242-606 |
5.91e-31 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 126.82 E-value: 5.91e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 242 QQAELLLLIDISSRKKFQTILQKSRERYQLLIQNSIDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDH 321
Cdd:COG4251 123 LALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLL 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 322 EDVKERIQNIAEQKTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQ-TEELMLKSEKLSIA---- 396
Cdd:COG4251 203 LRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEElEEELEERTAELERSneel 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 397 GQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGN-----EHYFDIVFSELSRIELILSELLMLAK-PQQNAVKEYLNLKKLI 470
Cdd:COG4251 283 EQFAYVASHDLREPLRKISGFSQLLEEDYGDKldeegREYLERIRDAAERMQALIDDLLAYSRvGRQELEFEPVDLNELL 362
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 471 GEVSALLETQANLNGIFIRTSyekDSIYINGDQNQLKQVFINLIKNAVESMPDG--GTVDIIITEDEHSVHVTVKDEGEG 548
Cdd:COG4251 363 EEVLEDLEPRIEERGAEIEVG---PLPTVRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFSVRDNGIG 439
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16078463 549 IPEKVLNRIGEPF--LTTKEK--GTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK 606
Cdd:COG4251 440 IDPEYAEKIFEIFqrLHSRDEyeGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKA 501
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
506-603 |
7.06e-31 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 116.16 E-value: 7.06e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 506 LKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTK----EKGTGLGLMVTFNIIE 581
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDksreGGGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 16078463 582 NHQGVIHVDSHPEKGTAFKISF 603
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
145-385 |
6.14e-29 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 115.89 E-value: 6.14e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 145 YERLVENLPSPLCI-SVKGKIVYVNSAMLSMLGaKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQTWKRL 223
Cdd:COG2202 13 LRALVESSPDAIIItDLDGRILYVNPAFERLTG-YSAEELLGKTLRDLLPPEDDDEFLELLRAALAGGGVWRGELRNRRK 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 224 DGTPVHLEVKASPTVYKNQQAELLLLI--DISSRKKFQTILQKSRERYQLLIQNSIDTIAVI-HNGKWVFMNESGISLFE 300
Cdd:COG2202 92 DGSLFWVELSISPVRDEDGEITGFVGIarDITERKRAEEALRESEERLRLLVENAPDGIFVLdLDGRILYVNPAAEELLG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 301 aATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQKTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGE-AAVQVILRDISE 379
Cdd:COG2202 172 -YSPEELLGKSLLDLLHPEDRERLLELLRRLLEGGRESYELELRLKDGDGRWVWVEASAVPLRDGGEvIGVLGIVRDITE 250
|
....*.
gi 16078463 380 RKQTEE 385
Cdd:COG2202 251 RKRAEE 256
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
501-606 |
4.39e-28 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 108.22 E-value: 4.39e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 501 GDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHsVHVTVKDEGEGIPEKVLNRIGEPFLT---TKEKGTGLGLMVTF 577
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIVR 79
|
90 100
....*....|....*....|....*....
gi 16078463 578 NIIENHQGVIHVDSHPEKGTAFKISFPKK 606
Cdd:pfam02518 80 KLVELLGGTITVESEPGGGTTVTLTLPLA 108
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
505-604 |
7.47e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 107.51 E-value: 7.47e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 505 QLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE--KGTGLGLMVTFNIIEN 582
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvgEGTGLGLSLSYRIIQK 82
|
90 100
....*....|....*....|..
gi 16078463 583 HQGVIHVDSHPEKGTAFKISFP 604
Cdd:cd16943 83 HGGTIRVASVPGGGTRFTIILP 104
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
404-606 |
4.55e-27 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 114.56 E-value: 4.55e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 404 AHEIRNPLTAIKGFLQLMKPTMEGN--EHYFDIVFSELSRIELILSELLMLAK---PQQNAVKEYLNLKKLIGEVSALLE 478
Cdd:PRK11100 264 THELKSPLAAIRGAAELLQEDPPPEdrARFTGNILTQSARLQQLIDRLLELARleqRQELEVLEPVALAALLEELVEARE 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 479 TQANLNGIFIRtsYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIG 558
Cdd:PRK11100 344 AQAAAKGITLR--LRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIF 421
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 16078463 559 EPFLT-----TKEKGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK 606
Cdd:PRK11100 422 ERFYSlprpaNGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRH 474
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
364-604 |
4.12e-26 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 112.46 E-value: 4.12e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 364 FFGEaavQVilrDISERKQTEELMLKSEKLSIAGQLAAGIAHEIRNPLTAIKGFLQLM-----KPTMEGNEHYF--DIVF 436
Cdd:PRK13557 137 FFGS---QL---DVSRRRDAEDALRQAQKMEALGQLTGGIAHDFNNLLQVMSGYLDVIqaalsHPDADRGRMARsvENIR 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 437 SELSRIELILSELLMLAKpQQNAVKEYLNLKKLIGEVSALLEtQANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKN 516
Cdd:PRK13557 211 AAAERAATLTQQLLAFAR-KQRLEGRVLNLNGLVSGMGELAE-RTLGDAVTIETDLAPDLWNCRIDPTQAEVALLNVLIN 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 517 AVESMPDGGTVDI------IITEDEHS---------VHVTVKDEGEGIPEKVLNRIGEPFLTTKE--KGTGLGLMVTFNI 579
Cdd:PRK13557 289 ARDAMPEGGRVTIrtrnveIEDEDLAMyhglppgryVSIAVTDTGSGMPPEILARVMDPFFTTKEegKGTGLGLSMVYGF 368
|
250 260
....*....|....*....|....*
gi 16078463 580 IENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:PRK13557 369 AKQSGGAVRIYSEVGEGTTVRLYFP 393
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
506-604 |
1.01e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 99.01 E-value: 1.01e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 506 LKQVFINLIKNAVESMPDGGTVDIIITEDEHSV-----------HVTVKDEGEGIPEKVLNRIGEPFLTTKEKGTGLGLM 574
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGGEIILRTRTQRQVtlghprhrlalRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLA 80
|
90 100 110
....*....|....*....|....*....|
gi 16078463 575 VTFNIIENHQGVIHVDSHPEKgTAFKISFP 604
Cdd:cd16918 81 IAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
379-596 |
5.15e-24 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 106.69 E-value: 5.15e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 379 ERKQTEELMLKSEKLSIAGQLAAGIAHEIRNPLTAIKGFL-----QLMKPTMEGNEHYFDIVFSELSRIELILSELLMLA 453
Cdd:COG4192 416 NLRQTQDELIQAAKMAVVGQTMTSLAHELNQPLNAMSMYLfsakkALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFS 495
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 454 KPQQNAVKEyLNLKKLIGEVSALLETQANLNGIFIRTSyekDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITE 533
Cdd:COG4192 496 RKSDTPLQP-VDLRQVIEQAWELVESRAKPQQITLHIP---DDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLS 571
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16078463 534 DEHSVHVTVKDEGEGIPekVLNRIGEPFLTTKEKGTGLGLMVTFNIIENHQGVIHVDSHPEKG 596
Cdd:COG4192 572 NAENLRVAISDNGNGWP--LVDKLFTPFTTTKEVGLGLGLSICRSIMQQFGGDLYLASTLERG 632
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
380-604 |
5.68e-24 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 104.26 E-value: 5.68e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 380 RKQTEELmlkSEKLSIAGQLAAGIAHEIRNPLTAIKGFLQ---------LMKPTMEGNEHYFDIVFSELSRIELILSELL 450
Cdd:PRK09303 138 RQENETL---LEQLKFKDRVLAMLAHDLRTPLTAASLALEtlelgqideDTELKPALIEQLQDQARRQLEEIERLITDLL 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 451 -----MLAKPQQNAVKeyLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGG 525
Cdd:PRK09303 215 evgrtRWEALRFNPQK--LDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGG 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 526 TVDIIITedeHS----VHVTVKDEGEGIPEKVLNRIgepFLTT-------KEKGTGLGLMVTFNIIENHQGVIHVDSHPE 594
Cdd:PRK09303 293 TITLSML---HRttqkVQVSICDTGPGIPEEEQERI---FEDRvrlprdeGTEGYGIGLSVCRRIVRVHYGQIWVDSEPG 366
|
250
....*....|
gi 16078463 595 KGTAFKISFP 604
Cdd:PRK09303 367 QGSCFHFTLP 376
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
388-606 |
5.24e-23 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 100.54 E-value: 5.24e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 388 LKSEKLSIAGQLAA-----GIAHEIRNPLTAIKGFLQL---MKPTMEGNEhYFDIVFSELSRIELILSELLmlaKPQQNA 459
Cdd:PRK11073 117 LSQEQLQHAQQVAArdlvrGLAHEIKNPLGGLRGAAQLlskALPDPALTE-YTKVIIEQADRLRNLVDRLL---GPQRPG 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 460 VKEYLNLKKLIGEVSALLETQANLNGIFIRtSYEKDSIYINGDQNQLKQVFINLIKNAVESM-PDGGTVdIIITEDEHSV 538
Cdd:PRK11073 193 THVTESIHKVAERVVQLVSLELPDNVRLIR-DYDPSLPELAHDPDQIEQVLLNIVRNALQALgPEGGTI-TLRTRTAFQL 270
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16078463 539 -----------HVTVKDEGEGIPEKVLNRIGEPFLTTKEKGTGLGLMVTFNIIENHQGVIHVDSHPEKgTAFKISFPKK 606
Cdd:PRK11073 271 tlhgeryrlaaRIDIEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPIR 348
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
237-606 |
7.75e-23 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 101.08 E-value: 7.75e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 237 TVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNSIDTIAVIHNGKWVFMNESGISLFEAatyeDLIGKNIYDQL 316
Cdd:COG3290 55 ILLLILLLLLLLLLAALLLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGL----DAIGRPIDEVL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 317 HPCDHEDVKERIQNIAEQKTeseIVKQSWFTFQNRVIYTemvcipttffgeaavQVILRDISE-RKQTEELmlkSEKLSI 395
Cdd:COG3290 131 AEVLETGERDEEILLNGRVL---VVNRVPIRDDGRVVGA---------------VATFRDRTElERLEEEL---EGVKEL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 396 AGQLAAgIAHEIRNPLTAIKGFLQLmkptmegnEHYfdivfSELSR-IELILSELLMLAKPQQNAVKEYlnlkkligEVS 474
Cdd:COG3290 190 AEALRA-QRHDFRNHLHTISGLLQL--------GEY-----DEALEyIDEISEELQELIDSLLSRIGNP--------VLA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 475 ALLE---TQANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKNAVESM----PDGGTVDIIITEDEHSVHVTVKDEGE 547
Cdd:COG3290 248 ALLLgkaARARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAVeklpEEERRVELSIRDDGDELVIEVEDSGP 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 548 GIPEKVLNRIGEPFLTTK-EKGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK 606
Cdd:COG3290 328 GIPEELLEKIFERGFSTKlGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKE 387
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
154-604 |
2.82e-22 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 100.36 E-value: 2.82e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 154 SPLCISV---KGKIVYVNSAMLSMLGAkSKDAIIGK-----SSYEFIEEEYHDIVKnRIIRmqkgmevgmiEQTW----- 220
Cdd:TIGR02938 13 APLAISItdlKANILYANDAFTRITGY-TKEEIIGKnesvlSNHTTPPEVYQALWG-SLAE----------QKPWagkll 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 221 -KRLDGTPVHLEVKASPTVykNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNSIDTIAVihngKWVFMNESGISLF 299
Cdd:TIGR02938 81 nRRKDGELYLAELTVAPVL--NEAGETTHFLGMHRDITELHRLEQVVANQKLLIESVVDAAPV----AFVLLDPTGRVIL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 300 EAATYEDLI--------GKNIYDQLHPCDHEDVKERI-QNIAEQKTESEIVKQS-----WFTFQNRVIYTEMVCIPTTFF 365
Cdd:TIGR02938 155 DNQEYKKLAtdlrvkepAHTVLDLLREAWREALAENWpQQLAFSNREARFDRGGgrparWLSCTGSVIGMESDCADSFFC 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 366 G--EAAVQVILRDISERKQTEE---------LMLKSEKL-SIAGQLAAGIaHEIRNPLTAIKGFLQLM--KPTMEGNEHY 431
Cdd:TIGR02938 235 AaeQPYLLLTIADISNLREEQErarlsalqaLMAEEERLeAIRETLSAAI-HRLQGPMNLISAAISVLqrRGDDAGNPAS 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 432 FDIVFSELSRIELILSELLMLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQVFI 511
Cdd:TIGR02938 314 AAMLQQALSAGREHMEALRQVIPQSPQEIVVPVNLNQILRDVITLSTPRLLAAGIVVDWQPAATLPAILGRELQLRSLFK 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 512 NLIKNAVESMPDGGT----VDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTK---EKGTGLGLMVTFNIIENHQ 584
Cdd:TIGR02938 394 ALVDNAIEAMNIKGWkrreLSITTALNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKggsRKHIGMGLSVAQEIVADHG 473
|
490 500
....*....|....*....|
gi 16078463 585 GVIHVDSHPEKGTAFKISFP 604
Cdd:TIGR02938 474 GIIDLDDDYSEGCRIIVEFR 493
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
506-604 |
3.51e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 88.61 E-value: 3.51e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 506 LKQVFINLIKNAVESMPDGG--TVDIIIT---EDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKEKGTGLGLMVTFNII 580
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGceRRELTIRtspADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSII 80
|
90 100
....*....|....*....|....
gi 16078463 581 ENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:cd16920 81 EAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
381-604 |
2.65e-20 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 95.49 E-value: 2.65e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 381 KQTEELMLKSEKLSIAGQLAAGIAHEIRNPLTAIKG-----FLQLmkpTMEGNEH---YFDIVFSELSRIELIlSELLML 452
Cdd:PRK10490 649 ASEEQARLASEREQLRNALLAALSHDLRTPLTVLFGqaeilTLDL---ASEGSPHarqASEIRQQVLNTTRLV-NNLLDM 724
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 453 AKPQQ---NAVKEYLNLKKLIGevSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDI 529
Cdd:PRK10490 725 ARIQSggfNLRKEWLTLEEVVG--SALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGI 802
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16078463 530 IITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFL-TTKEK---GTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:PRK10490 803 DAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFArGNKESaipGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLP 881
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-604 |
3.18e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 86.05 E-value: 3.18e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 502 DQNQLKQVFINLIKNAVESM---PDG-GTVDIIITED-EHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKEKGTGLGLMVT 576
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIegrPSDvGEVRIRVEADqDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIV 80
|
90 100
....*....|....*....|....*...
gi 16078463 577 FNIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:cd16944 81 KKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
506-604 |
4.93e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 85.89 E-value: 4.93e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 506 LKQVFINLIKNAVESMPDGG-----TVDIIITEDEHSVH----------VTVKDEGEGIPEKVLNRIGEPFLTTKE--KG 568
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGrltieTSNQRVDADYALNYrdlipgnyvcLEVSDTGSGMPAEVLRRAFEPFFTTKEvgKG 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 16078463 569 TGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:cd16919 81 TGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
506-604 |
7.80e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 84.85 E-value: 7.80e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 506 LKQVFINLIKNAVESMPDGgTVDIII-----TEDEHSVHVTVKDEGEGIPEKVLNRIGEPF------LTTKEKGTGLGLM 574
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEG-EVTLRVsleeeEEDGVQLRFSVEDTGIGIPEEQQARLFEPFsqadssTTRKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|
gi 16078463 575 VTFNIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:cd16922 80 ISKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
506-599 |
1.93e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 83.66 E-value: 1.93e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 506 LKQVFINLIKNAVESMPD--GGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE--KGTGLGLMVTFNIIE 581
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKveNPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPvgKGTGLGLSISYGIVE 80
|
90
....*....|....*...
gi 16078463 582 NHQGVIHVDSHPEKGTAF 599
Cdd:cd16976 81 EHGGRLSVANEEGAGARF 98
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
403-604 |
2.07e-18 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 88.07 E-value: 2.07e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 403 IAHEIRNPLTAikgfLQLMKPTM-----EGNEhyfdivfseLSRIEL-------ILSELLMLAKPQQNA--VKEYLNLKK 468
Cdd:PRK09470 250 ISHELRTPLTR----LQLATALLrrrqgESKE---------LERIETeaqrldsMINDLLVLSRNQQKNhlERETFKANS 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 469 LIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKNAVESMPDggTVDIIITEDEHSVHVTVKDEGEG 548
Cdd:PRK09470 317 LWSEVLEDAKFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHT--KIEVAFSVDKDGLTITVDDDGPG 394
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16078463 549 IPEKVLNRIGEPFLTTKEK------GTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:PRK09470 395 VPEEEREQIFRPFYRVDEArdresgGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLP 456
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
267-377 |
3.98e-18 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 80.15 E-value: 3.98e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 267 ERYQLLIQNSIDTIAVI-HNGKWVFMNESGISLFEAATyEDLIGKNIYDQLHPCDHEDVKERIQNIAEQKTESEIVKQSW 345
Cdd:pfam00989 1 EDLRAILESLPDGIFVVdEDGRILYVNAAAEELLGLSR-EEVIGKSLLDLIPEEDDAEVAELLRQALLQGEESRGFEVSF 79
|
90 100 110
....*....|....*....|....*....|....
gi 16078463 346 FTFQNRVIYTEMVCIPTTFFGEAAVQVI--LRDI 377
Cdd:pfam00989 80 RVPDGRPRHVEVRASPVRDAGGEILGFLgvLRDI 113
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
400-605 |
5.08e-18 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 87.13 E-value: 5.08e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 400 AAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFS---ELSRIELILSELLMLAKPQQNAV---KEYLNLKKLIGEV 473
Cdd:PRK09835 266 SADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSnleELTRMAKMVSDMLFLAQADNNQLipeKKMLDLADEVGKV 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 474 SALLETQANLNGIFIRtsYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKV 553
Cdd:PRK09835 346 FDFFEAWAEERGVELR--FVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEH 423
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 16078463 554 LNRIGEPFLTT------KEKGTGLGLMVTFNIIENHQGVIHVDSHPeKGTAFKISFPK 605
Cdd:PRK09835 424 LPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLPR 480
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
373-606 |
2.82e-17 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 84.29 E-value: 2.82e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 373 ILRDISERKQTEelmlkseklSIAGQLAAGIAHEIRNPLTAIKGFLQLMK-PTMEG--NEHYFDIVFSELSRIELILSEL 449
Cdd:PRK11006 190 VARDVTQMHQLE---------GARRNFFANVSHELRTPLTVLQGYLEMMQdQPLEGalREKALHTMREQTQRMEGLVKQL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 450 LMLAK----PQ---QNAVKEYLNLKKLIGEVSALLETQANLngifirtSYEKD-SIYINGDQNQLKQVFINLIKNAVESM 521
Cdd:PRK11006 261 LTLSKieaaPTidlNEKVDVPMMLRVLEREAQTLSQGKHTI-------TFEVDnSLKVFGNEDQLRSAISNLVYNAVNHT 333
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 522 PDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFL------TTKEKGTGLGLMVTFNIIENHQGVIHVDSHPEK 595
Cdd:PRK11006 334 PEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYrvdkarSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGK 413
|
250
....*....|.
gi 16078463 596 GTAFKISFPKK 606
Cdd:PRK11006 414 GTRFSFVLPER 424
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
144-252 |
5.48e-17 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 77.07 E-value: 5.48e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 144 DYERLVENLPSPLC-ISVKGKIVYVNSAMLSMLGAKSKDaIIGKSSYEFIEEEYHDIVKNRIIRMQKGME-VGMIEQTWK 221
Cdd:pfam00989 2 DLRAILESLPDGIFvVDEDGRILYVNAAAEELLGLSREE-VIGKSLLDLIPEEDDAEVAELLRQALLQGEeSRGFEVSFR 80
|
90 100 110
....*....|....*....|....*....|...
gi 16078463 222 RLDGTPVHLEVKASPTVYKNQQAE--LLLLIDI 252
Cdd:pfam00989 81 VPDGRPRHVEVRASPVRDAGGEILgfLGVLRDI 113
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-603 |
2.69e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 75.13 E-value: 2.69e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 496 SIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVhVTVKDEGEGIPEKVLNRIGEPFL---TTKEKGTGLG 572
Cdd:cd16940 4 DIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYrsdGQNYGGSGLG 82
|
90 100 110
....*....|....*....|....*....|.
gi 16078463 573 LMVTFNIIENHQGVIHVDSHPEKGTAFKISF 603
Cdd:cd16940 83 LSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-599 |
3.25e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 74.42 E-value: 3.25e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 502 DQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLT-----TKEKGTGLGLMVT 576
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAFV 80
|
90 100
....*....|....*....|...
gi 16078463 577 FNIIENHQGVIHVDSHPEKGTAF 599
Cdd:cd16945 81 QEVAQLHGGRITLRNRPDGVLAF 103
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
398-605 |
4.57e-16 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 80.01 E-value: 4.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 398 QLAAGIAHEIRNPLTAIKGFLQLMKPTmegneHYFDIVfSELSRIELI---LSELLMLAKPQQN-AVKEYLNLKkLIGEV 473
Cdd:PRK10755 139 LFTADVAHELRTPLAGIRLHLELLEKQ-----HHIDVA-PLIARLDQMmhtVEQLLQLARAGQSfSSGHYQTVK-LLEDV 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 474 ----SALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGI 549
Cdd:PRK10755 212 ilpsQDELSEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGI 291
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 16078463 550 PEKVLNRIGEPF--LTTKEKGTGLGLMVTFNIIENHQGVIHVDSHPEK-GTAFKISFPK 605
Cdd:PRK10755 292 DESKCGELSKAFvrMDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQERsGTRAWVWLPK 350
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
497-602 |
1.23e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 73.70 E-value: 1.23e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 497 IYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE------KGTG 570
Cdd:cd16947 12 IYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDsrnsakQGNG 91
|
90 100 110
....*....|....*....|....*....|..
gi 16078463 571 LGLMVTFNIIENHQGVIHVDSHPEKGTAFKIS 602
Cdd:cd16947 92 LGLTITKRLAESMGGSIYVNSKPYEKTVFTVT 123
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
506-604 |
1.85e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 72.62 E-value: 1.85e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 506 LKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFL------TTKEKGTGLGLMVTFNI 579
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYrvdierCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 16078463 580 IENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFP 105
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
375-604 |
1.89e-15 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 79.98 E-value: 1.89e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 375 RDISERKQTEELMLKS--EKlsiaGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEH--YFDIVFseLSRIEL--ILSE 448
Cdd:PRK11091 264 RDITERKRYQDALEKAsrDK----TTFISTISHELRTPLNGIVGLSRILLDTELTAEQrkYLKTIH--VSAITLgnIFND 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 449 LLMLAKPQQNAVK---EYLNLKKLIGEVSALLETQANLNGIfiRTSYEKDS---IYINGDQNQLKQVFINLIKNAVESMP 522
Cdd:PRK11091 338 IIDMDKMERRKLQldnQPIDFTDFLADLENLSGLQAEQKGL--RFDLEPLLplpHKVITDGTRLRQILWNLISNAVKFTQ 415
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 523 DGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKEK-------GTGLGLMVTFNIIENHQGVIHVDSHPEK 595
Cdd:PRK11091 416 QGGVTVRVRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDShggkpatGTGIGLAVSKRLAQAMGGDITVTSEEGK 495
|
....*....
gi 16078463 596 GTAFKISFP 604
Cdd:PRK11091 496 GSCFTLTIH 504
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
398-604 |
3.31e-15 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 79.39 E-value: 3.31e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 398 QLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFD---IVFSELSRIELILSELLMLAKPQQNAVK---EYLNLKKLIG 471
Cdd:PRK09959 714 QFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEaisLAYATGQSLLGLIGEILDVDKIESGNYQlqpQWVDIPTLVQ 793
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 472 EVSALLETQANLNGIFIRTSYE-KDSIYINGDQNQLKQVFINLIKNAVESMPDGG---TVDIIITEDEHSV-HVTVKDEG 546
Cdd:PRK09959 794 NTCHSFGAIAASKSIALSCSSTfPDHYLVKIDPQAFKQVLSNLLSNALKFTTEGAvkiTTSLGHIDDNHAViKMTIMDSG 873
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16078463 547 EGIPE----KVLNRIGEPFLTTKEKGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:PRK09959 874 SGLSQeeqqQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-604 |
4.50e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 71.34 E-value: 4.50e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 502 DQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKEK------GTGLGLMV 575
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrnrasgGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 16078463 576 TFNIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
506-605 |
1.16e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 70.05 E-value: 1.16e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 506 LKQVFINLIKNAVESMPdgGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPF------LTTKEKGTGLGLMVTFNI 579
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFyrvdsaRDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 16078463 580 IENHQGVIHVDSHPEKGTAFKISFPK 605
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
401-604 |
2.29e-14 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 76.48 E-value: 2.29e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 401 AGIAHEIRNPLTAIKGFLQLM--KPTMEGNEHYFDIVFSELSRIELILSELLMLAKPQQNAVKEYLN-----LKKLIGEV 473
Cdd:PRK11466 449 AAMSHEIRTPLYGILGTAQLLadNPALNAQRDDLRAITDSGESLLTILNDILDYSAIEAGGKNVSVSdepfePRPLLEST 528
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 474 SALLETQANLNGIFIRTSYEKD-SIYINGDQNQLKQVFINLIKNAVEsMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEK 552
Cdd:PRK11466 529 LQLMSGRVKGRPIRLATDIADDlPTALMGDPRRIRQVITNLLSNALR-FTDEGSIVLRSRTDGEQWLVEVEDSGCGIDPA 607
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 16078463 553 VLNRIGEPF--LTTKEKGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:PRK11466 608 KLAEIFQPFvqVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
367-604 |
6.78e-14 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 75.06 E-value: 6.78e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 367 EAAVQVILRDISERKQTEELM--LKSEKLsiagqlaAGIAHEIRNPLTAIKGFLQLMKPT------MEGNEHYFDIVFSE 438
Cdd:PRK15347 374 ENKVAERTQALAEAKQRAEQAnkRKSEHL-------TTISHEIRTPLNGVLGALELLQNTpltaeqMDLADTARQCTLSL 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 439 L---------SRIELILSELLMlakpqqnavkEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKD-SIYINGDQNQLKQ 508
Cdd:PRK15347 447 LaiinnlldfSRIESGQMTLSL----------EETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHvPLYLHLDSLRLRQ 516
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 509 VFINLIKNAVESMPDGGTVDIIITEDEHsVHVTVKDEGEGIPEKVLNRIGEPFLTT--KEKGTGLGLMVTFNIIENHQGV 586
Cdd:PRK15347 517 ILVNLLGNAVKFTETGGIRLRVKRHEQQ-LCFTVEDTGCGIDIQQQQQIFTPFYQAdtHSQGTGLGLTIASSLAKMMGGE 595
|
250
....*....|....*...
gi 16078463 587 IHVDSHPEKGTAFKISFP 604
Cdd:PRK15347 596 LTLFSTPGVGSCFSLVLP 613
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
397-458 |
2.23e-13 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 65.31 E-value: 2.23e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16078463 397 GQLAAGIAHEIRNPLTAIKGFLQLMK--PTMEGNEHYFDIVFSELSRIELILSELLMLAKPQQN 458
Cdd:pfam00512 3 SEFLANLSHELRTPLTAIRGYLELLRdeKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
399-606 |
2.55e-13 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 72.25 E-value: 2.55e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 399 LAAGIAHEIRNPLTAIKGFLQLMKPtmeGNEHYFDIVFSELSRIELILSELLMLAKPQQNAVKEYLNLKKLIGEVSAlle 478
Cdd:PRK09467 232 LMAGVSHDLRTPLTRIRLATEMMSE---EDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNALLGEVIA--- 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 479 TQANLNGIfIRTSYEKDSIYINGDQNQLKQVFINLIKNAVESmpdgGTVDIIITE--DEHSVHVTVKDEGEGIPEKVLNR 556
Cdd:PRK09467 306 AESGYERE-IETALQPGPIEVPMNPIAIKRALANLVVNAARY----GNGWIKVSSgtEGKRAWFQVEDDGPGIPPEQLKH 380
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 16078463 557 IGEPFlTTKEK-----GTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK 606
Cdd:PRK09467 381 LFQPF-TRGDSargssGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLT 434
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
506-604 |
3.82e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 66.06 E-value: 3.82e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 506 LKQVFINLIKNAVE-SMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKEKG------TGLGLMVTFN 578
Cdd:cd16953 1 LGQVLRNLIGNAISfSPPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANeafgqhSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 16078463 579 IIENHQGVIHVDSHPE----KGTAFKISFP 604
Cdd:cd16953 81 IIEAHGGISVAENHNQpgqvIGARFTVQLP 110
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
404-602 |
1.16e-12 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 70.06 E-value: 1.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 404 AHEIRNPLTAIK---GFLQLMKPTMEGNEHYFDIVFSELSRIELILSELLMLAK----PQQNAVKEyLNLKKLIGevSAL 476
Cdd:PRK10337 245 AHELRSPLAALKvqtEVAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRldslDNLQDVAE-IPLEDLLQ--SAV 321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 477 LET--QANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDehsvHVTVKDEGEGIPEKVL 554
Cdd:PRK10337 322 MDIyhTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR----NFTVRDNGPGVTPEAL 397
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 16078463 555 NRIGEPFLTT--KEK-GTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKIS 602
Cdd:PRK10337 398 ARIGERFYRPpgQEAtGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVS 448
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
502-604 |
1.21e-12 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 64.44 E-value: 1.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 502 DQNQLKQVFINLIKNAVESMPDGGTVDIIITE-DEHSVHVTVKDEGEGIPEKVLNRIGEPFL------TTKEKGTGLGLM 574
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKfRLNRFLLTVSDSGPGIPPNLREEIFERFRqgdgssTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 16078463 575 VTFNIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
512-604 |
1.24e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 64.23 E-value: 1.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 512 NLIKNAVE---SMPDG-GTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE-KGTGLGLMVTFNIIENHQGV 586
Cdd:cd16915 7 NLIDNALDalaATGAPnKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGqGERGIGLALVRQSVERLGGS 86
|
90
....*....|....*...
gi 16078463 587 IHVDSHPEKGTAFKISFP 604
Cdd:cd16915 87 ITVESEPGGGTTFSIRIP 104
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
11-262 |
1.43e-12 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 68.13 E-value: 1.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 11 LQTKTDIHAVLASNGRIIYISANSKLHLGYLQGEMIGSFLKTFLHEEDQFLVESYFY---NEHHLMPCTFRFIKKDHTIV 87
Cdd:COG2202 17 VESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRaalAGGGVWRGELRNRRKDGSLF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 88 WVEAAVEIVTTRAER-----------TEReiilkmKVLEEETgHQSlncEKHeiepaspesttyitddYERLVENLPSPL 156
Cdd:COG2202 97 WVELSISPVRDEDGEitgfvgiardiTER------KRAEEAL-RES---EER----------------LRLLVENAPDGI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 157 CI-SVKGKIVYVNSAMLSMLGaKSKDAIIGKSSYEFIEEEYHDIVKNRIIR-MQKGMEVGMIEQTWKRLDGTPVHLEVKA 234
Cdd:COG2202 151 FVlDLDGRILYVNPAAEELLG-YSPEELLGKSLLDLLHPEDRERLLELLRRlLEGGRESYELELRLKDGDGRWVWVEASA 229
|
250 260
....*....|....*....|....*....
gi 16078463 235 SPTVYKNQQAELLLLI-DISSRKKFQTIL 262
Cdd:COG2202 230 VPLRDGGEVIGVLGIVrDITERKRAEEAL 258
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
401-604 |
1.53e-12 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 70.05 E-value: 1.53e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 401 AGIAHEIRNPLTAIKGFLQLM-----KPTMEGnehyFDIVFSELSRIELILSELLMLAKPQQNAV---KEYLNLKKLIgE 472
Cdd:PRK10549 245 ADISHELRTPLAVLRGELEAIqdgvrKFTPES----VASLQAEVGTLTKLVDDLHQLSLSDEGALayrKTPVDLVPLL-E 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 473 VSAlletqANLNGIF------IRTSYEkDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEG 546
Cdd:PRK10549 320 VAG-----GAFRERFasrgltLQLSLP-DSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSA 393
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16078463 547 EGIPEKVLNRIGEPFLTTKEK------GTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:PRK10549 394 PGVSDEQLQKLFERFYRTEGSrnrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELP 457
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
265-385 |
1.55e-12 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 64.62 E-value: 1.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 265 SRERYQLLIQNSIDTIAVI-HNGKWVFMNESGISLFeAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQktESEIVkQ 343
Cdd:TIGR00229 1 SEERYRAIFESSPDAIIVIdLEGNILYVNPAFEEIF-GYSAEELIGRNVLELIPEEDREEVRERIERRLEG--EPEPV-S 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 16078463 344 SWFTFQNR---VIYTEMVCIPTTFFGEA-AVQVILRDISERKQTEE 385
Cdd:TIGR00229 77 EERRVRRKdgsEIWVEVSVSPIRTNGGElGVVGIVRDITERKEAEE 122
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
397-454 |
1.84e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 62.62 E-value: 1.84e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16078463 397 GQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNE---HYFDIVFSELSRIELILSELLMLAK 454
Cdd:cd00082 5 GEFLANVSHELRTPLTAIRGALELLEEELLDDEeqrEYLERIREEAERLLRLINDLLDLSR 65
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
397-458 |
2.57e-12 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 62.20 E-value: 2.57e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16078463 397 GQLAAGIAHEIRNPLTAIKGFLQLMKPTM--EGNEHYFDIVFSELSRIELILSELLMLAKPQQN 458
Cdd:smart00388 3 REFLANLSHELRTPLTAIRGYLELLLDTElsEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-604 |
3.27e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 63.07 E-value: 3.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 502 DQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTK-----EKGTGLGLMVT 576
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGEngrnfQESTGMGLYLV 81
|
90 100
....*....|....*....|....*...
gi 16078463 577 FNIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:cd16948 82 KKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
387-604 |
1.39e-11 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 66.94 E-value: 1.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 387 MLKSEKlsiagQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDivfSELSRIELILSELLMLA---KPQQNAVKEY 463
Cdd:PRK10604 208 LIASKK-----QLIDGIAHELRTPLVRLRYRLEMSDNLSAAESQALN---RDIGQLEALIEELLTYArldRPQNELHLSE 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 464 LNLKKLIGEVsalLETQANLNG---IFIRTSYEKDsiYINGDQNQLKQVFINLIKNAVESMpdGGTVDIIITEDEHSVHV 540
Cdd:PRK10604 280 PDLPAWLSTH---LADIQAVTPektVRLDTPHQGD--YGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACL 352
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 541 TVKDEGEGIPEKVLNRIGEPFL------TTKEKGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:PRK10604 353 IVEDDGPGIPPEERERVFEPFVrldpsrDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
506-604 |
2.27e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 60.80 E-value: 2.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 506 LKQVFINLIKNAVESMPDGGTVDI----IITEDEHSVHVtvKDEGEGIPEKVLNRIGEPF--LTTKEK--GTGLGLMVTF 577
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIevgaEDVGEEWTFYV--RDNGIGIDPEYAEKVFGIFqrLHSREEyeGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 16078463 578 NIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-598 |
3.76e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 60.17 E-value: 3.76e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 502 DQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKEKGT-----GLGLMVT 576
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRsgghyGMGLYIA 80
|
90 100
....*....|....*....|..
gi 16078463 577 FNIIENHQGVIHVdSHPEKGTA 598
Cdd:cd16975 81 KNLVEKHGGSLII-ENSQKGGA 101
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
244-604 |
9.70e-11 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 64.54 E-value: 9.70e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 244 AELLLLIDISSRKKFQTILQKSRERYQLLIQNSIDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHED 323
Cdd:COG3920 145 ALAELAVALAELAAALLLLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLL 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 324 VKERIQNIAEQKTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEKLSIAgqLAAGI 403
Cdd:COG3920 225 VLLAALLRLRAAVLEELERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKEL--LLREL 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 404 AHEIRNPLTAIKGFLQLMKPTMEGNEHyfDIVFSEL-SRIELI--LSELLMlakpqQNAVKEYLNLKKLIGEVSALLETQ 480
Cdd:COG3920 303 HHRVKNNLQVVSSLLRLQARRADDPEA--REALEESqNRIQALalVHELLY-----QSEDWEGVDLRDYLRELLEPLRDS 375
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 481 ANLNGIfiRTSYEKDSIYINGDQ--------NQLkqvFINLIKNAVESMPDGgTVDIIITEDEHSVHVTVKDEGEGIPEK 552
Cdd:COG3920 376 YGGRGI--RIELDGPDVELPADAavplglilNEL---VTNALKHAFLSGEGG-RIRVSWRREDGRLRLTVSDNGVGLPED 449
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 16078463 553 VlnrigepfltTKEKGTGLGLMVTFNIIENHQGVIHVDShpEKGTAFKISFP 604
Cdd:COG3920 450 V----------DPPARKGLGLRLIRALVRQLGGTLELDR--PEGTRVRITFP 489
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
508-604 |
4.49e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 57.05 E-value: 4.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 508 QVFI-NLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTkEKGTGLGLmvtFNIIE----- 581
Cdd:cd16957 7 QVLVeNAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTS-EKGTGTAL---ENLNRrligl 82
|
90 100
....*....|....*....|....
gi 16078463 582 -NHQGVIHVDSHPEKGTAFKISFP 604
Cdd:cd16957 83 fGSEACLHIESEVHGGTEVWFVIP 106
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
512-606 |
8.82e-10 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 61.19 E-value: 8.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 512 NLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPfLTTKEKGTGLGLMVTFNIIENHQG---VIH 588
Cdd:COG2972 347 NAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEE-LSSKGEGRGIGLRNVRERLKLYYGeeyGLE 425
|
90
....*....|....*...
gi 16078463 589 VDSHPEKGTAFKISFPKK 606
Cdd:COG2972 426 IESEPGEGTTVTIRIPLE 443
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
498-604 |
9.48e-10 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 61.91 E-value: 9.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 498 YINGDQNQLKQVFINLIKNAVEsMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFL---TTKEK---GTGL 571
Cdd:PRK10841 555 ALNGDPMRLQQVISNLLSNAIK-FTDTGCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFqvgTGVQRnfqGTGL 633
|
90 100 110
....*....|....*....|....*....|...
gi 16078463 572 GLMVTFNIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:PRK10841 634 GLAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
506-604 |
1.37e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 55.47 E-value: 1.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 506 LKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFL----TTKEKGTGLGLMVTFNIIE 581
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYrgdnSRNTEGAGLGLSIAKAIIE 80
|
90 100
....*....|....*....|...
gi 16078463 582 NHQGVIHVDSHpEKGTAFKISFP 604
Cdd:cd16923 81 LHGGSASAEYD-DNHDLFKVRLP 102
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
495-604 |
1.40e-09 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 60.70 E-value: 1.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 495 DSIYINGDQNQLKQVFI----NLIKNAVESMP--DGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKEKG 568
Cdd:PRK11086 419 DSQLPDSGDEDQVHELItilgNLIENALEAVGgeEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTKGSN 498
|
90 100 110
....*....|....*....|....*....|....*.
gi 16078463 569 TGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:PRK11086 499 RGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
267-330 |
1.51e-09 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 54.33 E-value: 1.51e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16078463 267 ERYQLLIQNSIDTIAVI-HNGKWVFMNESGISLFEAaTYEDLIGKNIYDQLHPCDHEDVKERIQN 330
Cdd:smart00091 1 ERLRAILESLPDGIFVLdLDGRILYANPAAEELLGY-SPEELIGKSLLELIHPEDRERVQEALQR 64
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
501-603 |
1.70e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 56.10 E-value: 1.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 501 GDQNQLKQVFINLIKNAVESMpdGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGE--PFLTTKEKGTGLGLMVTFN 578
Cdd:cd16954 33 GERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQrgQRLDEQRPGQGLGLAIAKE 110
|
90 100
....*....|....*....|....*
gi 16078463 579 IIENHQGVIHVDSHPEKGTAFKISF 603
Cdd:cd16954 111 IVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
16-108 |
1.90e-09 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 55.33 E-value: 1.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 16 DIHAVLASNGRIIYISANSKLHLGYLQGEMIGSFLKTFLHEEDQFLVESYFYNEHHL---MPCTFRFIKKDHTIVWVEAA 92
Cdd:cd00130 3 DGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGgepVTLEVRLRRKDGSVIWVLVS 82
|
90
....*....|....*.
gi 16078463 93 VEIVTTRAERTEREII 108
Cdd:cd00130 83 LTPIRDEGGEVIGLLG 98
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
145-257 |
2.40e-09 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 55.37 E-value: 2.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 145 YERLVENLPSPLC-ISVKGKIVYVNSAMLSMLGAKSKDaIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQTW-KR 222
Cdd:TIGR00229 5 YRAIFESSPDAIIvIDLEGNILYVNPAFEEIFGYSAEE-LIGRNVLELIPEEDREEVRERIERRLEGEPEPVSEERRvRR 83
|
90 100 110
....*....|....*....|....*....|....*.
gi 16078463 223 LDGTPVHLEVKASP-TVYKNQQAELLLLIDISSRKK 257
Cdd:TIGR00229 84 KDGSEIWVEVSVSPiRTNGGELGVVGIVRDITERKE 119
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
262-414 |
4.85e-09 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 57.34 E-value: 4.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 262 LQKSRERYQLLIQNSIDTIAVI-HNGKWVFMNESGISLFEAaTYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQKTESEI 340
Cdd:COG2202 6 LEESERRLRALVESSPDAIIITdLDGRILYVNPAFERLTGY-SAEELLGKTLRDLLPPEDDDEFLELLRAALAGGGVWRG 84
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16078463 341 VKQsWFTFQNRVIYTEMVCIPttFFGEA----AVQVILRDISERKQTEELMLKSEKLSIAGQLAAGIAHEIRNPLTAI 414
Cdd:COG2202 85 ELR-NRRKDGSLFWVELSISP--VRDEDgeitGFVGIARDITERKRAEEALRESEERLRLLVENAPDGIFVLDLDGRI 159
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
143-209 |
7.20e-09 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 52.40 E-value: 7.20e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16078463 143 DDYERLVENLPSPLC-ISVKGKIVYVNSAMLSMLGaKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQK 209
Cdd:smart00091 1 ERLRAILESLPDGIFvLDLDGRILYANPAAEELLG-YSPEELIGKSLLELIHPEDRERVQEALQRLLS 67
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
158-250 |
1.22e-08 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 53.02 E-value: 1.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 158 ISVKGKIVYVNSAMLSMLGAkSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQTWKRLDGTPVHLEVKASPT 237
Cdd:cd00130 8 LDLDGRILYANPAAEQLLGY-SPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTLEVRLRRKDGSVIWVLVSLTPI 86
|
90
....*....|...
gi 16078463 238 VYKNQQAELLLLI 250
Cdd:cd00130 87 RDEGGEVIGLLGV 99
|
|
| PAS_9 |
pfam13426 |
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
161-253 |
1.96e-08 |
|
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 52.08 E-value: 1.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 161 KGKIVYVNSAMLSMLGAKSKDaIIGKSSYEFIEEEYHDIVKNRIIRMqkGMEVGMIEQTWKRLDGTPVHLEVKASPTVYK 240
Cdd:pfam13426 1 DGRIIYVNDAALRLLGYTREE-LLGKSITDLFAEPEDSERLREALRE--GKAVREFEVVLYRKDGEPFPVLVSLAPIRDD 77
|
90
....*....|....*
gi 16078463 241 NQQAELLLLI--DIS 253
Cdd:pfam13426 78 GGELVGIIAIlrDIT 92
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
498-604 |
3.55e-08 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 56.78 E-value: 3.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 498 YINGDQNQLKQVFINLIKNAVEsMPDGGTVDIIIT---EDEHSVH--VTVKDEGEGIPEKVLNRIGEPF------LTTKE 566
Cdd:PRK11107 401 NVIGDPLRLQQIITNLVGNAIK-FTESGNIDILVElraLSNTKVQleVQIRDTGIGISERQQSQLFQAFrqadasISRRH 479
|
90 100 110
....*....|....*....|....*....|....*...
gi 16078463 567 KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:PRK11107 480 GGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLP 517
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
506-604 |
4.68e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 51.28 E-value: 4.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 506 LKQVFINLIKNAVESMPDggTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFL------TTKEKGTGLGLMVTFNI 579
Cdd:cd16939 1 MARALDNLLRNALRYAHR--TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVrldpsrDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*
gi 16078463 580 IENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:cd16939 79 ALWHGGHVECDDSELGGACFRLTWP 103
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
512-604 |
9.28e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 50.52 E-value: 9.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 512 NLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEpfltTKEKGTGLGLmvtFNIIE------NHQG 585
Cdd:cd16924 12 NAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLNILGK----KPKEGNGIGL---YNVHQrlillfGEDY 84
|
90
....*....|....*....
gi 16078463 586 VIHVDSHPEKGTAFKISFP 604
Cdd:cd16924 85 GIHIASEPDKGTRITFTIP 103
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
506-587 |
5.50e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 48.21 E-value: 5.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 506 LKQVFINLIKNAVESmpDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE----KGTGLGLMVTFNIIE 581
Cdd:cd16950 1 LKRVLSNLVDNALRY--GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNargtSGTGLGLAIVQRISD 78
|
....*.
gi 16078463 582 NHQGVI 587
Cdd:cd16950 79 AHGGSL 84
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
516-574 |
2.17e-06 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 47.22 E-value: 2.17e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16078463 516 NAVE---SMPDGGTVDIIITEDEHSVHVTVKDEGEGIPekvLNRIGEPFLTTKEKGTGLGLM 574
Cdd:COG2172 45 NAVRhayGGDPDGPVEVELELDPDGLEIEVRDEGPGFD---PEDLPDPYSTLAEGGRGLFLI 103
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
502-605 |
4.72e-06 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 49.45 E-value: 4.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 502 DQNQLKQVFINLIKNAVES---MPDGG-TVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTK-----EKGTGLG 572
Cdd:PRK15053 429 DSTEFAAIVGNLLDNAFEAslrSDEGNkIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVSTRadepgEHGIGLY 508
|
90 100 110
....*....|....*....|....*....|...
gi 16078463 573 LMVTFniIENHQGVIHVDSHPEKGTAFKISFPK 605
Cdd:PRK15053 509 LIASY--VTRCGGVITLEDNDPCGTLFSIFIPK 539
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
368-604 |
5.84e-06 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 48.08 E-value: 5.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 368 AAVQVILRDISERKQTEELMLKSEKLSIAGQLA--AGIAHEIR----NPLTAIKGFLQLMKPTMEGNEhyfDIVFSELSR 441
Cdd:COG4585 20 LLLALVLLRARRAERAAELERELAARAEEAREEerRRIARELHdgvgQSLSAIKLQLEAARRLLDADP---EAAREELEE 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 442 IELILSE-------LLMLAKPQQnavkeyLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQlkQVF-I-- 511
Cdd:COG4585 97 IRELAREalaelrrLVRGLRPPA------LDDLGLAAALEELAERLLRAAGIRVELDVDGDPDRLPPEVEL--ALYrIvq 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 512 ----NLIKNAvesmpDGGTVDIIITEDEHSVHVTVKDEGEGIPekvlnrigepflTTKEKGTGLGLMvtfNI---IENHQ 584
Cdd:COG4585 169 ealtNALKHA-----GATRVTVTLEVDDGELTLTVRDDGVGFD------------PEAAPGGGLGLR---GMrerAEALG 228
|
250 260
....*....|....*....|
gi 16078463 585 GVIHVDSHPEKGTAFKISFP 604
Cdd:COG4585 229 GTLTIGSAPGGGTRVRATLP 248
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
143-280 |
1.94e-05 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 47.46 E-value: 1.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 143 DDYERLVENLPSPLCIS-VKGKIVYVNSAMLSMLGAKSKDaIIGKSSYEFIEEEYHDIVknriirMQKGMEVGMIEQtwk 221
Cdd:COG3829 11 EELEAILDSLDDGIIVVdADGRITYVNRAAERILGLPREE-VIGKNVTELIPNSPLLEV------LKTGKPVTGVIQ--- 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16078463 222 RLDGTPVHLEVKASPtVYKNQQAELLLLI--DISSRKKFQTILQKSRERYQLLIQNSIDTI 280
Cdd:COG3829 81 KTGGKGKTVIVTAIP-IFEDGEVIGAVETfrDITELKRLERKLREEELERGLSAKYTFDDI 140
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
501-603 |
3.47e-05 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 46.55 E-value: 3.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 501 GDQNQLKQVFINLIKNA----VEsmpdggTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIgepF-----LTTKEKGTGL 571
Cdd:PRK10815 374 GEKNDFMEVMGNVLDNAckycLE------FVEISARQTDEHLHIVVEDDGPGIPESKRELI---FdrgqrADTLRPGQGL 444
|
90 100 110
....*....|....*....|....*....|..
gi 16078463 572 GLMVTFNIIENHQGVIHVDSHPEKGTAFKISF 603
Cdd:PRK10815 445 GLSVAREITEQYEGKISAGDSPLGGARMEVIF 476
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
11-71 |
3.50e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 42.00 E-value: 3.50e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16078463 11 LQTKTDIHAVLASNGRIIYISANSKLHLGYLQGEMIGSFLKTFLHEEDQFLVESYFYNEHH 71
Cdd:smart00091 7 LESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRLLS 67
|
|
| PAS_3 |
pfam08447 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
27-91 |
4.72e-05 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.
Pssm-ID: 430001 [Multi-domain] Cd Length: 89 Bit Score: 42.33 E-value: 4.72e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 27 IIYISANSKLHLGYLQGEMIGSF--LKTFLHEEDQFLVESYFY---NEHHLMPCTFRFIKKDHTIVWVEA 91
Cdd:pfam08447 1 IIYWSPRFEEILGYTPEELLGKGesWLDLVHPDDRERVREALWealKGGEPYSGEYRIRRKDGEYRWVEA 70
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
280-330 |
5.02e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 42.62 E-value: 5.02e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 16078463 280 IAVIHNGKWVFMNESGISLFeAATYEDLIGKNIYDQLHPCDHEDVKERIQN 330
Cdd:cd00130 6 IVLDLDGRILYANPAAEQLL-GYSPEELIGKSLLDLIHPEDREELRERLEN 55
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
146-274 |
2.00e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 44.66 E-value: 2.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 146 ERLVENLPSP-LCISVKGKIVYVNSAMLSMLGAkSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQTWKRLD 224
Cdd:PRK13560 207 QQLLDNIADPaFWKDEDAKVFGCNDAACLACGF-RREEIIGMSIHDFAPAQPADDYQEADAAKFDADGSQIIEAEFQNKD 285
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 16078463 225 GTPVHLEVKASPTVY---KNQQAELLLLI-DISSRKKFQTILQKSRERYQLLIQ 274
Cdd:PRK13560 286 GRTRPVDVIFNHAEFddkENHCAGLVGAItDISGRRAAERELLEKEDMLRAIIE 339
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
145-206 |
3.14e-04 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 39.07 E-value: 3.14e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16078463 145 YERLVENLPSPLCISVKG-KIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIR 206
Cdd:pfam13188 3 LRALFESSPDGILVLDEGgRIIYVNPAALELLGYELLGELLGELLDLLDPLLEDALELLRELR 65
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
525-604 |
4.20e-04 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 41.41 E-value: 4.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 525 GTVDIIITEDEHSVHVTVKDEGEGI-PEKVLNR-----------------------IGEPFLTTKEK-----GTGLGLMV 575
Cdd:cd16916 70 GTITLRAEHQGNQVVIEVSDDGRGIdREKIREKaierglitadeaatlsddevlnlIFAPGFSTAEQvtdvsGRGVGMDV 149
|
90 100
....*....|....*....|....*....
gi 16078463 576 TFNIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:cd16916 150 VKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| PAS_11 |
pfam14598 |
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ... |
18-91 |
5.26e-04 |
|
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).
Pssm-ID: 464214 [Multi-domain] Cd Length: 110 Bit Score: 39.97 E-value: 5.26e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16078463 18 HAVLASNGRIIYISANSKLHLGYLQGEMIGSFLKTFLHEED-----QFLVESYFYNEHHLMPCtFRFIKKDHTIVWVEA 91
Cdd:pfam14598 5 TTRHDIDGKIISCDTRAPFSLGYEKDELVGRSIYDLVHPQDlrtakSHLREIIQTRGRATSPS-YRLRLRDGDFLSVHT 82
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
512-604 |
9.72e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 38.30 E-value: 9.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 512 NLIKNAvesmpDGGTVDIIITEDEHSVHVTVKDEGEGIPEKvlnrigepfltTKEKGTGLGLMvtfniieNHQ------- 584
Cdd:cd16917 11 NALKHA-----GASRVRVTLSYTADELTLTVVDDGVGFDGP-----------APPGGGGFGLL-------GMReraellg 67
|
90 100
....*....|....*....|
gi 16078463 585 GVIHVDSHPEKGTAFKISFP 604
Cdd:cd16917 68 GTLTIGSRPGGGTRVTARLP 87
|
|
| HATPase_SpoIIAB-like |
cd16942 |
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ... |
526-597 |
1.68e-03 |
|
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.
Pssm-ID: 340418 [Multi-domain] Cd Length: 135 Bit Score: 39.06 E-value: 1.68e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16078463 526 TVDIIITEDEhsVHVTVKDEGEGIPEkvLNRIGEPFLTTKE--KGTGLGlmvtFNIIENHQGVIHVDSHPEKGT 597
Cdd:cd16942 64 SISVIIEDGV--VHLTVRDEGVGIPD--IEEARQPLFTTKPelERSGMG----FTIMENFMDEVIVESEVNKGT 129
|
|
| PAS_9 |
pfam13426 |
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
285-379 |
3.86e-03 |
|
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 37.06 E-value: 3.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 285 NGKWVFMNESGISLFeAATYEDLIGKNIYDQLHPCDHEdvkERIQNIAEQKTESEIVKQSWFTFQNRVIYTEMVCIPTTF 364
Cdd:pfam13426 1 DGRIIYVNDAALRLL-GYTREELLGKSITDLFAEPEDS---ERLREALREGKAVREFEVVLYRKDGEPFPVLVSLAPIRD 76
|
90
....*....|....*..
gi 16078463 365 FGEA--AVQVILRDISE 379
Cdd:pfam13426 77 DGGElvGIIAILRDITE 93
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
20-109 |
3.96e-03 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 37.40 E-value: 3.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 20 VLASNGRIIYISANSKLHLGYLQGEMIG-SFLKTFLHEEDQFLVESYFYNEHHLMPCT---FRFIKKDHTIVWVEaaVEI 95
Cdd:pfam00989 16 VVDEDGRILYVNAAAEELLGLSREEVIGkSLLDLIPEEDDAEVAELLRQALLQGEESRgfeVSFRVPDGRPRHVE--VRA 93
|
90
....*....|....
gi 16078463 96 VTTRAERTEREIIL 109
Cdd:pfam00989 94 SPVRDAGGEILGFL 107
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
513-604 |
5.39e-03 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 39.78 E-value: 5.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 513 LIKNAV----EsMPD-----G----GTVDIIITEDEHSVHVTVKDEGEGI-PEKVLNR---------------------- 556
Cdd:COG0643 285 LVRNAVdhgiE-TPEerlaaGkpetGTITLSAYHEGGRVVIEVSDDGRGLdLEKIRAKaiekglitaeeaaalsdeelle 363
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 16078463 557 -IGEPFLTTKEK-----GTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFP 604
Cdd:COG0643 364 lIFAPGFSTAEEvtdlsGRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLP 417
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
149-236 |
9.30e-03 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 36.24 E-value: 9.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078463 149 VENLPSPLC-ISVKGKIVYVNSAMLSMLGAKSkDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVgMIEQTWKRLDGTP 227
Cdd:pfam08448 1 LDSLPDALAvLDPDGRVRYANAAAAELFGLPP-EELLGKTLAELLPPEDAARLERALRRALEGEEP-IDFLEELLLNGEE 78
|
....*....
gi 16078463 228 VHLEVKASP 236
Cdd:pfam08448 79 RHYELRLTP 87
|
|
| |
